                         SEQUENCE LISTING

<110>  Scribe Therapeutics Inc.
 
<120>  PARTICLE DELIVERY SYSTEMS

<130>  SCRB-024/05WO 333322-2107

<150>  US 63/120,864
<151>  2020-12-03

<150>  US 63/035,576
<151>  2020-06-05

<150>  US 62/983,460
<151>  2002-02-28

<150>  US 62/968,915
<151>  2020-01-31

<150>  US 62/944,982
<151>  2019-12-06

<160>  1010  

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Unknown

<220>  
<223>  Deltaproteobacteria sp.

<400>  1

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr 
            820                 825                 830         


Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly 
        835                 840                 845             


Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser 
865                 870                 875                 880 


Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser 
                885                 890                 895     


Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys 
        915                 920                 925             


Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  2
<211>  978
<212>  PRT
<213>  Unknown

<220>  
<223>  Planctomycetes sp.

<400>  2

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3
<211>  855
<212>  PRT
<213>  Unknown

<220>  
<223>  Candidatus sungbacteria sp.

<400>  3

Met Asp Asn Ala Asn Lys Pro Ser Thr Lys Ser Leu Val Asn Thr Thr 
1               5                   10                  15      


Arg Ile Ser Asp His Phe Gly Val Thr Pro Gly Gln Val Thr Arg Val 
            20                  25                  30          


Phe Ser Phe Gly Ile Ile Pro Thr Lys Arg Gln Tyr Ala Ile Ile Glu 
        35                  40                  45              


Arg Trp Phe Ala Ala Val Glu Ala Ala Arg Glu Arg Leu Tyr Gly Met 
    50                  55                  60                  


Leu Tyr Ala His Phe Gln Glu Asn Pro Pro Ala Tyr Leu Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Tyr Glu Thr Phe Phe Lys Gly Arg Pro Val Leu Asn Gly Leu 
                85                  90                  95      


Arg Asp Ile Asp Pro Thr Ile Met Thr Ser Ala Val Phe Thr Ala Leu 
            100                 105                 110         


Arg His Lys Ala Glu Gly Ala Met Ala Ala Phe His Thr Asn His Arg 
        115                 120                 125             


Arg Leu Phe Glu Glu Ala Arg Lys Lys Met Arg Glu Tyr Ala Glu Cys 
    130                 135                 140                 


Leu Lys Ala Asn Glu Ala Leu Leu Arg Gly Ala Ala Asp Ile Asp Trp 
145                 150                 155                 160 


Asp Lys Ile Val Asn Ala Leu Arg Thr Arg Leu Asn Thr Cys Leu Ala 
                165                 170                 175     


Pro Glu Tyr Asp Ala Val Ile Ala Asp Phe Gly Ala Leu Cys Ala Phe 
            180                 185                 190         


Arg Ala Leu Ile Ala Glu Thr Asn Ala Leu Lys Gly Ala Tyr Asn His 
        195                 200                 205             


Ala Leu Asn Gln Met Leu Pro Ala Leu Val Lys Val Asp Glu Pro Glu 
    210                 215                 220                 


Glu Ala Glu Glu Ser Pro Arg Leu Arg Phe Phe Asn Gly Arg Ile Asn 
225                 230                 235                 240 


Asp Leu Pro Lys Phe Pro Val Ala Glu Arg Glu Thr Pro Pro Asp Thr 
                245                 250                 255     


Glu Thr Ile Ile Arg Gln Leu Glu Asp Met Ala Arg Val Ile Pro Asp 
            260                 265                 270         


Thr Ala Glu Ile Leu Gly Tyr Ile His Arg Ile Arg His Lys Ala Ala 
        275                 280                 285             


Arg Arg Lys Pro Gly Ser Ala Val Pro Leu Pro Gln Arg Val Ala Leu 
    290                 295                 300                 


Tyr Cys Ala Ile Arg Met Glu Arg Asn Pro Glu Glu Asp Pro Ser Thr 
305                 310                 315                 320 


Val Ala Gly His Phe Leu Gly Glu Ile Asp Arg Val Cys Glu Lys Arg 
                325                 330                 335     


Arg Gln Gly Leu Val Arg Thr Pro Phe Asp Ser Gln Ile Arg Ala Arg 
            340                 345                 350         


Tyr Met Asp Ile Ile Ser Phe Arg Ala Thr Leu Ala His Pro Asp Arg 
        355                 360                 365             


Trp Thr Glu Ile Gln Phe Leu Arg Ser Asn Ala Ala Ser Arg Arg Val 
    370                 375                 380                 


Arg Ala Glu Thr Ile Ser Ala Pro Phe Glu Gly Phe Ser Trp Thr Ser 
385                 390                 395                 400 


Asn Arg Thr Asn Pro Ala Pro Gln Tyr Gly Met Ala Leu Ala Lys Asp 
                405                 410                 415     


Ala Asn Ala Pro Ala Asp Ala Pro Glu Leu Cys Ile Cys Leu Ser Pro 
            420                 425                 430         


Ser Ser Ala Ala Phe Ser Val Arg Glu Lys Gly Gly Asp Leu Ile Tyr 
        435                 440                 445             


Met Arg Pro Thr Gly Gly Arg Arg Gly Lys Asp Asn Pro Gly Lys Glu 
    450                 455                 460                 


Ile Thr Trp Val Pro Gly Ser Phe Asp Glu Tyr Pro Ala Ser Gly Val 
465                 470                 475                 480 


Ala Leu Lys Leu Arg Leu Tyr Phe Gly Arg Ser Gln Ala Arg Arg Met 
                485                 490                 495     


Leu Thr Asn Lys Thr Trp Gly Leu Leu Ser Asp Asn Pro Arg Val Phe 
            500                 505                 510         


Ala Ala Asn Ala Glu Leu Val Gly Lys Lys Arg Asn Pro Gln Asp Arg 
        515                 520                 525             


Trp Lys Leu Phe Phe His Met Val Ile Ser Gly Pro Pro Pro Val Glu 
    530                 535                 540                 


Tyr Leu Asp Phe Ser Ser Asp Val Arg Ser Arg Ala Arg Thr Val Ile 
545                 550                 555                 560 


Gly Ile Asn Arg Gly Glu Val Asn Pro Leu Ala Tyr Ala Val Val Ser 
                565                 570                 575     


Val Glu Asp Gly Gln Val Leu Glu Glu Gly Leu Leu Gly Lys Lys Glu 
            580                 585                 590         


Tyr Ile Asp Gln Leu Ile Glu Thr Arg Arg Arg Ile Ser Glu Tyr Gln 
        595                 600                 605             


Ser Arg Glu Gln Thr Pro Pro Arg Asp Leu Arg Gln Arg Val Arg His 
    610                 615                 620                 


Leu Gln Asp Thr Val Leu Gly Ser Ala Arg Ala Lys Ile His Ser Leu 
625                 630                 635                 640 


Ile Ala Phe Trp Lys Gly Ile Leu Ala Ile Glu Arg Leu Asp Asp Gln 
                645                 650                 655     


Phe His Gly Arg Glu Gln Lys Ile Ile Pro Lys Lys Thr Tyr Leu Ala 
            660                 665                 670         


Asn Lys Thr Gly Phe Met Asn Ala Leu Ser Phe Ser Gly Ala Val Arg 
        675                 680                 685             


Val Asp Lys Lys Gly Asn Pro Trp Gly Gly Met Ile Glu Ile Tyr Pro 
    690                 695                 700                 


Gly Gly Ile Ser Arg Thr Cys Thr Gln Cys Gly Thr Val Trp Leu Ala 
705                 710                 715                 720 


Arg Arg Pro Lys Asn Pro Gly His Arg Asp Ala Met Val Val Ile Pro 
                725                 730                 735     


Asp Ile Val Asp Asp Ala Ala Ala Thr Gly Phe Asp Asn Val Asp Cys 
            740                 745                 750         


Asp Ala Gly Thr Val Asp Tyr Gly Glu Leu Phe Thr Leu Ser Arg Glu 
        755                 760                 765             


Trp Val Arg Leu Thr Pro Arg Tyr Ser Arg Val Met Arg Gly Thr Leu 
    770                 775                 780                 


Gly Asp Leu Glu Arg Ala Ile Arg Gln Gly Asp Asp Arg Lys Ser Arg 
785                 790                 795                 800 


Gln Met Leu Glu Leu Ala Leu Glu Pro Gln Pro Gln Trp Gly Gln Phe 
                805                 810                 815     


Phe Cys His Arg Cys Gly Phe Asn Gly Gln Ser Asp Val Leu Ala Ala 
            820                 825                 830         


Thr Asn Leu Ala Arg Arg Ala Ile Ser Leu Ile Arg Arg Leu Pro Asp 
        835                 840                 845             


Thr Asp Thr Pro Pro Thr Pro 
    850                 855 


<210>  4
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  4
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag agaaaccgau aaguaaaacg caucaaag                   108


<210>  5
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  5
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  6
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  6
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag a                                                 81


<210>  7
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  7
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucgg                                                     78


<210>  8
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  8
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga                                                   80


<210>  9
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  9
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgg                                                      77


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  10
guuuacacac ucccucucau agggu                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  11
guuuacacac ucccucucau gaggu                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  12
uuuuacauac ccccucucau gggau                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  13
guuuacacac ucccucucau ggggg                                             25


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  14
ccagcgacua ugucguaugg                                                   20


<210>  15
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  15
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  16
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  16
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cgga                                                         74


<210>  17
<211>  7
<212>  PRT
<213>  Unknown

<220>  
<223>  TEV protease cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gly or Ser

<400>  17

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Unknown

<220>  
<223>  TEV protease cleavage site

<400>  18

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Unknown

<220>  
<223>  TEV protease cleavage site

<400>  19

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  Unknown

<220>  
<223>  HIV-1 cleavage site

<400>  20

Ser Gln Asn Tyr Pro Ile Val Gln 
1               5               


<210>  21
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  21

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  22
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  22

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Thr Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser 
            820                 825                 830         


Asp Gly Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu 
    850                 855                 860                 


Leu Ser Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu 
            900                 905                 910         


Asp Cys Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  23
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  23

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys 
        195                 200                 205             


Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn 
                245                 250                 255     


Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu 
            260                 265                 270         


Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro 
305                 310                 315                 320 


Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg Arg 
                325                 330                 335     


Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys Leu 
            340                 345                 350         


Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val Thr 
        355                 360                 365             


Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro Asn 
    370                 375                 380                 


Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys Lys 
385                 390                 395                 400 


Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys Lys 
                405                 410                 415     


Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg Ile 
            420                 425                 430         


Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu Ala 
        435                 440                 445             


Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp Leu 
    450                 455                 460                 


Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp Glu 
465                 470                 475                 480 


Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly Asp 
                485                 490                 495     


Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val Asp 
            500                 505                 510         


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
        515                 520                 525             


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
    530                 535                 540                 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
545                 550                 555                 560 


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
                565                 570                 575     


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
            580                 585                 590         


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
        595                 600                 605             


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
    610                 615                 620                 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
625                 630                 635                 640 


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
                645                 650                 655     


Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp Arg 
            660                 665                 670         


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
        675                 680                 685             


Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile Leu 
    690                 695                 700                 


Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala Ala 
705                 710                 715                 720 


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe Ala 
                725                 730                 735     


Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala Arg 
            740                 745                 750         


Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe Glu 
        755                 760                 765             


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Thr 
    770                 775                 780                 


Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
785                 790                 795                 800 


Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln 
                805                 810                 815     


Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr Ala 
            820                 825                 830         


Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly Trp 
        835                 840                 845             


Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile Thr 
    850                 855                 860                 


Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser Ala 
865                 870                 875                 880 


Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser Lys 
                885                 890                 895     


Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys Arg 
            900                 905                 910         


Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys Gly 
        915                 920                 925             


His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser 
    930                 935                 940                 


Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys Ser 
945                 950                 955                 960 


Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg Arg 
                965                 970                 975     


Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985 


<210>  24
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  24

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
            820                 825                 830         


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
        835                 840                 845             


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
865                 870                 875                 880 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
                885                 890                 895     


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
        915                 920                 925             


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  25
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  25

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala 
        915                 920     


<210>  26
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  26

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala 
        915                 920 


<210>  27
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  27

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Asn Ala Ala 
    50                  55                  60                  


Asn Asn Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala 
65                  70                  75                  80  


Ile Leu Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu 
                85                  90                  95      


Met Cys Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  28
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  28

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  29
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  29

Met Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp 
1               5                   10                  15      


Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe 
            20                  25                  30          


Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro Ala Pro 
        35                  40                  45              


Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly Asn Glu 
    50                  55                  60                  


Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu 
65                  70                  75                  80  


Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro His Thr 
                85                  90                  95      


Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu Ile Leu 
            100                 105                 110         


Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser 
        115                 120                 125             


Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile His Val 
    130                 135                 140                 


Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile Gly Gly 
145                 150                 155                 160 


Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp Ala Cys 
                165                 170                 175     


Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu 
            180                 185                 190         


Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu 
        195                 200                 205             


Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu 
    210                 215                 220                 


Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val 
225                 230                 235                 240 


Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln Lys Leu 
                245                 250                 255     


Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe 
            260                 265                 270         


Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp 
        275                 280                 285             


Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp 
    290                 295                 300                 


Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala 
305                 310                 315                 320 


Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys 
                325                 330                 335     


Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu Lys Lys 
            340                 345                 350         


His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile 
        355                 360                 365             


Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu 
    370                 375                 380                 


Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu 
385                 390                 395                 400 


Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys 
                405                 410                 415     


Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp 
            420                 425                 430         


Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Arg Val Val Asp 
        435                 440                 445             


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
    450                 455                 460                 


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
465                 470                 475                 480 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
                485                 490                 495     


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
            500                 505                 510         


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
        515                 520                 525             


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
    530                 535                 540                 


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
545                 550                 555                 560 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
                565                 570                 575     


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
            580                 585                 590         


Val Asp Pro Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg 
        595                 600                 605             


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
    610                 615                 620                 


Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu 
625                 630                 635                 640 


Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys 
                645                 650                 655     


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala 
            660                 665                 670         


Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg 
        675                 680                 685             


Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu 
    690                 695                 700                 


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala 
705                 710                 715                 720 


Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
                725                 730                 735     


Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr 
            740                 745                 750         


Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp 
        755                 760                 765             


Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met 
    770                 775                 780                 


Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr 
785                 790                 795                 800 


Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu 
                805                 810                 815     


Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp 
            820                 825                 830         


Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe 
        835                 840                 845             


Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe 
    850                 855                 860                 


Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp 
865                 870                 875                 880 


Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr 
                885                 890                 895     


Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe 
            900                 905                 910         


Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
        915                 920                 925 


<210>  30
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  30

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Thr Ser Arg Ala Asn 
    50                  55                  60                  


Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu 
65                  70                  75                  80  


His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser 
                85                  90                  95      


Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys 
        195                 200                 205             


Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn 
                245                 250                 255     


Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu 
            260                 265                 270         


Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln 
                325                 330                 335     


Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
785                 790                 795                 800 


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
                805                 810                 815     


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
            820                 825                 830         


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
        835                 840                 845             


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
    850                 855                 860                 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
865                 870                 875                 880 


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
                885                 890                 895     


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
            900                 905                 910         


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
        915                 920                 925             


Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn 
    930                 935                 940                 


Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln 
945                 950                 955                 960 


Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975 


<210>  31
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  31

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Arg Val Val Asp Ile Ser Gly Phe Ser Ile Gly 
            500                 505                 510         


Ser Asp Gly His Ser Ile Gln Tyr Arg Asn Leu Leu Ala Trp Lys Tyr 
        515                 520                 525             


Leu Glu Asn Gly Lys Arg Glu Phe Tyr Leu Leu Met Asn Tyr Gly Lys 
    530                 535                 540                 


Lys Gly Arg Ile Arg Phe Thr Asp Gly Thr Asp Ile Lys Lys Ser Gly 
545                 550                 555                 560 


Lys Trp Gln Gly Leu Leu Tyr Gly Gly Gly Lys Ala Lys Val Ile Asp 
                565                 570                 575     


Leu Thr Phe Asp Pro Asp Asp Glu Gln Leu Ile Ile Leu Pro Leu Ala 
            580                 585                 590         


Phe Gly Thr Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Gly Leu Ile Lys Leu Ala Asn Gly Arg Val Ile Glu Lys 
    610                 615                 620                 


Thr Ile Tyr Asn Lys Lys Ile Gly Arg Asp Glu Pro Ala Leu Phe Val 
625                 630                 635                 640 


Ala Leu Thr Phe Glu Arg Arg Glu Val Val Asp Pro Ser Asn Ile Lys 
                645                 650                 655     


Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val 
            660                 665                 670         


Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp 
        675                 680                 685             


Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys 
    690                 695                 700                 


Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg 
705                 710                 715                 720 


Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala 
                725                 730                 735     


Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val 
            740                 745                 750         


Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly 
        755                 760                 765             


Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met 
    770                 775                 780                 


Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr 
785                 790                 795                 800 


Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn 
                805                 810                 815     


Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys 
            820                 825                 830         


Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu 
        835                 840                 845             


Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln 
    850                 855                 860                 


Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu 
865                 870                 875                 880 


Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu 
                885                 890                 895     


Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu 
            900                 905                 910         


Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln 
        915                 920                 925             


Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu 
    930                 935                 940                 


Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg 
945                 950                 955                 960 


Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu 
                965                 970                 975     


Val Trp Lys Pro Ala Val 
            980         


<210>  32
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  32

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  33
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  33

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala 
    


<210>  34
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  34

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  35
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  35

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Gln Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  36
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  36

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Gln Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  37
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  37

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Ile Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  38
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  38

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  39
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  39

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  40
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  40

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  41
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  41

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  42
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  42

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Lys Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  43
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  43

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  44
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  44

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  45
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  45

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  46
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  46

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  47
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  47

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  48
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  48

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Asp Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  49
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  49

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Phe Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  50
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  50

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  51
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  51

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  52
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  52

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  53
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  53

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  54
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  54

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Lys Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  55
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  55

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  56
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  56

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Met Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  57
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  57

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  58
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  58

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  59
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  59

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  60
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  60

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  61
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  61

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Val 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  62
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  62

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  63
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  63

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  64
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  64

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  65
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  65

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  66
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  66

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  67
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  67

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  68
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  68

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  69
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  69

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  70
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  70

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  71
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  71

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  72
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  72

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  73
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  73

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  74
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  74

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  75
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  75

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  76
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  76

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  77
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  77

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  78
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  78

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  79
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  79

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  80
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  80

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  81
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  81

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  82
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  82

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  83
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  83

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  84
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  84

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  85
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  85

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  86
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  86

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  87
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  87

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  88
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  88

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  89
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  89

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  90
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  90

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  91
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  91

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  92
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  92

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  93
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  93

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  94
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  94

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  95
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  95

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  96
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  96

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  97
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  97

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  98
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  98

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  99
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  99

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  100
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  100

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  101
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  101

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  102
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  102

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  103
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  103

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  104
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  104

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  105
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  105

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  106
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  106

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  107
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  107

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  108
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  108

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  109
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  109

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  110
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  110

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  111
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  111

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  112
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  112

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Gly Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  113
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  113

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  114
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  114

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  115
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  115

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         


<210>  116
<211>  84
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  116

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Cys Met Gln Val Trp Pro Pro Ile 
    50                  55                  60                  


Gly Lys Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Pro Leu Thr Arg 
65                  70                  75                  80  


Asp Ser Arg Ala 
                


<210>  117
<211>  57
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  117

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Ser 
    50                  55          


<210>  118
<211>  85
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  118

Met Ala Ser Ser Met Leu Ser Ser Ala Thr Met Val Ala Ser Pro Ala 
1               5                   10                  15      


Gln Ala Thr Met Val Ala Pro Phe Asn Gly Leu Lys Ser Ser Ala Ala 
            20                  25                  30          


Phe Pro Ala Thr Arg Lys Ala Asn Asn Asp Ile Thr Ser Ile Thr Ser 
        35                  40                  45              


Asn Gly Gly Arg Val Asn Cys Met Gln Val Trp Pro Pro Ile Glu Lys 
    50                  55                  60                  


Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Asp Leu Thr Asp Ser Gly 
65                  70                  75                  80  


Gly Arg Val Asn Cys 
                85  


<210>  119
<211>  76
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  119

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Gln Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  120
<211>  76
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  120

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Trp Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  121
<211>  72
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  121

Met Ala Gln Ile Asn Asn Met Ala Gln Gly Ile Gln Thr Leu Asn Pro 
1               5                   10                  15      


Asn Ser Asn Phe His Lys Pro Gln Val Pro Lys Ser Ser Ser Phe Leu 
            20                  25                  30          


Val Phe Gly Ser Lys Lys Leu Lys Asn Ser Ala Asn Ser Met Leu Val 
        35                  40                  45              


Leu Lys Lys Asp Ser Ile Phe Met Gln Leu Phe Cys Ser Phe Arg Ile 
    50                  55                  60                  


Ser Ala Ser Val Ala Thr Ala Cys 
65                  70          


<210>  122
<211>  69
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  122

Met Ala Ala Leu Val Thr Ser Gln Leu Ala Thr Ser Gly Thr Val Leu 
1               5                   10                  15      


Ser Val Thr Asp Arg Phe Arg Arg Pro Gly Phe Gln Gly Leu Arg Pro 
            20                  25                  30          


Arg Asn Pro Ala Asp Ala Ala Leu Gly Met Arg Thr Val Gly Ala Ser 
        35                  40                  45              


Ala Ala Pro Lys Gln Ser Arg Lys Pro His Arg Phe Asp Arg Arg Cys 
    50                  55                  60                  


Leu Ser Met Val Val 
65                  


<210>  123
<211>  77
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  123

Met Ala Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe 
1               5                   10                  15      


Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe 
            20                  25                  30          


Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu 
        35                  40                  45              


Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val 
    50                  55                  60                  


Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Cys 
65                  70                  75          


<210>  124
<211>  57
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  124

Met Ala Ser Ser Val Leu Ser Ser Ala Ala Val Ala Thr Arg Ser Asn 
1               5                   10                  15      


Val Ala Gln Ala Asn Met Val Ala Pro Phe Thr Gly Leu Lys Ser Ala 
            20                  25                  30          


Ala Ser Phe Pro Val Ser Arg Lys Gln Asn Leu Asp Ile Thr Ser Ile 
        35                  40                  45              


Ala Ser Asn Gly Gly Arg Val Gln Cys 
    50                  55          


<210>  125
<211>  65
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  125

Met Glu Ser Leu Ala Ala Thr Ser Val Phe Ala Pro Ser Arg Val Ala 
1               5                   10                  15      


Val Pro Ala Ala Arg Ala Leu Val Arg Ala Gly Thr Val Val Pro Thr 
            20                  25                  30          


Arg Arg Thr Ser Ser Thr Ser Gly Thr Ser Gly Val Lys Cys Ser Ala 
        35                  40                  45              


Ala Val Thr Pro Gln Ala Ser Pro Val Ile Ser Arg Ser Ala Ala Ala 
    50                  55                  60                  


Ala 
65  


<210>  126
<211>  72
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  126

Met Gly Ala Ala Ala Thr Ser Met Gln Ser Leu Lys Phe Ser Asn Arg 
1               5                   10                  15      


Leu Val Pro Pro Ser Arg Arg Leu Ser Pro Val Pro Asn Asn Val Thr 
            20                  25                  30          


Cys Asn Asn Leu Pro Lys Ser Ala Ala Pro Val Arg Thr Val Lys Cys 
        35                  40                  45              


Cys Ala Ser Ser Trp Asn Ser Thr Ile Asn Gly Ala Ala Ala Thr Thr 
    50                  55                  60                  


Asn Gly Ala Ser Ala Ala Ser Ser 
65                  70          


<210>  127
<211>  20
<212>  PRT
<213>  Unknown

<220>  
<223>  endosomal escape polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, His or Arg

<400>  127

Gly Leu Phe Xaa Ala Leu Leu Xaa Leu Leu Xaa Ser Leu Trp Xaa Leu 
1               5                   10                  15      


Leu Leu Xaa Ala 
            20  


<210>  128
<211>  20
<212>  PRT
<213>  Unknown

<220>  
<223>  endosomal escape polypeptide

<400>  128

Gly Leu Phe His Ala Leu Leu His Leu Leu His Ser Leu Trp His Leu 
1               5                   10                  15      


Leu Leu His Ala 
            20  


<210>  129
<211>  9
<212>  PRT
<213>  Unknown

<220>  
<223>  endosomal escape polypeptide

<400>  129

His His His His His His His His His 
1               5                   


<210>  130
<211>  7
<212>  PRT
<213>  Betapolyomavirus macaca mulatta polyomavirus 1

<400>  130

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  131
<211>  16
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  131

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  132
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  132

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  133
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  133

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  134
<211>  38
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  134

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  135
<211>  42
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  135

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  136
<211>  8
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  136

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  137

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  138

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  139
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  139

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  140
<211>  5
<212>  PRT
<213>  Alphainfluenzavirus influenza A virus

<400>  140

Asp Arg Leu Arg Arg 
1               5   


<210>  141
<211>  7
<212>  PRT
<213>  Alphainfluenzavirus influenza A virus

<400>  141

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  142
<211>  10
<212>  PRT
<213>  Deltavirus hepatitis delta virus

<400>  142

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  143
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  143

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  144
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  144

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  145
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  145

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  146
<211>  8
<212>  PRT
<213>  Orthobornavirus mammalian 1 orthobornavirus

<400>  146

Pro Arg Pro Arg Lys Ile Pro Arg 
1               5               


<210>  147
<211>  9
<212>  PRT
<213>  Hepacivirus hepacivirus C

<400>  147

Pro Pro Arg Lys Lys Arg Thr Val Val 
1               5                   


<210>  148
<211>  12
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  148

Asn Leu Ser Lys Lys Lys Lys Arg Lys Arg Glu Lys 
1               5                   10          


<210>  149
<211>  10
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  149

Arg Arg Pro Ser Arg Pro Phe Arg Lys Pro 
1               5                   10  


<210>  150
<211>  8
<212>  PRT
<213>  Lymphocryptovirus human gammaherpesvirus 4

<400>  150

Lys Arg Pro Arg Ser Pro Ser Ser 
1               5               


<210>  151
<211>  19
<212>  PRT
<213>  Alphainfluenzavirus influenza A virus

<400>  151

Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly Glu Asn Glu Arg 
1               5                   10                  15      


Lys Thr Arg 
            


<210>  152
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  152

Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn 
1               5                   10      


<210>  153
<211>  8
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  153

Lys Arg Ser Phe Ser Lys Ala Phe 
1               5               


<210>  154
<211>  9
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  154

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  155
<211>  19
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  155

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys Arg Val 
1               5                   10                  15      


Lys Leu Asp 
            


<210>  156
<211>  17
<212>  PRT
<213>  Deltaretrovirus human T-lymphotropic virus 1

<400>  156

Pro Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro 
1               5                   10                  15      


Thr 
    


<210>  157
<211>  25
<212>  PRT
<213>  Caenorhabditis elegans

<400>  157

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  158
<211>  16
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  158

Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro Thr 
1               5                   10                  15      


<210>  159
<211>  13
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  159

Arg Arg Lys Lys Arg Arg Pro Arg Arg Lys Lys Arg Arg 
1               5                   10              


<210>  160
<211>  14
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  160

Pro Lys Lys Lys Ser Arg Lys Pro Lys Lys Lys Ser Arg Lys 
1               5                   10                  


<210>  161
<211>  17
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  161

His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210>  162
<211>  18
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  162

Gln Arg Pro Gly Pro Tyr Asp Arg Pro Gln Arg Pro Gly Pro Tyr Asp 
1               5                   10                  15      


Arg Pro 
        


<210>  163
<211>  16
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  163

Leu Ser Pro Ser Leu Ser Pro Leu Leu Ser Pro Ser Leu Ser Pro Leu 
1               5                   10                  15      


<210>  164
<211>  18
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  164

Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210>  165
<211>  14
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  165

Pro Lys Arg Gly Arg Gly Arg Pro Lys Arg Gly Arg Gly Arg 
1               5                   10                  


<210>  166
<211>  17
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  166

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val 
    


<210>  167
<211>  11
<212>  PRT
<213>  Lentivirus Human immunodeficiency virus 1

<400>  167

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  168
<211>  8
<212>  PRT
<213>  Lentivirus Human immunodeficiency virus 1

<400>  168

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  169
<211>  11
<212>  PRT
<213>  Lentivirus Human immunodeficiency virus 1

<400>  169

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  170
<211>  11
<212>  PRT
<213>  Lentivirus Human immunodeficiency virus 1

<400>  170

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  171
<211>  11
<212>  PRT
<213>  Lentivirus Human immunodeficiency virus 1

<400>  171

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  172
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain


<220>
<221>  MISC_FEATURE
<222>  (4)..(50)
<223>  These individual amino acid residues may be present or absent

<400>  172

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40                  45              


Arg Arg 
    50  


<210>  173
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain

<400>  173

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  174
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain

<400>  174

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  175
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain

<400>  175

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  176
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain

<400>  176

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  177
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  177

Gly Ser Gly Gly Ser 
1               5   


<210>  178
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  178

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  179
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  179

Gly Gly Gly Ser 
1               


<210>  180
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  180

Gly Gly Ser Gly 
1               


<210>  181
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  181

Gly Gly Ser Gly Gly 
1               5   


<210>  182
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  182

Gly Ser Gly Ser Gly 
1               5   


<210>  183
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  183

Gly Ser Gly Gly Gly 
1               5   


<210>  184
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  184

Gly Gly Gly Ser Gly 
1               5   


<210>  185
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  185

Gly Ser Ser Ser Gly 
1               5   


<210>  186
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  186

Gly Pro Gly Pro 
1               


<210>  187
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  187

Pro Pro Ala Pro Pro Ala 
1               5       


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  188

Pro Pro Pro Gly Pro Pro Pro 
1               5           


<210>  189
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(18)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  These individual nucleotides may be absent

<400>  189
uuunnnnnnn nnnnnnnnuu u                                                 21


<210>  190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  scaffold stem loop sequence

<400>  190
ccagcgacta tgtcgtatgg                                                   20


<210>  191
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  extended stem loop sequence

<400>  191
gcgcttattt atcggagaga aatccgataa ataagaagc                              39


<210>  192
<211>  465
<212>  DNA
<213>  Alpharetrovirus Avian Leukosis virus

<400>  192
atggaagccg tgatcaaggt gatcagctcc gcatgcaaga cctactgtgg caagacgagc       60

ccaagcaaga aggaaatcgg cgctatgctg agcctgctgc agaaggaggg cctcctgatg      120

agcctgtctg atctgtacag cccaggtagc tgggacccta tcaccgccgc cctgacacag      180

agagccatgg tgctgggcaa aagcggcgag ctgaagacat ggggactggt gctgggcgcc      240

ctgaaagccg ctagagaaga gcaagtaacc agcgagcagg ccaagttctg gctgggactg      300

ggcggcggta gagtgagccc ccctggccct gagtgcatcg agaagcctgc caccgagcgg      360

cgcattgaca aaggcgaaga agtgggcgag acaaccgtgc agagagacgc caagatggct      420

ccagaagaga cagcaacccc aaagaccgtg ggcaccagct gctac                      465


<210>  193
<211>  252
<212>  DNA
<213>  Alpharetrovirus Avian Leukosis virus

<400>  193
cactgcggca ccgctatcgg ctgcaactgc gccaccgcca gcgcgcctcc tcccccgtat       60

gtgggcagcg gcctctaccc ctccctggca ggagtgggag agcagcaggg ccagggcgga      120

gatacaccca gaggcgccga gcagcctaga gccgaacccg gccacgccgg ccaggcccct      180

ggccccgccc tgaccgactg ggccagaatc agagaggagc tggcctctac aggccctcca      240

gtggtcgcca tg                                                          252


<210>  194
<211>  23
<212>  RNA
<213>  Unknown

<220>  
<223>  Deltaproteobacter sp.

<400>  194
ccgauaagua aaacgcauca aag                                               23


<210>  195
<211>  750
<212>  DNA
<213>  Alpharetrovirus Avian Leukosis virus

<400>  195
cctgtggtga tcaagaccga gggacctgcc tggacccctc tggaacctaa actgattaca       60

cggctggctg ataccgtcag aaccaagggc ctcagaagcc ccatcacaat ggccgaagtg      120

gaagccctga tgagcagccc actgctgcct cacgacgtga ccaacctgat gcgggtgatc      180

ctgggccccg ccccttacgc cctgtggatg gacgcctggg gcgtgcagct gcaaacagtt      240

atcgccgccg ccacaagaga cccccggcac ccagccaacg gccagggcag aggcgagaga      300

acaaacctgg atcggctgaa gggcctcgcc gatggcatgg ccggcaatcc tgagggccag      360

gctgctctgc tgagacccgg ggaactggtt gctatcaccg ccagcgccct gcaggccttc      420

agagaagtgg cccggctggc cgagcctaca gacccctggg ccgagatcac ccagggccct      480

tctgagagct tcgtggactt cgccaacaga ctgatcaagg ccgttgaggg ctccgacctg      540

cctcctagcg cccgcgcccc cgtgatcatc gactgtttta gacagaaatc gcaacccgac      600

atccagcagc tgatccgggc cgctccttct accctgacca cacctggcga gatcatcaag      660

tacgtgctgg acagacagaa gaccgccccc ctgaccgaca gaggaatcgc cgccgccatg      720

tctagcgcca ttcagcctct ggtgatggcc                                       750


<210>  196
<211>  264
<212>  DNA
<213>  Alpharetrovirus Avian Leukosis virus

<400>  196
gtggtcaaca gagaaagaga tggacagaca ggttctggcg gcagagcccg gggcctgtgc       60

tacacctgcg gatcccctgg acactaccag gcccagtgtc ctaagaaaag aaagtctggt      120

aacagcagag agcggtgcca gctgtgtgat ggcatgggcc acaacgccaa acagtgccgg      180

agacgggacg gaaaccaagg acaaagaccc ggccggggac tgagcagcgg accttggcct      240

gtcagccagc aacctgccgt gtcc                                             264


<210>  197
<211>  26
<212>  RNA
<213>  Unknown

<220>  
<223>  Planctomycetes sp.

<400>  197
ucuccgauaa auaagaagca ucaaag                                            26


<210>  198
<211>  384
<212>  DNA
<213>  Alpharetrovirus Avian Leukosis virus

<400>  198
ctggctatga ccatggaaca caaggaccgg cctctggtgc gggtgatcct gacaaatacc       60

ggctctcacc ccgtgaagca gcggtcagtg tacatcacag ccctgctgga cagcggcgct      120

gatatcacca tcattagcga ggaggactgg cctaccgact ggcccgtgat ggaagctgcc      180

aatccccaga tccacggcat cggaggcgga atcccgatga gaaagtccag agacatgatc      240

gaggtgggcg tgatcaaccg ggacggctct cttgagagac ctctgctgct gttccccgcc      300

gtggctatgg tgcgaggcag catcctgggc cgcgactgcc tgcagggcct gggcctgaga      360

ctgaccaacc tgaactttag ccag                                             384


<210>  199
<211>  465
<212>  DNA
<213>  Alpharetrovirus Rous sarcoma virus

<400>  199
atggaggccg tgatcaaggt gatcagcagc gcatgcaaga cctactgcgg caagaccagc       60

ccatctaaga aagagatcgg cgccatgctg agcctgctcc aaaaggaagg cctgctgatg      120

agcccttccg acctgtacag ccccggaagc tgggacccaa tcaccgctgc cctgacccag      180

cgggccatgg tgctgggaaa gagcggcgag ctgaagacct ggggcctggt gctgggagcc      240

ctgaaggccg ccagagagga acaagtgaca agcgaacagg ccaagttctg gctgggactg      300

ggcggaggaa gagtcagccc tcctggccca gagtgcatcg agaagcccgc tacagagaga      360

agaatcgata agggcgaaga ggtgggcgag acaacagtgc agagagacgc caagatggct      420

cctgaggaaa ccgccacacc taagaccgtg ggcacatctt gttac                      465


<210>  200
<211>  252
<212>  DNA
<213>  Alpharetrovirus Rous sarcoma virus

<400>  200
cactgcggca ccgccattgg atgtaactgc gctacagcca gcgccccccc ccctccctac       60

gtgggcagcg gactttatcc tagcctggcc ggcgtgggag agcagcaggg ccaaggcgga      120

gatacaccca gaggcgccga gcagcctaga gccgaacccg gccacgccgg actggcccct      180

ggcccagccc tgaccgactg ggcccgcatc cgggaagaac tggcttctac cggccccccg      240

gtggtcgcca tg                                                          252


<210>  201
<211>  267
<212>  DNA
<213>  Alpharetrovirus Rous sarcoma virus

<400>  201
gccgtggtga acagagagag agacggccag acaggctccg gcggccgggc cagagagctg       60

tgctacacct gtggctctcc aggccactac caggctcagt gtcctaaaaa gcggaagtct      120

ggcaattcta gagagcggtg ccagctgtgc aacggcatgg gccataatgc caaacagtgt      180

cggaaacggg acggaaacca gggccagaga ccaggcagag gcctgtcttc tggcccctgg      240

cccggccctg agcctcctgc tgtgtcc                                          267


<210>  202
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold stem loop

<400>  202
ccagcgacua ugucguagug g                                                 21


<210>  203
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(28)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(28)
<223>  These individual nucleotides may be absent

<400>  203
uuunnnnnnn nnnnnnnnnn nnnnnnnnuu u                                      31


<210>  204
<211>  19
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  204
acaugaggau uacccaugu                                                    19


<210>  205
<211>  18
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  205
ugcaugucua agacagca                                                     18


<210>  206
<211>  20
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  206
aauccauugc acuccggauu                                                   20


<210>  207
<211>  12
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  207
ccucuucgga gg                                                           12


<210>  208
<211>  21
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  208
aggaguuucu auggaaaccc u                                                 21


<210>  209
<211>  30
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  209
aggugggacg accucucggu cguccuaucu                                        30


<210>  210
<211>  19
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  210
ugcucgcucc guucgagca                                                    19


<210>  211
<211>  21
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  211
ugcucgacgc guccucgagc a                                                 21


<210>  212
<211>  22
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  212
ugcucguuug cggcuacgag ca                                                22


<210>  213
<211>  17
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  213
agggagggag ggagagg                                                      17


<210>  214
<211>  19
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  214
gguuaggguu aggguuagg                                                    19


<210>  215
<211>  25
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  215
cugcucagua cgagaggaac cgcag                                             25


<210>  216
<211>  78
<212>  RNA
<213>  Unknown

<220>  
<223>  exogenous stem loop region

<400>  216
uacacuggga ucgcugaauu agagaucggc guccuuucau ucuauauacu uuggaguuuu       60

aaaaugucuc uaaguaca                                                     78


<210>  217
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  217

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  218
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  218

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  219
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  219

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn His Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  220
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  220

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Ala 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  221
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  221

Arg Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Ala Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala 
225                 230                 235                 240 


Ser Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val 
                245                 250                 255     


Val Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly 
            260                 265                 270         


Lys Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His 
        275                 280                 285             


Thr Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg 
    290                 295                 300                 


Met Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp 
305                 310                 315                 320 


Asp Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu 
                325                 330                 335     


Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn 
            340                 345                 350         


Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp 
        355                 360                 365             


Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu 
    370                 375                 380                 


Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln 
385                 390                 395                 400 


Leu Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp 
                405                 410                 415     


Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu 
            420                 425                 430         


Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp 
        435                 440                 445             


Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser 
    450                 455                 460                 


Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg 
465                 470                 475                 480 


Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro 
                485                 490                 495     


Phe Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser 
            500                 505                 510         


Lys Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys 
        515                 520                 525             


Leu Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg 
    530                 535                 540                 


Phe Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr 
545                 550                 555                 560 


Val Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe 
                565                 570                 575     


Asn Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys 
            580                 585                 590         


Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr 
        595                 600                 605             


Gly Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr 
    610                 615                 620                 


Asn Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr 
625                 630                 635                 640 


Phe Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn 
                645                 650                 655     


Leu Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu 
            660                 665                 670         


Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly 
        675                 680                 685             


Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln 
    690                 695                 700                 


Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly 
705                 710                 715                 720 


Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met 
                725                 730                 735     


Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp 
            740                 745                 750         


Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly 
        755                 760                 765             


Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp 
    770                 775                 780                 


Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  222
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  222

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Gln Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  223
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  223

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Thr Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  224
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  224

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Arg Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  225
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  225

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Tyr Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  226
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  226

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  227
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  227

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Ala Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  228
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  228

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  229
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  229

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  230
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  230

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  231
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  231

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Asn Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  232
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  232

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Trp Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  233
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  233

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Tyr Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  234
<211>  393
<212>  DNA
<213>  Alpharetrovirus Rous sarcoma virus

<400>  234
ctggctatga ccatggaaca caaggacaga cccctggtgc gggtgatcct gacaaacacc       60

ggaagccacc ccgtgaagca gcgctccgtg tacatcacag cccttctgga cagcggcgcc      120

gacatcacca tcatcagcga ggaagattgg cctacagact ggcctgtgat ggaagccgca      180

aacccccaga tccacggcat cggcggaggt atacccatgc ggaagagcag agacatgatc      240

gagctgggcg tgatcaaccg ggacggcagc ctggaacggc ccctgctgtt gtttcctgct      300

gtggctatgg tgcggggaag catcctgggc agagattgcc tgcagggcct gggcctgcgc      360

ctgaccaacc tgtgaggagg gccactgttc tca                                   393


<210>  235
<211>  270
<212>  DNA
<213>  Betaretrovirus enzootic nasal tumor virus

<400>  235
atgggccaga cccacagcag acaactgttc gtgcacatgc tgtccgtgat gctgaagcac       60

agaggcatca ccgtgtctaa gcctaagctg atcaacttcc tgagcttcat cgaggaagtg      120

tgtccttggt ttccacggga aggcacagtg aacctggaaa catggaaaaa ggtgggcgaa      180

cagatcagaa cccactacac cctgcacggc cctgagaagg tgcctgtgga aacactttcc      240

ttctggaccc tgatccgcga ctgcctggat                                       270


<210>  236
<211>  546
<212>  DNA
<213>  Betaretrovirus enzootic nasal tumor virus

<400>  236
ttcgacaatg acgagctgaa aagactgggc aacctgctca agcaggagga agatcctctg       60

cacgaccctg acagcgagaa cagctacgac gcccctcctc ctcctcatcc tagcctgcac      120

tctagcagac cttccgacaa cgacgacctg ctgtctagca cagacgaggc cgagctggac      180

gaggaagccg ccaagtacca ccaggaggac tggggcttcc tggctcagga gaaaggcgcc      240

ctgacaagca aggacgagct ggtggaatgt ttcaagaacc tgaccatcgc cctgcagaac      300

gctggaatca agctgccagc caacaacgat aagttcccct ccgccccccc tctgcctcct      360

gcctacgccc ctagcgtggt ggccggactg gatccacccc ccggccccct gcccccaagc      420

aagaacatgt ctccactgca gaaagccctg agacaagccc agaggctggg cgaagttgtg      480

tccgatttca gcctggcctt ccccgtgttc gagaacaaca accagcggta ctacgagagc      540

ctgcct                                                                 546


<210>  237
<211>  618
<212>  DNA
<213>  Betaretrovirus enzootic nasal tumor virus

<400>  237
ttcaagcagc tgaaggaact caaaatcgca tgcagccagt acggccctac cgcacctttt       60

accatcgcca tgatcgagaa cctcggcacc caggccctgc cacctaatga ttggaagcag      120

acagccagag cctgcctgtc aggcggagat tacctgctgt ggaagagcga gttcttcgag      180

caatgcgcca gaatcgctga cgtgaaccgg cagcagggca tccagacgag ctacgagatg      240

ctgatcggcg agggacccta ccaggccacc gacacccagc tgaacttcct gcctggggcc      300

tatgcccaaa tcagcaacgc cgccagacag gcttggaaga aactgcctag ctcttctaca      360

aagaccgagg acctgagcaa agtgcggcaa ggccccgatg agccctacca ggactttgtc      420

gccagactgc tcgacaccat cggcaagatc atgagcgacg aaaaggccgg catggtcctg      480

gctaagcaac tggctttcga gaatgctaat agcgcctgtc aggccgccct gcggccttac      540

agaaagaagg gcgacctgtc cgattttatc agaatctgcg ccgacatcgg cccctcttat      600

atgcagggaa ttgccatg                                                    618


<210>  238
<211>  405
<212>  DNA
<213>  Betaretrovirus enzootic nasal tumor virus

<400>  238
gccgctgctc tgcagggcaa aagcatcaag gaagtgcttt tccagcagca agctcggaac       60

aagcggggaa gacagagaag cggcaatagc ggttgttttg tgtgcggcca gcccggccac      120

cgcgccgccg tgtgccccca gaagcagcag agccccgtga acacccctaa tctgtgcccg      180

cgctgtaaaa aaggaaagca ttgggcacga gattgccggt ccaaaacaga tgttcaaggt      240

acccctttac ccccggtgtc gggaaactgg gtgaggggcc agcccctggc cccgaaacaa      300

tgttatgggg caacactgca ggttccaaaa gaaccattgc agacctctgt cgagccacaa      360

gaggcagcgc gggattggac ctctgtgcca cctcctacac agtat                      405


<210>  239
<211>  999
<212>  DNA
<213>  Betaretrovirus enzootic nasal tumor virus

<400>  239
aaaaggaaag cattgggcac gagattgccg gtccaaaaca gatgttcaag gtaccccttt       60

acccccggtg tcgggaaact gggtgagggg ccagcccctg gccccgaaac aatgttatgg      120

ggcaacactg caggttccaa aagaaccatt gcagacctct gtcgagccac aagaggcagc      180

gcgggattgg acctctgtgc cacctcctac acagtattaa ctcccgagat gggggtccaa      240

accctggcta caggcgtgtt cggtcctctg ccccccggca ccgccggcct gctgctgggc      300

agaagcagcg ccagcctgaa gggcatcctg atccatcctg gagtgattga cagcgactac      360

accggcgaga tcaagatcct ggcctctgcc cctaacaaga tcatcgtgat caacgccggc      420

caaagaatcg cccagctgct gctcgtgcct ctggtgatcc agggcaaaac catcaaccgg      480

gacaggcagg acaagggatt tggatcttct gacgcctatt gggtgcagaa cgtgaccgag      540

gccagacctg aactggaact tagaatcaat ggcaagctgt tccggggcgt gctggataca      600

ggcgccgaca tcagcgtgat cagcgacaaa tactggccca ccacctggcc taagcagatg      660

gctatctcta cactgcaggg catcggccag acaaccaacc ccgagcagag cagcagcctg      720

ctgacctgga aggacaagga cggccacacc ggccaattca agccctacat cctgcctcac      780

ctgcctgtga acctgtgggg cagagatatc ctgagcaaga tgggcgtcta cctgtactcc      840

cctagcccta ccgtgacaga tctgatgctg gaccagggcc tgctgcctaa tcagggcctc      900

ggaaagcaac accagggaat tatcctgcca ctggacctga aaagcaacca ggatagaaag      960

ggcctgggat gcttcccctg aggacctctg attctcctg                             999


<210>  240
<211>  297
<212>  DNA
<213>  Betaretrovirus mouse mammary tumor virus

<400>  240
atgggcgtgt ccggctcaaa gggccagaag ctgtttgtgt ccgtgctgca gcgtctgctg       60

tccgaacggg gcctacacgt gaaagagagc agcgccatcg agttctacca gtttctgatc      120

aaggtgtcac cctggttccc cgaggaaggc ggcctgaatc tgcaggattg gaagagagtg      180

ggcagagaaa tgaagaagta cgccgctgag cacggcaccg acagcatccc caagcaggct      240

tatcctatct ggctgcaact gagagagatc ctgacagagc aatctgacct ggtgctg         297


<210>  241
<211>  288
<212>  DNA
<213>  Betaretrovirus mouse mammary tumor virus

<400>  241
ctgagcgccg aggccaagtc cgtgacagag gaagaactgg aagaaggcct gacaggactg       60

ctgagcgcca gcagccagga gaagacctac ggcacaagag gcaccgccta tgccgaaatc      120

gacaccgagg tggataagct gagcgagcac atctacgacg agccctacga ggagaaggaa      180

aaggccgaca agaacgagga gaaggaccac gtgcggaagg tcaagaagat cgtgcaaaga      240

aaggaaaata gcgagcataa gagaaaggag aaagatcaga aggccttc                   288


<210>  242
<211>  222
<212>  DNA
<213>  Betaretrovirus mouse mammary tumor virus

<400>  242
ctggcaaccg actggaacaa cgacgacctg agccctgagg actgggacga cctggaagag       60

caggccgccc actaccacga tgacgacgaa ctgatcctgc ctgtgaagag aaaggtggac      120

aagaagaagc cgctcgccct gaggcggaaa cctctgcccc cggttggctt cgccggagcc      180

atggccgagg ctagagagaa gggcgatctg accttcacat tt                         222


<210>  243
<211>  681
<212>  DNA
<213>  Betaretrovirus mouse mammary tumor virus

<400>  243
cccgtggttt tcatgggaga atccgacgac gatgataccc ctgtgtggga acctctgccc       60

ctgaagacac tgaaggaact gcagtctgcc gtgcggacca tgggccctag cgccccttac      120

accctccagg tggtggacat ggttgcctct cagtggctga cacctagcga ttggcaccaa      180

accgccagag ccaccctgtc tcctggggac tacgtgctgt ggcggaccga gtacgaggag      240

aagagcaagg aaaccgtgca gaagaccgct ggcaagcgga aaggcaaggt gagcctggat      300

atgctgctgg gcacaggtca gttcctgagc ccttcttctc agatcaagct ttctaaagat      360

gtgctgaagg atgtgaccac caacgccgtc ctggcctgga gagccatccc tcctccaggc      420

gtcaaaaaga cagtgctggc cggactcaag cagggaaatg aggaaagcta cgagacattc      480

atcagcagac tggaagaggc cgtgtacaga atgatgccta gaggagaagg cagcgacatc      540

ctgatcaagc agctggcttg ggagaacgct aattctctgt gccaggacct gatccggcct      600

atgcggaaga ccggcaccat gcaggactac atcagagcct gtctggatgc ctcccctgcc      660

gtggtgcagg gcatggccta c                                                681


<210>  244
<211>  723
<212>  DNA
<213>  Betaretrovirus mouse mammary tumor virus

<400>  244
gccgccgcaa tgagaggaca aaagtacagc accttcgtga aacagacata cggcggcgga       60

aaaggcggac agggctctga aggccctgtg tgcttcagct gcggcaaaac aggtcacatt      120

aagcgggatt gcaaggaaga gaaaggaagc aagcgcgctc ctcctggact gtgtcctaga      180

tgcaagaaag gctaccactg gaagagcgag tgcaagagca agttcgacaa ggacggcaac      240

cctctgccac cactggaaac taacgccgaa aacagcaaaa accccacaca gaaaggcgac      300

aaaggaaagg acagcggact gaaccccgaa gcccctcctt tcaccatcca cgacctgcca      360

cgaggcaccc caggcagtgc cggcttggac ctgagcagcc agaaagacct gatcctgtct      420

ctggaagacg gcgtgtccct ggtgccaacc ctggtgaagg gcaccctgcc cgagggcacc      480

acgggactga tcatcggcag atccagcaac tacaagaaag gcctggaggt gctgcccggc      540

gtgatcgact ccgacttcca gggcgaaatt aaggtcatgg taaaggccgc taagaacgcc      600

gtgatcatcc acaagggcga gcggatcgcg cagctgctgc tgctgcctta tctgaaactg      660

cctaacccta tcatcaagga ggaaagaggc agcgagggat ttggcagcac ctcccacgtg      720

cac                                                                    723


<210>  245
<211>  360
<212>  DNA
<213>  Betaretrovirus mouse mammary tumor virus

<400>  245
tgggtgcagg agatcagcga cagcagaccc atgctgcaca tcagcctgaa cggcagaaga       60

ttcctgggcc tgctggacac cggggccgat aagacctgca tcgccggcag agattggccc      120

gccaactggc ctattcacca gaccgagagc agcctgcagg gcttgggaat ggcttgtggc      180

gtggctagaa gctctcagcc tctgagatgg cagcacgagg ataagtctgg cattatccat      240

cctttcgtga tccccacatt gccttttacc ctctggggcc gggacatcat gaaagagata      300

aaggtgcggc tgatgaccga tagcccagac gacagccagg atctgacatc tctgtacggc      360


<210>  246
<211>  300
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  246
atgggccagg agctgtccca gcacgagcgg tacgtggagc agctgaagca agcccttaaa       60

acaagaggcg tgaaggtgaa atacgccgac ctgctgaagt tcttcgattt tgtgaaggat      120

acctgccctt ggttccctca ggagggcacc atcgacatca agagatggcg cagagtgggc      180

gactgcttcc aagattacta caacaccttc ggacctgaga aagtgcctgt gaccgccttc      240

agctactgga acctgatcaa ggaactgatc gacaaaaagg aagtgaaccc acaggtgatg      300


<210>  247
<211>  348
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  247
gctgctgtcg cccagaccga ggaaatcctg aagagcaaca gccagacaga cctgaccaag       60

accagccaga accctgacct ggatctgatc agcctggaca gcgatgatga gggcgccaag      120

tccagcagcc tgcaggacaa gggcctgagc agcaccaaaa agcctaagcg gttccccgtc      180

ctgctgaccg cccagacaag caaggaccca gaggatccta acccaagcga ggtggactgg      240

gacggcctgg aggacgaggc cgctaagtac cacaaccctg actggccccc cttcctgaca      300

agacctccac cttacaacaa ggctacccct agcgccccta ccgtgatg                   348


<210>  248
<211>  249
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  248
gccgtggtga accctaaaga ggaactgaaa gaaaagatcg cccagctgga agagcagatc       60

aaactggaag agctgcacca ggccctgatt tctaagctgc aaaagctgaa aaccggcaac      120

gagacagtca ctcaccctga tacagccgga ggcctgagca gaacaccaca ttggcccggc      180

cagcacatcc ctaagggcaa gtgctgcgcc agccgggaaa aggaagagca gatccccaag      240

gatatcttc                                                              249


<210>  249
<211>  678
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  249
cctgtgaccg aaaccgttga cggacagggc caggcatgga gacaccacaa tggcttcgac       60

ttcgccgtga tcaaggaact gaagacagcc gcctctcaat acggcgccac cgcaccttac      120

accctggcta tcgtggaatc cgtcgccgac aactggctga ccccaaccga ctggaatacc      180

ctggtgcggg ccgtgctgtc tggcggcgac cacctgctct ggaagtctga gttcttcgag      240

aactgtaggg acaccgctaa gcggaaccag caggccggca atggatggga ttttgacatg      300

ctgaccggca gcggcaacta cagctctaca gacgcccaaa tgcagtacga ccctggcctg      360

ttcgcccaga ttcaggccgc tgccacaaag gcctggcgga agctgcccgt gaagggggat      420

cccggcgcca gcctgaccgg cgtgaagcag ggccccgatg agcctttcgc cgacttcgtg      480

catagactga tcaccacagc cggcagaatc ttcggctccg ccgaagccgg cgtggactac      540

gtgaagcagc tggcttacga gaacgccaac cctgcctgcc aggccgcaat cagaccctat      600

agaaagaaga cagatctgac cggctacatc cggctgtgca gcgacatcgg cccttcctat      660

cagcagggac tggctatg                                                    678


<210>  250
<211>  694
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  250
gccgctgcct ttagcggcca gaccgtgaag gacttcctga acaacaagaa caaggaaaag       60

ggcggatgtt gttttaagtg cggcaagaaa ggacactttg ccaaaaactg ccacgagcac      120

gcccacaaca acgccgagcc caaggtgccc ggcctgtgtc ctcggtgcaa gagaggcaag      180

cactgggcca atgagtgcaa gtccaagaca gataaccagg gaaatccaat ccccccccat      240

cagggaaatg gtgcttctcc tagacctaga aacaagctga tgggccaaag cgccctgttc      300

cagcctacca agacaaccca cttcaaggcc taccagagcc accccagaaa gtgcagaatc      360

ggccctctgt tccacctgcc ccacagcatc aacgcctgaa atggggcccc aagcgttaag      420

cactggaata tatggaccac tgcctcccaa cacttttgga ttaatcctag gccgaagtag      480

cattactatg aagggtctac aagtttatcc aggagtaatt gataatgact ataccggaga      540

aattaaaatt atggcaaaag ctgttaacaa tattgttact gtctctcaag gcaacagaat      600

agctcaatta atcctcctgc ctctgatcga gacagacaat aaggtacaac aaccttatag      660

aggacaagga agttttggat cctcagacat atat                                  694


<210>  251
<211>  459
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  251
tgggtccagc ctatcacctg tcagaagcct tctctgaccc tgtggctgga cgacaagatg       60

ttcaccggcc tcatcgacac cggcgccgac gtgacaatca tcaagctgga agattggcct      120

ccaaattggc ccattacaga taccctgacc aacctgagag gcatcggaca gtccaacaac      180

cccaagcaga gcagcaagta cctgacatgg cgggacaagg agaacaacag cggcctgatc      240

aaaccttttg tgatccccaa tctgcctgtg aacctgtggg gaagagatct gctgtctcag      300

atgaagatca tgatgtgcag cccaaacgac atcgtgaccg cccagatgct ggctcaaggc      360

tacagccccg gcaaaggcct gggcaagaaa gagaatggaa tcctgcaccc tatccctaac      420

cagggccaga gcaacaagaa gggcttcggc aacttctga                             459


<210>  252
<211>  300
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  252
atggggcaag aattaagcca gcatgaacgt tatgtagaac aattgaagca ggctttaaag       60

acacggggag taaaggttaa atatgctgat cttttgaaat tttttgattt tgtgaaggat      120

acttgtcctt ggtttccgca agagggaacc atagatatta aacggtggcg tagagtaggc      180

gactgtttcc aagactatta caatactttt ggcccggaga aagtcccagt aactgcattc      240

tcttactgga acttaattaa agaattgata gataagaaag aagttaaccc acaagtaatg      300


<210>  253
<211>  348
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  253
gctgccgtag cccaaactga agaaatttta aaaagtaatt ctcaaacaga cctcacaaag       60

acctctcaaa acccagactt ggaccttatt tcccttgata gcgacgatga aggagctaaa      120

agttcctctc tacaagataa aggtttatca agtactaaaa aaccaaaaag attcccagtt      180

ctgttaacag cacaaactag taaagaccct gaagacccca acccctcaga ggtagactgg      240

gacggcttgg aagatgaggc agcgaaatat cataatcccg attggcctcc cttcctaacc      300

cgtccacctc cttacaataa agctactcct tccgcaccca ctgtaatg                   348


<210>  254
<211>  249
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  254
gcggttgtta atccaaaaga ggagctcaaa gaaaaaattg ctcaattaga ggaacagatt       60

aaattagaag agttacacca ggcactaatt tccaaattac aaaaactaaa aacagggaat      120

gaaactgtaa ctcacccaga cacagcagga ggcctttctc gcacgcctca ctggccaggg      180

caacatatcc ctaaaggaaa atgttgcgcc agtcgagaaa aggaagaaca aatcccaaaa      240

gatattttc                                                              249


<210>  255
<211>  678
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  255
ccagtgactg aaaccgttga tgggcaaggt caagcctgga gacaccataa tggttttgat       60

tttgccgtca taaaagaatt aaaaacagct gcttcccaat atggggctac tgccccatac      120

acattagcca tagtggaatc tgtagcggac aattggctta cccctacaga ttggaatacg      180

cttgttaggg cagtcctctc aggaggagat cacttactgt ggaaatctga gttttttgaa      240

aattgcagag atacggctaa aagaaaccaa caagccggta atggctggga ttttgacatg      300

ttaacaggtt cgggtaatta ttccagcacc gatgcacaaa tgcagtatga tccaggattg      360

tttgctcaaa ttcaagcggc tgctacaaaa gcctggagaa aacttcccgt taagggagac      420

ccaggagcct cccttacagg agtcaaacaa ggacccgatg agccatttgc agatttcgta      480

cacagactta taacaactgc tgggagaatc tttggaagtg ctgaggccgg tgtagactat      540

gtaaaacaac tagcatatga aaatgctaat ccagcttgtc aggcagccat tcgcccctat      600

agaaagaaga cagatttaac tggctatatc cgtctttgct cggatattgg gccctcttat      660

cagcaaggcc tggccatg                                                    678


<210>  256
<211>  694
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  256
gccgccgcct ttagcgggca gactgtaaaa gattttctta acaacaaaaa taaagagaaa       60

ggagggtgtt gctttaaatg cggtaaaaaa ggacactttg caaaaaattg tcatgaacat      120

gcacataaca atgctgaacc aaaagttccc ggactctgcc ctagatgtaa aagagggaaa      180

cattgggcca atgaatgcaa atccaaaact gataatcaag gaaacccaat accaccccat      240

cagggaaacg gggccagccc caggccccga aacaagctta tggggcagtc agctttgttc      300

cagccaacaa aaacaaccca tttcaaagct taccagagcc accccaggaa gtgcaggatt      360

ggacctctgt tccacctccc acacagtatt aacgcctgaa atggggcccc aagcgttaag      420

cactggaata tatggaccac tgcctcccaa cacttttgga ttaatcctag gccgaagtag      480

cattactatg aagggtctac aagtttatcc aggagtaatt gataatgact ataccggaga      540

aattaaaatt atggcaaaag ctgttaacaa tattgttact gtctctcaag gcaacagaat      600

agctcaatta atcctcctgc ctctgatcga gacagacaat aaggtacaac aaccttatag      660

aggacaagga agttttggat cctcagacat atat                                  694


<210>  257
<211>  459
<212>  DNA
<213>  Betaretrovirus Mason-Pfizer monkey virus

<400>  257
tgggtccaac ctattacttg tcaaaaacct tccttaacat tatggttaga tgacaaaatg       60

ttcacaggct taatagatac gggggctgat gtcacaatta tcaagctgga ggactggcct      120

cctaattggc ctataacaga taccttaacc aatttaagag gaataggaca aagtaacaac      180

cctaaacaaa gttctaaata tcttacttgg agagataaag aaaacaattc tggtctcatc      240

aaaccgtttg ttattcctaa cttacctgtc aatctttggg gccgagattt actttctcaa      300

atgaaaatta tgatgtgtag ccccaatgac atagtaactg ctcaaatgtt agcccagggc      360

tacagcccag gaaaagggtt aggaaaaaag gaaaatggca ttctacatcc tatcccaaat      420

caaggacaat ctaacaaaaa aggttttgga aatttttaa                             459


<210>  258
<211>  327
<212>  DNA
<213>  Deltaretrovirus Bovine leukemia virus

<400>  258
atgggcaact ctcctagcta caatccccct gccggcatct ccccatctga ctggctgaac       60

ctgctgcagt ccgcccagcg cctgaatcca aggcctagcc catccgactt cacagatctg      120

aagaactata tccactggtt tcacaagacc cagaagaagc cttggacctt cacaagcgga      180

ggaccaacat cctgcccacc aggcagattt ggaagggtgc cactggtgct ggccaccctg      240

aacgaggtgc tgtccaatga gggaggagca cctggagcct ctgccccaga ggagcagcct      300

ccaccctacg accctccagc catcctg                                          327


<210>  259
<211>  639
<212>  DNA
<213>  Deltaretrovirus Bovine leukemia virus

<400>  259
cccatcatct ccgagggaaa caggaatagg cacagggcat gggcactgag ggagctgcag       60

gatatcaaga aggagatcga gaataaggcc cctggctctc aagtgtggat ccagacactg      120

cggctggcca tcctgcaggc agacccaacc cctgcagatc tggagcagct gtgccagtac      180

atcgccagcc ctgtggacca gaccgcccac atgacatccc tgaccgcagc aatcgcagca      240

gcagaggcag caacacccag cagagtgctg acccctaaga ccggcacact gacccagcag      300

tctgcccagc caaacgcagg cgatctgagg agccagtatc agaatctgtg gctgcaggcc      360

ggcaagatct ccctgctggt gctgcagctg cagccctggt ctaccatcgt gcagggacct      420

gcagagagct ccgtggagtt tgtgaaccgc ctgcagatct ccctggccga caacctgcca      480

gatggcgtgc tgcggaatcc cctgctgaca cctctggtca tgcagatgct gaccgagtct      540

gtgagcaagt tctgcagggg agaggccagc ggaaggggag gagccaagac agcaggactg      600

agaaccatcg gaccacctag gatgaagcag cctgccctg                             639


<210>  260
<211>  291
<212>  DNA
<213>  Deltaretrovirus Bovine leukemia virus

<400>  260
ctggtgcaca ccccaggacc aaagatgcct ggaccacgcc agccagcacc taagaggcca       60

ccacctggac cttgctacag atgtctgaag gagggacact gggccaggga ctgcccaaca      120

aaggcaaccg gcccaccacc tggaccatgc cccatctgta aggacccaag ccactggaag      180

cgcgattgtc ccacactgaa gtccaagaat ctaatagagg ggggacttag cgccccccaa      240

accataacac ctataacaga ttctcttagt gaggccgaat tagaatgctt a               291


<210>  261
<211>  378
<212>  DNA
<213>  Deltaretrovirus Bovine leukemia virus

<400>  261
ctctctattc ctctggcccg gagccgccct agcgtggccg tgtacctgag cggcccttgg       60

ctgcaacctt ctcagaacca ggccctgatg ctggttgata caggcgccga gaacaccgtg      120

ctgcctcaga attggctggt gcgggactac cccagaatcc ctgccgctgt gctgggagcc      180

ggaggcgtgt cccggaacag atacaactgg ctgcagggcc ctcttacact ggctctgaaa      240

cctgaaggcc cattcatcac catcccaaag atcctggtcg acaccttcga caagtggcag      300

atcctgggca gagatgtgct gagcagactg caggccagca tcagcatccc cgaggaagtg      360

cggccccccg tggtgggc                                                    378


<210>  262
<211>  40
<212>  DNA
<213>  Deltaretrovirus Bovine leukemia virus

<400>  262
aggtgcccca gccatcctgc ccatcatctc cggcggcagc                             40


<210>  263
<211>  390
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  263
atgggtcaga ttttcagcag aagcgcctcc cctattccta gacctccacg gggcctggcc       60

gcccaccact ggctgaattt cctgcaggcc gcttatagac tggagcctgg accttccagc      120

tacgacttcc accagctgaa gaaattcctg aagatcgccc tggaaacccc tgccagaatc      180

tgccctatca actacagcct gctggcctcc ctgctgccca agggctaccc tggcagagtg      240

aacgagatcc ttcatatcct gatccagaca caggctcaga tcccctctag gcccgctcca      300

cctcctccaa gcagcccaac ccacgatcct cctgatagcg accctcagat ccccccacca      360

tacgtggagc ccaccgcccc tcaagtgctg                                       390


<210>  264
<211>  642
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  264
ccagtgatgc acccccacgg cgcccctcct aatcacagac cttggcagat gaaagacctg       60

caggccatca agcaggaagt gtcccaggcc gctcctggca gcccccaatt tatgcagacc      120

atcagactcg ccgttcagca gttcgacccc acagccaagg atctgcagga cctgctgcag      180

tacctgtgta gcagcctggt cgccagcctg caccatcagc aactggattc tctgatcagc      240

gaggccgaga caagaggcat caccggctac aaccctctgg ccggccccct gcgggtgcag      300

gcaaacaacc cccagcagca ggggctgcgg agagagtacc agcagctgtg gctggctgct      360

ttcgccgcac tgcctggaag cgccaaagat ccatcttggg cctctatcct gcagggcctg      420

gaagaacctt accacgcctt tgtggaaaga ctgaacatcg ccctggacaa cggcctgcct      480

gagggcaccc ctaaggaccc catcctgaga tctctggcct acagcaacgc caacaaggaa      540

tgtcagaagc tgctgcaagc cagaggccac accaacagcc ccctgggcga catgctgcgc      600

gcctgccaga cctggacccc taaggacaag accaaggtgc tg                         642


<210>  265
<211>  314
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  265
gtggtgcagc ctaagaagcc tccccctaat cagccctgct tccggtgcgg caaggccgga       60

cactggagcc gggactgcac ccagcctcgg cctccaccgg gaccttgtcc tctgtgccaa      120

gaccccacac actggaagag agattgcccc cgcctaaagc ccactatccc agaaccagag      180

ccagaggaag atgccctcct attagacctc cccgctgaca ttccacaccc aaaaaactcc      240

ataggggggg aggtttaacc tctcctccta ccctgcagca ggtgttcctg aatcaagatc      300

ctgccagcat cctg                                                        314


<210>  266
<211>  546
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  266
acctcccacc ccaaaacaat cgaggccctg ctggacaccg gcgctgatat gacagtgctg       60

ccaatcgccc tgttcagcag caacacccct ctgaaaaaca ccagcgtgct cggagccggc      120

ggacagaccc aggaccactt caagctgaca agcctgcctg tcctgatccg gctgcccttc      180

agaaccacac ctatcgtgct gaccagctgc ctggtggaca caaagaacaa ctgggccatc      240

atcggcaggg acgccctgca acagtgccag ggcgtgctgt acctgccaga ggccaagggc      300

ccccccgtta tcctgcctat ccaggcccct gccgtgctgg gcctggaaca cctgccaaga      360

cccccccaga tcagccaatt tcctctgaac cagaacgcca gcagaccatg taatacctgg      420

tccggcagac cttggcggca ggccatttct aaccccaccc ccggccagga gatcacccag      480

tacagccagc tgaagcggcc tatggaacct ggagattcta gcaccacctg cggccctctg      540

acactg                                                                 546


<210>  267
<211>  39
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  267
ggtgcccctc aagtgctgcc agtgatgcac ggcggcagc                              39


<210>  268
<211>  390
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  268
atgggccaaa tcttttcccg tagcgctagc cctattccgc gaccgccccg ggggctggcc       60

gctcatcact ggcttaactt cctccaggcg gcatatcgcc tagaacccgg tccctccaat      120

tgcgctttcc acctgttaag aagatatcat gaaacagttt ccggaatacc ggctcggatc      180

tgtcccatta actactccct cctagccagc ctactcccaa aaggataccc cggccgggtg      240

aatgaaattt tacacatact catccaaacc caagcccaga tcccgtcccg tcccgcgcca      300

ccgccgccgt catcccccac ccacgacccc ccggattctg atccacaaat cccccctccc      360

tatgttgagc ctacggcccc ccaagtcctt                                       390


<210>  269
<211>  642
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  269
ccagtcatgc atccacatgg tgctcctcct aaccatcgcc catggcaaat gaaagaccta       60

caggccatta agcaagaagt ctcccaagca gcccctggga gcccccagtt tatgcagacc      120

atccggcttg cggtgcagca gtttgacccc actgccaaag acctccaaga cctcctgcag      180

tacctttgct cctccctcgt ggcttccctc catcaccagc agctagatag ccttatatca      240

gaggccgaaa cccgaggtat tacaggttat aacccattag ccggtcccct ccgtgtccaa      300

gccaacaatc cacaacaaca aggattaagg cgagaatacc agcaactctg gctcgccgcc      360

ttcgccgccc tgccggggag tgccaaagac ccttcctggg cctctatcct ccaaggcctg      420

gaggagcctt accacgcctt cgtagaacgc ctcaacatag ctcttgacaa tgggctgcca      480

gaaggcacgc ccaaagaccc catcttacgt tccttagcct actccaatgc aaacaaagaa      540

tgccaaaaat tactacaggc ccgaggacac actaatagcc ctctaggaga tatgttgcgg      600

gcttgtcaga cctggacccc caaagacaaa accaaagtgt ta                         642


<210>  270
<211>  314
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  270
gttgtccagc ctaaaaaacc ccccccaaat cagccgtgct tccggtgcgg gaaagcaggc       60

cactggagtc gggactgcac tcagcctcgt cccccccccg ggccatgccc cctatgtcaa      120

gacccaactc actggaagcg agactgcccc cgcctaaagc ccactatccc agaaccagag      180

ccagaggaag atgccctcct attagacctc cccgctgaca ttccacaccc aaaaaactcc      240

ataggggggg aggtttaacc tcccccccca cattacagca agtctttctt aaccaagacc      300

cagcatctat tctg                                                        314


<210>  271
<211>  606
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  271
ccagttatac cgttagatcc cgcccgtcgg cccgtaatta aagcccaggt tgacacccag       60

accagccacc caaagactat cgaagctcta ctagatacag gagcagacat gacagtcctt      120

ccgatagcct tgttctcaag taatactccc ctcaaaaata catccgtatt aggggcaggg      180

ggccaaaccc aagatcactt taagctcacc tcccttcctg tgctaatacg cctccctttc      240

cggacaacgc ctattgtttt aacatcttgc ctagttgata ccaaaaacaa ctgggccatc      300

ataggtcgcg atgccttaca acaatgccag ggcgtcctgt acctccctga ggcaaaaggg      360

ccgcctgtaa tcttgccaat acaggcgcca gccgtccttg gactagaaca cctcccaagg      420

cccccccaaa tcagccagtt ccctttaaac cagaacgcct ccaggccttg caacacttgg      480

tccggaaggc cctggaggca ggccatatcg aatcctacac cgggccagga aataacccag      540

tattcccagt taaaaaggcc aatggaacct ggcgattcat ccacgacctg cgggccacta      600

actctc                                                                 606


<210>  272
<211>  36
<212>  DNA
<213>  Deltaretrovirus human T-lymphotropic virus

<400>  272
gcccctcaag tgctgccagt gatgcacggc ggcagc                                 36


<210>  273
<211>  285
<212>  DNA
<213>  Epsilonretrovirus Walleye dermal sarcoma virus

<400>  273
atgggcaata gctcctctac cccccctcca agcgccctga agaactccga tctgttcaag       60

accatgctga ggacacagta cagcggctcc gtgaagacac ggagaatcaa ccaggatatc      120

aagaagcagt atccactgtg gccagaccag ggaacctgcg caacaaagca ctgggagcag      180

gccgtgctga tccccctgga ctctgtgagc gaggagaccg ccaaggtgct gaatttcctg      240

cgggtgaaga tccaggccag aaagggagag accgcaaggc agatg                      285


<210>  274
<211>  468
<212>  DNA
<213>  Epsilonretrovirus Walleye dermal sarcoma virus

<400>  274
accgcacaca caatcaagaa gctgatcgtg ggcacaatcg ataagaacaa gcagcagacc       60

gagatcctgc agaagacaga cgagagcgat gaggagatgg acaccacaaa taccatgctg      120

tttatcgccc gcaacaagag ggagaggatc gcacagcagc agcaggcaga tctggcagca      180

cagcagcagg tgctgctgct gcagagggag cagcagaggg agcagagaga gaaggatatc      240

aagaagcggg acgagaagaa gaagaagctg ctgcccgaca ccacacagaa ggtggagcag      300

accgatatcg gagaggccag ctcctctgac gcctccgccc agaagccaat ctctaccgac      360

aacaatcccg atctgaaggt ggacggcgtg ctgacaagaa gccagcacac cacagtgcct      420

tccaacatca ccatcaagaa ggatggcaca tccgtgcagt accagcac                   468


<210>  275
<211>  618
<212>  DNA
<213>  Epsilonretrovirus Walleye dermal sarcoma virus

<400>  275
cccatcagga actatcctac cggcgagggc aatctgacag cccaggtgcg gaaccctttt       60

agaccactgg agctgcagca gctgaggaag gactgccccg ccctgcctga gggcatccca      120

cagctggccg agtggctgac ccagacaatg gccatctaca attgtgacga ggccgatgtg      180

gagcagctgg ccagagtgat cttcccaacc cctgtgaggc agatcgcagg cgtgatcaac      240

ggacacgcag cagcaaatac cgcagccaag atccagaact acgtgacagc atgcaggcag      300

cactatccag ccgtgtgcga ttggggcacc atccaggcct ttacatacaa gccccctcag      360

accgcccacg agtatgtgaa gcacgccgag atcatcttca agaacaatag cggactggag      420

tggcagcacg caaccgtgcc ttttatcaat atggtggtgc agggcctgcc acccaaggtg      480

acacggtccc tgatgtctgg caacccagat tggagcacca agacaatccc acagatcatc      540

cccctgatgc agcactacct gaatctgcag tccagacagg acgccaagat caagcagacc      600

cctctggtgc tgcagctg                                                    618


<210>  276
<211>  381
<212>  DNA
<213>  Epsilonretrovirus Walleye dermal sarcoma virus

<400>  276
gccatgccag cccagacaat gaacggcaat aagggctacg tgggctccta tcctaccaac       60

gagccatact attctttcca gcagcagcag aggccagcac ccagagcccc tccaggcaac      120

gtgccttcca atacctgctt cttttgtaag cagccaggac actggaaggc agactgccct      180

aataagacaa ggaacctgcg caatatgggc aacatgggaa ggggaggaag aatgggagga      240

ccaccttacc ggagccagcc ttatccagcc tttatccagc caccccagaa tcaccagaac      300

cagtataatg gcaggatgga tcgctctcag ctgcaggcca gcgcccagga gtggctgcca      360

ggaacctacc ctgcacgaga c                                                381


<210>  277
<211>  429
<212>  DNA
<213>  Epsilonretrovirus Walleye dermal sarcoma virus

<400>  277
ccaatcgatt gcccctatga gaagagcggc acaaagacca cacaggacgt gatcaccaca       60

aagaatgccg agatcatggt gaccgtgaac cacacaaaga tcccaatgct ggtggatacc      120

ggcgcctgtc tgacagcaat cggaggagca gcaaccgtgg tgccagacct gaagctgacc      180

aacacagaga tcatcgcagt gggaatctct gccgagcccg tgcctcacgt gctggccaag      240

ccaaccaaga tccagatcga gaacacaaat atcgatatca gcccttggta caatccagac      300

cagaccttcc acatcctggg ccgcgacaca ctgtctaaga tgcgggccat cgtgagcttt      360

gagaagaacg gcgagatgac cgtgctgctg cctccaacat atcacaagca gctgtcctgt      420

cagaccaag                                                              429


<210>  278
<211>  381
<212>  DNA
<213>  Gammaretrovirus feline leukemia virus

<400>  278
atgggccaga caatcacaac ccctctgagc ctgaccctgg accactggag tgaagtgcgg       60

gctagagccc acaaccaggg cgtggaagtc cggaaaaaaa agtggatcac cctgtgcgag      120

gccgagtggg tcatgatgaa cgtgggatgg cctagagagg gtacatttag cctggacaac      180

atcagccagg ttgagaaaaa gattttcgct cctggccctt acggccatcc tgaccaggtg      240

ccttacatca ccacatggcg gagcctggct accgacccac caagctgggt gcggcccttc      300

ctgcctcctc ccaagccccc cacccctctg cctcagcctc tgagccccca gccctctgcc      360

cctctgacca gctctctgta c                                                381


<210>  279
<211>  210
<212>  DNA
<213>  Gammaretrovirus feline leukemia virus

<400>  279
cctgtgctgc ctaagtccga tccccctaaa cctcctgttt tacctcccga ccctagcagc       60

ccactgatcg acctgctgac ggaagaacct cctccttatc ctggcggaca tggcccccca      120

ccttctggcc ctcggacccc aaccgcctcc cctatcgcct ctagactgag agagcggaga      180

gaaaaccccg ccgaagagtc ccaagccctg                                       210


<210>  280
<211>  744
<212>  DNA
<213>  Gammaretrovirus feline leukemia virus

<400>  280
cccctgagag agggccctaa caaccggcct cagtactggc ccttcagcgc cagcgatctg       60

tataactgga agtcccacaa tcctcctttc agccaggatc ctgtggccct gacaaacctg      120

atcgagtcta tcctggtgac tcaccagcca acctgggatg actgccagca gctgctgcag      180

gccctcctga ccggcgaaga gagacagaga gtgctgctgg aggccagaaa gcaggtgcct      240

ggagaggacg gcaggcctac ccagctgcct aatgtgatcg acgagacatt ccccctgacc      300

agaccaaatt gggacttcgc caccccagct ggcagagagc acctgcgcct gtaccggcag      360

cttctgctgg ccggactgag aggcgctgcc agaagaccaa ccaacctggc tcaggtgaag      420

caggtcgtgc agggcaaaga ggagacaccc gccgctttcc tggaacggct gaaggaggcc      480

tacagaatgt acacccctta cgaccccgaa gatccaggac aggccgccag cgtgatcctg      540

agcttcatct accagagcag ccctgacatc agaaacaagc tgcagcggct ggaaggcctg      600

cagggcttca cactgagcga cctgctcaag gaggccgaga agatctacaa caagcgggaa      660

acccctgagg aaagagaaga gagattgtgg cagcggcaag aggagcggga caaaaagcgg      720

cacaaggaaa tgaccaaggt gctg                                             744


<210>  281
<211>  171
<212>  DNA
<213>  Gammaretrovirus feline leukemia virus

<400>  281
gctaccgtgg tggcccagaa cagagataaa gacagagagg aatcgaagct gggcgaccag       60

agaaagatcc cccttggcaa ggaccaatgt gcctactgca aggaaaaagg ccactgggtg      120

agggactgtc ccaagagacc cagaaagaag cccgcaaaca gcacactgct g               171


<210>  282
<211>  375
<212>  DNA
<213>  Gammaretrovirus feline leukemia virus

<400>  282
aacctgggcg atcaggagag ccaaggccag gacccccctc ctgagcctag aatcaccctg       60

aagattggag gccagcctgt gacctttctg gtggacaccg gcgcccaaca ctctgtgctg      120

accagacctg atggccccct cagcgataga accgccctgg tccagggagc tacaggcagc      180

aagaactaca gatggaccac cgacagaagg gtgcagctgg ctactggcaa ggtgacacac      240

agctttctgt acgtgcccga gtgcccttac cccctcctgg gcagagatct gttgacaaag      300

ctgaaggccc aaatccactt caccggagag ggcgctaatg tggtgggccc caagggcctg      360

cctcttcagg tgctg                                                       375


<210>  283
<211>  393
<212>  DNA
<213>  Gammaretrovirus Maloney murine leukemia virus

<400>  283
atgggccaga ccgtgaccac acccctgtcc ctgacactgg gccactggaa ggacgtggag       60

cggatcgccc acaatcagtc tgtggatgtg aagaagcgga gatgggtgac cttctgcagc      120

gccgagtggc ccaccttcaa cgtgggctgg ccaagggacg gcaccttcaa ccgcgatctg      180

atcacacagg tgaagatcaa ggtgtttagc ccaggacctc acggacaccc agaccaggtg      240

ccttatatcg tgacctggga ggccctggcc ttcgatccac ctccatgggt gaagccattt      300

gtgcacccaa agccacctcc accactgcct ccatccgccc cttctctgcc actggagcca      360

cctcggtcca ccccaccaag aagctccctg tat                                   393


<210>  284
<211>  252
<212>  DNA
<213>  Gammaretrovirus Maloney murine leukemia virus

<400>  284
cctgccctga caccatctct gggcgccaag ccaaagccac aggtgctgtc tgacagcgga       60

ggacctctga tcgacctgct gaccgaggat cctccaccct acagagatcc aaggcctcca      120

ccatccgaca gggatggaaa cggaggagag gcaacaccag caggagaggc ccctgaccca      180

tcccccatgg cctctagact gaggggcagg cgcgagcctc cagtggcaga tagcaccaca      240

tcccaggcat tc                                                          252


<210>  285
<211>  789
<212>  DNA
<213>  Gammaretrovirus Maloney murine leukemia virus

<400>  285
ccactgaggg caggaggaaa tggccagctg cagtattggc ccttttctag ctccgacctg       60

tacaactgga agaacaataa cccatccttc tctgaggatc ccggcaagct gaccgccctg      120

atcgagagcg tgctgatcac ccaccagccc acatgggacg attgtcagca gctgctgggc      180

accctgctga caggcgagga gaagcagcgg gtgctgctgg aggcaaggaa ggccgtgaga      240

ggcgacgatg gcagacccac ccagctgcct aatgaggtgg acgcagcatt tccactggag      300

aggccagact gggattatac cacacaggcc ggcaggaacc acctggtgca ctacaggcag      360

ctgctgctgg ccggactgca gaatgcaggc aggtccccta ccaacctggc caaggtgaag      420

ggcatcacac agggccctaa tgagagccca tccgcctttc tggagcgcct gaaggaggcc      480

taccggagat atacccccta cgaccctgag gatccaggcc aggagacaaa cgtgtctatg      540

agcttcatct ggcagtctgc cccagacatc ggaaggaagc tggagcgcct ggaggacctg      600

aagaataaga ccctgggcga tctggtgcgg gaggcagaga agatcttcaa caagagagag      660

acacctgagg agagggagga gcggatcagg agggagaccg aggagaagga ggagcggaga      720

aggacagagg acgagcagaa ggagaaggag cgggatcgcc ggagacacag agagatgagc      780

aagctgctg                                                              789


<210>  286
<211>  180
<212>  DNA
<213>  Gammaretrovirus Maloney murine leukemia virus

<400>  286
gccaccgtgg tgtccggaca gaagcaggac aggcagggag gagagaggcg ccggtctcag       60

ctggaccgcg atcagtgcgc ctactgtaag gagaagggcc actgggccaa ggattgcccc      120

aagaagccta gaggcccaag gggccctagg ccacagacca gcctgctgac actggacgat      180


<210>  287
<211>  378
<212>  DNA
<213>  Gammaretrovirus Maloney murine leukemia virus

<400>  287
acactggacg atcaaggagg acagggacag gagccacctc cagagcccag aatcaccctg       60

aaggtcggcg gccagcctgt gacctttctg gtggacacag gcgcccagca cagcgtgctg      120

acccagaatc ccggccctct gtctgataag agcgcctggg tgcagggagc aacaggcggc      180

aagcggtaca gatggaccac agaccggaag gtgcacctgg ccaccggcaa ggtgacacac      240

agctttctgc acgtgcccga ctgtccatac cccctgctgg gcagagatct gctgaccaag      300

ctgaaggcac agatccactt cgagggatcc ggagcacagg tcatgggacc aatgggacag      360

cctctgcagg tgctgaca                                                    378


<210>  288
<211>  459
<212>  DNA
<213>  Lentivirus Caprine Arthritis Encephalitis Virus

<400>  288
atggtgtctc tggacaggga tatggcaagg caggtgagcg gaggcaagag ggattaccca       60

gagctggaga agtgcatcaa gcacgcctgt aagatcaagg tgcggctgag aggagagcac      120

ctgaccgagg gcaactgcct gtggtgtctg aagacactgg actatatgtt cgaggatcac      180

aaggaggagc cctggaccaa ggtgaagttt agaacaatct ggcagaaggt gaagaacctg      240

acccctgagg agagcaataa gaaggacttc atgtccctgc aggccacact ggccggcctg      300

atgtgctgtc agatgggcat gaggccagag accctgcagg acgccatggc cacagtgatc      360

atgaaggatg gcctgctgga gcaggaggag aagaaggagg ataagcgcga gaaggaggag      420

agcgtgtttc caatcgtggt gcaggcagca ggaggccgg                             459


<210>  289
<211>  636
<212>  DNA
<213>  Lentivirus Caprine Arthritis Encephalitis Virus

<400>  289
tcctggaagg ccgtggactc tgtgatgttc cagcagctgc agaccgtggc aatgcagcac       60

ggactggtga gcgaggattt tgagagacag ctggcctact atgccaccac atggacatcc      120

aaggacatcc tggaggtgct ggccatgatg cccggcaaca gagcccagaa ggagctgatc      180

cagggcaagc tgaatgagga ggccgagagg tggcggagaa acaatccacc tccaccagca      240

ggaggaggac tgaccgtgga tcagatcatg ggagtgggac agacaaacca ggcagcagca      300

caggcaaata tggaccaggc cagacagatc tgcctgcagt gggtcatcaa cgcactgagg      360

gccgtgagac acatggcaca caggcccggc aaccctatgc tggtgaagca gaagaccaat      420

gagccttacg aggacttcgc cgccagactg ctggaggcca tcgatgccga gccagtgaca      480

cagcccatca aggactacct gaagctgacc ctgagctata caaatgcctc cgccgactgc      540

cagaagcaga tggatagaac cctgggacag agggtgcagc aggcctccgt ggaggagaag      600

atgcaggcct gtagggatgt gggctctgag ggcttt                                636


<210>  290
<211>  249
<212>  DNA
<213>  Lentivirus Caprine Arthritis Encephalitis Virus

<400>  290
aagatgcagc tgctggccca ggccctgagg cctggcaagg gcaagggaaa cggacagcca       60

cagcggtgct acaattgtgg caagccagga caccaggcaa ggcagtgcag gcagggcatc      120

atatgtcaca actgtggaaa gagaggacat atgcaaaaag aatgcagagg aaagagagac      180

ataaggggaa aacagcaggg aaacgggagg agggggatac gtgtggtgcc gtccgctcct      240

cctatggaa                                                              249


<210>  291
<211>  477
<212>  DNA
<213>  Lentivirus Caprine Arthritis Encephalitis Virus

<400>  291
atgtcacaac tgtggaaaga gaggacatat gcaaaaagaa tgcagaggaa agagagacat       60

aaggggaaaa cagcagggaa acgggaggag ggggatacgt gtggtgccgt ccgctcctcc      120

tatggaataa caagcgcccc tccaatggtg caggtgcgga ttggatctca gcagcgcaac      180

ctgctgttcg acaccggcgc cgatagaacc atcgtccggt ggcacgaggg ctccggcaac      240

cccgccggca gaatcaaact gcaaggcatc ggcggaatcg tggaaggcga gaagtggaac      300

aacgtggagc tggaatacaa gggcgagaca agaaagggca ccatcgtggt gctgcctcag      360

agccctgtgg aggtgctggg acgggacaac atggcccggt tcggcatcaa gatcatcatg      420

gctaatctgg aggaaaaaag aatccccatc accaaggtga agttgaaaga gggatgt         477


<210>  292
<211>  39
<212>  DNA
<213>  Lentivirus Caprine Arthritis Encephalitis Virus

<400>  292
ggtgccgcag gaggccggtc ctggaaggcc ggcggcagc                              39


<210>  293
<211>  372
<212>  DNA
<213>  Lentivirus equine infectious anemia virus

<400>  293
atgggcgatc ctctgacatg gagcaaggcc ctgaagaagc tggagaaggt gaccgtgcag       60

ggcagccaga agctgaccac aggcaactgc aattgggccc tgtccctggt ggacctgttc      120

cacgatacaa actttgtgaa ggagaaggat tggcagctgc gcgacgtgat cccactgctg      180

gaggacgtga cccagacact gtctggccag gagcgggagg ccttcgagag aacctggtgg      240

gccatcagcg ccgtgaagat gggcctgcag atcaacaatg tggtggatgg caaggcctct      300

tttcagctgc tgagggccaa gtacgagaag aagacagcca acaagaagca gtctgagcct      360

agcgaggagt at                                                          372


<210>  294
<211>  690
<212>  DNA
<213>  Lentivirus equine infectious anemia virus

<400>  294
ccaatcatga tcgacggcgc cggcaaccgg aatttcagac cactgacccc cagaggctac       60

accacatggg tgaacacaat ccagaccaac ggcctgctga atgaggcctc ccagaatctg      120

ttcggcatcc tgagcgtgga ttgtacctcc gaggagatga atgcctttct ggacgtggtg      180

ccaggacagg caggacagaa gcagatcctg ctggacgcca tcgataagat cgccgacgat      240

tgggataacc ggcacccact gcccaatgca cctctggtgg caccacctca gggacctatc      300

ccaatgacag ccaggtttat caggggactg ggagtgccac gggagagaca gatggagccc      360

gccttcgacc agtttaggca gacctaccgc cagtggatca tcgaggccat gagcgagggc      420

atcaaagtga tgatcggcaa gccaaaggca cagaacatca ggcagggagc caaggagccc      480

tatcctgagt tcgtggatag actgctgtcc cagatcaagt ctgagggcca ccctcaggag      540

atctccaagt ttctgaccga cacactgacc atccagaacg ccaatgagga gtgccggaat      600

gccatgcggc acctgagacc agaggatacc ctggaggaga agatgtacgc ctgtagagac      660

atcggcacca caaagcagaa gatgatgctg                                       690


<210>  295
<211>  453
<212>  DNA
<213>  Lentivirus equine infectious anemia virus

<400>  295
ctggccaagg ccctgcagac aggcctggcc ggaccattca agggaggcgc cctgaagggc       60

ggccccctga aggccgccca gacctgctat aactgtggca agccaggaca cctgagctcc      120

cagtgcaggg caccaaaggt gtgcttcaag tgtaagcagc ctggccactt ttctaagcaa      180

tgcagaagtg ttccaaaaaa cgggaagcaa ggggctcaag ggaggcccca gaaacaaact      240

ttcccgatac aacagaagag tcagcacaac aaatctgttg tacaagagac tcctcagact      300

caaaatctgt acccagatct gagcgaaata aaaaaggaat acaatgtcaa ggagaaggat      360

caagtagagg atctcaacct ggacagtttg tgggagtaaa catataacct ggagaagcgc      420

cccaccacaa tcgtgctgat caacgacacc cct                                   453


<210>  296
<211>  243
<212>  DNA
<213>  Lentivirus equine infectious anemia virus

<400>  296
ctgaacgtgc tgctggacac aggagctgat acatctgtgc tcaccaccgc ccactacaac       60

cggctgaagt acagaggcag aaagtaccag ggcaccggca tcatcggcgt gggcggaaat      120

gtggaaacct tcagcacccc agtgaccatt aagaaaaagg gccggcacat caaaaccaga      180

atgctggtcg ccgacatccc tgtgacaatc ctgggcagag atatccttca ggacttaggt      240

gca                                                                    243


<210>  297
<211>  39
<212>  DNA
<213>  Lentivirus equine infectious anemia virus

<400>  297
ggtgccagcg aggagtatcc aatcatgatc ggcggcagc                              39


<210>  298
<211>  405
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  298
atgggcgcca ggaacagcgt gctgtccggc aaggaggccg atgagctgga gaaggtgcgg       60

ctgagaccca atggcaagaa gaagtacatg ctgaagcacg tggtgtgggc agcaaacgag      120

ctggaccgct tcggcctggc cgagtctctg ctggataata aggagggctg ccagaagatc      180

ctgagcgtgc tggcccctct ggtgccaacc ggctctgaga acctgaagag cctgtataat      240

acagtgtgcg tgatctggtg tatccacgcc gaggagaagg tgaagcacac cgaggaggcc      300

aagcagatcg tgcagaggca cctggtggtg gagaccggca cagcagatag gatgccagcc      360

accagccgcc caacagcacc accttccgga aggggcggca actac                      405


<210>  299
<211>  690
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  299
cccgtgcagc aagtgggcgg caattatgtg cacctgcccc tgagccctag aaccctgaac       60

gcctgggtga agctggtgga ggagaagaag ttcggagcag aggtggtgcc aggatttcag      120

gccctgtccg agggctgcac accctacgac atcaaccaga tgctgaattg cgtgggagag      180

caccaggcag caatgcagat catccgggag atcatcaacg aggaggcagc agactgggat      240

ctgcagcacc ctcagccagg accactgcct gcaggacagc tgcgggagcc tagaggctct      300

gacatcgccg gcaccacaag caccgtggat gagcagatcc agtggatgta caggcagcag      360

aacccaatcc ccgtgggcaa tatctatcgg agatggatcc agctgggcct gcagaagtgc      420

gtgcggatgt ataacccaac caatatcctg gacgtgaagc agggcccaaa ggagcccttc      480

cagagctacg tggacagatt ctacaagtcc ctgagagccg agcagacaga tcccgccgtg      540

aagaactgga tgacccagac actgctgatc cagaacgcca atcccgattg caagctggtg      600

ctgaagggcc tgggcatgaa tcctaccctg gaggagatgc tgacagcatg tcagggagtg      660

ggaggacctg gacagaaggc aaggctgatg                                       690


<210>  300
<211>  426
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  300
gcagaggccc tgaaggaggc cctgaggcct gaccagctgc catttgccgc cgtgcagcag       60

aagggccaga ggaagaccat caagtgctgg aactgtggca aggagggaca ctctgccaag      120

cagtgcaggg caccaaggcg ccagggatgc tggaagtgtg gcaagacagg ccacgtgatg      180

gccaagtgtc ctgagaggca ggcaggcttc ctgggactgg gaccatgggg caagaagcca      240

agaaattttc ctatggccca gatgcctcag ggactgatcc caaccgcacc accagaggac      300

ccagcagtgg atctgctgaa gaactacatg aagatgggca ggaagcagcg cgagaatagg      360

gagcgccctt ataaggaggt gacagaggac ctgctgcacc tgaactctct ctttggagaa      420

gaccag                                                                 426


<210>  301
<211>  306
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  301
tctctttgga gaagaccagt agttacagcc tacatcgagg aacagcctgt ggaagtgctg       60

ctggatacag gagctgatga cagcatcgtg gccggcattg agctgggacc taactacacc      120

ccaaagatcg tgggcggcat cggcggattc atcaatacca aagagtacaa ggacgtgaag      180

atcaaagtgc tgggcaaggt gatcaagggc accatcatga ccggcgacac acccatcaac      240

atcttcggca gaaacctgct caccgccatg ggcatgtctc tgaacctgcc tatcgccaag      300

gtcgag                                                                 306


<210>  302
<211>  39
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  302
ggtgccggcg gcaactaccc cgtgcagcaa ggcggcagc                              39


<210>  303
<211>  405
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  303
atgggcgcga gaaactccgt cttgtcaggg aaggaagcag atgaattaga aaaagttagg       60

ttacggccca acggaaagaa aaagtatatg ttgaagcatg tagtatgggc agcaaatgaa      120

ttggacagat ttggattagc agaaagcctg ttggataaca aagaaggttg tcaaaaaatt      180

ctttcagttt tagctccatt agttccgaca ggttcagaaa acttaaagag cctttataat      240

actgtctgcg tcatttggtg cattcacgca gaagagaaag tgaaacatac tgaggaagca      300

aaacaaatag tgcagagaca tctagtggtg gaaacaggaa cagcagacag aatgccagca      360

acaagcagac caacagcacc acctagtggc agaggaggaa attac                      405


<210>  304
<211>  690
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  304
ccagtgcagc aagtaggtgg caattatgtc cacctaccct taagtccaag aacattaaat       60

gcttgggtaa aattagtaga agagaaaaaa tttggggcag aggtagtgcc aggatttcaa      120

gcgctatcag aaggctgcac tccctatgat attaatcaaa tgctaaattg tgtaggagaa      180

catcaggcag ccatgcaaat tattagagag attataaatg aagaagctgc cgattgggat      240

ttacaacacc cgcaaccagg tccactacca gcagggcaac ttagagagcc aagaggatca      300

gacattgcag gaactactag tacagtagat gaacaaatcc aatggatgta caggcaacaa      360

aaccccatac cagtaggcaa catttataga aggtggatcc aattagggct gcagaaatgt      420

gtaagaatgt ataacccaac aaacatttta gatgtgaaac aaggaccaaa agagccattt      480

caaagctacg tagatagatt ctacaaaagt ctaagagcag agcaaacaga tcccgcagta      540

aagaattgga tgacccaaac actgctgatt caaaatgcta acccagattg taaactagtg      600

ctcaagggtc tgggcatgaa tcccacttta gaagaaatgc tgacagcctg tcagggagta      660

ggagggccag gacaaaaagc taggttaatg                                       690


<210>  305
<211>  426
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  305
gcagaagcat tgaaagaggc actgaggcca gatcaactcc catttgcagc agtccaacag       60

aaaggacaaa ggaagacaat caagtgttgg aattgtggaa aggagggaca ctctgcaaaa      120

caatgcaggg cccctagaag acagggctgc tggaagtgtg gaaaaacggg tcatgttatg      180

gccaaatgcc ctgaaagaca ggcgggtttt ttagggcttg gcccatgggg aaagaagccc      240

cgcaatttcc ccatggccca gatgcctcag gggctgatac caactgctcc cccagaggat      300

ccagctgtgg atctactgaa gaattacatg aagatgggca gaaagcagag ggagaacaga      360

gagagacctt acaaggaggt gacagaggat ttgctgcacc tcaattctct ctttggagaa      420

gaccag                                                                 426


<210>  306
<211>  288
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  306
tctctttgga gaagaccagt agtcactgcc tacattgaag aacagcccgt agaagtatta       60

ttagatacag gggctgacga ttcaattgta gcagggatag aattgggtcc aaattatacc      120

cctaaaatag taggaggaat aggaggcttc attaacacca aagaatataa agatgtaaaa      180

ataaaagtct taggcaaggt aattaaggga acaattatga cgggagatac cccaattaat      240

atttttggca gaaatttgct aacagctatg ggcatgtctt taaatctc                   288


<210>  307
<211>  57
<212>  DNA
<213>  Lentivirus Simian immunodeficiency virus

<400>  307
cccatagcta aggtggaggg tgccggcggc aactaccccg tgcagcaagg cggcagc          57


<210>  308
<211>  429
<212>  DNA
<213>  Lentivirus visna maedi virus

<400>  308
atggccaagc agggctccaa ggagaagaag ggctaccccg agctgaagga agtgatcaag       60

gcaacctgca agatcagggt gggacctggc aaggagaccc tgacagaggg caactgtctg      120

tgggccctga agacaatcga cttcatcttt gaggatctga agaccgagcc atggaccatc      180

acaaagatgt atacagtgtg ggatcggctg aagggactga ccccagagga gacatccaag      240

agagagttcg cctctctgca ggccaccctg gcctgcatca tgtgctccca gatgggcatg      300

aagcctgaga cagtgcaggc cgccaagggc atcatctcta tgaaggaggg cctgcacgag      360

aataaggagg ccaagggcga gaaggtggag cagctgtacc ctaacctgga gaagcacagg      420

gaggtgtat                                                              429


<210>  309
<211>  660
<212>  DNA
<213>  Lentivirus visna maedi virus

<400>  309
ccaatcgtga atctgcaggc aggaggccgc agctggaagg cagtggagtc cgtggtgttc       60

cagcagctgc agaccgtggc catgcagcac ggcctggtgt ctgaggactt tgagcggcag      120

ctggcctact atgccaccac atggacaagc aaggatatcc tggaggtgct ggccatgatg      180

ccaggcaaca gagcccagaa ggagctgatc cagggcaagc tgaatgagga ggcagagcgg      240

tgggtgagac agaacccacc tggacccaat gtgctgaccg tggaccagat catgggcgtg      300

ggccagacaa accagcaggc cagccaggcc aatatggatc aggccaggca gatctgcctg      360

cagtgggtca tcaccgccct gaggagcgtg cgccacatgt cccacaggcc tggaaaccca      420

atgctggtga agcagaagaa tacagagtcc tacgaggact tcatcgccag gctgctggag      480

gcaatcgacg cagagcccgt gacagatcct atcaagacct acctgaaggt gaccctgtct      540

tatacaaacg ccagcaccga ctgccagaag cagatggata ggaccctggg aacacgcgtg      600

cagcaggcaa ccgtggagga gaagatgcag gcctgtcggg atgtgggctc tgagggcttt      660


<210>  310
<211>  237
<212>  DNA
<213>  Lentivirus visna maedi virus

<400>  310
aagatgcagc tgctggccca ggccctgaga cctcagggca aggcaggaca gaagggagtg       60

aaccagaagt gctacaattg tggcaagcca ggacacctgg caaggcagtg cagacaggga      120

atcatctgcc accactgtgg caagaggggc cacatgcaga aggactgtcg ccagaagaag      180

cagcagggca acaataggag aggaccaagg gtggtgccat ctgccccacc aatgctg         237


<210>  311
<211>  312
<212>  DNA
<213>  Lentivirus visna maedi virus

<400>  311
gtgacagagg cccctcctaa gatcgagatc aaggtgggca caagatggaa gaaactgctg       60

gtcgacaccg gcgctgataa gaccatcgtg accagccacg acatgagcgg catccccaag      120

ggcagaatca tcctgcaggg cattggagga atcatcgagg gcgagaagtg ggagcaggtg      180

cacctgcagt acaaggacaa gatcatccgg ggcaccatcg tggtgctcgc cacatctcca      240

gtggaagtgc tgggaagaga taacatgcgg gaactgggca tcggcctgat catggctaac      300

ctggaagaga aa                                                          312


<210>  312
<211>  39
<212>  DNA
<213>  Lentivirus visna maedi virus

<400>  312
ggtgccaggg aggtgtatcc aatcgtgaat ggcggcagc                              39


<210>  313
<211>  1632
<212>  DNA
<213>  Bovispumavirus bovine foamy virus

<400>  313
atggccctga atgatttcga ccctatcgcc ctccagggct acctgccggc ccctagagtg       60

ctgcaacaca acgacatcat catctgcaga gctacttctg gcccctgggg catcggcgac      120

agatacaacc tgatcaggat ccacctgcaa gaccctgccg gacagcccct tccaatcccc      180

cagtgggagc ctatccctaa ccggaccgcc aacccccgga cacagcccta ccctgtggtg      240

tctgccccaa tggctaccct ggaaaacatc ctgaacaact ttcacatccc ccacggcgtg      300

tccagatacg gccccctgga aggcggagat taccagcctg gcgaacagta cagccaaggc      360

ttctgccctg tgacccaggc cgagattgcc ctgctgaacg gccagcacct ggaagaagag      420

atcacaatcc tgagagagat cacccacaga ctgatgcagg gcgtgcggcc tcctgccgtg      480

cctcagggcc ctgctcctcc tcctcctcca gctcagcctc ctgctcccct gcctgctcca      540

ccaattgggc ctccacctcc cgctgcccct gcccccgccc caggccccat gcctgtgccc      600

cagcatctgc ctattacaca tatcagagcc gtgatcggcg aaacccccgc caacatccgc      660

gaggtgccac tgtggctggc tagagccgtt cccgccctgc agggagtgta ccccgtccag      720

gacgccgtga tgagaagccg caccgtgaac gccctgaccg tgcggcaccc tggactggcc      780

ctggaacctc tggagtgcgg cagctggcaa gagtgtctgg ccgccctgtg gcagagaacc      840

ttcggcgcca ccgccctgca cgccctgggc gataccctgg gtcagatcgc aaacagcgac      900

ggcatcgtga tggctatcga gctgggcctg ctcttttccg atgataactg ggacctggtg      960

tggggaatct gtagaagatt cctgcccggc caggccgtct gcgtggccgt gcaggccaga     1020

ctggatcccc tgcccgacaa cgctacaaga atcgtgatga tcagccacat catccgggac     1080

gtgtacgcca tcctgggcct ggaccctctg ggcagaccca tgcagcagac actgcctaga     1140

cggaacaacc agcctcccag acagcagcca cagagacggc agcagcctag aagaaccggc     1200

aaccaggagg aaagaggcca gcggaaccgg ggccggcaga acgcccagac ccctcggcag     1260

gagggcaaca gactgcagaa cagccagctg cctggccctc gcgactgccc caacaatagc     1320

aaccagcctc ggtaccctct gcggccaaac ccccagcagc cccaaagata cggccaggag     1380

cagaatcgtg gcaacaatcc caacccttac agacaaccta cccctggcaa tggaaatcaa     1440

aacagaaact tcagccgggg gcctgcccca gtcaatgagc agagcagagg cagaggaaga     1500

tctagccagg gtacaaataa caccggctcc tctgctgtgc acagcgtgcg gctgaccagc     1560

gccgcccctc ctataccccc acaagatgcc ggcactccgc ccacttcaag tggaaatcaa     1620

gggcaatcat ct                                                         1632


<210>  314
<211>  438
<212>  DNA
<213>  Bovispumavirus bovine foamy virus

<400>  314
atgccggcac tccgcccact tcaagtggaa atcaagggca atcatcttaa aggctactgg       60

gacagcggcg ccgagatcac atgcgtgccc gctatctaca tcatcgagga acaacctgtt      120

ggcaagaagc tgattacaac catccacaac gagaaggaac atgatgtgta ctacgtggaa      180

atgaaaatcg agaagcggaa ggtgcagtgt gaagtgatcg ccaccgccct ggattacgtg      240

ctggtggccc ctgtggacat cccctggtat aagcctggac ctctggaact gaccatcaag      300

atcgacgtcg agagccagaa gcacaccctg atcacagagt ccaccctctc tccacagggc      360

cagatgagac tgaagaaact gctggaccag taccaggccc tgtggcagtg ctgggagaac      420

caggtgggcc acagaaga                                                    438


<210>  315
<211>  39
<212>  DNA
<213>  Bovispumavirus bovine foamy virus

<400>  315
ggtgcctctg ctgtgcacag cgtgcggctg ggcggcagc                              39


<210>  316
<211>  1929
<212>  DNA
<213>  Prosimiispumavirus Brown greater galago prosimian foamy virus

<400>  316
atgtctcagc cctcggcttc cggttcagct ggcgctggtg gagctcctca gcagccccct       60

ccaccgccac ctcagcccgg cccagcggct ccagtgccac gagcacaaat tggttatggt      120

gacctggacg tacttttatt acaacaggaa tatcatttga tagatccaaa tttacaggta      180

caacacttag acactttatt agttagaatc acaggaggca actggggacc aggtgaccga      240

tttgctcgta ttgaggttct tcttagggac accctaggac cactccaaca acccaggtat      300

aggtatgcag caatgcagca agcagatctc aggaatgaca tcatcctgca tctaaattat      360

caagatgcaa ttataatttt tgatatgata ataccatctg aaggagttca taggcatgga      420

cccatgttcg atggactttg gattcatgga gatgattact ccatgaactt tcagccaatt      480

acagcacatg aactgtatct tttgccacag caagttctca cagaagaagt ggaactgctg      540

acggaagtgt gcaaccgaat ggcagactgg ataagacggc atcgctgtgg aggaggaagt      600

ggaagctcac aacccccgcc gccgcctcca cccgctgtgc ctgtcttgcc ttcagcacct      660

ccggctagca gtttaccctt accaccacaa ggatggggaa tctccccacc agtagccaca      720

tccactccag gagcggcagg acatagctcc agtgccggcc ctaatatttc ccttggtgga      780

acatatgttc ctccaccggt agcaccacca gctccggtga tagggggacc cggaggtccc      840

ggacagttgc cagcaatggt gcaagtcctc cccgctcagc cagtagtaat tcccatcaat      900

gttatccgaa gtgtttgtgg agatactcca tcaaacccac aggatattcc attgtggatg      960

ggaagaatta ttccagccat tgagggtgtg tttcctattg ataatccaaa tctacgaatg     1020

agagttgtga atgccctgct tgccctacat ccgggcttag caataacaga acttaatgcc     1080

cagacttggg gacaagtctt ggctgtgctc catatgcgag ccttgggaca cacagccctc     1140

catcagcttc ctgcactctt ggagactatt gtcaagacag atggcatatt gccagcatat     1200

aatatgggta tggaagtaac tcaacaagac ttttcatacg tatggggaat tttaagaaca     1260

ctacttccgg gacaagcatt tgtcctaagt atgcaaaatg aattagatag attacctgcg     1320

gctcagagac cgggaatgtt tcccggccta ctgcagagga ctctggacat actagggtta     1380

aattctcggg gacaaaatat tcaaaaaacc aatactcagc aacaagctcc aaaaaggggt     1440

cagaaaccga aacctcgact tcctcctgtg cataggcgac ccgcaccatt tacaccacct     1500

gctaccccta gcccgcgaca acaagcttct gcttcccctt cttcgcaggg cgataaccga     1560

agtcctcaac cccaagggcg tggtacttac ggaccgtcca gaggaggagg cagtgggccc     1620

agatataact tcaggccccg agtgcaacca cctgatcgat acggctttgg aaggggacaa     1680

gggggtcgca gttcaatagg tgctcaagat aatcaacagc ctggtcaagg aggacaacgc     1740

actcaacaaa caaaccaaaa ccgaaaccaa ggcaacgcca cgggaggaag aactcaacct     1800

caaaatcgca ctgtgaatac tgtgcgtgtc acacagacta acccccaagg aggaagttca     1860

gtgtcaaacc cagctgtgac aacttctcag aatacaggaa caggaagtgc aactcagagc     1920

tcatcatct                                                             1929


<210>  317
<211>  429
<212>  DNA
<213>  Prosimiispumavirus Brown greater galago prosimian foamy virus

<400>  317
caacttctca gaatacagga acaggaagtg caactcagag ctcatcatct taaaggcttt       60

gtggacacag gcagcagcat cacctgcttc cccaagtaca ccctggtcga ggaagatcct      120

atcggccagt acgacatcag caccatccac ggcacagtgt cccagcctgt gtactacatc      180

aagttcaagg tgaacggcaa gaaagtggaa gccgaggtga ccgagtctcc actggactac      240

gtgatcctgt gtcctagcga cgtgccctgg ctgtctacaa agctggaact gacaattaag      300

ctgcctctgc accagcagca acaggagctg ctgagcaaga ccagagtgaa tcaaaaacag      360

ctgcagaaac tctttatcca gtatgatgac ctgtggcaga agtgggagaa ccaggttgga      420

caccggaag                                                              429


<210>  318
<211>  39
<212>  DNA
<213>  Prosimiispumavirus Brown greater galago prosimian foamy virus

<400>  318
ggtgccagaa cagtgaacac cgtgcgggtg ggcggcagc                              39


<210>  319
<211>  1944
<212>  DNA
<213>  Betacarmovirus Cardamine chlorotic fleck virus

<400>  319
atggcctctg gcagcaacgt ggaggaatac gagctggatg tggaagccct ggtggtcatc       60

ctgcgggaca gaaacatcgg aagaaatccc ctgcacggcg aaatcatcgg cctgagactg      120

accgagggct ggtggggcca gatcgagaga tttcagatgg tgcggctgat cctgcaggac      180

gacgacaacg agcccctgca gagaccccgc tacgaggtga tccccagagc cgtgaacccc      240

cacaccatgt tcatgatcag cggccccctg gctgaactgc agctggcctt ccaggacctg      300

gacctgcccg agggccctct gcggtttggc ccgctggcta acggccacta cgtgcagggg      360

gatccttaca gcagcagcta ccggcccgtg accatggccg aaacagccca gatgaccaga      420

gatgagctgg aagatatcct gaacacccaa agcgagatcg agatccagat gatcaacctg      480

ctggaacttt atgaggtgga aaccagagcc ctgagaagac agctggccga gagaagcagc      540

atcggccagg gaggagtgag ccccggcgct ccaaggccga gacctccagt tagcagcttc      600

agcggcctgc ctagcctgcc ttctatcccc ggcatccacc ccagagcccc ttcccctcct      660

cgcgctacaa gcacccctgg taacatcccc tggtccctgg gagatgacag cccacctagc      720

tcgtcttttc ctggccctag tcagcctaga gtgtctttcc accctggcaa tcctttcgtg      780

gaggacgagg gacatagacc tagatcccag agccgggaaa gacggagaaa caatcctcct      840

gcccctatcc ctagcgcccc tccaatgatc caatacgtgc ccgtgcctcc tccacctcct      900

gtcggaaccg tgatacctat ccaacacatc cggtccgtga ccggcgagcc tccaaagaac      960

ccccgagaaa tccccatctg gctgggccgg aatgcccctg ctatcgacgg cgttttcccc     1020

gtgacgaccc cagacctgcg gtgcagaatc atcaacgcca ttctgggagg caacctgggc     1080

ctgagcctga cacctgccga ctgtgtgacc tgggactctg ccgtgggcac cctgttcgtg     1140

cggacacacg gacagttccc tatgcaccag ctgggcacag tgatccaggg catcgtgaac     1200

caggagggcg tggctaccgc ttatacactg ggcatgatgc tgagcggcca gaattacccc     1260

ctcgtgagcg gcatcatcag aggctacctg cccggccagg ccgtggtgac cgcccttcag     1320

cagcgcctgg accaggaggt ggatgaccag gccagggctg aaaccttcat ccagcacctg     1380

aacgctgtgt acgagatcct gggcctcaac gccagaggac aatctatcag agccagcgtg     1440

acaccgcaac ctcggccaag ccggggccgc ggcagaggcc agtctacacc tagaccttcc     1500

cagggccctg tgagttcagg acggggcaga cagcggcctg ccagcggcca gtacgacaga     1560

ggcagcaaca accagaacca agaccagggt aacaccagcc agggcggcta caacctgaga     1620

ccaagaacct accagcctca gagatacggc ggcggaagag gtcggagatg gaacgagaac     1680

accaacagcc aggagagcag acccagcgat cagggctccc agacaccccg gcctaaccaa     1740

gctggcagcg gcgtcagagg caaccagagc cagaccccta gacccgccgc cggcagagga     1800

ggcagaggca atcagaatag aaaccagcgg tctagcggag ccggcgatag cagagccgtc     1860

aacacagtga cccagagtgc cacgtcctcc acagatgaat cctcttcagc tgttgcaacc     1920

gcttccagcg gagatcaaag gaac                                            1944


<210>  320
<211>  447
<212>  DNA
<213>  Betacarmovirus Cardamine chlorotic fleck virus

<400>  320
atgaatcctc ttcagctgtt gcaaccgctt ccagcggaga tcaaaggaac taaactgtta       60

gcccattggg acagcggcgc caccattaca tgcgtgcccg agtccttcct ggaagatgag      120

cagcctatca aacagaccct gatcaagaca atccacggcg agaagcagca gaaagtgtac      180

tacctgacct ttaagatcaa gggaagaaag gtggaagctg aagtgatcgc cagcccttac      240

gagtacatcc tgctgtctcc aacagacgtg ccttggctga cacagcaacc tctgcagctg      300

accatcctgg tccccctgca ggagtatcag gatagaatcc tcaacaagac cgccctgcct      360

gaggaacaga agcaaagact gaagaccctg ttcgccaagt acgacaccct gtggcagcac      420

tgggagaacc aggtgggcca ccggcgg                                          447


<210>  321
<211>  39
<212>  DNA
<213>  Betacarmovirus Cardamine chlorotic fleck virus

<400>  321
ggtgccagag ccgtcaacac agtgacccag ggcggcagc                              39


<210>  322
<211>  1677
<212>  DNA
<213>  Equispumavirus equine foamy virus

<400>  322
atggcccaga acgagacatt tgatcctgtg gccctgcagg gctactaccc tgctggcggc       60

atcctggccg acaatgacat tatcaacatc agattcacca gcggacagtg gggcatcggc      120

gatagatggc tgcaggtgcg gctgagactg gtggacccta atactggaca gcctctggct      180

cagcctgagt acgaggacac aggcctgcct gccgaaaaca ggggtatcgt ggtggccgtg      240

tcccacaacg ccgccagaaa tatcttcaac aacgtgcagc cagctggtgg ccccaacaga      300

cacggccctc tgcacgacgg ccaatttcaa gtgggcgacg atcccagcga gcacttcgtg      360

cctattgagg aaaacctgat cccccaggag atcgtgaacc tgggagcagc tagaagagaa      420

gtgcggctgc tgagagaaat gtgcgtgcgg ctgctgcacg tgagaagaca gatgatgggc      480

atgggcatgc ctggcgctat ccagcctcaa ccgccagtgg gccccctgcc cgcccctgcc      540

cagcccccta tccctggccc acctgtgcct ccccccgtgc ctccccccgc ccctccagcc      600

cctgtcaacc cccctgtccc tccagtgcag cctatccacc acctgcctat tacccacatc      660

cgggccgtga tcggcgagac acctgcccag atcagagatg tgcccctgtg gctggcccag      720

tccatccctg ccctgaccgg cgtttatcct gccatggacg ccggaacact gacaagactg      780

gtgaacgcga tcaccgccag acaccccgga ctcgctcttg gcatgaacga ggccggctcc      840

tggcacgagg ccgttcatct gatctggcag aggaccttcg gcgctacagc cctccatgcc      900

ttgtctgatg tgctgaaggg catcgcccag cggaacggcg tggtgatggc cctggaaatg      960

ggcctgatgt tcaccaacga cgactgggac ctgacctggt ctgtgatccg gagatgtctg     1020

cctggacaag ccagcgttgt gaccatccag gcccggctgg atgccctgcc aaacaaccag     1080

gccaggatca tccaggccgg ctttatcatc agagaggtgt acgaggtgct gggcctggac     1140

ccactgggcc ggccactgaa cttccctgga ggcctgaccc agcgagacac cgccgtgccc     1200

gtgaccagag gccggggccg cggaagaacc ggccctagaa gaggccctgt gctgcctgtc     1260

agcagcaacc agcgccggca agaaaccgca ggcggcaacc agcctcagac ccaaccccag     1320

cagcagaaca cattcagcaa tcagacaaat cagagaggaa accagcggca gtggcaaaat     1380

agaggaaccg acagccagag acggtacttc ttcagaccca gaccaagcca gcctcagcgg     1440

tacggcagca accagggccc tgacaaccct aatccctaca gaggaagaga tagcaccaat     1500

caaagcggcc aggagcggca gctgcctcag cagcaacagg gctctagaag gggccctggc     1560

agaaacacaa acagcggcaa caacaccgtg cacaccgtgc ggcaagtgga atcttctcag     1620

ctacaacaaa atgcaagccc tacagcctct ccaagtacaa atcaagggca acagcct        1677


<210>  323
<211>  438
<212>  DNA
<213>  Equispumavirus equine foamy virus

<400>  323
atgcaagccc tacagcctct ccaagtacaa atcaagggca acagccttaa gggattttat       60

gataccggcg ccgagatcac ctgcgtgcca gccatcttcc tgatcgagga agagcctatc      120

ggcgagcgga ccatccaaac aatccacggc atcacaaagg aaaaggtgta ctacctgacc      180

tttaagatcc agggcagaaa gctggccgct gaagtgattg gaacccagct ggactacgtg      240

atcatcgccc ctagcgacat cccctggtac aagaaatacg agctggaact gacaattaaa      300

atcgacatcc agaaacagca ggagcagctg ctgcacacca ccaacctctc tagcgaggga      360

aagaagtacc tgaaggacct gttcatcaag tatgataatc tgtggcagaa gtgggaaaac      420

caggtcggcc acagaaga                                                    438


<210>  324
<211>  48
<212>  DNA
<213>  Equispumavirus equine foamy virus

<400>  324
ggtgccaaca ccgtgcacac cgtgcggcaa gtggaatctg gcggcagc                    48


<210>  325
<211>  1542
<212>  DNA
<213>  Felispumavirus feline foamy virus

<400>  325
atggcccggg aactgaaccc cctgcagctg caacagctgt acatcaacaa tggcctgcag       60

cccaatcccg gccacggaga tatcatcgca gttagattca caggcggccc ttggggcccc      120

ggagatagat gggccagagt gaccatccgg ctgcaggaca acaccggcca gcctctgcaa      180

gtgcccggat acgacctgga gcctggcatc atcaatctgc gggaagatat cctgatcgcc      240

ggcccataca acctcatcag aacagctttt ctggacctgg aacctgccag aggaccagag      300

cggcacggcc cgttcggcga cggcagactg cagcctggcg atggactgag cgagggattt      360

cagcctatca ccgacgagga aatccaggct gaagtgggca ccatcggcgc cgcccgtaac      420

gagatccggc tgctgagaga agccttgcag agactccagg ctggcggtgt tggacggcct      480

atccctgggg ccgtgctgca gcctcaacct gtgatcggac ctgtgatccc catcaaccac      540

ctgagaagcg tgattggcaa cacacctcct aaccccagag atgtggccct gtggttgggc      600

agatctacag ccgctatcga gggcgtgttc cccatcgtgg accaggtgac ccggatgaga      660

gtggtgaacg ccctggtcgc ctctcatcct ggcctgaccc tgacagagaa cgaggccggc      720

agctggaacg ccgccatcag cgccctgtgg cggaaggccc acggcgctgc tgctcagcac      780

gagctggccg gagtgctgag cgacatcaac aagaaggaag gcatccagac agccttcaac      840

ctgggcatgc agttcaccga tggcaattgg tccctggtgt ggggaatcat caggaccctg      900

ctgcccggcc aggccctggt cacaaacgcc cagagccagt tcgacctgat gggcgacgac      960

attcagcggg ccgagaactt ccccagagtg attaacaacc tgtacaccat gctgggcctg     1020

aacatccacg gccagagcat cagacctaga gtgcagaccc agcctctgca gaccagacct     1080

cggaaccctg gcagaagcca gcagggtcag ctgaatcagc ctcggcctca gaacagagcc     1140

aaccagtcct acagaccccc tcggcagcag caacaacaca gcgacgtgcc tgagcagagg     1200

gaccagagag gcccatctca accgcctaga ggctctggcg gaggctataa cttcagaaga     1260

aatccccagc agcctcagcg gtacggccaa ggcccccccg gcccaaaccc ttacagacgg     1320

ttcggcgacg gcggcaatcc ccagcagcaa ggcccgcctc caaatagagg ccctgatcag     1380

ggacctagac caggcggcaa ccctcgcggc ggcggcaggg ggcagggccc ccggaacggc     1440

ggaggcagcg ccgccgccgt gcacaccgtg aaagccagcg aaaacgaaac taaaaatgga     1500

tctgctgaag ccgttgacgg tggaaagaaa gggggtaaag at                        1542


<210>  326
<211>  438
<212>  DNA
<213>  Felispumavirus feline foamy virus

<400>  326
atggatctgc tgaagccgtt gacggtggaa agaaaggggg taaagattaa aggttactgg       60

gattctcagg ccgacatcac ctgcgtgcca aaggacctgc tgcagggcga ggaacccgtg      120

cggcagcaga atgtgaccac catccacggc acccaggagg gcgatgtcta ctacgtgaac      180

ctgaagatcg acggcagaag aatcaacacc gaggtgatcg gcacaacact ggactatgct      240

atcatcaccc ctggcgacgt gccttggatc ctgaagaaac ctctggaact gacaattaag      300

ctggatctgg aagagcaaca aggaaccctg ctcaacaaca gcatcctgag caagaagggc      360

aaggaagagc tgaaacagct gttcgagaag tactccgccc tgtggcagag ctgggagaac      420

caggtgggac acagacgg                                                    438


<210>  327
<211>  39
<212>  DNA
<213>  Felispumavirus feline foamy virus

<400>  327
ggtgccgccg ccgtgcacac cgtgaaagcc ggcggcagc                              39


<210>  328
<211>  1941
<212>  DNA
<213>  Simiispumavirus Rhesus macaque simian foamy virus

<400>  328
atggccgctg tggaaggcga tctggacgtg caagccctga ccgatctgtt caacaacctg       60

ggcatcaacc gggacccccg gcaccgggaa gtgatcgccc tgcggatgac aggcggctgg      120

tggggccctg ccaccagata caacctgatc accgtgctgc tgcaggatga tcagggtcag      180

cctcttcagc agccccggtg gcgggccgag ggccgggccg ccaaccccgc tgtgatgctg      240

accctggaag ccccatggca ggacctgcgg atggcctttg acaacgtcga cctggccgac      300

gacacactgc ggtttggccc tctggctaac ggcaattaca tccccggcga cgagtacagc      360

ctggagttca tccctcccgc catgcaagag atcgcccaaa tgcagagaga tgagctggaa      420

aacgtgctgg acattgtggg ccagatcaca atgcagatga gcgacctgat cggaatgcag      480

gacgcccaga tccggggcct ggagggccaa atcagaggcc tgagaggcaa tctgcccgtg      540

gccggaacac caccacctcc tcctccaagc ctggacctgc agcctgccgc cgccagcagc      600

ccttacgtgg cccctgcgtc tagcgctcct gccgcacccg tggcctctgc tgatctgggc      660

tggttcgccg ggggaccttc cccaggctct gtggaccctc ggctggcccg ggtcgcctac      720

aaccccttcc tgcccggacc tagcgacggc agcggcgtgg ccccggtgca gccctccgcc      780

cctcctgccg ccagccctct gctgcccctg ccacctgctc agcctgtgca gccagtgatc      840

cagtacgtgc accctcctcc tatgaaccct gcccagcaga ttattcctat ccagcacatc      900

agagccgtga ccggcaacgc ccccaccaac cctagagaga tccctatgtg gatcggcaga      960

aacgccagcg ccatcgaggg cgtgttcccc atgaccaccc ctgatctgag gtgtcgggtg     1020

atcaacgccc tgctcggcgg caacctgggc ctgaacctgg aaccacagca ctgcgtgacc     1080

tgggccagcg caatcgccac cctgtacgtt agaacccacg gcagctaccc catccaccag     1140

ctggctgaag tgctgagagg cgtggctaat agcgagggag ttgctgccgc ttatcagctg     1200

ggcatgatgc tgacaaaccg ggattacaac ctgatctggg ggatcatccg ccctctgctg     1260

cccggccagg ccgtcgtgac cgccatgcag catagactgg atcaggagat caacgacgcc     1320

gccagagtgg cctctttcat caatcacctg aacggcgtgt acgagctgct gggcttgaac     1380

gccagaggcc agagcctgag aatccctgcc tctggcggac agaccacggc cggaaccagc     1440

gccggcagag gcacaagagg aagacgcagc cagcaaggca cacctggcag acagagcagc     1500

ggccagagcc agcagcaggg aagaagaagc agccagggcc agagcagaca gtcagactcc     1560

agcgaccaga acgtgcagag acaatcccag ggcggcaacg gacggggagg ctataatctg     1620

agacccagga cctaccagcc ccagagatac ggcggaggca gaggcagaag gtggaacgac     1680

cagcctgcca gatcagacaa ccagcagcgg tcccaatctc aacagcctca gtccgaggct     1740

agaggcgagc agagcagaac cagcggagcc ggcagaggac agggcggccg ggggaatcaa     1800

aacagaaacc agagaagcgc cggtggcaat gccgacagaa cagtgaacac cgtgacaacc     1860

gccagcgctt ctacaagcgc ctcaggtcaa gatggatcct ctccagctcc tccagcctct     1920

ggaagcggaa atcaagggaa c                                               1941


<210>  329
<211>  447
<212>  DNA
<213>  Simiispumavirus Rhesus macaque simian foamy virus

<400>  329
atggatcctc tccagctcct ccagcctctg gaagcggaaa tcaagggaac taaattaaaa       60

gcccactggg acagcggagc caccattaca tgcatccccg aggcttttct ggaagatgag      120

cagcctatcc aaacaatgct gatcaagacc atccacggcg agaagcagca gaacgtgtac      180

tacctgacat tcaagatcca gggcagaaag gtggaagccg aggtgctggc ctctccttat      240

gactacatcc tgctcaatcc ttctgatgtg ccatggctga tgaaaaagcc tctgcaactg      300

accgtgctgg tccccctgca ggactaccag gagcggctgc tgaaacagac caccctgcct      360

aaggaacaga aggaccagct ggaaaagctg ttcctgaagt acgacgccct gtggcagcac      420

tgggagaacc aggtgggcca cagaaga                                          447


<210>  330
<211>  39
<212>  DNA
<213>  Simiispumavirus Rhesus macaque simian foamy virus

<400>  330
ggtgccagaa cagtgaacac cgtgacaacc ggcggcagc                              39


<210>  331
<211>  1941
<212>  DNA
<213>  Spumavirus Simian foamy virus

<400>  331
atggccgcca tcgagggcga tctggacgtg caggccctgg ctaacctgtt caacgacctg       60

ggcatcaaca gaaaccccag acacagagag gtgattgccc tgagaatgac cggcggctgg      120

tggggccccg ctaccagata taatctggtg agcctgctgc tgcaggacga ccagggccag      180

cctctgccac agcccagatg gcgggctgaa ggcagagccg caaaccccgc cgtgatgttc      240

accctggaag ccccctggca ggatctgaga ctggcctttg acaatatcga cgtgggcgag      300

ggcacactga gattcggccc acttgctaac ggcaactaca tccccggcga cgagttcagc      360

ctggagttcc tgcctcctgc catgcaggag atcacacaga tgcagagaga tgagctggag      420

gaagtgctgg atgtggtggg ccagatcaca atgcagatga acgacctgat cggcatgcag      480

gacgcccaga tccggggact ggaaggacaa ctgagaggac tgagaggcaa tctgccagtg      540

gccggcacac ctccacctcc tccacccagc ctggacctgc agcctgctgc cgccagcagc      600

ccctacgtgg cccctgcacc ttccgctcct gctgcctctg ccgccgcagc cgacctggga      660

tggttcgccg gaggccctgg ccctggatct ctggaccccc gcctcgcccg ggtggcctac      720

aacccctttc tgcctggccc tagcgacggc agcggtgccg ctcccgccca gcctagcgct      780

cctccggtgg cctctcctct gccttctctg ctgcctgccc agcccatgca acctgtgatc      840

cagtacgtgc accccccacc tatcaatcct gctcaacagg tgatccctat tcagcatatc      900

agagccgtga ccggcaacgc ccctagcaac ccaagagaaa tccctatgtg gatcggaaga      960

aacgccagcg ccatcgaggg cgtgttcccc atccctacat ctgacatccg ttctagagtg     1020

atcaacgccc tgctgggtag acagctgggc ctgaacctgg atcctcagca ctgcatcacc     1080

tgggccagcg caatcgccac tctgtacgtg cgcacccacg gcagctaccc tctgcaccag     1140

ctggccgagg ttctgcggag agtctccaac agcgaaggcg cggccgccgc ctggcagctg     1200

ggcatgatgc tgaccaacca ggactacaac ctcgtgtggg gaatggtcag acccctgctg     1260

cccggccagg ctgtggtcac cgccatgcag caccggctgg atcaggaggt ttctgatgcc     1320

gccagaatcg tgtccttcgt gaaccacctg aacgccgtgt acgagctgct gggcctgaat     1380

gccagaggcc agaacctcag ggtctccacc ggcggccaga ccaccgctag aacaagcgcc     1440

ggcagaggcg ccagaggcag acggtcccag caggggaccc ctggcaggca gtctagcgga     1500

caggcccctc ctcaaggccg gagaagcagc cagggccagc agcctaggca gtctgagagc     1560

ggcgaccaga acaaccagcg gcagctccag ggaggaaaca accggggcgg ctataacctg     1620

cggcctcgga cataccagcc tcagcggtac gggggaggcc ggggccggag atggaacgat     1680

cagaccgcca gagccgataa ccagcagcgg agccaatccc aacaacctca gagcgaggcc     1740

cggggcgagc agagcagaac cagcggcgcc ggcagagaac agggcggcag aggcaatcaa     1800

aatcggaatc aaagatctgc cggagaaaac accgacagat ccgtgaacac cgtgacagcc     1860

accagcgcca gcatcagcgc ctcaggtcaa aatggatcct ctacaactcc tccagcctct     1920

ggaagcggaa atcaagggaa c                                               1941


<210>  332
<211>  447
<212>  DNA
<213>  Spumavirus Simian foamy virus

<400>  332
atggatcctc tacaactcct ccagcctctg gaagcggaaa tcaagggaac taaattaaaa       60

gcccactggg atagcggagc tacaatcacc tgcgtgcccg aggcctttct ggaagatgag      120

agacctatcc agaccatgct gatcaagacc atccacggcg agaagcagca ggacgtctac      180

tacctgacct tcaaggtgca gggcagaaag gtggaagccg aggtgctggc ctctccttat      240

gactacatcc tgctcaaccc cagcgacgtg ccttggctga tgaaaaagcc tctgcagctg      300

acagtgctgg tgccactgca cgagtaccag gagcggctgc tgcaacaaac cgccctgcct      360

aaggaacaga aagagctgct gcagaagctg ttcctgaagt acgacgccct gtggcagcat      420

tgggaaaacc aggtgggcca ccggaga                                          447


<210>  333
<211>  39
<212>  DNA
<213>  Spumavirus Simian foamy virus

<400>  333
ggtgccagat ccgtgaacac cgtgacagcc ggcggcagc                              39


<210>  334
<211>  396
<212>  DNA
<213>  Lentivirus human immunodeficiency virus

<400>  334
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattac                                396


<210>  335
<211>  693
<212>  DNA
<213>  Lentivirus human immunodeficiency virus

<400>  335
cctatagtgc agaacatcca ggggcaaatg gtacatcagg ccatatcacc tagaacttta       60

aatgcatggg taaaagtagt agaagagaag gctttcagcc cagaagtgat acccatgttt      120

tcagcattat cagaaggagc caccccacaa gatttaaaca ccatgctaaa cacagtgggg      180

ggacatcaag cagccatgca aatgttaaaa gagaccatca atgaggaagc tgcagaatgg      240

gatagagtgc atccagtgca tgcagggcct attgcaccag gccagatgag agaaccaagg      300

ggaagtgaca tagcaggaac tactagtacc cttcaggaac aaataggatg gatgacacat      360

aatccaccta tcccagtagg agaaatctat aaaagatgga taatcctggg attaaataaa      420

atagtaagaa tgtatagccc taccagcatt ctggacataa gacaaggacc aaaggaaccc      480

tttagagact atgtagaccg attctataaa actctaagag ccgagcaagc ttcacaagag      540

gtaaaaaatt ggatgacaga aaccttgttg gtccaaaatg cgaacccaga ttgtaagact      600

attttaaaag cattgggacc aggagcgaca ctagaagaaa tgatgacagc atgtcaggga      660

gtggggggac ccggccataa agcaagagtt ttg                                   693


<210>  336
<211>  42
<212>  DNA
<213>  Lentivirus human immunodeficiency virus

<400>  336
gctgaagcaa tgagccaagt aacaaatcca gctaccataa tg                          42


<210>  337
<211>  164
<212>  DNA
<213>  Lentivirus human immunodeficiency virus

<400>  337
atacagaaag gcaattttag gaaccaaaga aagactgtta agtgtttcaa ttgtggcaaa       60

gaagggcaca tagccaaaaa ttgcagggcc cctaggaaaa agggctgttg gaaatgtgga      120

aaggaaggac accaaatgaa agattgtact gagagacagg ctaa                       164


<210>  338
<211>  204
<212>  DNA
<213>  Lentivirus human immunodeficiency virus

<400>  338
tttttaggga agatctggcc ttcccacaag ggaaggccag ggaattttct tcagagcaga       60

ccagagccaa cagccccacc agaagagagc ttcaggtttg gggaagagac aacaactccc      120

tctcagaagc aggagccgat agacaaggaa ctgtatcctt tagcttccct cagatcactc      180

tttggcagcg acccctcgtc acaa                                             204


<210>  339
<211>  297
<212>  DNA
<213>  Lentivirus human immunodeficiency virus

<400>  339
cctcagatca ctctttggca gcgacccctc gtcacaataa agataggggg gcaattaaag       60

gaagctctat tagatacagg agcagatgat acagtattag aagaaatgaa tttgccagga      120

agatggaaac caaaaatgat agggggaatt ggaggtttta tcaaagtaag acagtatgat      180

cagatactca tagaaatctg cggacataaa gctataggta cagtattagt aggacctaca      240

cctgtcaaca taattggaag aaatctgttg actcagattg gctgcacttt aaatttt         297


<210>  340
<211>  3123
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 119 variant

<400>  340
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcgtccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gtttggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtat tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcaaa gaaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgtctaaaa cttacctgag caagaccctg gctcagtaca ccagtaaaac ctgtagtaat     2460

tgcggcttta ccatcaccag cgccgattat gaccgcgtgc tggaaaagct gaagaaaacc     2520

gccaccggct ggatgaccac catcaatggt aaagagctta aagtcgaagg gcagattact     2580

tattacaacc gttataagcg gcaaaacgtg gtgaaagatc tgtcggttga gctggaccgt     2640

ttgtctgaag aaagcgtgaa caatgatatc agctcctgga ccaaaggtcg ttccggcgaa     2700

gcgttaagtc tgttgaaaaa gcgctttagc catcgcccgg tgcaggaaaa attcgtttgc     2760

ctgaactgtg gcttcgaaac ccacgccgac gagcaagcgg cgctcaatat tgcgcgtagc     2820

tggctgttcc tgcgcagcca ggaatataaa aaatatcaaa ccaacaaaac aactggcaat     2880

accgacaagc gtgcctttgt tgaaacctgg cagagcttct atcgcaagaa gctgaaagag     2940

gtctggaaac cggcggtacc acctgcgcca aagaaaaaac gcaaagtgag cgaaaatctt     3000

tattttcaag gtagcgcatg gagtcatcct caattcgaga aaggtggagg ttctggcggt     3060

ggatcgggag gttcagcgtg gagccacccg cagttcgaaa aaggaagggg atccggctgc     3120

taa                                                                   3123


<210>  341
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 457 variant

<400>  341
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac aagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcc ccgaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaacccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  342
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 438 variant

<400>  342
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac cagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgaagc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  343
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 119 variant

<400>  343

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  344
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 457 variant

<400>  344

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Pro 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  345
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 438 variant

<400>  345

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  346
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 488 Variant

<400>  346
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagttcggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg catcgaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  347
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 491 Variant

<400>  347
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  348
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 515 Variant

<400>  348
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgccca gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  349
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 527 Variant

<400>  349
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacacgggg ccccatgaaa accctgctcg tcagagtgat gacccctgac      120

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc      180

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc      240

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt      300

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag      360

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac      420

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac      480

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat      540

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc      600

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga      660

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc      720

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag      780

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg      840

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc      900

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac      960

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     1020

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     1080

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     1140

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     1200

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     1260

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     1320

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     1380

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     1440

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     1500

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     1560

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     1620

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     1680

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     1740

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     1800

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     1860

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     1920

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     1980

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     2040

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     2100

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     2160

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     2220

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     2280

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     2340

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     2400

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     2460

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     2520

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     2580

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     2640

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     2700

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     2760

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     2820

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     2880

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtg           2934


<210>  350
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 488 Variant

<400>  350

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  351
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 491 Variant

<400>  351

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  352
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 515 Variant

<400>  352

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  353
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 527 Variant

<400>  353

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  354
<211>  3120
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  SV40 NLS-CasX-SV40 NLS-TEV cleavage site - TwinStrep tag

<400>  354
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcttccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gtttggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtat tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcagc caaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgccgtcta aaacttacct gagcaagacc ctggctcagt acaccagtaa aacctgtagt     2460

aattgcggct ttaccatcac cagcgccgat tatgaccgcg tgctggaaaa gctgaagaaa     2520

accgccaccg gctggatgac caccatcaat ggtaaagagc ttaaagtcga agggcagatt     2580

acttattaca accgttataa gcggcaaaac gtggtgaaag atctgtcggt tgagctggac     2640

cgtttgtctg aagaaagcgt gaacaatgat atcagctcct ggaccaaagg tcgttccggc     2700

gaagcgttaa gtctgttgaa aaagcgcttt agccatcgcc cggtgcagga aaaattcgtt     2760

tgcctgaact gtggcttcga aacccacgcc gacgagcaag cggcgctcaa tattgcgcgt     2820

agctggctgt tcctgcgcag ccaggaatat aaaaaatatc aaaccaacaa aacaactggc     2880

aataccgaca agcgtgcctt tgttgaaacc tggcagagct tctatcgcaa aaaactgaaa     2940

gaggtctgga aaccggcggt agcgccaaag aaaaaacgca aagtgagcga aaatctttat     3000

tttcaaggta gcgcatggag tcatcctcaa ttcgagaaag gtggaggttc tggcggtgga     3060

tcgggaggtt cagcgtggag ccacccgcag ttcgaaaaag gaaggggatc cggctgctaa     3120


<210>  355
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  355

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln 
    210                 215                 220                 


Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu 
            260                 265                 270         


Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys 
        275                 280                 285             


Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr 
    290                 295                 300                 


Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985         


<210>  356
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  356

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val 
            980                 985     


<210>  357
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  357

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  358
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  358

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro His Lys Lys 
            980                 985                 990         


Lys His Pro Asp Ala Ser Val Asn  Phe Ser Glu Phe Ser  Lys 
        995                 1000                 1005     


<210>  359
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  359

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Gln Arg Pro 
            980                 985                 990         


Gly Pro Tyr Asp Arg Pro Gln Arg  Pro Gly Pro Tyr Asp  Arg Pro 
        995                 1000                 1005         


<210>  360
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  360

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Leu Ser Pro 
            980                 985                 990         


Ser Leu Ser Pro Leu Leu Ser Pro  Ser Leu Ser Pro Leu  
        995                 1000                 1005 


<210>  361
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  361

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Arg Gly 
            980                 985                 990         


Lys Gly Gly Lys Gly Leu Gly Lys  Gly Gly Ala Lys Arg  His Arg Lys 
        995                 1000                 1005             


<210>  362
<211>  1013
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  362

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Ser Arg Arg 
            980                 985                 990         


Arg Lys Ala Asn Pro Thr Lys Leu  Ser Glu Asn Ala Lys  Lys Leu Ala 
        995                 1000                 1005             


Lys Glu  Val Glu Asn 
    1010             


<210>  363
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  363

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala 
            980                 985                 990         


Lys Arg Val Lys Leu Asp 
        995             


<210>  364
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  364

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Lys Arg Ser 
            980                 985                 990         


Phe Ser Lys Ala Phe 
        995         


<210>  365
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  365

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Lys Arg Gly 
            980                 985                 990         


Ile Asn Asp Arg Asn Phe Trp Arg  Gly Glu Asn Glu Arg  Lys Thr Arg 
        995                 1000                 1005             


<210>  366
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  366

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Met Gln Glu Ile Lys 
1               5                   10                  15      


Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys 
            20                  25                  30          


Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met 
        35                  40                  45              


Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu 
    50                  55                  60                  


Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys 
65                  70                  75                  80  


Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr 
                85                  90                  95      


Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
            100                 105                 110         


Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
        115                 120                 125             


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
    130                 135                 140                 


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
145                 150                 155                 160 


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
                165                 170                 175     


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val Pro Pro Pro  Pro Lys Lys Lys Arg  Lys Val 
        995                 1000                 1005         


<210>  367
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant Sequence

<400>  367

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Met Gln Glu Ile Lys 
1               5                   10                  15      


Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys 
            20                  25                  30          


Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met 
        35                  40                  45              


Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu 
    50                  55                  60                  


Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys 
65                  70                  75                  80  


Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr 
                85                  90                  95      


Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
            100                 105                 110         


Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
        115                 120                 125             


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
    130                 135                 140                 


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
145                 150                 155                 160 


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
                165                 170                 175     


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val Pro Pro Pro  Pro Ala Ala Lys Arg  Val Lys Leu 
        995                 1000                 1005             


Asp 
    


<210>  368
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  368
ccaaagaaga agcggaaggt c                                                 21


<210>  369
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  369
cacaagaaga aacatccaga cgcatcagtc aactttagcg agttcagtaa a                51


<210>  370
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  370
cagcgccctg ggccttacga taggccgcaa agacccggac cgtatgatcg ccct             54


<210>  371
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  371
ctcagcccga gtcttagtcc actgctttcc ccgtccctgt ctccactg                    48


<210>  372
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  372
cggggcaagg gtggcaaggg gcttggcaag gggggggcaa agaggcacag gaag             54


<210>  373
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  373
agccgccgca gaaaagccaa tcctacaaaa ctgtcagaaa atgcgaaaaa acttgctaag       60

gaggtggaaa a                                                            71


<210>  374
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  374
cctgccgcaa agcgagtgaa attggac                                           27


<210>  375
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  375
aagcggtcct tcagtaaggc cttt                                              24


<210>  376
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  376
aaacggggaa taaacgaccg gaacttctgg cgcggggaaa acgagcgcaa aacccga          57


<210>  377
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  nuclear localization sequence

<400>  377

His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210>  378
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 387 Variant Sequence

<400>  378
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca gggagagcaa tcaccctgtg      660

aagcccctgg aacagatcgg cggcaatagc tgtgcctctg gacctgtggg aaaagccctg      720

agcgacgcct gtatgggagc cgtggcatcc ttcctgacca agtaccagga catcatcctg      780

gaacaccaga aagtgatcaa gaagaacgag aaaagactgg ccaacctcaa ggatatcgcc      840

agcgctaacg gcctggcctt tcctaagatc accctgcctc cacagcctca caccaaagag      900

ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga tttgggtcaa cctgaatctg      960

tggcagaagc tgaagatcgg cagggacgaa gccaagccac tgcagagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagttc ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcatcgac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  379
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 395 Variant Sequence

<400>  379
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagttcggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg catcgaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  380
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 485 Variant Sequence

<400>  380
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggaggaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  381
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 486 Variant Seqence

<400>  381
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctga agcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggaggaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  382
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 487 Variant Sequence

<400>  382
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  383
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 488 Variant Sequence

<400>  383
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagttc ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcatcgac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  384
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 489 Variant Sequence

<400>  384
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggag gaagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  385
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 490 Variant Sequence

<400>  385
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgaagcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggag gaagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  386
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 491 Variant Sequence

<400>  386
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  387
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 495 Variant Sequence

<400>  387
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca gggagagcaa tcaccctgtg      660

aagcccctgg aacagatcgg cggcaatagc tgtgcctctg gacctgtggg aaaagccctg      720

agcgacgcct gtatgggagc cgtggcatcc ttcctgacca agtaccagga catcatcctg      780

gaacaccaga aagtgatcaa gaagaacgag aaaagactgg ccaacctcaa ggatatcgcc      840

agcgctaacg gcctggcctt tcctaagatc accctgcctc cacagcctca caccaaagag      900

ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga tttgggtcaa cctgaatctg      960

tggcagaagc tgaagatcgg cagggacgaa gccaagccac tgcagagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  388
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 387 Variant Sequence

<400>  388

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  389
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 395 Variant Sequence

<400>  389

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val Thr Ser Pro Lys  Lys Lys Arg Lys Val  
        995                 1000                 1005 


<210>  390
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 485 Variant Sequence

<400>  390

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  391
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 486 Variant Seqence

<400>  391

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  392
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 487 Variant Sequence

<400>  392

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  393
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 488 Variant Sequence

<400>  393

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  394
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 489 Variant Sequence

<400>  394

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  395
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 490 Variant Sequence

<400>  395

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  396
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 491 Variant Sequence

<400>  396

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  397
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 495 Variant Sequence

<400>  397

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  398
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  T7 promoter primer

<400>  398
gaaattaata cgactcacta ta                                                22


<210>  399
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg2 backbone fwd

<400>  399
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaag                                           87


<210>  400
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg2 backbone rev

<400>  400
ctttgatgct tcttatttat cggatttctc tccgataaat aagcgcttta cccatacgac       60

atagtcgctg gtgatggc                                                     78


<210>  401
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg2.7.37 spacer primer

<400>  401
cggagcgaga catctcggcc ctttgatgct tcttatttat cggatttctc tccg             54


<210>  402
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg32 backbone fwd

<400>  402
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  403
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg32 backbone rev

<400>  403
ctttgatgct tccctccgaa gagggcgctt tacccatacg acatag                      46


<210>  404
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg32.7.37 spacer primer

<400>  404
cggagcgaga catctcggcc ctttgatgct tccctccgaa gag                         43


<210>  405
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg64 backbone fwd

<400>  405
gaaattaata cgactcacta taggtactgg cgcctttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  406
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg64 backbone rev

<400>  406
ctttgatgct tcttacggac cgaagtccgt aagcgcttta cccatacgac atag             54


<210>  407
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg64.7.37 spacer primer

<400>  407
cggagcgaga catctcggcc ctttgatgct tcttacggac cgaag                       45


<210>  408
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg174 backbone fwd

<400>  408
gaaattaata cgactcacta taactggcgc ttttatctga ttactttgag agccatcacc       60

agcgactatg tcgtagtggg taaagct                                           87


<210>  409
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg174 backbone rev

<400>  409
ctttgatgct ccctccgaag agggagcttt acccactacg acatagtcgc                  50


<210>  410
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg174.7.37 spacer primer

<400>  410
cggagcgaga catctcggcc ctttgatgct ccctcc                                 36


<210>  411
<211>  130
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  411
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag ggccgagaug      120

ucucgcuccg                                                             130


<210>  412
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  412
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgccc ucuucggagg gaagcaucaa agggccgaga ugucucg                    107


<210>  413
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  413
gguacuggcg ccuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag ggccgagaug ucucgcuccg      120


<210>  414
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  414
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaagg gccgagaugu cucgcuccg                  109


<210>  415
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target oligo

<400>  415
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  416
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target oligo

<400>  416
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  417
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target sequence

<400>  417
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgaatgct gtcagcttca       60


<210>  418
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target sequence

<400>  418
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  419
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target sequence

<400>  419
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgagtgct gtcagcttca       60


<210>  420
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target sequence

<400>  420
tgaagctgac agcactcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  421
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target sequence

<400>  421
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgactgct gtcagcttca       60


<210>  422
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target sequence

<400>  422
tgaagctgac agcagtcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  423
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target sequence

<400>  423
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgattgct gtcagcttca       60


<210>  424
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA target sequence

<400>  424
tgaagctgac agcaatcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  425
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA spacer sequence

<400>  425
ctgcattcta gttgtggttt                                                   20


<210>  426
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA plasmid sequence

<400>  426
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagc tgcattctag ttgtggttt                  109


<210>  427
<211>  4557
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP10 plasmid

<400>  427
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ccgctcctaa gaacatcgac cagagaaagc tgatccccgt gaaggacggc     1920

aacgagagac tgacctctag cggctttgcc tgcagccagt gttgccagcc tctgtacgtg     1980

tacaagctgg aacaagtgaa cgacaagggc aagccccaca ccaactactt cggcagatgc     2040

aacgtgtccg agcacgagag gctgatcctg ctgtctcctc acaagcccga ggccaacgat     2100

gagctggtca catacagcct gggcaagttc ggacagagag ccctggactt ctacagcatc     2160

cacgtgacca gggagagcaa tcaccctgtg aagcccctgg aacagatcgg cggcaatagc     2220

tgtgcctctg gacctgtggg aaaagccctg agcgacgcct gtatgggagc cgtggcatcc     2280

ttcctgacca agtaccagga catcatcctg gaacaccaga aagtgatcaa gaagaacgag     2340

aaaagactgg ccaacctcaa ggatatcgcc agcgctaacg gcctggcctt tcctaagatc     2400

accctgcctc cacagcctca caccaaagag ggcatcgagg cctacaacaa cgtggtggcc     2460

cagatcgtga tttgggtcaa cctgaatctg tggcagaagc tgaagatcgg cagggacgaa     2520

gccaagccac tgcagagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     2580

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     2640

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     2700

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagttc     2760

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     2820

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     2880

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     2940

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     3000

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     3060

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     3120

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     3180

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     3240

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     3300

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     3360

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     3420

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     3480

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcatcgac     3540

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     3600

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     3660

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     3720

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     3780

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     3840

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     3900

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     3960

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     4020

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     4080

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     4140

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     4200

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     4260

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     4320

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     4380

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     4440

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt     4500

ccaaaaaaga agagaaaggt agccctcgag tacccatatg atgtccctga ctacgct        4557


<210>  428
<211>  4557
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP11 plasmid

<400>  428
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ccgctcctaa gaacatcgac cagagaaagc tgatccccgt gaaggacggc     1920

aacgagagac tgacctctag cggctttgcc tgcagccagt gttgccagcc tctgtacgtg     1980

tacaagctgg aacaagtgaa cgacaagggc aagccccaca ccaactactt cggcagatgc     2040

aacgtgtccg agcacgagag gctgatcctg ctgtctcctc acaagcccga ggccaacgat     2100

gagctggtca catacagcct gggcaagttc ggacagagag ccctggactt ctacagcatc     2160

cacgtgacca gggagagcaa tcaccctgtg aagcccctgg aacagatcgg cggcaatagc     2220

tgtgcctctg gacctgtggg aaaagccctg agcgacgcct gtatgggagc cgtggcatcc     2280

ttcctgacca agtaccagga catcatcctg gaacaccaga aagtgatcaa gaagaacgag     2340

aaaagactgg ccaacctcaa ggatatcgcc agcgctaacg gcctggcctt tcctaagatc     2400

accctgcctc cacagcctca caccaaagag ggcatcgagg cctacaacaa cgtggtggcc     2460

cagatcgtga tttgggtcaa cctgaatctg tggcagaagc tgaagatcgg cagggacgaa     2520

gccaagccac tgcagagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     2580

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     2640

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     2700

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     2760

ggcgacctgc tgaagcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     2820

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     2880

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     2940

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     3000

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     3060

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     3120

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     3180

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     3240

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     3300

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     3360

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     3420

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     3480

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     3540

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     3600

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     3660

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     3720

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     3780

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     3840

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     3900

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     3960

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     4020

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     4080

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggag gaagaggcag     4140

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     4200

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     4260

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     4320

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     4380

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     4440

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt     4500

ccaaaaaaga agagaaaggt agccctcgag tacccatatg atgtccctga ctacgct        4557


<210>  429
<211>  4557
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP12 plasmid

<400>  429
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ccgctcctaa gaacatcgac cagagaaagc tgatccccgt gaaggacggc     1920

aacgagagac tgacctctag cggctttgcc tgcagccagt gttgccagcc tctgtacgtg     1980

tacaagctgg aacaagtgaa cgacaagggc aagccccaca ccaactactt cggcagatgc     2040

aacgtgtccg agcacgagag gctgatcctg ctgtctcctc acaagcccga ggccaacgat     2100

gagctggtca catacagcct gggcaagttc ggacagagag ccctggactt ctacagcatc     2160

cacgtgacca gggagagcaa tcaccctgtg aagcccctgg aacagatcgg cggcaatagc     2220

tgtgcctctg gacctgtggg aaaagccctg agcgacgcct gtatgggagc cgtggcatcc     2280

ttcctgacca agtaccagga catcatcctg gaacacaaga aagtgatcaa gaagaacgag     2340

aaaagactgg ccaacctcaa ggatatcgcc agcgctaacg gcctggcctt tcctaagatc     2400

accctgcctc cacagcctca caccaaagag ggcatcgagg cctacaacaa cgtggtggcc     2460

cagatcgtga tttgggtcaa cctgaatctg tggcagaagc tgaagatcgg cagggacgaa     2520

gccaagccac tgcagagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     2580

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     2640

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     2700

ccttacctga gcagccccga ggaccggaag aagggcaaga agttcgccag ataccagctg     2760

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     2820

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     2880

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     2940

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     3000

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     3060

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     3120

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     3180

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     3240

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     3300

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     3360

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     3420

cccctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     3480

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     3540

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     3600

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     3660

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     3720

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     3780

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     3840

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     3900

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     3960

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     4020

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     4080

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggag gaagaggcag     4140

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     4200

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     4260

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     4320

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     4380

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     4440

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt     4500

ccaaaaaaga agagaaaggt agccctcgag tacccatatg atgtccctga ctacgct        4557


<210>  430
<211>  4620
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  psPax2 plasmid sequence

<400>  430
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccagta aaattaaagc     1800

caggaatgga tggcccaaaa gttaaacaat ggccattgac agaagaaaaa ataaaagcat     1860

tagtagaaat ttgtacagaa atggaaaagg aaggaaaaat ttcaaaaatt gggcctgaaa     1920

atccatacaa tactccagta tttgccataa agaaaaaaga cagtactaaa tggagaaaat     1980

tagtagattt cagagaactt aataagagaa ctcaagattt ctgggaagtt caattaggaa     2040

taccacatcc tgcagggtta aaacagaaaa aatcagtaac agtactggat gtgggcgatg     2100

catatttttc agttccctta gataaagact tcaggaagta tactgcattt accataccta     2160

gtataaacaa tgagacacca gggattagat atcagtacaa tgtgcttcca cagggatgga     2220

aaggatcacc agcaatattc cagtgtagca tgacaaaaat cttagagcct tttagaaaac     2280

aaaatccaga catagtcatc tatcaataca tggatgattt gtatgtagga tctgacttag     2340

aaatagggca gcatagaaca aaaatagagg aactgagaca acatctgttg aggtggggat     2400

ttaccacacc agacaaaaaa catcagaaag aacctccatt cctttggatg ggttatgaac     2460

tccatcctga taaatggaca gtacagccta tagtgctgcc agaaaaggac agctggactg     2520

tcaatgacat acagaaatta gtgggaaaat tgaattgggc aagtcagatt tatgcaggga     2580

ttaaagtaag gcaattatgt aaacttctta ggggaaccaa agcactaaca gaagtagtac     2640

cactaacaga agaagcagag ctagaactgg cagaaaacag ggagattcta aaagaaccgg     2700

tacatggagt gtattatgac ccatcaaaag acttaatagc agaaatacag aagcaggggc     2760

aaggccaatg gacatatcaa atttatcaag agccatttaa aaatctgaaa acaggaaagt     2820

atgcaagaat gaagggtgcc cacactaatg atgtgaaaca attaacagag gcagtacaaa     2880

aaatagccac agaaagcata gtaatatggg gaaagactcc taaatttaaa ttacccatac     2940

aaaaggaaac atgggaagca tggtggacag agtattggca agccacctgg attcctgagt     3000

gggagtttgt caatacccct cccttagtga agttatggta ccagttagag aaagaaccca     3060

taataggagc agaaactttc tatgtagatg gggcagccaa tagggaaact aaattaggaa     3120

aagcaggata tgtaactgac agaggaagac aaaaagttgt ccccctaacg gacacaacaa     3180

atcagaagac tgagttacaa gcaattcatc tagctttgca ggattcggga ttagaagtaa     3240

acatagtgac agactcacaa tatgcattgg gaatcattca agcacaacca gataagagtg     3300

aatcagagtt agtcagtcaa ataatagagc agttaataaa aaaggaaaaa gtctacctgg     3360

catgggtacc agcacacaaa ggaattggag gaaatgaaca agtagataaa ttggtcagtg     3420

ctggaatcag gaaagtacta tttttagatg gaatagataa ggcccaagaa gaacatgaga     3480

aatatcacag taattggaga gcaatggcta gtgattttaa cctaccacct gtagtagcaa     3540

aagaaatagt agccagctgt gataaatgtc agctaaaagg ggaagccatg catggacaag     3600

tagactgtag cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct     3660

tggtagcagt tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag     3720

ggcaagaaac agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac     3780

atacagacaa tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg     3840

ggatcaagca ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta     3900

tgaataaaga attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga     3960

cagcagtaca aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt     4020

acagtgcagg ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac     4080

aaaaacaaat tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag     4140

tttggaaagg accagcaaag ctcctctgga aaggtgaagg ggcagtagta atacaagata     4200

atagtgacat aaaagtagtg ccaagaagaa aagcaaagat catcagggat tatggaaaac     4260

agatggcagg tgatgattgt gtggcaagta gacaggatga ggattaacac atggaattct     4320

gcaacaactg ctgtttatcc atttcagaat tgggtgtcga catagcagaa taggcgttac     4380

tcgacagagg agagcaagaa atggagccag tagatcctag actagagccc tggaagcatc     4440

caggaagtca gcctaaaact gcttgtacca attgctattg taaaaagtgt tgctttcatt     4500

gccaagtttg tttcatgaca aaagccttag gcatctccta tggcaggaag aagcggagac     4560

agcgacgaag agctcatcag aacagtcaga ctcatcaagc ttctctatca aagcagtaag     4620


<210>  431
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 plasmid sequence

<400>  431
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  432
<211>  4563
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid Sequence

<400>  432
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tga                                                                   4563


<210>  433
<211>  4620
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-(-1)-POL plasmid sequence

<400>  433
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccagta aaattaaagc     1800

caggaatgga tggcccaaaa gttaaacaat ggccattgac agaagaaaaa ataaaagcat     1860

tagtagaaat ttgtacagaa atggaaaagg aaggaaaaat ttcaaaaatt gggcctgaaa     1920

atccatacaa tactccagta tttgccataa agaaaaaaga cagtactaaa tggagaaaat     1980

tagtagattt cagagaactt aataagagaa ctcaagattt ctgggaagtt caattaggaa     2040

taccacatcc tgcagggtta aaacagaaaa aatcagtaac agtactggat gtgggcgatg     2100

catatttttc agttccctta gataaagact tcaggaagta tactgcattt accataccta     2160

gtataaacaa tgagacacca gggattagat atcagtacaa tgtgcttcca cagggatgga     2220

aaggatcacc agcaatattc cagtgtagca tgacaaaaat cttagagcct tttagaaaac     2280

aaaatccaga catagtcatc tatcaataca tggatgattt gtatgtagga tctgacttag     2340

aaatagggca gcatagaaca aaaatagagg aactgagaca acatctgttg aggtggggat     2400

ttaccacacc agacaaaaaa catcagaaag aacctccatt cctttggatg ggttatgaac     2460

tccatcctga taaatggaca gtacagccta tagtgctgcc agaaaaggac agctggactg     2520

tcaatgacat acagaaatta gtgggaaaat tgaattgggc aagtcagatt tatgcaggga     2580

ttaaagtaag gcaattatgt aaacttctta ggggaaccaa agcactaaca gaagtagtac     2640

cactaacaga agaagcagag ctagaactgg cagaaaacag ggagattcta aaagaaccgg     2700

tacatggagt gtattatgac ccatcaaaag acttaatagc agaaatacag aagcaggggc     2760

aaggccaatg gacatatcaa atttatcaag agccatttaa aaatctgaaa acaggaaagt     2820

atgcaagaat gaagggtgcc cacactaatg atgtgaaaca attaacagag gcagtacaaa     2880

aaatagccac agaaagcata gtaatatggg gaaagactcc taaatttaaa ttacccatac     2940

aaaaggaaac atgggaagca tggtggacag agtattggca agccacctgg attcctgagt     3000

gggagtttgt caatacccct cccttagtga agttatggta ccagttagag aaagaaccca     3060

taataggagc agaaactttc tatgtagatg gggcagccaa tagggaaact aaattaggaa     3120

aagcaggata tgtaactgac agaggaagac aaaaagttgt ccccctaacg gacacaacaa     3180

atcagaagac tgagttacaa gcaattcatc tagctttgca ggattcggga ttagaagtaa     3240

acatagtgac agactcacaa tatgcattgg gaatcattca agcacaacca gataagagtg     3300

aatcagagtt agtcagtcaa ataatagagc agttaataaa aaaggaaaaa gtctacctgg     3360

catgggtacc agcacacaaa ggaattggag gaaatgaaca agtagataaa ttggtcagtg     3420

ctggaatcag gaaagtacta tttttagatg gaatagataa ggcccaagaa gaacatgaga     3480

aatatcacag taattggaga gcaatggcta gtgattttaa cctaccacct gtagtagcaa     3540

aagaaatagt agccagctgt gataaatgtc agctaaaagg ggaagccatg catggacaag     3600

tagactgtag cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct     3660

tggtagcagt tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag     3720

ggcaagaaac agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac     3780

atacagacaa tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg     3840

ggatcaagca ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta     3900

tgaataaaga attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga     3960

cagcagtaca aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt     4020

acagtgcagg ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac     4080

aaaaacaaat tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag     4140

tttggaaagg accagcaaag ctcctctgga aaggtgaagg ggcagtagta atacaagata     4200

atagtgacat aaaagtagtg ccaagaagaa aagcaaagat catcagggat tatggaaaac     4260

agatggcagg tgatgattgt gtggcaagta gacaggatga ggattaacac atggaattct     4320

gcaacaactg ctgtttatcc atttcagaat tgggtgtcga catagcagaa taggcgttac     4380

tcgacagagg agagcaagaa atggagccag tagatcctag actagagccc tggaagcatc     4440

caggaagtca gcctaaaact gcttgtacca attgctattg taaaaagtgt tgctttcatt     4500

gccaagtttg tttcatgaca aaagccttag gcatctccta tggcaggaag aagcggagac     4560

agcgacgaag agctcatcag aacagtcaga ctcatcaagc ttctctatca aagcagtaag     4620


<210>  434
<211>  4560
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid sequence

<400>  434
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560


<210>  435
<211>  4869
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X-PR plasmid sequence

<400>  435
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tcctttagct tccctcagat cactctttgg cagcgacccc tcgtcacaat aaagataggg     4620

gggcaattaa aggaagctct attagataca ggagcagatg atacagtatt agaagaaatg     4680

aatttgccag gaagatggaa accaaaaatg atagggggaa ttggaggttt tatcaaagta     4740

agacagtatg atcagatact catagaaatc tgcggacata aagctatagg tacagtatta     4800

gtaggaccta cacctgtcaa cataattgga agaaatctgt tgactcagat tggctgcact     4860

ttaaatttt                                                             4869


<210>  436
<211>  4563
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid sequence

<400>  436
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tga                                                                   4563


<210>  437
<211>  1536
<212>  DNA
<213>  Vesiculovirus Vesicular stomatitis virus

<400>  437
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  438
<211>  511
<212>  PRT
<213>  Vesiculovirus Vesicular stomatitis virus

<400>  438

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  439
<211>  1536
<212>  DNA
<213>  Lentivirus Human immunodeficiency virus

<400>  439
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  440
<211>  511
<212>  PRT
<213>  Lentivirus Human immunodeficiency virus

<400>  440

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  441
<211>  2571
<212>  DNA
<213>  Alpharetrovirus Avian leukosis virus

<400>  441
atgagagtga aggagaaata tcagcacttg tggagatggg ggtggagatg gggcaccatg       60

ctccttggga tgttgatgat ctgtagtgct acagaaaaat tgtgggtcac agtctattat      120

ggggtacctg tgtggaagga agcaaccacc actctatttt gtgcatcaga tgctaaagca      180

tatgatacag aggtacataa tgtttgggcc acacatgcct gtgtacccac agaccccaac      240

ccacaagaag tagtattggt aaatgtgaca gaaaatttta acatgtggaa aaatgacatg      300

gtagaacaga tgcatgagga tataatcagt ttatgggatc aaagcctaaa gccatgtgta      360

aaattaaccc cactctgtgt tagtttaaag tgcactgatt tgaagaatga tactaatacc      420

aatagtagta gcgggagaat gataatggag aaaggagaga taaaaaactg ctctttcaat      480

atcagcacaa gcataagagg taaggtgcag aaagaatatg cattttttta taaacttgat      540

ataataccaa tagataatga tactaccagc tataagttga caagttgtaa cacctcagtc      600

attacacagg cctgtccaaa ggtatccttt gagccaattc ccatacatta ttgtgccccg      660

gctggttttg cgattctaaa atgtaataat aagacgttca atggaacagg accatgtaca      720

aatgtcagca cagtacaatg tacacatgga attaggccag tagtatcaac tcaactgctg      780

ttaaatggca gtctagcaga agaagaggta gtaattagat ctgtcaattt cacggacaat      840

gctaaaacca taatagtaca gctgaacaca tctgtagaaa ttaattgtac aagacccaac      900

aacaatacaa gaaaaagaat ccgtatccag agaggaccag ggagagcatt tgttacaata      960

ggaaaaatag gaaatatgag acaagcacat tgtaacatta gtagagcaaa atggaataac     1020

actttaaaac agatagctag caaattaaga gaacaatttg gaaataataa aacaataatc     1080

tttaagcaat cctcaggagg ggacccagaa attgtaacgc acagttttaa ttgtggaggg     1140

gaatttttct actgtaattc aacacaactg tttaatagta cttggtttaa tagtacttgg     1200

agtactgaag ggtcaaataa cactgaagga agtgacacaa tcaccctccc atgcagaata     1260

aaacaaatta taaacatgtg gcagaaagta ggaaaagcaa tgtatgcccc tcccatcagt     1320

ggacaaatta gatgttcatc aaatattaca gggctgctat taacaagaga tggtggtaat     1380

agcaacaatg agtccgagat cttcagacct ggaggaggag atatgaggga caattggaga     1440

agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc acccaccaag     1500

gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc tttgttcctt     1560

gggttcttgg gagcagcagg aagcactatg ggcgcagcct caatgacgct gacggtacag     1620

gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag ggctattgag     1680

gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca ggcaagaatc     1740

ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg ttgctctgga     1800

aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa atctctggaa     1860

cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa ttacacaagc     1920

ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga acaagaatta     1980

ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa ttggctgtgg     2040

tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat agtttttgct     2100

gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt tcagacccac     2160

ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg tggagagaga     2220

gacagagaca gatccattcg attagtgaac ggatccttgg cacttatctg ggacgatctg     2280

cggagcctgt gcctcttcag ctaccaccgc ttgagagact tactcttgat tgtaacgagg     2340

attgtggaac ttctgggacg cagggggtgg gaagccctca aatattggtg gaatctccta     2400

cagtattgga gtcaggaact aaagaatagt gctgttagct tgctcaatgc cacagccata     2460

gcagtagctg aggggacaga tagggttata gaagtagtac aaggagcttg tagagctatt     2520

cgccacatac ctagaagaat aagacagggc ttggaaagga ttttgctata a              2571


<210>  442
<211>  856
<212>  PRT
<213>  Alpharetrovirus Avian leukosis virus

<400>  442

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 


Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 


His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         


Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 


Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         


Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         


Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     


<210>  443
<211>  1806
<212>  DNA
<213>  Alpharetrovirus Rous sarcoma virus

<400>  443
atggaagccg tcataaaggc atttctgact ggataccctg ggaagacgag caagaaggac       60

tccaaggaga aaccgctagc aacaagcaag aaagacccgg agaagacacc cttgctgcca      120

acgagagtta attatattct cattattggt gtcctggtct tgtgtgaggt tacgggggta      180

agagctgatg ttcacttact cgagcagcca gggaaccttt ggattacatg ggccaaccgt      240

acaggccaaa cggatttctg cctctctaca cagtcagcca cctccccttt tcaaacatgt      300

ttgataggta tcccgtctcc tatttccgaa ggtgatttta agggatatgt ttctgataca      360

aattgctcca ctgtgggaac tgaccggtta gtcttgtcag ccagcattac cggcggccct      420

gacaacagca ccaccctcac ttatcgaaag gtttcatgcc tgctgttaaa gctgaacgtc      480

tccatgtggg atgagccacc tgaactgcag ctgctaggtt cccagtctct ccctaacgtt      540

actaacatta ctcaggtctc tggcgtggcc gggggatgtg tatatttcgc cccaagggcc      600

actggcctgt ttttaggttg gtctaaacaa ggtctctcgc ggttcctcct ccgtcacccc      660

tttacctcca cctctaactc cacggaaccg ttcacggtgg tgacagcgga tagacacaat      720

ctttttatgg ggagtgagta ctgtggtgca tatggctaca gattttggga aatatataac      780

tgctcacaga ctaggaatac ttaccgctgt ggagacgtgg gaggtactgg cctccctgaa      840

acctggtgca gaggaaaagg aggtatatgg gttaatcaat caaaggaaat taatgagaca      900

gagccgttca gttttactgc gaactgtact ggcagtaatt tgggtaatgt cagcggatgt      960

tgcggagaac caatcacgat tctcccacta ggggcatgga tcgacagtac gcaaggtagt     1020

ttcactaaac caaaagcgct accacccgca attttcctca tttgtgggga tcgcgcatgg     1080

caaggaattc ccagtcgtcc ggtagggggc ccctgctatt taggcaagct taccatgtta     1140

gcacccaacc atacagatat tctcaaaata cttgctaatt cgtcgcggac aggtataaga     1200

cgtaaacgaa gcgtctcaca cctggatgat acatgctcag atgaagtaca gctttggggt     1260

cctacagcaa gaatctttgc atctatctta gccccggggg tagcagctgc gcaagcctta     1320

agagaaattg agagactagc ctgttggtcc gttaaacagg ctaacttgac aacatcactc     1380

ctcggggact tattggatga tgtcacgagt attcgacacg cggtcctgca gaaccgagcg     1440

gctattgact tcttgcttct agctcacggc catggctgtg aggacgttgc cggaatgtgt     1500

tgtttcaatc tgagtgatca cagtgaatct atacagaaga agttccagct aatgaagaaa     1560

catgtcaata agatcggcgt ggacagcgac ccaatcggaa gttggctgcg agggatattc     1620

gggggaatag gggaatgggc cgttcatctg ctaaaaggac tgcttttggg gcttgtagtt     1680

attttattgc tactggtgtg cctgccttgc cttttacaat ttgtgtctag tagtattcga     1740

aagatgatta atagttcaat caactatcat actgaataca ggaagatgca gggcggagca     1800

gtctag                                                                1806


<210>  444
<211>  601
<212>  PRT
<213>  Alpharetrovirus Rous sarcoma virus

<400>  444

Met Glu Ala Val Ile Lys Ala Phe Leu Thr Gly Tyr Pro Gly Lys Thr 
1               5                   10                  15      


Ser Lys Lys Asp Ser Lys Glu Lys Pro Leu Ala Thr Ser Lys Lys Asp 
            20                  25                  30          


Pro Glu Lys Thr Pro Leu Leu Pro Thr Arg Val Asn Tyr Ile Leu Ile 
        35                  40                  45              


Ile Gly Val Leu Val Leu Cys Glu Val Thr Gly Val Arg Ala Asp Val 
    50                  55                  60                  


His Leu Leu Glu Gln Pro Gly Asn Leu Trp Ile Thr Trp Ala Asn Arg 
65                  70                  75                  80  


Thr Gly Gln Thr Asp Phe Cys Leu Ser Thr Gln Ser Ala Thr Ser Pro 
                85                  90                  95      


Phe Gln Thr Cys Leu Ile Gly Ile Pro Ser Pro Ile Ser Glu Gly Asp 
            100                 105                 110         


Phe Lys Gly Tyr Val Ser Asp Thr Asn Cys Ser Thr Val Gly Thr Asp 
        115                 120                 125             


Arg Leu Val Leu Ser Ala Ser Ile Thr Gly Gly Pro Asp Asn Ser Thr 
    130                 135                 140                 


Thr Leu Thr Tyr Arg Lys Val Ser Cys Leu Leu Leu Lys Leu Asn Val 
145                 150                 155                 160 


Ser Met Trp Asp Glu Pro Pro Glu Leu Gln Leu Leu Gly Ser Gln Ser 
                165                 170                 175     


Leu Pro Asn Val Thr Asn Ile Thr Gln Val Ser Gly Val Ala Gly Gly 
            180                 185                 190         


Cys Val Tyr Phe Ala Pro Arg Ala Thr Gly Leu Phe Leu Gly Trp Ser 
        195                 200                 205             


Lys Gln Gly Leu Ser Arg Phe Leu Leu Arg His Pro Phe Thr Ser Thr 
    210                 215                 220                 


Ser Asn Ser Thr Glu Pro Phe Thr Val Val Thr Ala Asp Arg His Asn 
225                 230                 235                 240 


Leu Phe Met Gly Ser Glu Tyr Cys Gly Ala Tyr Gly Tyr Arg Phe Trp 
                245                 250                 255     


Glu Ile Tyr Asn Cys Ser Gln Thr Arg Asn Thr Tyr Arg Cys Gly Asp 
            260                 265                 270         


Val Gly Gly Thr Gly Leu Pro Glu Thr Trp Cys Arg Gly Lys Gly Gly 
        275                 280                 285             


Ile Trp Val Asn Gln Ser Lys Glu Ile Asn Glu Thr Glu Pro Phe Ser 
    290                 295                 300                 


Phe Thr Ala Asn Cys Thr Gly Ser Asn Leu Gly Asn Val Ser Gly Cys 
305                 310                 315                 320 


Cys Gly Glu Pro Ile Thr Ile Leu Pro Leu Gly Ala Trp Ile Asp Ser 
                325                 330                 335     


Thr Gln Gly Ser Phe Thr Lys Pro Lys Ala Leu Pro Pro Ala Ile Phe 
            340                 345                 350         


Leu Ile Cys Gly Asp Arg Ala Trp Gln Gly Ile Pro Ser Arg Pro Val 
        355                 360                 365             


Gly Gly Pro Cys Tyr Leu Gly Lys Leu Thr Met Leu Ala Pro Asn His 
    370                 375                 380                 


Thr Asp Ile Leu Lys Ile Leu Ala Asn Ser Ser Arg Thr Gly Ile Arg 
385                 390                 395                 400 


Arg Lys Arg Ser Val Ser His Leu Asp Asp Thr Cys Ser Asp Glu Val 
                405                 410                 415     


Gln Leu Trp Gly Pro Thr Ala Arg Ile Phe Ala Ser Ile Leu Ala Pro 
            420                 425                 430         


Gly Val Ala Ala Ala Gln Ala Leu Arg Glu Ile Glu Arg Leu Ala Cys 
        435                 440                 445             


Trp Ser Val Lys Gln Ala Asn Leu Thr Thr Ser Leu Leu Gly Asp Leu 
    450                 455                 460                 


Leu Asp Asp Val Thr Ser Ile Arg His Ala Val Leu Gln Asn Arg Ala 
465                 470                 475                 480 


Ala Ile Asp Phe Leu Leu Leu Ala His Gly His Gly Cys Glu Asp Val 
                485                 490                 495     


Ala Gly Met Cys Cys Phe Asn Leu Ser Asp His Ser Glu Ser Ile Gln 
            500                 505                 510         


Lys Lys Phe Gln Leu Met Lys Lys His Val Asn Lys Ile Gly Val Asp 
        515                 520                 525             


Ser Asp Pro Ile Gly Ser Trp Leu Arg Gly Ile Phe Gly Gly Ile Gly 
    530                 535                 540                 


Glu Trp Ala Val His Leu Leu Lys Gly Leu Leu Leu Gly Leu Val Val 
545                 550                 555                 560 


Ile Leu Leu Leu Leu Val Cys Leu Pro Cys Leu Leu Gln Phe Val Ser 
                565                 570                 575     


Ser Ser Ile Arg Lys Met Ile Asn Ser Ser Ile Asn Tyr His Thr Glu 
            580                 585                 590         


Tyr Arg Lys Met Gln Gly Gly Ala Val 
        595                 600     


<210>  445
<211>  1467
<212>  DNA
<213>  Betaretrovirus Mouse mammary tumor virus

<400>  445
atgggtaagt ttctcgccac tttgatttta ttcttccagt tctgccccct catcttcggt       60

gattacagcc ccagctgctg tactctcaca attggagtct cctcatacca ctctaaaccc      120

tgcaatcctg cccagccagt ttgttcgtgg accctcgacc tgctggccct ttcagcagat      180

caggccctac agcccccctg ccctaaccta gtaagttact ccagctacca tgccacctat      240

tccctatatc tattccctca ttggactaag aagccaaacc gaaatggcgg aggctattat      300

tcagcctctt attcagaccc ttgttcctta aagtgcccat acctggggtg ccaatcatgg      360

acctgcccct atacaggagc cgtctccagc ccctactgga agtttcaaca cgatgtcaat      420

tttactcaag aagtttcacg cctcaatatt aatctccatt tttcaaaatg cggttttccc      480

ttctcccttc tagtcgacgc tccaggatat gaccccatct ggttccttaa taccgaaccc      540

agccaactgc ctcccaccgc ccctcctcta ctcccccact ctaacctaga ccacatcctc      600

gagccctcta taccatggaa atcaaaactc ctgacccttg tccagttaac cctacaaagc      660

actaattata cttgcattgt ctgtatcgat cgtgccagcc tctccacttg gcacgtccta      720

tactctccca acgtctctgt tccatcctct tcttctaccc ccctccttta cccatcgtta      780

gcgcttccag ccccccacct gacgttacca tttaactgga cccactgctt tgacccccag      840

attcaagcta tagtctcctc cccctgtcat aactccctca tcctgccccc cttttccttg      900

tcacctgttc ccaccctagg atcccgctcc cgccgagcgg taccggtggc ggtctggctt      960

gtctccgccc tggccatggg agccggagtg gctggcggga ttaccggctc catgtccctc     1020

gcctcaggaa agagcctcct acatgaggtg gacaaagata tttcccagtt aactcaagca     1080

atagtcaaaa accacaaaaa tctactcaaa attgcgcagt atgctgccca gaacagacga     1140

ggccttgatc tcctgttctg ggagcaagga ggattatgca aagcattaca agaacagtgc     1200

cgttttccga atattaccaa ttcccatgtc ccaatactac aagaaagacc cccccttgag     1260

aatcgagtcc tgactggctg gggccttaac tgggaccttg gcctctcaca gtgggctcga     1320

gaggccttac aaactggaat cacccttgtt gcgctactcc ttcttgttat ccttgcagga     1380

ccatgcatcc tccgtcagct acgacacctc ccctcgcgcg tcagataccc ccattactct     1440

cttataaaac ctgagtcatc cctgtaa                                         1467


<210>  446
<211>  688
<212>  PRT
<213>  Betaretrovirus Mouse mammary tumor virus

<400>  446

Met Pro Lys His Gln Ser Gly Ser Pro Thr Asp Ser Ser Asp Leu Leu 
1               5                   10                  15      


Leu Ser Gly Lys Lys Gln Arg Pro His Leu Ala Leu Arg Arg Lys Arg 
            20                  25                  30          


Arg Arg Glu Met Arg Lys Ile Asn Arg Lys Val Pro Arg Met Asn Leu 
        35                  40                  45              


Val Pro Ile Lys Glu Lys Thr Ala Trp Gln His Leu Gln Ala Leu Ile 
    50                  55                  60                  


Ser Glu Ala Glu Glu Val Leu Lys Thr Ser Gln Thr Pro Gln Thr Ser 
65                  70                  75                  80  


Leu Thr Leu Phe Leu Ala Leu Leu Ser Val Leu Gly Pro Pro Pro Val 
                85                  90                  95      


Thr Gly Glu Ser Tyr Trp Ala Tyr Leu Pro Lys Pro Pro Ile Leu His 
            100                 105                 110         


Pro Val Gly Trp Gly Ser Thr Asp Pro Ile Arg Val Leu Thr Asn Gln 
        115                 120                 125             


Thr Met Tyr Leu Gly Gly Ser Pro Asp Phe His Gly Phe Arg Asn Met 
    130                 135                 140                 


Ser Gly Asn Val His Phe Glu Gly Lys Ser Asp Thr Leu Pro Ile Cys 
145                 150                 155                 160 


Leu Ser Phe Ser Phe Ser Thr Pro Thr Gly Cys Phe Gln Val Asp Lys 
                165                 170                 175     


Gln Val Phe Leu Ser Asp Thr Pro Thr Val Asp Asn Asn Lys Pro Gly 
            180                 185                 190         


Gly Lys Gly Asp Lys Arg Arg Met Trp Glu Leu Trp Leu Thr Thr Leu 
        195                 200                 205             


Gly Asn Ser Gly Ala Asn Thr Lys Leu Val Pro Ile Lys Lys Lys Leu 
    210                 215                 220                 


Pro Pro Lys Tyr Pro His Cys Gln Ile Ala Phe Lys Lys Asp Ala Phe 
225                 230                 235                 240 


Trp Glu Gly Asp Glu Ser Ala Pro Pro Arg Trp Leu Pro Cys Ala Phe 
                245                 250                 255     


Pro Asp Gln Gly Val Ser Phe Ser Pro Lys Gly Ala Leu Gly Leu Leu 
            260                 265                 270         


Trp Asp Phe Ser Leu Pro Ser Pro Ser Val Asp Gln Ser Asp Gln Ile 
        275                 280                 285             


Lys Ser Lys Lys Asn Leu Phe Gly Asn Tyr Thr Pro Pro Val Asn Lys 
    290                 295                 300                 


Glu Val His Arg Trp Tyr Glu Ala Gly Trp Val Glu Pro Thr Trp Phe 
305                 310                 315                 320 


Trp Glu Asn Ser Pro Lys Asp Pro Asn Asp Arg Asp Phe Thr Ala Leu 
                325                 330                 335     


Val Pro His Thr Glu Leu Phe Arg Leu Val Ala Ala Ser Arg His Leu 
            340                 345                 350         


Ile Leu Lys Arg Pro Gly Phe Gln Glu His Glu Met Ile Pro Thr Ser 
        355                 360                 365             


Ala Cys Val Thr Tyr Pro Tyr Ala Ile Leu Leu Gly Leu Pro Gln Leu 
    370                 375                 380                 


Ile Asp Ile Glu Lys Arg Gly Ser Thr Phe His Ile Ser Cys Ser Ser 
385                 390                 395                 400 


Cys Arg Leu Thr Asn Cys Leu Asp Ser Ser Ala Tyr Asp Tyr Ala Ala 
                405                 410                 415     


Ile Ile Val Lys Arg Pro Pro Tyr Val Leu Leu Pro Val Asp Ile Gly 
            420                 425                 430         


Asp Glu Pro Trp Phe Asp Asp Ser Ala Ile Gln Thr Phe Arg Tyr Ala 
        435                 440                 445             


Thr Asp Leu Ile Arg Ala Lys Arg Phe Val Ala Ala Ile Ile Leu Gly 
    450                 455                 460                 


Ile Ser Ala Leu Ile Ala Ile Ile Thr Ser Phe Ala Val Ala Thr Thr 
465                 470                 475                 480 


Ala Leu Val Lys Glu Met Gln Thr Ala Thr Phe Val Asn Asn Leu His 
                485                 490                 495     


Arg Asn Val Thr Leu Ala Leu Ser Glu Gln Arg Ile Ile Asp Leu Lys 
            500                 505                 510         


Leu Glu Ala Arg Leu Asn Ala Leu Glu Glu Val Val Leu Glu Leu Gly 
        515                 520                 525             


Gln Asp Val Ala Asn Leu Lys Thr Arg Met Ser Thr Arg Cys His Ala 
    530                 535                 540                 


Asn Tyr Asp Phe Ile Cys Val Thr Pro Leu Pro Tyr Asn Ala Thr Glu 
545                 550                 555                 560 


Asn Trp Glu Arg Thr Arg Ala His Leu Leu Gly Ile Trp Asn Asp Asn 
                565                 570                 575     


Glu Ile Ser Tyr Asn Ile Gln Glu Leu Thr Asn Leu Ile Ser Asp Met 
            580                 585                 590         


Ser Lys Gln His Ile Asp Ala Val Asp Leu Ser Gly Leu Ala Gln Ser 
        595                 600                 605             


Phe Ala Asn Gly Val Lys Ala Leu Asn Pro Leu Asp Trp Thr Gln Tyr 
    610                 615                 620                 


Phe Ile Phe Ile Gly Val Gly Ala Leu Leu Leu Val Ile Val Leu Met 
625                 630                 635                 640 


Ile Phe Pro Ile Val Phe Gln Cys Leu Ala Lys Ser Leu Asp Gln Val 
                645                 650                 655     


Gln Ser Asp Leu Asn Val Leu Leu Leu Lys Lys Lys Lys Gly Gly Asn 
            660                 665                 670         


Ala Ala Pro Ala Ala Glu Met Val Glu Leu Pro Arg Val Ser Tyr Thr 
        675                 680                 685             


<210>  447
<211>  1467
<212>  DNA
<213>  Deltaretrovirus Human T-lymphotropic virus 1

<400>  447
atgggtaagt ttctcgccac tttgatttta ttcttccagt tctgccccct catcttcggt       60

gattacagcc ccagctgctg tactctcaca attggagtct cctcatacca ctctaaaccc      120

tgcaatcctg cccagccagt ttgttcgtgg accctcgacc tgctggccct ttcagcagat      180

caggccctac agcccccctg ccctaaccta gtaagttact ccagctacca tgccacctat      240

tccctatatc tattccctca ttggactaag aagccaaacc gaaatggcgg aggctattat      300

tcagcctctt attcagaccc ttgttcctta aagtgcccat acctggggtg ccaatcatgg      360

acctgcccct atacaggagc cgtctccagc ccctactgga agtttcaaca cgatgtcaat      420

tttactcaag aagtttcacg cctcaatatt aatctccatt tttcaaaatg cggttttccc      480

ttctcccttc tagtcgacgc tccaggatat gaccccatct ggttccttaa taccgaaccc      540

agccaactgc ctcccaccgc ccctcctcta ctcccccact ctaacctaga ccacatcctc      600

gagccctcta taccatggaa atcaaaactc ctgacccttg tccagttaac cctacaaagc      660

actaattata cttgcattgt ctgtatcgat cgtgccagcc tctccacttg gcacgtccta      720

tactctccca acgtctctgt tccatcctct tcttctaccc ccctccttta cccatcgtta      780

gcgcttccag ccccccacct gacgttacca tttaactgga cccactgctt tgacccccag      840

attcaagcta tagtctcctc cccctgtcat aactccctca tcctgccccc cttttccttg      900

tcacctgttc ccaccctagg atcccgctcc cgccgagcgg taccggtggc ggtctggctt      960

gtctccgccc tggccatggg agccggagtg gctggcggga ttaccggctc catgtccctc     1020

gcctcaggaa agagcctcct acatgaggtg gacaaagata tttcccagtt aactcaagca     1080

atagtcaaaa accacaaaaa tctactcaaa attgcgcagt atgctgccca gaacagacga     1140

ggccttgatc tcctgttctg ggagcaagga ggattatgca aagcattaca agaacagtgc     1200

cgttttccga atattaccaa ttcccatgtc ccaatactac aagaaagacc cccccttgag     1260

aatcgagtcc tgactggctg gggccttaac tgggaccttg gcctctcaca gtgggctcga     1320

gaggccttac aaactggaat cacccttgtt gcgctactcc ttcttgttat ccttgcagga     1380

ccatgcatcc tccgtcagct acgacacctc ccctcgcgcg tcagataccc ccattactct     1440

cttataaaac ctgagtcatc cctgtaa                                         1467


<210>  448
<211>  488
<212>  PRT
<213>  Deltaretrovirus Human T-lymphotropic virus 1

<400>  448

Met Gly Lys Phe Leu Ala Thr Leu Ile Leu Phe Phe Gln Phe Cys Pro 
1               5                   10                  15      


Leu Ile Phe Gly Asp Tyr Ser Pro Ser Cys Cys Thr Leu Thr Ile Gly 
            20                  25                  30          


Val Ser Ser Tyr His Ser Lys Pro Cys Asn Pro Ala Gln Pro Val Cys 
        35                  40                  45              


Ser Trp Thr Leu Asp Leu Leu Ala Leu Ser Ala Asp Gln Ala Leu Gln 
    50                  55                  60                  


Pro Pro Cys Pro Asn Leu Val Ser Tyr Ser Ser Tyr His Ala Thr Tyr 
65                  70                  75                  80  


Ser Leu Tyr Leu Phe Pro His Trp Thr Lys Lys Pro Asn Arg Asn Gly 
                85                  90                  95      


Gly Gly Tyr Tyr Ser Ala Ser Tyr Ser Asp Pro Cys Ser Leu Lys Cys 
            100                 105                 110         


Pro Tyr Leu Gly Cys Gln Ser Trp Thr Cys Pro Tyr Thr Gly Ala Val 
        115                 120                 125             


Ser Ser Pro Tyr Trp Lys Phe Gln His Asp Val Asn Phe Thr Gln Glu 
    130                 135                 140                 


Val Ser Arg Leu Asn Ile Asn Leu His Phe Ser Lys Cys Gly Phe Pro 
145                 150                 155                 160 


Phe Ser Leu Leu Val Asp Ala Pro Gly Tyr Asp Pro Ile Trp Phe Leu 
                165                 170                 175     


Asn Thr Glu Pro Ser Gln Leu Pro Pro Thr Ala Pro Pro Leu Leu Pro 
            180                 185                 190         


His Ser Asn Leu Asp His Ile Leu Glu Pro Ser Ile Pro Trp Lys Ser 
        195                 200                 205             


Lys Leu Leu Thr Leu Val Gln Leu Thr Leu Gln Ser Thr Asn Tyr Thr 
    210                 215                 220                 


Cys Ile Val Cys Ile Asp Arg Ala Ser Leu Ser Thr Trp His Val Leu 
225                 230                 235                 240 


Tyr Ser Pro Asn Val Ser Val Pro Ser Ser Ser Ser Thr Pro Leu Leu 
                245                 250                 255     


Tyr Pro Ser Leu Ala Leu Pro Ala Pro His Leu Thr Leu Pro Phe Asn 
            260                 265                 270         


Trp Thr His Cys Phe Asp Pro Gln Ile Gln Ala Ile Val Ser Ser Pro 
        275                 280                 285             


Cys His Asn Ser Leu Ile Leu Pro Pro Phe Ser Leu Ser Pro Val Pro 
    290                 295                 300                 


Thr Leu Gly Ser Arg Ser Arg Arg Ala Val Pro Val Ala Val Trp Leu 
305                 310                 315                 320 


Val Ser Ala Leu Ala Met Gly Ala Gly Val Ala Gly Gly Ile Thr Gly 
                325                 330                 335     


Ser Met Ser Leu Ala Ser Gly Lys Ser Leu Leu His Glu Val Asp Lys 
            340                 345                 350         


Asp Ile Ser Gln Leu Thr Gln Ala Ile Val Lys Asn His Lys Asn Leu 
        355                 360                 365             


Leu Lys Ile Ala Gln Tyr Ala Ala Gln Asn Arg Arg Gly Leu Asp Leu 
    370                 375                 380                 


Leu Phe Trp Glu Gln Gly Gly Leu Cys Lys Ala Leu Gln Glu Gln Cys 
385                 390                 395                 400 


Arg Phe Pro Asn Ile Thr Asn Ser His Val Pro Ile Leu Gln Glu Arg 
                405                 410                 415     


Pro Pro Leu Glu Asn Arg Val Leu Thr Gly Trp Gly Leu Asn Trp Asp 
            420                 425                 430         


Leu Gly Leu Ser Gln Trp Ala Arg Glu Ala Leu Gln Thr Gly Ile Thr 
        435                 440                 445             


Leu Val Ala Leu Leu Leu Leu Val Ile Leu Ala Gly Pro Cys Ile Leu 
    450                 455                 460                 


Arg Gln Leu Arg His Leu Pro Ser Arg Val Arg Tyr Pro His Tyr Ser 
465                 470                 475                 480 


Leu Ile Lys Pro Glu Ser Ser Leu 
                485             


<210>  449
<211>  1698
<212>  DNA
<213>  Unknown

<220>  
<223>  RD114 Endogenous Feline Retrovirus

<400>  449
atgaaactcc caacaggaat ggtcatttta tgtagcctaa taatagttcg ggcagggttt       60

gacgaccccc gcaaggctat cgcattagta caaaaacaac atggtaaacc atgcgaatgc      120

agcggagggc aggtatccga ggccccaccg aactccatcc aacaggtaac ttgcccaggc      180

aagacggcct acttaatgac caaccaaaaa tggaaatgca gagtcactcc aaaaaatctc      240

acccctagcg ggggagaact ccagaactgc ccctgtaaca ctttccagga ctcgatgcac      300

agttcttgtt atactgaata ccggcaatgc agggcgaata ataagacata ctacacggcc      360

accttgctta aaatacggtc tgggagcctc aacgaggtac agatattaca aaaccccaat      420

cagctcctac agtccccttg taggggctct ataaatcagc ccgtttgctg gagtgccaca      480

gcccccatcc atatctccga tggtggagga cccctcgata ctaagagagt gtggacagtc      540

caaaaaaggc tagaacaaat tcataaggct atgcatcctg aacttcaata ccacccctta      600

gccctgccca aagtcagaga tgaccttagc cttgatgcac ggacttttga tatcctgaat      660

accactttta ggttactcca gatgtccaat tttagccttg cccaagattg ttggctctgt      720

ttaaaactag gtacccctac ccctcttgcg atacccactc cctctttaac ctactcccta      780

gcagactccc tagcgaatgc ctcctgtcag attatacctc ccctcttggt tcaaccgatg      840

cagttctcca actcgtcctg tttatcttcc cctttcatta acgatacgga acaaatagac      900

ttaggtgcag tcacctttac taactgcacc tctgtagcca atgtcagtag tcctttatgt      960

gccctaaacg ggtcagtctt cctctgtgga aataacatgg catacaccta tttaccccaa     1020

aactggacag gactttgcgt ccaagcctcc ctcctccccg acattgacat catcccgggg     1080

gatgagccag tccccattcc tgccattgat cattatatac atagacctaa acgagctgta     1140

cagttcatcc ctttactagc tggactggga atcaccgcag cattcaccac cggagctaca     1200

ggcctaggtg tctccgtcac ccagtataca aaattatccc atcagttaat atctgatgtc     1260

caagtcttat ccggtaccat acaagattta caagaccagg tagactcgtt agctgaagta     1320

gttctccaaa ataggagggg actggaccta ctaacggcag aacaaggagg aatttgttta     1380

gccttacaag aaaaatgctg tttttatgct aacaagtcag gaattgtgag aaacaaaata     1440

agaaccctac aagaagaatt acaaaaacgc agggaaagcc tggcatccaa ccctctctgg     1500

accgggctgc agggctttct tccgtacctc ctacctctcc tgggacccct actcaccctc     1560

ctactcatac taaccattgg gccatgcgtt ttcagtcgcc tcatggcctt cattaatgat     1620

agacttaatg ttgtacatgc catggtgctg gcccagcaat accaagcact caaagctgag     1680

gaagaagctc aggattga                                                   1698


<210>  450
<211>  565
<212>  PRT
<213>  Unknown

<220>  
<223>  RD114 Endogenous Feline Retrovirus

<400>  450

Met Lys Leu Pro Thr Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      


Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          


Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              


Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Asn Leu 
65                  70                  75                  80  


Thr Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln 
                85                  90                  95      


Asp Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Ala 
            100                 105                 110         


Asn Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly 
        115                 120                 125             


Ser Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln 
    130                 135                 140                 


Ser Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr 
145                 150                 155                 160 


Ala Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg 
                165                 170                 175     


Val Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met His 
            180                 185                 190         


Pro Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp 
        195                 200                 205             


Leu Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe Arg 
    210                 215                 220                 


Leu Leu Gln Met Ser Asn Phe Ser Leu Ala Gln Asp Cys Trp Leu Cys 
225                 230                 235                 240 


Leu Lys Leu Gly Thr Pro Thr Pro Leu Ala Ile Pro Thr Pro Ser Leu 
                245                 250                 255     


Thr Tyr Ser Leu Ala Asp Ser Leu Ala Asn Ala Ser Cys Gln Ile Ile 
            260                 265                 270         


Pro Pro Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu 
        275                 280                 285             


Ser Ser Pro Phe Ile Asn Asp Thr Glu Gln Ile Asp Leu Gly Ala Val 
    290                 295                 300                 


Thr Phe Thr Asn Cys Thr Ser Val Ala Asn Val Ser Ser Pro Leu Cys 
305                 310                 315                 320 


Ala Leu Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr 
                325                 330                 335     


Tyr Leu Pro Gln Asn Trp Thr Gly Leu Cys Val Gln Ala Ser Leu Leu 
            340                 345                 350         


Pro Asp Ile Asp Ile Ile Pro Gly Asp Glu Pro Val Pro Ile Pro Ala 
        355                 360                 365             


Ile Asp His Tyr Ile His Arg Pro Lys Arg Ala Val Gln Phe Ile Pro 
    370                 375                 380                 


Leu Leu Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr 
385                 390                 395                 400 


Gly Leu Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser His Gln Leu 
                405                 410                 415     


Ile Ser Asp Val Gln Val Leu Ser Gly Thr Ile Gln Asp Leu Gln Asp 
            420                 425                 430         


Gln Val Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu 
        435                 440                 445             


Asp Leu Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu 
    450                 455                 460                 


Lys Cys Cys Phe Tyr Ala Asn Lys Ser Gly Ile Val Arg Asn Lys Ile 
465                 470                 475                 480 


Arg Thr Leu Gln Glu Glu Leu Gln Lys Arg Arg Glu Ser Leu Ala Ser 
                485                 490                 495     


Asn Pro Leu Trp Thr Gly Leu Gln Gly Phe Leu Pro Tyr Leu Leu Pro 
            500                 505                 510         


Leu Leu Gly Pro Leu Leu Thr Leu Leu Leu Ile Leu Thr Ile Gly Pro 
        515                 520                 525             


Cys Val Phe Ser Arg Leu Met Ala Phe Ile Asn Asp Arg Leu Asn Val 
    530                 535                 540                 


Val His Ala Met Val Leu Ala Gln Gln Tyr Gln Ala Leu Lys Ala Glu 
545                 550                 555                 560 


Glu Glu Ala Gln Asp 
                565 


<210>  451
<211>  2058
<212>  DNA
<213>  Gammaretrovirus Gibbon ape leukemia virus

<400>  451
atggtattgc tgcctgggtc catgcttctc acctcaagcc tgcaccacct tcggcaccag       60

atgagtcctg ggagttggaa aagactgatc atcctcttaa gctgcgtatt cggcggcggc      120

ggaacgagtc tgcaaaataa gaacccccac cagcctatga ccctcacctg gcaggtactg      180

tcccaaactg gagacgttgt ctgggataca aaggcagtcc agcccccttg gacttggtgg      240

cccacactta aacctgatat atgtgccttg gcggctggtc ttgagtcctg ggatatcccg      300

ggaaccgatg tctcgtcctc taaacgagtc agacctccgg actcagacta tactgccgct      360

tataaacaaa tcacctgggg agccataggg tgcagctacc ctcgggctag gaccagaatg      420

gcaagctcca ccttctacgt atgtccccgg gatggccgga ccccttcaga agctagaagg      480

tgcggggggc tagaatccct atactgtaaa gaatggaatt gtgaaaccac agggaccggt      540

tattggctac ccaagtcctc aaaagacctc ataacgggta gatgggatca aaatagcaaa      600

tgggatcaaa aatttcaaaa gtgtcaccag accggctggt gtaaccccct taaaatagat      660

ttcacagaca caggaaaatc ctccagggat tggatagtag gaaaaacctg gggattaaga      720

ttctatgtgc atggacatcc aggcgtccag ttcaccattc gcttaaaaat caccagcatg      780

acagctgtgg cagtcggccc cgatcccgtc cttgtggaac aaggacctcc cagaagggcc      840

ctcgctctcc cacctcctct ccccccaagg gaagcgccac cgccacctct ccccgactcc      900

aactccacaa ccctggcgac tagtgcacaa actcccacgg tgggaaaaac aattgttacc      960

ctaaacactc cgcctcccac cacaggcgac agactcttta acctcgtgca gggggccttc     1020

ctaaccctga atgctaccaa cccaggggcc actaagtcat gctggctttg tttggccatg     1080

ggtcccccct attatgaagc aataacctca ttgggggagg tcgcttattc caccagccag     1140

gaccggtgcc actggggaac ccaaggaaag cttaccctca ctgaggtctc aggacacggg     1200

ttatgcatag gaaaggtgcc cttcacccat cagcatctct gcaatcagac cctatccatc     1260

aattcctccg agggccatca gtatctgctc ccctccaatc atagctggtg ggcttgcagc     1320

actggcctca ccccttgcct ctctacctca gtttttaatc agagtcgaga tttctgtatc     1380

caggtccagc tgatccctcg catctattac tatcctgaag aagttttgtt acaggcctat     1440

gacgattctc accccaggcc taaaagagaa gctgtctcac ttaccctagc tgttttactg     1500

gggttgggga tcacggcggg tataggtact ggttcaaccg ccttaattaa aggacccata     1560

gacctccaac aaggcctgac cagcctccag atcgccatag atgctgacct ccgggccctc     1620

caggactcag tcagcaagct ggaggactca ctgacctccc tgtccgaggt agtactccaa     1680

aataggagag gccttgactt gctgtttcta aaggaaggag gcctctgtgc ggccctaaaa     1740

gaagagtgct gtttttatat agaccactca ggtgcagtac gagactccat gaaaaaactc     1800

aaagaaaaac tagataaaag acagttagag cgccagaaaa accaaaactg gtatgaaggg     1860

tggttcaata actccccttg gttcactacc ctactatcaa ccattgccgg gcccctgtta     1920

ctcctccttc tattgctcat cctcgggccc tgcatcatca ataagttagt tcaattcatc     1980

aatgatagag taagtgcagt taaaattttg gtccttagga caaaatatca ggccctagat     2040

aacgaagata acctttaa                                                   2058


<210>  452
<211>  685
<212>  PRT
<213>  Gammaretrovirus Gibbon ape leukemia virus

<400>  452

Met Val Leu Leu Pro Gly Ser Met Leu Leu Thr Ser Ser Leu His His 
1               5                   10                  15      


Leu Arg His Gln Met Ser Pro Gly Ser Trp Lys Arg Leu Ile Ile Leu 
            20                  25                  30          


Leu Ser Cys Val Phe Gly Gly Gly Gly Thr Ser Leu Gln Asn Lys Asn 
        35                  40                  45              


Pro His Gln Pro Met Thr Leu Thr Trp Gln Val Leu Ser Gln Thr Gly 
    50                  55                  60                  


Asp Val Val Trp Asp Thr Lys Ala Val Gln Pro Pro Trp Thr Trp Trp 
65                  70                  75                  80  


Pro Thr Leu Lys Pro Asp Ile Cys Ala Leu Ala Ala Gly Leu Glu Ser 
                85                  90                  95      


Trp Asp Ile Pro Gly Thr Asp Val Ser Ser Ser Lys Arg Val Arg Pro 
            100                 105                 110         


Pro Asp Ser Asp Tyr Thr Ala Ala Tyr Lys Gln Ile Thr Trp Gly Ala 
        115                 120                 125             


Ile Gly Cys Ser Tyr Pro Arg Ala Arg Thr Arg Met Ala Ser Ser Thr 
    130                 135                 140                 


Phe Tyr Val Cys Pro Arg Asp Gly Arg Thr Pro Ser Glu Ala Arg Arg 
145                 150                 155                 160 


Cys Gly Gly Leu Glu Ser Leu Tyr Cys Lys Glu Trp Asn Cys Glu Thr 
                165                 170                 175     


Thr Gly Thr Gly Tyr Trp Leu Pro Lys Ser Ser Lys Asp Leu Ile Thr 
            180                 185                 190         


Gly Arg Trp Asp Gln Asn Ser Lys Trp Asp Gln Lys Phe Gln Lys Cys 
        195                 200                 205             


His Gln Thr Gly Trp Cys Asn Pro Leu Lys Ile Asp Phe Thr Asp Thr 
    210                 215                 220                 


Gly Lys Ser Ser Arg Asp Trp Ile Val Gly Lys Thr Trp Gly Leu Arg 
225                 230                 235                 240 


Phe Tyr Val His Gly His Pro Gly Val Gln Phe Thr Ile Arg Leu Lys 
                245                 250                 255     


Ile Thr Ser Met Thr Ala Val Ala Val Gly Pro Asp Pro Val Leu Val 
            260                 265                 270         


Glu Gln Gly Pro Pro Arg Arg Ala Leu Ala Leu Pro Pro Pro Leu Pro 
        275                 280                 285             


Pro Arg Glu Ala Pro Pro Pro Pro Leu Pro Asp Ser Asn Ser Thr Thr 
    290                 295                 300                 


Leu Ala Thr Ser Ala Gln Thr Pro Thr Val Gly Lys Thr Ile Val Thr 
305                 310                 315                 320 


Leu Asn Thr Pro Pro Pro Thr Thr Gly Asp Arg Leu Phe Asn Leu Val 
                325                 330                 335     


Gln Gly Ala Phe Leu Thr Leu Asn Ala Thr Asn Pro Gly Ala Thr Lys 
            340                 345                 350         


Ser Cys Trp Leu Cys Leu Ala Met Gly Pro Pro Tyr Tyr Glu Ala Ile 
        355                 360                 365             


Thr Ser Leu Gly Glu Val Ala Tyr Ser Thr Ser Gln Asp Arg Cys His 
    370                 375                 380                 


Trp Gly Thr Gln Gly Lys Leu Thr Leu Thr Glu Val Ser Gly His Gly 
385                 390                 395                 400 


Leu Cys Ile Gly Lys Val Pro Phe Thr His Gln His Leu Cys Asn Gln 
                405                 410                 415     


Thr Leu Ser Ile Asn Ser Ser Glu Gly His Gln Tyr Leu Leu Pro Ser 
            420                 425                 430         


Asn His Ser Trp Trp Ala Cys Ser Thr Gly Leu Thr Pro Cys Leu Ser 
        435                 440                 445             


Thr Ser Val Phe Asn Gln Ser Arg Asp Phe Cys Ile Gln Val Gln Leu 
    450                 455                 460                 


Ile Pro Arg Ile Tyr Tyr Tyr Pro Glu Glu Val Leu Leu Gln Ala Tyr 
465                 470                 475                 480 


Asp Asp Ser His Pro Arg Pro Lys Arg Glu Ala Val Ser Leu Thr Leu 
                485                 490                 495     


Ala Val Leu Leu Gly Leu Gly Ile Thr Ala Gly Ile Gly Thr Gly Ser 
            500                 505                 510         


Thr Ala Leu Ile Lys Gly Pro Ile Asp Leu Gln Gln Gly Leu Thr Ser 
        515                 520                 525             


Leu Gln Ile Ala Ile Asp Ala Asp Leu Arg Ala Leu Gln Asp Ser Val 
    530                 535                 540                 


Ser Lys Leu Glu Asp Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln 
545                 550                 555                 560 


Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu Cys 
                565                 570                 575     


Ala Ala Leu Lys Glu Glu Cys Cys Phe Tyr Ile Asp His Ser Gly Ala 
            580                 585                 590         


Val Arg Asp Ser Met Lys Lys Leu Lys Glu Lys Leu Asp Lys Arg Gln 
        595                 600                 605             


Leu Glu Arg Gln Lys Asn Gln Asn Trp Tyr Glu Gly Trp Phe Asn Asn 
    610                 615                 620                 


Ser Pro Trp Phe Thr Thr Leu Leu Ser Thr Ile Ala Gly Pro Leu Leu 
625                 630                 635                 640 


Leu Leu Leu Leu Leu Leu Ile Leu Gly Pro Cys Ile Ile Asn Lys Leu 
                645                 650                 655     


Val Gln Phe Ile Asn Asp Arg Val Ser Ala Val Lys Ile Leu Val Leu 
            660                 665                 670         


Arg Thr Lys Tyr Gln Ala Leu Asp Asn Glu Asp Asn Leu 
        675                 680                 685 


<210>  453
<211>  1998
<212>  DNA
<213>  Gammaretrovirus Moloney Murine leukemia virus

<400>  453
atggcgcgtt caacgctctc aaaacccctt aaaaataagg ttaacccgcg aggcccccta       60

atccccttaa ttcttctgat gctcagaggg gtcagtactg cttcgcccgg ctccagtcct      120

catcaagtct ataatatcac ctgggaggta accaatggag atcgggagac ggtatgggca      180

acttctggca accaccctct gtggacctgg tggcctgacc ttaccccaga tttatgtatg      240

ttagcccacc atggaccatc ttattggggg ctagaatatc aatccccttt ttcttctccc      300

ccggggcccc cttgttgctc agggggcagc agcccaggct gttccagaga ctgcgaagaa      360

cctttaacct ccctcacccc tcggtgcaac actgcctgga acagactcaa gctagaccag      420

acaactcata aatcaaatga gggattttat gtttgccccg ggccccaccg cccccgagaa      480

tccaagtcat gtgggggtcc agactccttc tactgtgcct attggggctg tgagacaacc      540

ggtagagctt actggaagcc ctcctcatca tgggatttca tcacagtaaa caacaatctc      600

acctctgacc aggctgtcca ggtatgcaaa gataataagt ggtgcaaccc cttagttatt      660

cggtttacag acgccgggag acgggttact tcctggacca caggacatta ctggggctta      720

cgtttgtatg tctccggaca agatccaggg cttacatttg ggatccgact cagataccaa      780

aatctaggac cccgcgtccc aatagggcca aaccccgttc tggcagacca acagccactc      840

tccaagccca aacctgttaa gtcgccttca gtcaccaaac cacccagtgg gactcctctc      900

tcccctaccc aacttccacc ggcgggaacg gaaaataggc tgctaaactt agtagacgga      960

gcctaccaag ccctcaacct caccagtcct gacaaaaccc aagagtgctg gttgtgtcta     1020

gtagcgggac ccccctacta cgaaggggtt gccgtcctgg gtacctactc caaccatacc     1080

tctgctccag ccaactgctc cgtggcctcc caacacaagt tgaccctgtc cgaagtgacc     1140

ggacagggac tctgcatagg agcagttccc aaaacacatc aggccctatg taataccacc     1200

cagacaagca gtcgagggtc ctattatcta gttgccccta caggtaccat gtgggcttgt     1260

agtaccgggc ttactccatg catctccacc accatactga accttaccac tgattattgt     1320

gttcttgtcg aactctggcc aagagtcacc tatcattccc ccagctatgt ttacggcctg     1380

tttgagagat ccaaccgaca caaaagagaa ccggtgtcgt taaccctggc cctattattg     1440

ggtggactaa ccatgggggg aattgccgct ggaataggaa cagggactac tgctctaatg     1500

gccactcagc aattccagca gctccaagcc gcagtacagg atgatctcag ggaggttgaa     1560

aaatcaatct ctaacctaga aaagtctctc acttccctgt ctgaagttgt cctacagaat     1620

cgaaggggcc tagacttgtt atttctaaaa gaaggagggc tgtgtgctgc tctaaaagaa     1680

gaatgttgct tctatgcgga ccacacagga ctagtgagag acagcatggc caaattgaga     1740

gagaggctta atcagagaca gaaactgttt gagtcaactc aaggatggtt tgagggactg     1800

tttaacagat ccccttggtt taccaccttg atatctacca ttatgggacc cctcattgta     1860

ctcctaatga ttttgctctt cggaccctgc attcttaatc gattagtcca atttgttaaa     1920

gacaggatat cagtggtcca ggctctagtt ttgactcaac aatatcacca gctgaagcct     1980

atagagtacg agccatag                                                   1998


<210>  454
<211>  665
<212>  PRT
<213>  Gammaretrovirus Moloney Murine leukemia virus

<400>  454

Met Ala Arg Ser Thr Leu Ser Lys Pro Leu Lys Asn Lys Val Asn Pro 
1               5                   10                  15      


Arg Gly Pro Leu Ile Pro Leu Ile Leu Leu Met Leu Arg Gly Val Ser 
            20                  25                  30          


Thr Ala Ser Pro Gly Ser Ser Pro His Gln Val Tyr Asn Ile Thr Trp 
        35                  40                  45              


Glu Val Thr Asn Gly Asp Arg Glu Thr Val Trp Ala Thr Ser Gly Asn 
    50                  55                  60                  


His Pro Leu Trp Thr Trp Trp Pro Asp Leu Thr Pro Asp Leu Cys Met 
65                  70                  75                  80  


Leu Ala His His Gly Pro Ser Tyr Trp Gly Leu Glu Tyr Gln Ser Pro 
                85                  90                  95      


Phe Ser Ser Pro Pro Gly Pro Pro Cys Cys Ser Gly Gly Ser Ser Pro 
            100                 105                 110         


Gly Cys Ser Arg Asp Cys Glu Glu Pro Leu Thr Ser Leu Thr Pro Arg 
        115                 120                 125             


Cys Asn Thr Ala Trp Asn Arg Leu Lys Leu Asp Gln Thr Thr His Lys 
    130                 135                 140                 


Ser Asn Glu Gly Phe Tyr Val Cys Pro Gly Pro His Arg Pro Arg Glu 
145                 150                 155                 160 


Ser Lys Ser Cys Gly Gly Pro Asp Ser Phe Tyr Cys Ala Tyr Trp Gly 
                165                 170                 175     


Cys Glu Thr Thr Gly Arg Ala Tyr Trp Lys Pro Ser Ser Ser Trp Asp 
            180                 185                 190         


Phe Ile Thr Val Asn Asn Asn Leu Thr Ser Asp Gln Ala Val Gln Val 
        195                 200                 205             


Cys Lys Asp Asn Lys Trp Cys Asn Pro Leu Val Ile Arg Phe Thr Asp 
    210                 215                 220                 


Ala Gly Arg Arg Val Thr Ser Trp Thr Thr Gly His Tyr Trp Gly Leu 
225                 230                 235                 240 


Arg Leu Tyr Val Ser Gly Gln Asp Pro Gly Leu Thr Phe Gly Ile Arg 
                245                 250                 255     


Leu Arg Tyr Gln Asn Leu Gly Pro Arg Val Pro Ile Gly Pro Asn Pro 
            260                 265                 270         


Val Leu Ala Asp Gln Gln Pro Leu Ser Lys Pro Lys Pro Val Lys Ser 
        275                 280                 285             


Pro Ser Val Thr Lys Pro Pro Ser Gly Thr Pro Leu Ser Pro Thr Gln 
    290                 295                 300                 


Leu Pro Pro Ala Gly Thr Glu Asn Arg Leu Leu Asn Leu Val Asp Gly 
305                 310                 315                 320 


Ala Tyr Gln Ala Leu Asn Leu Thr Ser Pro Asp Lys Thr Gln Glu Cys 
                325                 330                 335     


Trp Leu Cys Leu Val Ala Gly Pro Pro Tyr Tyr Glu Gly Val Ala Val 
            340                 345                 350         


Leu Gly Thr Tyr Ser Asn His Thr Ser Ala Pro Ala Asn Cys Ser Val 
        355                 360                 365             


Ala Ser Gln His Lys Leu Thr Leu Ser Glu Val Thr Gly Gln Gly Leu 
    370                 375                 380                 


Cys Ile Gly Ala Val Pro Lys Thr His Gln Ala Leu Cys Asn Thr Thr 
385                 390                 395                 400 


Gln Thr Ser Ser Arg Gly Ser Tyr Tyr Leu Val Ala Pro Thr Gly Thr 
                405                 410                 415     


Met Trp Ala Cys Ser Thr Gly Leu Thr Pro Cys Ile Ser Thr Thr Ile 
            420                 425                 430         


Leu Asn Leu Thr Thr Asp Tyr Cys Val Leu Val Glu Leu Trp Pro Arg 
        435                 440                 445             


Val Thr Tyr His Ser Pro Ser Tyr Val Tyr Gly Leu Phe Glu Arg Ser 
    450                 455                 460                 


Asn Arg His Lys Arg Glu Pro Val Ser Leu Thr Leu Ala Leu Leu Leu 
465                 470                 475                 480 


Gly Gly Leu Thr Met Gly Gly Ile Ala Ala Gly Ile Gly Thr Gly Thr 
                485                 490                 495     


Thr Ala Leu Met Ala Thr Gln Gln Phe Gln Gln Leu Gln Ala Ala Val 
            500                 505                 510         


Gln Asp Asp Leu Arg Glu Val Glu Lys Ser Ile Ser Asn Leu Glu Lys 
        515                 520                 525             


Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg Arg Gly Leu 
    530                 535                 540                 


Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu Cys Ala Ala Leu Lys Glu 
545                 550                 555                 560 


Glu Cys Cys Phe Tyr Ala Asp His Thr Gly Leu Val Arg Asp Ser Met 
                565                 570                 575     


Ala Lys Leu Arg Glu Arg Leu Asn Gln Arg Gln Lys Leu Phe Glu Ser 
            580                 585                 590         


Thr Gln Gly Trp Phe Glu Gly Leu Phe Asn Arg Ser Pro Trp Phe Thr 
        595                 600                 605             


Thr Leu Ile Ser Thr Ile Met Gly Pro Leu Ile Val Leu Leu Met Ile 
    610                 615                 620                 


Leu Leu Phe Gly Pro Cys Ile Leu Asn Arg Leu Val Gln Phe Val Lys 
625                 630                 635                 640 


Asp Arg Ile Ser Val Val Gln Ala Leu Val Leu Thr Gln Gln Tyr His 
                645                 650                 655     


Gln Leu Lys Pro Ile Glu Tyr Glu Pro 
            660                 665 


<210>  455
<211>  1692
<212>  DNA
<213>  Gammaretrovirus Baboon Endogenous Virus

<400>  455
atgggattca caacaaagat aatcttctta tacaacctag tactggtcta cgcggggttt       60

gacgaccctc gcaaagccat agaactagta caaaagcgat atggccgacc atgcgattgc      120

agcggaggac aagtgtccga gcccccgtca gacagggtca gtcaagtgac ttgctcaggc      180

aagacagctt acttaatgcc cgaccaaaga tggaaatgta agtcaattcc aaaagacacc      240

tccccaagcg ggccactcca agagtgcccc tgtaattctt accagtcctc agtacacagt      300

tcttgttata cctcatacca acaatgcaga tcaggcaata agacatatta tacggctact      360

ctgctaaaaa cacaaactgg gggcaccagt gatgtacaag tattaggatc caccaacaaa      420

cttatacaat ctccctgtaa tggcataaaa gggcagtcta tttgctggag cactacagct      480

cctatccacg tctctgatgg aggaggtcca ttagacacca caagaattaa aagtgttcag      540

agaaaactgg aagaaattca taaagcccta tatcctgaac ttcagtatca ccctttggcc      600

atacctaagg ttagagataa cctcatggtc gatgcccaga ctttaaacat tctcaatgcc      660

acttacaact tactcctaat gtccaacacg agcctagtgg acgactgttg gctttgttta      720

aaattaggtc cccctactcc cctcgcaata cctaacttcc tattatccta cgtgactcgc      780

tcctcggata atatctcttg tttaataatt cccccccttc tagttcaacc gatgcagttt      840

tccaattcat cttgcctctt ttccccctcc tacaacagta cagaagaaat agatctaggc      900

catgttgcct tcagcaactg tacctccata accaatgtca ccggtcccat atgcgctgta      960

aatggttcgg tctttctctg tggcaataac atggcataca cttatctacc cacgaactgg     1020

acggggcttt gcgtcctagc aactctcctc cccgacattg acatcattcc cggagatgaa     1080

ccggtcccca tccctgctat tgatcatttt atatatagac ctaaacgggc catacagttt     1140

attcctttac tagcagggct agggatcacc gcagccttca caacaggagc tacaggccta     1200

ggtgtctctg tgacccaata tacaaaatta tctaatcagc taatttctga tgtacaaatc     1260

ttatctagca ccatacaaga tctgcaagat caagtagact cattagccga agtggttctc     1320

cagaacagaa gggggctaga tctacttaca gcagaacaag gaggaatctg tttagccctg     1380

caagaaaaat gctgctttta tgttaacaag tcagggattg tgagagacaa aataaaaacc     1440

ttacaagaag aactagaaag acgtagaaaa gatctagctt ccaacccact ttggactggg     1500

cttcaagggc tcctccctta cctcctgccc tttcttggcc ctctacttac cctcctgctc     1560

ttactcacca ttgggccgtg catttttaac cgtctaaccg cttttattaa tgataagtta     1620

aacataatac acgctatggt gctaacccaa cagtatcagg tgctcagaac cgatgaagaa     1680

gctcaagatt ga                                                         1692


<210>  456
<211>  563
<212>  PRT
<213>  Gammaretrovirus Baboon Endogenous Virus

<400>  456

Met Gly Phe Thr Thr Lys Ile Ile Phe Leu Tyr Asn Leu Val Leu Val 
1               5                   10                  15      


Tyr Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Glu Leu Val Gln Lys 
            20                  25                  30          


Arg Tyr Gly Arg Pro Cys Asp Cys Ser Gly Gly Gln Val Ser Glu Pro 
        35                  40                  45              


Pro Ser Asp Arg Val Ser Gln Val Thr Cys Ser Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Pro Asp Gln Arg Trp Lys Cys Lys Ser Ile Pro Lys Asp Thr 
65                  70                  75                  80  


Ser Pro Ser Gly Pro Leu Gln Glu Cys Pro Cys Asn Ser Tyr Gln Ser 
                85                  90                  95      


Ser Val His Ser Ser Cys Tyr Thr Ser Tyr Gln Gln Cys Arg Ser Gly 
            100                 105                 110         


Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Thr Gln Thr Gly Gly 
        115                 120                 125             


Thr Ser Asp Val Gln Val Leu Gly Ser Thr Asn Lys Leu Ile Gln Ser 
    130                 135                 140                 


Pro Cys Asn Gly Ile Lys Gly Gln Ser Ile Cys Trp Ser Thr Thr Ala 
145                 150                 155                 160 


Pro Ile His Val Ser Asp Gly Gly Gly Pro Leu Asp Thr Thr Arg Ile 
                165                 170                 175     


Lys Ser Val Gln Arg Lys Leu Glu Glu Ile His Lys Ala Leu Tyr Pro 
            180                 185                 190         


Glu Leu Gln Tyr His Pro Leu Ala Ile Pro Lys Val Arg Asp Asn Leu 
        195                 200                 205             


Met Val Asp Ala Gln Thr Leu Asn Ile Leu Asn Ala Thr Tyr Asn Leu 
    210                 215                 220                 


Leu Leu Met Ser Asn Thr Ser Leu Val Asp Asp Cys Trp Leu Cys Leu 
225                 230                 235                 240 


Lys Leu Gly Pro Pro Thr Pro Leu Ala Ile Pro Asn Phe Leu Leu Ser 
                245                 250                 255     


Tyr Val Thr Arg Ser Ser Asp Asn Ile Ser Cys Leu Ile Ile Pro Pro 
            260                 265                 270         


Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu Phe Ser 
        275                 280                 285             


Pro Ser Tyr Asn Ser Thr Glu Glu Ile Asp Leu Gly His Val Ala Phe 
    290                 295                 300                 


Ser Asn Cys Thr Ser Ile Thr Asn Val Thr Gly Pro Ile Cys Ala Val 
305                 310                 315                 320 


Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr Tyr Leu 
                325                 330                 335     


Pro Thr Asn Trp Thr Gly Leu Cys Val Leu Ala Thr Leu Leu Pro Asp 
            340                 345                 350         


Ile Asp Ile Ile Pro Gly Asp Glu Pro Val Pro Ile Pro Ala Ile Asp 
        355                 360                 365             


His Phe Ile Tyr Arg Pro Lys Arg Ala Ile Gln Phe Ile Pro Leu Leu 
    370                 375                 380                 


Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr Gly Leu 
385                 390                 395                 400 


Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser Asn Gln Leu Ile Ser 
                405                 410                 415     


Asp Val Gln Ile Leu Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val 
            420                 425                 430         


Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu 
        435                 440                 445             


Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu Lys Cys 
    450                 455                 460                 


Cys Phe Tyr Val Asn Lys Ser Gly Ile Val Arg Asp Lys Ile Lys Thr 
465                 470                 475                 480 


Leu Gln Glu Glu Leu Glu Arg Arg Arg Lys Asp Leu Ala Ser Asn Pro 
                485                 490                 495     


Leu Trp Thr Gly Leu Gln Gly Leu Leu Pro Tyr Leu Leu Pro Phe Leu 
            500                 505                 510         


Gly Pro Leu Leu Thr Leu Leu Leu Leu Leu Thr Ile Gly Pro Cys Ile 
        515                 520                 525             


Phe Asn Arg Leu Thr Ala Phe Ile Asn Asp Lys Leu Asn Ile Ile His 
    530                 535                 540                 


Ala Met Val Leu Thr Gln Gln Tyr Gln Val Leu Arg Thr Asp Glu Glu 
545                 550                 555                 560 


Ala Gln Asp 
            


<210>  457
<211>  2958
<212>  DNA
<213>  Spumavirus Human Foamy Virus

<400>  457
atgacactgc aacaatggat catttggaaa aaaatgaata aagcgcatga ggcacttcaa       60

aatacaacaa ctgtgactga acagcagaag gaacaaatta tactggacat tcaaaatgaa      120

gaagtacaac caactaggag agataaattt agatatctgc tttatacttg ttgtgctact      180

agctcaagag tattggcctg gatgttttta gtttgtatat tgttaatcat tgttttggtt      240

tcatgctttg tgactatatc cagaatacaa tggaataagg atattcaggt attaggacct      300

gtaatagact ggaatgttac tcaaagagct gtttatcaac ccttacagac tagaaggatt      360

gcacgttccc ttagaatgca gcatcctgtt ccaaaatatg tggaggtaaa tatgactagt      420

attccacaag gtgtatacta tgaaccccat ccggaaccca tagtggtgaa ggagagggtc      480

ctaggtcttt ctcaaattct gatgattaat tcagaaaaca ttgctaataa tgctaatttg      540

acacaagaag taaagaagtt gttaactgaa atggttaatg aagaaatgca aagtttgtca      600

gatgtaatga ttgactttga aattccttta ggagaccctc gtgatcaaga acaatatata      660

catagaaaat gctatcaaga atttgcaaat tgttatttag taaaatataa agaacccaaa      720

ccgtggccta aggagggcct tatagctgat caatgcccat taccaggtta ccatgctgga      780

ttaacctata atagacagtc tatttgggat tactatatta aagtggagag tattagacct      840

gcaaattgga caacaaagag taaatatgga caagctagac taggaagttt ttatattcct      900

agcagcctga gacaaatcaa tgttagtcat gtactattct gtagtgatca attatattct      960

aaatggtata atatagaaaa taccatagaa caaaacgagc ggtttctgct taataaacta     1020

aataacctta catctggaac ctcagtattg aagaaaagag ctcttccgaa ggattggagt     1080

tctcaaggta aaaatgctct gtttagagaa atcaatgtgt tagatatctg cagtaaacct     1140

gaatctgtaa tactattgaa tacttcatac tattccttct ctttatggga aggagattgt     1200

aattttacta aagatatgat ttctcagttg gttccagaat gtgatggatt ttataacaat     1260

tctaagtgga tgcatatgca tccatatgct tgtagattct ggagaagtaa gaagaatgaa     1320

aaagaagaaa ctaaatgtag agatggggaa actaagagat gtctgtatta tcctttatgg     1380

gacagtcccg aatctacata tgattttggt tatttagcat accaaaagaa ttttccttcc     1440

cctatctgta tagaacaaca gaaaattaga gatcaagatt atgaagtcta ttctttgtat     1500

caagaacgca aaatagcttc taaagcatat ggaattgata cagttttatt ctctctaaag     1560

aattttctta attatacagg aactcctgta aatgaaatgc ctaatgcaag agcttttgta     1620

ggcctaatag atcccaagtt tcctccttcc tatcccaatg ttactaggga acattatact     1680

tcctgtaata ataggaaaag aagaagtgtt gataataact atgctaagtt aaggtctatg     1740

gggtatgcac ttacaggagc agtgcaaacc ttatctcaaa tatcagatat taatgatgaa     1800

aacttacagc aaggaatata tttattaagg gatcatgtaa taaccttaat ggaagctaca     1860

ttgcatgata tatctgttat ggaaggaatg tttgctgtac aacatttgca tacacatttg     1920

aatcatttga agacaatgct tctagaaaga agaatagact ggacctatat gtctagtact     1980

tggctacaac aacaattaca gaaatctgat gatgagatga aagtaataaa gagaattgct     2040

agaagtttgg tatattatgt taaacaaacc catagttctc ccacagctac agcctgggag     2100

attggattat attatgaatt ggttatacct aaacatattt acttgaataa ttggaatgtt     2160

gtcaatatag gtcacttagt taaatcagct ggacaattga ctcatgtaac tatagctcat     2220

ccttatgaaa taatcaataa ggaatgtgta gagactatat atctgcatct tgaggactgc     2280

acaagacaag attatgtcat atgtgatgtg gtaaagatag tgcagccttg tggcaatagc     2340

tcagacacga gtgattgtcc tgtctgggct gaagctgtaa aagaaccatt tgtgcaagtc     2400

aatcctctga aaaacggaag ttatctggtt ttggcaagtt ccacagactg tcagatccca     2460

ccatatgttc ctagcatcgt gactgttaat gaaacaacgt catgctttgg actggacttt     2520

aaaaggccac tggttgcgga agaaagattg agctttgagc cacgactgcc aaatctacaa     2580

ctaagattac cacatttggt tggaattatt gcaaaaatca aagggataaa aatagaagtc     2640

acatcctctg gagaaagtat aaaagagcag attgaaagag caaaagctga gctccttcga     2700

ctggacattc acgagggaga tactcctgcc tggatacaac agctagctgc agcaacaaag     2760

gacgtctggc cagcagcagc ttctgctcta caaggaattg gtaacttttt atctgggact     2820

gcccaaggaa tatttggaac tgcctttagt ctcttgggat acttaaagcc tatcctaata     2880

ggagtagggg tcattctctt ggttattctt atatttaaga ttgtatcatg gattcctacg     2940

aaaaagaaga atcagtag                                                   2958


<210>  458
<211>  985
<212>  PRT
<213>  Spumavirus Human Foamy Virus

<400>  458

Met Thr Leu Gln Gln Trp Ile Ile Trp Lys Lys Met Asn Lys Ala His 
1               5                   10                  15      


Glu Ala Leu Gln Asn Thr Thr Thr Val Thr Glu Gln Gln Lys Glu Gln 
            20                  25                  30          


Ile Ile Leu Asp Ile Gln Asn Glu Glu Val Gln Pro Thr Arg Arg Asp 
        35                  40                  45              


Lys Phe Arg Tyr Leu Leu Tyr Thr Cys Cys Ala Thr Ser Ser Arg Val 
    50                  55                  60                  


Leu Ala Trp Met Phe Leu Val Cys Ile Leu Leu Ile Ile Val Leu Val 
65                  70                  75                  80  


Ser Cys Phe Val Thr Ile Ser Arg Ile Gln Trp Asn Lys Asp Ile Gln 
                85                  90                  95      


Val Leu Gly Pro Val Ile Asp Trp Asn Val Thr Gln Arg Ala Val Tyr 
            100                 105                 110         


Gln Pro Leu Gln Thr Arg Arg Ile Ala Arg Ser Leu Arg Met Gln His 
        115                 120                 125             


Pro Val Pro Lys Tyr Val Glu Val Asn Met Thr Ser Ile Pro Gln Gly 
    130                 135                 140                 


Val Tyr Tyr Glu Pro His Pro Glu Pro Ile Val Val Lys Glu Arg Val 
145                 150                 155                 160 


Leu Gly Leu Ser Gln Ile Leu Met Ile Asn Ser Glu Asn Ile Ala Asn 
                165                 170                 175     


Asn Ala Asn Leu Thr Gln Glu Val Lys Lys Leu Leu Thr Glu Met Val 
            180                 185                 190         


Asn Glu Glu Met Gln Ser Leu Ser Asp Val Met Ile Asp Phe Glu Ile 
        195                 200                 205             


Pro Leu Gly Asp Pro Arg Asp Gln Glu Gln Tyr Ile His Arg Lys Cys 
    210                 215                 220                 


Tyr Gln Glu Phe Ala Asn Cys Tyr Leu Val Lys Tyr Lys Glu Pro Lys 
225                 230                 235                 240 


Pro Trp Pro Lys Glu Gly Leu Ile Ala Asp Gln Cys Pro Leu Pro Gly 
                245                 250                 255     


Tyr His Ala Gly Leu Thr Tyr Asn Arg Gln Ser Ile Trp Asp Tyr Tyr 
            260                 265                 270         


Ile Lys Val Glu Ser Ile Arg Pro Ala Asn Trp Thr Thr Lys Ser Lys 
        275                 280                 285             


Tyr Gly Gln Ala Arg Leu Gly Ser Phe Tyr Ile Pro Ser Ser Leu Arg 
    290                 295                 300                 


Gln Ile Asn Val Ser His Val Leu Phe Cys Ser Asp Gln Leu Tyr Ser 
305                 310                 315                 320 


Lys Trp Tyr Asn Ile Glu Asn Thr Ile Glu Gln Asn Glu Arg Phe Leu 
                325                 330                 335     


Leu Asn Lys Leu Asn Asn Leu Thr Ser Gly Thr Ser Val Leu Lys Lys 
            340                 345                 350         


Arg Ala Leu Pro Lys Asp Trp Ser Ser Gln Gly Lys Asn Ala Leu Phe 
        355                 360                 365             


Arg Glu Ile Asn Val Leu Asp Ile Cys Ser Lys Pro Glu Ser Val Ile 
    370                 375                 380                 


Leu Leu Asn Thr Ser Tyr Tyr Ser Phe Ser Leu Trp Glu Gly Asp Cys 
385                 390                 395                 400 


Asn Phe Thr Lys Asp Met Ile Ser Gln Leu Val Pro Glu Cys Asp Gly 
                405                 410                 415     


Phe Tyr Asn Asn Ser Lys Trp Met His Met His Pro Tyr Ala Cys Arg 
            420                 425                 430         


Phe Trp Arg Ser Lys Lys Asn Glu Lys Glu Glu Thr Lys Cys Arg Asp 
        435                 440                 445             


Gly Glu Thr Lys Arg Cys Leu Tyr Tyr Pro Leu Trp Asp Ser Pro Glu 
    450                 455                 460                 


Ser Thr Tyr Asp Phe Gly Tyr Leu Ala Tyr Gln Lys Asn Phe Pro Ser 
465                 470                 475                 480 


Pro Ile Cys Ile Glu Gln Gln Lys Ile Arg Asp Gln Asp Tyr Glu Val 
                485                 490                 495     


Tyr Ser Leu Tyr Gln Glu Arg Lys Ile Ala Ser Lys Ala Tyr Gly Ile 
            500                 505                 510         


Asp Thr Val Leu Phe Ser Leu Lys Asn Phe Leu Asn Tyr Thr Gly Thr 
        515                 520                 525             


Pro Val Asn Glu Met Pro Asn Ala Arg Ala Phe Val Gly Leu Ile Asp 
    530                 535                 540                 


Pro Lys Phe Pro Pro Ser Tyr Pro Asn Val Thr Arg Glu His Tyr Thr 
545                 550                 555                 560 


Ser Cys Asn Asn Arg Lys Arg Arg Ser Val Asp Asn Asn Tyr Ala Lys 
                565                 570                 575     


Leu Arg Ser Met Gly Tyr Ala Leu Thr Gly Ala Val Gln Thr Leu Ser 
            580                 585                 590         


Gln Ile Ser Asp Ile Asn Asp Glu Asn Leu Gln Gln Gly Ile Tyr Leu 
        595                 600                 605             


Leu Arg Asp His Val Ile Thr Leu Met Glu Ala Thr Leu His Asp Ile 
    610                 615                 620                 


Ser Val Met Glu Gly Met Phe Ala Val Gln His Leu His Thr His Leu 
625                 630                 635                 640 


Asn His Leu Lys Thr Met Leu Leu Glu Arg Arg Ile Asp Trp Thr Tyr 
                645                 650                 655     


Met Ser Ser Thr Trp Leu Gln Gln Gln Leu Gln Lys Ser Asp Asp Glu 
            660                 665                 670         


Met Lys Val Ile Lys Arg Ile Ala Arg Ser Leu Val Tyr Tyr Val Lys 
        675                 680                 685             


Gln Thr His Ser Ser Pro Thr Ala Thr Ala Trp Glu Ile Gly Leu Tyr 
    690                 695                 700                 


Tyr Glu Leu Val Ile Pro Lys His Ile Tyr Leu Asn Asn Trp Asn Val 
705                 710                 715                 720 


Val Asn Ile Gly His Leu Val Lys Ser Ala Gly Gln Leu Thr His Val 
                725                 730                 735     


Thr Ile Ala His Pro Tyr Glu Ile Ile Asn Lys Glu Cys Val Glu Thr 
            740                 745                 750         


Ile Tyr Leu His Leu Glu Asp Cys Thr Arg Gln Asp Tyr Val Ile Cys 
        755                 760                 765             


Asp Val Val Lys Ile Val Gln Pro Cys Gly Asn Ser Ser Asp Thr Ser 
    770                 775                 780                 


Asp Cys Pro Val Trp Ala Glu Ala Val Lys Glu Pro Phe Val Gln Val 
785                 790                 795                 800 


Asn Pro Leu Lys Asn Gly Ser Tyr Leu Val Leu Ala Ser Ser Thr Asp 
                805                 810                 815     


Cys Gln Ile Pro Pro Tyr Val Pro Ser Ile Val Thr Val Asn Glu Thr 
            820                 825                 830         


Thr Ser Cys Phe Gly Leu Asp Phe Lys Arg Pro Leu Val Ala Glu Glu 
        835                 840                 845             


Arg Leu Ser Phe Glu Pro Arg Leu Pro Asn Leu Gln Leu Arg Leu Pro 
    850                 855                 860                 


His Leu Val Gly Ile Ile Ala Lys Ile Lys Gly Ile Lys Ile Glu Val 
865                 870                 875                 880 


Thr Ser Ser Gly Glu Ser Ile Lys Glu Gln Ile Glu Arg Ala Lys Ala 
                885                 890                 895     


Glu Leu Leu Arg Leu Asp Ile His Glu Gly Asp Thr Pro Ala Trp Ile 
            900                 905                 910         


Gln Gln Leu Ala Ala Ala Thr Lys Asp Val Trp Pro Ala Ala Ala Ser 
        915                 920                 925             


Ala Leu Gln Gly Ile Gly Asn Phe Leu Ser Gly Thr Ala Gln Gly Ile 
    930                 935                 940                 


Phe Gly Thr Ala Phe Ser Leu Leu Gly Tyr Leu Lys Pro Ile Leu Ile 
945                 950                 955                 960 


Gly Val Gly Val Ile Leu Leu Val Ile Leu Ile Phe Lys Ile Val Ser 
                965                 970                 975     


Trp Ile Pro Thr Lys Lys Lys Asn Gln 
            980                 985 


<210>  459
<211>  2742
<212>  DNA
<213>  Varicellovirus Pseudorabies virus

<400>  459
atgcctgcag gtggcggatt gtggagagga ccaaggggac atagacctgg acatcatggt       60

ggggcaggtt tgggtaggct ctggccagca cctcatcatg ccgccgccgc tagaggggca      120

gttgcactgg ctcttttgct cctcgcactg gcagcagctc caccatgtgg agccgcagct      180

gttacacgcg ctgctagtgc atctcccacc ccgggcaccg gagcaacgcc aaatgatgtg      240

agcgctgaag ctagtcttga agaaatagaa gcttttagcc ctgggcctag cgaagctcct      300

gatggtgaat atggagatct tgatgcacgt acagcagtcc gagcagcggc cactgaacgc      360

gataggtttt atgtttgtcc cccaccaagc ggaagcactg ttgttagact tgaaccagaa      420

caagcatgtc ctgaatatag ccaaggcagg aattttaccg aaggtatagc agtcctgttt      480

aaagaaaata tcgctcccca taagtttaaa gctcacatat actacaagaa tgtgatagtg      540

acaacagtct ggagtggaag tacctatgca gctattacca atcggtttac ggatcgggta      600

cctgtgcctg tacaagaaat aacagatgta atagataggc gcgggaaatg tgtgagcaaa      660

gcagaatatg taagaaacaa tcataaagtt acagcttttg accgagatga aaatccggta      720

gaagtagatc tccgaccttc ccggctcaat gctctgggta cgcggggatg gcatacaaca      780

aatgatactt atacaaagat aggagcggca ggattttatc ataccgggac aagcgttaat      840

tgtattgtgg aagaagtaga agcacgatct gtctatccat atgattcatt tgcactctct      900

acaggcgata tagtctatat gagccctttc tatgggctcc gtgaaggagc tcatggcgaa      960

catatagggt atgcccctgg caggtttcaa caagtcgaac attattatcc aattgatctt     1020

gattcccggc tgcgggctag tgaatcagtt acaagaaatt tcctgcggac ccctcatttt     1080

accgtagcat gggattgggc acccaaaact cgtagagtct gtagtttggc gaaatggcgt     1140

gaagcggaag aaatgacacg ggatgaaacc cgagatggat catttcgatt tacctcacgt     1200

gctctcggag cttcatttgt atctgatgtt acccaactcg atctccaacg ggtccatctt     1260

ggggattgtg tactgagaga agcgagcgaa gcgattgatg ctatttatcg ccgccgatat     1320

aatagtaccc atgtccttgc gggagatcgt ccggaagttt atctggcgag aggtgggttt     1380

gttgtagcat ttcgacctct cattagcaat gaactcgccc aattgtatgc acgagaactg     1440

gaaagattgg gactggcggg agttgttgga ccagctgctc ctgctgcagc aagacgtgct     1500

agaaggtctc ctggtcctgc cggtaccccg gaaccacccg cagttaatgg gaccggtcat     1560

ttgaggataa caactgggag cgccgagttc gctcggctcc aatttactta tgatcatatt     1620

caagcacatg tcaatgatat gctcggtagg atagcagcgg catggtgtga actccaaaat     1680

aaagatcgaa cactctggtc tgaaatgtca cggctcaatc catccgctgt tgcaacagcg     1740

gcactgggtc aacgagtgtc agcaaggatg ctgggcgatg taatggctat ttctaggtgt     1800

gttgaagtcc ggggtggggt atatgttcaa aattctatgc gtgtcccagg tgaaagaggt     1860

acctgttatt cccgacccct tgtaactttt gaacataatg gaacaggtgt catagaagga     1920

caacttgggg atgataatga actgctgatt tcacgtgatc tgattgaacc ttgtactggt     1980

aatcatcgca ggtatttcaa actgggatct ggatatgtct attatgaaga ttataactat     2040

gtaaggatgg tcgaagttcc ggaaaccatt tccaccaggg tcacactcaa tctcacactc     2100

ctcgaagata gagaatttct tcctcttgaa gtctatacac gggaagaact ggctgatact     2160

gggctgcttg attattccga aattcaacga cgaaatcaac ttcacgccct gaaattttat     2220

gatattgata gggtagttaa agtcgatcac aatgttgtat tgctccgtgg aattgcaaat     2280

ttctttcaag gtcttgggga tgttggagca gctgtgggga aagtcgtgct cggcgctact     2340

ggcgcggtta tttctgcggt gggcgggatg gttagctttc tctctaatcc ttttggagct     2400

ctggcaattg gtcttttggt cttggcgggg cttgttgctg catttcttgc atataggcat     2460

attagcagac ttagaaggaa tccaatgaaa gcactctatc ctgtgactac caaaacactg     2520

aaagaagatg gtgtggatga gggagatgtc gatgaagcaa aacttgatca agctagagat     2580

atgattcgct atatgtctat tgtctcagca cttgaacaac aagaacataa agcaaggaag     2640

aagaatagtg gcccagcact ccttgcgtca agagtgggcg ccatggcaac aaggagacga     2700

cattatcaaa ggctggaaag tgaagatcca gatgcgttgt aa                        2742


<210>  460
<211>  913
<212>  PRT
<213>  Varicellovirus Pseudorabies virus

<400>  460

Met Pro Ala Gly Gly Gly Leu Trp Arg Gly Pro Arg Gly His Arg Pro 
1               5                   10                  15      


Gly His His Gly Gly Ala Gly Leu Gly Arg Leu Trp Pro Ala Pro His 
            20                  25                  30          


His Ala Ala Ala Ala Arg Gly Ala Val Ala Leu Ala Leu Leu Leu Leu 
        35                  40                  45              


Ala Leu Ala Ala Ala Pro Pro Cys Gly Ala Ala Ala Val Thr Arg Ala 
    50                  55                  60                  


Ala Ser Ala Ser Pro Thr Pro Gly Thr Gly Ala Thr Pro Asn Asp Val 
65                  70                  75                  80  


Ser Ala Glu Ala Ser Leu Glu Glu Ile Glu Ala Phe Ser Pro Gly Pro 
                85                  90                  95      


Ser Glu Ala Pro Asp Gly Glu Tyr Gly Asp Leu Asp Ala Arg Thr Ala 
            100                 105                 110         


Val Arg Ala Ala Ala Thr Glu Arg Asp Arg Phe Tyr Val Cys Pro Pro 
        115                 120                 125             


Pro Ser Gly Ser Thr Val Val Arg Leu Glu Pro Glu Gln Ala Cys Pro 
    130                 135                 140                 


Glu Tyr Ser Gln Gly Arg Asn Phe Thr Glu Gly Ile Ala Val Leu Phe 
145                 150                 155                 160 


Lys Glu Asn Ile Ala Pro His Lys Phe Lys Ala His Ile Tyr Tyr Lys 
                165                 170                 175     


Asn Val Ile Val Thr Thr Val Trp Ser Gly Ser Thr Tyr Ala Ala Ile 
            180                 185                 190         


Thr Asn Arg Phe Thr Asp Arg Val Pro Val Pro Val Gln Glu Ile Thr 
        195                 200                 205             


Asp Val Ile Asp Arg Arg Gly Lys Cys Val Ser Lys Ala Glu Tyr Val 
    210                 215                 220                 


Arg Asn Asn His Lys Val Thr Ala Phe Asp Arg Asp Glu Asn Pro Val 
225                 230                 235                 240 


Glu Val Asp Leu Arg Pro Ser Arg Leu Asn Ala Leu Gly Thr Arg Gly 
                245                 250                 255     


Trp His Thr Thr Asn Asp Thr Tyr Thr Lys Ile Gly Ala Ala Gly Phe 
            260                 265                 270         


Tyr His Thr Gly Thr Ser Val Asn Cys Ile Val Glu Glu Val Glu Ala 
        275                 280                 285             


Arg Ser Val Tyr Pro Tyr Asp Ser Phe Ala Leu Ser Thr Gly Asp Ile 
    290                 295                 300                 


Val Tyr Met Ser Pro Phe Tyr Gly Leu Arg Glu Gly Ala His Gly Glu 
305                 310                 315                 320 


His Ile Gly Tyr Ala Pro Gly Arg Phe Gln Gln Val Glu His Tyr Tyr 
                325                 330                 335     


Pro Ile Asp Leu Asp Ser Arg Leu Arg Ala Ser Glu Ser Val Thr Arg 
            340                 345                 350         


Asn Phe Leu Arg Thr Pro His Phe Thr Val Ala Trp Asp Trp Ala Pro 
        355                 360                 365             


Lys Thr Arg Arg Val Cys Ser Leu Ala Lys Trp Arg Glu Ala Glu Glu 
    370                 375                 380                 


Met Thr Arg Asp Glu Thr Arg Asp Gly Ser Phe Arg Phe Thr Ser Arg 
385                 390                 395                 400 


Ala Leu Gly Ala Ser Phe Val Ser Asp Val Thr Gln Leu Asp Leu Gln 
                405                 410                 415     


Arg Val His Leu Gly Asp Cys Val Leu Arg Glu Ala Ser Glu Ala Ile 
            420                 425                 430         


Asp Ala Ile Tyr Arg Arg Arg Tyr Asn Ser Thr His Val Leu Ala Gly 
        435                 440                 445             


Asp Arg Pro Glu Val Tyr Leu Ala Arg Gly Gly Phe Val Val Ala Phe 
    450                 455                 460                 


Arg Pro Leu Ile Ser Asn Glu Leu Ala Gln Leu Tyr Ala Arg Glu Leu 
465                 470                 475                 480 


Glu Arg Leu Gly Leu Ala Gly Val Val Gly Pro Ala Ala Pro Ala Ala 
                485                 490                 495     


Ala Arg Arg Ala Arg Arg Ser Pro Gly Pro Ala Gly Thr Pro Glu Pro 
            500                 505                 510         


Pro Ala Val Asn Gly Thr Gly His Leu Arg Ile Thr Thr Gly Ser Ala 
        515                 520                 525             


Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asp His Ile Gln Ala His Val 
    530                 535                 540                 


Asn Asp Met Leu Gly Arg Ile Ala Ala Ala Trp Cys Glu Leu Gln Asn 
545                 550                 555                 560 


Lys Asp Arg Thr Leu Trp Ser Glu Met Ser Arg Leu Asn Pro Ser Ala 
                565                 570                 575     


Val Ala Thr Ala Ala Leu Gly Gln Arg Val Ser Ala Arg Met Leu Gly 
            580                 585                 590         


Asp Val Met Ala Ile Ser Arg Cys Val Glu Val Arg Gly Gly Val Tyr 
        595                 600                 605             


Val Gln Asn Ser Met Arg Val Pro Gly Glu Arg Gly Thr Cys Tyr Ser 
    610                 615                 620                 


Arg Pro Leu Val Thr Phe Glu His Asn Gly Thr Gly Val Ile Glu Gly 
625                 630                 635                 640 


Gln Leu Gly Asp Asp Asn Glu Leu Leu Ile Ser Arg Asp Leu Ile Glu 
                645                 650                 655     


Pro Cys Thr Gly Asn His Arg Arg Tyr Phe Lys Leu Gly Ser Gly Tyr 
            660                 665                 670         


Val Tyr Tyr Glu Asp Tyr Asn Tyr Val Arg Met Val Glu Val Pro Glu 
        675                 680                 685             


Thr Ile Ser Thr Arg Val Thr Leu Asn Leu Thr Leu Leu Glu Asp Arg 
    690                 695                 700                 


Glu Phe Leu Pro Leu Glu Val Tyr Thr Arg Glu Glu Leu Ala Asp Thr 
705                 710                 715                 720 


Gly Leu Leu Asp Tyr Ser Glu Ile Gln Arg Arg Asn Gln Leu His Ala 
                725                 730                 735     


Leu Lys Phe Tyr Asp Ile Asp Arg Val Val Lys Val Asp His Asn Val 
            740                 745                 750         


Val Leu Leu Arg Gly Ile Ala Asn Phe Phe Gln Gly Leu Gly Asp Val 
        755                 760                 765             


Gly Ala Ala Val Gly Lys Val Val Leu Gly Ala Thr Gly Ala Val Ile 
    770                 775                 780                 


Ser Ala Val Gly Gly Met Val Ser Phe Leu Ser Asn Pro Phe Gly Ala 
785                 790                 795                 800 


Leu Ala Ile Gly Leu Leu Val Leu Ala Gly Leu Val Ala Ala Phe Leu 
                805                 810                 815     


Ala Tyr Arg His Ile Ser Arg Leu Arg Arg Asn Pro Met Lys Ala Leu 
            820                 825                 830         


Tyr Pro Val Thr Thr Lys Thr Leu Lys Glu Asp Gly Val Asp Glu Gly 
        835                 840                 845             


Asp Val Asp Glu Ala Lys Leu Asp Gln Ala Arg Asp Met Ile Arg Tyr 
    850                 855                 860                 


Met Ser Ile Val Ser Ala Leu Glu Gln Gln Glu His Lys Ala Arg Lys 
865                 870                 875                 880 


Lys Asn Ser Gly Pro Ala Leu Leu Ala Ser Arg Val Gly Ala Met Ala 
                885                 890                 895     


Thr Arg Arg Arg His Tyr Gln Arg Leu Glu Ser Glu Asp Pro Asp Ala 
            900                 905                 910         


Leu 
    


<210>  461
<211>  1203
<212>  DNA
<213>  Varicellovirus Pseudorabies virus

<400>  461
atgttgcttg ctgctctcct ggctgctctc gtcgcacgca caacgcttgg ggccgatgta       60

gatgctgttc ctgctcctac atttccaccc ccagcctatc catatacaga atcctggcaa      120

cttacattga ctaccgttcc aagtccgttt gtggggcctg ccgatgtgta tcatacacgg      180

ccattggaag atccatgtgg tgtcgtagcc ttgatttctg atccccaagt cgatcgactt      240

cttaatgaag cagtcgctca tcgtagacct acctatagag ctcatgtcgc ttggtatagg      300

atagcagatg gctgtgccca tctcctctat ttcattgaat atgcagattg tgatccacgg      360

caaatattcg gccggtgtcg caggcggaca acacctatgt ggtggacacc aagtgcagat      420

tatatgtttc ctaccgaaga tgaattgggt ttgctgatgg tagcgcccgg caggtttaat      480

gaagggcaat atcgcagact cgtctcagtg gatggagtaa atattcttac agattttatg      540

gtcgctctgc cagaaggaca ggaatgtcct tttgcgagag tcgatcaaca tcggacatat      600

aaatttggtg cttgttggaa tgatgaatct tttcgcagag gagttgatgt tatgcgtttt      660

ctcactccat tttatcaaca accaccccat cgtgaagtcg taaattattg gtataggaag      720

aatggacgca ccctgccaag ggcgtatgct gcggcaacac cttatgcaat agatccagcc      780

agaccttcag ccggatcacc tcgcccaaga ccaagaccta ggcctcgtcc caaaccggaa      840

ccagcgcccg ttacacctgc tccacctggg aggctccctg aacccgcaac aagagatcat      900

gcagctggcg ggcatccaac acctaggcca ccccgaccag aaacacccca taggccattt      960

gcgccaccag cggtggttcc atctggatgg ccccaacctg ccgaaccttt tcaaccacgc     1020

actccagcag cccccggagt gtctcgtcat cggagcgtca ttgtgggaac tggtactgct     1080

atgggtgccc tgttggtagg agtttgtgtg tatatattct ttcggcttcg aggcgctaaa     1140

ggctacaggc tgttgggtgg cccagctgat acggatgaac tcaaggccca accagggcca     1200

taa                                                                   1203


<210>  462
<211>  400
<212>  PRT
<213>  Varicellovirus Pseudorabies virus

<400>  462

Met Leu Leu Ala Ala Leu Leu Ala Ala Leu Val Ala Arg Thr Thr Leu 
1               5                   10                  15      


Gly Ala Asp Val Asp Ala Val Pro Ala Pro Thr Phe Pro Pro Pro Ala 
            20                  25                  30          


Tyr Pro Tyr Thr Glu Ser Trp Gln Leu Thr Leu Thr Thr Val Pro Ser 
        35                  40                  45              


Pro Phe Val Gly Pro Ala Asp Val Tyr His Thr Arg Pro Leu Glu Asp 
    50                  55                  60                  


Pro Cys Gly Val Val Ala Leu Ile Ser Asp Pro Gln Val Asp Arg Leu 
65                  70                  75                  80  


Leu Asn Glu Ala Val Ala His Arg Arg Pro Thr Tyr Arg Ala His Val 
                85                  90                  95      


Ala Trp Tyr Arg Ile Ala Asp Gly Cys Ala His Leu Leu Tyr Phe Ile 
            100                 105                 110         


Glu Tyr Ala Asp Cys Asp Pro Arg Gln Ile Phe Gly Arg Cys Arg Arg 
        115                 120                 125             


Arg Thr Thr Pro Met Trp Trp Thr Pro Ser Ala Asp Tyr Met Phe Pro 
    130                 135                 140                 


Thr Glu Asp Glu Leu Gly Leu Leu Met Val Ala Pro Gly Arg Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Tyr Arg Arg Leu Val Ser Val Asp Gly Val Asn Ile Leu 
                165                 170                 175     


Thr Asp Phe Met Val Ala Leu Pro Glu Gly Gln Glu Cys Pro Phe Ala 
            180                 185                 190         


Arg Val Asp Gln His Arg Thr Tyr Lys Phe Gly Ala Cys Trp Asn Asp 
        195                 200                 205             


Glu Ser Phe Arg Arg Gly Val Asp Val Met Arg Phe Leu Thr Pro Phe 
    210                 215                 220                 


Tyr Gln Gln Pro Pro His Arg Glu Val Val Asn Tyr Trp Tyr Arg Lys 
225                 230                 235                 240 


Asn Gly Arg Thr Leu Pro Arg Ala Tyr Ala Ala Ala Thr Pro Tyr Ala 
                245                 250                 255     


Ile Asp Pro Ala Arg Pro Ser Ala Gly Ser Pro Arg Pro Arg Pro Arg 
            260                 265                 270         


Pro Arg Pro Arg Pro Lys Pro Glu Pro Ala Pro Val Thr Pro Ala Pro 
        275                 280                 285             


Pro Gly Arg Leu Pro Glu Pro Ala Thr Arg Asp His Ala Ala Gly Gly 
    290                 295                 300                 


His Pro Thr Pro Arg Pro Pro Arg Pro Glu Thr Pro His Arg Pro Phe 
305                 310                 315                 320 


Ala Pro Pro Ala Val Val Pro Ser Gly Trp Pro Gln Pro Ala Glu Pro 
                325                 330                 335     


Phe Gln Pro Arg Thr Pro Ala Ala Pro Gly Val Ser Arg His Arg Ser 
            340                 345                 350         


Val Ile Val Gly Thr Gly Thr Ala Met Gly Ala Leu Leu Val Gly Val 
        355                 360                 365             


Cys Val Tyr Ile Phe Phe Arg Leu Arg Gly Ala Lys Gly Tyr Arg Leu 
    370                 375                 380                 


Leu Gly Gly Pro Ala Asp Thr Asp Glu Leu Lys Ala Gln Pro Gly Pro 
385                 390                 395                 400 


<210>  463
<211>  2061
<212>  DNA
<213>  Varicellovirus Pseudorabies virus

<400>  463
atgcccgcca gttcagtccg gctccctctg cggttgctta ctcttgccgg tcttttggct       60

cttgctggcg cagcagctct ggctcgagga gctccacaag gcggtccacc atcaccccaa      120

ggcgggcctg ctccgacagc tgctccagca agaggaccta cactctttgt gcttgtaggt      180

gatggatcag catggtttgt gtttcaactg ggtggcttgg gagccctgaa tgatacaaga      240

ataaggggac atctcctggg aaggtatctg gtttcatatc aagtagtacc cccacctgtg      300

tcagcttggt atttcgtaca acgtcccaga gaacggccta ggcttagcgg accaccttca      360

ggagctgaac tggtagcttt tgatgcccct ggggtgagaa ggacatatac aaccgctgcc      420

gtttggcctg ccgaagttgc tgttctggca gatgctgaag ccaggtgtcc agctgcagtt      480

ttcaatgtta ccctcgggga agcgtttctg ggtttgaggg tggcattgcg gagcttcttg      540

ccactcgaag tgattattag cgctgaaagg atgcggatga ttgcaccgcc cgcccttggt      600

tccgatctcg aacccccagg gccacctgcc gggcggtttc atgtctatac actgggattt      660

ctgagcgatg gcgctatgca tcaaacaatg agagatgtcg cggcatatgt ccatgaatcc      720

gatgattatc tggctcaact ttcagctgct catgccgcgg ctcttgctgc agtcgtccaa      780

cctggtccat attatttcta tcgggccgcc gtccgactgg gagtagcggc atttgtgttt      840

tcagaagccg ctcgaaggga tagacgggcg agcgcccctg ccctgctccg agtagaatcc      900

gatgctagac tcctttcaag actcctgatg agggccgctg ggtgtcctgc agggtttgca      960

ggtctgtttg atggacgtgc tgaacgagtg cctgtcgctc ctgccgatca actgcgggca     1020

gcatggacat ttggggaaga tcctgcaccg cgtcttgatc tggcaagagc aacggtggca     1080

gaagcctata ggagatctgt tcgaggaaaa ccgtttgatc aacaagccct gttcttcgca     1140

gtggcattgc tcctcagggc aggtgggcct ggggatgcca gagaaactct cctcagaaca     1200

accgcaatgt gtactgctga acgggcagcg gcagcggcgg aactgacaag agcggccctg     1260

agccccaccg cggcctggaa tgaaccattt tccttgttgg atgtgcttag cccatgtgct     1320

gtgtctctca gaagggatct tggcggagat gctacattgg caaatctcgg ggctgcagcc     1380

agattggccc tcgcaccagc gggcgcacct ggggcagctg ccgccactga tgaaggagca     1440

gaagaagaag aagaagatcc ggtggcaaga gcggccccgg aaattccagc tgaagctctc     1500

ttggcgctcc ctctccgagg cggggcatct tttgtcttta caagacgccg acccgattgt     1560

ggacccgcct atacccttgg tggagttgat attgctaatc ctctggtcct tgcaattgtt     1620

tcaaatgatt ccgcagcctg tgattatacc gacagaatgc ctgaaagcca acatcttcct     1680

gccaccgata atcccagcgt ctgtgtttat tgtgattgtg tctttgtcag gtattcaagt     1740

gctgggacca ttctcgaaac tgtgctgata gaaagtaaag atatggaaga acaattgatg     1800

gctggggcta attctactat tccatcattt aatccaacac ttcatggtgg ggatgtgaaa     1860

gctcttatgc tgtttcctaa tggaacagtt gttgatcttt tgagctttac ctctaccaga     1920

ctggcacctg tcagccccgc ttatgttgtt gcatcagttg taggtgccgc tattactgtc     1980

ggcattcttt atgcactttt caaaatgctt tgttcattta gcagtgaagg gtacagcaga     2040

cttattaatg cacgcagcta g                                               2061


<210>  464
<211>  686
<212>  PRT
<213>  Varicellovirus Pseudorabies virus

<400>  464

Met Pro Ala Ser Ser Val Arg Leu Pro Leu Arg Leu Leu Thr Leu Ala 
1               5                   10                  15      


Gly Leu Leu Ala Leu Ala Gly Ala Ala Ala Leu Ala Arg Gly Ala Pro 
            20                  25                  30          


Gln Gly Gly Pro Pro Ser Pro Gln Gly Gly Pro Ala Pro Thr Ala Ala 
        35                  40                  45              


Pro Ala Arg Gly Pro Thr Leu Phe Val Leu Val Gly Asp Gly Ser Ala 
    50                  55                  60                  


Trp Phe Val Phe Gln Leu Gly Gly Leu Gly Ala Leu Asn Asp Thr Arg 
65                  70                  75                  80  


Ile Arg Gly His Leu Leu Gly Arg Tyr Leu Val Ser Tyr Gln Val Val 
                85                  90                  95      


Pro Pro Pro Val Ser Ala Trp Tyr Phe Val Gln Arg Pro Arg Glu Arg 
            100                 105                 110         


Pro Arg Leu Ser Gly Pro Pro Ser Gly Ala Glu Leu Val Ala Phe Asp 
        115                 120                 125             


Ala Pro Gly Val Arg Arg Thr Tyr Thr Thr Ala Ala Val Trp Pro Ala 
    130                 135                 140                 


Glu Val Ala Val Leu Ala Asp Ala Glu Ala Arg Cys Pro Ala Ala Val 
145                 150                 155                 160 


Phe Asn Val Thr Leu Gly Glu Ala Phe Leu Gly Leu Arg Val Ala Leu 
                165                 170                 175     


Arg Ser Phe Leu Pro Leu Glu Val Ile Ile Ser Ala Glu Arg Met Arg 
            180                 185                 190         


Met Ile Ala Pro Pro Ala Leu Gly Ser Asp Leu Glu Pro Pro Gly Pro 
        195                 200                 205             


Pro Ala Gly Arg Phe His Val Tyr Thr Leu Gly Phe Leu Ser Asp Gly 
    210                 215                 220                 


Ala Met His Gln Thr Met Arg Asp Val Ala Ala Tyr Val His Glu Ser 
225                 230                 235                 240 


Asp Asp Tyr Leu Ala Gln Leu Ser Ala Ala His Ala Ala Ala Leu Ala 
                245                 250                 255     


Ala Val Val Gln Pro Gly Pro Tyr Tyr Phe Tyr Arg Ala Ala Val Arg 
            260                 265                 270         


Leu Gly Val Ala Ala Phe Val Phe Ser Glu Ala Ala Arg Arg Asp Arg 
        275                 280                 285             


Arg Ala Ser Ala Pro Ala Leu Leu Arg Val Glu Ser Asp Ala Arg Leu 
    290                 295                 300                 


Leu Ser Arg Leu Leu Met Arg Ala Ala Gly Cys Pro Ala Gly Phe Ala 
305                 310                 315                 320 


Gly Leu Phe Asp Gly Arg Ala Glu Arg Val Pro Val Ala Pro Ala Asp 
                325                 330                 335     


Gln Leu Arg Ala Ala Trp Thr Phe Gly Glu Asp Pro Ala Pro Arg Leu 
            340                 345                 350         


Asp Leu Ala Arg Ala Thr Val Ala Glu Ala Tyr Arg Arg Ser Val Arg 
        355                 360                 365             


Gly Lys Pro Phe Asp Gln Gln Ala Leu Phe Phe Ala Val Ala Leu Leu 
    370                 375                 380                 


Leu Arg Ala Gly Gly Pro Gly Asp Ala Arg Glu Thr Leu Leu Arg Thr 
385                 390                 395                 400 


Thr Ala Met Cys Thr Ala Glu Arg Ala Ala Ala Ala Ala Glu Leu Thr 
                405                 410                 415     


Arg Ala Ala Leu Ser Pro Thr Ala Ala Trp Asn Glu Pro Phe Ser Leu 
            420                 425                 430         


Leu Asp Val Leu Ser Pro Cys Ala Val Ser Leu Arg Arg Asp Leu Gly 
        435                 440                 445             


Gly Asp Ala Thr Leu Ala Asn Leu Gly Ala Ala Ala Arg Leu Ala Leu 
    450                 455                 460                 


Ala Pro Ala Gly Ala Pro Gly Ala Ala Ala Ala Thr Asp Glu Gly Ala 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Asp Pro Val Ala Arg Ala Ala Pro Glu Ile Pro 
                485                 490                 495     


Ala Glu Ala Leu Leu Ala Leu Pro Leu Arg Gly Gly Ala Ser Phe Val 
            500                 505                 510         


Phe Thr Arg Arg Arg Pro Asp Cys Gly Pro Ala Tyr Thr Leu Gly Gly 
        515                 520                 525             


Val Asp Ile Ala Asn Pro Leu Val Leu Ala Ile Val Ser Asn Asp Ser 
    530                 535                 540                 


Ala Ala Cys Asp Tyr Thr Asp Arg Met Pro Glu Ser Gln His Leu Pro 
545                 550                 555                 560 


Ala Thr Asp Asn Pro Ser Val Cys Val Tyr Cys Asp Cys Val Phe Val 
                565                 570                 575     


Arg Tyr Ser Ser Ala Gly Thr Ile Leu Glu Thr Val Leu Ile Glu Ser 
            580                 585                 590         


Lys Asp Met Glu Glu Gln Leu Met Ala Gly Ala Asn Ser Thr Ile Pro 
        595                 600                 605             


Ser Phe Asn Pro Thr Leu His Gly Gly Asp Val Lys Ala Leu Met Leu 
    610                 615                 620                 


Phe Pro Asn Gly Thr Val Val Asp Leu Leu Ser Phe Thr Ser Thr Arg 
625                 630                 635                 640 


Leu Ala Pro Val Ser Pro Ala Tyr Val Val Ala Ser Val Val Gly Ala 
                645                 650                 655     


Ala Ile Thr Val Gly Ile Leu Tyr Ala Leu Phe Lys Met Leu Cys Ser 
            660                 665                 670         


Phe Ser Ser Glu Gly Tyr Ser Arg Leu Ile Asn Ala Arg Ser 
        675                 680                 685     


<210>  465
<211>  471
<212>  DNA
<213>  Varicellovirus Pseudorabies virus

<400>  465
atgagcccac tggtagccgt acttgttttc ttctctgccg ctcttggcat acccggtcct       60

ggagtggccg gtaatccaag gggccttgac gcgatatttg aagctcccgt gactccggcc      120

ccaccaaccc gacacccaag aagagaagaa ctcgaatggg atgacgaaga ccatcccctg      180

cttgatctgg aacccccagt cggttctaga tgtcaccctt atattgccta tagtttgccc      240

ccagatatga atgcggtgac ctctgtcgtg gtcaaaccgt attgtagccc acccgaagtg      300

atattgtggg cctcaggaac tgcatatctc gttaatccgt tcgttgcgat tcaagctttg      360

gctgtgggag aaccactgaa cgaagctgcg ttgaaagaac ttggcgaagt cgcagtccat      420

aaagattcat tgccaccctt gcgttacaac ggtggaccac cggctgaatg a               471


<210>  466
<211>  156
<212>  PRT
<213>  Varicellovirus Pseudorabies virus

<400>  466

Met Ser Pro Leu Val Ala Val Leu Val Phe Phe Ser Ala Ala Leu Gly 
1               5                   10                  15      


Ile Pro Gly Pro Gly Val Ala Gly Asn Pro Arg Gly Leu Asp Ala Ile 
            20                  25                  30          


Phe Glu Ala Pro Val Thr Pro Ala Pro Pro Thr Arg His Pro Arg Arg 
        35                  40                  45              


Glu Glu Leu Glu Trp Asp Asp Glu Asp His Pro Leu Leu Asp Leu Glu 
    50                  55                  60                  


Pro Pro Val Gly Ser Arg Cys His Pro Tyr Ile Ala Tyr Ser Leu Pro 
65                  70                  75                  80  


Pro Asp Met Asn Ala Val Thr Ser Val Val Val Lys Pro Tyr Cys Ser 
                85                  90                  95      


Pro Pro Glu Val Ile Leu Trp Ala Ser Gly Thr Ala Tyr Leu Val Asn 
            100                 105                 110         


Pro Phe Val Ala Ile Gln Ala Leu Ala Val Gly Glu Pro Leu Asn Glu 
        115                 120                 125             


Ala Ala Leu Lys Glu Leu Gly Glu Val Ala Val His Lys Asp Ser Leu 
    130                 135                 140                 


Pro Pro Leu Arg Tyr Asn Gly Gly Pro Pro Ala Glu 
145                 150                 155     


<210>  467
<211>  2715
<212>  DNA
<213>  Simplexvirus Herpes simplex virus 1

<400>  467
atgaggcaag gtgcacctgc caggggtcgg agatggtttg ttgtatgggc tctgctggga       60

ctgactttgg gcgtgctcgt tgcttccgca gcaccctctt ctccaggaac acctggcgtg      120

gctgcagcca cgcaagctgc taatggcggg ccagctaccc cagccccacc ggcaccagga      180

gctccaccta ctggcgatcc caagccaaag aagaataaga agccaaagcc acctaaaccc      240

cctcgaccag ctggtgataa tgctacagtg gctgcaggtc atgctacact cagagaacat      300

cttagagata taaaagctga aaatacagac gctaatttct atgtctgtcc cccacctaca      360

ggtgcaaccg ttgtccaatt tgaacaaccc aggagatgtc ctacacgtcc agaagggcag      420

aattataccg aaggtatagc cgttgtgttt aaagaaaata ttgcaccata taaatttaaa      480

gcgacgatgt attataagga tgtgacagtc agccaagtat ggtttgggca tcgatatagc      540

caattcatgg gcattttcga agatagagca cctgtaccgt ttgaagaagt tatagataaa      600

ataaatgcaa aaggcgtgtg ccgtagcaca gcgaaatatg ttcggaataa tttggaaaca      660

acggcattcc atcgcgatga tcatgaaaca gatatggaac ttaagcccgc aaatgctgcc      720

acacgtacct ctcgtgggtg gcatactaca gatctgaaat ataatccatc acgagtcgaa      780

gcatttcatc gatatggaac aaccgtgaat tgtattgtgg aagaagttga tgccagaagt      840

gtttatcctt atgatgaatt cgtcctcgca acaggagatt tcgtttatat gtcaccattc      900

tatggatatc gtgaaggtag tcatacagag catacttctt atgcagcaga taggtttaaa      960

caagtggatg gtttctatgc tcgggatttg actacaaaag caagagctac agcccccaca     1020

actcgaaatc ttctgaccac tcctaaattt actgtagcgt gggattgggt acccaaacga     1080

ccatccgtat gtactatgac aaaatggcaa gaagtagatg aaatgcttcg gtctgaatat     1140

ggtggaagct ttagattttc aagtgatgca atctctacta catttacaac taatctcaca     1200

gaatatcccc tttcacgagt cgatttggga gattgtattg gtaaagatgc gcgggatgca     1260

atggatcgga tatttgctcg tagatataat gccacacata taaaagttgg acaaccacaa     1320

tattatctcg caaacggcgg gttcctcatt gcctatcaac cgctcctttc taatactctt     1380

gccgaactct atgtccgaga gcatctgagg gaacaatcac gtaaaccgcc gaatccaaca     1440

cctcctccgc ctggagcatc cgcgaatgcc tctgtcgaac gtataaagac aacgtcttca     1500

attgaatttg ctagacttca attcacctat aatcatatcc aaaggcacgt taatgacatg     1560

ctgggtagag tcgcaattgc ttggtgtgaa ttgcaaaacc atgaacttac gttgtggaat     1620

gaagcacgta aattgaatcc aaatgcaatt gctagcgcga cggttggacg cagagtttcc     1680

gcccgaatgc tgggagatgt tatggcagtt tctacatgtg tccccgtggc tgccgataat     1740

gtcatagtgc agaattcaat gagaatatct agccgacctg gtgcatgtta ttctagacca     1800

ctcgtgagtt tccgctatga ggatcaaggg cccctggttg aaggccaact cggagaaaat     1860

aatgaattgc gcttgacaag ggacgcaatt gaaccatgta cagttggcca tcgccggtat     1920

tttacatttg gcggcgggta tgtctacttt gaggaatatg cctatagtca tcaactttct     1980

cgtgctgata ttacaactgt gtcaacattt attgatctga atattacgat gcttgaagac     2040

cacgaattcg taccgttgga agtctataca cgccatgaga taaaagattc cgggcttttg     2100

gattataccg aagtgcaacg acggaatcaa ctccatgatc tccgattcgc ggatattgat     2160

accgtaattc atgctgatgc aaatgctgct atgtttgctg gacttggggc attctttgaa     2220

ggaatgggcg atctcggaag agcagttggg aaagtcgtta tgggaatagt tggtggtgtc     2280

gttagtgcgg tttcaggtgt cagcagcttt atgagcaatc cattcggcgc cctcgcagtt     2340

gggctcctgg tgcttgctgg gcttgctgct gctttctttg ctttccggta tgtgatgagg     2400

cttcaatcca atccaatgaa agcactttat cccttgacta ctaaagaact gaagaatccg     2460

actaatcctg atgcttcagg agaaggggaa gaaggcgggg atttcgatga agctaaactg     2520

gcggaagcac gtgaaatgat ccgttatatg gcattggtca gcgctatgga aagaaccgag     2580

cataaagcta agaagaaagg aacttctgcc cttctctctg ctaaagttac tgatatggtg     2640

atgagaaaac ggcgtaatac aaattatact caggtaccga ataaggatgg cgatgcagat     2700

gaagatgatt tgtaa                                                      2715


<210>  468
<211>  904
<212>  PRT
<213>  Simplexvirus Herpes simplex virus 1

<400>  468

Met Arg Gln Gly Ala Pro Ala Arg Gly Arg Arg Trp Phe Val Val Trp 
1               5                   10                  15      


Ala Leu Leu Gly Leu Thr Leu Gly Val Leu Val Ala Ser Ala Ala Pro 
            20                  25                  30          


Ser Ser Pro Gly Thr Pro Gly Val Ala Ala Ala Thr Gln Ala Ala Asn 
        35                  40                  45              


Gly Gly Pro Ala Thr Pro Ala Pro Pro Ala Pro Gly Ala Pro Pro Thr 
    50                  55                  60                  


Gly Asp Pro Lys Pro Lys Lys Asn Lys Lys Pro Lys Pro Pro Lys Pro 
65                  70                  75                  80  


Pro Arg Pro Ala Gly Asp Asn Ala Thr Val Ala Ala Gly His Ala Thr 
                85                  90                  95      


Leu Arg Glu His Leu Arg Asp Ile Lys Ala Glu Asn Thr Asp Ala Asn 
            100                 105                 110         


Phe Tyr Val Cys Pro Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu 
        115                 120                 125             


Gln Pro Arg Arg Cys Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu 
    130                 135                 140                 


Gly Ile Ala Val Val Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Ala Thr Met Tyr Tyr Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly 
                165                 170                 175     


His Arg Tyr Ser Gln Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val 
            180                 185                 190         


Pro Phe Glu Glu Val Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg 
        195                 200                 205             


Ser Thr Ala Lys Tyr Val Arg Asn Asn Leu Glu Thr Thr Ala Phe His 
    210                 215                 220                 


Arg Asp Asp His Glu Thr Asp Met Glu Leu Lys Pro Ala Asn Ala Ala 
225                 230                 235                 240 


Thr Arg Thr Ser Arg Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro 
                245                 250                 255     


Ser Arg Val Glu Ala Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile 
            260                 265                 270         


Val Glu Glu Val Asp Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val 
        275                 280                 285             


Leu Ala Thr Gly Asp Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg 
    290                 295                 300                 


Glu Gly Ser His Thr Glu His Thr Ser Tyr Ala Ala Asp Arg Phe Lys 
305                 310                 315                 320 


Gln Val Asp Gly Phe Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala 
                325                 330                 335     


Thr Ala Pro Thr Thr Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val 
            340                 345                 350         


Ala Trp Asp Trp Val Pro Lys Arg Pro Ser Val Cys Thr Met Thr Lys 
        355                 360                 365             


Trp Gln Glu Val Asp Glu Met Leu Arg Ser Glu Tyr Gly Gly Ser Phe 
    370                 375                 380                 


Arg Phe Ser Ser Asp Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr 
385                 390                 395                 400 


Glu Tyr Pro Leu Ser Arg Val Asp Leu Gly Asp Cys Ile Gly Lys Asp 
                405                 410                 415     


Ala Arg Asp Ala Met Asp Arg Ile Phe Ala Arg Arg Tyr Asn Ala Thr 
            420                 425                 430         


His Ile Lys Val Gly Gln Pro Gln Tyr Tyr Leu Ala Asn Gly Gly Phe 
        435                 440                 445             


Leu Ile Ala Tyr Gln Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr 
    450                 455                 460                 


Val Arg Glu His Leu Arg Glu Gln Ser Arg Lys Pro Pro Asn Pro Thr 
465                 470                 475                 480 


Pro Pro Pro Pro Gly Ala Ser Ala Asn Ala Ser Val Glu Arg Ile Lys 
                485                 490                 495     


Thr Thr Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His 
            500                 505                 510         


Ile Gln Arg His Val Asn Asp Met Leu Gly Arg Val Ala Ile Ala Trp 
        515                 520                 525             


Cys Glu Leu Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys 
    530                 535                 540                 


Leu Asn Pro Asn Ala Ile Ala Ser Ala Thr Val Gly Arg Arg Val Ser 
545                 550                 555                 560 


Ala Arg Met Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val 
                565                 570                 575     


Ala Ala Asp Asn Val Ile Val Gln Asn Ser Met Arg Ile Ser Ser Arg 
            580                 585                 590         


Pro Gly Ala Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp 
        595                 600                 605             


Gln Gly Pro Leu Val Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg 
    610                 615                 620                 


Leu Thr Arg Asp Ala Ile Glu Pro Cys Thr Val Gly His Arg Arg Tyr 
625                 630                 635                 640 


Phe Thr Phe Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser 
                645                 650                 655     


His Gln Leu Ser Arg Ala Asp Ile Thr Thr Val Ser Thr Phe Ile Asp 
            660                 665                 670         


Leu Asn Ile Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val 
        675                 680                 685             


Tyr Thr Arg His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu 
    690                 695                 700                 


Val Gln Arg Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp 
705                 710                 715                 720 


Thr Val Ile His Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Gly 
                725                 730                 735     


Ala Phe Phe Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val 
            740                 745                 750         


Val Met Gly Ile Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser 
        755                 760                 765             


Ser Phe Met Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val 
    770                 775                 780                 


Leu Ala Gly Leu Ala Ala Ala Phe Phe Ala Phe Arg Tyr Val Met Arg 
785                 790                 795                 800 


Leu Gln Ser Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu 
                805                 810                 815     


Leu Lys Asn Pro Thr Asn Pro Asp Ala Ser Gly Glu Gly Glu Glu Gly 
            820                 825                 830         


Gly Asp Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 
        835                 840                 845             


Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Lys 
    850                 855                 860                 


Lys Lys Gly Thr Ser Ala Leu Leu Ser Ala Lys Val Thr Asp Met Val 
865                 870                 875                 880 


Met Arg Lys Arg Arg Asn Thr Asn Tyr Thr Gln Val Pro Asn Lys Asp 
                885                 890                 895     


Gly Asp Ala Asp Glu Asp Asp Leu 
            900                 


<210>  469
<211>  1185
<212>  DNA
<213>  Simplexvirus Herpes simplex virus 1

<400>  469
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtgggcctc       60

catggggtcc gcagcaaata tgccttggtg gatgcctctc tcaagatggc cgaccccaat      120

cgctttcgcg gcaaagacct tccggtcctg gaccagctga ccgaccctcc gggggtccgg      180

cgcgtgtacc acatccaggc gggcctaccg gacccgttcc agccccccag cctcccgatc      240

acggtttact acgccgtgtt ggagcgcgcc tgccgcagcg tgctcctaaa cgcaccgtcg      300

gaggcccccc agattgtccg cggggcctcc gaagacgtcc ggaaacaacc ctacaacctg      360

accatcgctt ggtttcggat gggaggcaac tgtgctatcc ccatcacggt catggagtac      420

accgaatgct cctacaacaa gtctctgggg gcctgtccca tccgaacgca gccccgctgg      480

aactactatg acagcttcag cgccgtcagc gaggataacc tggggttcct gatgcacgcc      540

cccgcgtttg agaccgccgg cacgtacctg cggctcgtga agataaacga ctggacggag      600

attacacagt ttatcctgga gcaccgagcc aagggctcct gtaagtacgc cctcccgctg      660

cgcatccccc cgtcagcctg cctctccccc caggcctacc agcagggggt gacggtggac      720

agcatcggga tgctgccccg cttcatcccc gagaaccagc gcaccgtcgc cgtatacagc      780

ttgaagatcg ccgggtggca cgggcccaag gccccataca cgagcaccct gctgcccccg      840

gagctgtccg agacccccaa cgccacgcag ccagaactcg ccccggaaga ccccgaggat      900

tcggccctct tggaggaccc cgtggggacg gtggcgccgc aaatcccacc aaactggcac      960

ataccgtcga tccaggacgc cgcgacgcct taccatcccc cggccacccc gaacaacatg     1020

ggcctgatcg ccggcgcggt gggcggcagt ctcctggcag ccctggtcat ttgcggaatt     1080

gtgtactgga tgcgccgcca cactcaaaaa gccccaaagc gcatacgcct cccccacatc     1140

cgggaagacg accagccgtc ctcgcaccag cccttgtttt actag                     1185


<210>  470
<211>  394
<212>  PRT
<213>  Simplexvirus Herpes simplex virus 1

<400>  470

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Ser Lys Tyr Ala Leu Val Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


Asn Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp 
            100                 105                 110         


Val Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly 
        115                 120                 125             


Gly Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Asn Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ser Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr 
                325                 330                 335     


Pro Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu 
            340                 345                 350         


Ala Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg His Thr 
        355                 360                 365             


Gln Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp 
    370                 375                 380                 


Gln Pro Ser Ser His Gln Pro Leu Phe Tyr 
385                 390                 


<210>  471
<211>  2517
<212>  DNA
<213>  Simplexvirus Herpes simplex virus 1

<400>  471
atgggaaacg gcttgtggtt tgttggtgtg ataatcctgg gagtagcctg gggccaagta       60

catgattgga cagaacaaac cgatccttgg ttcctggacg gacttgggat ggatcggatg      120

tattggcgag atacaaatac tggaagactc tggcttccta atacaccaga tcctcagaag      180

ccacccaggg gcttccttgc tccaccagat gagctcaatc ttacaacagc tagtctcccg      240

ctgctgagat ggtatgaaga acggttctgc ttcgtgctgg taacaaccgc tgaattccct      300

cgcgatccag gacaattgtt gtatattccc aaaacatatc ttctgggtcg accacccaat      360

gcctctctcc cagcacctac tacagtggaa ccaacagctc aacccccgcc gtccgtggct      420

cctctgaaag ggcttctgca taaccccgta gcatcagtct tgctccgcag tcgtgcgtgg      480

gtcacattca gcgctgtgcc cgatcctgaa gcactcactt ttcccagggg cgataatgtc      540

gccacagcat ctcatccttc tggaccacgc gacactccac cccctcgccc acctgtcggc      600

gctcgcaggc atcccacaac agaacttgat attactcatc ttcataatgc ctcaactaca      660

tggctggcta caagagggct tctgcggagc cccgggagat atgtctactt ttctccctct      720

gcttctacat ggccagttgg aatatggaca actggtgaac ttgtccttgg ttgtgacgca      780

gcacttgtca gggcccggta tggtcgcgag tttatgggac tggtcatctc aatgcatgat      840

tcaccgccag tcgaggtcat ggttgtgccg gccggtcaaa cactggaccg agtgggagat      900

cctgcagatg aaaatccacc tggcgccctg ccaggcccac ccggtggacc aaggtaccgc      960

gtgttcgtgc tcggttcact cacccgtgca gataatggta gcgccttgga tgcactgaga     1020

cgtgtcggtg ggtatcctga agaagggacc aattatgcac aatttctcag tagggcgtat     1080

gctgaattct ttagcggaga tgctggagct gaacaagggc cacggccacc cttgttttgg     1140

cggctcactg gactcctggc cacctctgga ttcgcatttg tcaatgctgc tcatgccaat     1200

ggggctgtat gtctgtctga tctcttgggg ttccttgctc atagtcgagc cctcgcaggc     1260

ctggctgctc ggggagctgc cggttgcgca gccgacagtg tcttcttcaa cgtttccgtg     1320

cttgacccga ctgcaagact tcaactggaa gcaagattgc aacatctcgt tgcagaaatc     1380

ttggaaaggg agcaatccct ggctctgcat gcactcggat accaactcgc atttgtactt     1440

gactcccctt ccgcctatga tgccgttgca ccttctgccg ctcacctgat tgatgcattg     1500

tacgcagaat tcctcggcgg aagggttctt actactccag tggtgcatag ggccttgttc     1560

tatgcttctg cggtattgag acaaccattt ctggccggag tgcctagcgc cgtccaaagg     1620

gagcgagcta ggagatcact cctgattgcc tctgcactct gcacatctga tgtagcagcc     1680

gccacaaatg ctgatctgag gactgccctc gctagagctg atcatcaaaa gacgcttttc     1740

tggctccccg atcatttcag tccttgtgca gcgtcactta gattcgacct tgatgaatca     1800

gtcttcatat tggatgcact cgcccaggca actagatctg aaacacctgt tgaggtgctc     1860

gctcaacaaa cacatggttt ggcttctaca ctcacaaggt gggcccatta taatgcattg     1920

attcgggctt ttgtgcccga agcgtcccac cgatgtggcg gacaatcagc aaatgtggaa     1980

cccaggatat tggtgcctat tacgcataat gcttcttatg tggttacgca tagcccattg     2040

ccacgcggca ttgggtataa actgacgggt gtggatgttc gcagacctct gtttctgact     2100

tatctgacag caacctgtga gggttctact cgcgacattg aaagcaaacg tctcgtaagg     2160

acgcagaatc aaagagattt gggtctggtt ggcgctgttt tcatgaggta tactcccgca     2220

ggcgaagtta tgagcgtcct gctcgtcgac accgataata cccaacaaca gattgcagcg     2280

ggccccacag aaggggctcc atcagtcttc tccagcgatg ttccttcaac cgcgctgctc     2340

ctgttcccga atggcacggt tatccacctg ttggcgttcg atacacaacc tgtcgcagcc     2400

atcgcaccgg gattcttggc tgcatccgcc ctcggggttg tgatgataac agcagctctc     2460

gcggggatac tgaaagtgct gcgcaccagc gtgcccttct tctggcgacg agagtga        2517


<210>  472
<211>  838
<212>  PRT
<213>  Simplexvirus Herpes simplex virus 1

<400>  472

Met Gly Asn Gly Leu Trp Phe Val Gly Val Ile Ile Leu Gly Val Ala 
1               5                   10                  15      


Trp Gly Gln Val His Asp Trp Thr Glu Gln Thr Asp Pro Trp Phe Leu 
            20                  25                  30          


Asp Gly Leu Gly Met Asp Arg Met Tyr Trp Arg Asp Thr Asn Thr Gly 
        35                  40                  45              


Arg Leu Trp Leu Pro Asn Thr Pro Asp Pro Gln Lys Pro Pro Arg Gly 
    50                  55                  60                  


Phe Leu Ala Pro Pro Asp Glu Leu Asn Leu Thr Thr Ala Ser Leu Pro 
65                  70                  75                  80  


Leu Leu Arg Trp Tyr Glu Glu Arg Phe Cys Phe Val Leu Val Thr Thr 
                85                  90                  95      


Ala Glu Phe Pro Arg Asp Pro Gly Gln Leu Leu Tyr Ile Pro Lys Thr 
            100                 105                 110         


Tyr Leu Leu Gly Arg Pro Pro Asn Ala Ser Leu Pro Ala Pro Thr Thr 
        115                 120                 125             


Val Glu Pro Thr Ala Gln Pro Pro Pro Ser Val Ala Pro Leu Lys Gly 
    130                 135                 140                 


Leu Leu His Asn Pro Val Ala Ser Val Leu Leu Arg Ser Arg Ala Trp 
145                 150                 155                 160 


Val Thr Phe Ser Ala Val Pro Asp Pro Glu Ala Leu Thr Phe Pro Arg 
                165                 170                 175     


Gly Asp Asn Val Ala Thr Ala Ser His Pro Ser Gly Pro Arg Asp Thr 
            180                 185                 190         


Pro Pro Pro Arg Pro Pro Val Gly Ala Arg Arg His Pro Thr Thr Glu 
        195                 200                 205             


Leu Asp Ile Thr His Leu His Asn Ala Ser Thr Thr Trp Leu Ala Thr 
    210                 215                 220                 


Arg Gly Leu Leu Arg Ser Pro Gly Arg Tyr Val Tyr Phe Ser Pro Ser 
225                 230                 235                 240 


Ala Ser Thr Trp Pro Val Gly Ile Trp Thr Thr Gly Glu Leu Val Leu 
                245                 250                 255     


Gly Cys Asp Ala Ala Leu Val Arg Ala Arg Tyr Gly Arg Glu Phe Met 
            260                 265                 270         


Gly Leu Val Ile Ser Met His Asp Ser Pro Pro Val Glu Val Met Val 
        275                 280                 285             


Val Pro Ala Gly Gln Thr Leu Asp Arg Val Gly Asp Pro Ala Asp Glu 
    290                 295                 300                 


Asn Pro Pro Gly Ala Leu Pro Gly Pro Pro Gly Gly Pro Arg Tyr Arg 
305                 310                 315                 320 


Val Phe Val Leu Gly Ser Leu Thr Arg Ala Asp Asn Gly Ser Ala Leu 
                325                 330                 335     


Asp Ala Leu Arg Arg Val Gly Gly Tyr Pro Glu Glu Gly Thr Asn Tyr 
            340                 345                 350         


Ala Gln Phe Leu Ser Arg Ala Tyr Ala Glu Phe Phe Ser Gly Asp Ala 
        355                 360                 365             


Gly Ala Glu Gln Gly Pro Arg Pro Pro Leu Phe Trp Arg Leu Thr Gly 
    370                 375                 380                 


Leu Leu Ala Thr Ser Gly Phe Ala Phe Val Asn Ala Ala His Ala Asn 
385                 390                 395                 400 


Gly Ala Val Cys Leu Ser Asp Leu Leu Gly Phe Leu Ala His Ser Arg 
                405                 410                 415     


Ala Leu Ala Gly Leu Ala Ala Arg Gly Ala Ala Gly Cys Ala Ala Asp 
            420                 425                 430         


Ser Val Phe Phe Asn Val Ser Val Leu Asp Pro Thr Ala Arg Leu Gln 
        435                 440                 445             


Leu Glu Ala Arg Leu Gln His Leu Val Ala Glu Ile Leu Glu Arg Glu 
    450                 455                 460                 


Gln Ser Leu Ala Leu His Ala Leu Gly Tyr Gln Leu Ala Phe Val Leu 
465                 470                 475                 480 


Asp Ser Pro Ser Ala Tyr Asp Ala Val Ala Pro Ser Ala Ala His Leu 
                485                 490                 495     


Ile Asp Ala Leu Tyr Ala Glu Phe Leu Gly Gly Arg Val Leu Thr Thr 
            500                 505                 510         


Pro Val Val His Arg Ala Leu Phe Tyr Ala Ser Ala Val Leu Arg Gln 
        515                 520                 525             


Pro Phe Leu Ala Gly Val Pro Ser Ala Val Gln Arg Glu Arg Ala Arg 
    530                 535                 540                 


Arg Ser Leu Leu Ile Ala Ser Ala Leu Cys Thr Ser Asp Val Ala Ala 
545                 550                 555                 560 


Ala Thr Asn Ala Asp Leu Arg Thr Ala Leu Ala Arg Ala Asp His Gln 
                565                 570                 575     


Lys Thr Leu Phe Trp Leu Pro Asp His Phe Ser Pro Cys Ala Ala Ser 
            580                 585                 590         


Leu Arg Phe Asp Leu Asp Glu Ser Val Phe Ile Leu Asp Ala Leu Ala 
        595                 600                 605             


Gln Ala Thr Arg Ser Glu Thr Pro Val Glu Val Leu Ala Gln Gln Thr 
    610                 615                 620                 


His Gly Leu Ala Ser Thr Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
625                 630                 635                 640 


Ile Arg Ala Phe Val Pro Glu Ala Ser His Arg Cys Gly Gly Gln Ser 
                645                 650                 655     


Ala Asn Val Glu Pro Arg Ile Leu Val Pro Ile Thr His Asn Ala Ser 
            660                 665                 670         


Tyr Val Val Thr His Ser Pro Leu Pro Arg Gly Ile Gly Tyr Lys Leu 
        675                 680                 685             


Thr Gly Val Asp Val Arg Arg Pro Leu Phe Leu Thr Tyr Leu Thr Ala 
    690                 695                 700                 


Thr Cys Glu Gly Ser Thr Arg Asp Ile Glu Ser Lys Arg Leu Val Arg 
705                 710                 715                 720 


Thr Gln Asn Gln Arg Asp Leu Gly Leu Val Gly Ala Val Phe Met Arg 
                725                 730                 735     


Tyr Thr Pro Ala Gly Glu Val Met Ser Val Leu Leu Val Asp Thr Asp 
            740                 745                 750         


Asn Thr Gln Gln Gln Ile Ala Ala Gly Pro Thr Glu Gly Ala Pro Ser 
        755                 760                 765             


Val Phe Ser Ser Asp Val Pro Ser Thr Ala Leu Leu Leu Phe Pro Asn 
    770                 775                 780                 


Gly Thr Val Ile His Leu Leu Ala Phe Asp Thr Gln Pro Val Ala Ala 
785                 790                 795                 800 


Ile Ala Pro Gly Phe Leu Ala Ala Ser Ala Leu Gly Val Val Met Ile 
                805                 810                 815     


Thr Ala Ala Leu Ala Gly Ile Leu Lys Val Leu Arg Thr Ser Val Pro 
            820                 825                 830         


Phe Phe Trp Arg Arg Glu 
        835             


<210>  473
<211>  675
<212>  DNA
<213>  Simplexvirus Herpes simplex virus 1

<400>  473
atggggattt tgggttgggt cgggcttatt gccgttgggg ttttgtgtgt gcgggggggc       60

ttgccttcaa ccgaatatgt tattcggagt cgggtggctc gagaggtggg ggatatatta      120

aaggtgcctt gtgtgccgct cccgtctgac gatcttgatt ggcgttacga gaccccctcg      180

gctataaact atgctttgat agacggtata tttttgcgtt atcactgtcc cggattggac      240

acggtcttgt gggataggca tgcccagaag gcatattggg ttaacccctt tttatttgtg      300

gcgggttttt tggaggactt gagttacccc gcgtttcctg ccaacaccca ggaaacagaa      360

acgcgcttgg ccctttataa agagatacgc caggcgctgg acagtcgcaa gcaggccgcc      420

agccacacac ctgtgaaggc tgggtgtgtg aactttgact attcgcgcac ccgccgctgt      480

gtagggcgac aggatttggg acctaccaac ggaacgtctg gacggacccc ggttctgccg      540

ccggacgatg aagcgggcct gcagccgaag cccctcacca cgccgccgcc catcatcgcc      600

acgtcggacc ccaccccgcg acgggacgcc gccacaaaaa gcagacgccg acgaccccac      660

tcccggcgcc tctaa                                                       675


<210>  474
<211>  224
<212>  PRT
<213>  Simplexvirus Herpes simplex virus 1

<400>  474

Met Gly Ile Leu Gly Trp Val Gly Leu Ile Ala Val Gly Val Leu Cys 
1               5                   10                  15      


Val Arg Gly Gly Leu Pro Ser Thr Glu Tyr Val Ile Arg Ser Arg Val 
            20                  25                  30          


Ala Arg Glu Val Gly Asp Ile Leu Lys Val Pro Cys Val Pro Leu Pro 
        35                  40                  45              


Ser Asp Asp Leu Asp Trp Arg Tyr Glu Thr Pro Ser Ala Ile Asn Tyr 
    50                  55                  60                  


Ala Leu Ile Asp Gly Ile Phe Leu Arg Tyr His Cys Pro Gly Leu Asp 
65                  70                  75                  80  


Thr Val Leu Trp Asp Arg His Ala Gln Lys Ala Tyr Trp Val Asn Pro 
                85                  90                  95      


Phe Leu Phe Val Ala Gly Phe Leu Glu Asp Leu Ser Tyr Pro Ala Phe 
            100                 105                 110         


Pro Ala Asn Thr Gln Glu Thr Glu Thr Arg Leu Ala Leu Tyr Lys Glu 
        115                 120                 125             


Ile Arg Gln Ala Leu Asp Ser Arg Lys Gln Ala Ala Ser His Thr Pro 
    130                 135                 140                 


Val Lys Ala Gly Cys Val Asn Phe Asp Tyr Ser Arg Thr Arg Arg Cys 
145                 150                 155                 160 


Val Gly Arg Gln Asp Leu Gly Pro Thr Asn Gly Thr Ser Gly Arg Thr 
                165                 170                 175     


Pro Val Leu Pro Pro Asp Asp Glu Ala Gly Leu Gln Pro Lys Pro Leu 
            180                 185                 190         


Thr Thr Pro Pro Pro Ile Ile Ala Thr Ser Asp Pro Thr Pro Arg Arg 
        195                 200                 205             


Asp Ala Ala Thr Lys Ser Arg Arg Arg Arg Pro His Ser Arg Arg Leu 
    210                 215                 220                 


<210>  475
<211>  1746
<212>  DNA
<213>  Hepacivirus Hepatitis C Virus

<400>  475
atgggttgct ctttttctat cttcttactt gcccttctgt cgtgccttac agtgccagcg       60

tctgcggtgg aagttaggaa cgtcagttct agctactatg ccaccaatga ttgctcgaac      120

agcagcatca cctggcaact caacaacgca gttctccacc ttcctggatg cgtcccatgt      180

gagaatgata acggcacctt gcactgctgg atacaagtaa caccaaatgt ggctgtgaaa      240

caccgcggcg cgctcactca taacctgcgg acgcacgtcg atatgatcgt aatggcagct      300

acggtctgtt cggccctgta tgtgggagac atgtgcgggg ccgtgatgat tgtgtcgcag      360

gctctcataa tatcgccaga acgccacaac ttcacccaag agtgcaactg ttccatctac      420

caaggtcata tcactggcca tcgcatggca tgggacatga tgctaaactg gtcaccaact      480

cttaccatga tccttgctta tgccgctcgt gttcccgagc tagtccttga agttgtcttt      540

ggtggtcatt ggggtgtggt atttggcttg gcctatttct ccatgcaggg agcgtgggcc      600

aaggtcattg ccatcctcct tcttgttgcg ggagtggacg cagagactca taccaccggc      660

tcagctgcgg gtcatgccgc aagggggttt gccaacctcc ttagtcctgg ttccaagcaa      720

aaaataagtt tgatcaatac caatggcagc tggcacataa accggaccgc ccttaattgt      780

aatgacagct tgcagacggg tttcctcgct tctttgtttt acgtcaacaa cttcaacagc      840

tctggctgcc ccgagcgcat gtcttcctgc cgtgggctgg acgatttccg catcgggtgg      900

ggaaccctgg aatacgagac caacgtcacc aacgaggagg acatgaggcc gtactgctgg      960

cattaccctc cgaagccttg cggcattatc tcggctagga cagtttgcgg gccggtctac     1020

tgtttcactc ctagccctgt tgttgtgggt actactgacg agcagggctt gcccacctat     1080

agctgggggg aaaatgagac cgatgtcttc ctgttaaata gcacaagacc cccgcaagga     1140

gcttggttcg gctgcacttg gatgaatggg actgggttta ctaagacatg cggtgcacca     1200

ccttgccgca ttaggaggga tttcaacagc accctcgatc tactgtgccc cacagactgc     1260

tttagaaagc acccggacac cacctatctc aagtgtggag cagggccttg gttaaccccc     1320

agatgcctgg tagactaccc ttatagattg tggcattatc cgtgcaccgt aaattttacc     1380

atctttaagg tgcggatgta tgtggggggg gtggagcatc gattgtcagc agcatgcaac     1440

ttcacgcgcg gggaccgctg cagattggag gacagagata ggggtcagca gagcccactg     1500

ctgcattcca ccactgagtg ggcggtatta ccatgctctt tctccgactt accggcactg     1560

tccactggtc tattgcacct ccatcaaaat atcgtggacg tgcagtatct ctatggactt     1620

actccggcta tcacaaaata catcgtgaag tgggagtggg tggttctcct ctttttgctg     1680

ttggcagacg ccagggtctg tgcgtgcctt tggatgctca tcatattggg ccaagccgaa     1740

gcgtaa                                                                1746


<210>  476
<211>  581
<212>  PRT
<213>  Hepacivirus Hepatitis C Virus

<400>  476

Met Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu 
1               5                   10                  15      


Thr Val Pro Ala Ser Ala Val Glu Val Arg Asn Val Ser Ser Ser Tyr 
            20                  25                  30          


Tyr Ala Thr Asn Asp Cys Ser Asn Ser Ser Ile Thr Trp Gln Leu Asn 
        35                  40                  45              


Asn Ala Val Leu His Leu Pro Gly Cys Val Pro Cys Glu Asn Asp Asn 
    50                  55                  60                  


Gly Thr Leu His Cys Trp Ile Gln Val Thr Pro Asn Val Ala Val Lys 
65                  70                  75                  80  


His Arg Gly Ala Leu Thr His Asn Leu Arg Thr His Val Asp Met Ile 
                85                  90                  95      


Val Met Ala Ala Thr Val Cys Ser Ala Leu Tyr Val Gly Asp Met Cys 
            100                 105                 110         


Gly Ala Val Met Ile Val Ser Gln Ala Leu Ile Ile Ser Pro Glu Arg 
        115                 120                 125             


His Asn Phe Thr Gln Glu Cys Asn Cys Ser Ile Tyr Gln Gly His Ile 
    130                 135                 140                 


Thr Gly His Arg Met Ala Trp Asp Met Met Leu Asn Trp Ser Pro Thr 
145                 150                 155                 160 


Leu Thr Met Ile Leu Ala Tyr Ala Ala Arg Val Pro Glu Leu Val Leu 
                165                 170                 175     


Glu Val Val Phe Gly Gly His Trp Gly Val Val Phe Gly Leu Ala Tyr 
            180                 185                 190         


Phe Ser Met Gln Gly Ala Trp Ala Lys Val Ile Ala Ile Leu Leu Leu 
        195                 200                 205             


Val Ala Gly Val Asp Ala Glu Thr His Thr Thr Gly Ser Ala Ala Gly 
    210                 215                 220                 


His Ala Ala Arg Gly Phe Ala Asn Leu Leu Ser Pro Gly Ser Lys Gln 
225                 230                 235                 240 


Lys Ile Ser Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr 
                245                 250                 255     


Ala Leu Asn Cys Asn Asp Ser Leu Gln Thr Gly Phe Leu Ala Ser Leu 
            260                 265                 270         


Phe Tyr Val Asn Asn Phe Asn Ser Ser Gly Cys Pro Glu Arg Met Ser 
        275                 280                 285             


Ser Cys Arg Gly Leu Asp Asp Phe Arg Ile Gly Trp Gly Thr Leu Glu 
    290                 295                 300                 


Tyr Glu Thr Asn Val Thr Asn Glu Glu Asp Met Arg Pro Tyr Cys Trp 
305                 310                 315                 320 


His Tyr Pro Pro Lys Pro Cys Gly Ile Ile Ser Ala Arg Thr Val Cys 
                325                 330                 335     


Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr 
            340                 345                 350         


Asp Glu Gln Gly Leu Pro Thr Tyr Ser Trp Gly Glu Asn Glu Thr Asp 
        355                 360                 365             


Val Phe Leu Leu Asn Ser Thr Arg Pro Pro Gln Gly Ala Trp Phe Gly 
    370                 375                 380                 


Cys Thr Trp Met Asn Gly Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro 
385                 390                 395                 400 


Pro Cys Arg Ile Arg Arg Asp Phe Asn Ser Thr Leu Asp Leu Leu Cys 
                405                 410                 415     


Pro Thr Asp Cys Phe Arg Lys His Pro Asp Thr Thr Tyr Leu Lys Cys 
            420                 425                 430         


Gly Ala Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr 
        435                 440                 445             


Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Ile Phe Lys Val 
    450                 455                 460                 


Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Ser Ala Ala Cys Asn 
465                 470                 475                 480 


Phe Thr Arg Gly Asp Arg Cys Arg Leu Glu Asp Arg Asp Arg Gly Gln 
                485                 490                 495     


Gln Ser Pro Leu Leu His Ser Thr Thr Glu Trp Ala Val Leu Pro Cys 
            500                 505                 510         


Ser Phe Ser Asp Leu Pro Ala Leu Ser Thr Gly Leu Leu His Leu His 
        515                 520                 525             


Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Leu Thr Pro Ala Ile 
    530                 535                 540                 


Thr Lys Tyr Ile Val Lys Trp Glu Trp Val Val Leu Leu Phe Leu Leu 
545                 550                 555                 560 


Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp Met Leu Ile Ile Leu 
                565                 570                 575     


Gly Gln Ala Glu Ala 
            580     


<210>  477
<211>  1575
<212>  DNA
<213>  Lyssavirus Rabies Virus

<400>  477
atggttcctc aggctctcct gtttgtaccc cttctggttt ttccattgtg ttttgggaaa       60

ttccctattt acacgatacc agacaagctt ggtccctgga gtccgattga catacatcac      120

ctcagctgcc caaacaattt ggtagtggag gacgaaggat gcaccaacct gtcagggttc      180

tcctacatgg aacttaaagt tggatacatc ttagccataa aagtgaacgg gttcacttgc      240

acaggcgttg tgacggaggc tgaaacctac actaacttcg ttggttatgt cacaaccacg      300

ttcaaaagaa agcatttccg cccaacacca gatgcatgta gagccgcgta caactggaag      360

atggccggtg accccagata tgaagagtct ctacacaatc cgtaccctga ctaccgctgg      420

cttcgaactg taaaaaccac caaggagtct ctcgttatca tatctccaag tgtggcagat      480

ttggacccat atgacagatc ccttcactcg agggtcttcc ctagcgggaa gtgctcagga      540

gtagcggtgt cttctaccta ctgctccact aaccacgatt acaccatttg gatgcccgag      600

aatccgagac tagggatgtc ttgtgacatt tttaccaata gtagagggaa gagagcatcc      660

aaagggagtg agacttgcgg ctttgtagat gaaagaggcc tatataagtc tttaaaagga      720

gcatgcaaac tcaagttatg tggagttcta ggacttagac ttatggatgg aacatgggtc      780

tcgatgcaaa catcaaatga aaccaaatgg tgccctcccg ataagttggt gaacctgcac      840

gactttcgct cagacgaaat tgagcacctt gttgtagagg agttggtcag gaagagagag      900

gagtgtctgg atgcactaga gtccatcatg acaaccaagt cagtgagttt cagacgtctc      960

agtcatttaa gaaaacttgt ccctgggttt ggaaaagcat ataccatatt caacaagacc     1020

ttgatggaag ccgatgctca ctacaagtca gtcagaactt ggaatgagat cctcccttca     1080

aaagggtgtt taagagttgg ggggaggtgt catcctcatg tgaacggggt gtttttcaat     1140

ggtataatat taggacctga cggcaatgtc ttaatcccag agatgcaatc atccctcctc     1200

cagcaacata tggagttgtt ggaatcctcg gttatccccc ttgtgcaccc cctggcagac     1260

ccgtctaccg ttttcaagga cggtgacgag gctgaggatt ttgttgaagt tcaccttccc     1320

gatgtgcaca atcaggtctc aggagttgac ttgggtctcc cgaactgggg gaagtatgta     1380

ttactgagtg caggggccct gactgccttg atgttgataa ttttcctgat gacatgttgt     1440

agaagagtca atcgatcaga acctacgcaa cacaatctca gagggacagg gagggaggtg     1500

tcagtcactc cccaaagcgg gaagatcata tcttcatggg aatcacacaa gagtgggggt     1560

gagaccagac tgtaa                                                      1575


<210>  478
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies Virus

<400>  478

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Lys Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  479
<211>  1569
<212>  DNA
<213>  Lyssavirus Mokola Virus

<400>  479
atgaatatac cttgctttgt tgtgattctc agcttagcca ctacacattc tctgggagaa       60

ttccccttgt acacaattcc tgagaagata gagaaatgga ctcccataga catgatccat      120

ctgagttgcc ccaacaacct attatctgag gaagaaggtt gcaatgcaga gtcatccttt      180

acttactttg agctcaagag tggttaccta gctcatcaga aggttccagg gtttacctgt      240

accggggtcg tgaacgaggc agagacatat acaaacttcg tcgggtacgt caccacaacc      300

ttcaaaagga agcactttag gcctacagta gccgcctgtc gtgatgccta caactggaaa      360

gtgtcaggag accccaggta cgaagagtca ctccacactc cttatcctga cagcagttgg      420

ttgaggactg tgactacaac caaagaatca cttctcataa tatcgcccag catcgtggaa      480

atggatattt acggcaggac tctccattcc cccatgtttc cttcaggagt atgttccaac      540

gtatatccct ctgtcccatc ctgtgagact aatcatgatt acacattatg gctgcctgaa      600

gatcctagtt tgagtttggt ctgtgatatc tttacttcca gcaacggaaa gaaggccatg      660

aacgggtcac gcatctgcgg attcaaggat gaaaggggat tctacagatc tttaaagggc      720

gcttgcaagc tgacattgtg tggaagacct ggaattaggt tattcgacgg aacttgggtc      780

tcttttacaa agccggacgt gcacgtatgg tgcactccca accaattgat caatatacac      840

aatgacagac tagatgagat agaacacctg atcgtggaag acatcataaa gaaaagagaa      900

gagtgcttag acaccctgga aacaatactt atgtctcaat ctgttagctt tagaaggttg      960

agccatttcc gaaagttagt tccaggatat gggaaggcct acactatttt aaacggcagc     1020

ctgatggaaa caaatgtcta ctacaaaagg gtcgacaagt gggctgacat cttaccctct     1080

aagggatgtc tgaaagtcgg gcaacaatgc atggaacctg tcaaaggagt cctcttcaat     1140

gggattatca agggcccgga tggccaaatt ttgatccccg agatgcagtc agagcagcta     1200

aagcagcata tggacctgtt gaaggcggct gtgtttcctc tccgacaccc tttaatcagc     1260

cgggaggcag tctttaagaa agacggggat gccgatgatt ttgtggatct ccatatgcct     1320

gatgtccaca agtctgtgtc agatgtcgac ctgggtctgc ctcattgggg tttctggatg     1380

ttgatcgggg caacaatagt agcatttgtg gtcttggtat gtttactccg tgtatgttgt     1440

aagagagtga ggaggagaag atcaggacgt gcaactcagg agatccccct gagctttccc     1500

tctgcccctg ttcctcgagc caaagtggtg tcatcttggg agtcctataa agggcttcca     1560

ggtacatga                                                             1569


<210>  480
<211>  522
<212>  PRT
<213>  Lyssavirus Mokola Virus

<400>  480

Met Asn Ile Pro Cys Phe Val Val Ile Leu Ser Leu Ala Thr Thr His 
1               5                   10                  15      


Ser Leu Gly Glu Phe Pro Leu Tyr Thr Ile Pro Glu Lys Ile Glu Lys 
            20                  25                  30          


Trp Thr Pro Ile Asp Met Ile His Leu Ser Cys Pro Asn Asn Leu Leu 
        35                  40                  45              


Ser Glu Glu Glu Gly Cys Asn Ala Glu Ser Ser Phe Thr Tyr Phe Glu 
    50                  55                  60                  


Leu Lys Ser Gly Tyr Leu Ala His Gln Lys Val Pro Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Asn Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Val Ala Ala 
            100                 105                 110         


Cys Arg Asp Ala Tyr Asn Trp Lys Val Ser Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Thr Pro Tyr Pro Asp Ser Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Thr Thr Thr Lys Glu Ser Leu Leu Ile Ile Ser Pro Ser Ile Val Glu 
145                 150                 155                 160 


Met Asp Ile Tyr Gly Arg Thr Leu His Ser Pro Met Phe Pro Ser Gly 
                165                 170                 175     


Val Cys Ser Asn Val Tyr Pro Ser Val Pro Ser Cys Glu Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Leu Trp Leu Pro Glu Asp Pro Ser Leu Ser Leu Val Cys 
        195                 200                 205             


Asp Ile Phe Thr Ser Ser Asn Gly Lys Lys Ala Met Asn Gly Ser Arg 
    210                 215                 220                 


Ile Cys Gly Phe Lys Asp Glu Arg Gly Phe Tyr Arg Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Thr Leu Cys Gly Arg Pro Gly Ile Arg Leu Phe Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Phe Thr Lys Pro Asp Val His Val Trp Cys Thr 
            260                 265                 270         


Pro Asn Gln Leu Ile Asn Ile His Asn Asp Arg Leu Asp Glu Ile Glu 
        275                 280                 285             


His Leu Ile Val Glu Asp Ile Ile Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Thr Leu Glu Thr Ile Leu Met Ser Gln Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Phe Arg Lys Leu Val Pro Gly Tyr Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Leu Asn Gly Ser Leu Met Glu Thr Asn Val Tyr Tyr Lys Arg Val Asp 
            340                 345                 350         


Lys Trp Ala Asp Ile Leu Pro Ser Lys Gly Cys Leu Lys Val Gly Gln 
        355                 360                 365             


Gln Cys Met Glu Pro Val Lys Gly Val Leu Phe Asn Gly Ile Ile Lys 
    370                 375                 380                 


Gly Pro Asp Gly Gln Ile Leu Ile Pro Glu Met Gln Ser Glu Gln Leu 
385                 390                 395                 400 


Lys Gln His Met Asp Leu Leu Lys Ala Ala Val Phe Pro Leu Arg His 
                405                 410                 415     


Pro Leu Ile Ser Arg Glu Ala Val Phe Lys Lys Asp Gly Asp Ala Asp 
            420                 425                 430         


Asp Phe Val Asp Leu His Met Pro Asp Val His Lys Ser Val Ser Asp 
        435                 440                 445             


Val Asp Leu Gly Leu Pro His Trp Gly Phe Trp Met Leu Ile Gly Ala 
    450                 455                 460                 


Thr Ile Val Ala Phe Val Val Leu Val Cys Leu Leu Arg Val Cys Cys 
465                 470                 475                 480 


Lys Arg Val Arg Arg Arg Arg Ser Gly Arg Ala Thr Gln Glu Ile Pro 
                485                 490                 495     


Leu Ser Phe Pro Ser Ala Pro Val Pro Arg Ala Lys Val Val Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Gly Leu Pro Gly Thr 
        515                 520         


<210>  481
<211>  1653
<212>  DNA
<213>  Morbillivirus Measles Virus

<400>  481
atggggctta aggccagtgt ctcagcgata ttcatgacgg tgctccttac gctccagacc       60

cctactgggc agatccattg gggcaacctg tcaaaaatag gtgtcgtagg gatcggctcc      120

gcatcatata aggtgatgac gcggtccagt caccagagct tggtgattaa gttgatgcct      180

aacatcactc ttctgaataa ttgtacgcgg gtggaaatcg cggagtatcg cagactcttg      240

cgcacggtac tcgagcctat tagggatgcg cttaacgcaa tgacgcagaa catcaggcct      300

gtacaatcag tagcatccag caggaggcat aaacgattcg cgggggttgt cctcgcgggg      360

gctgctctcg gtgttgccac cgctgcccaa attacggcgg gtatagcgct ccatcaatca      420

atgctgaata gccaggcgat agataacctg agagcgtcct tggagacaac taatcaggca      480

atcgaaacca ttagacaagc cggacaggaa atgattttgg ccgtccaggg aattcaagat      540

tacatcaata atgaattgat tccttcaatg aaccaattga gttgtgatct gattggccaa      600

aaactcggtt tgaaattgct gaggtactac acggagatcc tctctctttt tggcccatcc      660

ctccgcgatc caatttcagc agaaatctca atccaagctc tgagttatgc tctcggcggc      720

gatatcaaca aagtccttga aaagctcggt tatagtggtg gggacctgtt gggcatactc      780

gagtcccgag ggatcaaagc gcgaattact cacgtcgaca ctgaaagtta cttcatcgtt      840

ctgtctattg cttatcccac gttgagtgaa atcaagggag ttatagtcca ccgcttggag      900

ggcgtttcat ataatattgg ttcccaagag tggtacacga cagtgccaaa atacgttgcg      960

acccagggct atctcatcag caactttgac gagtcatctt gtactttcat gccagaagga     1020

acagtttgtt cacagaatgc cctgtatcct atgagcccgt tgctccaaga atgtctcagg     1080

ggatctacta aatcatgtgc gaggactctt gtaagcgggt cctttggaaa tcggtttatt     1140

cttagtcaag gaaatctcat agcgaactgt gcgagtattt tgtgtaaatg ttacacgacc     1200

ggtacgatca taaatcaaga cccagacaag attctgacct atattgctgc agactattgc     1260

cccgtggtag aggtaaatgg ggtgactata caggttgggt cacgcaaata tcccgatgcc     1320

gtgtacttgc acaggataga tttgggccct cctattagcc tcgaacgcct ggacgtaggg     1380

acgaacctgg gaaatgcggt cgctaagctc gaagacgcaa aagagctgct cgaatcatcc     1440

gatcagatac tgcggagtat gaagggtctg agttccacaa acattgttta cattcttatt     1500

gccgtttgct tggggggtct gattggcata cccactttga tttgttgttg ccgaggtcgc     1560

tgcaacaaaa aaggggggca ggtcggcatg agtcgaccgg gccttaagcc agacttgaca     1620

ggtacgagta aaagttacgt tcgctccctt tag                                  1653


<210>  482
<211>  550
<212>  PRT
<213>  Morbillivirus Measles Virus

<400>  482

Met Gly Leu Lys Ala Ser Val Ser Ala Ile Phe Met Thr Val Leu Leu 
1               5                   10                  15      


Thr Leu Gln Thr Pro Thr Gly Gln Ile His Trp Gly Asn Leu Ser Lys 
            20                  25                  30          


Ile Gly Val Val Gly Ile Gly Ser Ala Ser Tyr Lys Val Met Thr Arg 
        35                  40                  45              


Ser Ser His Gln Ser Leu Val Ile Lys Leu Met Pro Asn Ile Thr Leu 
    50                  55                  60                  


Leu Asn Asn Cys Thr Arg Val Glu Ile Ala Glu Tyr Arg Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Val Leu Glu Pro Ile Arg Asp Ala Leu Asn Ala Met Thr Gln 
                85                  90                  95      


Asn Ile Arg Pro Val Gln Ser Val Ala Ser Ser Arg Arg His Lys Arg 
            100                 105                 110         


Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Met Leu Asn Ser 
    130                 135                 140                 


Gln Ala Ile Asp Asn Leu Arg Ala Ser Leu Glu Thr Thr Asn Gln Ala 
145                 150                 155                 160 


Ile Glu Thr Ile Arg Gln Ala Gly Gln Glu Met Ile Leu Ala Val Gln 
                165                 170                 175     


Gly Ile Gln Asp Tyr Ile Asn Asn Glu Leu Ile Pro Ser Met Asn Gln 
            180                 185                 190         


Leu Ser Cys Asp Leu Ile Gly Gln Lys Leu Gly Leu Lys Leu Leu Arg 
        195                 200                 205             


Tyr Tyr Thr Glu Ile Leu Ser Leu Phe Gly Pro Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ile Ser Ala Glu Ile Ser Ile Gln Ala Leu Ser Tyr Ala Leu Gly Gly 
225                 230                 235                 240 


Asp Ile Asn Lys Val Leu Glu Lys Leu Gly Tyr Ser Gly Gly Asp Leu 
                245                 250                 255     


Leu Gly Ile Leu Glu Ser Arg Gly Ile Lys Ala Arg Ile Thr His Val 
            260                 265                 270         


Asp Thr Glu Ser Tyr Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu 
        275                 280                 285             


Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val Ser Tyr 
    290                 295                 300                 


Asn Ile Gly Ser Gln Glu Trp Tyr Thr Thr Val Pro Lys Tyr Val Ala 
305                 310                 315                 320 


Thr Gln Gly Tyr Leu Ile Ser Asn Phe Asp Glu Ser Ser Cys Thr Phe 
                325                 330                 335     


Met Pro Glu Gly Thr Val Cys Ser Gln Asn Ala Leu Tyr Pro Met Ser 
            340                 345                 350         


Pro Leu Leu Gln Glu Cys Leu Arg Gly Ser Thr Lys Ser Cys Ala Arg 
        355                 360                 365             


Thr Leu Val Ser Gly Ser Phe Gly Asn Arg Phe Ile Leu Ser Gln Gly 
    370                 375                 380                 


Asn Leu Ile Ala Asn Cys Ala Ser Ile Leu Cys Lys Cys Tyr Thr Thr 
385                 390                 395                 400 


Gly Thr Ile Ile Asn Gln Asp Pro Asp Lys Ile Leu Thr Tyr Ile Ala 
                405                 410                 415     


Ala Asp Tyr Cys Pro Val Val Glu Val Asn Gly Val Thr Ile Gln Val 
            420                 425                 430         


Gly Ser Arg Lys Tyr Pro Asp Ala Val Tyr Leu His Arg Ile Asp Leu 
        435                 440                 445             


Gly Pro Pro Ile Ser Leu Glu Arg Leu Asp Val Gly Thr Asn Leu Gly 
    450                 455                 460                 


Asn Ala Val Ala Lys Leu Glu Asp Ala Lys Glu Leu Leu Glu Ser Ser 
465                 470                 475                 480 


Asp Gln Ile Leu Arg Ser Met Lys Gly Leu Ser Ser Thr Asn Ile Val 
                485                 490                 495     


Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile Pro Thr 
            500                 505                 510         


Leu Ile Cys Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Gly Gln Val 
        515                 520                 525             


Gly Met Ser Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys 
    530                 535                 540                 


Ser Tyr Val Arg Ser Leu 
545                 550 


<210>  483
<211>  1854
<212>  DNA
<213>  Morbillivirus Measles Virus

<400>  483
atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca tcccaaggga       60

agtaggatag ttattaatag agaacatctt atgattgata gaccttatgt tttgctggct      120

gttctattcg tcatgtttct gagcttgatc gggttgctag ccattgcagg catcagactt      180

catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa tctagatgta      240

actaactcaa tcgagcatca ggtcaaggac gtgctgacac cactcttcaa aatcatcggt      300

gatgaagtgg gcctgagaac acctcagaga ttcactgacc tagtgaaatt catctctgac      360

aagattaaat tcctcaatcc ggatagggag tacgacttca gagatctcac ttggtgtatc      420

aacccgccag agagaatcaa attggactat gatcaatact gtgcagatgt ggctgctgaa      480

gagctcatga atgcattggt gaactcaact ctactggaga ctaggacaac caatcagttc      540

ctagctgtct caaagggaaa ctgctcaggg cccactacaa tcagaggtca attctcaaac      600

atgtcgttgt ccctgttgga cttgtatttg agtcgaggtt acaatgtgtc atctatagtc      660

actatgacat cccagggaat gtacggggga acttacctag tggaaaagcc taatctgagc      720

agcaaagggt cagagttgcc acaaccaagc atgcaccgag tgtttgaagt aggtgtcatc      780

agaaatccgg gtttgggggc tccggtgttc catatgacaa actattttga gcagccagtc      840

agcaatgatt tcagcaactg tatggtggct ttgggggagc tcaaactcgc agctctttgc      900

cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt cagcttccag      960

ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt ccccttatca     1020

acggatgatc cagtgataga caggctttac ctctcatctc acagaggtat tatcgctgac     1080

aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg aatggagaca     1140

tgcttccagc aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc cgagtgggca     1200

ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttgatct gagcctggca     1260

gttgagctta aaatcaaaat tgcttcagga ttcgggccat tgatcacaca cggttcaggg     1320

atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc gccaatgaag     1380

aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa ggttagtccc     1440

aacctcttta ctgtcccaat taaggaagca ggcgaggact gccatgcccc gacataccta     1500

cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct acctggtcaa     1560

gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc tgtggtttat     1620

tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt gcctataaag     1680

ggagtcccca tcgaattaca agtggaatgc ttcacatggg accaaaaact ctggtgccgt     1740

cacttctgtg tgcttgcaga ctcagaatct ggtggacata tcactcactc tgggatggtg     1800

ggtatgggag tcagctgcac agtcactcgg gaagatggaa ccaaccgcgg atag           1854


<210>  484
<211>  617
<212>  PRT
<213>  Morbillivirus Measles Virus

<400>  484

Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 
            20                  25                  30          


Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser 
        35                  40                  45              


Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile Arg Leu His Arg Ala Ala 
    50                  55                  60                  


Ile Tyr Thr Ala Glu Ile His Lys Ser Leu Ser Thr Asn Leu Asp Val 
65                  70                  75                  80  


Thr Asn Ser Ile Glu His Gln Val Lys Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Thr Pro Gln Arg Phe Thr 
            100                 105                 110         


Asp Leu Val Lys Phe Ile Ser Asp Lys Ile Lys Phe Leu Asn Pro Asp 
        115                 120                 125             


Arg Glu Tyr Asp Phe Arg Asp Leu Thr Trp Cys Ile Asn Pro Pro Glu 
    130                 135                 140                 


Arg Ile Lys Leu Asp Tyr Asp Gln Tyr Cys Ala Asp Val Ala Ala Glu 
145                 150                 155                 160 


Glu Leu Met Asn Ala Leu Val Asn Ser Thr Leu Leu Glu Thr Arg Thr 
                165                 170                 175     


Thr Asn Gln Phe Leu Ala Val Ser Lys Gly Asn Cys Ser Gly Pro Thr 
            180                 185                 190         


Thr Ile Arg Gly Gln Phe Ser Asn Met Ser Leu Ser Leu Leu Asp Leu 
        195                 200                 205             


Tyr Leu Ser Arg Gly Tyr Asn Val Ser Ser Ile Val Thr Met Thr Ser 
    210                 215                 220                 


Gln Gly Met Tyr Gly Gly Thr Tyr Leu Val Glu Lys Pro Asn Leu Ser 
225                 230                 235                 240 


Ser Lys Gly Ser Glu Leu Pro Gln Pro Ser Met His Arg Val Phe Glu 
                245                 250                 255     


Val Gly Val Ile Arg Asn Pro Gly Leu Gly Ala Pro Val Phe His Met 
            260                 265                 270         


Thr Asn Tyr Phe Glu Gln Pro Val Ser Asn Asp Phe Ser Asn Cys Met 
        275                 280                 285             


Val Ala Leu Gly Glu Leu Lys Leu Ala Ala Leu Cys His Gly Glu Asp 
    290                 295                 300                 


Ser Ile Thr Ile Pro Tyr Gln Gly Ser Gly Lys Gly Val Ser Phe Gln 
305                 310                 315                 320 


Leu Val Lys Leu Gly Val Trp Lys Ser Pro Thr Asp Met Gln Ser Trp 
                325                 330                 335     


Val Pro Leu Ser Thr Asp Asp Pro Val Ile Asp Arg Leu Tyr Leu Ser 
            340                 345                 350         


Ser His Arg Gly Ile Ile Ala Asp Asn Gln Ala Lys Trp Ala Val Pro 
        355                 360                 365             


Thr Thr Arg Thr Asp Asp Lys Leu Arg Met Glu Thr Cys Phe Gln Gln 
    370                 375                 380                 


Ala Cys Lys Gly Lys Ile Gln Ala Leu Cys Glu Asn Pro Glu Trp Ala 
385                 390                 395                 400 


Pro Leu Lys Asp Asn Arg Ile Pro Ser Tyr Gly Val Leu Ser Val Asp 
                405                 410                 415     


Leu Ser Leu Ala Val Glu Leu Lys Ile Lys Ile Ala Ser Gly Phe Gly 
            420                 425                 430         


Pro Leu Ile Thr His Gly Ser Gly Met Asp Leu Tyr Lys Ser Asn His 
        435                 440                 445             


Asn Asn Val Tyr Trp Leu Thr Ile Pro Pro Met Lys Asn Leu Ala Leu 
    450                 455                 460                 


Gly Val Ile Asn Thr Leu Glu Trp Ile Pro Arg Phe Lys Val Ser Pro 
465                 470                 475                 480 


Asn Leu Phe Thr Val Pro Ile Lys Glu Ala Gly Glu Asp Cys His Ala 
                485                 490                 495     


Pro Thr Tyr Leu Pro Ala Glu Val Asp Gly Asp Val Lys Leu Ser Ser 
            500                 505                 510         


Asn Leu Val Ile Leu Pro Gly Gln Asp Leu Gln Tyr Val Leu Ala Thr 
        515                 520                 525             


Tyr Asp Thr Ser Arg Val Glu His Ala Val Val Tyr Tyr Val Tyr Ser 
    530                 535                 540                 


Pro Ser Arg Ser Phe Ser Tyr Phe Tyr Pro Phe Arg Leu Pro Ile Lys 
545                 550                 555                 560 


Gly Val Pro Ile Glu Leu Gln Val Glu Cys Phe Thr Trp Asp Gln Lys 
                565                 570                 575     


Leu Trp Cys Arg His Phe Cys Val Leu Ala Asp Ser Glu Ser Gly Gly 
            580                 585                 590         


His Ile Thr His Ser Gly Met Val Gly Met Gly Val Ser Cys Thr Val 
        595                 600                 605             


Thr Arg Glu Asp Gly Thr Asn Arg Gly 
    610                 615         


<210>  485
<211>  2031
<212>  DNA
<213>  Ebolavirus Ebola Zaire Virus

<400>  485
atgggcgtta caggaatatt gcagttacct cgtgatcgat tcaagaggac atcattcttt       60

ctttgggtaa ttatcctttt ccaaagaaca ttttccatcc cacttggagt catccacaat      120

agcacattac aggttagtga tgtcgacaaa ctagtttgtc gtgacaaact gtcatccaca      180

aatcaattga gatcagttgg actgaatctc gaagggaatg gagtggcaac tgacgtgcca      240

tctgcaacta aaagatgggg cttcaggtcc ggtgtcccac caaaggtggt caattatgaa      300

gctggtgaat gggctgaaaa ctgctacaat cttgaaatca aaaaacctga cgggagtgag      360

tgtctaccag cagcgccaga cgggattcgg ggcttccccc ggtgccggta tgtgcacaaa      420

gtatcaggaa cgggaccgtg tgccggagac tttgccttcc ataaagaggg tgctttcttc      480

ctgtatgatc gacttgcttc cacagttatc taccgaggaa cgactttcgc tgaaggtgtc      540

gttgcatttc tgatactgcc ccaagctaag aaggacttct tcagctcaca ccccttgaga      600

gagccggtca atgcaacgga ggacccgtct agtggctact attctaccac aattagatat      660

caggctaccg gttttggaac caatgagaca gagtacttgt tcgaggttga caatttgacc      720

tacgtccaac ttgaatcaag attcacacca cagtttctgc tccagctgaa tgagacaata      780

tatacaagtg ggaaaaggag caataccacg ggaaaactaa tttggaaggt caaccccgaa      840

attgatacaa caatcgggga gtgggccttc tgggaaacta aaaaaaacct cactagaaaa      900

attcgcagtg aagagttgtc tttcacagtt gtatcaaacg gagccaaaaa catcagtggt      960

cagagtccgg cgcgaacttc ttccgaccca gggaccaaca caacaactga agaccacaaa     1020

atcatggctt cagaaaattc ctctgcaatg gttcaagtgc acagtcaagg aagggaagct     1080

gcagtgtcgc atctaacaac ccttgccaca atctccacga gtccccaatc cctcacaacc     1140

aaaccaggtc cggacaacag cacccataat acacccgtgt ataaacttga catctctgag     1200

gcaactcaag ttgaacaaca tcaccgcaga acagacaacg acagcacagc ctccgacact     1260

ccctctgcca cgaccgcagc cggaccccca aaagcagaga acaccaacac gagcaagagc     1320

actgacttcc tggaccccgc caccacaaca agtccccaaa accacagcga gaccgctggc     1380

aacaacaaca ctcatcacca agataccgga gaagagagtg ccagcagcgg gaagctaggc     1440

ttaattacca atactattgc tggagtcgca ggactgatca caggcgggag aagaactcga     1500

agagaagcaa ttgtcaatgc tcaacccaaa tgcaacccta atttacatta ctggactact     1560

caggatgaag gtgctgcaat cggactggcc tggataccat atttcgggcc agcagccgag     1620

ggaatttaca tagaggggct aatgcacaat caagatggtt taatctgtgg gttgagacag     1680

ctggccaacg agacgactca agctcttcaa ctgttcctga gagccacaac tgagctacgc     1740

accttttcaa tcctcaaccg taaggcaatt gatttcttgc tgcagcgatg gggcggcaca     1800

tgccacattc tgggaccgga ctgctgtatc gaaccacatg attggaccaa gaacataaca     1860

gacaaaattg atcagattat tcatgatttt gttgataaaa cccttccgga ccagggggac     1920

aatgacaatt ggtggacagg atggagacaa tggataccgg caggtattgg agttacaggc     1980

gttataattg cagttatcgc tttattctgt atatgcaaat ttgtctttta g              2031


<210>  486
<211>  676
<212>  PRT
<213>  Ebolavirus Ebola Zaire Virus

<400>  486

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  487
<211>  1485
<212>  DNA
<213>  Flavivirus Dengue Virus

<400>  487
atgcggtgcg tgggaatagg aaacagagac ttcgtggaag gactgtcagg agctacgtgg       60

gtggatgtag ttctggagca tggaagttgc gtcactacca tggcaaaaga caaaccaaca      120

ctggacattg aactcctgaa gacggaggtc acaaaccctg ccgtcctgcg caaactgtgt      180

atagaagcta aaatatcaaa taccaccact gactcgagat gtccgacaca aggagaagcc      240

acgctggtgg aagaacaaga cacgaacttt gtgtgtcgac gaacattcgt ggacagaggc      300

tggggcaatg gttgtggact attcggaaag ggtagcttaa taacgtgtgc taagtttaag      360

tgtgtgacaa aattggaagg aaagatagtc caatatgaaa acttaaaata ttctgtgatc      420

gttaccgtcc acactggaga ccagcaccaa gttggaaatg agaccacaga acatggaaca      480

attgcaacca taacacctca agctcccacg tcggaaatac aactgacaga ctacggagct      540

ctaacactgg attgttcacc tagaacaggg ctagacttta atgagatggt gttgctgaca      600

atgaaagaaa aatcatggct cgtccacaaa caatggtttc tagacttacc actgccttgg      660

acctcagggg cctcaacgtc ccaagagact tggaacagac aagacttgct ggtcacgttt      720

aagacagctc atgcaaagaa gcaggaagta gtcgtactag gatcacaaga aggagcaatg      780

cacactgcgt tgactggagc gacagaaatc caaacgtctg gaacgacaac aatttttgca      840

ggccacctga aatgcagatt aaaaatggac aaactaactc taaaaggaat atcatatgta      900

atgtgcacag gctcattcaa gttagagaag gaagtggctg agacccagca tggaactgtt      960

ctagtacagg tcaaatacga aggaacagat gcaccatgca agatcccctt ctcgtcccaa     1020

gatgagaagg gagtaaccca gaatgggaga ttggtaacag ccaaccccat agtcactgac     1080

aaagaaaaac cagtcaacat tgaagcggag ccaccctttg gtgagagcta catcgtggta     1140

ggagcaggtg aaaaagcttt gaaactaagc tggttcaaga agggaagcag tatagggaaa     1200

atgtttgaag caactgcccg tggagcacga aggatggcca tcctgggaga caccgcatgg     1260

gacttcggct ctataggagg agtgttcacg tctgtgggaa aactggtaca ccagatcttt     1320

ggaactgcgt atggagtttt gttcagcggt gtttcttgga ccatgaaaat aggaataggg     1380

attctgctga catggctggg attaaactca aggagcacgt ccctttcaat gacgtgtatc     1440

gcagttggca tggtcacact gtacctagga gtcatggtcc aggcg                     1485


<210>  488
<211>  495
<212>  PRT
<213>  Flavivirus Dengue Virus

<400>  488

Met Arg Cys Val Gly Ile Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asp Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr 
        35                  40                  45              


Glu Val Thr Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys 
    50                  55                  60                  


Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Thr Leu Val Glu Glu Gln Asp Thr Asn Phe Val Cys Arg Arg Thr Phe 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Ile Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly Thr 
145                 150                 155                 160 


Ile Ala Thr Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr 
                165                 170                 175     


Asp Tyr Gly Ala Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Thr Met Lys Glu Lys Ser Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala 
    210                 215                 220                 


Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe 
225                 230                 235                 240 


Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr 
            260                 265                 270         


Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Thr Leu Lys Gly Ile Ser Tyr Val Met Cys Thr Gly 
    290                 295                 300                 


Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val 
305                 310                 315                 320 


Leu Val Gln Val Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Ser Ser Gln Asp Glu Lys Gly Val Thr Gln Asn Gly Arg Leu Val 
            340                 345                 350         


Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Val Gly Ala Gly Glu 
    370                 375                 380                 


Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Lys 
385                 390                 395                 400 


Met Phe Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr Ser Val 
            420                 425                 430         


Gly Lys Leu Val His Gln Ile Phe Gly Thr Ala Tyr Gly Val Leu Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu Leu Thr 
    450                 455                 460                 


Trp Leu Gly Leu Asn Ser Arg Ser Thr Ser Leu Ser Met Thr Cys Ile 
465                 470                 475                 480 


Ala Val Gly Met Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  489
<211>  1518
<212>  DNA
<213>  Flavivirus Zika virus

<400>  489
atgatcaggt gcataggagt cagcaatagg gactttgtgg aaggtatgtc aggtgggact       60

tgggttgatg ttgtcttgga acatggaggt tgtgtcaccg taatggcaca ggacaaaccg      120

actgtcgaca tagagctggt tacaacaaca gtcagcaaca tggcggaggt aagatcctac      180

tgctatgagg catcaatatc agacatggct tcggacagcc gctgcccaac acaaggtgaa      240

gcctaccttg acaagcaatc agacactcaa tatgtctgca aaagaacgtt agtggacaga      300

ggctggggaa atggatgtgg actttttggc aaagggagcc tggtgacatg cgctaagttt      360

gcatgctcca agaaaatgac cgggaagagc atccagccag agaatctgga gtaccggata      420

atgctgtcag ttcatggctc ccagcacagt gggatgatcg ttaatgacac aggacatgaa      480

actgatgaga atagagcgaa ggttgagata acgcccaatt caccaagagc cgaagccacc      540

ctggggggtt ttggaagcct aggacttgat tgtgaaccga ggacaggcct tgacttttca      600

gatttgtatt acttgactat gaataacaag cactggttgg tccacaagga gtggttccac      660

gacattccat taccttggca cgctggggca gacaccggaa ctccacactg gaacaacaaa      720

gaagcactgg tagagttcaa ggacgcacat gccaaaaggc aaactgtcgt ggttctaggg      780

agtcaagaag gagcagttca cacggccctt gctggagctc tggaggctga gatggatggt      840

gcaaagggaa ggctgtcctc tggccacttg aaatgtcgcc tgaaaatgga taaacttaga      900

ttgaagggcg tgtcatactc cttgtgtacc gcagcgttca cattcaccaa gatcccggct      960

gaaacactgc acgggacagt cacagtggag gtacagtacg cagggacaga tggaccttgc     1020

aaggttccag ctcagatggc ggtggacatg caaactctga ccccagttgg gaggttgata     1080

accgctaacc ccgtaatcac tgaaagcact gagaactcta agatgatgct ggaacttgat     1140

ccaccatttg gggactctta cattgtcata ggagtcgggg agaagaagat cacccaccac     1200

tggcacagga gtggcagcac cattggaaaa gcatttgaag ccactgtgag aggtgccaag     1260

agaatggcag tcttgggaga cacagcctgg gactttggat cagttggagg cgctctcaac     1320

tcattgggca agggcatcca tcaaattttt ggagcagctt tcaaatcatt gtttggagga     1380

atgtcctggt tctcacaaat cctcattgga acgttgctga tgtggttggg tctgaacaca     1440

aagaatggat ctatttccct tatgtgcttg gccttagggg gagtgttgat cttcttatcc     1500

acagccgtct ctgcttag                                                   1518


<210>  490
<211>  505
<212>  PRT
<213>  Flavivirus Zika virus

<400>  490

Met Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met 
1               5                   10                  15      


Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val 
            20                  25                  30          


Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr 
        35                  40                  45              


Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala 
    50                  55                  60                  


Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu 
65                  70                  75                  80  


Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr 
                85                  90                  95      


Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
            100                 105                 110         


Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly 
        115                 120                 125             


Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val 
    130                 135                 140                 


His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu 
145                 150                 155                 160 


Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg 
                165                 170                 175     


Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu 
            180                 185                 190         


Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn 
        195                 200                 205             


Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu 
    210                 215                 220                 


Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys 
225                 230                 235                 240 


Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val 
                245                 250                 255     


Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly 
            260                 265                 270         


Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly 
        275                 280                 285             


His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val 
    290                 295                 300                 


Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala 
305                 310                 315                 320 


Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr 
                325                 330                 335     


Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr 
            340                 345                 350         


Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu 
        355                 360                 365             


Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly 
    370                 375                 380                 


Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His 
385                 390                 395                 400 


Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val 
                405                 410                 415     


Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe 
            420                 425                 430         


Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln 
        435                 440                 445             


Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe 
    450                 455                 460                 


Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr 
465                 470                 475                 480 


Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu 
                485                 490                 495     


Ile Phe Leu Ser Thr Ala Val Ser Ala 
            500                 505 


<210>  491
<211>  1284
<212>  DNA
<213>  Flavivirus West Nile Virus

<400>  491
atgttcaact gccttggaat gagcaacaga gacttcttgg aaggagtgtc tggagcaaca       60

tgggtggatt tggttctcga aggcgacagc tgcgtgacta tcatgtctaa ggacaagcct      120

accatcgatg tgaagatgat gaatatggag gcggccaacc tggcagaggt ccgcagttat      180

tgctatttgg ctaccgtcag cgatctctcc accaaagctg cgtgcccgac catgggagaa      240

gctcacaatg acaaacgtgc tgacccagct tttgtgtgca gacaaggagt ggtggacagg      300

ggctggggca acggctgcgg actatttggc aaaggaagca ttgacacatg cgccaaattt      360

gcctgctcta ccaaggcaat aggaagaacc atcttgaaag agaatatcaa gtacgaagtg      420

gccatttttg tccatggacc aactactgtg gagtcgcacg gaaactactc cacacaggtt      480

ggagccactc aggcagggag attcagcatc actcctgcgg cgccttcata cacactaaag      540

cttggagaat atggagaggt gacagtggac tgtgaaccac ggtcagggat tgacaccaat      600

gcatactacg tgatgactgt tggaacaaag acgttcttgg tccatcgtga gtggttcatg      660

gacctcaacc tcccttggag cagtgctgga agtactgtgt ggaggaacag agagacgtta      720

atggagtttg aagaaccaca cgccacgaag cagtctgtga tagcattggg ctcacaagag      780

ggagctctgc atcaagcttt ggctggagcc attcctgtgg aattttcaag caacactgtc      840

aagttgacgt cgggtcattt gaagtgtaga gtgaagatgg aaaaattgca gttgaaggga      900

acaacctatg gcgtctgttc aaaggctttc aagtttcttg ggactcccgc agacacaggt      960

cacggcactg tggtgttgga attgcagtac actggcacgg atggaccttg caaagttcct     1020

atctcgtcag tggcttcatt gaacgaccta acgccagtgg gcagattggt cactgtcaac     1080

ccttttgttt cagtggccac ggccaacgct aaggtcctga ttgaattgga accacccttt     1140

ggagactcat acatagtggt gggcagagga gaacaacaga tcaatcacca ttggcacaag     1200

tctggaagca gcattggcaa agcctttaca accaccctca aaggagcgca gagactagcc     1260

gctctaggag acacagcttg gtag                                            1284


<210>  492
<211>  427
<212>  PRT
<213>  Flavivirus West Nile Virus

<400>  492

Met Phe Asn Cys Leu Gly Met Ser Asn Arg Asp Phe Leu Glu Gly Val 
1               5                   10                  15      


Ser Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Val 
            20                  25                  30          


Thr Ile Met Ser Lys Asp Lys Pro Thr Ile Asp Val Lys Met Met Asn 
        35                  40                  45              


Met Glu Ala Ala Asn Leu Ala Glu Val Arg Ser Tyr Cys Tyr Leu Ala 
    50                  55                  60                  


Thr Val Ser Asp Leu Ser Thr Lys Ala Ala Cys Pro Thr Met Gly Glu 
65                  70                  75                  80  


Ala His Asn Asp Lys Arg Ala Asp Pro Ala Phe Val Cys Arg Gln Gly 
                85                  90                  95      


Val Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
            100                 105                 110         


Ser Ile Asp Thr Cys Ala Lys Phe Ala Cys Ser Thr Lys Ala Ile Gly 
        115                 120                 125             


Arg Thr Ile Leu Lys Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe Val 
    130                 135                 140                 


His Gly Pro Thr Thr Val Glu Ser His Gly Asn Tyr Ser Thr Gln Val 
145                 150                 155                 160 


Gly Ala Thr Gln Ala Gly Arg Phe Ser Ile Thr Pro Ala Ala Pro Ser 
                165                 170                 175     


Tyr Thr Leu Lys Leu Gly Glu Tyr Gly Glu Val Thr Val Asp Cys Glu 
            180                 185                 190         


Pro Arg Ser Gly Ile Asp Thr Asn Ala Tyr Tyr Val Met Thr Val Gly 
        195                 200                 205             


Thr Lys Thr Phe Leu Val His Arg Glu Trp Phe Met Asp Leu Asn Leu 
    210                 215                 220                 


Pro Trp Ser Ser Ala Gly Ser Thr Val Trp Arg Asn Arg Glu Thr Leu 
225                 230                 235                 240 


Met Glu Phe Glu Glu Pro His Ala Thr Lys Gln Ser Val Ile Ala Leu 
                245                 250                 255     


Gly Ser Gln Glu Gly Ala Leu His Gln Ala Leu Ala Gly Ala Ile Pro 
            260                 265                 270         


Val Glu Phe Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His Leu Lys 
        275                 280                 285             


Cys Arg Val Lys Met Glu Lys Leu Gln Leu Lys Gly Thr Thr Tyr Gly 
    290                 295                 300                 


Val Cys Ser Lys Ala Phe Lys Phe Leu Gly Thr Pro Ala Asp Thr Gly 
305                 310                 315                 320 


His Gly Thr Val Val Leu Glu Leu Gln Tyr Thr Gly Thr Asp Gly Pro 
                325                 330                 335     


Cys Lys Val Pro Ile Ser Ser Val Ala Ser Leu Asn Asp Leu Thr Pro 
            340                 345                 350         


Val Gly Arg Leu Val Thr Val Asn Pro Phe Val Ser Val Ala Thr Ala 
        355                 360                 365             


Asn Ala Lys Val Leu Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr 
    370                 375                 380                 


Ile Val Val Gly Arg Gly Glu Gln Gln Ile Asn His His Trp His Lys 
385                 390                 395                 400 


Ser Gly Ser Ser Ile Gly Lys Ala Phe Thr Thr Thr Leu Lys Gly Ala 
                405                 410                 415     


Gln Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp 
            420                 425         


<210>  493
<211>  1506
<212>  DNA
<213>  Flavivirus Japanese Encephalitis Virus

<400>  493
atgttcaact gtctgggaat gggcaatcgt gacttcatag aaggagccag tggagccact       60

tgggtggact tggtgctaga aggagatagc tgcttgacaa tcatggcaaa cgacaaacca      120

acattggacg tccgcatgat taacatcgaa gctagtcaac ttgctgaggt cagaagttac      180

tgctatcatg cttcagtcac tgacatctcg acggtggctc ggtgccccac gactggagaa      240

gcccacaacg agaagcgagc tgatagtagc tatgtgtgca aacaaggctt cactgatcgt      300

gggtggggca acggatgtgg actcttcggg aaggggagca ttgacacatg tgcaaaattc      360

tcctgcacta gcaaagcgat tgggagaaca atccagccag aaaacatcaa atacgaagtt      420

ggcatttttg tgcatggaac caccacttca gaaaaccatg ggaattattc agcgcaagtt      480

ggggcttccc aggcggcaaa gtttacagta acacccaatg ctccttcgat aaccctcaaa      540

cttggtgact acggagaagt cacgctggac tgtgagccaa ggagtggact gaacactgaa      600

gcgttttacg tcatgaccgt ggggtcaaag tcatttctgg tccataggga atggtttcat      660

gacctcgctc tcccctggac gtctccttcg agcacagcgt ggagaaacag agaactcctc      720

atggaatttg aagaagcgca cgccacaaaa cagtccgttg ttgctcttgg gtcacaggaa      780

ggaggcctcc atcaggcgct ggcaggggcc attgtggtgg agtactcaag ctcagtaaag      840

ctaacatcag gccacctgaa atgcaggcta aaaatggaca aactggccct gaaaggcaca      900

acctatggca tgtgtacagg aaaattctcg ttcgcgaaaa atccggcgga cactggccac      960

ggaacagttg tcattgaact ctcctactct gggagagacg gcccctgcaa aattccgatt     1020

gtctccgttg cgagccttaa tgacatgact cccgttgggc ggctggtgac agtgaaccct     1080

ttcgtcgcga cttccagtgc taactcaaag gtgctggtcg agatggaacc ccctttcgga     1140

gactcctaca tcgtggttgg gaggggagac aagcagatta accaccattg gcacaaagct     1200

ggaagcacgc taggcaaggc cttttcaaca actttgaagg gggctcaaag gctggcagcg     1260

ttgggcgaca cagcctggga ctttggctct attggagggg tcttcaactc cataggaaaa     1320

gccgtccacc aagtgtttgg tggtgccttc agaacactct tcgggggaat gtcttggatc     1380

acacaagggc taatgggtgc cctactgctt tggatgggcg tcaacgcacg agaccgatca     1440

attgctctgg ccttcttagc cacaggaggt gtgctcgtgt tcttagcgac caatgtgcat     1500

gcttag                                                                1506


<210>  494
<211>  501
<212>  PRT
<213>  Flavivirus Japanese Encephalitis Virus

<400>  494

Met Phe Asn Cys Leu Gly Met Gly Asn Arg Asp Phe Ile Glu Gly Ala 
1               5                   10                  15      


Ser Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Leu 
            20                  25                  30          


Thr Ile Met Ala Asn Asp Lys Pro Thr Leu Asp Val Arg Met Ile Asn 
        35                  40                  45              


Ile Glu Ala Ser Gln Leu Ala Glu Val Arg Ser Tyr Cys Tyr His Ala 
    50                  55                  60                  


Ser Val Thr Asp Ile Ser Thr Val Ala Arg Cys Pro Thr Thr Gly Glu 
65                  70                  75                  80  


Ala His Asn Glu Lys Arg Ala Asp Ser Ser Tyr Val Cys Lys Gln Gly 
                85                  90                  95      


Phe Thr Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
            100                 105                 110         


Ser Ile Asp Thr Cys Ala Lys Phe Ser Cys Thr Ser Lys Ala Ile Gly 
        115                 120                 125             


Arg Thr Ile Gln Pro Glu Asn Ile Lys Tyr Glu Val Gly Ile Phe Val 
    130                 135                 140                 


His Gly Thr Thr Thr Ser Glu Asn His Gly Asn Tyr Ser Ala Gln Val 
145                 150                 155                 160 


Gly Ala Ser Gln Ala Ala Lys Phe Thr Val Thr Pro Asn Ala Pro Ser 
                165                 170                 175     


Ile Thr Leu Lys Leu Gly Asp Tyr Gly Glu Val Thr Leu Asp Cys Glu 
            180                 185                 190         


Pro Arg Ser Gly Leu Asn Thr Glu Ala Phe Tyr Val Met Thr Val Gly 
        195                 200                 205             


Ser Lys Ser Phe Leu Val His Arg Glu Trp Phe His Asp Leu Ala Leu 
    210                 215                 220                 


Pro Trp Thr Ser Pro Ser Ser Thr Ala Trp Arg Asn Arg Glu Leu Leu 
225                 230                 235                 240 


Met Glu Phe Glu Glu Ala His Ala Thr Lys Gln Ser Val Val Ala Leu 
                245                 250                 255     


Gly Ser Gln Glu Gly Gly Leu His Gln Ala Leu Ala Gly Ala Ile Val 
            260                 265                 270         


Val Glu Tyr Ser Ser Ser Val Lys Leu Thr Ser Gly His Leu Lys Cys 
        275                 280                 285             


Arg Leu Lys Met Asp Lys Leu Ala Leu Lys Gly Thr Thr Tyr Gly Met 
    290                 295                 300                 


Cys Thr Gly Lys Phe Ser Phe Ala Lys Asn Pro Ala Asp Thr Gly His 
305                 310                 315                 320 


Gly Thr Val Val Ile Glu Leu Ser Tyr Ser Gly Arg Asp Gly Pro Cys 
                325                 330                 335     


Lys Ile Pro Ile Val Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val 
            340                 345                 350         


Gly Arg Leu Val Thr Val Asn Pro Phe Val Ala Thr Ser Ser Ala Asn 
        355                 360                 365             


Ser Lys Val Leu Val Glu Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 


Val Val Gly Arg Gly Asp Lys Gln Ile Asn His His Trp His Lys Ala 
385                 390                 395                 400 


Gly Ser Thr Leu Gly Lys Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln 
                405                 410                 415     


Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly 
            420                 425                 430         


Gly Val Phe Asn Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly 
        435                 440                 445             


Ala Phe Arg Thr Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu 
    450                 455                 460                 


Met Gly Ala Leu Leu Leu Trp Met Gly Val Asn Ala Arg Asp Arg Ser 
465                 470                 475                 480 


Ile Ala Leu Ala Phe Leu Ala Thr Gly Gly Val Leu Val Phe Leu Ala 
                485                 490                 495     


Thr Asn Val His Ala 
            500     


<210>  495
<211>  2179
<212>  DNA
<213>  Pegivirus Hepatitis G Virus

<400>  495
gcaaagcacg tgagatcgcc accatgtcac ttctcacgaa ccgctttatt cggcgagtag       60

ataaagacca atggggccca ggtgtgatgg gtaaagatcc caaaccttgt cctagccgct      120

gggcaggaaa gtgtatgggc ccaccaagct ccgccgcagc atgtagtcgc ggcagcccgc      180

gtatacttcg tgttcgggcg ggtggtattt ccttgttcta tacgataatg gctgtgctcc      240

tgctgctcct tgttgtcgaa gcgggtgcta tactggcccc agctacccat gcatgccgcg      300

cgaatggaca gtattttctg acaaattgct gtgcaccgga agacataggg ttttgtctcg      360

aaggtggctg tctcgtcgct ttgggctgca cagtttgtac tgatcggtgt tggccgctgt      420

atcaagcagg ccttgctgtg cgccctggga aaagcgctgc acagctggtt ggagagttgg      480

ggagcctgta cggccccctt tctgtctctg cctacgtggc gggcatattg ggtctgggtg      540

aggtctattc tggagttttg acggtcggtg ttgccctcag gcgaagagtc tatctgatgc      600

ctaatctcaa atgtgcagtg gaatgcgatg tcaagtgggg aagcgagttc tggagatgga      660

cggagcaact ggccagcaac tactggattc ttgaatatct gtggaaagtc cctttcgaat      720

tttggagagg cgtaatgtcc cttacacccc tgctcgtgtg ggtggccgcg ttgctccttc      780

tggagcaacg gatcgtgatg gttttccttc tggttacaat ggcagggatg ctccaaggtg      840

caccagcatc agtgctcgga tcaagacctt tcgactacgg gctgaaatgg cagtcctgta      900

gttgccgagc aaatggctcc aggatcccaa ctggtgaaag ggtatgggac cggggtaacg      960

tgacactgct gtgcgattgc ccaaatggac cgtgggtgtg ggtccccgcc ttttgtcagg     1020

cagtaggctg gggagatcca ataactcatt ggtcccacgg gcaaaaccaa tggcctttgt     1080

cctgtccgca atatgtatat ggctcagtgt cagtgacttg tgtttggggc tcagtctcct     1140

ggttcgcttc cacgggcggc agagattcca aaatagatgt ctggtctctt gtaccagtgg     1200

gctcagcctc atgcaccata gctgccttgg ggagctcaga tagggacact gtcgtggaac     1260

tctccgaatg gggtgtcccc tgtgtcacat gcattttgga tagaagacca gcttcatgtg     1320

gaacatgcgt tagggattgt tggcccgaaa ccggatccgt gcgttttccg ttccaccgct     1380

gcggaaccgg acctagactc actaaagatc tggaagccgt ccctttcgtt aataggacca     1440

ctcccttcac cattcgagga cctctgggta atcaaggccg gggaaacccc gtgcggagcc     1500

cacttggatt tggcagctac acaatgacga aaattcggga ctcattgcat cttgtgaaat     1560

gtccaacacc tgctattgag cccccgactg gcacctttgg attctttcct ggtgtgccac     1620

ccataaataa ttgcatgccg ctggggacgg aagtgagtga agcccttggc ggggcaggcc     1680

tgacgggtgg cttttatgaa ccactggtac gcagatgttc tgaactcatg ggacggcgga     1740

acccagtgtg ccctggctac gcatggctta gcagtggtcg gccagacggg ttcattcatg     1800

ttcaaggcca tttgcaggaa gtggacgccg gcaatttcat cccaccccct cgctggctgc     1860

tcctggactt tgtgtttgtg ctcctgtatc tgatgaagct ggcagaggcg aggttggtcc     1920

cactgatatt gctcctgctt tggtggtggg tcaatcagtt ggccgtgctc ggactgcccg     1980

cagtagacgc cgccgtggcc ggagaagttt tcgcaggccc cgccttgagt tggtgtctcg     2040

gattgcctac agtgagcatg atcctcggtc tcgcgaacct ggtgctttac ttccgctgga     2100

tggggccaca gaggttgatg tttctggttc tgtggaaatt ggctaggggt ttataagatc     2160

tgaattcacc ccaccagtg                                                  2179


<210>  496
<211>  710
<212>  PRT
<213>  Pegivirus Hepatitis G Virus


<400>  496

Met Ser Leu Leu Thr Asn Arg Phe Ile Arg Arg Val Asp Lys Asp Gln 
1               5                   10                  15      


Trp Gly Pro Gly Val Met Gly Lys Asp Pro Lys Pro Cys Pro Ser Arg 
            20                  25                  30          


Trp Ala Gly Lys Cys Met Gly Pro Pro Ser Ser Ala Ala Ala Cys Ser 
        35                  40                  45              


Arg Gly Ser Pro Arg Ile Leu Arg Val Arg Ala Gly Gly Ile Ser Leu 
    50                  55                  60                  


Phe Tyr Thr Ile Met Ala Val Leu Leu Leu Leu Leu Val Val Glu Ala 
65                  70                  75                  80  


Gly Ala Ile Leu Ala Pro Ala Thr His Ala Cys Arg Ala Asn Gly Gln 
                85                  90                  95      


Tyr Phe Leu Thr Asn Cys Cys Ala Pro Glu Asp Ile Gly Phe Cys Leu 
            100                 105                 110         


Glu Gly Gly Cys Leu Val Ala Leu Gly Cys Thr Val Cys Thr Asp Arg 
        115                 120                 125             


Cys Trp Pro Leu Tyr Gln Ala Gly Leu Ala Val Arg Pro Gly Lys Ser 
    130                 135                 140                 


Ala Ala Gln Leu Val Gly Glu Leu Gly Ser Leu Tyr Gly Pro Leu Ser 
145                 150                 155                 160 


Val Ser Ala Tyr Val Ala Gly Ile Leu Gly Leu Gly Glu Val Tyr Ser 
                165                 170                 175     


Gly Val Leu Thr Val Gly Val Ala Leu Arg Arg Arg Val Tyr Leu Met 
            180                 185                 190         


Pro Asn Leu Lys Cys Ala Val Glu Cys Asp Val Lys Trp Gly Ser Glu 
        195                 200                 205             


Phe Trp Arg Trp Thr Glu Gln Leu Ala Ser Asn Tyr Trp Ile Leu Glu 
    210                 215                 220                 


Tyr Leu Trp Lys Val Pro Phe Glu Phe Trp Arg Gly Val Met Ser Leu 
225                 230                 235                 240 


Thr Pro Leu Leu Val Trp Val Ala Ala Leu Leu Leu Leu Glu Gln Arg 
                245                 250                 255     


Ile Val Met Val Phe Leu Leu Val Thr Met Ala Gly Met Leu Gln Gly 
            260                 265                 270         


Ala Pro Ala Ser Val Leu Gly Ser Arg Pro Phe Asp Tyr Gly Leu Lys 
        275                 280                 285             


Trp Gln Ser Cys Ser Cys Arg Ala Asn Gly Ser Arg Ile Pro Thr Gly 
    290                 295                 300                 


Glu Arg Val Trp Asp Arg Gly Asn Val Thr Leu Leu Cys Asp Cys Pro 
305                 310                 315                 320 


Asn Gly Pro Trp Val Trp Val Pro Ala Phe Cys Gln Ala Val Gly Trp 
                325                 330                 335     


Gly Asp Pro Ile Thr His Trp Ser His Gly Gln Asn Gln Trp Pro Leu 
            340                 345                 350         


Ser Cys Pro Gln Tyr Val Tyr Gly Ser Val Ser Val Thr Cys Val Trp 
        355                 360                 365             


Gly Ser Val Ser Trp Phe Ala Ser Thr Gly Gly Arg Asp Ser Lys Ile 
    370                 375                 380                 


Asp Val Trp Ser Leu Val Pro Val Gly Ser Ala Ser Cys Thr Ile Ala 
385                 390                 395                 400 


Ala Leu Gly Ser Ser Asp Arg Asp Thr Val Val Glu Leu Ser Glu Trp 
                405                 410                 415     


Gly Val Pro Cys Val Thr Cys Ile Leu Asp Arg Arg Pro Ala Ser Cys 
            420                 425                 430         


Gly Thr Cys Val Arg Asp Cys Trp Pro Glu Thr Gly Ser Val Arg Phe 
        435                 440                 445             


Pro Phe His Arg Cys Gly Thr Gly Pro Arg Leu Thr Lys Asp Leu Glu 
    450                 455                 460                 


Ala Val Pro Phe Val Asn Arg Thr Thr Pro Phe Thr Ile Arg Gly Pro 
465                 470                 475                 480 


Leu Gly Asn Gln Gly Arg Gly Asn Pro Val Arg Ser Pro Leu Gly Phe 
                485                 490                 495     


Gly Ser Tyr Thr Met Thr Lys Ile Arg Asp Ser Leu His Leu Val Lys 
            500                 505                 510         


Cys Pro Thr Pro Ala Ile Glu Pro Pro Thr Gly Thr Phe Gly Phe Phe 
        515                 520                 525             


Pro Gly Val Pro Pro Ile Asn Asn Cys Met Pro Leu Gly Thr Glu Val 
    530                 535                 540                 


Ser Glu Ala Leu Gly Gly Ala Gly Leu Thr Gly Gly Phe Tyr Glu Pro 
545                 550                 555                 560 


Leu Val Arg Arg Cys Ser Glu Leu Met Gly Arg Arg Asn Pro Val Cys 
                565                 570                 575     


Pro Gly Tyr Ala Trp Leu Ser Ser Gly Arg Pro Asp Gly Phe Ile His 
            580                 585                 590         


Val Gln Gly His Leu Gln Glu Val Asp Ala Gly Asn Phe Ile Pro Pro 
        595                 600                 605             


Pro Arg Trp Leu Leu Leu Asp Phe Val Phe Val Leu Leu Tyr Leu Met 
    610                 615                 620                 


Lys Leu Ala Glu Ala Arg Leu Val Pro Leu Ile Leu Leu Leu Leu Trp 
625                 630                 635                 640 


Trp Trp Val Asn Gln Leu Ala Val Leu Gly Leu Pro Ala Val Asp Ala 
                645                 650                 655     


Ala Val Ala Gly Glu Val Phe Ala Gly Pro Ala Leu Ser Trp Cys Leu 
            660                 665                 670         


Gly Leu Pro Thr Val Ser Met Ile Leu Gly Leu Ala Asn Leu Val Leu 
        675                 680                 685             


Tyr Phe Arg Trp Met Gly Pro Gln Arg Leu Met Phe Leu Val Leu Trp 
    690                 695                 700                 


Lys Leu Ala Arg Gly Leu  
705                 710             


<210>  497
<211>  1666
<212>  DNA
<213>  Rubulavirus Mumps Virus F

<400>  497
gcaaagcacg tgagatcgcc accatgaaag tcttcctcgt gacctgtctt ggcttcgccg       60

tgttcagcag ttctgtgtgt gtgaatatca acatactgca gcagatcggc tatatcaaac      120

aacaagtgag gcagctctcc tattactctc agagtagcag ctcttacatt gtcgttaagc      180

tgctccccaa tattcaacca acagacaata gttgtgagtt taagtcagta acgcaatata      240

acaaaactct gtctaacctc ttgctcccta tagccgagaa cattaataac attgcatcac      300

catcatctgg aagcagaagg cataaacgct tcgctgggat tgccataggc attgcggccc      360

tcggcgtggc gacagctgcc caagtaaccg cggctgtcag cctcgttcaa gcccagacca      420

atgccagagc tatcgctgcg atgaagaata gcatccaggc cactaaccga gcagtcttcg      480

aagttaagga aggcacacag cggcttgcca tcgcggtaca agccattcaa gatcatatta      540

acacaattat gaatactcaa ctgaataaca tgtcatgtca gatccttgat aaccaactgg      600

ctacatctct gggcttgtac ctgaccgagc tgaccactgt ctttcagccc caactgatca      660

accctgccct gtcacctatc agcattcaag cactcaggtc acttcttggg tccatgactc      720

ccgctgtcgt gcaagctaca ctctcaacat ccatctctgc agccgaaatt ctgtccgctg      780

gcctcatgga aggccaaatt gtgagcgttc tcctcgatga gatgcagatg atagtcaaaa      840

ttaacattcc taccatagtg acgcaatcaa acgcactcgt aatcgacttt tacagtatct      900

ctagcttcat taataaccaa gaatctatca tccaattgcc agatcggatc cttgaaatcg      960

gaaatgaaca gtggagttat cctgcgaaga actgtaaatt gacgagacac cacatcttct     1020

gtcaatacaa tgaggccgaa agactcagcc tcgaatctaa actctgcttg gcaggcaata     1080

tcagcgcctg tgtattcagc cctatcgcag ggtcttatat gcggcgcttt gtagcactcg     1140

acggaacaat agtcgctaac tgccgatcat tgacctgtct gtgcaagagc cccagctacc     1200

ctatttatca acccgaccac catgctgtta ctacgattga cctcactgcg tgccagacct     1260

tgagcctcga tgggctcgat tttagtatag tctctctgag taatataaca tatgctgaaa     1320

acttgacaat cagcctgagt cagactatca acactcagcc cattgatatt tccacggaac     1380

ttagtaaagt aaacgccagc ctgcaaaacg cagttaaata tataaaggaa tccaatcatc     1440

aactccaaag cgtaaacgtt aatagcaaaa taggcgccat cattgtggct gcactggtcc     1500

tctcaatcct gtcaatcatt atcagccttt tgttctgttg ctgggcttac gtagccacta     1560

aagagatcag gcggatcaac ttcaaaacga accacattaa cacaatttca tctagcgtcg     1620

atgatctcat ccggtactta taagatctga attcacccca ccagtg                    1666


<210>  498
<211>  539
<212>  PRT
<213>  Rubulavirus Mumps Virus F

<400>  498

Met Lys Val Phe Leu Val Thr Cys Leu Gly Phe Ala Val Phe Ser Ser 
1               5                   10                  15      


Ser Val Cys Val Asn Ile Asn Ile Leu Gln Gln Ile Gly Tyr Ile Lys 
            20                  25                  30          


Gln Gln Val Arg Gln Leu Ser Tyr Tyr Ser Gln Ser Ser Ser Ser Tyr 
        35                  40                  45              


Ile Val Val Lys Leu Leu Pro Asn Ile Gln Pro Thr Asp Asn Ser Cys 
    50                  55                  60                  


Glu Phe Lys Ser Val Thr Gln Tyr Asn Lys Thr Leu Ser Asn Leu Leu 
65                  70                  75                  80  


Leu Pro Ile Ala Glu Asn Ile Asn Asn Ile Ala Ser Pro Ser Ser Gly 
                85                  90                  95      


Ser Arg Arg His Lys Arg Phe Ala Gly Ile Ala Ile Gly Ile Ala Ala 
            100                 105                 110         


Leu Gly Val Ala Thr Ala Ala Gln Val Thr Ala Ala Val Ser Leu Val 
        115                 120                 125             


Gln Ala Gln Thr Asn Ala Arg Ala Ile Ala Ala Met Lys Asn Ser Ile 
    130                 135                 140                 


Gln Ala Thr Asn Arg Ala Val Phe Glu Val Lys Glu Gly Thr Gln Arg 
145                 150                 155                 160 


Leu Ala Ile Ala Val Gln Ala Ile Gln Asp His Ile Asn Thr Ile Met 
                165                 170                 175     


Asn Thr Gln Leu Asn Asn Met Ser Cys Gln Ile Leu Asp Asn Gln Leu 
            180                 185                 190         


Ala Thr Ser Leu Gly Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gln 
        195                 200                 205             


Pro Gln Leu Ile Asn Pro Ala Leu Ser Pro Ile Ser Ile Gln Ala Leu 
    210                 215                 220                 


Arg Ser Leu Leu Gly Ser Met Thr Pro Ala Val Val Gln Ala Thr Leu 
225                 230                 235                 240 


Ser Thr Ser Ile Ser Ala Ala Glu Ile Leu Ser Ala Gly Leu Met Glu 
                245                 250                 255     


Gly Gln Ile Val Ser Val Leu Leu Asp Glu Met Gln Met Ile Val Lys 
            260                 265                 270         


Ile Asn Ile Pro Thr Ile Val Thr Gln Ser Asn Ala Leu Val Ile Asp 
        275                 280                 285             


Phe Tyr Ser Ile Ser Ser Phe Ile Asn Asn Gln Glu Ser Ile Ile Gln 
    290                 295                 300                 


Leu Pro Asp Arg Ile Leu Glu Ile Gly Asn Glu Gln Trp Ser Tyr Pro 
305                 310                 315                 320 


Ala Lys Asn Cys Lys Leu Thr Arg His His Ile Phe Cys Gln Tyr Asn 
                325                 330                 335     


Glu Ala Glu Arg Leu Ser Leu Glu Ser Lys Leu Cys Leu Ala Gly Asn 
            340                 345                 350         


Ile Ser Ala Cys Val Phe Ser Pro Ile Ala Gly Ser Tyr Met Arg Arg 
        355                 360                 365             


Phe Val Ala Leu Asp Gly Thr Ile Val Ala Asn Cys Arg Ser Leu Thr 
    370                 375                 380                 


Cys Leu Cys Lys Ser Pro Ser Tyr Pro Ile Tyr Gln Pro Asp His His 
385                 390                 395                 400 


Ala Val Thr Thr Ile Asp Leu Thr Ala Cys Gln Thr Leu Ser Leu Asp 
                405                 410                 415     


Gly Leu Asp Phe Ser Ile Val Ser Leu Ser Asn Ile Thr Tyr Ala Glu 
            420                 425                 430         


Asn Leu Thr Ile Ser Leu Ser Gln Thr Ile Asn Thr Gln Pro Ile Asp 
        435                 440                 445             


Ile Ser Thr Glu Leu Ser Lys Val Asn Ala Ser Leu Gln Asn Ala Val 
    450                 455                 460                 


Lys Tyr Ile Lys Glu Ser Asn His Gln Leu Gln Ser Val Asn Val Asn 
465                 470                 475                 480 


Ser Lys Ile Gly Ala Ile Ile Val Ala Ala Leu Val Leu Ser Ile Leu 
                485                 490                 495     


Ser Ile Ile Ile Ser Leu Leu Phe Cys Cys Trp Ala Tyr Val Ala Thr 
            500                 505                 510         


Lys Glu Ile Arg Arg Ile Asn Phe Lys Thr Asn His Ile Asn Thr Ile 
        515                 520                 525             


Ser Ser Ser Val Asp Asp Leu Ile Arg Tyr Leu 
    530                 535                 


<210>  499
<211>  1798
<212>  DNA
<213>  Rubulavirus Mumps Virus HN

<400>  499
gcaaagcacg tgagatcgcc accatggaac ctagtaagct tttcaccatg tccgataatg       60

ctacattcgc accaggcccc gtcattaacg cagccgacaa gaaaacattc cgtacatgtt      120

tccgcattct ggtcctgtca gtccaggcag tcactcttat tctggtaatt gttactctgg      180

gcgaactcgt tcgcatgatt aacgaccagg gactgtctaa ccagctctcc tctattgccg      240

ataagatcag agagtccgcc accatgatcg catcagcagt cggagtgatg aatcaagtga      300

ttcatggggt gacagtttca ctgccactcc aaatagaagg aaatcaaaat cagcttctct      360

caactcttgc cacgatttgc acaggaaaga agcaggtttc taactgttct actaacatac      420

cattggtgaa tgatctgcgg tttattaatg ggatcaataa gttcatcatt gaagactatg      480

ctacgcatga cttcagcatt ggccacccgc tgaatatgcc tagttttatc ccaacagcca      540

caagccccaa tggttgcacc cggattccgt cctttagctt ggggaaaacc cattggtgct      600

atacccacaa tgttattaac gctaattgca aagatcatac atcttccaat caatacatta      660

gcatgggcat ccttgtacaa acggcctcag gctatcccat gtttaaaact ctgaaaatac      720

aatatctgag cgatggcctg aacaggaaga gttgctctat cgcaaccgtg cctgatgggt      780

gcgcaatgta ctgttatgtg agtacccaac ttgaaaccga tgactatgca ggctcttctc      840

cccctaccca gaaactgaca ctgctgttct ataacgatac tgttacggag cgtaccataa      900

gccccactgg acttgaaggt aattgggcta cccttgtgcc tggagtagga tccggtatct      960

actttgagaa taagctcata ttccctgcgt atggcggggt gctgcccaac agttctctcg     1020

gcgtcaagag tgcacgcgag ttcttcagac cagtgaaccc ctataatccc tgctcagggc     1080

cccaacaaga cttggatcag cgcgcactta gatcctattt tccttcctat tttagtaatc     1140

gtcgagtcca gagcgctttc ctcgtgtgtg cttggaatca gattttggta acaaactgtg     1200

aactggtcgt cccatccaat aatcaaaccc ttatgggagc agaagggcgg gtcctgctta     1260

ttaacaaccg actgctctac taccaaagaa gcacaagttg gtggccatac gaacttctct     1320

atgaaatttc cttcacattc accaacagtg gtcagagctc agtgaatatg agttggatac     1380

ccatatatag ctttacacga cctggatcag gcaactgtag cggggaaaat gtttgtccta     1440

cagcatgtgt aagtggcgtt tatctggatc cgtggccgct taccccatac tcccatcaat     1500

ccggtattaa ccgaaatttc tatttcactg gcgcactctt gaacagtagt acgacaagag     1560

taaaccccac cctgtacgtt tcagctttga acaatcttaa ggtgctggct ccatatggaa     1620

atcagggtct gtttgcttcc tacactacta caacatgttt ccaagatacc ggagatgcct     1680

ctgtatattg tgtgtatatc atggaactgg cgtcaaacat cgtcggcgaa tttcaaatat     1740

tgcccgtcct gactcggctg acaataacct tataagatct gaattcaccc caccagtg       1798


<210>  500
<211>  583
<212>  PRT
<213>  Rubulavirus Mumps Virus HN

<400>  500

Met Glu Pro Ser Lys Leu Phe Thr Met Ser Asp Asn Ala Thr Phe Ala 
1               5                   10                  15      


Pro Gly Pro Val Ile Asn Ala Ala Asp Lys Lys Thr Phe Arg Thr Cys 
            20                  25                  30          


Phe Arg Ile Leu Val Leu Ser Val Gln Ala Val Thr Leu Ile Leu Val 
        35                  40                  45              


Ile Val Thr Leu Gly Glu Leu Val Arg Met Ile Asn Asp Gln Gly Leu 
    50                  55                  60                  


Ser Asn Gln Leu Ser Ser Ile Ala Asp Lys Ile Arg Glu Ser Ala Thr 
65                  70                  75                  80  


Met Ile Ala Ser Ala Val Gly Val Met Asn Gln Val Ile His Gly Val 
                85                  90                  95      


Thr Val Ser Leu Pro Leu Gln Ile Glu Gly Asn Gln Asn Gln Leu Leu 
            100                 105                 110         


Ser Thr Leu Ala Thr Ile Cys Thr Gly Lys Lys Gln Val Ser Asn Cys 
        115                 120                 125             


Ser Thr Asn Ile Pro Leu Val Asn Asp Leu Arg Phe Ile Asn Gly Ile 
    130                 135                 140                 


Asn Lys Phe Ile Ile Glu Asp Tyr Ala Thr His Asp Phe Ser Ile Gly 
145                 150                 155                 160 


His Pro Leu Asn Met Pro Ser Phe Ile Pro Thr Ala Thr Ser Pro Asn 
                165                 170                 175     


Gly Cys Thr Arg Ile Pro Ser Phe Ser Leu Gly Lys Thr His Trp Cys 
            180                 185                 190         


Tyr Thr His Asn Val Ile Asn Ala Asn Cys Lys Asp His Thr Ser Ser 
        195                 200                 205             


Asn Gln Tyr Ile Ser Met Gly Ile Leu Val Gln Thr Ala Ser Gly Tyr 
    210                 215                 220                 


Pro Met Phe Lys Thr Leu Lys Ile Gln Tyr Leu Ser Asp Gly Leu Asn 
225                 230                 235                 240 


Arg Lys Ser Cys Ser Ile Ala Thr Val Pro Asp Gly Cys Ala Met Tyr 
                245                 250                 255     


Cys Tyr Val Ser Thr Gln Leu Glu Thr Asp Asp Tyr Ala Gly Ser Ser 
            260                 265                 270         


Pro Pro Thr Gln Lys Leu Thr Leu Leu Phe Tyr Asn Asp Thr Val Thr 
        275                 280                 285             


Glu Arg Thr Ile Ser Pro Thr Gly Leu Glu Gly Asn Trp Ala Thr Leu 
    290                 295                 300                 


Val Pro Gly Val Gly Ser Gly Ile Tyr Phe Glu Asn Lys Leu Ile Phe 
305                 310                 315                 320 


Pro Ala Tyr Gly Gly Val Leu Pro Asn Ser Ser Leu Gly Val Lys Ser 
                325                 330                 335     


Ala Arg Glu Phe Phe Arg Pro Val Asn Pro Tyr Asn Pro Cys Ser Gly 
            340                 345                 350         


Pro Gln Gln Asp Leu Asp Gln Arg Ala Leu Arg Ser Tyr Phe Pro Ser 
        355                 360                 365             


Tyr Phe Ser Asn Arg Arg Val Gln Ser Ala Phe Leu Val Cys Ala Trp 
    370                 375                 380                 


Asn Gln Ile Leu Val Thr Asn Cys Glu Leu Val Val Pro Ser Asn Asn 
385                 390                 395                 400 


Gln Thr Leu Met Gly Ala Glu Gly Arg Val Leu Leu Ile Asn Asn Arg 
                405                 410                 415     


Leu Leu Tyr Tyr Gln Arg Ser Thr Ser Trp Trp Pro Tyr Glu Leu Leu 
            420                 425                 430         


Tyr Glu Ile Ser Phe Thr Phe Thr Asn Ser Gly Gln Ser Ser Val Asn 
        435                 440                 445             


Met Ser Trp Ile Pro Ile Tyr Ser Phe Thr Arg Pro Gly Ser Gly Asn 
    450                 455                 460                 


Cys Ser Gly Glu Asn Val Cys Pro Thr Ala Cys Val Ser Gly Val Tyr 
465                 470                 475                 480 


Leu Asp Pro Trp Pro Leu Thr Pro Tyr Ser His Gln Ser Gly Ile Asn 
                485                 490                 495     


Arg Asn Phe Tyr Phe Thr Gly Ala Leu Leu Asn Ser Ser Thr Thr Arg 
            500                 505                 510         


Val Asn Pro Thr Leu Tyr Val Ser Ala Leu Asn Asn Leu Lys Val Leu 
        515                 520                 525             


Ala Pro Tyr Gly Asn Gln Gly Leu Phe Ala Ser Tyr Thr Thr Thr Thr 
    530                 535                 540                 


Cys Phe Gln Asp Thr Gly Asp Ala Ser Val Tyr Cys Val Tyr Ile Met 
545                 550                 555                 560 


Glu Leu Ala Ser Asn Ile Val Gly Glu Phe Gln Ile Leu Pro Val Leu 
                565                 570                 575     


Thr Arg Leu Thr Ile Thr Leu 
            580             


<210>  501
<211>  1747
<212>  DNA
<213>  Respirovirus Sendai Virus F

<400>  501
gcaaagcacg tgagatcgcc accatgactg catacattca aagaagccaa tgcattagca       60

caagtctcct tgtggtgctg acgaccctcg tttcctgtca gatcccgcgt gatcgacttt      120

ccaatatcgg ggttattgtc gacgagggca agtccttgaa aatcgcaggt tcccacgagt      180

ctaggtacat cgtgctgtca ctggttcccg gcgtcgactt tgagaatggt tgcggtacag      240

cccaagtaat tcagtacaag agcctgctca acaggcttct gatccctctc cgagatgcct      300

tggatctgca agaagctctg attactgtga cgaacgacac gactcaaaat gccggggctc      360

cacagtctcg cttcttcggc gcagtgatcg gcacgatcgc tctgggcgtt gccacttccg      420

ctcagatcac cgctggtatt gcccttgctg aagctcggga agccaaacgt gatattgcgc      480

tgataaagga gagcatgaca aagactcata agtcaatcga actgcttcag aacgccgtgg      540

gagagcaaat tcttgctctc aaaaccctgc aggacttcgt gaatgatgag attaaaccag      600

ccatcagtga actgggttgc gagactgctg ctctgcgtct gggaattaaa ctgacccaac      660

attactccga gctcctcact gctttcggct ctaactttgg aacgattgga gagaaaagcc      720

tgacccttca ggctctctct tctctctact ccgccaacat cacagagatt atgacgacga      780

tcaaaacggg gcaatccaac atttatgatg tcatttatac tgagcagatc aaaggtaccg      840

tgatcgatgt tgacctggaa aggtacatgg tgacactctc agtcaaaatc cccatcctca      900

gtgaggtgcc aggcgtattg attcataaag caagcagcat tagctataac atagatgggg      960

aagagtggta cgttaccgtc cccagtcata tactgtctag agccagtttc ctcggtggtg     1020

cagatataac cgactgtgtg gagagccggc tgacctatat ttgtccgcgc gatcccgcac     1080

aattgattcc agacagccag caaaagtgca tcctcgggga caccacacga tgtcctgtta     1140

cgaaggtagt cgactcactg atccccaagt tcgccttcgt caacggtggc gtagttgcca     1200

attgcattgc cagcacttgt acatgtggca caggacgcag acctattagc caagatcgtt     1260

caaagggcgt ggttttcctc acacacgata attgcggact gataggggtg aacggtgttg     1320

aactttacgc taaccgcaga ggacacgatg caacatgggg cgtacagaat ttgacagtcg     1380

ggcctgcaat tgcaatacgt cctatcgaca tctctctcaa cctggcggac gctaccaatt     1440

ttctgcaaga ctccaaggct gaacttgaga aagcgaggaa gattctgtcc gaagtcggcc     1500

gatggtataa ctctcgggaa actgtcatta ccatcattgt cgtgatggtt gtcattttgg     1560

tggtgatcat tgtgataatt attgtcctct ataggctgag gagatctatg ctgatgggta     1620

acccggatga cagaatccca cgcgacacgt acacccttga gccgaaaatt cggcatatgt     1680

atacgaatgg tggatttgat gcaatggcgg aaaagcgctt ataagatctg aattcacccc     1740

accagtg                                                               1747


<210>  502
<211>  566
<212>  PRT
<213>  Respirovirus Sendai Virus F

<400>  502

Met Thr Ala Tyr Ile Gln Arg Ser Gln Cys Ile Ser Thr Ser Leu Leu 
1               5                   10                  15      


Val Val Leu Thr Thr Leu Val Ser Cys Gln Ile Pro Arg Asp Arg Leu 
            20                  25                  30          


Ser Asn Ile Gly Val Ile Val Asp Glu Gly Lys Ser Leu Lys Ile Ala 
        35                  40                  45              


Gly Ser His Glu Ser Arg Tyr Ile Val Leu Ser Leu Val Pro Gly Val 
    50                  55                  60                  


Asp Phe Glu Asn Gly Cys Gly Thr Ala Gln Val Ile Gln Tyr Lys Ser 
65                  70                  75                  80  


Leu Leu Asn Arg Leu Leu Ile Pro Leu Arg Asp Ala Leu Asp Leu Gln 
                85                  90                  95      


Glu Ala Leu Ile Thr Val Thr Asn Asp Thr Thr Gln Asn Ala Gly Ala 
            100                 105                 110         


Pro Gln Ser Arg Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly 
        115                 120                 125             


Val Ala Thr Ser Ala Gln Ile Thr Ala Gly Ile Ala Leu Ala Glu Ala 
    130                 135                 140                 


Arg Glu Ala Lys Arg Asp Ile Ala Leu Ile Lys Glu Ser Met Thr Lys 
145                 150                 155                 160 


Thr His Lys Ser Ile Glu Leu Leu Gln Asn Ala Val Gly Glu Gln Ile 
                165                 170                 175     


Leu Ala Leu Lys Thr Leu Gln Asp Phe Val Asn Asp Glu Ile Lys Pro 
            180                 185                 190         


Ala Ile Ser Glu Leu Gly Cys Glu Thr Ala Ala Leu Arg Leu Gly Ile 
        195                 200                 205             


Lys Leu Thr Gln His Tyr Ser Glu Leu Leu Thr Ala Phe Gly Ser Asn 
    210                 215                 220                 


Phe Gly Thr Ile Gly Glu Lys Ser Leu Thr Leu Gln Ala Leu Ser Ser 
225                 230                 235                 240 


Leu Tyr Ser Ala Asn Ile Thr Glu Ile Met Thr Thr Ile Lys Thr Gly 
                245                 250                 255     


Gln Ser Asn Ile Tyr Asp Val Ile Tyr Thr Glu Gln Ile Lys Gly Thr 
            260                 265                 270         


Val Ile Asp Val Asp Leu Glu Arg Tyr Met Val Thr Leu Ser Val Lys 
        275                 280                 285             


Ile Pro Ile Leu Ser Glu Val Pro Gly Val Leu Ile His Lys Ala Ser 
    290                 295                 300                 


Ser Ile Ser Tyr Asn Ile Asp Gly Glu Glu Trp Tyr Val Thr Val Pro 
305                 310                 315                 320 


Ser His Ile Leu Ser Arg Ala Ser Phe Leu Gly Gly Ala Asp Ile Thr 
                325                 330                 335     


Asp Cys Val Glu Ser Arg Leu Thr Tyr Ile Cys Pro Arg Asp Pro Ala 
            340                 345                 350         


Gln Leu Ile Pro Asp Ser Gln Gln Lys Cys Ile Leu Gly Asp Thr Thr 
        355                 360                 365             


Arg Cys Pro Val Thr Lys Val Val Asp Ser Leu Ile Pro Lys Phe Ala 
    370                 375                 380                 


Phe Val Asn Gly Gly Val Val Ala Asn Cys Ile Ala Ser Thr Cys Thr 
385                 390                 395                 400 


Cys Gly Thr Gly Arg Arg Pro Ile Ser Gln Asp Arg Ser Lys Gly Val 
                405                 410                 415     


Val Phe Leu Thr His Asp Asn Cys Gly Leu Ile Gly Val Asn Gly Val 
            420                 425                 430         


Glu Leu Tyr Ala Asn Arg Arg Gly His Asp Ala Thr Trp Gly Val Gln 
        435                 440                 445             


Asn Leu Thr Val Gly Pro Ala Ile Ala Ile Arg Pro Ile Asp Ile Ser 
    450                 455                 460                 


Leu Asn Leu Ala Asp Ala Thr Asn Phe Leu Gln Asp Ser Lys Ala Glu 
465                 470                 475                 480 


Leu Glu Lys Ala Arg Lys Ile Leu Ser Glu Val Gly Arg Trp Tyr Asn 
                485                 490                 495     


Ser Arg Glu Thr Val Ile Thr Ile Ile Val Val Met Val Val Ile Leu 
            500                 505                 510         


Val Val Ile Ile Val Ile Ile Ile Val Leu Tyr Arg Leu Arg Arg Ser 
        515                 520                 525             


Met Leu Met Gly Asn Pro Asp Asp Arg Ile Pro Arg Asp Thr Tyr Thr 
    530                 535                 540                 


Leu Glu Pro Lys Ile Arg His Met Tyr Thr Asn Gly Gly Phe Asp Ala 
545                 550                 555                 560 


Met Ala Glu Lys Arg Leu 
                565     


<210>  503
<211>  1777
<212>  DNA
<213>  Respirovirus Sendai Virus HN

<400>  503
gcaaagcacg tgagatcgcc accatggatg gcgaccgagg caaacgcgac tcttattgga       60

gcacttcccc tagtgggtcc accactaagc cggctagcgg atgggagaga tcaagtaagg      120

ccgatacgtg gctcttgatc ttgagcttca cccaatgggc tttgagtatt gctactgtta      180

ttatttgcat catcatctca gctcggcaag gatactctat gaaagagtac agcatgacgg      240

tggaagcatt gaatatgtct tctcgggaag tgaaggaatc actcacatct ttgattaggc      300

aggaagtcat agcccgggct gtgaatatcc aatccagcgt ccaaacaggg atcccggtgc      360

tcctgaacaa gaactcccga gacgtcatcc aaatgatcga taaatcttgt tcacgccaag      420

aacttaccca acattgtgaa agcactattg ccgtccatca cgcagacggc attgcacccc      480

tggagccgca ctcattctgg cgttgcccgg ttggtgaacc ctatctgtca tctgaccccg      540

agatcagtct gctccctgga ccttcactcc tctccggttc caccacgata agcgggtgtg      600

tcaggttgcc atccctctcc atcggggaag cgatttatgc gtatagcagc aacttgatta      660

cgcaaggctg tgctgacatc ggtaagtcct accaggtgct tcagcttggt tatatcagcc      720

ttaattctga tatgtttccg gacctcaatc ctgtggtctc acatacatat gacatcaatg      780

acaacagaaa atcctgtagc gtagtcgcaa cagggacgag agggtatcaa ctctgttcta      840

tgcctacagt cgacgagaga actgattata gctcagacgg aatcgaagat ctcgtcctgg      900

acgttctcga tttgaaaggt cgcacaaaat cacaccgcta cagaaattcc gaggtggacc      960

tcgatcatcc tttctccgcg ttgtatccta gtgtgggcaa cggcattgct actgaaggct     1020

ccttgatttt cctcgggtac ggcggcctca ccacaccctt gcaaggtgat acaaaatgcc     1080

gtacgcaagg ctgccaacag gtttctcaag atacttgcaa cgaggctctg aagataactt     1140

ggcttggcgg gaaacaagtg gtttctgtga tcattcaggt caatgattac ctgagtgaaa     1200

ggcctaaaat tagggtcacc accattccca ttacccaaaa ctatctcggt gctgagggca     1260

ggctgttgaa gctcggtgat cgggtctata tatatactcg gagcagtggt tggcactctc     1320

aactgcaaat aggggtcttg gacgtgtccc acccgttgac cattaattgg acacctcatg     1380

aggcgctgtc acggccaggg aataaagaat gcaactggta caataagtgc cccaaagaat     1440

gtatctccgg ggtctacaca gacgcttacc ccctgtctcc agatgctgct aatgtcgcta     1500

cagttactct gtacgccaat acttctagag tgaaccccac tattatgtat tccaacacga     1560

ccaatataat caatatgctt cggataaaag atgtacaact tgaagccgct tacactacta     1620

cgtcctgtat aacacacttt gggaaaggct attgctttca catcattgag attaatcaaa     1680

agagtctgaa tactctccaa cccatgctgt ttaaaacatc aatcccaaaa ttgtgtaaag     1740

cggaaagttt ataagatctg aattcacccc accagtg                              1777


<210>  504
<211>  576
<212>  PRT
<213>  Respirovirus Sendai Virus HN

<400>  504

Met Asp Gly Asp Arg Gly Lys Arg Asp Ser Tyr Trp Ser Thr Ser Pro 
1               5                   10                  15      


Ser Gly Ser Thr Thr Lys Pro Ala Ser Gly Trp Glu Arg Ser Ser Lys 
            20                  25                  30          


Ala Asp Thr Trp Leu Leu Ile Leu Ser Phe Thr Gln Trp Ala Leu Ser 
        35                  40                  45              


Ile Ala Thr Val Ile Ile Cys Ile Ile Ile Ser Ala Arg Gln Gly Tyr 
    50                  55                  60                  


Ser Met Lys Glu Tyr Ser Met Thr Val Glu Ala Leu Asn Met Ser Ser 
65                  70                  75                  80  


Arg Glu Val Lys Glu Ser Leu Thr Ser Leu Ile Arg Gln Glu Val Ile 
                85                  90                  95      


Ala Arg Ala Val Asn Ile Gln Ser Ser Val Gln Thr Gly Ile Pro Val 
            100                 105                 110         


Leu Leu Asn Lys Asn Ser Arg Asp Val Ile Gln Met Ile Asp Lys Ser 
        115                 120                 125             


Cys Ser Arg Gln Glu Leu Thr Gln His Cys Glu Ser Thr Ile Ala Val 
    130                 135                 140                 


His His Ala Asp Gly Ile Ala Pro Leu Glu Pro His Ser Phe Trp Arg 
145                 150                 155                 160 


Cys Pro Val Gly Glu Pro Tyr Leu Ser Ser Asp Pro Glu Ile Ser Leu 
                165                 170                 175     


Leu Pro Gly Pro Ser Leu Leu Ser Gly Ser Thr Thr Ile Ser Gly Cys 
            180                 185                 190         


Val Arg Leu Pro Ser Leu Ser Ile Gly Glu Ala Ile Tyr Ala Tyr Ser 
        195                 200                 205             


Ser Asn Leu Ile Thr Gln Gly Cys Ala Asp Ile Gly Lys Ser Tyr Gln 
    210                 215                 220                 


Val Leu Gln Leu Gly Tyr Ile Ser Leu Asn Ser Asp Met Phe Pro Asp 
225                 230                 235                 240 


Leu Asn Pro Val Val Ser His Thr Tyr Asp Ile Asn Asp Asn Arg Lys 
                245                 250                 255     


Ser Cys Ser Val Val Ala Thr Gly Thr Arg Gly Tyr Gln Leu Cys Ser 
            260                 265                 270         


Met Pro Thr Val Asp Glu Arg Thr Asp Tyr Ser Ser Asp Gly Ile Glu 
        275                 280                 285             


Asp Leu Val Leu Asp Val Leu Asp Leu Lys Gly Arg Thr Lys Ser His 
    290                 295                 300                 


Arg Tyr Arg Asn Ser Glu Val Asp Leu Asp His Pro Phe Ser Ala Leu 
305                 310                 315                 320 


Tyr Pro Ser Val Gly Asn Gly Ile Ala Thr Glu Gly Ser Leu Ile Phe 
                325                 330                 335     


Leu Gly Tyr Gly Gly Leu Thr Thr Pro Leu Gln Gly Asp Thr Lys Cys 
            340                 345                 350         


Arg Thr Gln Gly Cys Gln Gln Val Ser Gln Asp Thr Cys Asn Glu Ala 
        355                 360                 365             


Leu Lys Ile Thr Trp Leu Gly Gly Lys Gln Val Val Ser Val Ile Ile 
    370                 375                 380                 


Gln Val Asn Asp Tyr Leu Ser Glu Arg Pro Lys Ile Arg Val Thr Thr 
385                 390                 395                 400 


Ile Pro Ile Thr Gln Asn Tyr Leu Gly Ala Glu Gly Arg Leu Leu Lys 
                405                 410                 415     


Leu Gly Asp Arg Val Tyr Ile Tyr Thr Arg Ser Ser Gly Trp His Ser 
            420                 425                 430         


Gln Leu Gln Ile Gly Val Leu Asp Val Ser His Pro Leu Thr Ile Asn 
        435                 440                 445             


Trp Thr Pro His Glu Ala Leu Ser Arg Pro Gly Asn Lys Glu Cys Asn 
    450                 455                 460                 


Trp Tyr Asn Lys Cys Pro Lys Glu Cys Ile Ser Gly Val Tyr Thr Asp 
465                 470                 475                 480 


Ala Tyr Pro Leu Ser Pro Asp Ala Ala Asn Val Ala Thr Val Thr Leu 
                485                 490                 495     


Tyr Ala Asn Thr Ser Arg Val Asn Pro Thr Ile Met Tyr Ser Asn Thr 
            500                 505                 510         


Thr Asn Ile Ile Asn Met Leu Arg Ile Lys Asp Val Gln Leu Glu Ala 
        515                 520                 525             


Ala Tyr Thr Thr Thr Ser Cys Ile Thr His Phe Gly Lys Gly Tyr Cys 
    530                 535                 540                 


Phe His Ile Ile Glu Ile Asn Gln Lys Ser Leu Asn Thr Leu Gln Pro 
545                 550                 555                 560 


Met Leu Phe Lys Thr Ser Ile Pro Lys Leu Cys Lys Ala Glu Ser Leu 
                565                 570                 575     


<210>  505
<211>  1590
<212>  DNA
<213>  Alphabaculovirus Autographa californica nuclear polyhedrosis virus

<400>  505
atgctgctcg tgaaccagag ccaccagggc ttcaacaagg agcatacatc caaaatggtg       60

tccgccatcg tgctgtacgt gctgctggcc gccgctgccc acagcgcttt tgccgccgag      120

cattgtaatg ctcagatgaa aaccggccct tacaagatca agaacctgga catcacccct      180

cctaaggaga cactgcaaaa agacgtggaa atcaccatcg tggaaaccga ctacaatgag      240

aacgtgatca tcggatataa gggctactac caggcctacg cctacaacgg cggaagcctg      300

gatcctaaca ccagagtgga agagaccatg aagaccctga acgtgggaaa ggaagatctg      360

ctgatgtgga gcatccggca acagtgtgaa gtgggcgaag agctgattga tagatggggc      420

tcagattctg acgattgctt cagagacaac gagggcagag gccagtgggt gaagggcaag      480

gagctggtca agcggcagaa caacaaccac ttcgcccatc acacatgcaa caaaagctgg      540

cggtgcggca tctccacctc taagatgtat tctagactgg aatgtcagga cgacaccgac      600

gagtgccagg tgtacatcct ggacgctgaa ggaaacccta tcaacgtgac agttgacacc      660

gtgctgcacc gggacggcgt gtctatgatc ctgaagcaga agagcacatt caccaccaga      720

cagatcaagg ccgcatgcct gcttatcaaa gacgacaaga acaaccccga gagcgtgacc      780

agagaacact gcctgatcga caacgacatc tacgacctga gcaagaatac ttggaactgt      840

aaattcaaca ggtgcatcaa gcggaaggtg gagcacagag tgaagaagcg tccaccaacc      900

tggcgccaca acgtcagagc caagtacaca gagggcgaca cagccacaaa gggagatctg      960

atgcacatcc aggaggaact gatgtacgag aatgacctgc ttaaaatgaa catcgagctg     1020

atgcacgccc acatcaacaa gctgaacaac atgctgcacg acctgatcgt tagcgtggcc     1080

aaggtggacg agagactgat cggcaatctg atgaacaaca gcgtgtccag caccttcctg     1140

tctgatgaca cctttctgct catgccttgc accaaccccc ccgcccacac cagcaactgc     1200

tacaacaaca gcatctacaa ggaaggcaga tgggtcgcta ataccgatag cagtcagtgc     1260

atcgacttca gcaattacaa ggagctggcc atcgacgatg atgtggagtt ctggattcct     1320

acaattggca acacaaccta ccacgatagc tggaaggacg ccagcggatg gtcttttatc     1380

gcccagcaga aaagcaatct gatcaccacc atggaaaata ccaagttcgg cggcgtgggt     1440

acatctctga gcgacatcac aagcatggcc gagggcgagc tggccgccaa gctgaccagc     1500

ttcatgttcg gccacgtcgt gaacttcgtg atcatcctga tcgtgattct gttcctgtac     1560

tgcatgatca gaaaccggaa cagacaatac                                      1590


<210>  506
<211>  530
<212>  PRT
<213>  Alphabaculovirus Autographa californica nuclear polyhedrosis virus

<400>  506

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Glu His Cys Asn Ala Gln Met Lys Thr 
        35                  40                  45              


Gly Pro Tyr Lys Ile Lys Asn Leu Asp Ile Thr Pro Pro Lys Glu Thr 
    50                  55                  60                  


Leu Gln Lys Asp Val Glu Ile Thr Ile Val Glu Thr Asp Tyr Asn Glu 
65                  70                  75                  80  


Asn Val Ile Ile Gly Tyr Lys Gly Tyr Tyr Gln Ala Tyr Ala Tyr Asn 
                85                  90                  95      


Gly Gly Ser Leu Asp Pro Asn Thr Arg Val Glu Glu Thr Met Lys Thr 
            100                 105                 110         


Leu Asn Val Gly Lys Glu Asp Leu Leu Met Trp Ser Ile Arg Gln Gln 
        115                 120                 125             


Cys Glu Val Gly Glu Glu Leu Ile Asp Arg Trp Gly Ser Asp Ser Asp 
    130                 135                 140                 


Asp Cys Phe Arg Asp Asn Glu Gly Arg Gly Gln Trp Val Lys Gly Lys 
145                 150                 155                 160 


Glu Leu Val Lys Arg Gln Asn Asn Asn His Phe Ala His His Thr Cys 
                165                 170                 175     


Asn Lys Ser Trp Arg Cys Gly Ile Ser Thr Ser Lys Met Tyr Ser Arg 
            180                 185                 190         


Leu Glu Cys Gln Asp Asp Thr Asp Glu Cys Gln Val Tyr Ile Leu Asp 
        195                 200                 205             


Ala Glu Gly Asn Pro Ile Asn Val Thr Val Asp Thr Val Leu His Arg 
    210                 215                 220                 


Asp Gly Val Ser Met Ile Leu Lys Gln Lys Ser Thr Phe Thr Thr Arg 
225                 230                 235                 240 


Gln Ile Lys Ala Ala Cys Leu Leu Ile Lys Asp Asp Lys Asn Asn Pro 
                245                 250                 255     


Glu Ser Val Thr Arg Glu His Cys Leu Ile Asp Asn Asp Ile Tyr Asp 
            260                 265                 270         


Leu Ser Lys Asn Thr Trp Asn Cys Lys Phe Asn Arg Cys Ile Lys Arg 
        275                 280                 285             


Lys Val Glu His Arg Val Lys Lys Arg Pro Pro Thr Trp Arg His Asn 
    290                 295                 300                 


Val Arg Ala Lys Tyr Thr Glu Gly Asp Thr Ala Thr Lys Gly Asp Leu 
305                 310                 315                 320 


Met His Ile Gln Glu Glu Leu Met Tyr Glu Asn Asp Leu Leu Lys Met 
                325                 330                 335     


Asn Ile Glu Leu Met His Ala His Ile Asn Lys Leu Asn Asn Met Leu 
            340                 345                 350         


His Asp Leu Ile Val Ser Val Ala Lys Val Asp Glu Arg Leu Ile Gly 
        355                 360                 365             


Asn Leu Met Asn Asn Ser Val Ser Ser Thr Phe Leu Ser Asp Asp Thr 
    370                 375                 380                 


Phe Leu Leu Met Pro Cys Thr Asn Pro Pro Ala His Thr Ser Asn Cys 
385                 390                 395                 400 


Tyr Asn Asn Ser Ile Tyr Lys Glu Gly Arg Trp Val Ala Asn Thr Asp 
                405                 410                 415     


Ser Ser Gln Cys Ile Asp Phe Ser Asn Tyr Lys Glu Leu Ala Ile Asp 
            420                 425                 430         


Asp Asp Val Glu Phe Trp Ile Pro Thr Ile Gly Asn Thr Thr Tyr His 
        435                 440                 445             


Asp Ser Trp Lys Asp Ala Ser Gly Trp Ser Phe Ile Ala Gln Gln Lys 
    450                 455                 460                 


Ser Asn Leu Ile Thr Thr Met Glu Asn Thr Lys Phe Gly Gly Val Gly 
465                 470                 475                 480 


Thr Ser Leu Ser Asp Ile Thr Ser Met Ala Glu Gly Glu Leu Ala Ala 
                485                 490                 495     


Lys Leu Thr Ser Phe Met Phe Gly His Val Val Asn Phe Val Ile Ile 
            500                 505                 510         


Leu Ile Val Ile Leu Phe Leu Tyr Cys Met Ile Arg Asn Arg Asn Arg 
        515                 520                 525             


Gln Tyr 
    530 


<210>  507
<211>  2955
<212>  DNA
<213>  Alphavirus Ross River Virus

<400>  507
atgtctgccg cgctgatgat gtgtatcctt gccaacacct ctttcccctg ctcatcacct       60

ccctgctacc cctgctgcta cgaaaaacag ccagaacaga cactgcggat gctggaagac      120

aatgtgaata gaccagggta ctatgagcta ctggaagcgt ccatgacatg cagaaacaga      180

tcacgccacc gccgtagtgt aacagagcac ttcaatgtgt ataaggctac tagaccgtac      240

ttagcgtatt gcgctgactg tggggacggg tacttctgct atagcccagt tgctatcgag      300

aagatccgag atgaggcgcc tgacggcatg ctcaagatcc aagtctccgc ccaaataggt      360

ctggacaagg caggtaccca cgcccacacg aagatccgat atatggctgg tcatgatgtt      420

caggaatcta agagagactc cttgagggtg tacacgtccg cagcgtgctc tatacatggg      480

acgatgggac acttcatcgt cgcacattgt ccgccaggcg actacctcaa ggtttcgttc      540

gaggacgcag attcacacgt gaaggcatgt aaggtccaat acaagcacga cccattgccg      600

gtgggtagag agaagttcgt ggttagaccc cactttggcg tagagctgcc atgcacctca      660

taccagctga caacagctcc caccgacgag gagatcgaca tgcacacacc gccagatata      720

ccggatcgca ccctgctatc acagacggcg ggcaacgtca aaataacagc aggcggcagg      780

actatcaggt acaattgtac ctgtggccgt gacaacgtag gcactaccag tactgacaag      840

accatcaaca catgcaagat tgaccaatgc catgctgccg ttaccagcca tgacaaatgg      900

caatttacct ctccatttgt tcccagggct gatcagacag ctaggagggg caaagtgcat      960

gttccattcc ctttgactaa cgtcacctgc cgagtgccgt tggctcgagc gccggatgtc     1020

acctatggta agaaggaggt gaccctgaga ttacacccag atcatccgac gctcttctcc     1080

tataggagtt taggagccga accgcacccg tacgaggagt gggttgacaa gttctctgag     1140

cgcatcatcc cagtgacgga agaagggatt gagtaccagt ggggcaacaa cccgccggtc     1200

cgcctatggg cgcaactgac gaccgagggc aaaccccatg gctggccaca tgaaatcatt     1260

cagtactatt atggactata ccccgccgcc accattgccg cagtatccgg ggcgagtctg     1320

atggccctcc taactctagc ggccacatgc tgcatgctgg ccaccgcgag gagaaagtgc     1380

ctaacaccat acgccttgac gccaggagcg gtggtaccgt tgacactggg gctgctttgc     1440

tgcgcaccga gggcgaacgc agcatcattc gctgagacta tggcatatct gtgggacgag     1500

aacaaaaccc tcttttggat ggaattcgcc gccccagccg cagcgcttgc tttgctggca     1560

tgctgtatca aaagcctgat ctgctgttgt aagccatttt cttttttagt gttactgagc     1620

ctgggagcct ccgcaaaagc ttacgagcac acagccacaa ttccgaatgt ggtggggttc     1680

ccgtataagg ctcacattga aaggaatggc ttctcgccca tgactctgca gcttgaagtg     1740

gtggagacaa gctgggaacc cacacttaac ctggagtaca ttacctgcga atacaagacg     1800

gtggtccctt cgccattcat caaatgttgc ggaacatcag aatgctcatc caaggagcag     1860

ccagactacc aatgcaaggt gtacacgggt gtatacccat tcatgtgggg tggagcctac     1920

tgtttctgcg actccgagaa cacgcagctc agcgaggcct atgtcgacag gtcagacgtt     1980

tgcaaacatg atcacgcatc ggcctacaag gcacacacgg cctctctaaa agcaacaatc     2040

aggatcagtt atggcaccat caaccagacc accgaggcct tcgttaatgg tgaacacgcg     2100

gtcaacgtgg gcggaagcaa gttcatcttt ggaccgatct caacagcttg gtcaccgttc     2160

gacaataaaa ttgtcgtgta taaagatgat gtctacaacc aggacttccc accctacgga     2220

tcaggccagc cgggtagatt cggagacatt cagagcagga cagtggagag caaagacttg     2280

tatgccaaca cggccctaaa actctcaaga ccatcacccg gggttgtgca tgtgccatac     2340

acgccgacac catccggatt taaatattgg ctgaaggaga aaggatcttc attgaataca     2400

aaggcccctt ttggctgcaa gataaagacc aatccagtca gagccatgga ttgtgcagtt     2460

ggcagtatac ctgtgtcgat ggacatacct gacagtgcat tcacacgagt ggtagatgcc     2520

ccggctgtaa cagacctgag ctgccaggta gtggtctgta cacactcctc cgatttcgga     2580

ggagttgcca cattgtctta caaaacggac aaacccggca agtgcgctgt ccactcacat     2640

tccaacgtcg caacgttgca agaggcgacg gtggatgtca aggaggatgg caaggtcaca     2700

gtgcactttt ccacggcgtc cgcctccccg gccttcaaag tgtccgtctg tgacgcaaaa     2760

acaacgtgca cggcggcgtg cgagcctcca aaagaccaca tcgtccctta tggggcgagc     2820

cataacaacc aggtctttcc ggacatgtca ggaactgcga tgacgtgggt gcagaggctg     2880

gccagtgggt taggtgggct ggctctcatc gcggtggttg tgctggtctt ggtaacctgc     2940

ataacaatgc gtcgg                                                      2955


<210>  508
<211>  985
<212>  PRT
<213>  Alphavirus Ross River Virus

<400>  508

Met Ser Ala Ala Leu Met Met Cys Ile Leu Ala Asn Thr Ser Phe Pro 
1               5                   10                  15      


Cys Ser Ser Pro Pro Cys Tyr Pro Cys Cys Tyr Glu Lys Gln Pro Glu 
            20                  25                  30          


Gln Thr Leu Arg Met Leu Glu Asp Asn Val Asn Arg Pro Gly Tyr Tyr 
        35                  40                  45              


Glu Leu Leu Glu Ala Ser Met Thr Cys Arg Asn Arg Ser Arg His Arg 
    50                  55                  60                  


Arg Ser Val Thr Glu His Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr 
65                  70                  75                  80  


Leu Ala Tyr Cys Ala Asp Cys Gly Asp Gly Tyr Phe Cys Tyr Ser Pro 
                85                  90                  95      


Val Ala Ile Glu Lys Ile Arg Asp Glu Ala Pro Asp Gly Met Leu Lys 
            100                 105                 110         


Ile Gln Val Ser Ala Gln Ile Gly Leu Asp Lys Ala Gly Thr His Ala 
        115                 120                 125             


His Thr Lys Ile Arg Tyr Met Ala Gly His Asp Val Gln Glu Ser Lys 
    130                 135                 140                 


Arg Asp Ser Leu Arg Val Tyr Thr Ser Ala Ala Cys Ser Ile His Gly 
145                 150                 155                 160 


Thr Met Gly His Phe Ile Val Ala His Cys Pro Pro Gly Asp Tyr Leu 
                165                 170                 175     


Lys Val Ser Phe Glu Asp Ala Asp Ser His Val Lys Ala Cys Lys Val 
            180                 185                 190         


Gln Tyr Lys His Asp Pro Leu Pro Val Gly Arg Glu Lys Phe Val Val 
        195                 200                 205             


Arg Pro His Phe Gly Val Glu Leu Pro Cys Thr Ser Tyr Gln Leu Thr 
    210                 215                 220                 


Thr Ala Pro Thr Asp Glu Glu Ile Asp Met His Thr Pro Pro Asp Ile 
225                 230                 235                 240 


Pro Asp Arg Thr Leu Leu Ser Gln Thr Ala Gly Asn Val Lys Ile Thr 
                245                 250                 255     


Ala Gly Gly Arg Thr Ile Arg Tyr Asn Cys Thr Cys Gly Arg Asp Asn 
            260                 265                 270         


Val Gly Thr Thr Ser Thr Asp Lys Thr Ile Asn Thr Cys Lys Ile Asp 
        275                 280                 285             


Gln Cys His Ala Ala Val Thr Ser His Asp Lys Trp Gln Phe Thr Ser 
    290                 295                 300                 


Pro Phe Val Pro Arg Ala Asp Gln Thr Ala Arg Arg Gly Lys Val His 
305                 310                 315                 320 


Val Pro Phe Pro Leu Thr Asn Val Thr Cys Arg Val Pro Leu Ala Arg 
                325                 330                 335     


Ala Pro Asp Val Thr Tyr Gly Lys Lys Glu Val Thr Leu Arg Leu His 
            340                 345                 350         


Pro Asp His Pro Thr Leu Phe Ser Tyr Arg Ser Leu Gly Ala Glu Pro 
        355                 360                 365             


His Pro Tyr Glu Glu Trp Val Asp Lys Phe Ser Glu Arg Ile Ile Pro 
    370                 375                 380                 


Val Thr Glu Glu Gly Ile Glu Tyr Gln Trp Gly Asn Asn Pro Pro Val 
385                 390                 395                 400 


Arg Leu Trp Ala Gln Leu Thr Thr Glu Gly Lys Pro His Gly Trp Pro 
                405                 410                 415     


His Glu Ile Ile Gln Tyr Tyr Tyr Gly Leu Tyr Pro Ala Ala Thr Ile 
            420                 425                 430         


Ala Ala Val Ser Gly Ala Ser Leu Met Ala Leu Leu Thr Leu Ala Ala 
        435                 440                 445             


Thr Cys Cys Met Leu Ala Thr Ala Arg Arg Lys Cys Leu Thr Pro Tyr 
    450                 455                 460                 


Ala Leu Thr Pro Gly Ala Val Val Pro Leu Thr Leu Gly Leu Leu Cys 
465                 470                 475                 480 


Cys Ala Pro Arg Ala Asn Ala Ala Ser Phe Ala Glu Thr Met Ala Tyr 
                485                 490                 495     


Leu Trp Asp Glu Asn Lys Thr Leu Phe Trp Met Glu Phe Ala Ala Pro 
            500                 505                 510         


Ala Ala Ala Leu Ala Leu Leu Ala Cys Cys Ile Lys Ser Leu Ile Cys 
        515                 520                 525             


Cys Cys Lys Pro Phe Ser Phe Leu Val Leu Leu Ser Leu Gly Ala Ser 
    530                 535                 540                 


Ala Lys Ala Tyr Glu His Thr Ala Thr Ile Pro Asn Val Val Gly Phe 
545                 550                 555                 560 


Pro Tyr Lys Ala His Ile Glu Arg Asn Gly Phe Ser Pro Met Thr Leu 
                565                 570                 575     


Gln Leu Glu Val Val Glu Thr Ser Trp Glu Pro Thr Leu Asn Leu Glu 
            580                 585                 590         


Tyr Ile Thr Cys Glu Tyr Lys Thr Val Val Pro Ser Pro Phe Ile Lys 
        595                 600                 605             


Cys Cys Gly Thr Ser Glu Cys Ser Ser Lys Glu Gln Pro Asp Tyr Gln 
    610                 615                 620                 


Cys Lys Val Tyr Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr 
625                 630                 635                 640 


Cys Phe Cys Asp Ser Glu Asn Thr Gln Leu Ser Glu Ala Tyr Val Asp 
                645                 650                 655     


Arg Ser Asp Val Cys Lys His Asp His Ala Ser Ala Tyr Lys Ala His 
            660                 665                 670         


Thr Ala Ser Leu Lys Ala Thr Ile Arg Ile Ser Tyr Gly Thr Ile Asn 
        675                 680                 685             


Gln Thr Thr Glu Ala Phe Val Asn Gly Glu His Ala Val Asn Val Gly 
    690                 695                 700                 


Gly Ser Lys Phe Ile Phe Gly Pro Ile Ser Thr Ala Trp Ser Pro Phe 
705                 710                 715                 720 


Asp Asn Lys Ile Val Val Tyr Lys Asp Asp Val Tyr Asn Gln Asp Phe 
                725                 730                 735     


Pro Pro Tyr Gly Ser Gly Gln Pro Gly Arg Phe Gly Asp Ile Gln Ser 
            740                 745                 750         


Arg Thr Val Glu Ser Lys Asp Leu Tyr Ala Asn Thr Ala Leu Lys Leu 
        755                 760                 765             


Ser Arg Pro Ser Pro Gly Val Val His Val Pro Tyr Thr Pro Thr Pro 
    770                 775                 780                 


Ser Gly Phe Lys Tyr Trp Leu Lys Glu Lys Gly Ser Ser Leu Asn Thr 
785                 790                 795                 800 


Lys Ala Pro Phe Gly Cys Lys Ile Lys Thr Asn Pro Val Arg Ala Met 
                805                 810                 815     


Asp Cys Ala Val Gly Ser Ile Pro Val Ser Met Asp Ile Pro Asp Ser 
            820                 825                 830         


Ala Phe Thr Arg Val Val Asp Ala Pro Ala Val Thr Asp Leu Ser Cys 
        835                 840                 845             


Gln Val Val Val Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Thr 
    850                 855                 860                 


Leu Ser Tyr Lys Thr Asp Lys Pro Gly Lys Cys Ala Val His Ser His 
865                 870                 875                 880 


Ser Asn Val Ala Thr Leu Gln Glu Ala Thr Val Asp Val Lys Glu Asp 
                885                 890                 895     


Gly Lys Val Thr Val His Phe Ser Thr Ala Ser Ala Ser Pro Ala Phe 
            900                 905                 910         


Lys Val Ser Val Cys Asp Ala Lys Thr Thr Cys Thr Ala Ala Cys Glu 
        915                 920                 925             


Pro Pro Lys Asp His Ile Val Pro Tyr Gly Ala Ser His Asn Asn Gln 
    930                 935                 940                 


Val Phe Pro Asp Met Ser Gly Thr Ala Met Thr Trp Val Gln Arg Leu 
945                 950                 955                 960 


Ala Ser Gly Leu Gly Gly Leu Ala Leu Ile Ala Val Val Val Leu Val 
                965                 970                 975     


Leu Val Thr Cys Ile Thr Met Arg Arg 
            980                 985 


<210>  509
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  codon optimized rabies virus glycoprotein

<400>  509
atggtgcccc aggccctgct cttcgtgcct ctgctcgtct ttccactgtg cttcggcaaa       60

tttcccatct acactattcc tgacaagctg ggaccctgga gtcctatcga tattcaccat      120

ctgtcatgcc ctaacaatct cgtggtcgag gatgaagggt gtaccaacct gtcaggtttc      180

agctacatgg agctgaaagt ggggtatatc ctcgctatta aggtcaacgg cttcacatgc      240

actggagtgg tcaccgaggc agaaacctac acaaattttg tgggctatgt caccacaact      300

ttcaagagga aacactttag accaacaccc gacgcctgtc gcgccgctta caactggaag      360

atggctggcg atccacgata tgaggaatct ctgcacaatc cttacccaga ctatagatgg      420

ctgcggacag tgaagaccac aaaagagagc ctggtcatca ttagcccatc cgtcgcagac      480

ctggatccct acgatagatc cctgcactct cgggtgtttc cctctggcaa gtgcagtgga      540

gtggccgtca gctccactta ctgtagcacc aaccatgatt atactatctg gatgccagag      600

aatccccggc tgggaatgtc ctgcgacatt ttcacatcta gtcgcgggaa gcgagccagt      660

aaagggtcag agacttgtgg ttttgtggac gaaaggggcc tgtataagag cctcaaagga      720

gcttgcaagc tgaaactctg tggcgtgctg ggactcagac tgatggatgg aacctgggtc      780

tcaatgcaga caagcaacga gactaagtgg tgcccccctg acaaactcgt gaatctgcac      840

gacttcaggt ccgatgagat cgaacatctg gtggtcgagg aactcgtgcg aaaaagggag      900

gaatgtctcg atgctctgga gtctatcatg actaccaagt ctgtgagttt taggagactc      960

agtcacctga gaaagctcgt ccctggcttc ggaaaagcat acaccatctt taacaagaca     1020

ctgatggaag cagacgccca ttataaaagc gtggagacct ggaatgaaat cctgccatcc     1080

aagggatgcc tccgagtcgg aggacgctgt caccctcatg tgaacggcgt cttctttaat     1140

ggaatcattc tggggcctga cggtaacgtg ctgatcccag agatgcagtc aagcctgctc     1200

cagcagcaca tggagctgct cgaatcctct gtgattcctc tggtccatcc actcgcagat     1260

ccctctacag tgttcaagga cggggatgag gccgaagact ttgtggaggt ccacctgcca     1320

gatgtgcata accaggtgtc tggggtcgac ctcggtctgc ccaattgggg gaagtacgtg     1380

ctgctcagcg ccggtgcact gactgctctc atgctgatca ttttcctgat gacctgctgt     1440

cgacgagtga accggtccga gcctactcag cacaatctgc gagggaccgg tagagaagtg     1500

tccgtcacac cacagtctgg caaaatcatt agttcatggg agagccataa gtccgggggt     1560

gaaacacgcc tgtga                                                      1575


<210>  510
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies Virus

<400>  510

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Ser Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Lys Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Glu 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  511
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain Nishigahara RCEH

<400>  511
acgtgagatc gccaccatgg tgcctcaggc tctgctgctg gtccctatcc tgggattcag       60

ctcctgcttc ggcaagttcc ccatctacac catccctgac accctgggcc cttggtcccc      120

aatcgacatc caccacctga gctgccccaa caacctggtc gtggaggatg aaggctgtac      180

caatctgagc ggcttcagct acatggaact gaaggtggga tatatcagcg ccatcaaggt      240

gaatggcttc acctgcaccg gcgtggtgac cgaggccgag acatacacaa acttcgtggg      300

ctacgtgacc acaaccttca agcggaagca cttcagacct acaccagacg cctgtagagc      360

cgcctacaac tggaagatgg ccggagatcc cagatacgag gaatctctgc acagccccta      420

ccccgactac cactggctga gaaccgtgaa gacaaccaag gaatccctgg tgattatcag      480

ccctagcgtg gccgacctgg acccttacga caacagccta catagcagag tgtttccttc      540

tggcaagtgt agcggcatca ccgtgtccag cgtgtactgc agcaccaacc acgactacac      600

cgtttggatg cctgagagcc tgcggctggg gaccagctgc gacattttta ctaatagcag      660

aggaaaacgg gcttctaaag gatctaaaac ctgtggcttt gtggacgaga gaggcctgta      720

caaatctctg aaaggcgcct gcaagctgaa gctgtgcggc gttctgggcc tcagactgat      780

ggacggcacc tgggttgcta tgcaaacaag caacgagaca aagtggtgtc ctcctgacca      840

gttggtgaac ctgcacgatc tgcggtctga tgagatcgag cacctggtga tcgaggaact      900

ggtcaagaag cgcgaggaat gcctggatgc cctggaaagc atcattacaa ccaaatcagt      960

gtcttttaga cggctgtcct acctgcggaa gctggtgccc ggcttcggca aggcctatac     1020

aatctttaac aagaccctga tggaagcaga agcccactac aagagcgtgc ggacctggaa     1080

cgaaatcatc cctagcaagg gctgcctgag ggtggggggc agatgccacc ctcacgtgaa     1140

cggcgtgttc ttcaacggca tcatcctggg ccctgacggc cacgtgctga tccctgagat     1200

gcagagctct ctgctgcagc agcacatcga gctgctcgag agctctgtga tcccactgat     1260

gcaccccctg gccgatcctt tcaccgtttt caaggacggc gacgaaacag aagatttcat     1320

cgaggtgcat ctgcccgacg tgcacgagca ggtgtctgga gtggacctgg gcctgcctaa     1380

ttggggcgaa tacgtgctgc tgagcgctgg cacccttatc gccctcatgc tgatcatctt     1440

cctgatgacc tgctgcagaa aggtggatag accagagagc acccagcgga gcctgagagg     1500

caccggaaga aacgtgtccg tgacaagcca gagcggcaag ttcatcccca gctgggagtc     1560

ttataagagc ggaggcgaga caggcctgtg aattcacccc accagtg                   1607


<210>  512
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain Nishigahara RCEH

<400>  512

Met Val Pro Gln Ala Leu Leu Leu Val Pro Ile Leu Gly Phe Ser Ser 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Thr Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Ser Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Asn Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Val Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Val Trp Met Pro Glu Ser Leu Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Leu Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Ile Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Ile Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser Tyr Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Phe Thr Val Phe Lys Asp Gly Asp Glu Thr Glu 
            420                 425                 430         


Asp Phe Ile Glu Val His Leu Pro Asp Val His Glu Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Glu Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Thr Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Lys Val Asp Arg Pro Glu Ser Thr Gln Arg Ser Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Thr Ser Gln Ser Gly Lys Phe Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Gly Leu 
        515                 520                 


<210>  513
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain India

<400>  513
acgtgagatc gccaccatgg ttcctcaggt gctgctcttc gtgcctctgc tggtcttttc       60

catgtgcttc ggcaaattcc ccatctacac catcccagac aagctgggcc cttggagccc      120

tatcgacatc caccacctga gctgccctaa caacctcgtg gtggaagatg agggctgtac      180

aaacctgtct ggcttttctt atatggagct gaaagtggga tacatcagcg ccatcaaggt      240

gaacggcttc acctgcaccg gcgtggtgac agaggccgag acatacacca acttcgtggg      300

ctacgtgaca accaccttca agagaaagca cttccggcct acccctgacg cctgcagagc      360

cgcttacaac tggaagatgg ccggcgatcc tagatacgag gaaagcctgc ataatcctta      420

tcctgactac cactggctga gaacagtgaa aaccaccaag gaatccctgg tgatcatcag      480

cccctctgta gccgatctgg acccctacga caagagcctg cacagcagag tgttccctag      540

cggaaaatgc agcggtatca ccatctctag cacatactgc agcaccaacc acgactacac      600

gatctggatg cccgagaacc ccagactggg cacctcctgc gacattttta caaatagccg      660

gggcaagcgg gccagcaagg gcggcaagac atgcggcttc gtggacgaga gaggcctgta      720

caaaagcctg aagggcgcct gtaaactgaa gctgtgcgga gtgcttggcc tgcgactgat      780

ggacggcaca tgggtggcca tgcaaacaag cgatgaaacc aagtggtgcc cacctgacca      840

gctggtgaac ctgcatgatt tcagaagcga cgaaatcgag cacctggtgg tcgaggaact      900

ggtgaagaag cgggaggagt gcctggatgc cctggaaagc atcatggcta caaagagcgt      960

gtcatttcgc agactgagcc acctgcggaa gctggtgcct ggcttcggca aagcctacac     1020

catcttcaac aagaccctga tggaagctga tgcccactac aagtctgtgc ggacctggaa     1080

cgagatcatt cccagcaagg gatgtctgag agtgggcgga aggtgccacc cccacgtgaa     1140

tggcgtgttc ttcaacggca tcatcctggg ccccgacggc cacgtgctga tcccagagat     1200

gcagagcagc ctgctgcagc agcacatgga actgctggaa tctagcgtga tccctctgat     1260

gcaccccctg gccgaccctt ctaccgtgtt taaggacgga gatgaggctg aggacttcgt     1320

ggaagtgcat ctccctgacg tgcacaagca gatctctggc gttgatctgg gactgcctag     1380

ctggggcaag tacgtgctgg tgtccgcagg cgtgctggtg gtcctgatgc tgaccatttt     1440

catcatgacc tgttgtggca gagtgcacag acccaagtcc acccagcacg gcctgggcgg     1500

aaccggcaga aaggtgtccg tcaccagcca gtctggcaaa gtaatcagca gctgggagag     1560

ctacaagagt ggaggcgaga caagactgtg aattcacccc accagtg                   1607


<210>  514
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain India

<400>  514

Met Val Pro Gln Val Leu Leu Phe Val Pro Leu Leu Val Phe Ser Met 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Ile Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Gly Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Ala Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Ser Trp Gly Lys Tyr Val Leu Val Ser Ala 
    450                 455                 460                 


Gly Val Leu Val Val Leu Met Leu Thr Ile Phe Ile Met Thr Cys Cys 
465                 470                 475                 480 


Gly Arg Val His Arg Pro Lys Ser Thr Gln His Gly Leu Gly Gly Thr 
                485                 490                 495     


Gly Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  515
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain CVS-11

<400>  515
acgtgagatc gccaccatgg tgcctcaggt gctgctgttc gtgccactgc tgggatttag       60

cctgtgcttc ggaaaattcc caatctacac catccccgat aagctggggc cttggagccc      120

tatcgacatc caccacctgt catgccccaa caacctggtg gtggaagatg agggctgcac      180

caacctgagc gagttcagct acatggaact gaaagtgggc tacatcagcg ccatcaaggt      240

gaatggcttc acctgcaccg gagtagtgac cgaggccgaa acctacacaa acttcgtggg      300

ctacgtcaca accacattca agagaaagca cttccggccc acccctgatg cttgtagagc      360

cgcttacaac tggaagatgg ccggcgaccc tcggtacgag gaaagcctgc acaaccctta      420

tcctgactac cactggctga gaacagtgag aaccaccaaa gagtctctca tcattatcag      480

ccctagcgtg acagacctgg atccttacga caagtccctc cattctcggg tgtttccagg      540

cggaaagtgc agcggcatca ccgtgagctc tacctactgc agcaccaacc acgactatac      600

aatctggatg cccgagaacc ccagacccag aacaccgtgc gacatcttca ccaacagcag      660

agggaaaaga gccagcaaag gcaacaaaac ctgtggcttc gtggacgaaa gaggcctgta      720

taagtccctg aagggagcct gcagactgaa gctgtgcggc gtgctgggcc ttagactgat      780

ggacggcacc tgggtggcca tgcagacaag cgacgagaca aagtggtgtc ctcctgacca      840

gctggtcaac ctgcatgatt tccgcagtga cgagatcgag cacctggtcg tggaagagct      900

ggttaagaag cgggaagagt gtctggacgc cctggaaagc atcatgacca ccaagagcgt      960

gtccttccgg agactgagcc acctgagaaa gctggtgccc ggctttggca aggcctacac     1020

catctttaac aagaccctga tggaagccga cgcccactac aagagcgtgc ggacctggaa     1080

cgagatcatt cccagcaagg gctgtctgaa agtgggaggc cggtgccacc ctcacgtgaa     1140

tggcgtcttt ttcaacggca tcatcctggg ccctgacggc cacgtgctga ttcctgagat     1200

gcaatctagc ctcctgcagc agcacatgga actgctgaag tctagcgtga tccctctgat     1260

gcaccccctg gccgatcctt ctaccgtgtt caaggaaggc gatgaggccg aggacttcgt     1320

cgaggtgcac cttcctgacg tgtacaagca gatctccggc gtggatctgg gactgcctaa     1380

ttggggcaag tacgtgctga tgacagccgg agctatgatc ggcctggtgc tgatcttctc     1440

cctgatgacc tggtgcagac gggctaatag acctgagtcc aaacagagaa gcttcggcgg     1500

cacaggcagg aacgtgtctg tgacatctca gagcggcaag gtgatcccaa gctgggagag     1560

ttacaagagc ggcggagaaa tcagactgtg aattcacccc accagtg                   1607


<210>  516
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain CVS-11

<400>  516

Met Val Pro Gln Val Leu Leu Phe Val Pro Leu Leu Gly Phe Ser Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Glu Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Arg Thr Thr Lys Glu Ser Leu Ile Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Arg Thr Pro Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Asn Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Arg Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Lys Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Glu Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Tyr Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Met Thr Ala 
    450                 455                 460                 


Gly Ala Met Ile Gly Leu Val Leu Ile Phe Ser Leu Met Thr Trp Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Pro Glu Ser Lys Gln Arg Ser Phe Gly Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Ile Arg Leu 
        515                 520                 


<210>  517
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain ERA

<400>  517
acgtgagatc gccaccatgg tgcctcaggc cctgttgttt gtgccactcc tggtgttccc       60

actgtgcttc ggcaaattcc ctatctacac catcctggat aagctgggcc catggagccc      120

catcgacatc caccacctgt cttgtcctaa caacctggtg gtcgaggatg agggctgcac      180

caatctgagc ggcttcagct acatggagct gaaggtgggc tacatcctgg ccatcaagat      240

gaacggcttc acctgtacag gagtggtgac cgaggccgag acttatacaa acttcgtggg      300

ctacgtgaca acaaccttca agcggaagca cttcagacct acacctgatg cctgtagagc      360

cgcttacaac tggaaaatgg ccggcgatcc aagatacgag gaatctctcc ataatcctta      420

tcctgattac agatggctgc gcaccgtgaa gaccaccaaa gagtccctgg tcatcatctc      480

ccctagcgtg gccgacctgg acccttacga ccggagcctg cacagcagag tgttcccttc      540

cggcaagtgc agcggcgtgg ccgtgagctc cacctactgc tctacaaacc acgactacac      600

catctggatg cctgaaaacc ccagactggg aatgagctgc gacatcttca caaacagccg      660

gggcaagcgg gcctctaagg gcagcgagac ctgcggattt gtggacgaaa gaggcctgta      720

caagagcctc aaaggcgcct gcaagctgaa gctgtgtggc gtgctgggtc tcagactgat      780

ggacggcaca tgggtggcca tgcagaccag caacgagacc aaatggtgcc cccccgacca      840

gctggtgaac ctgcacgact tccggagcga cgagatcgag cacctggtgg tggaagaact      900

ggttagaaag cgggaagagt gcctggacgc tctggaaagc atcatgacca ccaagagcgt      960

ttcttttcgg cggctgagcc acctgagaaa actggtgccc ggcttcggaa aggcctacac     1020

catcttcaac aagacactga tggaagctga tgcccactac aagtctgtga ggacatggaa     1080

cgagattctg cctagcaagg gatgtctgag agtgggcgga agatgccacc cccacgtgaa     1140

tggcgtgttt ttcaacggca tcatcctggg ccctgatggc aacgtgctga tccctgagat     1200

gcaaagcagc ctgctgcagc agcatatgga actgctggaa agctctgtta tccccctggt     1260

gcatcctctg gctgacccca gtaccgtgtt caaggacggc gacgaggctg aggacttcgt     1320

ggaagtgcac ctgcccgatg ttcacaacca ggtgtccggc gtcgacctgg gcctgcctaa     1380

ttggggcaag tacgtgctgc tgagcgccgg cgccctgacc gccctgatgc tgatcatctt     1440

cctgatgaca tgctgcagaa gggttaacag aagcgagcct acccagcaca acctgcgcgg     1500

gaccggcaga gaggtgtctg tgacacctca gtctggaaag atcattagca gctgggagtc     1560

ccacaagagc ggaggagaaa ccagactgtg aattcacccc accagtg                   1607


<210>  518
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain ERA

<400>  518

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Leu Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  519
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain SAD B19

<400>  519
acgtgagatc gccaccatgg tgccccaggc ccttctgttc gtgcctctgc tggtctttcc       60

tctgtgtttc ggcaagttcc ccatctacac aatccctgat aagctgggcc cttggtcccc      120

tatcgacatc caccacctgt cttgccctaa caacctggtc gtggaagatg agggctgtac      180

aaatctgagc ggcttcagct acatggaact caaagtgggc tacatcctgg ctatcaaggt      240

gaacggattt acctgtaccg gcgtggtgac cgaggctgaa acctacacca acttcgtggg      300

atatgtgaca accacattca agcggaagca cttccggcct accccagacg cctgcagagc      360

cgcttataac tggaagatgg ccggagatcc tagatacgag gaaagcctgc acaaccctta      420

ccccgattac agatggctgc gcaccgtgaa gaccacaaag gaaagcctgg tgatcatttc      480

tccttctgtc gccgatctgg acccttacga cagaagcctg cacagcagag tgtttcctag      540

cggcaaatgc agcggcgtgg ccgtgagcag tacatactgc agcaccaacc acgactacac      600

catttggatg ccagagaacc ccagactggg catgagctgc gacatcttca ccaacagccg      660

gggaaaacgg gcctctaagg gcagcgagac atgtggcttc gttgacgaga gaggcctgta      720

caagtcactg aagggcgcct gcaagctgaa gctgtgcggc gtcctgggcc taagactgat      780

ggacggcacc tgggtgtcca tgcaaacaag caacgagacc aagtggtgcc cccccgacaa      840

gctggtgaat ctccatgatt tcaggtctga tgagatcgag cacctggtgg tcgaggaact      900

ggtgcggaaa agagaagagt gcctggatgc tcttgagagc atcatgacaa ccaagagcgt      960

gtccttcaga cggctgagcc acctgagaaa gctggttcct ggcttcggca aagcctacac     1020

catcttcaac aagaccctga tggaggccga cgcccactac aagtccgtgc ggacctggaa     1080

cgagatcctg ccaagcaagg gatgtctgcg ggtgggcggc agatgccacc cccacgtgaa     1140

cggcgttttc ttcaacggca tcatcctggg tcctgacgga aatgtgctga tccccgagat     1200

gcagagcagc ctgctgcagc agcacatgga actgctggaa tcttctgtga tcccactggt     1260

gcatcctctg gccgacccta gcacagtgtt taaggacggc gacgaggccg aggacttcgt     1320

ggaagtgcac ctgcccgacg tgcacaacca ggtgagcggc gtggacctgg gtctgcctaa     1380

ttggggcaaa tacgtactgc tgagcgccgg cgctctgacc gccctgatgc tgatcatctt     1440

tctgatgacc tgctgccgga gagtgaacag aagcgagccc acccagcaca atctgagggg     1500

cacaggaaga gaggtgtccg tgacccctca gagcggcaag atcatcagct cttgggaaag     1560

ccacaagagc ggcggagaaa ccagactgtg aattcacccc accagtg                   1607


<210>  520
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain SAD B19

<400>  520

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Arg Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ser Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Lys Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  521
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain Vnukovo-32

<400>  521
acgtgagatc gccaccatgg tgccccaggc cctgcttttc gtgccactgc tggtgttccc       60

tctgtgcttc ggcaagttcc ccatctacac aatccctgat aagctgggcc cttggtcccc      120

tatcgacatc caccacctga gctgtcctaa caacctggtg gtggaggacg agggctgcac      180

aaatctgagc ggcttcagct acatggagct gaaggtgggc tacatcctgg ctatcaagat      240

gaacggattc acctgcaccg gagtggtgac cgaggctgaa aactacacca atttcgtggg      300

ctacgtcacc acgacattca aaagaaagca cctgcggccc acacctgacg cctgtagggc      360

cgcttacaac tggaaaatgg ccggcgaccc tagatacgag gaatccctgc acaaccccta      420

tcctgattac agctggctga ggaccgtgaa gaccaccaag gaaagcctcg tcatcatcag      480

ccctagcgtg gccgatctgg atccttacga cagaagcctc cattctcggg tgtttccaag      540

cggcaagtgc agcggcgttg ccgtgtctag cacctactgc agcaccaacc acgattacac      600

catctggatg cctgagaacc ctagactggg caaaagctgc gacatcttca caaatagcag      660

aggaaaacgg gcctctaagg gcagcgaaac ctgtggcttt gtggacgaga gaggcctgta      720

caagagcctg aaaggcgcct gcaagctgaa actctgcggc gtgctgggcc tgagactgat      780

ggacggcacc tgggtggcca tgcaaaccag caacgagaca aagtggtgcc cacctgacca      840

gctggtgaac ctgcacgact tccggagcga cgagatcgag cacctggtag tggaagagct      900

ggtgcggaag cgggaagagt gcctggacgc tctggaaagc atcatgacca ccaagtccgt      960

gtcttttaga cggctgtccc acctgcggaa gctggtcccc ggcttcggca aggcctatac     1020

catctttaac aagaccctga tggaagccga cgcccactac aagtccgtca gaacctggaa     1080

cgagatcctg cctagcaagg gatgtctgag agtgggcgga agatgccacc cccacgtgaa     1140

cggcgtgttc ttcaacggca tcatcctggg ccccgatggc aacgtgctga tccccgagat     1200

gcagagcagc cttctccagc agcacatgga actgctggaa agctctgtta ttccactggt     1260

gcaccctctg gccgaccctt ctacagtgtt caaggacggc gatgaggccg aggacttcgt     1320

ggaagtgcat ctgcctgatg tgcacaacca ggtgtccgga gtggacctgg gcctgcccaa     1380

ctggggaaaa tacgtgctgc tgagcgccgg agccctgacc gccctgatgc tgatcatttt     1440

cctgatgacc tgttgcagaa gagtgaatag aagcgagcct acacagcaca atctgcgcgg     1500

aacaggcaga gaagtcagcg tgacacctca gacctggaag atcatctcta gttgggagag     1560

tcacaagtct ggcggcgaga caagactgtg aattcacccc accagtg                   1607


<210>  522
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain Vnukovo-32

<400>  522

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Leu Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Asn Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Leu Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr Ser Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Lys Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Arg Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Leu Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Val His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Asn Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Thr Trp Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser His Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  523
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain Pasteur vaccins / PV

<400>  523
acgtgagatc gccaccatgg tcccccaggc cctgctgttc gtgccactgc tggtgtttcc       60

tctctgcttc ggaaaattcc ctatctacac catccccgat aagctgggcc catggagccc      120

catcgacatc caccacctga gctgccccaa caacctggtg gtggaggacg agggctgtac      180

caacctgtcc ggctttagct acatggaact gaaggtgggc tacatcagcg ccatcaagat      240

gaacggcttc acatgtacag gcgtggtgac cgaggctgaa acttatacca acttcgtggg      300

ctatgtgaca accacattca agagaaagca cttccgcccc acccctgatg catgtagagc      360

cgcttacaac tggaagatgg ccggcgaccc tagatacgag gaaagcctgc ataatcctta      420

ccccgactac cactggctga gaacagtgaa gaccaccaag gaatctctgg ttatcatctc      480

accttctgtg gctgacctgg acccctacga cagatccctg cacagcagag tgttccctgg      540

cggcaattgc agcggcgtgg ccgtgtcttc tacatactgc agcacaaacc acgactacac      600

catctggatg cctgagaacc ccagactggg catgagctgc gacatcttca ccaatagccg      660

gggcaagcgg gccagcaagg gcagcgagac ctgtggcttc gtggacgaga gaggcctgta      720

caagagcctg aagggagcct gtaaactgaa gctgtgcggc gtgctgggcc tgcggctgat      780

ggacggcacc tgggtggcca tgcagaccag caacgaaacc aagtggtgcc cacctggaca      840

gctggtgaac ctccatgatt ttcggagcga tgagatcgag caccttgtgg tcgaggaact      900

ggtgaaaaag cgggaagagt gcctggatgc cctggaaagc atcatgacca ccaaaagcgt      960

gtccttcaga agactgtctc acctgagaaa gttggtgcct ggctttggga aggcctacac     1020

catctttaac aagaccctga tggaagccga cgcccactac aagagcgtga ggacctggaa     1080

cgagatcatt ccaagcaagg gctgcctgag agtgggcggt agatgccacc ctcacgtgaa     1140

cggcgtgttc ttcaacggca tcatcctggg ccctgatggc aacgtgctga tccctgagat     1200

gcaatctagc ctgctgcagc agcacatgga actcctggtg tccagcgtga tccctctcat     1260

gcaccccctg gccgatcctt ccacagtgtt caagaacggc gatgaagctg aggacttcgt     1320

tgaggtgcac ctgcctgacg tgcacgagcg gatcagcgga gtggacctgg gactgcctaa     1380

ttggggcaaa tacgtgctgc tgagcgccgg cgccctgacc gccctgatgc tgatcatctt     1440

cctgatgaca tgctggcgga gagtgaatag aagcgagcct acccagcaca acctgcgggg     1500

caccggaaga gaagtgtccg ttacacctca gagcggcaag atcattagca gctgggagtc     1560

ctacaaatct ggcggagaga caggactgtg aattcacccc accagtg                   1607


<210>  524
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain Pasteur vaccins / PV

<400>  524

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Met Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Arg Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Asn Cys Ser Gly Val Ala Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Gly Met Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Glu 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Val Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asn Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Glu Arg Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Ala Leu Thr Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Trp 
465                 470                 475                 480 


Arg Arg Val Asn Arg Ser Glu Pro Thr Gln His Asn Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Glu Val Ser Val Thr Pro Gln Ser Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Gly Leu 
        515                 520                 


<210>  525
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain PM1503/AVO1

<400>  525
acgtgagatc gccaccatgg tgcctcaggt gcttctgttc gtgcccctgc tgggcttcag       60

cctgtgcttc ggaaagttcc ctatctacac catccctgat gagctgggac cttggtcccc      120

aatcgacatc caccacctca gctgccctaa caacctggtg gtggaagatg agggctgcac      180

caacctgagc gagttcagct acatggagct gaaggtggga tacatctccg ccatcaaggt      240

gaacggcttt acctgtaccg gcgtggtgac agaagctgaa acctacacaa atttcgtggg      300

ctacgtgaca acaaccttca agagaaagca cttccggccc acccctgacg cttgccgggc      360

tgcttataac tggaagatgg ccggtgaccc cagatacgag gaatccctgc acaaccctta      420

tcctgattac cactggctga ggaccgtgcg gaccaccaaa gagtccctga tcattatcag      480

ccctagcgtg accgacctgg acccttacga caagagcctg cattctagag gctttccagg      540

tggcaagtgc agcggcatca cagtgtctag cacctactgc agcaccaacc acgactacac      600

catctggatg cctgagaacc ccggccctag aaccccgtgc gacatcttca ccaacagcag      660

aggcaaaagg gccagcaagg gcaacaagac atgcggcttc gtggatgaga gaggcctgta      720

caagtccctg aagggcgcct gtcggctgaa gctctgtggc gtgctgggac tgcggttgat      780

ggacggcaca tgggtcgcca tgcaaacatc tgatgagaca aagtggtgcc cccccgacca      840

gctggtcaac ctgcacgatt tcagatctga cgagatcgag cacctggtgg ttgaggaact      900

ggtgaagaaa cgggaagagt gcctggacgc cctggaatcc atcatgacaa caaagagcgt      960

ctccttccgc agactgagcc acctgagaaa gctggtgcct ggctttggca aggcctacac     1020

catctttaac aagacactga tggaagccga cgcccactac aagtctgtgc gaacctggaa     1080

cgagattatc cccagcaaag gctgtctgaa agttggaggc agatgccacc cccacgtgaa     1140

tggagtcttt ttcaacggca tcatcctggg ccctgacggc cacgtgctga tccccgagat     1200

gcagtctagc ctgctgcagc agcacatgga actgctgaag agcagcgtca tcccactgat     1260

gcaccctctg gccgaccctt caacagtgtt caaggaagga gatgaagccg aggacttcgt     1320

ggaagtgcat ctgcctgatg tgtacaaaca gatcagcggc gtggacctgg gcctgccaaa     1380

ttggggcaag tacgtgctga tgaccgccgg cgccatgatc ggcctggtgc tgatcttcag     1440

cctgatgacc tggtgtagaa gagccaatag acctgagtct aagcagagaa gcttcggcgg     1500

caccggacgg aacgtgtccg tgaccagcca gagcgggaaa gtgatcccta gctgggaatc     1560

atatagaagc ggcggcgaga tccggctgtg aattcacccc accagtg                   1607


<210>  526
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain PM1503/AVO1

<400>  526

Met Val Pro Gln Val Leu Leu Phe Val Pro Leu Leu Gly Phe Ser Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Glu Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Glu Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Arg Thr Thr Lys Glu Ser Leu Ile Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Gly Phe Pro Gly Gly 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Gly Pro Arg Thr Pro Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Asn Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Arg Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Lys Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Glu Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Tyr Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Met Thr Ala 
    450                 455                 460                 


Gly Ala Met Ile Gly Leu Val Leu Ile Phe Ser Leu Met Thr Trp Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Pro Glu Ser Lys Gln Arg Ser Phe Gly Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Arg Ser Gly Gly Glu Ile Arg Leu 
        515                 520                 


<210>  527
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain China/DRV

<400>  527
acgtgagatc gccaccatgg tgccccaagc cctgctgctg gtgcctctgc tgggcttttc       60

cctgtgcttc ggcaagttcc ccatctacac catccccacc aaactgggac cttggagccc      120

tatcgacatc caccacctga gctgccccaa caacctggtg gtggaggatg agggatgcac      180

aaacctgagc ggcttcagct acatggaact gaaggtggga agaatcagcg ccatcaaggt      240

caacggcttc acctgtacag gcgtggtgac cgaggctgaa acatacacaa atttcgtggg      300

atacgtgacc accactttta agagaaagca cttcagacct atgcccggct gcatgtacag      360

ccgggtgcag ctggaagatg gtcgctcccc tcaaatcgag gaatctctgc acaaccccta      420

tcctgattac cactggctga gaaccgtgcg gaccacaaag gaatccctga tcattatctc      480

tccaagcgtg accgacctgg atccttacga caagagcctg cacagcaggg tgttcccagg      540

cagaaagtgc agcgggatca cagtgagcag cacctactgc agcaccaatc acgattatac      600

agtgtggatg cctgagatcc tgcggctggg aacatcttgt gacatcttta caaatagcag      660

aggaaagaga gcctctaagg gcagcaagac ctgcggcttc gtggacgaga gaggcctgta      720

caagtccctg aaaggcgcct gcaagctgaa gctctgtggc gtgcctggcc tcagactgat      780

ggacggcacc tgggtcgcca tgcagaccag caacgagaca aagtggtgcc ctcctggcca      840

gctggtgaac ctgcacgacc tgcatagcga cgaaattgag cacctggtgg tggaagagct      900

ggtgaagaaa agagaggaat gcctggacgc cctggaaagc attaccacaa ccaagagcgt      960

ctccttccgg agactgagcc acctgagaaa gctggtgcct ggctttggaa aggcctacac     1020

catcttcaac aagaccctga tggaagctga ggctcactac aagagcgtgc ggacctggaa     1080

cgagatcatc ccatctaaag gctgccttcg ggttggcggc ggatgtcacc cccacgtgaa     1140

tggcgttttc ttcaacggca tcatcctggg ccctgatggc cacgtgctga tccctgagat     1200

gcagtcttct ctcctgcagc agcacatcga gctgctggaa agcagcgtga tccccctgat     1260

gcaccctctg gccgacccat tcaccgtttt caaagacggc gacgagatcg aggatttcgt     1320

ggaagtgcat ctgcccgacg tgcacgagca ggtgtctggc gtcgacctgg gcctgcctaa     1380

ctggggcgag tacgtgctcc tgagcgccgg cacactgatc gccctgatgc tgatcatctt     1440

tctgatcacc tgctgtaaaa gagtggatag acccgagtct acacagcgga gcctgagagg     1500

caccggaagg aacgtgtccg tgaccagcca gagcggcaag ttcatcccta gcagagaatc     1560

ttacaagtcc ggcggcgaga ccggcctgtg aattcacccc accagtg                   1607


<210>  528
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain China/DRV

<400>  528

Met Val Pro Gln Ala Leu Leu Leu Val Pro Leu Leu Gly Phe Ser Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Thr Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Arg Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Met Pro Gly Cys 
            100                 105                 110         


Met Tyr Ser Arg Val Gln Leu Glu Asp Gly Arg Ser Pro Gln Ile Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Arg Thr Thr Lys Glu Ser Leu Ile Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Arg 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Val Trp Met Pro Glu Ile Leu Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Pro Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asn Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Leu His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Thr Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Gly Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Ile Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Phe Thr Val Phe Lys Asp Gly Asp Glu Ile Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Glu Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Glu Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Thr Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Ile Thr Cys Cys 
465                 470                 475                 480 


Lys Arg Val Asp Arg Pro Glu Ser Thr Gln Arg Ser Leu Arg Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Thr Ser Gln Ser Gly Lys Phe Ile Pro Ser 
            500                 505                 510         


Arg Glu Ser Tyr Lys Ser Gly Gly Glu Thr Gly Leu 
        515                 520                 


<210>  529
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain China/MRV

<400>  529
acgtgagatc gccaccatgg tgccccaggt gctgctgttc gtgttactgc tgggattcag       60

cctgtgtttt ggcaagttcc caatctacac catccccgac gagctgggcc cttggagccc      120

tatcgacatc caccacctgt cctgccccaa caacctggtc gtcgaggacg agggctgtac      180

caacctgagc gagttcagct acatggagct gaaggtgggc tacatcagcg ccatcaaggt      240

gaatggattt acctgtacag gcgtggtgac cgaggccgag acatacacaa acttcgtggg      300

ttatgtgacc accaccttca agagaaagca cttcagacct acacctgacg cgtgcagagc      360

tgcttacaac tggaagatgg ccggagatcc tagatacgag gaatccctgc ataatcctta      420

tcctgattac cactggctgc ggaccgtgcg gacaaccaag gaaagcctga tcatcatcag      480

ccctagcgtt accgacctgg acccctacga caagagcctg cacagcagag tgttccccgg      540

cagaaagtgc agcggcatca ccgtgtccag cacctactgc agcaccaacc acgactacac      600

catctggatg cctgagaacc cccggcctag aacaccgtgc gacatcttca ccaacagcag      660

aggaaaacgc gcttctaacg gcaacaagac atgtggcttc gtggacgaaa gaggcctgta      720

caaaagcctc aagggcgctt gtagactgaa gctgtgcggc gtgctgggcc tgagactgat      780

ggacggcacc tgggtggcca tgcagaccag cggagaaacc aaatggtgcc cacctgatca      840

gctggtgaac cttcatgatt ttagatctga tgagatcgag cacctggtgg tggaagagct      900

ggtcaagaag cgggaggaat gcctggatgc cctggagagc atcatgacca caaagtctgt      960

ctcctttcgg agactgagcc acctgagaaa actggttcct ggcttcggca aggcctacac     1020

catctttaac aagaccctga tggaagccga cgcccactac aagtccgtgc ggacatggaa     1080

tgagattatc ccctctaaag gctgcctgaa agtgggcgga agatgccacc cccacgtgaa     1140

cggtgtgttc ttcaacggcc tgatcctggg acctgacgac cacgtgctga tcccagaaat     1200

gcagagcagc ctgctgcagc aacacatgga actgctggaa tcttctgtga tccctctgat     1260

gcaccctctg gccgatcctt ctacagtgtt caaggaaggc gacgaggccg aggatttcgt     1320

tgaagtgcac ctgcctgacg tgtacaagca gatcagcggc gtggacctgg gccttcctaa     1380

ctggggcaaa tacgtgctga tgacagccgg cgccatgatc ggcctggtgc tcatcttcag     1440

cctgatgacc tggtgcaggc gggccaacag acccgagtcc aagcagagaa gcttcggcgg     1500

cacaggcgga aatgtgtctg tgacatctca gagcggcaag gtgatcccaa gctgggagtc     1560

atacaagagc gggggcgaga ttcggctgtg aattcacccc accagtg                   1607


<210>  530
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain China/MRV

<400>  530

Met Val Pro Gln Val Leu Leu Phe Val Leu Leu Leu Gly Phe Ser Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Glu Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Glu Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Arg Thr Thr Lys Glu Ser Leu Ile Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Arg 
                165                 170                 175     


Lys Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Arg Thr Pro Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly Asn Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Arg Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Gly Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Leu Ile Leu 
    370                 375                 380                 


Gly Pro Asp Asp His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Glu Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val Tyr Lys Gln Ile Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Met Thr Ala 
    450                 455                 460                 


Gly Ala Met Ile Gly Leu Val Leu Ile Phe Ser Leu Met Thr Trp Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Pro Glu Ser Lys Gln Arg Ser Phe Gly Gly Thr 
                485                 490                 495     


Gly Gly Asn Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Pro Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Ile Arg Leu 
        515                 520                 


<210>  531
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus isolate Human/Algeria/1991

<400>  531
acgtgagatc gccaccatgg tgcctcaggc cctgttgttc gtgcccctgc tggtgttccc       60

cctgtgcttc ggcaagttcc ctatctacac cattccagac aagctgggcc cttggtcccc      120

aatcgacatc caccacctgc ggtgccctaa caacctggtg gtcgaggacg agggctgtac      180

caacctgagc ggattcagct acatggaact gaaagtgggc tacatcagcg ccatcaaggt      240

gaatggcttc acctgtaccg gcgtggtgac cgaggccgag acatacacca acttcgtggg      300

ctatgtcaca acaactttta agagaaagca cttccggcct acccctgatg cttgtagagc      360

cgcttacaac tggaagatgg ccggcgaccc tagatacgag gaatccctgc acaaccctta      420

tcctgattac cactggctga gaaccgtgaa gaccacaaag gaaagcctgg tgatcatcag      480

ccctagcgtg gccgatctgg atccttacga caagtccctg cacagcagag tgtttccttc      540

tggcaactgc agcggaatca cagtttctag cacatactgc agcaccaacc acgactacac      600

catctggatg cctgagaacc ccagactgga aaccagctgc gacatcttca ccaatagccg      660

gggcaagaga gcctctaagg gcagcaagac atgcggcttc gtggacgaga gaggcctgta      720

caaaagcctg aagggcgcct gcaaactgaa actgtgtggc gtgctgggac tgagactgat      780

ggacggcacc tgggtggcca tgcaaacatc agatgaaacc aaatggtgcc cacctgacca      840

gctggtgaac ctgcatgact tcagaagcga cgaaatcgag cacctggtgg tggaagagct      900

ggtgaaaaag cgggaagagt gcctggacgc cctggaaagc atcatgacca ccaagagcgt      960

ctccctgaga cggctttctc acctgagaaa gctggtcccc ggctttggca aggcctacac     1020

aatctttaac aagaccctga tggaagctga ggcccactac aagagcgtgc agacctggaa     1080

cgagatcatc cccagcaagg gttgtctgag ggtgggcggc agatgccacc cccacgtgaa     1140

tggagtgttc ttcaatggca tcatcctggg acctgatggc cacgtgctga ttccagagat     1200

gcagagctct ctgctccagc agcacatgga attactcgag agcagcgtga tccctctgat     1260

gcaccctctg gccgacccct ctaccgtgtt taaggacgga gatgaagccg aggatttcgt     1320

tgaagtgcac ctgcctgacg tgcataagca ggtgtccgga gtggacctgg gcctgcccaa     1380

ctggggcaag tacgtgctgc tgagcgctgg cacactgatc gccctgatgc tgatcatctt     1440

cctgatgacc tgctgcagac gcgtgaacag acctaagtcc accgagcgga gcctgggcga     1500

gacaggccgg aaggtgtccg tgaccagcca gtctggcaaa gtgatcagca gctgggagtc     1560

ttacaagagc ggaggcgaga caagacggtg aattcacccc accagtg                   1607


<210>  532
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus isolate Human/Algeria/1991

<400>  532

Met Val Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Arg Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Asn Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Leu Glu Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Lys Gly Ser Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Leu Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Glu Ala His Tyr Lys Ser Val Gln 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Asn Trp Gly Lys Tyr Val Leu Leu Ser Ala 
    450                 455                 460                 


Gly Thr Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Pro Lys Ser Thr Glu Arg Ser Leu Gly Glu Thr 
                485                 490                 495     


Gly Arg Lys Val Ser Val Thr Ser Gln Ser Gly Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Arg Arg 
        515                 520                 


<210>  533
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain HEP-Flury

<400>  533
acgtgagatc gccaccatgg tcccccaggt gctgctgttc gcccctctgc tggtgtttcc       60

actgtgcttc ggcaagttcc ctatctacac aatccctgac aagctcggac cttggtcccc      120

tatcgacctg caccacctgt cctgccccaa caacctggtg gtcgaggacg aaggctgtac      180

caatctgagc ggattcagct acatggagct gaaggtgggc tacatcagcg ccatcaaggt      240

gaacggcttc acatgtacag gcgtggtgac agaggccgaa acatacacca acttcgtggg      300

ctatgtgacc acaacattca aaagaaagca cttcagaccg acccctgatg cctgcagagc      360

cgcttacaac tggaagatgg ccggcgatcc tagatacgag gagtctctgc ataatcctta      420

tcctgattac cactggctgc ggaccgtgaa gacaaccaag gaatctctgg tgatcatttc      480

tccttctgtg acagacctgg atccttacga caagagcctg cacagcagag tcttccccgg      540

cggcaactgc agcggcatca ccgtgtccag cacatactgc agcaccaacc acgactacac      600

catctggatg cctgagaacc tgcggctggg cactagctgc gacatcttta cccactctag      660

aggcaaacgg gccagcaagg gagataagac ctgtggcttt gtggatgaac ggggcctgta      720

caaatccctg aagggagcct gtaaactgaa actgtgcggc gtgctgggtc tgcgcctgat      780

ggacgggacc tgggtggcca tgcaaaccag cgacgagaca aagtggtgcc ctcctggcca      840

gctggtcaac ctccatgatt tcagaagcga cgagatcgag cacctggtgg aagaggagct      900

tgttaagaag agagaagagt gcctggacgc tctggaatcc atcatgacca caaaaagcgt      960

gtcttttcgg cggctgagcc acctgaggaa gctggtgccc ggcttcggca aggcctacac     1020

catcttcaac aagaccctga tggaagctga tgcccactac aaaagcgtgc agacctggaa     1080

cgagatcatc ccttctaagg gatgtctgcg agtgggcgag cggtgccacc ctcacgtgaa     1140

tggcgttttc ttcaacggca tcatcctggg atctgacggc cacgtgctga ttccagagat     1200

gcagagcagc ctgctgcaac agcacatgga gctgctggaa agcagcgtga tccccctgat     1260

gcaccccctg gccgacccca gcaccgtgtt caaggacggc gacgaggtgg aagattttgt     1320

ggaagtccac ttgcctgacg tgcacaagca ggtgtccggc gtggacctgg gcctacccaa     1380

gtggggaaag tacgtgctga tgatcgctgg cgccctgatc gccctgatgc tgattatctt     1440

cctgatgacc tgctgcagaa gagtgaacag acctgagagc acccagtcta atctgggtgg     1500

caccggcaga aacgtgtccg tgcctagcca gagcggcaag gtgatcagca gctgggagag     1560

ctacaagagc ggcggagaaa ccagactgtg aattcacccc accagtg                   1607


<210>  534
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain HEP-Flury

<400>  534

Met Val Pro Gln Val Leu Leu Phe Ala Pro Leu Leu Val Phe Pro Leu 
1               5                   10                  15      


Cys Phe Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Leu His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Asn Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Ile Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Thr Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala Tyr Asn Trp Lys Met Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Glu Ser Leu His Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Thr Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Gly Gly 
                165                 170                 175     


Asn Cys Ser Gly Ile Thr Val Ser Ser Thr Tyr Cys Ser Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Glu Asn Leu Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr His Ser Arg Gly Lys Arg Ala Ser Lys Gly Asp Lys 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Leu Gly Leu Arg Leu Met Asp 
                245                 250                 255     


Gly Thr Trp Val Ala Met Gln Thr Ser Asp Glu Thr Lys Trp Cys Pro 
            260                 265                 270         


Pro Gly Gln Leu Val Asn Leu His Asp Phe Arg Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Glu Glu Glu Leu Val Lys Lys Arg Glu Glu Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Lys Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Gln 
            340                 345                 350         


Thr Trp Asn Glu Ile Ile Pro Ser Lys Gly Cys Leu Arg Val Gly Glu 
        355                 360                 365             


Arg Cys His Pro His Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Ser Asp Gly His Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Val Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Val Ser Gly 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Lys Trp Gly Lys Tyr Val Leu Met Ile Ala 
    450                 455                 460                 


Gly Ala Leu Ile Ala Leu Met Leu Ile Ile Phe Leu Met Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Val Asn Arg Pro Glu Ser Thr Gln Ser Asn Leu Gly Gly Thr 
                485                 490                 495     


Gly Arg Asn Val Ser Val Pro Ser Gln Ser Gly Lys Val Ile Ser Ser 
            500                 505                 510         


Trp Glu Ser Tyr Lys Ser Gly Gly Glu Thr Arg Leu 
        515                 520                 


<210>  535
<211>  1607
<212>  DNA
<213>  Lyssavirus Rabies virus strain silver-haired bat-associated

<400>  535
acgtgagatc gccaccatga tcccacaggc cctgctgttc gtgcccctgc tgatccccag       60

cctgtgtctg ggcaaattcc ccatctacac cattcctgat aagctgggcc cttggagccc      120

tatcgacatc caccacctga gctgccccaa caacctggtg gtcgaggacg agggctgtac      180

tagcctgtcc ggatttagct acatggagct gaaggtgggc tacatcagcg ccatgaaagt      240

gaacggattc acctgcaccg gcgtggtgac cgaggccgag acatacacca acttcgtcgg      300

atacgtcaca acaacattca agcggaagca cttcagacct atgccagacg cctgcagagc      360

tgctcacgac tggaagatcg ccggcgatcc acggtacgag gacagcctgc aaaatcctta      420

tcctgattac cactggctga ggacagtgaa gaccaccaag gaaagcctag tgatcatcag      480

tccttctgtg gctgatctgg atccttacga caagagcctg cattctagag tgtttcctag      540

cggcaagtgc ctgggtatca ccgtgtctag cacctactgc cctacaaatc acgattacac      600

tatctggatg cctgtggaag ccagactggg aacaagttgc gacatcttta ccaacagccg      660

gggcaagaag gccagcaaag gcggaagaac ctgtggcttt gtggacgaaa gaggccttta      720

taagagcctg aagggcgcct gtaaactgaa gttgtgcgga gttcctggcc tgagactgat      780

gaacggcaca tgggtgtcca tccagaccag cgacgacatc aagtggtgcc ctcccgatca      840

gctggttaat ctgcacgact tccactctga cgagatcgag cacctggtgg tggaggaact      900

gatcaagaaa agagaaggat gtctcgatgc cctggaaagc atcatgacca caaagtccgt      960

ctccttccgg cgcctgagcc acctgagaaa gctggtcccc ggcttcggca aagcctacac     1020

catcttcaac aacaccctga tggaagccga cgcgcactac aagtctgtta gaacctggaa     1080

cgaggtgatc ccttctaaag gctgcctgaa ggtgggaggc agatgccacc ctcctgtgaa     1140

cggcgtgttc ttcaacggca tcatcctggg cccagacggc aacgtgctga tccctgagat     1200

gcagagctct ctgctgcagc agcacatgga actgctcgaa agcagcgtga tccccctgat     1260

gcaccccctg gctgacccct ccaccgtgtt caaggacggc gacgaggctg aagatttcgt     1320

ggaagtgcac ctgcccgacg tgcataagca ggtgtccgac gtggacctgg gcctgcctag     1380

ctggggcaag tacctgctca tgagcgccgg agccctggcc accctgattc tggccatctt     1440

cctgattaca tgctgcagac gggccaatcg gaccaagtct acccagcggg gccacagaga     1500

gagcggcggc aaggtgagcg tggcccctca aaacggcaaa atcatcagca gctgggagct     1560

gtacaagagc gagagcgaga caggcatgtg aattcacccc accagtg                   1607


<210>  536
<211>  524
<212>  PRT
<213>  Lyssavirus Rabies virus strain silver-haired bat-associated

<400>  536

Met Ile Pro Gln Ala Leu Leu Phe Val Pro Leu Leu Ile Pro Ser Leu 
1               5                   10                  15      


Cys Leu Gly Lys Phe Pro Ile Tyr Thr Ile Pro Asp Lys Leu Gly Pro 
            20                  25                  30          


Trp Ser Pro Ile Asp Ile His His Leu Ser Cys Pro Asn Asn Leu Val 
        35                  40                  45              


Val Glu Asp Glu Gly Cys Thr Ser Leu Ser Gly Phe Ser Tyr Met Glu 
    50                  55                  60                  


Leu Lys Val Gly Tyr Ile Ser Ala Met Lys Val Asn Gly Phe Thr Cys 
65                  70                  75                  80  


Thr Gly Val Val Thr Glu Ala Glu Thr Tyr Thr Asn Phe Val Gly Tyr 
                85                  90                  95      


Val Thr Thr Thr Phe Lys Arg Lys His Phe Arg Pro Met Pro Asp Ala 
            100                 105                 110         


Cys Arg Ala Ala His Asp Trp Lys Ile Ala Gly Asp Pro Arg Tyr Glu 
        115                 120                 125             


Asp Ser Leu Gln Asn Pro Tyr Pro Asp Tyr His Trp Leu Arg Thr Val 
    130                 135                 140                 


Lys Thr Thr Lys Glu Ser Leu Val Ile Ile Ser Pro Ser Val Ala Asp 
145                 150                 155                 160 


Leu Asp Pro Tyr Asp Lys Ser Leu His Ser Arg Val Phe Pro Ser Gly 
                165                 170                 175     


Lys Cys Leu Gly Ile Thr Val Ser Ser Thr Tyr Cys Pro Thr Asn His 
            180                 185                 190         


Asp Tyr Thr Ile Trp Met Pro Val Glu Ala Arg Leu Gly Thr Ser Cys 
        195                 200                 205             


Asp Ile Phe Thr Asn Ser Arg Gly Lys Lys Ala Ser Lys Gly Gly Arg 
    210                 215                 220                 


Thr Cys Gly Phe Val Asp Glu Arg Gly Leu Tyr Lys Ser Leu Lys Gly 
225                 230                 235                 240 


Ala Cys Lys Leu Lys Leu Cys Gly Val Pro Gly Leu Arg Leu Met Asn 
                245                 250                 255     


Gly Thr Trp Val Ser Ile Gln Thr Ser Asp Asp Ile Lys Trp Cys Pro 
            260                 265                 270         


Pro Asp Gln Leu Val Asn Leu His Asp Phe His Ser Asp Glu Ile Glu 
        275                 280                 285             


His Leu Val Val Glu Glu Leu Ile Lys Lys Arg Glu Gly Cys Leu Asp 
    290                 295                 300                 


Ala Leu Glu Ser Ile Met Thr Thr Lys Ser Val Ser Phe Arg Arg Leu 
305                 310                 315                 320 


Ser His Leu Arg Lys Leu Val Pro Gly Phe Gly Lys Ala Tyr Thr Ile 
                325                 330                 335     


Phe Asn Asn Thr Leu Met Glu Ala Asp Ala His Tyr Lys Ser Val Arg 
            340                 345                 350         


Thr Trp Asn Glu Val Ile Pro Ser Lys Gly Cys Leu Lys Val Gly Gly 
        355                 360                 365             


Arg Cys His Pro Pro Val Asn Gly Val Phe Phe Asn Gly Ile Ile Leu 
    370                 375                 380                 


Gly Pro Asp Gly Asn Val Leu Ile Pro Glu Met Gln Ser Ser Leu Leu 
385                 390                 395                 400 


Gln Gln His Met Glu Leu Leu Glu Ser Ser Val Ile Pro Leu Met His 
                405                 410                 415     


Pro Leu Ala Asp Pro Ser Thr Val Phe Lys Asp Gly Asp Glu Ala Glu 
            420                 425                 430         


Asp Phe Val Glu Val His Leu Pro Asp Val His Lys Gln Val Ser Asp 
        435                 440                 445             


Val Asp Leu Gly Leu Pro Ser Trp Gly Lys Tyr Leu Leu Met Ser Ala 
    450                 455                 460                 


Gly Ala Leu Ala Thr Leu Ile Leu Ala Ile Phe Leu Ile Thr Cys Cys 
465                 470                 475                 480 


Arg Arg Ala Asn Arg Thr Lys Ser Thr Gln Arg Gly His Arg Glu Ser 
                485                 490                 495     


Gly Gly Lys Val Ser Val Ala Pro Gln Asn Gly Lys Ile Ile Ser Ser 
            500                 505                 510         


Trp Glu Leu Tyr Lys Ser Glu Ser Glu Thr Gly Met 
        515                 520                 


<210>  537
<211>  2715
<212>  DNA
<213>  Simplexvirus Herpes simplex virus type 2

<400>  537
atgcggggtg gcggactgat atgtgcactg gtagttgggg cattggtggc agctgtcgca       60

tctgccgctc ctgccgcgcc agcagctcct cgtgcttcag gtggggtagc tgctactgtg      120

gcagccaatg gcgggcctgc aagtcgtcca ccacctgtac cttcccctgc cacgacgaaa      180

gctaggaaaa gaaagacaaa gaaaccccca aaacgcccgg aagccacacc accgcctgat      240

gctaatgcca cagtggctgc aggacatgct acactccgag cacatcttag agagattaaa      300

gtggaaaatg ctgacgctca attctatgtt tgtcccccac caacaggagc taccgtcgtt      360

caattcgaac aacccagacg atgtcccacc cggccagaag gacaaaatta tactgaaggt      420

attgccgtcg tgtttaaaga aaatattgca ccctataagt ttaaagcaac tatgtattac      480

aaggacgtca cagtctccca agtatggttt ggacatcggt atagccaatt catgggcatc      540

tttgaagata gggcacctgt gccttttgaa gaagtcatag ataaaatcaa tgctaaaggc      600

gtgtgtcgtt ctactgcaaa atatgtacgc aataatatgg aaactacagc cttccataga      660

gatgatcatg aaactgatat ggaactgaaa cccgcaaaag tagcaacccg gacaagtcga      720

ggatggcata caacggattt gaaatataat ccttctcgag tagaagcctt tcacaggtat      780

ggtaccaccg ttaattgtat agttgaagaa gttgatgcta ggagcgttta tccatatgac      840

gaattcgttc tggccacagg agatttcgtt tatatgagcc cattctatgg atatagagaa      900

ggttctcata ctgaacatac gtcctatgca gcagatcgat ttaaacaagt ggatggattt      960

tatgcccggg atctgacgac aaaagcacga gcaacctcac ctaccacaag aaatcttctc     1020

actacaccaa aattcacagt cgcgtgggat tgggtaccta aaagacccgc cgtttgtaca     1080

atgactaaat ggcaagaagt cgatgaaatg ttgcgtgcag aatatggcgg aagctttagg     1140

ttttcatctg atgcaattag cactacattt actacgaatc tcacgcaata tagtctgtct     1200

agagtggatc ttggtgattg tatagggcgc gacgcaagag aagctattga tcgaatgttc     1260

gcaagaaaat ataatgctac ccatataaaa gttgggcaac cacaatatta tttggcgaca     1320

ggcggttttc tgatagccta tcaaccactg ctgtccaata ccttggctga actctatgtt     1380

agggaatata tgagagaaca agataggaaa ccaaggaacg cgaccccagc acctcttagg     1440

gaagctccat ctgcaaatgc tagcgttgaa agaattaaaa caacatcttc catagaattt     1500

gcaaggttgc aattcacata caatcatatt caacggcatg ttaatgatat gctcggccgg     1560

attgctgtgg catggtgtga acttcaaaat catgaactca cgctgtggaa tgaagcgagg     1620

aaactgaatc ctaatgctat tgctagtgct acggttggaa ggcgagtttc agctagaatg     1680

cttggtgatg tgatggctgt ttcaacttgt gtaccggtgg cacccgataa tgtcattgtt     1740

caaaattcca tgcgggtatc atcaagacca ggtacatgtt atagtcggcc gctcgtgtcc     1800

ttcagatatg aggatcaagg accacttatt gaaggacaac ttggtgaaaa taatgaactt     1860

cggctgacta gagatgcttt ggaaccatgt acagttggtc atcgtcggta ttttattttc     1920

ggaggaggtt atgtttattt tgaagaatat gcttatagcc atcagttgtc cagggctgat     1980

gtgactacag tgtctacatt tattgatctt aacataacta tgctcgaaga tcatgaattc     2040

gtcccacttg aagtgtatac ccgtcatgaa attaaagatt ctggtctcct tgattatacc     2100

gaagtacaac ggcggaatca actccatgat ctcagattcg ctgatattga tacagtaatt     2160

cgggcagatg caaatgctgc tatgtttgca ggtctttgtg ccttcttcga aggcatggga     2220

gatctgggtc gggccgttgg gaaagtggtg atgggcgtgg tcggcggagt cgtatctgcg     2280

gtttctgggg tttcaagttt catgagtaat ccttttggcg ccctggcagt tggcctgctc     2340

gtacttgcgg gtcttgtagc cgcgttcttc gcgtttcggt atgtgcttca gcttcagagg     2400

aaccctatga aagcgctcta ccccctgaca actaaagagc tgaaaacgtc tgatcctggt     2460

ggggtcggcg gagaaggaga agagggagca gaaggcggcg gattcgatga agcaaaactc     2520

gctgaagcta gggagatgat aagatacatg gcgcttgtaa gtgcgatgga acggactgag     2580

cataaagctc gtaagaaagg aacttctgct ctcctgtctt ctaaagtaac taatatggtc     2640

ttgcggaaaa ggaataaggc acgatattct cccctgcata atgaagatga agcaggcgat     2700

gaggatgaac tgtga                                                      2715


<210>  538
<211>  904
<212>  PRT
<213>  Simplexvirus Herpes simplex virus type 2

<400>  538

Met Arg Gly Gly Gly Leu Ile Cys Ala Leu Val Val Gly Ala Leu Val 
1               5                   10                  15      


Ala Ala Val Ala Ser Ala Ala Pro Ala Ala Pro Ala Ala Pro Arg Ala 
            20                  25                  30          


Ser Gly Gly Val Ala Ala Thr Val Ala Ala Asn Gly Gly Pro Ala Ser 
        35                  40                  45              


Arg Pro Pro Pro Val Pro Ser Pro Ala Thr Thr Lys Ala Arg Lys Arg 
    50                  55                  60                  


Lys Thr Lys Lys Pro Pro Lys Arg Pro Glu Ala Thr Pro Pro Pro Asp 
65                  70                  75                  80  


Ala Asn Ala Thr Val Ala Ala Gly His Ala Thr Leu Arg Ala His Leu 
                85                  90                  95      


Arg Glu Ile Lys Val Glu Asn Ala Asp Ala Gln Phe Tyr Val Cys Pro 
            100                 105                 110         


Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu Gln Pro Arg Arg Cys 
        115                 120                 125             


Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu Gly Ile Ala Val Val 
    130                 135                 140                 


Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr Tyr 
145                 150                 155                 160 


Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly His Arg Tyr Ser Gln 
                165                 170                 175     


Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val Pro Phe Glu Glu Val 
            180                 185                 190         


Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg Ser Thr Ala Lys Tyr 
        195                 200                 205             


Val Arg Asn Asn Met Glu Thr Thr Ala Phe His Arg Asp Asp His Glu 
    210                 215                 220                 


Thr Asp Met Glu Leu Lys Pro Ala Lys Val Ala Thr Arg Thr Ser Arg 
225                 230                 235                 240 


Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala 
                245                 250                 255     


Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile Val Glu Glu Val Asp 
            260                 265                 270         


Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp 
        275                 280                 285             


Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr 
    290                 295                 300                 


Glu His Thr Ser Tyr Ala Ala Asp Arg Phe Lys Gln Val Asp Gly Phe 
305                 310                 315                 320 


Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala Thr Ser Pro Thr Thr 
                325                 330                 335     


Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val Ala Trp Asp Trp Val 
            340                 345                 350         


Pro Lys Arg Pro Ala Val Cys Thr Met Thr Lys Trp Gln Glu Val Asp 
        355                 360                 365             


Glu Met Leu Arg Ala Glu Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp 
    370                 375                 380                 


Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr Gln Tyr Ser Leu Ser 
385                 390                 395                 400 


Arg Val Asp Leu Gly Asp Cys Ile Gly Arg Asp Ala Arg Glu Ala Ile 
                405                 410                 415     


Asp Arg Met Phe Ala Arg Lys Tyr Asn Ala Thr His Ile Lys Val Gly 
            420                 425                 430         


Gln Pro Gln Tyr Tyr Leu Ala Thr Gly Gly Phe Leu Ile Ala Tyr Gln 
        435                 440                 445             


Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr Val Arg Glu Tyr Met 
    450                 455                 460                 


Arg Glu Gln Asp Arg Lys Pro Arg Asn Ala Thr Pro Ala Pro Leu Arg 
465                 470                 475                 480 


Glu Ala Pro Ser Ala Asn Ala Ser Val Glu Arg Ile Lys Thr Thr Ser 
                485                 490                 495     


Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His Ile Gln Arg 
            500                 505                 510         


His Val Asn Asp Met Leu Gly Arg Ile Ala Val Ala Trp Cys Glu Leu 
        515                 520                 525             


Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys Leu Asn Pro 
    530                 535                 540                 


Asn Ala Ile Ala Ser Ala Thr Val Gly Arg Arg Val Ser Ala Arg Met 
545                 550                 555                 560 


Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val Ala Pro Asp 
                565                 570                 575     


Asn Val Ile Val Gln Asn Ser Met Arg Val Ser Ser Arg Pro Gly Thr 
            580                 585                 590         


Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp Gln Gly Pro 
        595                 600                 605             


Leu Ile Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg Leu Thr Arg 
    610                 615                 620                 


Asp Ala Leu Glu Pro Cys Thr Val Gly His Arg Arg Tyr Phe Ile Phe 
625                 630                 635                 640 


Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser His Gln Leu 
                645                 650                 655     


Ser Arg Ala Asp Val Thr Thr Val Ser Thr Phe Ile Asp Leu Asn Ile 
            660                 665                 670         


Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val Tyr Thr Arg 
        675                 680                 685             


His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu Val Gln Arg 
    690                 695                 700                 


Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp Thr Val Ile 
705                 710                 715                 720 


Arg Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Cys Ala Phe Phe 
                725                 730                 735     


Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val Val Met Gly 
            740                 745                 750         


Val Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser Ser Phe Met 
        755                 760                 765             


Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val Leu Ala Gly 
    770                 775                 780                 


Leu Val Ala Ala Phe Phe Ala Phe Arg Tyr Val Leu Gln Leu Gln Arg 
785                 790                 795                 800 


Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu Leu Lys Thr 
                805                 810                 815     


Ser Asp Pro Gly Gly Val Gly Gly Glu Gly Glu Glu Gly Ala Glu Gly 
            820                 825                 830         


Gly Gly Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 
        835                 840                 845             


Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Arg 
    850                 855                 860                 


Lys Lys Gly Thr Ser Ala Leu Leu Ser Ser Lys Val Thr Asn Met Val 
865                 870                 875                 880 


Leu Arg Lys Arg Asn Lys Ala Arg Tyr Ser Pro Leu His Asn Glu Asp 
                885                 890                 895     


Glu Ala Gly Asp Glu Asp Glu Leu 
            900                 


<210>  539
<211>  1182
<212>  DNA
<213>  Simplexvirus Herpes simplex virus type 2

<400>  539
atggggcgtt tgacctccgg cgtcgggacg gcggccctgc tagttgtcgc ggtgggactc       60

cgcgtcgtct gcgccaaata cgccttagca gacccctcgc ttaagatggc cgatcccaat      120

cgatttcgcg ggaagaacct tccggttttg gaccagctga ccgacccccc cggggtgaag      180

cgtgtttacc acattcagcc gagcctggag gacccgttcc agccccccag catcccgatc      240

actgtgtact acgcagtgct ggaacgtgcc tgccgcagcg tgctcctaca tgccccatcg      300

gaggcccccc agatcgtgcg cggggcttcg gacgaggccc gaaagcacac gtacaacctg      360

accatcgcct ggtatcgcat gggagacaat tgcgctatcc ccatcacggt tatggaatac      420

accgagtgcc cctacaacaa gtcgttgggg gtctgcccca tccgaacgca gccccgctgg      480

agctactatg acagctttag cgccgtcagc gaggataacc tgggattcct gatgcacgcc      540

cccgccttcg agaccgcggg tacgtacctg cggctagtga agataaacga ctggacggag      600

atcacacaat ttatcctgga gcaccgggcc cgcgcctcct gcaagtacgc tctccccctg      660

cgcatccccc cggcagcgtg cctcacctcg aaggcctacc aacagggcgt gacggtcgac      720

agcatcggga tgttaccccg ctttactccc gaaaaccagc gcaccgtcgc cctatacagc      780

ttaaaaatcg ccgggtggca cggccccaag cccccgtaca ccagcaccct gctgccgccg      840

gagctgtccg acaccaccaa cgccacgcaa cccgaactcg ttccggaaga ccccgaggac      900

tcggccctct tagaggatcc cgccgggacg gtgtcttcgc agatcccccc aaactggcac      960

atcccgtcga tccaggacgt cgcgccgcac cacgcccccg ccgccccagc caacccgggc     1020

ctgatcatcg gcgcgctggc cggcagtacc ctggcggcgc tggtcatcgg cggtattgcg     1080

ttttgggtac gccgccggcg ctcagtggcc cccaagcgcc tacgtctccc ccacatccgg     1140

gatgacgacg cgcccccctc gcaccagcca ttgttttact ag                        1182


<210>  540
<211>  393
<212>  PRT
<213>  Simplexvirus Herpes simplex virus type 2

<400>  540

Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val 
1               5                   10                  15      


Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Leu Ala Asp Pro 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Pro Ser Leu Glu Asp Pro Phe Gln Pro Pro Ser Ile Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


His Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Asp Glu 
            100                 105                 110         


Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly 
        115                 120                 125             


Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Thr Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Leu Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Ala Gly Thr Val Ser Ser Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Val Ala Pro His His Ala Pro Ala Ala Pro 
                325                 330                 335     


Ala Asn Pro Gly Leu Ile Ile Gly Ala Leu Ala Gly Ser Thr Leu Ala 
            340                 345                 350         


Ala Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Arg Ser 
        355                 360                 365             


Val Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala 
    370                 375                 380                 


Pro Pro Ser His Gln Pro Leu Phe Tyr 
385                 390             


<210>  541
<211>  2517
<212>  DNA
<213>  Simplexvirus Herpes simplex virus type 2

<400>  541
atgggtccag gcttgtgggt tgtgatgggt gtgttggttg gtgtcgcagg cggacacgat       60

acctattgga ccgaacagat tgatccttgg ttcctgcatg ggcttggact tgcgaggacc      120

tattggagag ataccaatac aggacggctt tggctgccaa atactcctga tgcatccgat      180

cctcaaagag ggcggcttgc accaccaggt gagctgaatc tcacaactgc cagcgtccca      240

atgttgcgct ggtatgcaga acggttctgc tttgtcctcg taactacagc tgaattcccc      300

cgcgatcctg gacaactcct gtatattcct aaaacttacc tgctggggag accacgcaat      360

gcttctttgc cagaattgcc tgaagccggt ccgacaagca ggccaccagc agaagtcact      420

caactgaaag ggttgtctca taatccaggg gctagcgctc ttctcagaag tagagcatgg      480

gttacctttg ctgcagcccc agatagggaa ggactgacct ttccccgtgg cgatgatggc      540

gctacagaaa gacatcccga tggaaggaga aatgctccac cccctggtcc ccctgccggc      600

acaccccgac acccaacaac aaatctttcc atagcccacc tgcataatgc ttcagttact      660

tggttggcgg ctcggggttt gctgagaacc cctggcagat atgtctatct tagtcctagt      720

gcgagtacct ggcctgtcgg agtgtggacc accggtggcc ttgcctttgg atgtgatgcg      780

gcccttgtta gagccaggta tggaaaagga tttatgggct tggttattag tatgagagat      840

tctccccctg cagaaattat tgtagtacca gcagataaaa ctctggcgcg tgtggggaac      900

ccaactgatg agaatgcacc agctgtcctt cctggcccac ccgcgggacc tcgttacagg      960

gtgttcgtac tcggcgcgcc cacaccggca gataatgggt cagctctcga tgcactgaga     1020

cgtgttgctg ggtatcctga agaatctaca aattatgctc aatacatgag tagagcttac     1080

gccgaattcc tcggcgaaga tccaggtagc gggacagatg caaggccaag tctcttttgg     1140

cgcctggctg gcctcttggc ttcaagcgga ttcgcctttg ttaatgccgc tcatgcacat     1200

gatgcaatcc ggctgtcaga tctcctcggt ttcctggcgc attctagggt tcttgctggt     1260

ttggcggcac gaggggctgc aggatgtgcc gcagattcag tatttcttaa tgtatctgta     1320

cttgatcccg ctgctaggct cagattggaa gcacgactgg gccacctcgt cgcagctatt     1380

ttggaaagag aacaatccct cgtagcccat gcacttggtt accaacttgc ctttgttctg     1440

gatagtccag ccgcttacgg agccgtcgca ccaagtgccg cacggttgat tgatgctctt     1500

tatgctgaat tcctgggtgg tcgagcattg acagctccaa tggtaaggcg ggccttgttc     1560

tatgcgaccg cggttttgcg agcccctttt ctcgccggtg ccccaagcgc tgaacaaaga     1620

gagagggctc gaaggggatt gctgatcact accgctttgt gcacatcaga tgtagcagct     1680

gctactcatg ctgaccttcg tgcagccctg gcgcgcacgg atcatcaaaa gaatctgttt     1740

tggctgcctg atcatttctc accttgtgcc gcgtcactcc ggtttgacct tgcagaaggc     1800

ggatttatat tggatgcact tgcaatggct acacgcagtg atattccagc tgatgtaatg     1860

gcccagcaaa cacgcggggt cgctagcgtg ctgactaggt gggcccatta taatgctctt     1920

ataagagcat ttgtgcctga agctactcat caatgcagtg gtcccagcca taatgcagaa     1980

cctaggattc ttgtcccgat tactcataat gcatcctatg ttgtgactca tactcctctc     2040

ccaaggggaa ttggttataa attgaccgga gtcgatgtga gacgacctct tttcattacg     2100

tacctgactg ctacgtgtga gggtcatgcc agagaaatcg aaccaaagag actcgtccgg     2160

actgagaata ggcgagattt gggactggtc ggcgcagttt tcctgcgata tactcccgca     2220

ggagaagtta tgtccgtttt gctcgtagat accgacgcga ctcagcaaca acttgcacaa     2280

ggccctgttg ctggaacacc aaatgttttc tcttcagatg taccatcagt tgcgttgctt     2340

ctgtttccta atgggacagt catacacttg ctcgctttcg atacccttcc tattgcaact     2400

attgcaccgg gcttcctcgc agcaagcgct ttgggcgtgg taatgatcac agcagcactt     2460

gctgggatac tccgcgtcgt gcgtacatgt gtgcctttcc tgtggcgtag ggagtag        2517


<210>  542
<211>  838
<212>  PRT
<213>  Simplexvirus Herpes simplex virus type 2

<400>  542

Met Gly Pro Gly Leu Trp Val Val Met Gly Val Leu Val Gly Val Ala 
1               5                   10                  15      


Gly Gly His Asp Thr Tyr Trp Thr Glu Gln Ile Asp Pro Trp Phe Leu 
            20                  25                  30          


His Gly Leu Gly Leu Ala Arg Thr Tyr Trp Arg Asp Thr Asn Thr Gly 
        35                  40                  45              


Arg Leu Trp Leu Pro Asn Thr Pro Asp Ala Ser Asp Pro Gln Arg Gly 
    50                  55                  60                  


Arg Leu Ala Pro Pro Gly Glu Leu Asn Leu Thr Thr Ala Ser Val Pro 
65                  70                  75                  80  


Met Leu Arg Trp Tyr Ala Glu Arg Phe Cys Phe Val Leu Val Thr Thr 
                85                  90                  95      


Ala Glu Phe Pro Arg Asp Pro Gly Gln Leu Leu Tyr Ile Pro Lys Thr 
            100                 105                 110         


Tyr Leu Leu Gly Arg Pro Arg Asn Ala Ser Leu Pro Glu Leu Pro Glu 
        115                 120                 125             


Ala Gly Pro Thr Ser Arg Pro Pro Ala Glu Val Thr Gln Leu Lys Gly 
    130                 135                 140                 


Leu Ser His Asn Pro Gly Ala Ser Ala Leu Leu Arg Ser Arg Ala Trp 
145                 150                 155                 160 


Val Thr Phe Ala Ala Ala Pro Asp Arg Glu Gly Leu Thr Phe Pro Arg 
                165                 170                 175     


Gly Asp Asp Gly Ala Thr Glu Arg His Pro Asp Gly Arg Arg Asn Ala 
            180                 185                 190         


Pro Pro Pro Gly Pro Pro Ala Gly Thr Pro Arg His Pro Thr Thr Asn 
        195                 200                 205             


Leu Ser Ile Ala His Leu His Asn Ala Ser Val Thr Trp Leu Ala Ala 
    210                 215                 220                 


Arg Gly Leu Leu Arg Thr Pro Gly Arg Tyr Val Tyr Leu Ser Pro Ser 
225                 230                 235                 240 


Ala Ser Thr Trp Pro Val Gly Val Trp Thr Thr Gly Gly Leu Ala Phe 
                245                 250                 255     


Gly Cys Asp Ala Ala Leu Val Arg Ala Arg Tyr Gly Lys Gly Phe Met 
            260                 265                 270         


Gly Leu Val Ile Ser Met Arg Asp Ser Pro Pro Ala Glu Ile Ile Val 
        275                 280                 285             


Val Pro Ala Asp Lys Thr Leu Ala Arg Val Gly Asn Pro Thr Asp Glu 
    290                 295                 300                 


Asn Ala Pro Ala Val Leu Pro Gly Pro Pro Ala Gly Pro Arg Tyr Arg 
305                 310                 315                 320 


Val Phe Val Leu Gly Ala Pro Thr Pro Ala Asp Asn Gly Ser Ala Leu 
                325                 330                 335     


Asp Ala Leu Arg Arg Val Ala Gly Tyr Pro Glu Glu Ser Thr Asn Tyr 
            340                 345                 350         


Ala Gln Tyr Met Ser Arg Ala Tyr Ala Glu Phe Leu Gly Glu Asp Pro 
        355                 360                 365             


Gly Ser Gly Thr Asp Ala Arg Pro Ser Leu Phe Trp Arg Leu Ala Gly 
    370                 375                 380                 


Leu Leu Ala Ser Ser Gly Phe Ala Phe Val Asn Ala Ala His Ala His 
385                 390                 395                 400 


Asp Ala Ile Arg Leu Ser Asp Leu Leu Gly Phe Leu Ala His Ser Arg 
                405                 410                 415     


Val Leu Ala Gly Leu Ala Ala Arg Gly Ala Ala Gly Cys Ala Ala Asp 
            420                 425                 430         


Ser Val Phe Leu Asn Val Ser Val Leu Asp Pro Ala Ala Arg Leu Arg 
        435                 440                 445             


Leu Glu Ala Arg Leu Gly His Leu Val Ala Ala Ile Leu Glu Arg Glu 
    450                 455                 460                 


Gln Ser Leu Val Ala His Ala Leu Gly Tyr Gln Leu Ala Phe Val Leu 
465                 470                 475                 480 


Asp Ser Pro Ala Ala Tyr Gly Ala Val Ala Pro Ser Ala Ala Arg Leu 
                485                 490                 495     


Ile Asp Ala Leu Tyr Ala Glu Phe Leu Gly Gly Arg Ala Leu Thr Ala 
            500                 505                 510         


Pro Met Val Arg Arg Ala Leu Phe Tyr Ala Thr Ala Val Leu Arg Ala 
        515                 520                 525             


Pro Phe Leu Ala Gly Ala Pro Ser Ala Glu Gln Arg Glu Arg Ala Arg 
    530                 535                 540                 


Arg Gly Leu Leu Ile Thr Thr Ala Leu Cys Thr Ser Asp Val Ala Ala 
545                 550                 555                 560 


Ala Thr His Ala Asp Leu Arg Ala Ala Leu Ala Arg Thr Asp His Gln 
                565                 570                 575     


Lys Asn Leu Phe Trp Leu Pro Asp His Phe Ser Pro Cys Ala Ala Ser 
            580                 585                 590         


Leu Arg Phe Asp Leu Ala Glu Gly Gly Phe Ile Leu Asp Ala Leu Ala 
        595                 600                 605             


Met Ala Thr Arg Ser Asp Ile Pro Ala Asp Val Met Ala Gln Gln Thr 
    610                 615                 620                 


Arg Gly Val Ala Ser Val Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
625                 630                 635                 640 


Ile Arg Ala Phe Val Pro Glu Ala Thr His Gln Cys Ser Gly Pro Ser 
                645                 650                 655     


His Asn Ala Glu Pro Arg Ile Leu Val Pro Ile Thr His Asn Ala Ser 
            660                 665                 670         


Tyr Val Val Thr His Thr Pro Leu Pro Arg Gly Ile Gly Tyr Lys Leu 
        675                 680                 685             


Thr Gly Val Asp Val Arg Arg Pro Leu Phe Ile Thr Tyr Leu Thr Ala 
    690                 695                 700                 


Thr Cys Glu Gly His Ala Arg Glu Ile Glu Pro Lys Arg Leu Val Arg 
705                 710                 715                 720 


Thr Glu Asn Arg Arg Asp Leu Gly Leu Val Gly Ala Val Phe Leu Arg 
                725                 730                 735     


Tyr Thr Pro Ala Gly Glu Val Met Ser Val Leu Leu Val Asp Thr Asp 
            740                 745                 750         


Ala Thr Gln Gln Gln Leu Ala Gln Gly Pro Val Ala Gly Thr Pro Asn 
        755                 760                 765             


Val Phe Ser Ser Asp Val Pro Ser Val Ala Leu Leu Leu Phe Pro Asn 
    770                 775                 780                 


Gly Thr Val Ile His Leu Leu Ala Phe Asp Thr Leu Pro Ile Ala Thr 
785                 790                 795                 800 


Ile Ala Pro Gly Phe Leu Ala Ala Ser Ala Leu Gly Val Val Met Ile 
                805                 810                 815     


Thr Ala Ala Leu Ala Gly Ile Leu Arg Val Val Arg Thr Cys Val Pro 
            820                 825                 830         


Phe Leu Trp Arg Arg Glu 
        835             


<210>  543
<211>  675
<212>  DNA
<213>  Simplexvirus Herpes simplex virus type 2

<400>  543
atggggttcg tctgtctgtt tgggcttgtc gttatgggag cctggggggc gtggggtggg       60

tcacaggcaa ccgaatatgt tcttcgtagt gttattgcca aagaggtggg ggacatacta      120

agagtgcctt gcatgcggac ccccgcggac gatgtttctt ggcgctacga ggccccgtcc      180

gttattgact atgcccgcat agacggaata tttcttcgct atcactgccc ggggttggac      240

acgtttttgt gggataggca cgcccagagg gcgtatctgg ttaacccctt tctctttgcg      300

gcgggatttt tggaggactt gagtcactct gtgtttccgg ccgacaccca ggaaacaacg      360

acgcgccggg ccctttataa agagatacgc gatgcgttgg gcagtcgaaa acaggccgtc      420

agccacgcac ccgtcagggc cgggtgtgta aactttgact actcacgcac tcgccgctgc      480

gtcgggcgac gcgatttacg gcctgccaac accacgtcaa cgtgggaacc gcctgtgtcg      540

tcggacgatg aagcgagctc gcagtcgaag cccctcgcca cccagccgcc cgtcctcgcc      600

ctttcgaacg cccccccacg gcgggtctcc ccgacgcgag gtcggcgccg gcatactcgc      660

ctccgacgca actag                                                       675


<210>  544
<211>  224
<212>  PRT
<213>  Simplexvirus Herpes simplex virus type 2

<400>  544

Met Gly Phe Val Cys Leu Phe Gly Leu Val Val Met Gly Ala Trp Gly 
1               5                   10                  15      


Ala Trp Gly Gly Ser Gln Ala Thr Glu Tyr Val Leu Arg Ser Val Ile 
            20                  25                  30          


Ala Lys Glu Val Gly Asp Ile Leu Arg Val Pro Cys Met Arg Thr Pro 
        35                  40                  45              


Ala Asp Asp Val Ser Trp Arg Tyr Glu Ala Pro Ser Val Ile Asp Tyr 
    50                  55                  60                  


Ala Arg Ile Asp Gly Ile Phe Leu Arg Tyr His Cys Pro Gly Leu Asp 
65                  70                  75                  80  


Thr Phe Leu Trp Asp Arg His Ala Gln Arg Ala Tyr Leu Val Asn Pro 
                85                  90                  95      


Phe Leu Phe Ala Ala Gly Phe Leu Glu Asp Leu Ser His Ser Val Phe 
            100                 105                 110         


Pro Ala Asp Thr Gln Glu Thr Thr Thr Arg Arg Ala Leu Tyr Lys Glu 
        115                 120                 125             


Ile Arg Asp Ala Leu Gly Ser Arg Lys Gln Ala Val Ser His Ala Pro 
    130                 135                 140                 


Val Arg Ala Gly Cys Val Asn Phe Asp Tyr Ser Arg Thr Arg Arg Cys 
145                 150                 155                 160 


Val Gly Arg Arg Asp Leu Arg Pro Ala Asn Thr Thr Ser Thr Trp Glu 
                165                 170                 175     


Pro Pro Val Ser Ser Asp Asp Glu Ala Ser Ser Gln Ser Lys Pro Leu 
            180                 185                 190         


Ala Thr Gln Pro Pro Val Leu Ala Leu Ser Asn Ala Pro Pro Arg Arg 
        195                 200                 205             


Val Ser Pro Thr Arg Gly Arg Arg Arg His Thr Arg Leu Arg Arg Asn 
    210                 215                 220                 


<210>  545
<211>  2607
<212>  DNA
<213>  Varicellovirus Varicella virus

<400>  545
atgtttgtta cggcggttgt gtcggtctct ccaagctcgt tttatgagag tttacaagta       60

gagcccacac aatcagaaga tataacccgg tctgctcatc tgggcgatgg tgatgaaatc      120

agagaagcta tacacaagtc ccaggacgcc gaaacaaaac ccacgtttta cgtctgccca      180

ccgccaacag gctccacaat cgtacgatta gaaccaactc ggacatgtcc ggattatcac      240

cttggtaaaa actttacaga gggtattgct gttgtttata aagaaaacat tgcagcgtac      300

aagtttaagg cgacggtata ttacaaagat gttatcgtta gcacggcgtg ggccggaagt      360

tcttatacgc aaattactaa tagatatgcg gatagggtac caattcccgt ttcagagatc      420

acggacacca ttgataagtt tggcaagtgt tcttctaaag caacgtacgt acgaaataac      480

cacaaagttg aagcctttaa tgaggataaa aatccacagg atatgcctct aatcgcatca      540

aaatataatt ctgtgggatc caaagcatgg catactacca atgacacgta catggttgcc      600

ggaacccccg gaacatatag gacgggcacg tcggtgaatt gcatcattga ggaagttgaa      660

gccagatcaa tattccctta tgatagtttt ggactttcca cgggagatat aatatacatg      720

tccccgtttt ttggcctacg ggatggtgca tacagagaac attccaatta tgcaatggat      780

cgttttcacc agtttgaggg ttatagacaa agggatcttg acactagagc attactggaa      840

cctgcagcgc ggaacttttt agtcacgcct catttaacgg ttggttggaa ctggaagcca      900

aaacgaacgg aagtttgttc gcttgtcaag tggcgtgagg ttgaagacgt agttcgcgat      960

gagtatgcac acaattttcg ctttacaatg aaaacacttt ctaccacgtt tataagtgaa     1020

acaaacgagt ttaatcttaa ccaaatccat ctcagtcaat gtgtaaagga ggaagcccgg     1080

gctattatta accggatcta tacaaccaga tacaactcat ctcatgttag aaccggggat     1140

atccagacct accttgccag aggggggttt gttgtggtgt ttcaacccct gctgagcaat     1200

tccctcgccc gtctctatct ccaagaattg gtccgtgaaa acactaatca ttcaccacaa     1260

aaacacccga ctcgaaatac cagatcccga cgaagcgtgc cagttgagtt gcgtgccaat     1320

agaacaataa caaccacctc atcggtggaa tttgctatgc tccagtttac atatgaccac     1380

attcaagagc atgttaatga aatgttggca cgtatctcct cgtcgtggtg ccagctacaa     1440

aatcgcgaac gcgccctttg gagcggacta tttccaatta acccaagtgc tttagcgagc     1500

accattttgg atcaacgtgt taaagctcgt attctcggcg acgttatctc cgtttctaat     1560

tgtccagaac tgggatcaga tacacgcatt atacttcaaa actctatgag ggtatctggt     1620

agtactacgc gttgttatag ccgtccttta atttcaatag ttagtttaaa tgggtccggg     1680

acggtggagg gccagcttgg aacagataac gagttaatta tgtccagaga tctgttagaa     1740

ccatgcgtgg ctaatcacaa gcgatatttt ctatttgggc atcactacgt atattatgag     1800

gattatcgtt acgtccgtga aatcgcagtc catgatgtgg gaatgattag cacttacgta     1860

gatttaaact taacacttct taaagataga gagtttatgc cgctgcaagt atatacaaga     1920

gacgagctgc gggatacagg attactagac tacagtgaaa ttcaacgccg aaatcaaatg     1980

cattcgctgc gtttttatga catagacaag gttgtgcaat atgatagcgg aacggccatt     2040

atgcagggca tggctcagtt tttccaggga cttgggaccg cgggccaggc cgttggacat     2100

gtggttcttg gggccacggg agcgctgctt tccaccgtac acggatttac cacgttttta     2160

tctaacccat ttggggcatt ggccgtggga ttattggttt tggcgggact ggtagcggcc     2220

ttttttgcgt accggtacgt gcttaaactt aaaacaagcc cgatgaaggc attatatcca     2280

ctcacaacca aggggttaaa acagttaccg gaaggaatgg atccctttgc cgagaaaccc     2340

aacgctactg ataccccaat agaagaaatt ggcgactcac aaaacactga accgtcggta     2400

aatagcgggt ttgatcccga taaatttcga gaagcccagg aaatgattaa atatatgacg     2460

ttagtatctg cggctgagcg ccaagaatct aaagcccgca aaaaaaataa gactagcgcc     2520

cttttaactt cacgtcttac cggccttgct ttacgaaatc gccgaggata ctcccgtgtt     2580

cgcaccgaga atgtaacggg ggtgtaa                                         2607


<210>  546
<211>  868
<212>  PRT
<213>  Varicellovirus Varicella virus

<400>  546

Met Phe Val Thr Ala Val Val Ser Val Ser Pro Ser Ser Phe Tyr Glu 
1               5                   10                  15      


Ser Leu Gln Val Glu Pro Thr Gln Ser Glu Asp Ile Thr Arg Ser Ala 
            20                  25                  30          


His Leu Gly Asp Gly Asp Glu Ile Arg Glu Ala Ile His Lys Ser Gln 
        35                  40                  45              


Asp Ala Glu Thr Lys Pro Thr Phe Tyr Val Cys Pro Pro Pro Thr Gly 
    50                  55                  60                  


Ser Thr Ile Val Arg Leu Glu Pro Thr Arg Thr Cys Pro Asp Tyr His 
65                  70                  75                  80  


Leu Gly Lys Asn Phe Thr Glu Gly Ile Ala Val Val Tyr Lys Glu Asn 
                85                  90                  95      


Ile Ala Ala Tyr Lys Phe Lys Ala Thr Val Tyr Tyr Lys Asp Val Ile 
            100                 105                 110         


Val Ser Thr Ala Trp Ala Gly Ser Ser Tyr Thr Gln Ile Thr Asn Arg 
        115                 120                 125             


Tyr Ala Asp Arg Val Pro Ile Pro Val Ser Glu Ile Thr Asp Thr Ile 
    130                 135                 140                 


Asp Lys Phe Gly Lys Cys Ser Ser Lys Ala Thr Tyr Val Arg Asn Asn 
145                 150                 155                 160 


His Lys Val Glu Ala Phe Asn Glu Asp Lys Asn Pro Gln Asp Met Pro 
                165                 170                 175     


Leu Ile Ala Ser Lys Tyr Asn Ser Val Gly Ser Lys Ala Trp His Thr 
            180                 185                 190         


Thr Asn Asp Thr Tyr Met Val Ala Gly Thr Pro Gly Thr Tyr Arg Thr 
        195                 200                 205             


Gly Thr Ser Val Asn Cys Ile Ile Glu Glu Val Glu Ala Arg Ser Ile 
    210                 215                 220                 


Phe Pro Tyr Asp Ser Phe Gly Leu Ser Thr Gly Asp Ile Ile Tyr Met 
225                 230                 235                 240 


Ser Pro Phe Phe Gly Leu Arg Asp Gly Ala Tyr Arg Glu His Ser Asn 
                245                 250                 255     


Tyr Ala Met Asp Arg Phe His Gln Phe Glu Gly Tyr Arg Gln Arg Asp 
            260                 265                 270         


Leu Asp Thr Arg Ala Leu Leu Glu Pro Ala Ala Arg Asn Phe Leu Val 
        275                 280                 285             


Thr Pro His Leu Thr Val Gly Trp Asn Trp Lys Pro Lys Arg Thr Glu 
    290                 295                 300                 


Val Cys Ser Leu Val Lys Trp Arg Glu Val Glu Asp Val Val Arg Asp 
305                 310                 315                 320 


Glu Tyr Ala His Asn Phe Arg Phe Thr Met Lys Thr Leu Ser Thr Thr 
                325                 330                 335     


Phe Ile Ser Glu Thr Asn Glu Phe Asn Leu Asn Gln Ile His Leu Ser 
            340                 345                 350         


Gln Cys Val Lys Glu Glu Ala Arg Ala Ile Ile Asn Arg Ile Tyr Thr 
        355                 360                 365             


Thr Arg Tyr Asn Ser Ser His Val Arg Thr Gly Asp Ile Gln Thr Tyr 
    370                 375                 380                 


Leu Ala Arg Gly Gly Phe Val Val Val Phe Gln Pro Leu Leu Ser Asn 
385                 390                 395                 400 


Ser Leu Ala Arg Leu Tyr Leu Gln Glu Leu Val Arg Glu Asn Thr Asn 
                405                 410                 415     


His Ser Pro Gln Lys His Pro Thr Arg Asn Thr Arg Ser Arg Arg Ser 
            420                 425                 430         


Val Pro Val Glu Leu Arg Ala Asn Arg Thr Ile Thr Thr Thr Ser Ser 
        435                 440                 445             


Val Glu Phe Ala Met Leu Gln Phe Thr Tyr Asp His Ile Gln Glu His 
    450                 455                 460                 


Val Asn Glu Met Leu Ala Arg Ile Ser Ser Ser Trp Cys Gln Leu Gln 
465                 470                 475                 480 


Asn Arg Glu Arg Ala Leu Trp Ser Gly Leu Phe Pro Ile Asn Pro Ser 
                485                 490                 495     


Ala Leu Ala Ser Thr Ile Leu Asp Gln Arg Val Lys Ala Arg Ile Leu 
            500                 505                 510         


Gly Asp Val Ile Ser Val Ser Asn Cys Pro Glu Leu Gly Ser Asp Thr 
        515                 520                 525             


Arg Ile Ile Leu Gln Asn Ser Met Arg Val Ser Gly Ser Thr Thr Arg 
    530                 535                 540                 


Cys Tyr Ser Arg Pro Leu Ile Ser Ile Val Ser Leu Asn Gly Ser Gly 
545                 550                 555                 560 


Thr Val Glu Gly Gln Leu Gly Thr Asp Asn Glu Leu Ile Met Ser Arg 
                565                 570                 575     


Asp Leu Leu Glu Pro Cys Val Ala Asn His Lys Arg Tyr Phe Leu Phe 
            580                 585                 590         


Gly His His Tyr Val Tyr Tyr Glu Asp Tyr Arg Tyr Val Arg Glu Ile 
        595                 600                 605             


Ala Val His Asp Val Gly Met Ile Ser Thr Tyr Val Asp Leu Asn Leu 
    610                 615                 620                 


Thr Leu Leu Lys Asp Arg Glu Phe Met Pro Leu Gln Val Tyr Thr Arg 
625                 630                 635                 640 


Asp Glu Leu Arg Asp Thr Gly Leu Leu Asp Tyr Ser Glu Ile Gln Arg 
                645                 650                 655     


Arg Asn Gln Met His Ser Leu Arg Phe Tyr Asp Ile Asp Lys Val Val 
            660                 665                 670         


Gln Tyr Asp Ser Gly Thr Ala Ile Met Gln Gly Met Ala Gln Phe Phe 
        675                 680                 685             


Gln Gly Leu Gly Thr Ala Gly Gln Ala Val Gly His Val Val Leu Gly 
    690                 695                 700                 


Ala Thr Gly Ala Leu Leu Ser Thr Val His Gly Phe Thr Thr Phe Leu 
705                 710                 715                 720 


Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val Leu Ala Gly 
                725                 730                 735     


Leu Val Ala Ala Phe Phe Ala Tyr Arg Tyr Val Leu Lys Leu Lys Thr 
            740                 745                 750         


Ser Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Gly Leu Lys Gln 
        755                 760                 765             


Leu Pro Glu Gly Met Asp Pro Phe Ala Glu Lys Pro Asn Ala Thr Asp 
    770                 775                 780                 


Thr Pro Ile Glu Glu Ile Gly Asp Ser Gln Asn Thr Glu Pro Ser Val 
785                 790                 795                 800 


Asn Ser Gly Phe Asp Pro Asp Lys Phe Arg Glu Ala Gln Glu Met Ile 
                805                 810                 815     


Lys Tyr Met Thr Leu Val Ser Ala Ala Glu Arg Gln Glu Ser Lys Ala 
            820                 825                 830         


Arg Lys Lys Asn Lys Thr Ser Ala Leu Leu Thr Ser Arg Leu Thr Gly 
        835                 840                 845             


Leu Ala Leu Arg Asn Arg Arg Gly Tyr Ser Arg Val Arg Thr Glu Asn 
    850                 855                 860                 


Val Thr Gly Val 
865             


<210>  547
<211>  1023
<212>  DNA
<213>  Varicellovirus Varicella virus

<400>  547
atgcaggctt taggaatcaa gacagaacat tttataatta tgtgtctact tagcggacat       60

gctgttttta ccctatggta taccgctcgt gtaaagtttg aacatgagtg tgtgtatgca      120

accacggtga ttaatggtgg accggttgta tgggggtctt ataacaactc tcttatatat      180

gtaacgtttg taaaccactc aacgtttttg gatggcctat ctggatacga ttacagctgc      240

cgggaaaatc tattatcagg agatactatg gtaaaaaccg ctatttctac acctttgcat      300

gacaaaattc gaattgttct gggaacacgt aattgtcacg cttatttttg gtgcgtgcag      360

ctaaaaatga ttttttttgc atggtttgta tatggtatgt atttacaatt tcgacgaata      420

cgtcgtatgt ttgggccatt ccgatcatcc tgtgagttaa tatcccccac atcatattca      480

ctgaattacg taacacgggt tatttcgaac attcttcttg gttacccata tacaaagttg      540

gcaaggttgt tatgtgatgt ttccatgcga cgggatggta tgagtaaagt atttaatgct      600

gaccctataa gttttttata tatgcataaa ggtgttacgt tattgatgct tttggaggtt      660

atcgctcata tatcatctgg atgtattgtg cttttaacgc ttggcgttgc atatacacca      720

tgcgcgttat tataccccac atacattcgg attctggcct gggttgttgt atgcacgctc      780

gctatagtag agcttatatc ttatgttaga ccaaaaccaa ccaaggataa tcatttaaat      840

catatcaata cggggggaat acgtggtata tgcacaacat gttgcgctac agtaatgtcc      900

ggccttgcta taaaatgttt ttatatcgtc atatttgcta tagcagtggt tatttttatg      960

cattacgaac aaagggtgca ggtaagcttg tttggggaaa gtgaaaactc ccagaagcat     1020

taa                                                                   1023


<210>  548
<211>  340
<212>  PRT
<213>  Varicellovirus Varicella virus

<400>  548

Met Gln Ala Leu Gly Ile Lys Thr Glu His Phe Ile Ile Met Cys Leu 
1               5                   10                  15      


Leu Ser Gly His Ala Val Phe Thr Leu Trp Tyr Thr Ala Arg Val Lys 
            20                  25                  30          


Phe Glu His Glu Cys Val Tyr Ala Thr Thr Val Ile Asn Gly Gly Pro 
        35                  40                  45              


Val Val Trp Gly Ser Tyr Asn Asn Ser Leu Ile Tyr Val Thr Phe Val 
    50                  55                  60                  


Asn His Ser Thr Phe Leu Asp Gly Leu Ser Gly Tyr Asp Tyr Ser Cys 
65                  70                  75                  80  


Arg Glu Asn Leu Leu Ser Gly Asp Thr Met Val Lys Thr Ala Ile Ser 
                85                  90                  95      


Thr Pro Leu His Asp Lys Ile Arg Ile Val Leu Gly Thr Arg Asn Cys 
            100                 105                 110         


His Ala Tyr Phe Trp Cys Val Gln Leu Lys Met Ile Phe Phe Ala Trp 
        115                 120                 125             


Phe Val Tyr Gly Met Tyr Leu Gln Phe Arg Arg Ile Arg Arg Met Phe 
    130                 135                 140                 


Gly Pro Phe Arg Ser Ser Cys Glu Leu Ile Ser Pro Thr Ser Tyr Ser 
145                 150                 155                 160 


Leu Asn Tyr Val Thr Arg Val Ile Ser Asn Ile Leu Leu Gly Tyr Pro 
                165                 170                 175     


Tyr Thr Lys Leu Ala Arg Leu Leu Cys Asp Val Ser Met Arg Arg Asp 
            180                 185                 190         


Gly Met Ser Lys Val Phe Asn Ala Asp Pro Ile Ser Phe Leu Tyr Met 
        195                 200                 205             


His Lys Gly Val Thr Leu Leu Met Leu Leu Glu Val Ile Ala His Ile 
    210                 215                 220                 


Ser Ser Gly Cys Ile Val Leu Leu Thr Leu Gly Val Ala Tyr Thr Pro 
225                 230                 235                 240 


Cys Ala Leu Leu Tyr Pro Thr Tyr Ile Arg Ile Leu Ala Trp Val Val 
                245                 250                 255     


Val Cys Thr Leu Ala Ile Val Glu Leu Ile Ser Tyr Val Arg Pro Lys 
            260                 265                 270         


Pro Thr Lys Asp Asn His Leu Asn His Ile Asn Thr Gly Gly Ile Arg 
        275                 280                 285             


Gly Ile Cys Thr Thr Cys Cys Ala Thr Val Met Ser Gly Leu Ala Ile 
    290                 295                 300                 


Lys Cys Phe Tyr Ile Val Ile Phe Ala Ile Ala Val Val Ile Phe Met 
305                 310                 315                 320 


His Tyr Glu Gln Arg Val Gln Val Ser Leu Phe Gly Glu Ser Glu Asn 
                325                 330                 335     


Ser Gln Lys His 
            340 


<210>  549
<211>  2526
<212>  DNA
<213>  Varicellovirus Varicella virus

<400>  549
atgtttgcgc tagttttagc ggtggtaatt cttcctcttt ggaccacggc taataaatct       60

tacgtaacac caacccctgc gactcgctct atcggacata tgtctgctct tctacgagaa      120

tattccgacc gtaatatgtc tctgaaatta gaagcctttt atcctactgg tttcgatgaa      180

gaactcatta aatcacttca ctggggaaat gatagaaaac acgttttctt ggttattgtt      240

aaggttaacc ctacaacaca cgaaggagac gtcgggctgg ttatatttcc aaaatacttg      300

ttatcgccat accatttcaa agcagaacat cgagcaccgt ttcctgctgg acgttttgga      360

tttcttagtc accctgtgac acccgacgtg agcttctttg acagttcgtt tgcgccgtat      420

ttaactacgc aacatcttgt tgcgtttact acgttcccac caaaccccct tgtatggcat      480

ttggaaagag ctgagaccgc agcaactgca gaaaggccgt ttggggtaag tcttttaccc      540

gctcgcccaa cagtccccaa gaatactatt ctggaacata aagcgcattt tgctacatgg      600

gatgcccttg cccgacatac ttttttttct gccgaagcaa ttatcaccaa ctcaacgttg      660

agaatacacg ttcccctttt tgggtcggta tggccaattc gatactgggc caccggttcg      720

gtgcttctca caagcgactc gggtcgtgtg gaagtaaata ttggtgtagg atttatgagc      780

tcgctcattt ctttatcctc tggaccaccg atagaattaa ttgttgtacc acatacagta      840

aaactgaacg cggttacaag cgacaccaca tggttccagc taaatccacc gggtccggat      900

ccggggccat cttatcgagt ttatttactt ggacgtgggt tggatatgaa tttttcaaag      960

catgctacgg tcgatatatg cgcatatccc gaagagagtt tggattaccg ctatcattta     1020

tccatggccc acacggaggc tctgcggatg acaacgaagg cggatcaaca tgacataaac     1080

gaggaaagct attaccatat cgccgcaaga atagccacat caatttttgc gttgtcggaa     1140

atgggccgta ccacagaata ttttctgtta gatgagatcg tagatgttca gtatcaatta     1200

aaattcctta attacatttt aatgcggata ggagcaggag ctcatcccaa cactatatcc     1260

ggaacctcgg atctgatctt tgccgatcca tcgcagcttc atgacgaact ttcacttctt     1320

tttggtcagg taaaacccgc aaatgtcgat tattttattt catatgatga agcccgtgat     1380

caactaaaga ccgcatacgc gctttcccgt ggtcaagacc atgtgaatgc actttctctc     1440

gccaggcgtg ttataatgag catatacaag gggctgcttg tgaagcaaaa tttaaatgct     1500

acagagaggc aggctttatt ttttgcctca atgattttat taaatttccg cgaaggacta     1560

gaaaattcat ctcgggtatt agacggtcgc acaactttgc ttttaatgac atccatgtgt     1620

acggcagctc acgccacgca agcagcactt aacatacaag aaggcctggc atacttaaat     1680

ccttcaaaac acatgtttac aataccaaac gtatacagtc cttgtatggg ttcccttcgt     1740

acagacctca cggaagagat tcatgttatg aatctcctgt cggcaatacc aacacgccca     1800

ggacttaacg aggtattgca tacccaacta gacgaatctg aaatattcga cgcggcattt     1860

aaaaccatga tgatttttac cacatggact gccaaagatt tgcatatact ccacacccat     1920

gtaccagaag tatttacgtg tcaagatgca gccgcgcgta acggagaata tgtgctcatt     1980

cttccagctg tccagggaca cagttatgtg attacacgaa acaaacctca aaggggtttg     2040

gtatattccc tggcagatgt ggatgtatat aaccccatat ccgttgttta tttaagcagg     2100

gatacttgcg tgtctgaaca tggtgtcata gagacggtcg cactgcccca tccggacaat     2160

ttaaaagaat gtttgtattg cggaagtgtt tttcttaggt atctaaccac gggggcgatt     2220

atggatataa ttattattga cagcaaagat acagaacgac aactagccgc tatgggaaac     2280

tccacaattc cacccttcaa tccagacatg cacggggatg actctaaggc tgtgttgttg     2340

tttccaaacg gaactgtggt aacgcttcta ggattcgaac gacgacaagc catacgaatg     2400

tcgggacaat accttggggc ctctttagga ggggcgtttc tggcggtagt ggggtttggt     2460

attatcggat ggatgttatg tggaaattcc cgccttcgag aatataataa aatacctctg     2520

acataa                                                                2526


<210>  550
<211>  841
<212>  PRT
<213>  Varicellovirus Varicella virus

<400>  550

Met Phe Ala Leu Val Leu Ala Val Val Ile Leu Pro Leu Trp Thr Thr 
1               5                   10                  15      


Ala Asn Lys Ser Tyr Val Thr Pro Thr Pro Ala Thr Arg Ser Ile Gly 
            20                  25                  30          


His Met Ser Ala Leu Leu Arg Glu Tyr Ser Asp Arg Asn Met Ser Leu 
        35                  40                  45              


Lys Leu Glu Ala Phe Tyr Pro Thr Gly Phe Asp Glu Glu Leu Ile Lys 
    50                  55                  60                  


Ser Leu His Trp Gly Asn Asp Arg Lys His Val Phe Leu Val Ile Val 
65                  70                  75                  80  


Lys Val Asn Pro Thr Thr His Glu Gly Asp Val Gly Leu Val Ile Phe 
                85                  90                  95      


Pro Lys Tyr Leu Leu Ser Pro Tyr His Phe Lys Ala Glu His Arg Ala 
            100                 105                 110         


Pro Phe Pro Ala Gly Arg Phe Gly Phe Leu Ser His Pro Val Thr Pro 
        115                 120                 125             


Asp Val Ser Phe Phe Asp Ser Ser Phe Ala Pro Tyr Leu Thr Thr Gln 
    130                 135                 140                 


His Leu Val Ala Phe Thr Thr Phe Pro Pro Asn Pro Leu Val Trp His 
145                 150                 155                 160 


Leu Glu Arg Ala Glu Thr Ala Ala Thr Ala Glu Arg Pro Phe Gly Val 
                165                 170                 175     


Ser Leu Leu Pro Ala Arg Pro Thr Val Pro Lys Asn Thr Ile Leu Glu 
            180                 185                 190         


His Lys Ala His Phe Ala Thr Trp Asp Ala Leu Ala Arg His Thr Phe 
        195                 200                 205             


Phe Ser Ala Glu Ala Ile Ile Thr Asn Ser Thr Leu Arg Ile His Val 
    210                 215                 220                 


Pro Leu Phe Gly Ser Val Trp Pro Ile Arg Tyr Trp Ala Thr Gly Ser 
225                 230                 235                 240 


Val Leu Leu Thr Ser Asp Ser Gly Arg Val Glu Val Asn Ile Gly Val 
                245                 250                 255     


Gly Phe Met Ser Ser Leu Ile Ser Leu Ser Ser Gly Pro Pro Ile Glu 
            260                 265                 270         


Leu Ile Val Val Pro His Thr Val Lys Leu Asn Ala Val Thr Ser Asp 
        275                 280                 285             


Thr Thr Trp Phe Gln Leu Asn Pro Pro Gly Pro Asp Pro Gly Pro Ser 
    290                 295                 300                 


Tyr Arg Val Tyr Leu Leu Gly Arg Gly Leu Asp Met Asn Phe Ser Lys 
305                 310                 315                 320 


His Ala Thr Val Asp Ile Cys Ala Tyr Pro Glu Glu Ser Leu Asp Tyr 
                325                 330                 335     


Arg Tyr His Leu Ser Met Ala His Thr Glu Ala Leu Arg Met Thr Thr 
            340                 345                 350         


Lys Ala Asp Gln His Asp Ile Asn Glu Glu Ser Tyr Tyr His Ile Ala 
        355                 360                 365             


Ala Arg Ile Ala Thr Ser Ile Phe Ala Leu Ser Glu Met Gly Arg Thr 
    370                 375                 380                 


Thr Glu Tyr Phe Leu Leu Asp Glu Ile Val Asp Val Gln Tyr Gln Leu 
385                 390                 395                 400 


Lys Phe Leu Asn Tyr Ile Leu Met Arg Ile Gly Ala Gly Ala His Pro 
                405                 410                 415     


Asn Thr Ile Ser Gly Thr Ser Asp Leu Ile Phe Ala Asp Pro Ser Gln 
            420                 425                 430         


Leu His Asp Glu Leu Ser Leu Leu Phe Gly Gln Val Lys Pro Ala Asn 
        435                 440                 445             


Val Asp Tyr Phe Ile Ser Tyr Asp Glu Ala Arg Asp Gln Leu Lys Thr 
    450                 455                 460                 


Ala Tyr Ala Leu Ser Arg Gly Gln Asp His Val Asn Ala Leu Ser Leu 
465                 470                 475                 480 


Ala Arg Arg Val Ile Met Ser Ile Tyr Lys Gly Leu Leu Val Lys Gln 
                485                 490                 495     


Asn Leu Asn Ala Thr Glu Arg Gln Ala Leu Phe Phe Ala Ser Met Ile 
            500                 505                 510         


Leu Leu Asn Phe Arg Glu Gly Leu Glu Asn Ser Ser Arg Val Leu Asp 
        515                 520                 525             


Gly Arg Thr Thr Leu Leu Leu Met Thr Ser Met Cys Thr Ala Ala His 
    530                 535                 540                 


Ala Thr Gln Ala Ala Leu Asn Ile Gln Glu Gly Leu Ala Tyr Leu Asn 
545                 550                 555                 560 


Pro Ser Lys His Met Phe Thr Ile Pro Asn Val Tyr Ser Pro Cys Met 
                565                 570                 575     


Gly Ser Leu Arg Thr Asp Leu Thr Glu Glu Ile His Val Met Asn Leu 
            580                 585                 590         


Leu Ser Ala Ile Pro Thr Arg Pro Gly Leu Asn Glu Val Leu His Thr 
        595                 600                 605             


Gln Leu Asp Glu Ser Glu Ile Phe Asp Ala Ala Phe Lys Thr Met Met 
    610                 615                 620                 


Ile Phe Thr Thr Trp Thr Ala Lys Asp Leu His Ile Leu His Thr His 
625                 630                 635                 640 


Val Pro Glu Val Phe Thr Cys Gln Asp Ala Ala Ala Arg Asn Gly Glu 
                645                 650                 655     


Tyr Val Leu Ile Leu Pro Ala Val Gln Gly His Ser Tyr Val Ile Thr 
            660                 665                 670         


Arg Asn Lys Pro Gln Arg Gly Leu Val Tyr Ser Leu Ala Asp Val Asp 
        675                 680                 685             


Val Tyr Asn Pro Ile Ser Val Val Tyr Leu Ser Arg Asp Thr Cys Val 
    690                 695                 700                 


Ser Glu His Gly Val Ile Glu Thr Val Ala Leu Pro His Pro Asp Asn 
705                 710                 715                 720 


Leu Lys Glu Cys Leu Tyr Cys Gly Ser Val Phe Leu Arg Tyr Leu Thr 
                725                 730                 735     


Thr Gly Ala Ile Met Asp Ile Ile Ile Ile Asp Ser Lys Asp Thr Glu 
            740                 745                 750         


Arg Gln Leu Ala Ala Met Gly Asn Ser Thr Ile Pro Pro Phe Asn Pro 
        755                 760                 765             


Asp Met His Gly Asp Asp Ser Lys Ala Val Leu Leu Phe Pro Asn Gly 
    770                 775                 780                 


Thr Val Val Thr Leu Leu Gly Phe Glu Arg Arg Gln Ala Ile Arg Met 
785                 790                 795                 800 


Ser Gly Gln Tyr Leu Gly Ala Ser Leu Gly Gly Ala Phe Leu Ala Val 
                805                 810                 815     


Val Gly Phe Gly Ile Ile Gly Trp Met Leu Cys Gly Asn Ser Arg Leu 
            820                 825                 830         


Arg Glu Tyr Asn Lys Ile Pro Leu Thr 
        835                 840     


<210>  551
<211>  483
<212>  DNA
<213>  Varicellovirus Varicella virus

<400>  551
atggcatcac ataaatggtt actgcagatg atagtttttt taaaaactat cacaatcgcg       60

tattgtcttc atctccaaga cgacactccg ttgttttttg gagccaaacc gctatcggat      120

gtgagtttga ttataacgga accgtgcgtg tcatcggtat atgaggcgtg ggactatgcg      180

gcacccccgg tatcaaacct cagcgaggcg ctatcgggaa tcgtggttaa gacaaaatgt      240

ccagtaccgg aagttatact ttggtttaaa gacaaacaaa tggcgtactg gacaaatcca      300

tacgtcacct taaaggggct gacacaatct gttggtgaag aacataaaag cggggacata      360

cgcgatgctt tgttggatgc cctttccggt gtatgggtag actctactcc atcttccaca      420

aatatcccgg aaaatggatg tgtctgggga gccgaccgtt tgttccaacg cgtatgccaa      480

tga                                                                    483


<210>  552
<211>  160
<212>  PRT
<213>  Varicellovirus Varicella virus

<400>  552

Met Ala Ser His Lys Trp Leu Leu Gln Met Ile Val Phe Leu Lys Thr 
1               5                   10                  15      


Ile Thr Ile Ala Tyr Cys Leu His Leu Gln Asp Asp Thr Pro Leu Phe 
            20                  25                  30          


Phe Gly Ala Lys Pro Leu Ser Asp Val Ser Leu Ile Ile Thr Glu Pro 
        35                  40                  45              


Cys Val Ser Ser Val Tyr Glu Ala Trp Asp Tyr Ala Ala Pro Pro Val 
    50                  55                  60                  


Ser Asn Leu Ser Glu Ala Leu Ser Gly Ile Val Val Lys Thr Lys Cys 
65                  70                  75                  80  


Pro Val Pro Glu Val Ile Leu Trp Phe Lys Asp Lys Gln Met Ala Tyr 
                85                  90                  95      


Trp Thr Asn Pro Tyr Val Thr Leu Lys Gly Leu Thr Gln Ser Val Gly 
            100                 105                 110         


Glu Glu His Lys Ser Gly Asp Ile Arg Asp Ala Leu Leu Asp Ala Leu 
        115                 120                 125             


Ser Gly Val Trp Val Asp Ser Thr Pro Ser Ser Thr Asn Ile Pro Glu 
    130                 135                 140                 


Asn Gly Cys Val Trp Gly Ala Asp Arg Leu Phe Gln Arg Val Cys Gln 
145                 150                 155                 160 


<210>  553
<211>  1341
<212>  DNA
<213>  Orthohepadnavirus Hepatitis B virus

<400>  553
gccaccatgc agttaatcat tacttccaaa ctaggcatta tttacatact ctgtggaagg       60

ctggcattct atataagaga gaaactacac gcagtgcctc attttgtggg tcaccatatt      120

cttgggaaca agagctacag catgggaggt tggtcttcca aacctcgaca aggcatgggg      180

acgaatcttt ctgttcccaa tcctctggga ttctttcccg atcaccagtt ggaccctgcg      240

ttcggagcca actcaaacaa tccagattgg gacttcaacc ccaacaagga tcactggcca      300

gaggcaaagc aggtaggagc gggagcattc gggccagggt tcaccccacc acacggcggc      360

cttttggggt ggagccctca ggctcagggc acattgacaa cagtgccagc agcgcctcct      420

cctgcttcca ccaatcggca gtcaggaaga cagcctactc ccatctctcc acctctaaga      480

gacagtcatc ctcaggccat gcagtggaac tccacaacat tccaccaagc tctgctagat      540

ccaagagtga ggggcctcta tttccctgct ggtggctcca gttccggaac agtaaaccct      600

gttccgacta ctgcctcacc catatcgtca atcttctcga ggactgggga ccctgcaccg      660

aacatggaga gcacaacatc aggattccta ggacccctgc tcgtgttaca ggcggggttt      720

ttcttgttga caagaatcct cacaatacca cagagtctag actcgtggtt gacttctctc      780

aattttctag ggggaacacc caagtgtcct ggccaaaatt cgcagtcccc aacctccaat      840

cactcaccaa cctcttgtcc tccaacttgt cctggctatc gctggatgtg tctgcggcgt      900

tttatcatat tcctcttcat cctgctgcta tgcctcatct tcttgttggt tcttctggac      960

tacaaaggta tgttgcccgt ttgtcctcta cttccaggaa catcaactac cagcacggga     1020

ccatgcaaga cctgcacgat tcctgctcaa aacacctcta tgtttccctc ttgttgctgt     1080

acaaaacctt cggacggaaa ctgcacttgt attcccatcc catcatcctg ggctttcgca     1140

agattcctat gggagtgggc ctcagtccgt ttctcctggc tcagtttact agtgccattt     1200

gttcagtggt ctgcagggct ttcccccact gtttggcttt cagttatatg gacgatgtgg     1260

tattgggggc caagtctgta caacatcttg agtccctttt tacctctatt accaatttta     1320

tgttgtcttt gggcatacat t                                               1341


<210>  554
<211>  445
<212>  PRT
<213>  Orthohepadnavirus Hepatitis B virus

<400>  554

Met Gln Leu Ile Ile Thr Ser Lys Leu Gly Ile Ile Tyr Ile Leu Cys 
1               5                   10                  15      


Gly Arg Leu Ala Phe Tyr Ile Arg Glu Lys Leu His Ala Val Pro His 
            20                  25                  30          


Phe Val Gly His His Ile Leu Gly Asn Lys Ser Tyr Ser Met Gly Gly 
        35                  40                  45              


Trp Ser Ser Lys Pro Arg Gln Gly Met Gly Thr Asn Leu Ser Val Pro 
    50                  55                  60                  


Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro Ala Phe Gly 
65                  70                  75                  80  


Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn Lys Asp His 
                85                  90                  95      


Trp Pro Glu Ala Lys Gln Val Gly Ala Gly Ala Phe Gly Pro Gly Phe 
            100                 105                 110         


Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln Ala Gln Gly 
        115                 120                 125             


Thr Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala Ser Thr Asn Arg 
    130                 135                 140                 


Gln Ser Gly Arg Gln Pro Thr Pro Ile Ser Pro Pro Leu Arg Asp Ser 
145                 150                 155                 160 


His Pro Gln Ala Met Gln Trp Asn Ser Thr Thr Phe His Gln Ala Leu 
                165                 170                 175     


Leu Asp Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser 
            180                 185                 190         


Ser Gly Thr Val Asn Pro Val Pro Thr Thr Ala Ser Pro Ile Ser Ser 
        195                 200                 205             


Ile Phe Ser Arg Thr Gly Asp Pro Ala Pro Asn Met Glu Ser Thr Thr 
    210                 215                 220                 


Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu 
225                 230                 235                 240 


Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Leu Thr 
                245                 250                 255     


Ser Leu Asn Phe Leu Gly Gly Thr Pro Lys Cys Pro Gly Gln Asn Ser 
            260                 265                 270         


Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Thr Cys 
        275                 280                 285             


Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe 
    290                 295                 300                 


Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Lys 
305                 310                 315                 320 


Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Thr Ser Thr Thr Ser 
                325                 330                 335     


Thr Gly Pro Cys Lys Thr Cys Thr Ile Pro Ala Gln Asn Thr Ser Met 
            340                 345                 350         


Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr Cys 
        355                 360                 365             


Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Arg Phe Leu Trp Glu Trp 
    370                 375                 380                 


Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln 
385                 390                 395                 400 


Trp Ser Ala Gly Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Thr 
                405                 410                 415     


Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile Leu Ser Pro Phe Leu 
            420                 425                 430         


Pro Leu Leu Pro Ile Leu Cys Cys Leu Trp Ala Tyr Ile 
        435                 440                 445 


<210>  555
<211>  849
<212>  DNA
<213>  Orthohepadnavirus Hepatitis B virus

<400>  555
gccaccatgc agtggaactc cacgacgttc catcaggcgt tgcaggatcc tcgcgtgagg       60

ggactctact ttccggccgg gggctcctct agtggcacag tcaatcctgt gcccacaacg      120

gcaagcttga tttcctcaat cttttcacgc atcggcgacc cagcaccgaa catggagtct      180

attacttctg gtttcctggg ccccctcctc gtgttgcaag ccggtttctt cctcctgacc      240

aaaatactca ccatacccca gtctctggat agttggtgga cgagcctgaa tttccttggt      300

ggagctcccg tttgcctcgg tcagaatagc caatcaccca cttccaacca ctcacctacg      360

tcctgtccac ctatctgccc tggataccgc tggatgtgct tgcggcggtt tataattttc      420

ctcttcatcc tccttttatg tctgattttt ctcctggttt tgctggatta ccagggtatg      480

ctgcctgtgt gtcccctcat cccaggaagc agcacgacct ctactggtcc atgccgcacc      540

tgcatgactc tggctcaggg aacttccatg tttccgtcct gttgttgctc caagccttct      600

gatgggaatt gcacttgtat acctatccct agtagttggg ccttcgggaa gttcttgtgg      660

gagtgggcgt cagcccgttt ctcctggctg agcttgttag taccttttgt ccaatggttc      720

gcaggcctgt ctccaacagt gtggttatcc gtgatttgga tgatgtggta ttggggccct      780

agcctctatg atatcctgag tccttttatc cctctgctgc caatcttctt ttgcctttgg      840

gtgtacatc                                                              849


<210>  556
<211>  281
<212>  PRT
<213>  Orthohepadnavirus Hepatitis B virus

<400>  556

Met Gln Trp Asn Ser Thr Thr Phe His Gln Ala Leu Gln Asp Pro Arg 
1               5                   10                  15      


Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly Ser Ser Ser Gly Thr Val 
            20                  25                  30          


Asn Pro Val Pro Thr Thr Ala Ser Leu Ile Ser Ser Ile Phe Ser Arg 
        35                  40                  45              


Ile Gly Asp Pro Ala Pro Asn Met Glu Ser Ile Thr Ser Gly Phe Leu 
    50                  55                  60                  


Gly Pro Leu Leu Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Lys Ile 
65                  70                  75                  80  


Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe 
                85                  90                  95      


Leu Gly Gly Ala Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr 
            100                 105                 110         


Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg 
        115                 120                 125             


Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu 
    130                 135                 140                 


Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro 
145                 150                 155                 160 


Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser Thr Gly Pro Cys 
                165                 170                 175     


Arg Thr Cys Met Thr Leu Ala Gln Gly Thr Ser Met Phe Pro Ser Cys 
            180                 185                 190         


Cys Cys Ser Lys Pro Ser Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro 
        195                 200                 205             


Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu Trp Ala Ser Ala Arg 
    210                 215                 220                 


Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Ala Gly 
225                 230                 235                 240 


Leu Ser Pro Thr Val Trp Leu Ser Val Ile Trp Met Met Trp Tyr Trp 
                245                 250                 255     


Gly Pro Ser Leu Tyr Asp Ile Leu Ser Pro Phe Ile Pro Leu Leu Pro 
            260                 265                 270         


Ile Phe Phe Cys Leu Trp Val Tyr Ile 
        275                 280     


<210>  557
<211>  684
<212>  DNA
<213>  Orthohepadnavirus Hepatitis B virus

<400>  557
gccaccatgg aaagcattac ttccggcttt ctcggcccgt tactggtgct tcaggctgga       60

ttctttctgc tcaccaaaat ccttacaatt ccacagtctc ttgattcatg gtggactagt      120

ttgaattttc tggggggagc accagtctgc ctgggtcaga actcccagtc tccgacaagt      180

aaccatagcc caaccagttg tcctccgata tgccccggct ataggtggat gtgtcttcgc      240

cgcttcatta ttttcctgtt cattttgctt ctttgcttaa tctttctgct tgtgcttctg      300

gactaccagg gtatgcttcc tgtatgcccg ctgatccctg gttcatcaac cacgtccacc      360

gggccttgcc ggacttgcat gactttggcc caggggactt ctatgttccc aagctgttgc      420

tgttcaaaac cctccgacgg gaactgtacc tgtatcccca ttccttccag ttgggccttt      480

ggaaaattcc tctgggagtg ggcttccgca cggttcagct ggctttcact gcttgttcca      540

tttgtacagt ggtttgccgg gctgtctcct accgtgtggc tcagcgttat atggatgatg      600

tggtattggg gaccatcact ctacgacatt ctgtccccat tcatcccact gttgcctatt      660

ttcttttgct tatgggtata catc                                             684


<210>  558
<211>  226
<212>  PRT
<213>  Orthohepadnavirus Hepatitis B virus

<400>  558

Met Glu Ser Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Met Thr Leu Ala 
        115                 120                 125             


Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Ser Lys Pro Ser Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys 
145                 150                 155                 160 


Phe Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Ala Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asp Ile 
        195                 200                 205             


Leu Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile 
225     


<210>  559
<211>  2949
<212>  DNA
<213>  Alphavirus Eastern equine encephalitis virus

<400>  559
atgtcgctcg ccactgtcat gtgcgtcctg gccaatatca cgtttccatg tgatcaacca       60

ccctgcatgc catgctgtta tgaaaagaat ccacacgaaa cactcaccat gctggaacag      120

aattacgaca gccgagccta tgatcagctg ctcgatgccg ctgtgaaatg taatgctagg      180

agaaccagga gagatttgga cactcatttc acccagtata agttggcacg cccgtatatt      240

gctgattgcc ctaactgtgg gcatagtcgg tgcgacagcc ctatagctat agaagaagtc      300

agaggggatg cgcatgcagg agtcatccgc atccagacat cagctatgtt tggtctgaag      360

acggatggag tcgatttggc ctacatgagt ttcatgaacg gcaaaacgca gaaatcaata      420

aagatcgaca acctgcatgt gcgcacctca gccccttgtt ccctcgtgtc gcaccacggc      480

tattacatct tggctcaatg cccaccaggg gacacggtta cagttgggtt tcacgacggg      540

cctaaccgcc atacgtgcac agttgcccat aaggtagaat tcaggccagt gggtagagag      600

aaataccgtc acccacctga acatggagtt gaattaccgt gtaaccgtta cactcacaag      660

cgtgcagacc aaggacacta tgttgagatg catcaaccag ggctagttgc cgaccactct      720

ctccttagca tccacagtgc caaggtgaaa attacggtac cgagcggcgc ccaagtgaaa      780

tactactgca agtgtccaga tgtacgagag ggaattacca gcagcgacca tacaaccacc      840

tgcacggatg tcaaacaatg cagggcttac ctgattgaca acaagaaatg ggtgtacaac      900

tctggaagac tgcctcgagg agagggcgac acttttaaag gaaaacttca tgtgcccttt      960

gtgcctgtta aggccaagtg catcgccacg ctggcaccgg agcctctagt tgagcacaaa     1020

caccgcaccc tgattttaca cctgcacccg gaccacccga ccttgctgac gaccaggtca     1080

cttggaagtg atgcaaatcc aactcgacaa tggattgagc gaccaacaac tgtcaatttc     1140

acagtcaccg gagaagggtt ggagtatacc tggggaaacc atccaccaaa aagagtatgg     1200

gctcaagagt caggagaagg gaacccacat ggatggccgc acgaagtggt agtctattac     1260

tacaacagat acccgctaac cacaattatc gggttatgca cctgtgtggc tatcatcatg     1320

gtctcttgtg tcacatccgt gtggctcctt tgcaggactc gcaatctttg cataaccccg     1380

tataaactag ccccgaacgc tcaagtccca atactcctgg cgttactttg ctgcattaag     1440

ccgacgaggg cagacgacac cttgcaagtg ctgaattatc tgtggaacaa caatcaaaac     1500

tttttctgga tgcagacgct tatcccactt gcagcgctta tcgtatgcat gcgcatgctg     1560

cgttgcttat tttgctgtgg gccggctttt ttacttgtct gcggcgcctt gggcgccgca     1620

gcgtacgaac acacagcagt gatgccgaac aaggtgggga tcccgtataa agctttagtc     1680

gaacgcccag ggtatgcacc cgttcaccta cagatacagc tggttaatac caggataatt     1740

ccatcaacta acctggagta catcacctgc aagtacaaga caaaagtgcc gtctccagta     1800

gtgaaatgct gcggtgccac tcaatgtacc tctaaacccc atcctgacta tcagtgtcag     1860

gtgtttacag gtgtttaccc attcatgtgg ggaggagcct actgcttctg cgacaccgaa     1920

aacacccaga tgagcgaggc gtatgtagag cgctcggaag agtgctctat cgaccacgca     1980

aaagcttata aagtacacac aggcactgtt caggcaatgg tgaacataac ttatgggagc     2040

gtcagctgga gatctgcaga tgtctacgtc aatggtgaaa ctcccgcgaa aataggagat     2100

gccaaactca tcataggtcc actgtcatct gcgtggtccc cattcgataa caaggtggtg     2160

gtttatgggc atgaagtgta taattacgac tttcctgagt acagcaccgg caaagcaggc     2220

tctttcggag acctgcaatc acgcacatca accagcaacg atctgtacgc aaataccaac     2280

ttgaagctac aacgacccca ggctggtatc gtgcacacac ctttcaccca ggcgccctct     2340

ggcttcgaac gatggaaaag ggacaaaggg gcaccgttga acgacgtagc cccgtttggc     2400

tgttcaattg ccctggagcc gctccgtgca gaaaattgtg cagtgggaag catccctata     2460

tctatagata tacccgatgc ggctttcacc agaatatctg aaacaccgac agtctcagac     2520

ctggaatgca aaattacgga gtgtacttat gcctccgatt tcggtggtat agccaccgtt     2580

gcctacaaat ccagtaaagc aggaaactgt ccaattcatt ctccatcggg tgttgcagtt     2640

attaaagaga atgacgtcac ccttgctgag agcggatcat ttacattcca cttctccact     2700

gcaaacatcc atcctgcttt taagctgcag gtctgcacca gtgcagttac ctgcaaagga     2760

gattgcaagc caccgaaaga tcatatcgtc gattatccag cacaacatac cgaatccttt     2820

acgtcggcga tatccgccac cgcgtggtcg tggctaaaag tgctggtagg aggaacatca     2880

gcatttattg ttctggggct tattgctaca gcagtggttg ccctagttct gttcttccat     2940

agacattaa                                                             2949


<210>  560
<211>  982
<212>  PRT
<213>  Alphavirus Eastern equine encephalitis virus

<400>  560

Met Ser Leu Ala Thr Val Met Cys Val Leu Ala Asn Ile Thr Phe Pro 
1               5                   10                  15      


Cys Asp Gln Pro Pro Cys Met Pro Cys Cys Tyr Glu Lys Asn Pro His 
            20                  25                  30          


Glu Thr Leu Thr Met Leu Glu Gln Asn Tyr Asp Ser Arg Ala Tyr Asp 
        35                  40                  45              


Gln Leu Leu Asp Ala Ala Val Lys Cys Asn Ala Arg Arg Thr Arg Arg 
    50                  55                  60                  


Asp Leu Asp Thr His Phe Thr Gln Tyr Lys Leu Ala Arg Pro Tyr Ile 
65                  70                  75                  80  


Ala Asp Cys Pro Asn Cys Gly His Ser Arg Cys Asp Ser Pro Ile Ala 
                85                  90                  95      


Ile Glu Glu Val Arg Gly Asp Ala His Ala Gly Val Ile Arg Ile Gln 
            100                 105                 110         


Thr Ser Ala Met Phe Gly Leu Lys Thr Asp Gly Val Asp Leu Ala Tyr 
        115                 120                 125             


Met Ser Phe Met Asn Gly Lys Thr Gln Lys Ser Ile Lys Ile Asp Asn 
    130                 135                 140                 


Leu His Val Arg Thr Ser Ala Pro Cys Ser Leu Val Ser His His Gly 
145                 150                 155                 160 


Tyr Tyr Ile Leu Ala Gln Cys Pro Pro Gly Asp Thr Val Thr Val Gly 
                165                 170                 175     


Phe His Asp Gly Pro Asn Arg His Thr Cys Thr Val Ala His Lys Val 
            180                 185                 190         


Glu Phe Arg Pro Val Gly Arg Glu Lys Tyr Arg His Pro Pro Glu His 
        195                 200                 205             


Gly Val Glu Leu Pro Cys Asn Arg Tyr Thr His Lys Arg Ala Asp Gln 
    210                 215                 220                 


Gly His Tyr Val Glu Met His Gln Pro Gly Leu Val Ala Asp His Ser 
225                 230                 235                 240 


Leu Leu Ser Ile His Ser Ala Lys Val Lys Ile Thr Val Pro Ser Gly 
                245                 250                 255     


Ala Gln Val Lys Tyr Tyr Cys Lys Cys Pro Asp Val Arg Glu Gly Ile 
            260                 265                 270         


Thr Ser Ser Asp His Thr Thr Thr Cys Thr Asp Val Lys Gln Cys Arg 
        275                 280                 285             


Ala Tyr Leu Ile Asp Asn Lys Lys Trp Val Tyr Asn Ser Gly Arg Leu 
    290                 295                 300                 


Pro Arg Gly Glu Gly Asp Thr Phe Lys Gly Lys Leu His Val Pro Phe 
305                 310                 315                 320 


Val Pro Val Lys Ala Lys Cys Ile Ala Thr Leu Ala Pro Glu Pro Leu 
                325                 330                 335     


Val Glu His Lys His Arg Thr Leu Ile Leu His Leu His Pro Asp His 
            340                 345                 350         


Pro Thr Leu Leu Thr Thr Arg Ser Leu Gly Ser Asp Ala Asn Pro Thr 
        355                 360                 365             


Arg Gln Trp Ile Glu Arg Pro Thr Thr Val Asn Phe Thr Val Thr Gly 
    370                 375                 380                 


Glu Gly Leu Glu Tyr Thr Trp Gly Asn His Pro Pro Lys Arg Val Trp 
385                 390                 395                 400 


Ala Gln Glu Ser Gly Glu Gly Asn Pro His Gly Trp Pro His Glu Val 
                405                 410                 415     


Val Val Tyr Tyr Tyr Asn Arg Tyr Pro Leu Thr Thr Ile Ile Gly Leu 
            420                 425                 430         


Cys Thr Cys Val Ala Ile Ile Met Val Ser Cys Val Thr Ser Val Trp 
        435                 440                 445             


Leu Leu Cys Arg Thr Arg Asn Leu Cys Ile Thr Pro Tyr Lys Leu Ala 
    450                 455                 460                 


Pro Asn Ala Gln Val Pro Ile Leu Leu Ala Leu Leu Cys Cys Ile Lys 
465                 470                 475                 480 


Pro Thr Arg Ala Asp Asp Thr Leu Gln Val Leu Asn Tyr Leu Trp Asn 
                485                 490                 495     


Asn Asn Gln Asn Phe Phe Trp Met Gln Thr Leu Ile Pro Leu Ala Ala 
            500                 505                 510         


Leu Ile Val Cys Met Arg Met Leu Arg Cys Leu Phe Cys Cys Gly Pro 
        515                 520                 525             


Ala Phe Leu Leu Val Cys Gly Ala Leu Gly Ala Ala Ala Tyr Glu His 
    530                 535                 540                 


Thr Ala Val Met Pro Asn Lys Val Gly Ile Pro Tyr Lys Ala Leu Val 
545                 550                 555                 560 


Glu Arg Pro Gly Tyr Ala Pro Val His Leu Gln Ile Gln Leu Val Asn 
                565                 570                 575     


Thr Arg Ile Ile Pro Ser Thr Asn Leu Glu Tyr Ile Thr Cys Lys Tyr 
            580                 585                 590         


Lys Thr Lys Val Pro Ser Pro Val Val Lys Cys Cys Gly Ala Thr Gln 
        595                 600                 605             


Cys Thr Ser Lys Pro His Pro Asp Tyr Gln Cys Gln Val Phe Thr Gly 
    610                 615                 620                 


Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Thr Glu 
625                 630                 635                 640 


Asn Thr Gln Met Ser Glu Ala Tyr Val Glu Arg Ser Glu Glu Cys Ser 
                645                 650                 655     


Ile Asp His Ala Lys Ala Tyr Lys Val His Thr Gly Thr Val Gln Ala 
            660                 665                 670         


Met Val Asn Ile Thr Tyr Gly Ser Val Ser Trp Arg Ser Ala Asp Val 
        675                 680                 685             


Tyr Val Asn Gly Glu Thr Pro Ala Lys Ile Gly Asp Ala Lys Leu Ile 
    690                 695                 700                 


Ile Gly Pro Leu Ser Ser Ala Trp Ser Pro Phe Asp Asn Lys Val Val 
705                 710                 715                 720 


Val Tyr Gly His Glu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Ser Thr 
                725                 730                 735     


Gly Lys Ala Gly Ser Phe Gly Asp Leu Gln Ser Arg Thr Ser Thr Ser 
            740                 745                 750         


Asn Asp Leu Tyr Ala Asn Thr Asn Leu Lys Leu Gln Arg Pro Gln Ala 
        755                 760                 765             


Gly Ile Val His Thr Pro Phe Thr Gln Ala Pro Ser Gly Phe Glu Arg 
    770                 775                 780                 


Trp Lys Arg Asp Lys Gly Ala Pro Leu Asn Asp Val Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Ser Ile Ala Leu Glu Pro Leu Arg Ala Glu Asn Cys Ala Val Gly 
                805                 810                 815     


Ser Ile Pro Ile Ser Ile Asp Ile Pro Asp Ala Ala Phe Thr Arg Ile 
            820                 825                 830         


Ser Glu Thr Pro Thr Val Ser Asp Leu Glu Cys Lys Ile Thr Glu Cys 
        835                 840                 845             


Thr Tyr Ala Ser Asp Phe Gly Gly Ile Ala Thr Val Ala Tyr Lys Ser 
    850                 855                 860                 


Ser Lys Ala Gly Asn Cys Pro Ile His Ser Pro Ser Gly Val Ala Val 
865                 870                 875                 880 


Ile Lys Glu Asn Asp Val Thr Leu Ala Glu Ser Gly Ser Phe Thr Phe 
                885                 890                 895     


His Phe Ser Thr Ala Asn Ile His Pro Ala Phe Lys Leu Gln Val Cys 
            900                 905                 910         


Thr Ser Ala Val Thr Cys Lys Gly Asp Cys Lys Pro Pro Lys Asp His 
        915                 920                 925             


Ile Val Asp Tyr Pro Ala Gln His Thr Glu Ser Phe Thr Ser Ala Ile 
    930                 935                 940                 


Ser Ala Thr Ala Trp Ser Trp Leu Lys Val Leu Val Gly Gly Thr Ser 
945                 950                 955                 960 


Ala Phe Ile Val Leu Gly Leu Ile Ala Thr Ala Val Val Ala Leu Val 
                965                 970                 975     


Leu Phe Phe His Arg His 
            980         


<210>  561
<211>  2946
<212>  DNA
<213>  Alphavirus Venezuelan equine encephalitis virus

<400>  561
atgtcactag tgaccactat gtgcctgctc gccaatgtga cgttcccatg tgccgaacca       60

ccaatttgct acgacagaaa accagcagag actttggcca tgctcagcgt taacgttgac      120

aacccgggct acgatgagct actggaagca gctgttaagt gccccggaag aaaaaggaga      180

tctaccaagg agctgtttaa ggagtataag ctaacgcgcc cttacatggc cagatgcatc      240

agatgtgccg ttgggagctg ccatagtcca atagcaattg aggcagtgaa gagcgacggg      300

cacgacggct atgttagact tcagacttcc tcgcagtatg gcctggattc ctctggcaac      360

ttaaagggaa ggactatgcg gtatgatatg cacgggacca ttgaagagat accactacat      420

caagtgtcac tccacacatc tcgcccgtgt cacattgtgg atgggcatgg ttattttctg      480

cttgctaggt gcccggcagg ggactccatc accatggaat ttaagaaagg ttcagtcaca      540

cactcctgct cagtgccgta tgaagtgaaa tttaatcctg taggcagaga actctacact      600

catccaccag aacacggagc agagcaagcg tgccaagtct acgcgcacga tgcacagaac      660

agaggagctt atgtcgagat gcacctcccg ggctcagaag tggacagcag tttgatttcc      720

ttgagcggca gttcagtcac cgtgacacct cctgtcggga ctagcgcctt ggtggaatgc      780

aagtgcggcg gcacaaagat ctccgaaacc atcaacaagg caaaacagtt cagccagtgc      840

acaaagaagg agcagtgcag agcatatcga ctgcagaatg acaagtgggt gtataattct      900

gacaaactgc ccaaagcagc gggagccacc ctaaaaggaa aactacacgt cccgttcttg      960

ctggcagacg gcaaatgcac cgtgcctcta gcaccggaac ctatgataac cttcggtttc     1020

cgatcagtgt cactgaaact gcaccctaag aatcccacat atctgaccac tcgccaactt     1080

gctgatgagc ctcattacac gcacgagctc atatctgaac cagctgttag gaattttacc     1140

gtcactgaaa aggggtggga gtttgtatgg ggaaaccatc cgccgaaaag gttttgggca     1200

caggaaacag cacccggaaa tccacatggg ctgccacatg aggtgataac tcattattac     1260

cacagatacc ctatgtccac catcctgggt ttgtcaattt gcgccgccat tgtaaccgtt     1320

tccgttgcag cgtccacctg gctgttttgc aaatccagag tttcgtgcct aactccttac     1380

cggctaacac ctaacgccag gatgccgctt tgcctggccg tgctttgctg cgcccgcact     1440

gcccgggccg agaccacctg ggagtccttg gatcacctat ggaacaataa ccaacagatg     1500

ttctggattc aattgctgat ccctctggcc gccttgattg tagtgactcg cctgctcaag     1560

tgcgtgtgct gtgtagtgcc ttttttagtc gtggccggcg ccgcaggcgc cggcgcctac     1620

gagcacgcga ccacgatgcc gagccaagcg ggaatctcgt ataacaccat agtcaacaga     1680

gcaggctacg cgccactccc tatcagcata acaccaacaa agatcaagct gatacccaca     1740

gtgaacttgg agtacgtcac ctgccactac aaaacaggaa tggattcacc agccatcaaa     1800

tgctgcggat ctcaggaatg tactccaact aacaggcctg atgaacagtg caaagtcttc     1860

acaggggttt acccgttcat gtggggaggt gcatattgct tttgcgacac tgagaatact     1920

caggtcagca aggcctacgt aatgaaatct gacgactgcc ttgcggatca tgctgaagca     1980

tacaaagcgc acacagcctc agtgcaggcg ttcctcaaca tcacagtggg ggaacactct     2040

attgtgacca ccgtgtatgt gaatggagaa actcctgtga acttcaatgg ggtcaaacta     2100

actgcaggtc cactttccac agcttggaca ccctttgaca gaaaaatcgt gcagtatgcc     2160

ggggagatct ataattacga ttttcctgag tatggggcag gacaaccagg agcatttgga     2220

gacatacaat ccagaacagt ctcaagctca gatctgtatg ccaataccaa cctagtgctg     2280

cagagaccca aagcaggagc gatccatgtg ccatacactc aggcaccatc gggttttgag     2340

caatggaaga aagataaagc tccgtcattg aaattcaccg cccctttcgg atgcgaaata     2400

tatacaaacc ccattcgcgc cgaaaattgt gctgtagggt caattccatt agcctttgac     2460

attcccgacg ccttgttcac cagggtgtca gaaacaccga cactttcagc ggccgaatgc     2520

actcttaacg agtgcgtgta ttcatccgac tttggcggga tcgccacggt caagtattcg     2580

gccagcaagt caggcaagtg cgcagtccat gtgccatcag ggactgctac cctaaaagaa     2640

gcagcagtcg agctaaccga gcaagggtcg gcgaccattc atttctcgac cgcaaatatc     2700

cacccggagt tcaggctcca aatatgcaca tcatatgtca cgtgcaaagg tgattgtcac     2760

cccccgaaag accacattgt gacacacccc cagtatcacg cccaaacatt tacagccgcg     2820

gtgtcaaaaa ccgcgtggac gtggttaaca tccctgctgg gaggatcggc cgtaattatt     2880

ataattggct tagtgctggc tactattgtg gccatgtacg tgctgaccaa ccagaaacat     2940

aattga                                                                2946


<210>  562
<211>  981
<212>  PRT
<213>  Alphavirus Venezuelan equine encephalitis virus

<400>  562

Met Ser Leu Val Thr Thr Met Cys Leu Leu Ala Asn Val Thr Phe Pro 
1               5                   10                  15      


Cys Ala Glu Pro Pro Ile Cys Tyr Asp Arg Lys Pro Ala Glu Thr Leu 
            20                  25                  30          


Ala Met Leu Ser Val Asn Val Asp Asn Pro Gly Tyr Asp Glu Leu Leu 
        35                  40                  45              


Glu Ala Ala Val Lys Cys Pro Gly Arg Lys Arg Arg Ser Thr Lys Glu 
    50                  55                  60                  


Leu Phe Lys Glu Tyr Lys Leu Thr Arg Pro Tyr Met Ala Arg Cys Ile 
65                  70                  75                  80  


Arg Cys Ala Val Gly Ser Cys His Ser Pro Ile Ala Ile Glu Ala Val 
                85                  90                  95      


Lys Ser Asp Gly His Asp Gly Tyr Val Arg Leu Gln Thr Ser Ser Gln 
            100                 105                 110         


Tyr Gly Leu Asp Ser Ser Gly Asn Leu Lys Gly Arg Thr Met Arg Tyr 
        115                 120                 125             


Asp Met His Gly Thr Ile Glu Glu Ile Pro Leu His Gln Val Ser Leu 
    130                 135                 140                 


His Thr Ser Arg Pro Cys His Ile Val Asp Gly His Gly Tyr Phe Leu 
145                 150                 155                 160 


Leu Ala Arg Cys Pro Ala Gly Asp Ser Ile Thr Met Glu Phe Lys Lys 
                165                 170                 175     


Gly Ser Val Thr His Ser Cys Ser Val Pro Tyr Glu Val Lys Phe Asn 
            180                 185                 190         


Pro Val Gly Arg Glu Leu Tyr Thr His Pro Pro Glu His Gly Ala Glu 
        195                 200                 205             


Gln Ala Cys Gln Val Tyr Ala His Asp Ala Gln Asn Arg Gly Ala Tyr 
    210                 215                 220                 


Val Glu Met His Leu Pro Gly Ser Glu Val Asp Ser Ser Leu Ile Ser 
225                 230                 235                 240 


Leu Ser Gly Ser Ser Val Thr Val Thr Pro Pro Val Gly Thr Ser Ala 
                245                 250                 255     


Leu Val Glu Cys Lys Cys Gly Gly Thr Lys Ile Ser Glu Thr Ile Asn 
            260                 265                 270         


Lys Ala Lys Gln Phe Ser Gln Cys Thr Lys Lys Glu Gln Cys Arg Ala 
        275                 280                 285             


Tyr Arg Leu Gln Asn Asp Lys Trp Val Tyr Asn Ser Asp Lys Leu Pro 
    290                 295                 300                 


Lys Ala Ala Gly Ala Thr Leu Lys Gly Lys Leu His Val Pro Phe Leu 
305                 310                 315                 320 


Leu Ala Asp Gly Lys Cys Thr Val Pro Leu Ala Pro Glu Pro Met Ile 
                325                 330                 335     


Thr Phe Gly Phe Arg Ser Val Ser Leu Lys Leu His Pro Lys Asn Pro 
            340                 345                 350         


Thr Tyr Leu Thr Thr Arg Gln Leu Ala Asp Glu Pro His Tyr Thr His 
        355                 360                 365             


Glu Leu Ile Ser Glu Pro Ala Val Arg Asn Phe Thr Val Thr Glu Lys 
    370                 375                 380                 


Gly Trp Glu Phe Val Trp Gly Asn His Pro Pro Lys Arg Phe Trp Ala 
385                 390                 395                 400 


Gln Glu Thr Ala Pro Gly Asn Pro His Gly Leu Pro His Glu Val Ile 
                405                 410                 415     


Thr His Tyr Tyr His Arg Tyr Pro Met Ser Thr Ile Leu Gly Leu Ser 
            420                 425                 430         


Ile Cys Ala Ala Ile Val Thr Val Ser Val Ala Ala Ser Thr Trp Leu 
        435                 440                 445             


Phe Cys Lys Ser Arg Val Ser Cys Leu Thr Pro Tyr Arg Leu Thr Pro 
    450                 455                 460                 


Asn Ala Arg Met Pro Leu Cys Leu Ala Val Leu Cys Cys Ala Arg Thr 
465                 470                 475                 480 


Ala Arg Ala Glu Thr Thr Trp Glu Ser Leu Asp His Leu Trp Asn Asn 
                485                 490                 495     


Asn Gln Gln Met Phe Trp Ile Gln Leu Leu Ile Pro Leu Ala Ala Leu 
            500                 505                 510         


Ile Val Val Thr Arg Leu Leu Lys Cys Val Cys Cys Val Val Pro Phe 
        515                 520                 525             


Leu Val Val Ala Gly Ala Ala Gly Ala Gly Ala Tyr Glu His Ala Thr 
    530                 535                 540                 


Thr Met Pro Ser Gln Ala Gly Ile Ser Tyr Asn Thr Ile Val Asn Arg 
545                 550                 555                 560 


Ala Gly Tyr Ala Pro Leu Pro Ile Ser Ile Thr Pro Thr Lys Ile Lys 
                565                 570                 575     


Leu Ile Pro Thr Val Asn Leu Glu Tyr Val Thr Cys His Tyr Lys Thr 
            580                 585                 590         


Gly Met Asp Ser Pro Ala Ile Lys Cys Cys Gly Ser Gln Glu Cys Thr 
        595                 600                 605             


Pro Thr Asn Arg Pro Asp Glu Gln Cys Lys Val Phe Thr Gly Val Tyr 
    610                 615                 620                 


Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Thr Glu Asn Thr 
625                 630                 635                 640 


Gln Val Ser Lys Ala Tyr Val Met Lys Ser Asp Asp Cys Leu Ala Asp 
                645                 650                 655     


His Ala Glu Ala Tyr Lys Ala His Thr Ala Ser Val Gln Ala Phe Leu 
            660                 665                 670         


Asn Ile Thr Val Gly Glu His Ser Ile Val Thr Thr Val Tyr Val Asn 
        675                 680                 685             


Gly Glu Thr Pro Val Asn Phe Asn Gly Val Lys Leu Thr Ala Gly Pro 
    690                 695                 700                 


Leu Ser Thr Ala Trp Thr Pro Phe Asp Arg Lys Ile Val Gln Tyr Ala 
705                 710                 715                 720 


Gly Glu Ile Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Gly Gln Pro 
                725                 730                 735     


Gly Ala Phe Gly Asp Ile Gln Ser Arg Thr Val Ser Ser Ser Asp Leu 
            740                 745                 750         


Tyr Ala Asn Thr Asn Leu Val Leu Gln Arg Pro Lys Ala Gly Ala Ile 
        755                 760                 765             


His Val Pro Tyr Thr Gln Ala Pro Ser Gly Phe Glu Gln Trp Lys Lys 
    770                 775                 780                 


Asp Lys Ala Pro Ser Leu Lys Phe Thr Ala Pro Phe Gly Cys Glu Ile 
785                 790                 795                 800 


Tyr Thr Asn Pro Ile Arg Ala Glu Asn Cys Ala Val Gly Ser Ile Pro 
                805                 810                 815     


Leu Ala Phe Asp Ile Pro Asp Ala Leu Phe Thr Arg Val Ser Glu Thr 
            820                 825                 830         


Pro Thr Leu Ser Ala Ala Glu Cys Thr Leu Asn Glu Cys Val Tyr Ser 
        835                 840                 845             


Ser Asp Phe Gly Gly Ile Ala Thr Val Lys Tyr Ser Ala Ser Lys Ser 
    850                 855                 860                 


Gly Lys Cys Ala Val His Val Pro Ser Gly Thr Ala Thr Leu Lys Glu 
865                 870                 875                 880 


Ala Ala Val Glu Leu Thr Glu Gln Gly Ser Ala Thr Ile His Phe Ser 
                885                 890                 895     


Thr Ala Asn Ile His Pro Glu Phe Arg Leu Gln Ile Cys Thr Ser Tyr 
            900                 905                 910         


Val Thr Cys Lys Gly Asp Cys His Pro Pro Lys Asp His Ile Val Thr 
        915                 920                 925             


His Pro Gln Tyr His Ala Gln Thr Phe Thr Ala Ala Val Ser Lys Thr 
    930                 935                 940                 


Ala Trp Thr Trp Leu Thr Ser Leu Leu Gly Gly Ser Ala Val Ile Ile 
945                 950                 955                 960 


Ile Ile Gly Leu Val Leu Ala Thr Ile Val Ala Met Tyr Val Leu Thr 
                965                 970                 975     


Asn Gln Lys His Asn 
            980     


<210>  563
<211>  2937
<212>  DNA
<213>  Alphavirus Western equine encephalitis virus

<400>  563
atgtcactag ttacagcact gtgcgtgctt tcgaatgtta cgttcccatg cgataaacca       60

cccgtgtgct attcactggc gccagaacga acactcgacg tgctcgagga gaacgtcaac      120

aatccaaatt acgacacgct gctggagaac gtcttgaaat gtccgtcacg ccggcccaaa      180

cgaagcatta ccgatgactt cacactgacc agtccctacc tagggttctg cccgtattgc      240

agacactcag cgccgtgttt cagcccaata aaaattgaga acgtgtggga cgaatctgat      300

gatggatcga ttagaatcca ggtctcggca caattcggct atgatcaggc aggcactgca      360

gatgtcacca aattccgtta catgtcttac gaccacgacc atgacatcaa ggaagacagt      420

gtgaagaaaa tagctattag tacatctgga ccctgccgtc gtcttggcca caaagggtac      480

ttcctgttag ctcaatgtcc tccaggtgac agtgtaaccg tcagtatcac gagcggagca      540

tctgagaatt catgcaccgt ggagaaaaag atcaggagga agtttgtcgg tagagaggag      600

tacttgttcc cacctgtcca tggaaagctg gtaaagtgcc acgtttacga tcacttgaag      660

gagacgtctg ccggatacat aaccatgcac aggccaggcc cacacgcgta taagtcctat      720

ctggaggaag cgtcaggcga agtgtacatt aaaccacctt ctggcaagaa cgtcacctac      780

gaatgtaagt gtggcgacta cagcacaggt attgtgagca cgcgaacgaa gatgaacggc      840

tgcaccaaag caaaacagtg cattgcctac aagagcgacc aaacgaaatg ggtctacaac      900

tcgccggatc ttattaggca cacagaccac tcagtgcaag gtaaactgca cattccattc      960

cgcttgacac cgacattctg cccggttccg ttagctcaca cgcctacagt cacgaagtgg     1020

tttaaaggca tcaccctcca cctgactgca acgcgaccaa cattgctgac aacgagaaaa     1080

ttggggctgc gagcagacgc aacagcagaa tggattacag ggactacatc caggaatttt     1140

tctgtggggc gagaagggct ggagtacgta tggggcaacc atgaaccagt cagagtctgg     1200

gcccaggagt cggcaccagg cgacccgcat ggatggccgc atgagatcat catccactat     1260

tatcatcggc atccagtcta cactgtcatt gtgctgtgcg gtgtcgctct tgctatcctg     1320

gtaggcattg catcgtcagc agcttgtatc gccaaagcaa gaagagactg cctgacgcca     1380

tacgcgcttg caccgaacgc aacggtaccc acagcattag cagttttgtg ctgtattcgg     1440

ccaaccaacg cagaaacatt tggagaaact ttgaatcatc tgtggtttaa caaccaaccg     1500

tttctctggg cacagttgtg catccctctg gcagcgctta ttattctgtt tcgctgcttt     1560

tcatgctgca tgcctttttt attggttgca ggcgtctgcc tggggaaggt agacgccttc     1620

gaacatgcga ccactgtgcc aaatgttccg gggatcccgt ataaggcgtt ggtcgaacgt     1680

gcaggttacg cgccacttaa tctggagatt acggtcgtct catcggaatt aacaccctca     1740

actaacaagg agtatgtgac ctgcaaattc cacacagtca ttccttcacc gcaagttaaa     1800

tgctgcgggt ccctcgagtg taaggcatcc tcaaaagcgg attacacatg ccgcgttttt     1860

ggcggtgtgt accctttcat gtggggaggc gcacagtgct tctgtgacag tgagaacaca     1920

caactgagtg aggcatacgt cgagttcgct ccagactgca ctatagatca tgcagtcgca     1980

ctaaaagttc acacagctgc tctgaaagtc ggcctgcgta tagtatacgg caataccacc     2040

gcgcacctgg atacgttcgt caatggcgtc acgccaggtt cctcacggga cctgaaggtc     2100

atagcagggc cgatatcagc cgctttttca ccctttgacc ataaggtcgt catcagaaag     2160

gggcttgttt ataactacga cttccctgag tatggagcta tgaaaccagg agcgttcggc     2220

gatattcaag catcctcgct tgatgccaca gacatagtag cccgcactga catacggctg     2280

ctgaagcctt ctgtcaagaa catccacgtc ccctacaccc aagcagtatc agggtatgaa     2340

atgtggaaga acaactcagg acgacccctg caagaaacag caccatttgg atgtaaaatt     2400

gaagtggagc ctctgcgagc gtctaattgt gcttatgggc acatccctat ctcgattgac     2460

atccctgatg cagcttttgt gagatcatca gaatcaccaa caattttaga agtcagctgc     2520

acagtagcag actgcattta ttctgcagac tttggtggtt cgctaacact acagtacaaa     2580

gctgacaggg agggacattg tccagttcac tcccactcca ctacagctgt tttgaaggaa     2640

gcgaccacac atgtgactgc cacaggcagc ataacactac attttagcac atcgagccca     2700

caagcaaatt tcatagtttc gctatgcggc aagaagacca cttgcaatgc tgaatgtaaa     2760

ccaccggccg accacataat tggagaacca cataaggtcg accaagaatt ccaggcggca     2820

gtttccaaaa catcttggaa ctggctgctt gcactgtttg ggggagcatc atccctcatt     2880

gctgtaggac ttatagtgtt ggtctgcagc tctatgctta taaacacacg tagatga        2937


<210>  564
<211>  978
<212>  PRT
<213>  Alphavirus Western equine encephalitis virus

<400>  564

Met Ser Leu Val Thr Ala Leu Cys Val Leu Ser Asn Val Thr Phe Pro 
1               5                   10                  15      


Cys Asp Lys Pro Pro Val Cys Tyr Ser Leu Ala Pro Glu Arg Thr Leu 
            20                  25                  30          


Asp Val Leu Glu Glu Asn Val Asn Asn Pro Asn Tyr Asp Thr Leu Leu 
        35                  40                  45              


Glu Asn Val Leu Lys Cys Pro Ser Arg Arg Pro Lys Arg Ser Ile Thr 
    50                  55                  60                  


Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Phe Cys Pro Tyr Cys 
65                  70                  75                  80  


Arg His Ser Ala Pro Cys Phe Ser Pro Ile Lys Ile Glu Asn Val Trp 
                85                  90                  95      


Asp Glu Ser Asp Asp Gly Ser Ile Arg Ile Gln Val Ser Ala Gln Phe 
            100                 105                 110         


Gly Tyr Asp Gln Ala Gly Thr Ala Asp Val Thr Lys Phe Arg Tyr Met 
        115                 120                 125             


Ser Tyr Asp His Asp His Asp Ile Lys Glu Asp Ser Val Lys Lys Ile 
    130                 135                 140                 


Ala Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Gly His Lys Gly Tyr 
145                 150                 155                 160 


Phe Leu Leu Ala Gln Cys Pro Pro Gly Asp Ser Val Thr Val Ser Ile 
                165                 170                 175     


Thr Ser Gly Ala Ser Glu Asn Ser Cys Thr Val Glu Lys Lys Ile Arg 
            180                 185                 190         


Arg Lys Phe Val Gly Arg Glu Glu Tyr Leu Phe Pro Pro Val His Gly 
        195                 200                 205             


Lys Leu Val Lys Cys His Val Tyr Asp His Leu Lys Glu Thr Ser Ala 
    210                 215                 220                 


Gly Tyr Ile Thr Met His Arg Pro Gly Pro His Ala Tyr Lys Ser Tyr 
225                 230                 235                 240 


Leu Glu Glu Ala Ser Gly Glu Val Tyr Ile Lys Pro Pro Ser Gly Lys 
                245                 250                 255     


Asn Val Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Ser Thr Gly Ile Val 
            260                 265                 270         


Ser Thr Arg Thr Lys Met Asn Gly Cys Thr Lys Ala Lys Gln Cys Ile 
        275                 280                 285             


Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Tyr Asn Ser Pro Asp Leu 
    290                 295                 300                 


Ile Arg His Thr Asp His Ser Val Gln Gly Lys Leu His Ile Pro Phe 
305                 310                 315                 320 


Arg Leu Thr Pro Thr Phe Cys Pro Val Pro Leu Ala His Thr Pro Thr 
                325                 330                 335     


Val Thr Lys Trp Phe Lys Gly Ile Thr Leu His Leu Thr Ala Thr Arg 
            340                 345                 350         


Pro Thr Leu Leu Thr Thr Arg Lys Leu Gly Leu Arg Ala Asp Ala Thr 
        355                 360                 365             


Ala Glu Trp Ile Thr Gly Thr Thr Ser Arg Asn Phe Ser Val Gly Arg 
    370                 375                 380                 


Glu Gly Leu Glu Tyr Val Trp Gly Asn His Glu Pro Val Arg Val Trp 
385                 390                 395                 400 


Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro His Glu Ile 
                405                 410                 415     


Ile Ile His Tyr Tyr His Arg His Pro Val Tyr Thr Val Ile Val Leu 
            420                 425                 430         


Cys Gly Val Ala Leu Ala Ile Leu Val Gly Ile Ala Ser Ser Ala Ala 
        435                 440                 445             


Cys Ile Ala Lys Ala Arg Arg Asp Cys Leu Thr Pro Tyr Ala Leu Ala 
    450                 455                 460                 


Pro Asn Ala Thr Val Pro Thr Ala Leu Ala Val Leu Cys Cys Ile Arg 
465                 470                 475                 480 


Pro Thr Asn Ala Glu Thr Phe Gly Glu Thr Leu Asn His Leu Trp Phe 
                485                 490                 495     


Asn Asn Gln Pro Phe Leu Trp Ala Gln Leu Cys Ile Pro Leu Ala Ala 
            500                 505                 510         


Leu Ile Ile Leu Phe Arg Cys Phe Ser Cys Cys Met Pro Phe Leu Leu 
        515                 520                 525             


Val Ala Gly Val Cys Leu Gly Lys Val Asp Ala Phe Glu His Ala Thr 
    530                 535                 540                 


Thr Val Pro Asn Val Pro Gly Ile Pro Tyr Lys Ala Leu Val Glu Arg 
545                 550                 555                 560 


Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Val Ser Ser Glu 
                565                 570                 575     


Leu Thr Pro Ser Thr Asn Lys Glu Tyr Val Thr Cys Lys Phe His Thr 
            580                 585                 590         


Val Ile Pro Ser Pro Gln Val Lys Cys Cys Gly Ser Leu Glu Cys Lys 
        595                 600                 605             


Ala Ser Ser Lys Ala Asp Tyr Thr Cys Arg Val Phe Gly Gly Val Tyr 
    610                 615                 620                 


Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser Glu Asn Thr 
625                 630                 635                 640 


Gln Leu Ser Glu Ala Tyr Val Glu Phe Ala Pro Asp Cys Thr Ile Asp 
                645                 650                 655     


His Ala Val Ala Leu Lys Val His Thr Ala Ala Leu Lys Val Gly Leu 
            660                 665                 670         


Arg Ile Val Tyr Gly Asn Thr Thr Ala His Leu Asp Thr Phe Val Asn 
        675                 680                 685             


Gly Val Thr Pro Gly Ser Ser Arg Asp Leu Lys Val Ile Ala Gly Pro 
    690                 695                 700                 


Ile Ser Ala Ala Phe Ser Pro Phe Asp His Lys Val Val Ile Arg Lys 
705                 710                 715                 720 


Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Met Lys Pro 
                725                 730                 735     


Gly Ala Phe Gly Asp Ile Gln Ala Ser Ser Leu Asp Ala Thr Asp Ile 
            740                 745                 750         


Val Ala Arg Thr Asp Ile Arg Leu Leu Lys Pro Ser Val Lys Asn Ile 
        755                 760                 765             


His Val Pro Tyr Thr Gln Ala Val Ser Gly Tyr Glu Met Trp Lys Asn 
    770                 775                 780                 


Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly Cys Lys Ile 
785                 790                 795                 800 


Glu Val Glu Pro Leu Arg Ala Ser Asn Cys Ala Tyr Gly His Ile Pro 
                805                 810                 815     


Ile Ser Ile Asp Ile Pro Asp Ala Ala Phe Val Arg Ser Ser Glu Ser 
            820                 825                 830         


Pro Thr Ile Leu Glu Val Ser Cys Thr Val Ala Asp Cys Ile Tyr Ser 
        835                 840                 845             


Ala Asp Phe Gly Gly Ser Leu Thr Leu Gln Tyr Lys Ala Asp Arg Glu 
    850                 855                 860                 


Gly His Cys Pro Val His Ser His Ser Thr Thr Ala Val Leu Lys Glu 
865                 870                 875                 880 


Ala Thr Thr His Val Thr Ala Thr Gly Ser Ile Thr Leu His Phe Ser 
                885                 890                 895     


Thr Ser Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys Gly Lys Lys 
            900                 905                 910         


Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His Ile Ile Gly 
        915                 920                 925             


Glu Pro His Lys Val Asp Gln Glu Phe Gln Ala Ala Val Ser Lys Thr 
    930                 935                 940                 


Ser Trp Asn Trp Leu Leu Ala Leu Phe Gly Gly Ala Ser Ser Leu Ile 
945                 950                 955                 960 


Ala Val Gly Leu Ile Val Leu Val Cys Ser Ser Met Leu Ile Asn Thr 
                965                 970                 975     


Arg Arg 
        


<210>  565
<211>  2964
<212>  DNA
<213>  Alphavirus Semliki Forest virus

<400>  565
atgtccgccc cgctgattac tgccatgtgt gtccttgcca atgctacctt cccgtgcttc       60

cagcccccgt gtgtaccttg ctgctatgaa aacaacgcag aggccacact acggatgctc      120

gaggataacg tggataggcc agggtactac gacctccttc aggcagcctt gacgtgccga      180

aacggaacaa gacaccggcg cagcgtgtcg caacacttca acgtgtataa ggctacacgc      240

ccttacatcg cgtactgcgc cgactgcgga gcagggcact cgtgtcatag ccccgtagca      300

attgaagcgg tcaggtccga agctaccgac gggatgctga agattcagtt ctcggcacaa      360

attggcatag ataagagtga caatcatgac tacacgaaga taaggtacgc agacgggcac      420

gccattgaga atgccgtccg gtcatctttg aaggtagcca cctccggaga ctgtttcgtc      480

catggcacaa tgggacattt catactggca aagtgcccac cgggtgaatt cctgcaggtc      540

tcgatccagg acaccagaaa cgcggtccgt gcctgcagaa tacaatatca tcatgaccct      600

caaccggtgg gtagagaaaa atttacaatt agaccacact atggaaaaga gatcccttgc      660

accacttatc aacagaccac agcggagacc gtggaggaaa tcgacatgca tatgccgcca      720

gatacgccgg acaggacgtt gctatcacag caatctggca atgtaaagat cacagtcgga      780

ggaaagaagg tgaaatacaa ctgcacctgt ggaaccggaa acgttggcac tactaattcg      840

gacatgacga tcaacacgtg tctaatagag cagtgccacg tctcagtgac ggaccataag      900

aaatggcagt tcaactcacc tttcgtcccg agagccgacg aaccggctag aaaaggcaaa      960

gtccatatcc cattcccgtt ggacaacatc acatgcagag ttccaatggc gcgcgaacca     1020

accgtcatcc acggcaaaag agaagtgaca ctgcaccttc acccagatca tcccacgctc     1080

ttttcctacc gcacactggg tgaggacccg cagtatcacg aggaatgggt gacagcggcg     1140

gtggaacgga ccatacccgt accagtggac gggatggagt accactgggg aaacaacgac     1200

ccagtgaggc tttggtctca actcaccact gaagggaaac cgcacggctg gccgcatcag     1260

atcgtacagt actactatgg gctttacccg gccgctacag tatccgcggt cgtcgggatg     1320

agcttactgg cgttgatatc gatcttcgcg tcgtgctaca tgctggttgc ggcccgcagt     1380

aagtgcttga ccccttatgc tttaacacca ggagctgcag ttccgtggac gctggggata     1440

ctctgctgcg ccccgcgggc gcacgcagct agtgtggcag agactatggc ctacttgtgg     1500

gaccaaaacc aagcgttgtt ctggttggag tttgcggccc ctgttgcctg catcctcatc     1560

atcacgtatt gcctcagaaa cgtgctgtgt tgctgtaaga gcctttcttt tttagtgcta     1620

ctgagcctcg gggcaaccgc cagagcttac gaacattcga cagtaatgcc gaacgtggtg     1680

gggttcccgt ataaggctca cattgaaagg ccaggatata gccccctcac tttgcagatg     1740

caggttgttg aaaccagcct cgaaccaacc cttaatttgg aatacataac ctgtgagtac     1800

aagacggtcg tcccgtcgcc gtacgtgaag tgctgcggcg cctcagagtg ctccactaaa     1860

gagaagcctg actaccaatg caaggtttac acaggcgtgt acccgttcat gtggggaggg     1920

gcatattgct tctgcgactc agaaaacacg caactcagcg aggcgtacgt cgatcgatcg     1980

gacgtatgca ggcatgatca cgcatctgct tacaaagccc atacagcatc gctgaaggcc     2040

aaagtgaggg ttatgtacgg caacgtaaac cagactgtgg atgtttacgt gaacggagac     2100

catgccgtca cgataggggg tactcagttc atattcgggc cgctgtcatc ggcctggacc     2160

ccgttcgaca acaagatagt cgtgtacaaa gacgaagtgt tcaatcagga cttcccgccg     2220

tacggatctg ggcaaccagg gcgcttcggc gacatccaaa gcagaacagt ggagagtaac     2280

gacctgtacg cgaacacggc actgaagctg gcacgccctt cacccggcat ggtccatgta     2340

ccgtacacac agacaccttc agggttcaaa tattggctaa aggaaaaagg gacagcccta     2400

aatacgaagg ctccttttgg ctgccaaatc aaaacgaacc ctgtcagggc catgaactgc     2460

gccgtgggaa acatccctgt ctccatgaat ttgcctgaca gcgcctttac ccgcattgtc     2520

gaggcgccga ccatcattga cctgacttgc acagtggcta cctgtacgca ctcctcggat     2580

ttcggcggcg tcttgacact gacgtacaag accaacaaga acggggactg ctctgtacac     2640

tcgcactcta acgtagctac tctacaggag gccacagcaa aagtgaagac agcaggtaag     2700

gtgaccttac acttctccac ggcaagcgca tcaccttctt ttgtggtgtc gctatgcagt     2760

gctagggcca cctgttcagc gtcgtgtgag cccccgaaag accacatagt cccatatgcg     2820

gctagccaca gtaacgtagt gtttccagac atgtcgggca ccgcactatc atgggtgcag     2880

aaaatctcgg gtggtctggg ggccttcgca atcggcgcta tcctggtgct ggttgtggtc     2940

acttgcattg ggctccgcag ataa                                            2964


<210>  566
<211>  987
<212>  PRT
<213>  Alphavirus Semliki Forest virus

<400>  566

Met Ser Ala Pro Leu Ile Thr Ala Met Cys Val Leu Ala Asn Ala Thr 
1               5                   10                  15      


Phe Pro Cys Phe Gln Pro Pro Cys Val Pro Cys Cys Tyr Glu Asn Asn 
            20                  25                  30          


Ala Glu Ala Thr Leu Arg Met Leu Glu Asp Asn Val Asp Arg Pro Gly 
        35                  40                  45              


Tyr Tyr Asp Leu Leu Gln Ala Ala Leu Thr Cys Arg Asn Gly Thr Arg 
    50                  55                  60                  


His Arg Arg Ser Val Ser Gln His Phe Asn Val Tyr Lys Ala Thr Arg 
65                  70                  75                  80  


Pro Tyr Ile Ala Tyr Cys Ala Asp Cys Gly Ala Gly His Ser Cys His 
                85                  90                  95      


Ser Pro Val Ala Ile Glu Ala Val Arg Ser Glu Ala Thr Asp Gly Met 
            100                 105                 110         


Leu Lys Ile Gln Phe Ser Ala Gln Ile Gly Ile Asp Lys Ser Asp Asn 
        115                 120                 125             


His Asp Tyr Thr Lys Ile Arg Tyr Ala Asp Gly His Ala Ile Glu Asn 
    130                 135                 140                 


Ala Val Arg Ser Ser Leu Lys Val Ala Thr Ser Gly Asp Cys Phe Val 
145                 150                 155                 160 


His Gly Thr Met Gly His Phe Ile Leu Ala Lys Cys Pro Pro Gly Glu 
                165                 170                 175     


Phe Leu Gln Val Ser Ile Gln Asp Thr Arg Asn Ala Val Arg Ala Cys 
            180                 185                 190         


Arg Ile Gln Tyr His His Asp Pro Gln Pro Val Gly Arg Glu Lys Phe 
        195                 200                 205             


Thr Ile Arg Pro His Tyr Gly Lys Glu Ile Pro Cys Thr Thr Tyr Gln 
    210                 215                 220                 


Gln Thr Thr Ala Glu Thr Val Glu Glu Ile Asp Met His Met Pro Pro 
225                 230                 235                 240 


Asp Thr Pro Asp Arg Thr Leu Leu Ser Gln Gln Ser Gly Asn Val Lys 
                245                 250                 255     


Ile Thr Val Gly Gly Lys Lys Val Lys Tyr Asn Cys Thr Cys Gly Thr 
            260                 265                 270         


Gly Asn Val Gly Thr Thr Asn Ser Asp Met Thr Ile Asn Thr Cys Leu 
        275                 280                 285             


Ile Glu Gln Cys His Val Ser Val Thr Asp His Lys Lys Trp Gln Phe 
    290                 295                 300                 


Asn Ser Pro Phe Val Pro Arg Ala Asp Glu Pro Ala Arg Lys Gly Lys 
305                 310                 315                 320 


Val His Ile Pro Phe Pro Leu Asp Asn Ile Thr Cys Arg Val Pro Met 
                325                 330                 335     


Ala Arg Glu Pro Thr Val Ile His Gly Lys Arg Glu Val Thr Leu His 
            340                 345                 350         


Leu His Pro Asp His Pro Thr Leu Phe Ser Tyr Arg Thr Leu Gly Glu 
        355                 360                 365             


Asp Pro Gln Tyr His Glu Glu Trp Val Thr Ala Ala Val Glu Arg Thr 
    370                 375                 380                 


Ile Pro Val Pro Val Asp Gly Met Glu Tyr His Trp Gly Asn Asn Asp 
385                 390                 395                 400 


Pro Val Arg Leu Trp Ser Gln Leu Thr Thr Glu Gly Lys Pro His Gly 
                405                 410                 415     


Trp Pro His Gln Ile Val Gln Tyr Tyr Tyr Gly Leu Tyr Pro Ala Ala 
            420                 425                 430         


Thr Val Ser Ala Val Val Gly Met Ser Leu Leu Ala Leu Ile Ser Ile 
        435                 440                 445             


Phe Ala Ser Cys Tyr Met Leu Val Ala Ala Arg Ser Lys Cys Leu Thr 
    450                 455                 460                 


Pro Tyr Ala Leu Thr Pro Gly Ala Ala Val Pro Trp Thr Leu Gly Ile 
465                 470                 475                 480 


Leu Cys Cys Ala Pro Arg Ala His Ala Ala Ser Val Ala Glu Thr Met 
                485                 490                 495     


Ala Tyr Leu Trp Asp Gln Asn Gln Ala Leu Phe Trp Leu Glu Phe Ala 
            500                 505                 510         


Ala Pro Val Ala Cys Ile Leu Ile Ile Thr Tyr Cys Leu Arg Asn Val 
        515                 520                 525             


Leu Cys Cys Cys Lys Ser Leu Ser Phe Leu Val Leu Leu Ser Leu Gly 
    530                 535                 540                 


Ala Thr Ala Arg Ala Tyr Glu His Ser Thr Val Met Pro Asn Val Val 
545                 550                 555                 560 


Gly Phe Pro Tyr Lys Ala His Ile Glu Arg Pro Gly Tyr Ser Pro Leu 
                565                 570                 575     


Thr Leu Gln Met Gln Val Val Glu Thr Ser Leu Glu Pro Thr Leu Asn 
            580                 585                 590         


Leu Glu Tyr Ile Thr Cys Glu Tyr Lys Thr Val Val Pro Ser Pro Tyr 
        595                 600                 605             


Val Lys Cys Cys Gly Ala Ser Glu Cys Ser Thr Lys Glu Lys Pro Asp 
    610                 615                 620                 


Tyr Gln Cys Lys Val Tyr Thr Gly Val Tyr Pro Phe Met Trp Gly Gly 
625                 630                 635                 640 


Ala Tyr Cys Phe Cys Asp Ser Glu Asn Thr Gln Leu Ser Glu Ala Tyr 
                645                 650                 655     


Val Asp Arg Ser Asp Val Cys Arg His Asp His Ala Ser Ala Tyr Lys 
            660                 665                 670         


Ala His Thr Ala Ser Leu Lys Ala Lys Val Arg Val Met Tyr Gly Asn 
        675                 680                 685             


Val Asn Gln Thr Val Asp Val Tyr Val Asn Gly Asp His Ala Val Thr 
    690                 695                 700                 


Ile Gly Gly Thr Gln Phe Ile Phe Gly Pro Leu Ser Ser Ala Trp Thr 
705                 710                 715                 720 


Pro Phe Asp Asn Lys Ile Val Val Tyr Lys Asp Glu Val Phe Asn Gln 
                725                 730                 735     


Asp Phe Pro Pro Tyr Gly Ser Gly Gln Pro Gly Arg Phe Gly Asp Ile 
            740                 745                 750         


Gln Ser Arg Thr Val Glu Ser Asn Asp Leu Tyr Ala Asn Thr Ala Leu 
        755                 760                 765             


Lys Leu Ala Arg Pro Ser Pro Gly Met Val His Val Pro Tyr Thr Gln 
    770                 775                 780                 


Thr Pro Ser Gly Phe Lys Tyr Trp Leu Lys Glu Lys Gly Thr Ala Leu 
785                 790                 795                 800 


Asn Thr Lys Ala Pro Phe Gly Cys Gln Ile Lys Thr Asn Pro Val Arg 
                805                 810                 815     


Ala Met Asn Cys Ala Val Gly Asn Ile Pro Val Ser Met Asn Leu Pro 
            820                 825                 830         


Asp Ser Ala Phe Thr Arg Ile Val Glu Ala Pro Thr Ile Ile Asp Leu 
        835                 840                 845             


Thr Cys Thr Val Ala Thr Cys Thr His Ser Ser Asp Phe Gly Gly Val 
    850                 855                 860                 


Leu Thr Leu Thr Tyr Lys Thr Asn Lys Asn Gly Asp Cys Ser Val His 
865                 870                 875                 880 


Ser His Ser Asn Val Ala Thr Leu Gln Glu Ala Thr Ala Lys Val Lys 
                885                 890                 895     


Thr Ala Gly Lys Val Thr Leu His Phe Ser Thr Ala Ser Ala Ser Pro 
            900                 905                 910         


Ser Phe Val Val Ser Leu Cys Ser Ala Arg Ala Thr Cys Ser Ala Ser 
        915                 920                 925             


Cys Glu Pro Pro Lys Asp His Ile Val Pro Tyr Ala Ala Ser His Ser 
    930                 935                 940                 


Asn Val Val Phe Pro Asp Met Ser Gly Thr Ala Leu Ser Trp Val Gln 
945                 950                 955                 960 


Lys Ile Ser Gly Gly Leu Gly Ala Phe Ala Ile Gly Ala Ile Leu Val 
                965                 970                 975     


Leu Val Val Val Thr Cys Ile Gly Leu Arg Arg 
            980                 985         


<210>  567
<211>  2949
<212>  DNA
<213>  Alphavirus Sindbis virus

<400>  567
atgtccgcag caccactggt cacggcaatg tgtttgctcg gaaatgtgag cttcccatgc       60

gaccgcccgc ccacatgcta tacccgcgaa ccttccagag ccctcgacat ccttgaagag      120

aacgtgaacc atgaggccta cgataccctg ctcaatgcca tattgcggtg cggatcgtct      180

ggcagaagca aaagaagcgt cattgacgac tttaccctga ccagccccta cttgggcaca      240

tgctcgtact gccaccatac tgtaccgtgc ttcagccctg ttaagatcga gcaggtctgg      300

gacgaagcgg acgataacac catacgcata cagacttccg cccagtttgg atacgaccaa      360

agcggagcag caagcgcaaa caagtaccgc tacatgtcgc ttaagcagga tcacaccgtt      420

aaagaaggca ccatggatga catcaagatt agcacctcag gaccgtgtag aaggcttagc      480

tacaaaggat actttctcct cgcaaaatgc cctccagggg acagcgtaac ggttagcata      540

gtgagtagca actcagcaac gtcatgtaca ctggcccgca agataaaacc aaaattcgtg      600

ggacgggaaa aatatgatct acctcccgtt cacggtaaaa aaattccttg cacagtgtac      660

gaccgtctga aagaaacaac tgcaggctac atcactatgc acaggccgag accgcacgct      720

tatacatcct acctggaaga atcatcaggg aaagtttacg caaagccgcc atctgggaag      780

aacattacgt atgagtgcaa gtgcggcgac tacaagaccg gaaccgtttc gacccgcacc      840

gaaatcactg gttgcaccgc catcaagcag tgcgtcgcct ataagagcga ccaaacgaag      900

tgggtcttca actcaccgga cttgatcaga catgacgacc acacggccca agggaaattg      960

catttgcctt tcaagttgat cccgagtacc tgcatggtcc ctgttgccca cgcgccgaat     1020

gtaatacatg gctttaaaca catcagcctc caattagata cagaccactt gacattgctc     1080

accaccagga gactaggggc aaacccggaa ccaaccactg aatggatcgt cggaaagacg     1140

gtcagaaact tcaccgtcga ccgagatggc ctggaataca tatggggaaa tcatgagcca     1200

gtgagggtct atgcccaaga gtcagcacca ggagaccctc acggatggcc acacgaaata     1260

gtacagcatt actaccatcg ccatcctgtg tacaccatct tagccgtcgc atcagctacc     1320

gtggcgatga tgattggcgt aactgttgca gtgttatgtg cctgtaaagc gcgccgtgag     1380

tgcctgacgc catacgccct ggccccaaac gccgtaatcc caacttcgct ggcactcttg     1440

tgctgcgtta ggtcggccaa tgctgaaacg ttcaccgaga ccatgagtta cttgtggtcg     1500

aacagtcagc cgttcttctg ggtccagttg tgcatacctt tggccgcttt catcgttcta     1560

atgcgctgct gctcctgctg cctgcctttt ttagtggttg ccggcgccta cctggcgaag     1620

gtagacgcct acgaacatgc gaccactgtt ccaaatgtgc cacagatacc gtataaggca     1680

cttgttgaaa gggcagggta tgccccgctc aatttggaga tcactgtcat gtcctcggag     1740

gttttgcctt ccaccaacca agagtacatt acctgcaaat tcaccactgt ggtcccctcc     1800

ccaaaaatca aatgctgcgg ctccttggaa tgtcagccgg ccgctcatgc agactatacc     1860

tgcaaggtct tcggaggggt ctaccccttt atgtggggag gagcgcaatg tttttgcgac     1920

agtgagaaca gccagatgag tgaggcgtac gtcgaattgt cagcagattg cgcgtctgac     1980

cacgcgcagg cgattaaggt gcacactgcc gcgatgaaag taggactgcg tattgtgtac     2040

gggaacacta ccagtttcct agatgtgtac gtgaacggag tcacaccagg aacgtctaaa     2100

gacttgaaag tcatagctgg accaatttca gcatcgttta cgccattcga tcataaggtc     2160

gttatccatc gcggcctggt gtacaactat gacttcccgg aatatggagc gatgaaacca     2220

ggagcgtttg gagacattca agctacctcc ttgactagca aggatctcat cgccagcaca     2280

gacattaggc tactcaagcc ttccgccaag aacgtgcatg tcccgtacac gcaggcctca     2340

tcaggatttg agatgtggaa aaacaactca ggccgcccac tgcaggaaac cgcacctttc     2400

gggtgtaaga ttgcagtaaa tccgctccga gcggtggact gttcatacgg gaacattccc     2460

atttctattg acatcccgaa cgctgccttt atcaggacat cagatgcacc actggtctca     2520

acagtcaaat gtgaagtcag tgagtgcact tattcagcag acttcggcgg gatggccacc     2580

ctgcagtatg tatccgaccg cgaaggtcaa tgccccgtac attcgcattc gagcacagca     2640

actctccaag agtcgacagt acatgtcctg gagaaaggag cggtgacagt acactttagc     2700

accgcgagtc cacaggcgaa ctttatcgta tcgctgtgtg ggaagaagac aacatgcaat     2760

gcagaatgta aaccaccagc tgaccatatc gtgagcaccc cgcacaaaaa tgaccaagaa     2820

tttcaagccg ccatctcaaa aacatcatgg agttggctgt ttgccctttt cggcggcgcc     2880

tcgtcgctat taattatagg acttatgatt tttgcttgca gcatgatgct gactagcaca     2940

cgaagatga                                                             2949


<210>  568
<211>  982
<212>  PRT
<213>  Alphavirus Sindbis virus

<400>  568

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Glu Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  569
<211>  2946
<212>  DNA
<213>  Alphavirus Chikungunya virus

<400>  569
atgtgcctgt tggcaaacac cacgttcccc tgctcccagc ccccttgcac gccctgctgc       60

tacgaaaagg aaccggagga aaccctacgc atgcttgagg acaacgtcat gagacctggg      120

tactatcagc tgctacaagc atccttaaca tgttctcccc accgccagcg acgcagcacc      180

aaggacaact tcaatgtcta taaagccaca agaccatact tagctcactg tcccgactgt      240

ggagaagggc actcgtgcca tagtcccgta gcactagaac gcatcagaaa tgaagcgaca      300

gacgggacgc tgaaaatcca ggtctccttg caaatcggaa taaagacgga tgacagccac      360

gattggacca agctgcgtta tatggacaac cacatgccag cagacgcaga gagggcgggg      420

ctatttgtaa gaacatcagc accgtgtacg attactggga caatgggaca cttcatcctg      480

gcccgatgtc caaaagggga aactctgacg gtgggattca ctgacagtag gaagattagt      540

cactcatgta cgcacccatt tcaccacgac cctcctgtga taggtcggga aaaattccat      600

tcccgaccgc agcacggtaa agagctacct tgcagcacgt acgtgcagag caccgccgca      660

actaccgagg agatagaggt acacatgccc ccagacaccc ctgatcgcac attaatgtca      720

caacagtccg gcaacgtaaa gatcacagtc aatggccaga cggtgcggta caagtgtaat      780

tgcggtggct caaatgaagg actaacaact acagacaaag tgattaataa ctgcaaggtt      840

gatcaatgtc atgccgcggt caccaatcac aaaaagtggc agtataactc ccctctggtc      900

ccgcgtaatg ctgaacttgg ggaccgaaaa ggaaaaattc acatcccgtt tccgctggca      960

aatgtaacat gcagggtgcc taaagcaagg aaccccaccg tgacgtacgg gaaaaaccaa     1020

gtcatcatgc tactgtatcc tgaccaccca acactcctgt cctaccggaa tatgggagaa     1080

gaaccaaact atcaagaaga gtgggtgatg cataagaagg aagtcgtgct aaccgtgccg     1140

actgaagggc tcgaggtcac gtggggcaac aacgagccgt ataagtattg gccgcagtta     1200

tctacaaacg gtacagccca tggccacccg catgagataa ttctgtatta ttatgagctg     1260

taccccacta tgactgtagt agttgtgtca gtggccacgt tcatactcct gtcgatggtg     1320

ggtatggcag cggggatgtg catgtgtgca cgacgcagat gcatcacacc gtatgaactg     1380

acaccaggag ctaccgtccc tttcctgctt agcctaatat gctgcatcag aacagctaaa     1440

gcggccacat accaagaggc tgcgatatac ctgtggaacg agcagcaacc tttgttttgg     1500

ctacaagccc ttattccgct ggcagccctg attgttctat gcaactgtct gagactctta     1560

ccatgctgct gtaaaacgtt ggctttttta gccgtaatga gcgtcggtgc ccacactgtg     1620

agcgcgtacg aacacgtaac agtgatcccg aacacggtgg gagtaccgta taagactcta     1680

gtcaatagac ctggctacag ccccatggta ttggagatgg aactactgtc agtcactttg     1740

gagccaacac tatcgcttga ttacatcacg tgcgagtaca aaaccgtcat cccgtctccg     1800

tacgtgaagt gctgcggtac agcagagtgc aaggacaaaa acctacctga ctacagctgt     1860

aaggtcttca ccggcgtcta cccatttatg tggggcggcg cctactgctt ctgcgacgct     1920

gaaaacacgc agttgagcga agcacacgtg gagaagtccg aatcatgcaa aacagaattt     1980

gcatcagcat acagggctca taccgcatct gcatcagcta agctccgcgt cctttaccaa     2040

ggaaataaca tcactgtaac tgcctatgca aacggcgacc atgccgtcac agttaaggac     2100

gccaaattca ttgtggggcc aatgtcttca gcctggacac ctttcgacaa caaaattgtg     2160

gtgtacaaag gtgacgtcta taacatggac tacccgccct ttggcgcagg aagaccagga     2220

caatttggcg atatccaaag tcgcacacct gagagtaaag acgtctatgc taatacacaa     2280

ctggtactgc agagaccggc tgtgggtacg gtacacgtgc catactctca ggcaccatct     2340

ggctttaagt attggctaaa agaacgcggg gcgtcgctgc agcacacagc accatttggc     2400

tgccaaatag caacaaaccc ggtaagagcg gtgaactgcg ccgtagggaa catgcccatc     2460

tccatcgaca taccggaagc ggccttcact agggtcgtcg acgcgccctc tttaacggac     2520

atgtcgtgcg aggtaccagc ctgcacccat tcctcagact ttgggggcgt cgccattatt     2580

aaatatgcag ccagcaagaa aggcaagtgt gcggtgcatt cgatgactaa cgccgtcact     2640

attcgggaag ctgagataga agttgaaggg aattctcagc tgcaaatctc tttctcgacg     2700

gccttagcca gcgccgaatt ccgcgtacaa gtctgttcta cacaagtaca ctgtgcagcc     2760

gagtgccacc ccccgaagga ccacatagtc aactacccgg cgtcacatac caccctcggg     2820

gtccaggaca tctccgctac ggcgatgtca tgggtgcaga agatcacggg aggtgtggga     2880

ctggttgttg ctgttgccgc actgattcta atcgtggtgc tatgcgtgtc gttcagcagg     2940

cactaa                                                                2946


<210>  570
<211>  981
<212>  PRT
<213>  Alphavirus Chikungunya virus

<400>  570

Met Cys Leu Leu Ala Asn Thr Thr Phe Pro Cys Ser Gln Pro Pro Cys 
1               5                   10                  15      


Thr Pro Cys Cys Tyr Glu Lys Glu Pro Glu Glu Thr Leu Arg Met Leu 
            20                  25                  30          


Glu Asp Asn Val Met Arg Pro Gly Tyr Tyr Gln Leu Leu Gln Ala Ser 
        35                  40                  45              


Leu Thr Cys Ser Pro His Arg Gln Arg Arg Ser Thr Lys Asp Asn Phe 
    50                  55                  60                  


Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys Pro Asp Cys 
65                  70                  75                  80  


Gly Glu Gly His Ser Cys His Ser Pro Val Ala Leu Glu Arg Ile Arg 
                85                  90                  95      


Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln Val Ser Leu Gln Ile 
            100                 105                 110         


Gly Ile Lys Thr Asp Asp Ser His Asp Trp Thr Lys Leu Arg Tyr Met 
        115                 120                 125             


Asp Asn His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu Phe Val Arg 
    130                 135                 140                 


Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His Phe Ile Leu 
145                 150                 155                 160 


Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe Thr Asp Ser 
                165                 170                 175     


Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His Asp Pro Pro 
            180                 185                 190         


Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro Gln His Gly Lys Glu 
        195                 200                 205             


Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu Glu 
    210                 215                 220                 


Ile Glu Val His Met Pro Pro Asp Thr Pro Asp Arg Thr Leu Met Ser 
225                 230                 235                 240 


Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn Gly Gln Thr Val Arg 
                245                 250                 255     


Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr Thr Thr Asp 
            260                 265                 270         


Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala Ala Val Thr 
        275                 280                 285             


Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn Ala 
    290                 295                 300                 


Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro Phe Pro Leu Ala 
305                 310                 315                 320 


Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn Pro Thr Val Thr Tyr 
                325                 330                 335     


Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro Asp His Pro Thr Leu 
            340                 345                 350         


Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu Trp 
        355                 360                 365             


Val Met His Lys Lys Glu Val Val Leu Thr Val Pro Thr Glu Gly Leu 
    370                 375                 380                 


Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp Pro Gln Leu 
385                 390                 395                 400 


Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile Ile Leu Tyr 
                405                 410                 415     


Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val Val Val Val Ser Val Ala 
            420                 425                 430         


Thr Phe Ile Leu Leu Ser Met Val Gly Met Ala Ala Gly Met Cys Met 
        435                 440                 445             


Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly Ala 
    450                 455                 460                 


Thr Val Pro Phe Leu Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala Lys 
465                 470                 475                 480 


Ala Ala Thr Tyr Gln Glu Ala Ala Ile Tyr Leu Trp Asn Glu Gln Gln 
                485                 490                 495     


Pro Leu Phe Trp Leu Gln Ala Leu Ile Pro Leu Ala Ala Leu Ile Val 
            500                 505                 510         


Leu Cys Asn Cys Leu Arg Leu Leu Pro Cys Cys Cys Lys Thr Leu Ala 
        515                 520                 525             


Phe Leu Ala Val Met Ser Val Gly Ala His Thr Val Ser Ala Tyr Glu 
    530                 535                 540                 


His Val Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys Thr Leu 
545                 550                 555                 560 


Val Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu 
                565                 570                 575     


Ser Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu 
            580                 585                 590         


Tyr Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala 
        595                 600                 605             


Glu Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe Thr 
    610                 615                 620                 


Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ala 
625                 630                 635                 640 


Glu Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu Ser Cys 
                645                 650                 655     


Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser Ala Ser 
            660                 665                 670         


Ala Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala 
        675                 680                 685             


Tyr Ala Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys Phe Ile 
    690                 695                 700                 


Val Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val 
705                 710                 715                 720 


Val Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala 
                725                 730                 735     


Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu Ser 
            740                 745                 750         


Lys Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala Val 
        755                 760                 765             


Gly Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys Tyr 
    770                 775                 780                 


Trp Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly 
                805                 810                 815     


Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg Val 
            820                 825                 830         


Val Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro Ala Cys 
        835                 840                 845             


Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr Ala Ala 
    850                 855                 860                 


Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala Val Thr 
865                 870                 875                 880 


Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu Gln Ile 
                885                 890                 895     


Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln Val Cys 
            900                 905                 910         


Ser Thr Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys Asp His 
        915                 920                 925             


Ile Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln Asp Ile 
    930                 935                 940                 


Ser Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr Gly Gly Val Gly 
945                 950                 955                 960 


Leu Val Val Ala Val Ala Ala Leu Ile Leu Ile Val Val Leu Cys Val 
                965                 970                 975     


Ser Phe Ser Arg His 
            980     


<210>  571
<211>  1509
<212>  DNA
<213>  Bornavirus Borna disease virus 1

<400>  571
atgcagctga gcatgagcag cctgatcggc ttcggcaccc tggtgctggc cctgagcgcc       60

cagaccttcg acctgcaggg cctgagctgc aacaccgaca gcacccccgg cctgatcgac      120

ctggagatca ggaggctgtg ccacaccccc accgagaacg tgatcagctg cgaggtgagc      180

tacctgaacc acaccaccat cagcctgccc gccgtgcaca ccagctgcct gaagtaccac      240

tgcaagacct actggggctt cttcggcagc tacagcgccg acaggatcat caacaggtac      300

accggcaccg tgaagggctg cctgaacaac agcgcccccg aggacccctt cgagtgcaac      360

tggttctact gctgcagcgc catcaccacc gagatctgca ggtgcagcat caccaacgtg      420

accgtggccg tgcagacctt cccccccttc atgtactgca gcttcgccga ctgcagcacc      480

gtgagccagc aggagctgga gagcggcaag gccatgctga gcgacggcag caccctgacc      540

tacaccccct acatcctgca gagcgaggtg gtgaacaaga ccctgaacgg caccatcctg      600

tgcaacagca gcagcaagat cgtgagcttc gacgagttca ggaggagcta cagcctggcc      660

aacggcagct accagagcag cagcatcaac gtgacctgcg tgaactacac cagcagctgc      720

aggagcaagc tgaggaggag gaggagggac acccagcaga tcgagtacct ggtgcacaag      780

ctgaggccca ccctgaagga cgcctgggag gactgcgaga tcctgcagag cctgctgctg      840

ggcgtgttcg gcaccggcat cgccagcgcc agccagttcc tgaggggctg gctgaaccac      900

cccgacatca tcggctacat cgtgaacggc gtgggcgtgg tgtggcagtg ccacagggtg      960

aacgtgacct tcatggcctg gaacgagagc acctactacc cccccgtgga ctacaacggc     1020

aggaagtact tcctgaacga cgagggcagg ctgcagacca acacccccga ggccaggccc     1080

ggcctgaaga gggtgatgtg gttcggcagg tacttcctgg gcaccgtggg cagcggcgtg     1140

aagcccagga ggatcaggta caacaagacc agccacgact accacctgga ggagttcgag     1200

gccagcctga acatgacccc ccagaccagc atcgccagcg gccacgagac cgaccccatc     1260

aaccacgcct acggcaccca ggccgacctg ctgccctaca ccaggagcag caacatcacc     1320

agcaccgaca ccggcagcgg ctgggtgcac atcggcctgc ccagcttcgc cttcctgaac     1380

cccctgggct ggctgaggga cctgctggcc tgggccgcct ggctgggcgg cgtgctgtac     1440

ctgatcagcc tgtgcgtgag cctgcccgcc agcttcgcca ggaggaggag gctgggcagg     1500

tggcaggag                                                             1509


<210>  572
<211>  503
<212>  PRT
<213>  Bornavirus Borna disease virus 1

<400>  572

Met Gln Leu Ser Met Ser Ser Leu Ile Gly Phe Gly Thr Leu Val Leu 
1               5                   10                  15      


Ala Leu Ser Ala Gln Thr Phe Asp Leu Gln Gly Leu Ser Cys Asn Thr 
            20                  25                  30          


Asp Ser Thr Pro Gly Leu Ile Asp Leu Glu Ile Arg Arg Leu Cys His 
        35                  40                  45              


Thr Pro Thr Glu Asn Val Ile Ser Cys Glu Val Ser Tyr Leu Asn His 
    50                  55                  60                  


Thr Thr Ile Ser Leu Pro Ala Val His Thr Ser Cys Leu Lys Tyr His 
65                  70                  75                  80  


Cys Lys Thr Tyr Trp Gly Phe Phe Gly Ser Tyr Ser Ala Asp Arg Ile 
                85                  90                  95      


Ile Asn Arg Tyr Thr Gly Thr Val Lys Gly Cys Leu Asn Asn Ser Ala 
            100                 105                 110         


Pro Glu Asp Pro Phe Glu Cys Asn Trp Phe Tyr Cys Cys Ser Ala Ile 
        115                 120                 125             


Thr Thr Glu Ile Cys Arg Cys Ser Ile Thr Asn Val Thr Val Ala Val 
    130                 135                 140                 


Gln Thr Phe Pro Pro Phe Met Tyr Cys Ser Phe Ala Asp Cys Ser Thr 
145                 150                 155                 160 


Val Ser Gln Gln Glu Leu Glu Ser Gly Lys Ala Met Leu Ser Asp Gly 
                165                 170                 175     


Ser Thr Leu Thr Tyr Thr Pro Tyr Ile Leu Gln Ser Glu Val Val Asn 
            180                 185                 190         


Lys Thr Leu Asn Gly Thr Ile Leu Cys Asn Ser Ser Ser Lys Ile Val 
        195                 200                 205             


Ser Phe Asp Glu Phe Arg Arg Ser Tyr Ser Leu Ala Asn Gly Ser Tyr 
    210                 215                 220                 


Gln Ser Ser Ser Ile Asn Val Thr Cys Val Asn Tyr Thr Ser Ser Cys 
225                 230                 235                 240 


Arg Ser Lys Leu Arg Arg Arg Arg Arg Asp Thr Gln Gln Ile Glu Tyr 
                245                 250                 255     


Leu Val His Lys Leu Arg Pro Thr Leu Lys Asp Ala Trp Glu Asp Cys 
            260                 265                 270         


Glu Ile Leu Gln Ser Leu Leu Leu Gly Val Phe Gly Thr Gly Ile Ala 
        275                 280                 285             


Ser Ala Ser Gln Phe Leu Arg Gly Trp Leu Asn His Pro Asp Ile Ile 
    290                 295                 300                 


Gly Tyr Ile Val Asn Gly Val Gly Val Val Trp Gln Cys His Arg Val 
305                 310                 315                 320 


Asn Val Thr Phe Met Ala Trp Asn Glu Ser Thr Tyr Tyr Pro Pro Val 
                325                 330                 335     


Asp Tyr Asn Gly Arg Lys Tyr Phe Leu Asn Asp Glu Gly Arg Leu Gln 
            340                 345                 350         


Thr Asn Thr Pro Glu Ala Arg Pro Gly Leu Lys Arg Val Met Trp Phe 
        355                 360                 365             


Gly Arg Tyr Phe Leu Gly Thr Val Gly Ser Gly Val Lys Pro Arg Arg 
    370                 375                 380                 


Ile Arg Tyr Asn Lys Thr Ser His Asp Tyr His Leu Glu Glu Phe Glu 
385                 390                 395                 400 


Ala Ser Leu Asn Met Thr Pro Gln Thr Ser Ile Ala Ser Gly His Glu 
                405                 410                 415     


Thr Asp Pro Ile Asn His Ala Tyr Gly Thr Gln Ala Asp Leu Leu Pro 
            420                 425                 430         


Tyr Thr Arg Ser Ser Asn Ile Thr Ser Thr Asp Thr Gly Ser Gly Trp 
        435                 440                 445             


Val His Ile Gly Leu Pro Ser Phe Ala Phe Leu Asn Pro Leu Gly Trp 
    450                 455                 460                 


Leu Arg Asp Leu Leu Ala Trp Ala Ala Trp Leu Gly Gly Val Leu Tyr 
465                 470                 475                 480 


Leu Ile Ser Leu Cys Val Ser Leu Pro Ala Ser Phe Ala Arg Arg Arg 
                485                 490                 495     


Arg Leu Gly Arg Trp Gln Glu 
            500             


<210>  573
<211>  1488
<212>  DNA
<213>  Flavivirus Tick-borne encephalitis virus

<400>  573
agcaggtgca cccacctgga gaacagggac ttcgtgaccg gcacccaggg caccaccagg       60

gtgaccctgg tgctggagct gggcggctgc gtgaccatca ccgccgaggg caagcccagc      120

atggacgtgt ggctggacgc catctaccag gagaaccccg cccagaccag ggagtactgc      180

ctgcacgcca agctgagcga caccaaggtg gccgccaggt gccccaccat gggccccgcc      240

accctggccg aggagcacca gggcggcacc gtgtgcaaga gggaccagag cgacaggggc      300

tggggcaacc actgcggcct gttcggcaag ggcagcatcg tggcctgcgt gaaggccgcc      360

tgcgaggcca agaagaaggc caccggccac gtgtacgacg ccaacaagat cgtgtacacc      420

gtgaaggtgg agccccacac cggcgactac gtggccgcca acgagaccca cagcggcagg      480

aagaccgcca gcttcaccgt gagcagcgag aagaccatcc tgaccatggg cgagtacggc      540

gacgtgagcc tgctgtgcag ggtggccagc ggcgtggacc tggcccagac cgtgatcctg      600

gagctggaca agaccgtgga gcacctgccc accgcctggc aggtgcacag ggactggttc      660

aacgacctgg ccctgccctg gaagcacgag ggcgccagga actggaacaa cgccgagagg      720

ctggtggagt tcggcgcccc ccacgccgtg aagatggacg tgtacaacct gggcgaccag      780

accggcgtgc tgctgaaggc cctggccggc gtgcccgtgg cccacatcga gggcaccaag      840

taccacctga agagcggcca cgtgacctgc gaggtgggcc tggagaagct gaagatgaag      900

ggcctgacct acaccatgtg cgacaagacc aagttcacct ggaagagggc ccccaccgac      960

agcggccacg acaccgtggt gatggaggtg accttcagcg gcaccaagcc ctgcaggatc     1020

cccgtgaggg ccgtggccca cggcagcccc gacgtgaacg tggccatgct gatcaccccc     1080

aaccccacca tcgagaacaa cggcggcggc ttcatcgaga tgcagctgcc ccccggcgac     1140

aacatcatct acgtgggcga gctgagctac cagtggttcc agaagggcag cagcatcggc     1200

agggtgttcc agaagaccaa gaagggcatc gagaggctga ccgtgatcgg cgagcacgcc     1260

tgggacttcg gcagcgccgg cggcttcctg agcagcatcg gcaaggccct gcacaccgtg     1320

ctgggcggcg ccttcaacag catcttcggc ggcgtgggct tcctgcccaa gctgctgctg     1380

ggcgtggccc tggcctggct gggcctgaac atgaggaacc ccaccatgag catgagcttc     1440

ctgctggccg gcgtgctggt gctggccatg accctgggcg tgggcgcc                  1488


<210>  574
<211>  496
<212>  PRT
<213>  Flavivirus Tick-borne encephalitis virus

<400>  574

Ser Arg Cys Thr His Leu Glu Asn Arg Asp Phe Val Thr Gly Thr Gln 
1               5                   10                  15      


Gly Thr Thr Arg Val Thr Leu Val Leu Glu Leu Gly Gly Cys Val Thr 
            20                  25                  30          


Ile Thr Ala Glu Gly Lys Pro Ser Met Asp Val Trp Leu Asp Ala Ile 
        35                  40                  45              


Tyr Gln Glu Asn Pro Ala Gln Thr Arg Glu Tyr Cys Leu His Ala Lys 
    50                  55                  60                  


Leu Ser Asp Thr Lys Val Ala Ala Arg Cys Pro Thr Met Gly Pro Ala 
65                  70                  75                  80  


Thr Leu Ala Glu Glu His Gln Gly Gly Thr Val Cys Lys Arg Asp Gln 
                85                  90                  95      


Ser Asp Arg Gly Trp Gly Asn His Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Ala Cys Val Lys Ala Ala Cys Glu Ala Lys Lys Lys Ala Thr 
        115                 120                 125             


Gly His Val Tyr Asp Ala Asn Lys Ile Val Tyr Thr Val Lys Val Glu 
    130                 135                 140                 


Pro His Thr Gly Asp Tyr Val Ala Ala Asn Glu Thr His Ser Gly Arg 
145                 150                 155                 160 


Lys Thr Ala Ser Phe Thr Val Ser Ser Glu Lys Thr Ile Leu Thr Met 
                165                 170                 175     


Gly Glu Tyr Gly Asp Val Ser Leu Leu Cys Arg Val Ala Ser Gly Val 
            180                 185                 190         


Asp Leu Ala Gln Thr Val Ile Leu Glu Leu Asp Lys Thr Val Glu His 
        195                 200                 205             


Leu Pro Thr Ala Trp Gln Val His Arg Asp Trp Phe Asn Asp Leu Ala 
    210                 215                 220                 


Leu Pro Trp Lys His Glu Gly Ala Arg Asn Trp Asn Asn Ala Glu Arg 
225                 230                 235                 240 


Leu Val Glu Phe Gly Ala Pro His Ala Val Lys Met Asp Val Tyr Asn 
                245                 250                 255     


Leu Gly Asp Gln Thr Gly Val Leu Leu Lys Ala Leu Ala Gly Val Pro 
            260                 265                 270         


Val Ala His Ile Glu Gly Thr Lys Tyr His Leu Lys Ser Gly His Val 
        275                 280                 285             


Thr Cys Glu Val Gly Leu Glu Lys Leu Lys Met Lys Gly Leu Thr Tyr 
    290                 295                 300                 


Thr Met Cys Asp Lys Thr Lys Phe Thr Trp Lys Arg Ala Pro Thr Asp 
305                 310                 315                 320 


Ser Gly His Asp Thr Val Val Met Glu Val Thr Phe Ser Gly Thr Lys 
                325                 330                 335     


Pro Cys Arg Ile Pro Val Arg Ala Val Ala His Gly Ser Pro Asp Val 
            340                 345                 350         


Asn Val Ala Met Leu Ile Thr Pro Asn Pro Thr Ile Glu Asn Asn Gly 
        355                 360                 365             


Gly Gly Phe Ile Glu Met Gln Leu Pro Pro Gly Asp Asn Ile Ile Tyr 
    370                 375                 380                 


Val Gly Glu Leu Ser Tyr Gln Trp Phe Gln Lys Gly Ser Ser Ile Gly 
385                 390                 395                 400 


Arg Val Phe Gln Lys Thr Lys Lys Gly Ile Glu Arg Leu Thr Val Ile 
                405                 410                 415     


Gly Glu His Ala Trp Asp Phe Gly Ser Ala Gly Gly Phe Leu Ser Ser 
            420                 425                 430         


Ile Gly Lys Ala Leu His Thr Val Leu Gly Gly Ala Phe Asn Ser Ile 
        435                 440                 445             


Phe Gly Gly Val Gly Phe Leu Pro Lys Leu Leu Leu Gly Val Ala Leu 
    450                 455                 460                 


Ala Trp Leu Gly Leu Asn Met Arg Asn Pro Thr Met Ser Met Ser Phe 
465                 470                 475                 480 


Leu Leu Ala Gly Val Leu Val Leu Ala Met Thr Leu Gly Val Gly Ala 
                485                 490                 495     


<210>  575
<211>  1836
<212>  DNA
<213>  Flavivirus Usutu virus

<400>  575
agcaccgtga gcaactgccc caccaccggc gaggcccaca accccaagag ggccgaggac       60

acctacgtgt gcaagagcgg cgtgaccgac aggggctggg gcaacggctg cggcctgttc      120

ggcaagggca gcatcgacac ctgcgccaac ttcacctgca gcctgaaggc catgggcagg      180

atgatccagc ccgagaacgt gaagtacgag gtgggcatct tcatccacgg cagcaccagc      240

agcgacaccc acggcaacta cagcagccag ctgggcgcca gccaggccgg caggttcacc      300

atcaccccca acagccccgc catcaccgtg aagatgggcg actacggcga gatcagcgtg      360

gagtgcgagc ccaggaacgg cctgaacacc gaggcctact acatcatgag cgtgggcacc      420

aagcacttcc tggtgcacag ggagtggttc aacgacctgg ccctgccctg gaccagcccc      480

gccagcagca actggaggaa cagggagatc ctgctggagt tcgaggagcc ccacgccacc      540

aagcagagcg tggtggccct gggcagccag gagggcgccc tgcaccaggc cctggccggc      600

gccgtgcccg tgagcttcag cggcagcgtg aagctgacca gcggccacct gaagtgcagg      660

gtgaagatgg agaagctgac cctgaagggc accacctacg gcatgtgcac cgagaagttc      720

agcttcgcca agaaccccgc cgacaccggc cacggcaccg tggtgctgga gctgcagtac      780

accggcagcg acggcccctg caagatcccc atcagcatcg tggccagcct gagcgacctg      840

acccccatcg gcaggatggt gaccgccaac ccctacgtgg ccagcagcga ggccaacgcc      900

aaggtgctgg tggagatgga gccccccttc ggcgacagct acatcgtggt gggcaggggc      960

gacaagcaga tcaaccacca ctggcacaag gccggcagca gcatcggcaa ggccttcatc     1020

accaccatca agggcgccca gaggctggcc gccctgggcg acaccgcctg ggacttcggc     1080

agcgtgggcg gcatcttcaa cagcgtgggc aaggccgtgc accaggtgtt cggcggcgcc     1140

ttcaggaccc tgttcggcgg catgagctgg atcacccagg gcctgatggg cgccctgctg     1200

ctgtggatgg gcgtgaacgc cagggacagg agcatcgccc tggtgatgct ggccaccggc     1260

ggcgtgctgc tgttcctggc caccaacgtg cacgccgaca gcggctgcgc catcgacgtg     1320

ggcaggaggg agctgaggtg cggccagggc atcttcatcc acaacgacgt ggaggcctgg     1380

gtggacaggt acaagttcat gcccgagacc cccaagcagc tggccaaggt gatcgagcag     1440

gcccacgcca agggcatctg cggcctgagg agcgtgagca ggctggagca cgtgatgtgg     1500

gagaacatca gggacgagct gaacaccctg ctgagggaga acgccgtgga cctgagcgtg     1560

gtggtggaga agcccaaggg catgtacaag agcgcccccc agaggctggc cctgaccagc     1620

gaggagttcg agatcggctg gaaggcctgg ggcaagagcc tggtgttcgc ccccgagctg     1680

gccaaccaca ccttcgtggt ggacggcccc gagaccaagg agtgccccga cgccaagagg     1740

gcctggaaca gcctggagat cgaggacttc ggcttcggca tcatgagcac cagggtgtgg     1800

ctgaaggtga gggagcacaa caccaccgac tgcgac                               1836


<210>  576
<211>  612
<212>  PRT
<213>  Flavivirus Usutu virus

<400>  576

Ser Thr Val Ser Asn Cys Pro Thr Thr Gly Glu Ala His Asn Pro Lys 
1               5                   10                  15      


Arg Ala Glu Asp Thr Tyr Val Cys Lys Ser Gly Val Thr Asp Arg Gly 
            20                  25                  30          


Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Ile Asp Thr Cys 
        35                  40                  45              


Ala Asn Phe Thr Cys Ser Leu Lys Ala Met Gly Arg Met Ile Gln Pro 
    50                  55                  60                  


Glu Asn Val Lys Tyr Glu Val Gly Ile Phe Ile His Gly Ser Thr Ser 
65                  70                  75                  80  


Ser Asp Thr His Gly Asn Tyr Ser Ser Gln Leu Gly Ala Ser Gln Ala 
                85                  90                  95      


Gly Arg Phe Thr Ile Thr Pro Asn Ser Pro Ala Ile Thr Val Lys Met 
            100                 105                 110         


Gly Asp Tyr Gly Glu Ile Ser Val Glu Cys Glu Pro Arg Asn Gly Leu 
        115                 120                 125             


Asn Thr Glu Ala Tyr Tyr Ile Met Ser Val Gly Thr Lys His Phe Leu 
    130                 135                 140                 


Val His Arg Glu Trp Phe Asn Asp Leu Ala Leu Pro Trp Thr Ser Pro 
145                 150                 155                 160 


Ala Ser Ser Asn Trp Arg Asn Arg Glu Ile Leu Leu Glu Phe Glu Glu 
                165                 170                 175     


Pro His Ala Thr Lys Gln Ser Val Val Ala Leu Gly Ser Gln Glu Gly 
            180                 185                 190         


Ala Leu His Gln Ala Leu Ala Gly Ala Val Pro Val Ser Phe Ser Gly 
        195                 200                 205             


Ser Val Lys Leu Thr Ser Gly His Leu Lys Cys Arg Val Lys Met Glu 
    210                 215                 220                 


Lys Leu Thr Leu Lys Gly Thr Thr Tyr Gly Met Cys Thr Glu Lys Phe 
225                 230                 235                 240 


Ser Phe Ala Lys Asn Pro Ala Asp Thr Gly His Gly Thr Val Val Leu 
                245                 250                 255     


Glu Leu Gln Tyr Thr Gly Ser Asp Gly Pro Cys Lys Ile Pro Ile Ser 
            260                 265                 270         


Ile Val Ala Ser Leu Ser Asp Leu Thr Pro Ile Gly Arg Met Val Thr 
        275                 280                 285             


Ala Asn Pro Tyr Val Ala Ser Ser Glu Ala Asn Ala Lys Val Leu Val 
    290                 295                 300                 


Glu Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg Gly 
305                 310                 315                 320 


Asp Lys Gln Ile Asn His His Trp His Lys Ala Gly Ser Ser Ile Gly 
                325                 330                 335     


Lys Ala Phe Ile Thr Thr Ile Lys Gly Ala Gln Arg Leu Ala Ala Leu 
            340                 345                 350         


Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Ile Phe Asn Ser 
        355                 360                 365             


Val Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr Leu 
    370                 375                 380                 


Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Met Gly Ala Leu Leu 
385                 390                 395                 400 


Leu Trp Met Gly Val Asn Ala Arg Asp Arg Ser Ile Ala Leu Val Met 
                405                 410                 415     


Leu Ala Thr Gly Gly Val Leu Leu Phe Leu Ala Thr Asn Val His Ala 
            420                 425                 430         


Asp Ser Gly Cys Ala Ile Asp Val Gly Arg Arg Glu Leu Arg Cys Gly 
        435                 440                 445             


Gln Gly Ile Phe Ile His Asn Asp Val Glu Ala Trp Val Asp Arg Tyr 
    450                 455                 460                 


Lys Phe Met Pro Glu Thr Pro Lys Gln Leu Ala Lys Val Ile Glu Gln 
465                 470                 475                 480 


Ala His Ala Lys Gly Ile Cys Gly Leu Arg Ser Val Ser Arg Leu Glu 
                485                 490                 495     


His Val Met Trp Glu Asn Ile Arg Asp Glu Leu Asn Thr Leu Leu Arg 
            500                 505                 510         


Glu Asn Ala Val Asp Leu Ser Val Val Val Glu Lys Pro Lys Gly Met 
        515                 520                 525             


Tyr Lys Ser Ala Pro Gln Arg Leu Ala Leu Thr Ser Glu Glu Phe Glu 
    530                 535                 540                 


Ile Gly Trp Lys Ala Trp Gly Lys Ser Leu Val Phe Ala Pro Glu Leu 
545                 550                 555                 560 


Ala Asn His Thr Phe Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro 
                565                 570                 575     


Asp Ala Lys Arg Ala Trp Asn Ser Leu Glu Ile Glu Asp Phe Gly Phe 
            580                 585                 590         


Gly Ile Met Ser Thr Arg Val Trp Leu Lys Val Arg Glu His Asn Thr 
        595                 600                 605             


Thr Asp Cys Asp 
    610         


<210>  577
<211>  1503
<212>  DNA
<213>  Flavivirus St. Louis encephalitis virus

<400>  577
ttcaactgcc tgggcaccag caacagggac ttcgtggagg gcgccagcgg cgccacctgg       60

atcgacctgg tgctggaggg cggcagctgc gtgaccgtga tggcccccga gaagcccacc      120

ctggacttca aggtgatgaa gatggaggcc accgagctgg ccaccgtgag ggagtactgc      180

tacgaggcca ccctggacac cctgagcacc gtggccaggt gccccaccac cggcgaggcc      240

cacaacacca agaggagcga ccccaccttc gtgtgcaaga gggacgtggt ggacaggggc      300

tggggcaacg gctgcggcct gttcggcaag ggcagcatcg acacctgcgc caagttcacc      360

tgcaagagca aggccaccgg caagaccatc ctgagggaga acatcaagta cgaggtggcc      420

atcttcgtgc acggcagcac cgacagcacc acccacggca actacttcga gcagatcggc      480

aagaaccagg ccgccaggtt caccatcagc ccccaggccc ccagcttcac cgccaacatg      540

ggcgagtacg gcaccgtgac catcgactgc gaggccagga gcggcatcaa caccgaggac      600

tactacgtgt tcaccgtgaa ggagaagagc tggctggtga acagggactg gttccacgac      660

ctgaacctgc cctggaccag ccccgccacc accgactgga ggaacaggga gaccctggtg      720

gagttcgagg agccccacgc caccaagcag accgtggtgg ccctgggcag ccaggagggc      780

gccctgcaca ccgccctggc cggcgccatc cccgccaccg tgagcagcag caccctgacc      840

ctgcagagcg gccacctgaa gtgcagggcc aagctggaca aggtgaagat caagggcacc      900

acctacggca tgtgcgacag cgccttcacc ttcagcaaga accccgccga caccggccac      960

ggcaccgtga tcgtggagct gcagtacacc ggcagcaacg gcccctgcag ggtgcccatc     1020

agcgtgaccg ccaacctgat ggacctgacc cccgtgggca ggctggtgac cgtgaacccc     1080

ttcatcagca ccggcggcgc caacaacaag gtgatggtgg aggtggagcc ccccttcggc     1140

gacagctaca tcgtggtggg caggggcacc acccagatca actaccactg gcacaaggag     1200

ggcagcagca tcggcaaggc cctggccacc acctggaagg gcgcccagag gctggccgtg     1260

ctgggcgaca ccgcctggga cttcggcagc atcggcggcg tgttcaacag catcggcaag     1320

gccgtgcacc aggtgttcgg cggcgccttc aggaccctgt tcggcggcat gagctggatc     1380

acccagggcc tgctgggcgc cctgctgctg tggatgggcc tgcaggccag ggacaggagc     1440

atcagcctga ccctgctggc cgtgggcggc atcctgatct tcctggccac cagcgtgcag     1500

gcc                                                                   1503


<210>  578
<211>  501
<212>  PRT
<213>  Flavivirus St. Louis encephalitis virus

<400>  578

Phe Asn Cys Leu Gly Thr Ser Asn Arg Asp Phe Val Glu Gly Ala Ser 
1               5                   10                  15      


Gly Ala Thr Trp Ile Asp Leu Val Leu Glu Gly Gly Ser Cys Val Thr 
            20                  25                  30          


Val Met Ala Pro Glu Lys Pro Thr Leu Asp Phe Lys Val Met Lys Met 
        35                  40                  45              


Glu Ala Thr Glu Leu Ala Thr Val Arg Glu Tyr Cys Tyr Glu Ala Thr 
    50                  55                  60                  


Leu Asp Thr Leu Ser Thr Val Ala Arg Cys Pro Thr Thr Gly Glu Ala 
65                  70                  75                  80  


His Asn Thr Lys Arg Ser Asp Pro Thr Phe Val Cys Lys Arg Asp Val 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Asp Thr Cys Ala Lys Phe Thr Cys Lys Ser Lys Ala Thr Gly Lys 
        115                 120                 125             


Thr Ile Leu Arg Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe Val His 
    130                 135                 140                 


Gly Ser Thr Asp Ser Thr Thr His Gly Asn Tyr Phe Glu Gln Ile Gly 
145                 150                 155                 160 


Lys Asn Gln Ala Ala Arg Phe Thr Ile Ser Pro Gln Ala Pro Ser Phe 
                165                 170                 175     


Thr Ala Asn Met Gly Glu Tyr Gly Thr Val Thr Ile Asp Cys Glu Ala 
            180                 185                 190         


Arg Ser Gly Ile Asn Thr Glu Asp Tyr Tyr Val Phe Thr Val Lys Glu 
        195                 200                 205             


Lys Ser Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Asn Leu Pro 
    210                 215                 220                 


Trp Thr Ser Pro Ala Thr Thr Asp Trp Arg Asn Arg Glu Thr Leu Val 
225                 230                 235                 240 


Glu Phe Glu Glu Pro His Ala Thr Lys Gln Thr Val Val Ala Leu Gly 
                245                 250                 255     


Ser Gln Glu Gly Ala Leu His Thr Ala Leu Ala Gly Ala Ile Pro Ala 
            260                 265                 270         


Thr Val Ser Ser Ser Thr Leu Thr Leu Gln Ser Gly His Leu Lys Cys 
        275                 280                 285             


Arg Ala Lys Leu Asp Lys Val Lys Ile Lys Gly Thr Thr Tyr Gly Met 
    290                 295                 300                 


Cys Asp Ser Ala Phe Thr Phe Ser Lys Asn Pro Ala Asp Thr Gly His 
305                 310                 315                 320 


Gly Thr Val Ile Val Glu Leu Gln Tyr Thr Gly Ser Asn Gly Pro Cys 
                325                 330                 335     


Arg Val Pro Ile Ser Val Thr Ala Asn Leu Met Asp Leu Thr Pro Val 
            340                 345                 350         


Gly Arg Leu Val Thr Val Asn Pro Phe Ile Ser Thr Gly Gly Ala Asn 
        355                 360                 365             


Asn Lys Val Met Val Glu Val Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 


Val Val Gly Arg Gly Thr Thr Gln Ile Asn Tyr His Trp His Lys Glu 
385                 390                 395                 400 


Gly Ser Ser Ile Gly Lys Ala Leu Ala Thr Thr Trp Lys Gly Ala Gln 
                405                 410                 415     


Arg Leu Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly 
            420                 425                 430         


Gly Val Phe Asn Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly 
        435                 440                 445             


Ala Phe Arg Thr Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu 
    450                 455                 460                 


Leu Gly Ala Leu Leu Leu Trp Met Gly Leu Gln Ala Arg Asp Arg Ser 
465                 470                 475                 480 


Ile Ser Leu Thr Leu Leu Ala Val Gly Gly Ile Leu Ile Phe Leu Ala 
                485                 490                 495     


Thr Ser Val Gln Ala 
            500     


<210>  579
<211>  1416
<212>  DNA
<213>  Flavivirus Yellow fever virus

<400>  579
gtgggccccg cctacagcgc ccactgcatc ggcatcaccg acagggactt catcgagggc       60

gtgcacggcg gcacctgggt gagcgccacc ctggagcagg acaagtgcgt gaccgtgatg      120

gcccccgaca agcccagcct ggacatcagc ctggagaccg tggccatcga caggcccgcc      180

gaggtgagga aggtgtgcta caacgccgtg ctgacccacg tgaagatcaa cgacaagtgc      240

cccagcaccg gcgaggccca cctggccgag gagaacgagg gcgacaacgc ctgcaagagg      300

acctacagcg acaggggctg gggcaacggc tgcggcctgt tcggcaaggg cagcatcgtg      360

gcctgcgcca agttcacctg cgccaagagc atgagcctgt tcgaggtgga ccagaccaag      420

atccagtacg tgatcagggc ccagctgcac gtgggcgcca agcaggagaa ctggaacacc      480

gacatcaaga ccctgaagtt cgacgccctg agcggcagcc aggaggtgga gttcatcggc      540

tacggcaagg ccaccctgga gtgccaggtg cagaccgccg tggacttcgg caacagctac      600

atcgccgaga tggagaccga gagctggatc gtggacaggc agtgggccca ggacctgacc      660

ctgccctggc agagcggcag cggcggcgtg tggagggaga tgcaccacct ggtggagttc      720

gagccccccc acgccgccac catcagggtg ctggccctgg gcaaccagga gggcagcctg      780

aagaccgccc tgaccggcgc catgagggtg accaaggaca ccaacgacaa caacctgtac      840

aagctgcacg gcggccacgt gagctgcagg gtgaagctga gcgccctgac cctgaagggc      900

accagctaca agatctgcac cgacaagatg ttcttcgtga agaaccccac cgacaccggc      960

cacggcaccg tggtgatgca ggtgaaggtg agcaagggcg ccccctgcag gatccccgtg     1020

atcgtggccg acgacctgac cgccgccatc aacaagggca tcctggtgac cgtgaacccc     1080

atcgccagca ccaacgacga cgaggtgctg atcgaggtga accccccctt cggcgacagc     1140

tacatcatcg tgggcagggg cgacagcagg ctgacctacc agtggcacaa ggagggcagc     1200

agcatcggca agctgttcac ccagaccatg aagggcgtgg agaggctggc cgtgatgggc     1260

gacaccgcct gggacttcag cagcgccggc ggcttcttca ccagcgtggg caagggcatc     1320

cacaccgtgt tcggcagcgc cttccagggc ctgttcggcg gcctgaactg gatcaccaag     1380

gtgatcatgg gcgccgtgct gatctgggtg ggcatc                               1416


<210>  580
<211>  472
<212>  PRT
<213>  Flavivirus Yellow fever virus

<400>  580

Val Gly Pro Ala Tyr Ser Ala His Cys Ile Gly Ile Thr Asp Arg Asp 
1               5                   10                  15      


Phe Ile Glu Gly Val His Gly Gly Thr Trp Val Ser Ala Thr Leu Glu 
            20                  25                  30          


Gln Asp Lys Cys Val Thr Val Met Ala Pro Asp Lys Pro Ser Leu Asp 
        35                  40                  45              


Ile Ser Leu Glu Thr Val Ala Ile Asp Arg Pro Ala Glu Val Arg Lys 
    50                  55                  60                  


Val Cys Tyr Asn Ala Val Leu Thr His Val Lys Ile Asn Asp Lys Cys 
65                  70                  75                  80  


Pro Ser Thr Gly Glu Ala His Leu Ala Glu Glu Asn Glu Gly Asp Asn 
                85                  90                  95      


Ala Cys Lys Arg Thr Tyr Ser Asp Arg Gly Trp Gly Asn Gly Cys Gly 
            100                 105                 110         


Leu Phe Gly Lys Gly Ser Ile Val Ala Cys Ala Lys Phe Thr Cys Ala 
        115                 120                 125             


Lys Ser Met Ser Leu Phe Glu Val Asp Gln Thr Lys Ile Gln Tyr Val 
    130                 135                 140                 


Ile Arg Ala Gln Leu His Val Gly Ala Lys Gln Glu Asn Trp Asn Thr 
145                 150                 155                 160 


Asp Ile Lys Thr Leu Lys Phe Asp Ala Leu Ser Gly Ser Gln Glu Val 
                165                 170                 175     


Glu Phe Ile Gly Tyr Gly Lys Ala Thr Leu Glu Cys Gln Val Gln Thr 
            180                 185                 190         


Ala Val Asp Phe Gly Asn Ser Tyr Ile Ala Glu Met Glu Thr Glu Ser 
        195                 200                 205             


Trp Ile Val Asp Arg Gln Trp Ala Gln Asp Leu Thr Leu Pro Trp Gln 
    210                 215                 220                 


Ser Gly Ser Gly Gly Val Trp Arg Glu Met His His Leu Val Glu Phe 
225                 230                 235                 240 


Glu Pro Pro His Ala Ala Thr Ile Arg Val Leu Ala Leu Gly Asn Gln 
                245                 250                 255     


Glu Gly Ser Leu Lys Thr Ala Leu Thr Gly Ala Met Arg Val Thr Lys 
            260                 265                 270         


Asp Thr Asn Asp Asn Asn Leu Tyr Lys Leu His Gly Gly His Val Ser 
        275                 280                 285             


Cys Arg Val Lys Leu Ser Ala Leu Thr Leu Lys Gly Thr Ser Tyr Lys 
    290                 295                 300                 


Ile Cys Thr Asp Lys Met Phe Phe Val Lys Asn Pro Thr Asp Thr Gly 
305                 310                 315                 320 


His Gly Thr Val Val Met Gln Val Lys Val Ser Lys Gly Ala Pro Cys 
                325                 330                 335     


Arg Ile Pro Val Ile Val Ala Asp Asp Leu Thr Ala Ala Ile Asn Lys 
            340                 345                 350         


Gly Ile Leu Val Thr Val Asn Pro Ile Ala Ser Thr Asn Asp Asp Glu 
        355                 360                 365             


Val Leu Ile Glu Val Asn Pro Pro Phe Gly Asp Ser Tyr Ile Ile Val 
    370                 375                 380                 


Gly Arg Gly Asp Ser Arg Leu Thr Tyr Gln Trp His Lys Glu Gly Ser 
385                 390                 395                 400 


Ser Ile Gly Lys Leu Phe Thr Gln Thr Met Lys Gly Val Glu Arg Leu 
                405                 410                 415     


Ala Val Met Gly Asp Thr Ala Trp Asp Phe Ser Ser Ala Gly Gly Phe 
            420                 425                 430         


Phe Thr Ser Val Gly Lys Gly Ile His Thr Val Phe Gly Ser Ala Phe 
        435                 440                 445             


Gln Gly Leu Phe Gly Gly Leu Asn Trp Ile Thr Lys Val Ile Met Gly 
    450                 455                 460                 


Ala Val Leu Ile Trp Val Gly Ile 
465                 470         


<210>  581
<211>  1485
<212>  DNA
<213>  Flavivirus Dengue virus 2

<400>  581
atgaggtgca tcggcatcag caacagggac ttcgtggagg gcgtgagcgg cggcagctgg       60

gtggacatcg tgctggagca cggcagctgc gtgaccacca tggccaagaa caagcccacc      120

ctggacttcg agctgatcaa gaccgaggcc aagcaccccg ccaccctgag gaagtactgc      180

gtggaggcca agctgaccaa caccaccacc gccagcaggt gccccaccca gggcgagccc      240

agcctgaacg aggagcagga caagaggttc gtgtgcaagc acagcatggt ggacaggggc      300

tggggcaacg gctgcggcct gttcggcaag ggcggcatcg tgacctgcgc catgttcacc      360

tgcaagaaga acatggaggg caaggtggtg cagcccgaga acctggagta caccatcgtg      420

atcacccccc acagcggcga ggagaacgcc gtgggcaacg acaccggcaa gcacggcaag      480

gagatcaagg tgacccccca gagcagcatc accgaggccg agctgaccgg ctacggcacc      540

gtgaccatgg agtgcagccc caggaccggc ctggacttca acgagatggt gctgctgcag      600

atggagaaca aggcctggct ggtgcacagg cagtggttcc tggacctgcc cctgccctgg      660

ctgcccggcg ccgacaccca gggcagcaac tggatccaga aggagaccct ggtgaccttc      720

aagaaccccc acgccaagaa gcaggacgtg gtggtgctgg gcagccagga gggcgccatg      780

cacaccgccc tgaccggcgc caccgagatc cagatgagca gcggcaacct gctgttcacc      840

ggccacctga agtgcaggct gaggatggac aagctgcagc tgaagggcat gagctacagc      900

atgtgcaccg gcaagttcaa ggtggtgaag gagatcgccg agacccagca cggcaccatc      960

gtgatcaggg tgcagtacga gggcgacggc agcccctgca agatcccctt cgagatcatg     1020

gacctggaga agaggcacgt gctgggcagg ctgatcaccg tgaaccccat cgtgaccgag     1080

aaggacagcc ccgtgaacat cgaggccgag ccccccttcg gcgacagcta catcatcatc     1140

ggcgtggagc ccggccagct gaagctgagc tggttcaaga agggcagcag catcggccag     1200

atgttcgaga ccaccatgag gggcgccaag aggatggcca tcctgggcga caccgcctgg     1260

gacttcggca gcctgggcgg cgtgttcacc agcatcggca aggccctgca ccaggtgttc     1320

ggcgccatct acggcgccgc cttcagcggc gtgagctgga ccatgaagat cctgatcggc     1380

gtggtgatca cctggatcgg catgaacagc aggagcacca gcctgagcgt gagcctggtg     1440

ctggtgggcg tggtgaccct gtacctgggc gtgatggtgc aggcc                     1485


<210>  582
<211>  495
<212>  PRT
<213>  Flavivirus Dengue virus 2

<400>  582

Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys His Pro Ala Thr Leu Arg Lys Tyr Cys Val Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Ala Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu Asn Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Val Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Ser Trp Phe Lys Lys Gly Ser Ser Ile Gly Gln 
385                 390                 395                 400 


Met Phe Glu Thr Thr Met Arg Gly Ala Lys Arg Met Ala Ile Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr Ser Ile 
            420                 425                 430         


Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala Ala Phe 
        435                 440                 445             


Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Val Ile Thr 
    450                 455                 460                 


Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser Leu Val 
465                 470                 475                 480 


Leu Val Gly Val Val Thr Leu Tyr Leu Gly Val Met Val Gln Ala 
                485                 490                 495 


<210>  583
<211>  1479
<212>  DNA
<213>  Flavivirus Dengue virus 3

<400>  583
atgaggtgcg tgggcgtggg caacagggac ttcgtggagg gcctgagcgg cgccacctgg       60

gtggacgtgg tgctggagca cggcggctgc gtgaccacca tggccaagaa caagcccacc      120

ctggacatcg agctgcagaa gaccgaggcc acccagctgg ccaccctgag gaagctgtgc      180

atcgagggca agatcaccaa catcaccacc gacagcaggt gccccaccca gggcgaggcc      240

atcctgcccg aggagcagga ccagaactac gtgtgcaagc acacctacgt ggacaggggc      300

tggggcaacg gctgcggcct gttcggcaag ggcagcctgg tgacctgcgc caagttccag      360

tgcctggaga gcatcgaggg caaggtggtg cagcacgaga acctgaagta caccgtgatc      420

atcaccgtgc acaccggcga ccagcaccag gtgggcaacg agacccaggg cgtgaccgcc      480

gagatcacca gccaggccag caccgccgag gccatcctgc ccgagtacgg caccctgggc      540

ctggagtgca gccccaggac cggcctggac ttcaacgaga tgatcctgct gaccatgaag      600

aacaaggcct ggatggtgca caggcagtgg ttcttcgacc tgcccctgcc ctggaccagc      660

ggcgccacca ccaagacccc cacctggaac aggaaggagc tgctggtgac cttcaagaac      720

gcccacgcca agaagcagga ggtggtggtg ctgggcagcc aggagggcgc catgcacacc      780

gccctgaccg gcgccaccga gatccagacc agcggcggca ccagcatctt cgccggccac      840

ctgaagtgca ggctgaagat ggacaagctg aagctgaagg gcatgagcta cgccatgtgc      900

ctgaacacct tcgtgctgaa gaaggaggtg agcgagaccc agcacggcac catcctgatc      960

aaggtggagt acaagggcga ggacgccccc tgcaagatcc ccttcagcac cgaggacggc     1020

cagggcaagg cccacaacgg caggctgatc accgccaacc ccgtggtgac caagaaggag     1080

gagcccgtga acatcgaggc cgagcccccc ttcggcgaga gcaacatcgt gatcggcatc     1140

ggcgacaagg ccctgaagat caactggtac aggaagggca gcagcatcgg caagatgttc     1200

gaggccaccg ccaggggcgc caggaggatg gccatcctgg gcgacaccgc ctgggacttc     1260

ggcagcgtgg gcggcgtgct gaacagcctg ggcaagatgg tgcaccagat cttcggcagc     1320

gcctacaccg ccctgttcag cggcgtgagc tggatcatga agatcggcat cggcgtgctg     1380

ctgacctgga tcggcctgaa cagcaagaac accagcatga gcttcagctg catcgccatc     1440

ggcatcatca ccctgtacct gggcgtggtg gtgcaggcc                            1479


<210>  584
<211>  493
<212>  PRT
<213>  Flavivirus Dengue virus 3

<400>  584

Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr 
        35                  40                  45              


Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys 
    50                  55                  60                  


Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Ile Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly Lys 
        115                 120                 125             


Val Val Gln His Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala 
145                 150                 155                 160 


Glu Ile Thr Ser Gln Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu Tyr 
                165                 170                 175     


Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn 
            180                 185                 190         


Glu Met Ile Leu Leu Thr Met Lys Asn Lys Ala Trp Met Val His Arg 
        195                 200                 205             


Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Thr 
    210                 215                 220                 


Lys Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn 
225                 230                 235                 240 


Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly 
                245                 250                 255     


Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr Ser Gly 
            260                 265                 270         


Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp 
        275                 280                 285             


Lys Leu Lys Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Asn Thr Phe 
    290                 295                 300                 


Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile 
305                 310                 315                 320 


Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser 
                325                 330                 335     


Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala 
            340                 345                 350         


Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu 
        355                 360                 365             


Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala 
    370                 375                 380                 


Leu Lys Ile Asn Trp Tyr Arg Lys Gly Ser Ser Ile Gly Lys Met Phe 
385                 390                 395                 400 


Glu Ala Thr Ala Arg Gly Ala Arg Arg Met Ala Ile Leu Gly Asp Thr 
                405                 410                 415     


Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn Ser Leu Gly Lys 
            420                 425                 430         


Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala Leu Phe Ser Gly 
        435                 440                 445             


Val Ser Trp Ile Met Lys Ile Gly Ile Gly Val Leu Leu Thr Trp Ile 
    450                 455                 460                 


Gly Leu Asn Ser Lys Asn Thr Ser Met Ser Phe Ser Cys Ile Ala Ile 
465                 470                 475                 480 


Gly Ile Ile Thr Leu Tyr Leu Gly Val Val Val Gln Ala 
                485                 490             


<210>  585
<211>  216
<212>  DNA
<213>  Flavivirus Dengue virus 4

<400>  585
ttcggcagcg tgggcggcct gttcaccagc ctgggcaagg ccgtgcacca ggtgttcggc       60

agcgtgtaca ccaccatgtt cggcggcgtg agctggatga tcaggatcct gatcggcttc      120

ctggtgctgt ggatcggcac caacagcagg aacaccagca tggccatgac ctgcatcgcc      180

gtgggcggca tcaccctgtt cctgggcttc accgtg                                216


<210>  586
<211>  72
<212>  PRT
<213>  Flavivirus Dengue virus 4

<400>  586

Phe Gly Ser Val Gly Gly Leu Phe Thr Ser Leu Gly Lys Ala Val His 
1               5                   10                  15      


Gln Val Phe Gly Ser Val Tyr Thr Thr Met Phe Gly Gly Val Ser Trp 
            20                  25                  30          


Met Ile Arg Ile Leu Ile Gly Phe Leu Val Leu Trp Ile Gly Thr Asn 
        35                  40                  45              


Ser Arg Asn Thr Ser Met Ala Met Thr Cys Ile Ala Val Gly Gly Ile 
    50                  55                  60                  


Thr Leu Phe Leu Gly Phe Thr Val 
65                  70          


<210>  587
<211>  1503
<212>  DNA
<213>  Flavivirus Murray Valley encephalitis virus

<400>  587
ttcaactgcc tgggcatgag cagcagggac ttcatcgagg gcgccagcgg cgccacctgg       60

gtggacctgg tgctggaggg cgacagctgc atcaccatca tggccgccga caagcccacc      120

ctggacatca ggatgatgaa catcgaggcc accaacctgg ccctggtgag gaactactgc      180

tacgccgcca ccgtgagcga cgtgagcacc gtgagcaact gccccaccac cggcgagagc      240

cacaacacca agagggccga ccacaactac ctgtgcaaga ggggcgtgac cgacaggggc      300

tggggcaacg gctgcggcct gttcggcaag ggcagcatcg acacctgcgc caagttcacc      360

tgcagcaaca gcgccgccgg caggctgatc ctgcccgagg acatcaagta cgaggtgggc      420

gtgttcgtgc acggcagcac cgacagcacc agccacggca actacagcac ccagatcggc      480

gccaaccagg ccgtgaggtt caccatcagc cccaacgccc ccgccatcac cgccaagatg      540

ggcgactacg gcgaggtgac cgtggagtgc gagcccagga gcggcctgaa caccgaggcc      600

tactacgtga tgaccatcgg caccaagcac ttcctggtgc acagggagtg gttcaacgac      660

ctgctgctgc cctggaccag ccccgccagc accgagtgga ggaacaggga gatcctggtg      720

gagttcgagg agccccacgc caccaagcag agcgtggtgg ccctgggcag ccaggagggc      780

gccctgcacc aggccctggc cggcgccatc cccgtggagt tcagcagcag caccctgaag      840

ctgaccagcg gccacctgaa gtgcagggtg aagatggaga agctgaagct gaagggcacc      900

acctacggca tgtgcaccga gaagttcacc ttcagcaaga accccgccga caccggccac      960

ggcaccgtgg tgctggagct gcagtacacc ggcagcgacg gcccctgcaa gatccccatc     1020

agcagcgtgg ccagcctgaa cgacatgacc cccgtgggca ggatggtgac cgccaacccc     1080

tacgtggcca gcagcaccgc caacgccaag gtgctggtgg agatcgagcc ccccttcggc     1140

gacagctaca tcgtggtggg caggggcgac aagcagatca accaccactg gcacaaggag     1200

ggcagcagca tcggcaaggc cttcagcacc accctgaagg gcgcccagag gctggccgcc     1260

ctgggcgaca ccgcctggga cttcggcagc gtgggcggcg tgttcaacag catcggcaag     1320

gccgtgcacc aggtgttcgg cggcgccttc aggaccctgt tcggcggcat gagctggatc     1380

agccccggcc tgctgggcgc cctgctgctg tggatgggcg tgaacgccag ggacaagagc     1440

atcgccctgg ccttcctggc caccggcggc gtgctgctgt tcctggccac caacgtgcac     1500

gcc                                                                   1503


<210>  588
<211>  501
<212>  PRT
<213>  Flavivirus Murray Valley encephalitis virus

<400>  588

Phe Asn Cys Leu Gly Met Ser Ser Arg Asp Phe Ile Glu Gly Ala Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Ile Thr 
            20                  25                  30          


Ile Met Ala Ala Asp Lys Pro Thr Leu Asp Ile Arg Met Met Asn Ile 
        35                  40                  45              


Glu Ala Thr Asn Leu Ala Leu Val Arg Asn Tyr Cys Tyr Ala Ala Thr 
    50                  55                  60                  


Val Ser Asp Val Ser Thr Val Ser Asn Cys Pro Thr Thr Gly Glu Ser 
65                  70                  75                  80  


His Asn Thr Lys Arg Ala Asp His Asn Tyr Leu Cys Lys Arg Gly Val 
                85                  90                  95      


Thr Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Asp Thr Cys Ala Lys Phe Thr Cys Ser Asn Ser Ala Ala Gly Arg 
        115                 120                 125             


Leu Ile Leu Pro Glu Asp Ile Lys Tyr Glu Val Gly Val Phe Val His 
    130                 135                 140                 


Gly Ser Thr Asp Ser Thr Ser His Gly Asn Tyr Ser Thr Gln Ile Gly 
145                 150                 155                 160 


Ala Asn Gln Ala Val Arg Phe Thr Ile Ser Pro Asn Ala Pro Ala Ile 
                165                 170                 175     


Thr Ala Lys Met Gly Asp Tyr Gly Glu Val Thr Val Glu Cys Glu Pro 
            180                 185                 190         


Arg Ser Gly Leu Asn Thr Glu Ala Tyr Tyr Val Met Thr Ile Gly Thr 
        195                 200                 205             


Lys His Phe Leu Val His Arg Glu Trp Phe Asn Asp Leu Leu Leu Pro 
    210                 215                 220                 


Trp Thr Ser Pro Ala Ser Thr Glu Trp Arg Asn Arg Glu Ile Leu Val 
225                 230                 235                 240 


Glu Phe Glu Glu Pro His Ala Thr Lys Gln Ser Val Val Ala Leu Gly 
                245                 250                 255     


Ser Gln Glu Gly Ala Leu His Gln Ala Leu Ala Gly Ala Ile Pro Val 
            260                 265                 270         


Glu Phe Ser Ser Ser Thr Leu Lys Leu Thr Ser Gly His Leu Lys Cys 
        275                 280                 285             


Arg Val Lys Met Glu Lys Leu Lys Leu Lys Gly Thr Thr Tyr Gly Met 
    290                 295                 300                 


Cys Thr Glu Lys Phe Thr Phe Ser Lys Asn Pro Ala Asp Thr Gly His 
305                 310                 315                 320 


Gly Thr Val Val Leu Glu Leu Gln Tyr Thr Gly Ser Asp Gly Pro Cys 
                325                 330                 335     


Lys Ile Pro Ile Ser Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val 
            340                 345                 350         


Gly Arg Met Val Thr Ala Asn Pro Tyr Val Ala Ser Ser Thr Ala Asn 
        355                 360                 365             


Ala Lys Val Leu Val Glu Ile Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 


Val Val Gly Arg Gly Asp Lys Gln Ile Asn His His Trp His Lys Glu 
385                 390                 395                 400 


Gly Ser Ser Ile Gly Lys Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln 
                405                 410                 415     


Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly 
            420                 425                 430         


Gly Val Phe Asn Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly 
        435                 440                 445             


Ala Phe Arg Thr Leu Phe Gly Gly Met Ser Trp Ile Ser Pro Gly Leu 
    450                 455                 460                 


Leu Gly Ala Leu Leu Leu Trp Met Gly Val Asn Ala Arg Asp Lys Ser 
465                 470                 475                 480 


Ile Ala Leu Ala Phe Leu Ala Thr Gly Gly Val Leu Leu Phe Leu Ala 
                485                 490                 495     


Thr Asn Val His Ala 
            500     


<210>  589
<211>  1491
<212>  DNA
<213>  Flavivirus Powassan virus

<400>  589
accaggtgca cccacctgga gaacagggac ttcgtgaccg gcacccaggg caccaccagg       60

gtgagcctgg tgctggagct gggcggctgc gtgaccatca ccgccgaggg caagcccagc      120

atcgacgtgt ggctggagga catcttccag gagagccccg ccgagaccag ggagtactgc      180

ctgcacgcca agctgaccaa caccaaggtg gaggccaggt gccccaccac cggccccgcc      240

accctgcccg aggagcacca ggccaacatg gtgtgcaaga gggaccagag cgacaggggc      300

tggggcaacc actgcggctt cttcggcaag ggcagcatcg tggcctgcgc caagttcgag      360

tgcgaggagg ccaagaaggc catgggccac gtgtacgaca gcaccaagat cacctacgtg      420

gtgaaggtgg agccccacac cggcgactac ctggccgcca acgagaccaa cagcaacagg      480

aagagcgccc agttcaccgt ggccagcgag aaggtgatcc tgaggctggg cgactacggc      540

gacgtgagcc tgacctgcaa ggtggccagc ggcatcgacg tggcccagac cgtggtgatg      600

agcctggaca gcagcaagga ccacctgccc agcgcctggc aggtgcacag ggactggttc      660

gaggacctgg ccctgccctg gaagcacaag gacaaccagg actggaacag cgtggagaag      720

ctggtggagt tcggcccccc ccacgccgtg aagatggacg tgttcaacct gggcgaccag      780

accgccgtgc tgctgaagag cctggccggc gtgcccctgg ccagcgtgga gggccagaag      840

taccacctga agagcggcca cgtgacctgc gacgtgggcc tggagaagct gaagctgaag      900

ggcaccacct acagcatgtg cgacaaggcc aagttcaagt ggaagagggt gcccgtggac      960

agcggccacg acaccgtggt gatggaggtg agctacaccg gcagcgacaa gccctgcagg     1020

atccccgtga gggccgtggc ccacggcgtg cccgccgtga acgtggccat gctgatcacc     1080

cccaacccca ccatcgagac caacggcggc ggcttcatcg agatgcagct gccccccggc     1140

gacaacatca tctacgtggg cgacctgagc cagcagtggt tccagaaggg cagcaccatc     1200

ggcaggatgt tcgagaagac caggaggggc ctggagaggc tgagcgtggt gggcgagcac     1260

gcctgggact tcggcagcgt gggcggcgtg ctgagcagcg tgggcaaggc catccacacc     1320

gtgctgggcg gcgccttcaa caccctgttc ggcggcgtgg gcttcatccc caagatgctg     1380

ctgggcgtgg ccctggtgtg gctgggcctg aacgccagga accccaccat gagcatgacc     1440

ttcctggccg tgggcgccct gaccctgatg atgaccatgg gcgtgggcgc c              1491


<210>  590
<211>  497
<212>  PRT
<213>  Flavivirus Powassan virus

<400>  590

Thr Arg Cys Thr His Leu Glu Asn Arg Asp Phe Val Thr Gly Thr Gln 
1               5                   10                  15      


Gly Thr Thr Arg Val Ser Leu Val Leu Glu Leu Gly Gly Cys Val Thr 
            20                  25                  30          


Ile Thr Ala Glu Gly Lys Pro Ser Ile Asp Val Trp Leu Glu Asp Ile 
        35                  40                  45              


Phe Gln Glu Ser Pro Ala Glu Thr Arg Glu Tyr Cys Leu His Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Lys Val Glu Ala Arg Cys Pro Thr Thr Gly Pro Ala 
65                  70                  75                  80  


Thr Leu Pro Glu Glu His Gln Ala Asn Met Val Cys Lys Arg Asp Gln 
                85                  90                  95      


Ser Asp Arg Gly Trp Gly Asn His Cys Gly Phe Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Val Ala Cys Ala Lys Phe Glu Cys Glu Glu Ala Lys Lys Ala Met 
        115                 120                 125             


Gly His Val Tyr Asp Ser Thr Lys Ile Thr Tyr Val Val Lys Val Glu 
    130                 135                 140                 


Pro His Thr Gly Asp Tyr Leu Ala Ala Asn Glu Thr Asn Ser Asn Arg 
145                 150                 155                 160 


Lys Ser Ala Gln Phe Thr Val Ala Ser Glu Lys Val Ile Leu Arg Leu 
                165                 170                 175     


Gly Asp Tyr Gly Asp Val Ser Leu Thr Cys Lys Val Ala Ser Gly Ile 
            180                 185                 190         


Asp Val Ala Gln Thr Val Val Met Ser Leu Asp Ser Ser Lys Asp His 
        195                 200                 205             


Leu Pro Ser Ala Trp Gln Val His Arg Asp Trp Phe Glu Asp Leu Ala 
    210                 215                 220                 


Leu Pro Trp Lys His Lys Asp Asn Gln Asp Trp Asn Ser Val Glu Lys 
225                 230                 235                 240 


Leu Val Glu Phe Gly Pro Pro His Ala Val Lys Met Asp Val Phe Asn 
                245                 250                 255     


Leu Gly Asp Gln Thr Ala Val Leu Leu Lys Ser Leu Ala Gly Val Pro 
            260                 265                 270         


Leu Ala Ser Val Glu Gly Gln Lys Tyr His Leu Lys Ser Gly His Val 
        275                 280                 285             


Thr Cys Asp Val Gly Leu Glu Lys Leu Lys Leu Lys Gly Thr Thr Tyr 
    290                 295                 300                 


Ser Met Cys Asp Lys Ala Lys Phe Lys Trp Lys Arg Val Pro Val Asp 
305                 310                 315                 320 


Ser Gly His Asp Thr Val Val Met Glu Val Ser Tyr Thr Gly Ser Asp 
                325                 330                 335     


Lys Pro Cys Arg Ile Pro Val Arg Ala Val Ala His Gly Val Pro Ala 
            340                 345                 350         


Val Asn Val Ala Met Leu Ile Thr Pro Asn Pro Thr Ile Glu Thr Asn 
        355                 360                 365             


Gly Gly Gly Phe Ile Glu Met Gln Leu Pro Pro Gly Asp Asn Ile Ile 
    370                 375                 380                 


Tyr Val Gly Asp Leu Ser Gln Gln Trp Phe Gln Lys Gly Ser Thr Ile 
385                 390                 395                 400 


Gly Arg Met Phe Glu Lys Thr Arg Arg Gly Leu Glu Arg Leu Ser Val 
                405                 410                 415     


Val Gly Glu His Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Ser 
            420                 425                 430         


Ser Val Gly Lys Ala Ile His Thr Val Leu Gly Gly Ala Phe Asn Thr 
        435                 440                 445             


Leu Phe Gly Gly Val Gly Phe Ile Pro Lys Met Leu Leu Gly Val Ala 
    450                 455                 460                 


Leu Val Trp Leu Gly Leu Asn Ala Arg Asn Pro Thr Met Ser Met Thr 
465                 470                 475                 480 


Phe Leu Ala Val Gly Ala Leu Thr Leu Met Met Thr Met Gly Val Gly 
                485                 490                 495     


Ala 
    


<210>  591
<211>  1692
<212>  DNA
<213>  Alphainfluenzavirus Influenza A virus H5N1

<400>  591
atggagagga tcgtgctgct gctggccatc gtgagcctgg tgaagagcga ccagatctgc       60

atcggctacc acgccaacaa gagcaccaag caggtggaca ccatcatgga gaagaacgtg      120

accgtgaccc acgcccagga catcctggag aggacccaca acggcaagct gtgcagcctg      180

aacggcgtga agcccctgat cctgagggac tgcagcgtgg ccggctggct gctgggcaac      240

cccatgtgcg acgagttcct gaacgtgccc gagtggagct acatcgtgga gaaggacaac      300

cccatcaaca gcctgtgcta ccccggcgac ttcaacgact acgaggagct gaagcacctg      360

ctgagcagca ccaaccactt cgagaagatc cagatcatcc ccaggagcag ctggagcaac      420

cacgacgcca gcagcggcgt gagcagcgcc tgcccctaca tcggcaggag cagcttcttc      480

aggaacgtgg tgtggctgat caagaaggac aacgcctacc ccaccatcaa gaggagctac      540

aacaacacca accaggagga cctgctgatc ctgtggggca tccaccaccc caacgacgcc      600

gccgagcaga ccaagctgta ccagaacccc accacctacg tgagcgtggg caccagcacc      660

ctgaaccaga ggagcatccc cgagatcgcc accaggccca aggtgaacgg ccagagcggc      720

aggatggagt tcttctggac catcctgaag cccaacgacg ccatcaactt cgagagcaac      780

ggcaacttca tcgcccccga gtacgcctac aagatcgtga agaagggcga cagcgccatc      840

atgaagagcg gcctggccta cggcaactgc gacaccaagt gccagacccc cgtgggcgcc      900

atcaacagca gcatgccctt ccacaacatc cacccccaca ccatcggcga gtgccccaag      960

tacgtgaaga gcgacaggct ggtgctggcc accggcctga ggaacgtgcc ccagaggaag     1020

aagaggggcc tgttcggcgc catcgccggc ttcatcgagg gcggctggca gggcatggtg     1080

gacggctggt acggctacca ccacagcaac gagcagggca gcggctacgc cgccgacaag     1140

gagagcaccc agaaggccat cgacggcatc accaacaagg tgaacagcat catcgacaag     1200

atgaacaccc agttcaaggc cgtgggcaag gagttcaaca acctggagag gagggtggag     1260

aacctgaaca agaagatgga ggacggcttc ctggacgtgt ggacctacaa cgtggagctg     1320

ctggtgctga tggagaacga gaggaccctg gacttccacg acagcaacgt gaagaacctg     1380

tacgacaagg tgaggctgca gctgaaggac aacgccaggg agctgggcaa cggctgcttc     1440

gagttctacc acaagtgcga caacgagtgc atggagagcg tgaggaacgg cacctacgac     1500

tacccccagt acagcgagga ggccaggctg aacagggagg agatcagcgg cgtgaagctg     1560

gagagcatgg gcgtgtacca gatcctgagc atctacagca ccgtggccag cagcctggcc     1620

ctggccatca tgatcgccgg cctgagcttc tggatgtgca gcaacggcag cctgcagtgc     1680

aggatctgca tc                                                         1692


<210>  592
<211>  564
<212>  PRT
<213>  Alphainfluenzavirus Influenza A virus H5N1

<400>  592

Met Glu Arg Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Lys Ser Thr Lys Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Arg Thr His Asn Gly Lys Leu Cys Ser Leu Asn Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Leu Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Asp Asn Pro Ile Asn Ser Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Ser Thr Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Arg Ser Ser Trp Ser Asn His Asp Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Ile Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asp Asn Ala Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Ile Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Val Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Ser Ile Pro Glu Ile Ala Thr Arg Pro Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Gly Leu Ala Tyr Gly 
        275                 280                 285             


Asn Cys Asp Thr Lys Cys Gln Thr Pro Val Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro His Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asp Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Gln Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Lys Ala Val Gly Lys Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Val Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Val Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Lys Asp Asn Ala Arg Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Asn Arg 
            500                 505                 510         


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
    530                 535                 540                 


Ile Ala Gly Leu Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
545                 550                 555                 560 


Arg Ile Cys Ile 
                


<210>  593
<211>  1680
<212>  DNA
<213>  Alphainfluenzavirus Influenza A virus H7N9

<400>  593
atgaacaccc agatcctggt gttcgccctg atcgccatca tccccaccaa cgccgacaag       60

atctgcctgg gccaccacgc cgtgagcaac ggcaccaagg tgaacaccct gaccgagagg      120

ggcgtggagg tggtgaacgc caccgagacc gtggagagga ccaacatccc caggatctgc      180

agcaagggca agaggaccgt ggacctgggc cagtgcggcc tgctgggcac catcaccggc      240

cccccccagt gcgaccagtt cctggagttc agcgccgacc tgatcatcga gaggagggag      300

ggcagcgacg tgtgctaccc cggcaagttc gtgaacgagg aggccctgag gcagatcctg      360

agggagagcg gcggcatcga caaggaggcc atgggcttca cctacagcgg catcaggacc      420

aacggcgcca ccagcgcctg caggaggagc ggcagcagct tctacgccga gatgaagtgg      480

ctgctgagca acaccgacaa cgccgccttc ccccagatga ccaagagcta caagaacacc      540

aggaagagcc ccgccctgat cgtgtggggc atccaccaca gcgtgagcac cgccgagcag      600

accaagctgt acggcagcgg caacaagctg gtgaccgtgg gcagcagcaa ctaccagcag      660

agcttcgtgc ccagccccgg cgccaggccc caggtgaacg gcatcagcgg caggatcgac      720

ttccactggc tgatgctgaa ccccaacgac accgtgacct tcagcttcaa cggcgccttc      780

atcgcccccg acagggccag cttcctgagg ggcaagagca tgggcatcca gagcggcgtg      840

caggtggacg ccaactgcga gggcgactgc taccacagcg gcggcaccat catcagcaac      900

ctgcccttcc agaacatcga cagcagggcc gtgggcaagt gccccaggta cgtgaagcag      960

aggagcctgc tgctggccac cggcatgaag aacgtgcccg agatccccaa gggcaggggc     1020

ctgttcggcg ccatcgccgg cttcatcgag aacggctggg agggcctgat cgacggctgg     1080

tacggcttca ggcaccagaa cgcccagggc gagggcaccg ccgccgacta caagagcacc     1140

cagagcgcca tcgaccagat caccggcaag ctgaacaggc tgatcgagaa gaccaaccag     1200

cagttcgagc tgatcgacaa cgagttcaac gaggtggaga agcagatcgg caacgtgatc     1260

aactggacca gggacagcat caccgaggtg tggagctaca acgccgagct gctggtggcc     1320

atggagaacc agcacaccat cgacctggcc gacagcgaga tggacaagct gtacgagagg     1380

gtgaagaggc agctgaggga gaacgccgag gaggacggca ccggctgctt cgagatcttc     1440

cacaagtgcg acgacgactg catggccagc atcaggaaca acacctacga ccacagcaag     1500

tacagggagg aggccatgca gaacaggatc cagatcgacc ccgtgaagct gagcagcggc     1560

tacaaggacg tgatcctgtg gttcagcttc ggcgccagct gcttcatcct gctggccatc     1620

gtgatgggcc tggtgttcat ctgcgtgaag aacggcaaca tgaggtgcac catctgcatc     1680


<210>  594
<211>  560
<212>  PRT
<213>  Alphainfluenzavirus Influenza A virus H7N9

<400>  594

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Ile Ala Ile Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Thr Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys 
    50                  55                  60                  


Arg Thr Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly 
65                  70                  75                  80  


Pro Pro Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile 
                85                  90                  95      


Glu Arg Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn 
            100                 105                 110         


Glu Glu Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys 
        115                 120                 125             


Glu Ala Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr 
    130                 135                 140                 


Ser Ala Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp 
145                 150                 155                 160 


Leu Leu Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser 
                165                 170                 175     


Tyr Lys Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His 
            180                 185                 190         


His Ser Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn 
        195                 200                 205             


Lys Leu Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro 
    210                 215                 220                 


Ser Pro Gly Ala Arg Pro Gln Val Asn Gly Ile Ser Gly Arg Ile Asp 
225                 230                 235                 240 


Phe His Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe 
                245                 250                 255     


Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys 
            260                 265                 270         


Ser Met Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly 
        275                 280                 285             


Asp Cys Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln 
    290                 295                 300                 


Asn Ile Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln 
305                 310                 315                 320 


Arg Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro 
                325                 330                 335     


Lys Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly 
            340                 345                 350         


Trp Glu Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala 
        355                 360                 365             


Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile 
    370                 375                 380                 


Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln 
385                 390                 395                 400 


Gln Phe Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile 
                405                 410                 415     


Gly Asn Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser 
            420                 425                 430         


Tyr Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp 
        435                 440                 445             


Leu Ala Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln 
    450                 455                 460                 


Leu Arg Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe 
465                 470                 475                 480 


His Lys Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr 
                485                 490                 495     


Asp His Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile 
            500                 505                 510         


Asp Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe 
        515                 520                 525             


Ser Phe Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu 
    530                 535                 540                 


Val Phe Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
545                 550                 555                 560 


<210>  595
<211>  1821
<212>  DNA
<213>  Morbillivirus Canine Distemper Virus

<400>  595
atgctgagct accaggacaa ggtgggcgcc ttctacaagg acaacgccag ggccaacagc       60

agcaagctga gcctggtgac cgaggagcag ggcggcagga ggccccccta cctgctgttc      120

gtgctgctga tcctgctggt gggcatcatg gccctgctgg ccatcaccgg cgtgaggttc      180

caccaggtga gcaccagcaa catggagttc agcaggctgc tgaaggagga catggagaag      240

agcgaggccg tgcaccacca ggtgatcgac gtgctgaccc ccctgttcaa gatcatcggc      300

gacgaggtgg gcctgaggct gccccagaag ctgaacgaga tcaagcagtt catcctgcag      360

aagaccaact tcttcaaccc caacagggag ttcgacttca gggacctgca ctggtgcatc      420

aaccccccca gcaagatcaa ggtgaacttc accaactact gcgacaccat cggcatcagg      480

aagagcatcg ccagcgccgc caaccccatc ctgctgagcg cccacaccgg cggcaggggc      540

gacatcttcc ccccctacag gtgcagcggc gccaccacca gcgtgggcag ggtgttcccc      600

ctgagcgtga gcctgagcat gagcctgatc agcaggacca gcgagatcat caacatgctg      660

accgccatca gcgacggcgt gtacggcaag acctacctgc tggtgcccga ctacatcgag      720

ggcgagttcg acacccagaa gatcagggtg ttcgagatcg gcttcatcaa gaggtggctg      780

aacgacatgc ccctgctgca gaccaccaac tacatggtgc tgcccgagaa cagcaaggcc      840

aaggtgtgca ccatcgccgt gggcgagctg accctggcca gcctgtgcgt ggacgagagc      900

accatcctgc tgtaccacga cagcaacggc agccaggacg gcatcctggt ggtgaccctg      960

ggcatcttcg gcgccacccc catggaccag gtggaggagg tgatccccgt ggcccacccc     1020

agcgtggaga agatccacat caccaaccac aggggcttca tcaaggacag catcgccacc     1080

tggatggtgc ccgccctggt gagcgagaag caggaggagc agaagagctg cctggagagc     1140

gcctgccaga ggaagagcta ccccatgtgc aaccagacca gctgggagcc cttcggcggc     1200

ggccagctgc ccagctacgg caggctgacc ctgcccctgg accccagcat cgacctgcag     1260

ctgaacatca gcttcaccta cggccccgtg atcctgaacg gcaacggcat ggactactac     1320

gagagccccc tgctgggcag cggctggctg accatccccc ccaagaacgg caccgtgctg     1380

ggcctgatca acaaggccgg caggggcgac cagttcaccg tgatccccca cgtgctgacc     1440

ttcgccccca gggagagcag cggcaactgc tacctgccca tccagaccag ccagatcatg     1500

gacaaggacg tgctgaccga gagcaacctg gtggtgctgc ccacccagaa cttcaggtac     1560

gtgatcgcca cctacgacat cagcaggggc gaccacgcca tcgtgtacta cgtgtacgac     1620

cccatcagga ccatcagcta cacccacccc ttcaggctga ccaccaaggg caggcccgac     1680

ttcctgagga tcgagtgctt cgtgtgggac gacgacctgt ggtgccacca gttctacagg     1740

ttcgagaccg acagcaccaa cagcaccacc agcgtggaga acctggtgag gatcaggttc     1800

agctgcagca ggagcaagcc c                                               1821


<210>  596
<211>  607
<212>  PRT
<213>  Morbillivirus Canine Distemper Virus

<400>  596

Met Leu Ser Tyr Gln Asp Lys Val Gly Ala Phe Tyr Lys Asp Asn Ala 
1               5                   10                  15      


Arg Ala Asn Ser Ser Lys Leu Ser Leu Val Thr Glu Glu Gln Gly Gly 
            20                  25                  30          


Arg Arg Pro Pro Tyr Leu Leu Phe Val Leu Leu Ile Leu Leu Val Gly 
        35                  40                  45              


Ile Met Ala Leu Leu Ala Ile Thr Gly Val Arg Phe His Gln Val Ser 
    50                  55                  60                  


Thr Ser Asn Met Glu Phe Ser Arg Leu Leu Lys Glu Asp Met Glu Lys 
65                  70                  75                  80  


Ser Glu Ala Val His His Gln Val Ile Asp Val Leu Thr Pro Leu Phe 
                85                  90                  95      


Lys Ile Ile Gly Asp Glu Val Gly Leu Arg Leu Pro Gln Lys Leu Asn 
            100                 105                 110         


Glu Ile Lys Gln Phe Ile Leu Gln Lys Thr Asn Phe Phe Asn Pro Asn 
        115                 120                 125             


Arg Glu Phe Asp Phe Arg Asp Leu His Trp Cys Ile Asn Pro Pro Ser 
    130                 135                 140                 


Lys Ile Lys Val Asn Phe Thr Asn Tyr Cys Asp Thr Ile Gly Ile Arg 
145                 150                 155                 160 


Lys Ser Ile Ala Ser Ala Ala Asn Pro Ile Leu Leu Ser Ala His Thr 
                165                 170                 175     


Gly Gly Arg Gly Asp Ile Phe Pro Pro Tyr Arg Cys Ser Gly Ala Thr 
            180                 185                 190         


Thr Ser Val Gly Arg Val Phe Pro Leu Ser Val Ser Leu Ser Met Ser 
        195                 200                 205             


Leu Ile Ser Arg Thr Ser Glu Ile Ile Asn Met Leu Thr Ala Ile Ser 
    210                 215                 220                 


Asp Gly Val Tyr Gly Lys Thr Tyr Leu Leu Val Pro Asp Tyr Ile Glu 
225                 230                 235                 240 


Gly Glu Phe Asp Thr Gln Lys Ile Arg Val Phe Glu Ile Gly Phe Ile 
                245                 250                 255     


Lys Arg Trp Leu Asn Asp Met Pro Leu Leu Gln Thr Thr Asn Tyr Met 
            260                 265                 270         


Val Leu Pro Glu Asn Ser Lys Ala Lys Val Cys Thr Ile Ala Val Gly 
        275                 280                 285             


Glu Leu Thr Leu Ala Ser Leu Cys Val Asp Glu Ser Thr Ile Leu Leu 
    290                 295                 300                 


Tyr His Asp Ser Asn Gly Ser Gln Asp Gly Ile Leu Val Val Thr Leu 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Thr Pro Met Asp Gln Val Glu Glu Val Ile Pro 
                325                 330                 335     


Val Ala His Pro Ser Val Glu Lys Ile His Ile Thr Asn His Arg Gly 
            340                 345                 350         


Phe Ile Lys Asp Ser Ile Ala Thr Trp Met Val Pro Ala Leu Val Ser 
        355                 360                 365             


Glu Lys Gln Glu Glu Gln Lys Ser Cys Leu Glu Ser Ala Cys Gln Arg 
    370                 375                 380                 


Lys Ser Tyr Pro Met Cys Asn Gln Thr Ser Trp Glu Pro Phe Gly Gly 
385                 390                 395                 400 


Gly Gln Leu Pro Ser Tyr Gly Arg Leu Thr Leu Pro Leu Asp Pro Ser 
                405                 410                 415     


Ile Asp Leu Gln Leu Asn Ile Ser Phe Thr Tyr Gly Pro Val Ile Leu 
            420                 425                 430         


Asn Gly Asn Gly Met Asp Tyr Tyr Glu Ser Pro Leu Leu Gly Ser Gly 
        435                 440                 445             


Trp Leu Thr Ile Pro Pro Lys Asn Gly Thr Val Leu Gly Leu Ile Asn 
    450                 455                 460                 


Lys Ala Gly Arg Gly Asp Gln Phe Thr Val Ile Pro His Val Leu Thr 
465                 470                 475                 480 


Phe Ala Pro Arg Glu Ser Ser Gly Asn Cys Tyr Leu Pro Ile Gln Thr 
                485                 490                 495     


Ser Gln Ile Met Asp Lys Asp Val Leu Thr Glu Ser Asn Leu Val Val 
            500                 505                 510         


Leu Pro Thr Gln Asn Phe Arg Tyr Val Ile Ala Thr Tyr Asp Ile Ser 
        515                 520                 525             


Arg Gly Asp His Ala Ile Val Tyr Tyr Val Tyr Asp Pro Ile Arg Thr 
    530                 535                 540                 


Ile Ser Tyr Thr His Pro Phe Arg Leu Thr Thr Lys Gly Arg Pro Asp 
545                 550                 555                 560 


Phe Leu Arg Ile Glu Cys Phe Val Trp Asp Asp Asp Leu Trp Cys His 
                565                 570                 575     


Gln Phe Tyr Arg Phe Glu Thr Asp Ser Thr Asn Ser Thr Thr Ser Val 
            580                 585                 590         


Glu Asn Leu Val Arg Ile Arg Phe Ser Cys Ser Arg Ser Lys Pro 
        595                 600                 605         


<210>  597
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  597
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  598
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  598
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgacgcgucc ucgagcagaa gcaucaaag                              99


<210>  599
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  599
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgcuccguuc gagcagaagc aucaaag                                97


<210>  600
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  600
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcccu cuucggaggg aagcaucaaa g                                      91


<210>  601
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  601
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcagga guuucuaugg aaacccugaa gcaucaaag                              99


<210>  602
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  602
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  603
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  603
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcg cuugcgcaga agcaucaaag                                        90


<210>  604
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  604
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  605
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  605
uacuggcgcu uuuaucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  606
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  606
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga cuucgguccg auaaauaaga agcaucaaag                 110


<210>  607
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  607
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcacau gaggauuacc caugugaagc aucaaag                                97


<210>  608
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  608
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucgugaga aauccgauaa auaagaagca ucaaag                     106


<210>  609
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  609
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugca ugucuaagac agcagaagca ucaaag                                 96


<210>  610
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  610
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccga agcaucaaag                                        90


<210>  611
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  611
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaauc cauugcacuc cggauugaag caucaaag                               98


<210>  612
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  612
uacuggcgcu uuucucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  613
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  613
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  614
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  614
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cguuugcggc uacgagcaga agcaucaaag                            100


<210>  615
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  615
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagag auaaauaaga agcaucaaag                            100


<210>  616
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  616
uacggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  617
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  617
uacuggcgcc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  618
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  618
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaucggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  619
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  619
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  620
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  620
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagaa auccgauaaa uaagaagcau caaag                      105


<210>  621
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  621
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggagagaaau ccgauaaaua agaagcauca aag                        103


<210>  622
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  622
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gagauaaaua agaagcauca aag                        103


<210>  623
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  623
uacuggcgcu uuuaucucau uacuuuggag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag aguauccgau aaauaagaag caucaaag                   108


<210>  624
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  624
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  625
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  625
agcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cggagagaaa ugccgauaaa uaagaagcau caaag                      105


<210>  626
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  626
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaauaagaa gcaucaaag                  109


<210>  627
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  627
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uguaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  628
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  628
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggacuucggu ccgauaaaua agcgcaucaa ag                         102


<210>  629
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  629
uacuggcgcu uuucucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  630
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  630
guggcgcuuu uaucucauua cuuugagagc caucaccagc gacuaugucg uauggguaaa       60

gcgcuuauuu aucggagaga aauccgauaa auaagaagca ucaaag                     106


<210>  631
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  631
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaccuuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag                 110


<210>  632
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  632
gauggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  633
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  633
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaagaagca ucaaag                     106


<210>  634
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  634
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaucuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  635
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  635
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aaggcuuauu uaucggagag aaauccgaua aaaagaagca ucaaag                     106


<210>  636
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  636
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaaagaagc aucaaag                    107


<210>  637
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  637
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  638
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  638
cggcgcuuuu cucgcauuac uuugagagcc aucaccagcg acuaugucgu auggguaaag       60

cgcuuauugu aucgagagau aaauaagaag caucaaag                               98


<210>  639
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  639
cacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  640
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  640
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau guaucggcuu cggccgauac auaagaagca ucaaag                     106


<210>  641
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  641
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uguaucggcu ucggccgaua cauaagaagc aucaaag                    107


<210>  642
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  642
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggug       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  643
<211>  64
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  643
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaag                                                                    64


<210>  644
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  644
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

ag                                                                      62


<210>  645
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  645
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

agcgcuuauu uaucggcuuc ggccgauaaa uaagaagcau caaag                      105


<210>  646
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  646
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuaca cugggaucgc ugaauuagag aucggcgucc uuucauucua uauacuuugg      120

aguuuuaaaa ugucucuaag uacagaagca ucaaag                                156


<210>  647
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  647
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuucggucgu auggguaaag       60

cgcuuauuua ucggcuucgg ccgauaaaua agaagcauca aag                        103


<210>  648
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  648
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau uuaucggcuu cggccgauaa auaagaagca ucaaag                     106


<210>  649
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  649
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  650
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  650
uacuggcgcu uuuaucucau uacuuugaga gccaugcucc accagcgacu augucguaug       60

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              112


<210>  651
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  651
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgggguu aggguuaggg uuagggaagc aucaaag                                97


<210>  652
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  652
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcggaggg agggagggag agggaaagca ucaaag                                 96


<210>  653
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  653
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcguuggg uuaggguuag gguuagggaa aagcaucaaa g                          101


<210>  654
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  654
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccgg aagcaucaaa g                                      91


<210>  655
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  655
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccugc ucaguacgag aggaaccgca ggaagcauca aag                        103


<210>  656
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  656
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  657
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  657
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  658
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  658
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  659
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  659
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  660
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  660
uacuggcgcc uuuaucugca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  661
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  661
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  662
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  662
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  663
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  663
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  664
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  664
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  665
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  665
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  666
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  666
uacuggcgcc uuuaucauca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  667
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  667
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg ccggcauggu      120

cccagccucc ucgcuggcgc cggcugggca acauuccgag gggaccgucc ccucgguaau      180

ggcgaauggg accc                                                        194


<210>  668
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  668
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  669
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  669
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga aauccgauaa auaagaagca ucaaag                     106


<210>  670
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  670
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  671
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  671
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccgga cuucgguccg gaagcaucaa ag                                     92


<210>  672
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  672
uacuggcgcu uuuaucggau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  673
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  673
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  674
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  674
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  675
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  675
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  676
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  676
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gucggcaugg      120

caucuccacc uccucgcggu ccgaccuggg cauccgaagg aggacgcacg uccacucgga      180

uggcuaaggg agagcca                                                     197


<210>  677
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  677
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggcg caucaaag                                          88


<210>  678
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  678
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaguu uuggccggca      120

uggucccagc cuccucgcug gcgccggcug ggcaacaugc uucggcaugg cgaaugggac      180

cccggg                                                                 186


<210>  679
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  679
gauggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  680
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  680
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  681
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  681
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucuuacg gacuucgguc cguaagagca ucaaag                                 96


<210>  682
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  682
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucggacg accucucggu cguccgagca ucaaag                                 96


<210>  683
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  683
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc ugucaccgga      120

ugugcuuucc ggucugauga guccgugagg acgaaacagg                            160


<210>  684
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  684
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  685
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  685
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  686
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  686
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucaggug ggacgaccuc ucggucgucc uaucugagca ucaaag                     106


<210>  687
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  687
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagga uggccggcau      120

ggucccagcc uccucgcugg cgccggcugg gcaacaccuu cggguggcga augggac         177


<210>  688
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  688
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  689
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  689
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguacugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  690
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  690
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgugag aaauccgaua aauaagaagc aucaaag                    107


<210>  691
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  691
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  692
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  692
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  693
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  693
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  694
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  694
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  695
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  695
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  696
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  696
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  697
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  697
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  698
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  698
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  699
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  699
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  700
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  700
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  701
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  701
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  702
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  702
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  703
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  703
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  704
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  704
gauggccggc auggucccag ccuccucgcu ggcgccggcu gggcaacacc uucggguggc       60

gaaugggacu acuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc      120

guauggguaa agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag         177


<210>  705
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  705
ggccggcaug gucccagccu ccucgcuggc gccggcuggg caacauuccg aggggaccgu       60

ccccucggua auggcgaaug ggacccuacu ggcgcuuuua ucucauuacu uugagagcca      120

ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau      180

aagaagcauc aaag                                                        194


<210>  706
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  706
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagcgca ucaaag                                 96


<210>  707
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  707
cgugguuagg gccacguuaa auaguugcuu aagcccuaag cguugaucuu cggaucaggu       60

gcaauacugg cgcuuuuauc ucauuacuuu gagagccauc accagcgacu augucguaug      120

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              172


<210>  708
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  708
gggucggcau ggcaucucca ccuccucgcg guccgaccug ggcauccgaa ggaggacgca       60

cguccacucg gauggcuaag ggagagccau acuggcgcuu uuaucucauu acuuugagag      120

ccaucaccag cgacuauguc guauggguaa agcgcuuauu uaucggagag aaauccgaua      180

aauaagaagc aucaaag                                                     197


<210>  709
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  709
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc aguacugaug      120

aguccgugag gacgaaacga guaagcucgu cuacuggcgc uuuuaucuca u               171


<210>  710
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  710
uacuggcgcc uuuaucucau uacuuuagag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  711
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  711
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgu acuggcgcuu       60

uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa agcgcuuauu      120

uaucggagag aaauccgaua aauaagaagc aucaaag                               157


<210>  712
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  712
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugcgca ucaaag                     106


<210>  713
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  713
uacuggcgcc uuuaucucau uacuuuagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  714
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  714
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagca uuccucagaa      120

aaugacaaac cuguggggcg uaaguagauc uucggaucua ugaucgugca gacguuaaaa      180

ucaggu                                                                 186


<210>  715
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  715
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucgcgu guagcgaagc a               171


<210>  716
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  716
cauuccucag aaaaugacaa accugugggg cguaaguaga ucuucggauc uaugaucgug       60

cagacguuaa aaucagguua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  717
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  717
uuuuggccgg caugguccca gccuccucgc uggcgccggc ugggcaacau gcuucggcau       60

ggcgaauggg accccgggua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  718
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  718
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgc guguagcgaa       60

gcauacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  719
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  719
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gagccccgcu      120

gaugaggucg gggagaccga aagggacuuc ggucccuacg gggcuccc                   168


<210>  720
<211>  144
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  720
ccacccccac caccaccccc acccccacca ccacccuacu ggcgcuuuua ucucauuacu       60

uugagagcca ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa      120

uccgauaaau aagaagcauc aaag                                             144


<210>  721
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  721
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucg                               157


<210>  722
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  722
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg ugguuagggc      120

cacguuaaau aguugcuuaa gcccuaagcg uugaucuucg gaucaggugc aa              172


<210>  723
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  723
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg caauaaagcg      120

guuacaagcc cgcaaaaaua gcagaguaau gucgcgauag cgcggcauua augcagcuuu      180

auug                                                                   184


<210>  724
<211>  122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  724
uacuggcgcu uuuaucucau uacuauuauc ucauuacuuu gagagccauc accagcgacu       60

augucguaug gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa      120

ag                                                                     122


<210>  725
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  725
ggcaauaaag cgguuacaag cccgcaaaaa uagcagagua augucgcgau agcgcggcau       60

uaaugcagcu uuauuguacu ggcgcuuuua ucucauuacu uugagagcca ucaccagcga      120

cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau aagaagcauc      180

aaag                                                                   184


<210>  726
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  726
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagac ccgcaaggcc      120

gacggcaucc gccgccgcug gugcaagucc agccgccccu ucgggggcgg gcgcucaugg      180

guaac                                                                  185


<210>  727
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  727
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aag                                                                     63


<210>  728
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  728
gggagccccg cugaugaggu cggggagacc gaaagggacu ucggucccua cggggcuccc       60

uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua      120

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   168


<210>  729
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  729
ccaguacuga ugaguccgug aggacgaaac gaguaagcuc gucuacuggc gcuuuuaucu       60

cauuacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  730
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  730
acccgcaagg ccgacggcau ccgccgccgc uggugcaagu ccagccgccc cuucgggggc       60

gggcgcucau ggguaacuac uggcgcuuuu aucucauuac uuugagagcc aucaccagcg      120

acuaugucgu auggguaaag cgcuuauuua ucggagagaa auccgauaaa uaagaagcau      180

caaag                                                                  185


<210>  731
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  731
ccugucaccg gaugugcuuu ccggucugau gaguccguga ggacgaaaca gguacuggcg       60

cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg uaaagcgcuu      120

auuuaucgga gagaaauccg auaaauaaga agcaucaaag                            160


<210>  732
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  732
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag                            100


<210>  733
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  733
guacuggcgc uuuuaucuga uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcuccc ucuucggagg gagcaucaaa g                                      91


<210>  734
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  734
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  735
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  735
acuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  736
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  736
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  737
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  737
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  738
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  738
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  739
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  739
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  740
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  740
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  741
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  741
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  742
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  742
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  743
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  743
acuggcgccu uuaucaucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  744
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  744
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  745
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  745
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaag                                 96


<210>  746
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  746
acuggcacuu uuaccugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  747
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  747
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  748
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  748
acuggcccuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  749
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  749
acuggcgcuu uuaccugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  750
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  750
acuggcgcuu uuaucugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  751
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  751
acuggcaccu uuaccugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  752
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  752
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  753
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  753
acuggccccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  754
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  754
acuggcgccu uuaucugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  755
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  755
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  756
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  756
gacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  757
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  757
acuggcgccu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  758
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  758
acuggcgcau uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  759
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  759
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  760
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  760
acuggcgcuu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  761
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  761
acuggcgcau uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  762
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  762
acuggcgcuu uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  763
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  763
acuggcgcuu uuauucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  764
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  764
acggcgcuuu uaucugauua cuuugagagc caucaccagc gacuaugucg uaguggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  765
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  765
acuggcgcuu uuauaugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  766
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  766
acuggcgcuu uuaucuugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  767
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  767
acuggcgcuu uuaucugauu acuuugagag ccagcaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  768
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  768
acuggcgcug uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  769
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  769
acuggcgcuc uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  770
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  770
acuggcgcuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  771
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  771
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  772
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  772
acuggcgcuu ugaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  773
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  773
acuggcgcuu ucaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  774
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  774
acuggcgcug uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  775
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  775
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  776
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  776
acuggcgcuu uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  777
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  777
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  778
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  778
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  779
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  779
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucaaag                               98


<210>  780
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  780
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  781
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold Sequence

<400>  781
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  782
<211>  747
<212>  DNA
<213>  Alpharetrovirus Rous sarcoma virus

<400>  782
cctgtggtta tcaagacaga gggccctgct tggacccctc tggaaccaaa gctgattaca       60

agactcgccg acaccgtgcg gaccaagggc ctgcggagcc ctatcaccat ggccgagatg      120

gaagctctga tgagcagccc actgctgccc cacgacgtga ccaacctgat gagagtgatc      180

ctgggccccg ccccttacgc cctgtggatg gacgcctggg gggtgcagct gcagaccgtg      240

attgccgccg ccaccagaga tcctagacac cctgctaacg gccaaggcag aggcgaaaga      300

accaaccttg acagactgaa aggcctggcc gatggaatgg tcggcaacag cgaaggccag      360

gccgccctgc tgagacctgg cgagctggtg gctatcacag ccagcgccct gcaggccttc      420

agagaagtgg cccgactggc tgagcccacg gacccttggg ccgacatcat gcagggccct      480

tctgagagct tcgtggactt cgccaataga ctgatcaagg ccgtcgaggg cagcgatctt      540

cctcctagcg cgagagcccc tgttatcatc gactgcttcc ggcagaaaag ccagcccgac      600

atccaacagc tgatcagagc cgccccttcc accctgacca caccaggcga gatcatcaag      660

tacgtgctgg atagacagaa gaccgcccct ctgaccgatc agggcatcgc cgctgccatg      720

tcctctgcca tccagcctct ggtgatg                                          747


<210>  783
<211>  4787
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-(-1)-X-PR plasmid sequence

<400>  783
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc caaagaagaa gcggaaggtc tctagacaag     1800

agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac acaaagaagg     1860

ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct gacctgagag     1920

agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc agcaacacca     1980

gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa gccatcctgc     2040

acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga gttgctcagc     2100

ccgctcctaa gaacatcgac cagagaaagc tgatccccgt gaaggacggc aacgagagac     2160

tgacctctag cggctttgcc tgcagccagt gttgccagcc tctgtacgtg tacaagctgg     2220

aacaagtgaa cgacaagggc aagccccaca ccaactactt cggcagatgc aacgtgtccg     2280

agcacgagag gctgatcctg ctgtctcctc acaagcccga ggccaacgat gagctggtca     2340

catacagcct gggcaagttc ggacagagag ccctggactt ctacagcatc cacgtgacca     2400

gggagagcaa tcaccctgtg aagcccctgg aacagatcgg cggcaatagc tgtgcctctg     2460

gacctgtggg aaaagccctg agcgacgcct gtatgggagc cgtggcatcc ttcctgacca     2520

agtaccagga catcatcctg gaacaccaga aagtgatcaa gaagaacgag aaaagactgg     2580

ccaacctcaa ggatatcgcc agcgctaacg gcctggcctt tcctaagatc accctgcctc     2640

cacagcctca caccaaagag ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga     2700

tttgggtcaa cctgaatctg tggcagaagc tgaagatcgg cagggacgaa gccaagccac     2760

tgcagagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg     2820

attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca     2880

aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga     2940

gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagttc ggcgacctgc     3000

tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg     3060

agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa     3120

ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct     3180

ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc     3240

tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca     3300

tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg     3360

gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt     3420

tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa     3480

agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta     3540

tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga     3600

gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca     3660

acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag     3720

aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcatcgac cggggcgaga     3780

atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg     3840

actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga     3900

ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac tctaggaagt     3960

acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc     4020

tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg     4080

gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc     4140

tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc     4200

agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca     4260

gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag     4320

agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga     4380

aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca     4440

gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca     4500

gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac     4560

aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt     4620

accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga     4680

gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga     4740

agagaaaggt agccctcgag tacccatatg atgtccctga ctacgct                   4787


<210>  784
<211>  4787
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-(-1)-X-PR plasmid sequence

<400>  784
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc caaagaagaa gcggaaggtc tctagacaag     1800

agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac acaaagaagg     1860

ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct gacctgagag     1920

agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc agcaacacca     1980

gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa gccatcctgc     2040

acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga gttgctcagc     2100

ccgctcctaa gaacatcgac cagagaaagc tgatccccgt gaaggacggc aacgagagac     2160

tgacctctag cggctttgcc tgcagccagt gttgccagcc tctgtacgtg tacaagctgg     2220

aacaagtgaa cgacaagggc aagccccaca ccaactactt cggcagatgc aacgtgtccg     2280

agcacgagag gctgatcctg ctgtctcctc acaagcccga ggccaacgat gagctggtca     2340

catacagcct gggcaagttc ggacagagag ccctggactt ctacagcatc cacgtgacca     2400

gggagagcaa tcaccctgtg aagcccctgg aacagatcgg cggcaatagc tgtgcctctg     2460

gacctgtggg aaaagccctg agcgacgcct gtatgggagc cgtggcatcc ttcctgacca     2520

agtaccagga catcatcctg gaacaccaga aagtgatcaa gaagaacgag aaaagactgg     2580

ccaacctcaa ggatatcgcc agcgctaacg gcctggcctt tcctaagatc accctgcctc     2640

cacagcctca caccaaagag ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga     2700

tttgggtcaa cctgaatctg tggcagaagc tgaagatcgg cagggacgaa gccaagccac     2760

tgcagagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg     2820

attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca     2880

aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga     2940

gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagttc ggcgacctgc     3000

tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg     3060

agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa     3120

ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct     3180

ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc     3240

tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca     3300

tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg     3360

gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt     3420

tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa     3480

agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta     3540

tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga     3600

gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca     3660

acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag     3720

aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcatcgac cggggcgaga     3780

atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg     3840

actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga     3900

ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac tctaggaagt     3960

acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc     4020

tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg     4080

gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc     4140

tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc     4200

agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca     4260

gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag     4320

agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga     4380

aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca     4440

gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca     4500

gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac     4560

aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt     4620

accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga     4680

gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga     4740

agagaaaggt agccctcgag tacccatatg atgtccctga ctacgct                   4787


<210>  785
<211>  4869
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X-PR plasmid sequence

<400>  785
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tcctttagct tccctcagat cactctttgg cagcgacccc tcgtcacaat aaagataggg     4620

gggcaattaa aggaagctct attagataca ggagcagatg atacagtatt agaagaaatg     4680

aatttgccag gaagatggaa accaaaaatg atagggggaa ttggaggttt tatcaaagta     4740

agacagtatg atcagatact catagaaatc tgcggacata aagctatagg tacagtatta     4800

gtaggaccta cacctgtcaa cataattgga agaaatctgt tgactcagat tggctgcact     4860

ttaaatttt                                                             4869


<210>  786
<211>  4869
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X-PR plasmid sequence

<400>  786
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tcctttagct tccctcagat cactctttgg cagcgacccc tcgtcacaat aaagataggg     4620

gggcaattaa aggaagctct attagataca ggagcagatg atacagtatt agaagaaatg     4680

aatttgccag gaagatggaa accaaaaatg atagggggaa ttggaggttt tatcaaagta     4740

agacagtatg atcagatact catagaaatc tgcggacata aagctatagg tacagtatta     4800

gtaggaccta cacctgtcaa cataattgga agaaatctgt tgactcagat tggctgcact     4860

ttaaatttt                                                             4869


<210>  787
<211>  4563
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid sequence

<400>  787
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tga                                                                   4563


<210>  788
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  788
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  789
<211>  4563
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid sequence

<400>  789
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tga                                                                   4563


<210>  790
<211>  4563
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid sequence

<400>  790
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tga                                                                   4563


<210>  791
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  791
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  792
<211>  4869
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-X (no p1/p6)plasmid sequence

<400>  792
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tcctttagct tccctcagat cactctttgg cagcgacccc tcgtcacaat aaagataggg     4620

gggcaattaa aggaagctct attagataca ggagcagatg atacagtatt agaagaaatg     4680

aatttgccag gaagatggaa accaaaaatg atagggggaa ttggaggttt tatcaaagta     4740

agacagtatg atcagatact catagaaatc tgcggacata aagctatagg tacagtatta     4800

gtaggaccta cacctgtcaa cataattgga agaaatctgt tgactcagat tggctgcact     4860

ttaaatttt                                                             4869


<210>  793
<211>  4338
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1-X plasmid sequence

<400>  793
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagac cggtgcccca     1320

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1380

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1440

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1500

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1560

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1620

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1680

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1740

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1800

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     1860

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     1920

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     1980

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2040

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2100

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2160

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2220

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2280

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2340

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2400

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2460

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2520

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2580

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2640

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2700

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2760

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     2820

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     2880

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     2940

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3000

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3060

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3120

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3180

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3240

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3300

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3360

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3420

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3480

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3540

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3600

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3660

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3720

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3780

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     3840

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     3900

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     3960

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4020

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4080

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4140

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4200

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4260

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4320

gatgtccctg actacgct                                                   4338


<210>  794
<211>  4395
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-X-(-1)-PR plasmid sequence

<400>  794
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaaccgg tgccccaaag     1380

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1440

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1500

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1560

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1620

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1680

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1740

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     1800

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     1860

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     1920

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     1980

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2040

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2100

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2160

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     2220

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2280

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2340

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2400

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2460

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2520

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2580

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2640

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2700

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     2760

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     2820

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     2880

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     2940

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3000

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3060

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3120

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3180

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3240

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3300

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3360

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3420

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3480

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3540

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3600

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3660

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3720

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     3780

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     3840

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     3900

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     3960

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4020

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4080

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4140

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4200

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4260

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4320

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4380

gtccctgact acgct                                                      4395


<210>  795
<211>  4814
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X-(-1)-PR plasmid sequence

<400>  795
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaatttct tagggaagac cggtgcccca     1320

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1380

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1440

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1500

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1560

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1620

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1680

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1740

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1800

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     1860

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     1920

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     1980

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2040

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2100

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2160

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2220

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2280

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2340

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2400

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2460

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2520

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2580

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2640

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2700

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2760

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     2820

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     2880

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     2940

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3000

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3060

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3120

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3180

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3240

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3300

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3360

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3420

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3480

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3540

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3600

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3660

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3720

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3780

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     3840

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     3900

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     3960

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4020

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4080

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4140

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4200

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4260

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4320

gatgtccctg actacgctag acaggctaat tttttaggga agatctggcc ttcccacaag     4380

ggaaggccag ggaattttct tcagagcaga ccagagccaa cagccccacc agaagagagc     4440

ttcaggtttg gggaagagac aacaactccc tctcagaagc aggagccgat agacaaggaa     4500

ctgtatcctt tagcttccct cagatcactc tttggcagcg acccctcgtc acaataaaga     4560

taggggggca attaaaggaa gctctattag atacaggagc agatgataca gtattagaag     4620

aaatgaattt gccaggaaga tggaaaccaa aaatgatagg gggaattgga ggttttatca     4680

aagtaagaca gtatgatcag atactcatag aaatctgcgg acataaagct ataggtacag     4740

tattagtagg acctacacct gtcaacataa ttggaagaaa tctgttgact cagattggct     4800

gcactttaaa tttt                                                       4814


<210>  796
<211>  4649
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-NC-(-1)-PR plasmid sequence

<400>  796
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gctagacagg ctaatttttt agggaagatc     4200

tggccttccc acaagggaag gccagggaat tttcttcaga gcagaccaga gccaacagcc     4260

ccaccagaag agagcttcag gtttggggaa gagacaacaa ctccctctca gaagcaggag     4320

ccgatagaca aggaactgta tcctttagct tccctcagat cactctttgg cagcgacccc     4380

tcgtcacaat aaagataggg gggcaattaa aggaagctct attagataca ggagcagatg     4440

atacagtatt agaagaaatg aatttgccag gaagatggaa accaaaaatg atagggggaa     4500

ttggaggttt tatcaaagta agacagtatg atcagatact catagaaatc tgcggacata     4560

aagctatagg tacagtatta gtaggaccta cacctgtcaa cataattgga agaaatctgt     4620

tgactcagat tggctgcact ttaaatttt                                       4649


<210>  797
<211>  4151
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-(-1)-PR plasmid sequence

<400>  797
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct gggggacccg gccataaagc aagagttttg     3480

gctgaagcaa tgagccaagt aacaaatcca gctaccataa tgatacagaa aggcaatttt     3540

aggaaccaaa gaaagactgt taagtgtttc aattgtggca aagaagggca catagccaaa     3600

aattgcaggg cccctaggaa aaagggctgt tggaaatgtg gaaaggaagg acaccaaatg     3660

aaagattgta ctgagagaca ggctaatttt ttagggaaga tctggccttc ccacaaggga     3720

aggccaggga attttcttca gagcagacca gagccaacag ccccaccaga agagagcttc     3780

aggtttgggg aagagacaac aactccctct cagaagcagg agccgataga caaggaactg     3840

tatcctttag cttccctcag atcactcttt ggcagcgacc cctcgtcaca ataaagatag     3900

gggggcaatt aaaggaagct ctattagata caggagcaga tgatacagta ttagaagaaa     3960

tgaatttgcc aggaagatgg aaaccaaaaa tgataggggg aattggaggt tttatcaaag     4020

taagacagta tgatcagata ctcatagaaa tctgcggaca taaagctata ggtacagtat     4080

tagtaggacc tacacctgtc aacataattg gaagaaatct gttgactcag attggctgca     4140

ctttaaattt t                                                          4151


<210>  798
<211>  3926
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-PR plasmid sequence

<400>  798
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct agacaggcta attttttagg gaagatctgg     3480

ccttcccaca agggaaggcc agggaatttt cttcagagca gaccagagcc aacagcccca     3540

ccagaagaga gcttcaggtt tggggaagag acaacaactc cctctcagaa gcaggagccg     3600

atagacaagg aactgtatcc tttagcttcc ctcagatcac tctttggcag cgacccctcg     3660

tcacaataaa gatagggggg caattaaagg aagctctatt agatacagga gcagatgata     3720

cagtattaga agaaatgaat ttgccaggaa gatggaaacc aaaaatgata gggggaattg     3780

gaggttttat caaagtaaga cagtatgatc agatactcat agaaatctgc ggacataaag     3840

ctataggtac agtattagta ggacctacac ctgtcaacat aattggaaga aatctgttga     3900

ctcagattgg ctgcacttta aatttt                                          3926


<210>  799
<211>  3759
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X-PR plasmid sequence

<400>  799
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct tcctttagct tccctcagat cactctttgg     3480

cagcgacccc tcgtcacaat aaagataggg gggcaattaa aggaagctct attagataca     3540

ggagcagatg atacagtatt agaagaaatg aatttgccag gaagatggaa accaaaaatg     3600

atagggggaa ttggaggttt tatcaaagta agacagtatg atcagatact catagaaatc     3660

tgcggacata aagctatagg tacagtatta gtaggaccta cacctgtcaa cataattgga     3720

agaaatctgt tgactcagat tggctgcact ttaaatttt                            3759


<210>  800
<211>  4482
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X plasmid sequence

<400>  800
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gcttccttta gcttccctca gatcactctt     4200

tggcagcgac ccctcgtcac aataaagata ggggggcaat taaaggaagc tctattagat     4260

acaggagcag atgatacagt attagaagaa atgaatttgc caggaagatg gaaaccaaaa     4320

atgatagggg gaattggagg ttttatcaaa gtaagacagt atgatcagat actcatagaa     4380

atctgcggac ataaagctat aggtacagta ttagtaggac ctacacctgt caacataatt     4440

ggaagaaatc tgttgactca gattggctgc actttaaatt tt                        4482


<210>  801
<211>  3450
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X plasmid sequence

<400>  801
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct                                      3450


<210>  802
<211>  4173
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-X-(-1)-PR plasmid sequence

<400>  802
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gct                                  4173


<210>  803
<211>  7709
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X-X-(-1)-PR plasmid sequence

<400>  803
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gctaacttta gccagaacta tccgattgtg     4200

cagaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     4260

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     4320

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     4380

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     4440

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     4500

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     4560

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     4620

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     4680

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     4740

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     4800

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     4860

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     4920

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     4980

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     5040

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     5100

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     5160

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     5220

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     5280

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     5340

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     5400

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     5460

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     5520

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     5580

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     5640

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     5700

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     5760

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     5820

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     5880

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     5940

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     6000

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     6060

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     6120

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     6180

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     6240

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     6300

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     6360

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     6420

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     6480

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     6540

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     6600

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     6660

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     6720

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     6780

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     6840

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     6900

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     6960

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     7020

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     7080

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     7140

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     7200

ctcgagtacc catatgatgt ccctgactac gctagacagg ctaatttttt agggaagatc     7260

tggccttccc acaagggaag gccagggaat tttcttcaga gcagaccaga gccaacagcc     7320

ccaccagaag agagcttcag gtttggggaa gagacaacaa ctccctctca gaagcaggag     7380

ccgatagaca aggaactgta tcctttagct tccctcagat cactctttgg cagcgacccc     7440

tcgtcacaat aaagataggg gggcaattaa aggaagctct attagataca ggagcagatg     7500

atacagtatt agaagaaatg aatttgccag gaagatggaa accaaaaatg atagggggaa     7560

ttggaggttt tatcaaagta agacagtatg atcagatact catagaaatc tgcggacata     7620

aagctatagg tacagtatta gtaggaccta cacctgtcaa cataattgga agaaatctgt     7680

tgactcagat tggctgcact ttaaatttt                                       7709


<210>  804
<211>  7874
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-X-X-(-1)-PR plasmid sequence

<400>  804
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaatttct tagggaagac cggtgcccca     1320

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1380

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1440

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1500

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1560

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1620

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1680

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1740

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1800

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     1860

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     1920

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     1980

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2040

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2100

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2160

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2220

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2280

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2340

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2400

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2460

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2520

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2580

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2640

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2700

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2760

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     2820

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     2880

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     2940

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3000

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3060

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3120

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3180

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3240

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3300

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3360

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3420

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3480

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3540

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3600

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3660

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3720

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3780

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     3840

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     3900

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     3960

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4020

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4080

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4140

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4200

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4260

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4320

gatgtccctg actacgctaa ctttagccag aactatccga ttgtgcagac cggtgcccca     4380

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     4440

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     4500

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     4560

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     4620

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     4680

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     4740

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     4800

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     4860

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     4920

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     4980

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     5040

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     5100

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     5160

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     5220

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     5280

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     5340

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     5400

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     5460

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     5520

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     5580

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     5640

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     5700

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     5760

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     5820

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     5880

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     5940

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     6000

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     6060

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     6120

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     6180

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     6240

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     6300

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     6360

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     6420

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     6480

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     6540

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     6600

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     6660

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     6720

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     6780

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     6840

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     6900

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     6960

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     7020

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     7080

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     7140

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     7200

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     7260

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     7320

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     7380

gatgtccctg actacgctag acaggctaat tttttaggga agatctggcc ttcccacaag     7440

ggaaggccag ggaattttct tcagagcaga ccagagccaa cagccccacc agaagagagc     7500

ttcaggtttg gggaagagac aacaactccc tctcagaagc aggagccgat agacaaggaa     7560

ctgtatcctt tagcttccct cagatcactc tttggcagcg acccctcgtc acaataaaga     7620

taggggggca attaaaggaa gctctattag atacaggagc agatgataca gtattagaag     7680

aaatgaattt gccaggaaga tggaaaccaa aaatgatagg gggaattgga ggttttatca     7740

aagtaagaca gtatgatcag atactcatag aaatctgcgg acataaagct ataggtacag     7800

tattagtagg acctacacct gtcaacataa ttggaagaaa tctgttgact cagattggct     7860

gcactttaaa tttt                                                       7874


<210>  805
<211>  4566
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Gag-1%TCS-STx-HA plasmid sequence

<400>  805
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttgaga atgtttactt ccagagcggc accggtaccg gtgccccaaa gaagaagcgg     1560

aaggtctcta gacaagagat caagagaatc aacaagatca gaaggagact ggtcaaggac     1620

agcaacacaa agaaggccgg caagacaggc cccatgaaaa ccctgctcgt cagagtgatg     1680

acccctgacc tgagagagcg gctggaaaac ctgagaaaga agcccgagaa catccctcag     1740

cctatcagca acaccagcag ggccaacctg aacaagctgc tgaccgacta caccgagatg     1800

aagaaagcca tcctgcacgt gtactgggaa gagttccaga aagaccccgt gggcctgatg     1860

agcagagttg ctcagcctgc cagcaagaag atcgaccaga acaagctgaa gcccgagatg     1920

gacgagaagg gcaatctgac cacagccggc tttgcctgct ctcagtgtgg ccagcctctg     1980

ttcgtgtaca agctggaaca ggtgtccgag aaaggcaagg cctacaccaa ctacttcggc     2040

agatgtaacg tggccgagca cgagaagctg attctgctgg cccagctgaa acctgagaag     2100

gactctgatg aggccgtgac ctacagcctg ggcaagtttg gacagagagc cctggacttc     2160

tacagcatcc acgtgaccaa agaaagcaca caccccgtga agcccctggc tcagatcgcc     2220

ggcaatagat acgcctctgg acctgtgggc aaagccctgt ccgatgcctg catgggaaca     2280

atcgccagct tcctgagcaa gtaccaggac atcatcatcg agcaccagaa ggtggtcaag     2340

ggcaaccaga agagactgga aagcctgagg gagctggccg gcaaagagaa cctggaatac     2400

cccagcgtga ccctgcctcc tcagcctcac acaaaagaag gcgtggacgc ctacaacgaa     2460

gtgatcgcca gagtgagaat gtgggtcaac ctgaacctgt ggcagaagct gaaactgtcc     2520

agggacgacg ccaagcctct gctgagactg aagggcttcc ctagcttccc tctggtggaa     2580

agacaggcca atgaagtgga ttggtgggac atggtctgca acgtgaagaa gctgatcaac     2640

gagaagaaag aggatggcaa ggttttctgg cagaacctgg ccggctacaa gagacaagaa     2700

gccctgaggc cttacctgag cagcgaagag gaccggaaga agggcaagaa gttcgccaga     2760

taccagctgg gcgacctgct gctgcacctg gaaaagaagc acggcgagga ctggggcaaa     2820

gtgtacgatg aggcctggga gagaatcgac aagaaggtgg aaggcctgag caagcacatt     2880

aagctggaag aggaaagaag gagcgaggac gcccaatcta aagccgctct gaccgattgg     2940

ctgagagcca aggccagctt tgtgatcgag ggcctgaaag aggccgacaa ggacgagttc     3000

tgcagatgcg agctgaagct gcagaagtgg tacggcgatc tgagaggcaa gcccttcgcc     3060

attgaggccg agaacagcat cctggacatc agcggcttca gcaagcagta caactgcgcc     3120

ttcatttggc agaaagacgg cgtcaagaaa ctgaacctgt acctgatcat caattacttc     3180

aaaggcggca agctgcggtt caagaagatc aaacccgagg ccttcgaggc taacagattc     3240

tacaccgtga tcaacaaaaa gtccggcgag atcgtgccca tggaagtgaa cttcaacttc     3300

gacgacccca acctgattat cctgcctctg gccttcggca agagacaggg cagagagttc     3360

atctggaacg atctgctgag cctggaaacc ggctctctga agctggccaa tggcagagtg     3420

atcgagaaaa ccctgtacaa caggagaacc agacaggacg agcctgctct gtttgtggcc     3480

ctgaccttcg agagaagaga ggtgctggac agcagcaaca tcaagcccat gaacctgatc     3540

ggcgtggacc ggggcgagaa tatccctgct gtgatcgccc tgacagaccc tgaaggatgc     3600

ccactgagca gattcaagga ctccctgggc aaccctacac acatcctgag aatcggcgag     3660

agctacaaag agaagcagag gacaatccag gccaagaaag aggtggaaca gagaagagcc     3720

ggcggatact ctaggaagta cgccagcaag gccaagaatc tggccgacga catggtccga     3780

aacaccgcca gagatctgct gtactacgcc gtgacacagg acgccatgct gatcttcgag     3840

aatctgagca gaggcttcgg ccggcagggc aagagaacct ttatggccga gaggcagtac     3900

accagaatgg aagattggct cacagctaaa ctggcctacg agggactgag caagacctac     3960

ctgtccaaaa cactggccca gtatacctcc aagacctgca gcaattgcgg cttcaccatc     4020

accagcgccg actacgacag agtgctggaa aagctcaaga aaaccgccac cggctggatg     4080

accaccatca acggcaaaga gctgaaggtt gagggccaga tcacctacta caacaggtac     4140

aagaggcaga acgtcgtgaa ggatctgagc gtggaactgg acagactgag cgaagagagc     4200

gtgaacaacg acatcagcag ctggacaaag ggcagatcag gcgaggctct gagcctgctg     4260

aagaagaggt ttagccacag acctgtgcaa gagaagttcg tgtgcctgaa ctgcggcttc     4320

gagacacacg ccgatgaaca ggctgccctg aacattgcca gaagctggct gttcctgaga     4380

agccaagagt acaagaagta ccagaccaac aagaccaccg gcaacaccga caagagggcc     4440

tttgtggaaa cctggcagag cttctacaga aaaaagctga aagaagtctg gaagcccgcc     4500

gtgactagtc caaaaaagaa gagaaaggta gccctcgagt acccatatga tgtccctgac     4560

tacgct                                                                4566


<210>  806
<211>  2064
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Gag-PCS-HRV3c plasmid sequence

<400>  806
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aacctggaag ttctgttcca gggcccgaat acagagtttg ccttatcctt gctgcgtaaa     1560

aatattatga ccatcaccac cagcaaaggc gaatttaccg ggcttggcat tcacgatcgc     1620

gtctgtgtaa tacccacgca tgctcagcca ggcgatgacg ttctcgtcaa tgggcaaaaa     1680

atccgggtga aagataaata taaactggtt gatccggaaa acatcaacct ggagctgacg     1740

gtgctgactc ttgaccgtaa tgaaaaattc cgcgatattc gcggttttat cagcgaagat     1800

ctcgaaggcg tggacgcaac gctggtggtg cacagcaaca acttcactaa cactattctg     1860

gaagtggggc ctgttaccat ggcgggactg atcaatttat caagtacgcc aaccaaccgc     1920

atgattcgtt atgactacgc caccaaaacc ggtcagtgcg gcggcgtatt gtgcgcaaca     1980

ggtaaaattt ttggtattca tgtcggcggc aacggtcgtc agggcttctc ggcgcaactg     2040

aaaaaacagt acttcgttga aaag                                            2064


<210>  807
<211>  4557
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Gag-TCS-STx-HA plasmid sequence

<400>  807
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttgaga atctttattt tcagggcacc ggtgccccaa agaagaagcg gaaggtctct     1560

agacaagaga tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca     1620

aagaaggccg gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac     1680

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc     1740

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc     1800

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt     1860

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag     1920

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac     1980

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac     2040

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat     2100

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc     2160

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga     2220

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc     2280

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag     2340

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg     2400

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc     2460

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac     2520

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     2580

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     2640

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     2700

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     2760

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     2820

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     2880

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     2940

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     3000

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     3060

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     3120

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     3180

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     3240

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     3300

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     3360

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     3420

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     3480

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     3540

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     3600

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     3660

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     3720

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     3780

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     3840

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     3900

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     3960

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     4020

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     4080

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     4140

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     4200

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     4260

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     4320

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     4380

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     4440

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt     4500

ccaaaaaaga agagaaaggt agccctcgag tacccatatg atgtccctga ctacgct        4557


<210>  808
<211>  2064
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Gag-PCS-HRV3c plasmid sequence

<400>  808
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aacctggaag ttctgttcca gggcccgaat acagagtttg ccttatcctt gctgcgtaaa     1560

aatattatga ccatcaccac cagcaaaggc gaatttaccg ggcttggcat tcacgatcgc     1620

gtctgtgtaa tacccacgca tgctcagcca ggcgatgacg ttctcgtcaa tgggcaaaaa     1680

atccgggtga aagataaata taaactggtt gatccggaaa acatcaacct ggagctgacg     1740

gtgctgactc ttgaccgtaa tgaaaaattc cgcgatattc gcggttttat cagcgaagat     1800

ctcgaaggcg tggacgcaac gctggtggtg cacagcaaca acttcactaa cactattctg     1860

gaagtggggc ctgttaccat ggcgggactg atcaatttat caagtacgcc aaccaaccgc     1920

atgattcgtt atgactacgc caccaaaacc ggtcagtgcg gcggcgtatt gtgcgcaaca     1980

ggtaaaattt ttggtattca tgtcggcggc aacggtcgtc agggcttctc ggcgcaactg     2040

aaaaaacagt acttcgttga aaag                                            2064


<210>  809
<211>  4557
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Gag-PCS-STx-HA plasmid sequence

<400>  809
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aacctggaag ttctgttcca ggggcccacc ggtgccccaa agaagaagcg gaaggtctct     1560

agacaagaga tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca     1620

aagaaggccg gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac     1680

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc     1740

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc     1800

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt     1860

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag     1920

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac     1980

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac     2040

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat     2100

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc     2160

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga     2220

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc     2280

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag     2340

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata tcccagcgtg     2400

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc     2460

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac     2520

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     2580

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     2640

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     2700

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     2760

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     2820

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     2880

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     2940

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     3000

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     3060

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     3120

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     3180

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     3240

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     3300

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     3360

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     3420

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     3480

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     3540

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     3600

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     3660

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     3720

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     3780

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     3840

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     3900

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     3960

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     4020

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     4080

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     4140

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     4200

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     4260

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     4320

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     4380

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     4440

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt     4500

ccaaaaaaga agagaaaggt agccctcgag tacccatatg atgtccctga ctacgct        4557


<210>  810
<211>  2064
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Gag-PCS-HRV3c plasmid sequence

<400>  810
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aacctggaag ttctgttcca gggcccgaat acagagtttg ccttatcctt gctgcgtaaa     1560

aatattatga ccatcaccac cagcaaaggc gaatttaccg ggcttggcat tcacgatcgc     1620

gtctgtgtaa tacccacgca tgctcagcca ggcgatgacg ttctcgtcaa tgggcaaaaa     1680

atccgggtga aagataaata taaactggtt gatccggaaa acatcaacct ggagctgacg     1740

gtgctgactc ttgaccgtaa tgaaaaattc cgcgatattc gcggttttat cagcgaagat     1800

ctcgaaggcg tggacgcaac gctggtggtg cacagcaaca acttcactaa cactattctg     1860

gaagtggggc ctgttaccat ggcgggactg atcaatttat caagtacgcc aaccaaccgc     1920

atgattcgtt atgactacgc caccaaaacc ggtcagtgcg gcggcgtatt gtgcgcaaca     1980

ggtaaaattt ttggtattca tgtcggcggc aacggtcgtc agggcttctc ggcgcaactg     2040

aaaaaacagt acttcgttga aaag                                            2064


<210>  811
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 (VSV-G)plasmid sequence

<400>  811
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  812
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP29 (Rabies) plasmid sequence

<400>  812
atggttcctc aggctctcct gtttgtaccc cttctggttt ttccattgtg ttttgggaaa       60

ttccctattt acacgatacc agacaagctt ggtccctgga gtccgattga catacatcac      120

ctcagctgcc caaacaattt ggtagtggag gacgaaggat gcaccaacct gtcagggttc      180

tcctacatgg aacttaaagt tggatacatc ttagccataa aagtgaacgg gttcacttgc      240

acaggcgttg tgacggaggc tgaaacctac actaacttcg ttggttatgt cacaaccacg      300

ttcaaaagaa agcatttccg cccaacacca gatgcatgta gagccgcgta caactggaag      360

atggccggtg accccagata tgaagagtct ctacacaatc cgtaccctga ctaccgctgg      420

cttcgaactg taaaaaccac caaggagtct ctcgttatca tatctccaag tgtggcagat      480

ttggacccat atgacagatc ccttcactcg agggtcttcc ctagcgggaa gtgctcagga      540

gtagcggtgt cttctaccta ctgctccact aaccacgatt acaccatttg gatgcccgag      600

aatccgagac tagggatgtc ttgtgacatt tttaccaata gtagagggaa gagagcatcc      660

aaagggagtg agacttgcgg ctttgtagat gaaagaggcc tatataagtc tttaaaagga      720

gcatgcaaac tcaagttatg tggagttcta ggacttagac ttatggatgg aacatgggtc      780

tcgatgcaaa catcaaatga aaccaaatgg tgccctcccg ataagttggt gaacctgcac      840

gactttcgct cagacgaaat tgagcacctt gttgtagagg agttggtcag gaagagagag      900

gagtgtctgg atgcactaga gtccatcatg acaaccaagt cagtgagttt cagacgtctc      960

agtcatttaa gaaaacttgt ccctgggttt ggaaaagcat ataccatatt caacaagacc     1020

ttgatggaag ccgatgctca ctacaagtca gtcagaactt ggaatgagat cctcccttca     1080

aaagggtgtt taagagttgg ggggaggtgt catcctcatg tgaacggggt gtttttcaat     1140

ggtataatat taggacctga cggcaatgtc ttaatcccag agatgcaatc atccctcctc     1200

cagcaacata tggagttgtt ggaatcctcg gttatccccc ttgtgcaccc cctggcagac     1260

ccgtctaccg ttttcaagga cggtgacgag gctgaggatt ttgttgaagt tcaccttccc     1320

gatgtgcaca atcaggtctc aggagttgac ttgggtctcc cgaactgggg gaagtatgta     1380

ttactgagtg caggggccct gactgccttg atgttgataa ttttcctgat gacatgttgt     1440

agaagagtca atcgatcaga acctacgcaa cacaatctca gagggacagg gagggaggtg     1500

tcagtcactc cccaaagcgg gaagatcata tcttcatggg aatcacacaa gagtgggggt     1560

gagaccagac tgtaa                                                      1575


<210>  813
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP60 (FUG E)plasmid sequence

<400>  813
atgttcatgc cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt       60

ctcatcattt tggcaaagaa ttcgccctta ggaaagatgg ttccgcaggt tcttttgttt      120

gtactccttc tgggtttttc gttgtgtttc gggaagttcc ccatttacac gataccagac      180

gaacttggtc cctggagccc tattgacata caccatctca gctgtccaaa taacctggtt      240

gtggaggatg aaggatgtac caacctgtcc gagttctcct acatggaact caaagtggga      300

tacatctcag ccatcaaagt gaacgggttc acttgcacag gtgttgtgac agaggcagag      360

acctacacca actttgttgg ttatgtcaca accacattca agagaaagca tttccgcccc      420

accccagacg catgtagagc cgcgtataac tggaagatgg ccggtgaccc cagatatgaa      480

gagtccctac acaatccata ccccgactac cactggcttc gaactgtaag aaccaccaaa      540

gagtccctca ttatcatatc cccaagtgtg acagatttgg acccatatga caaatccctt      600

cactcaaggg tcttccctgg cggaaagtgc tcaggaataa cggtgtcctc tacctactgc      660

tcaactaacc atgattacac catttggatg cccgagaatc cgagaccaag gacaccttgt      720

gacattttta ccaatagcag agggaagaga gcatccaacg ggaacaagac ttgcggcttt      780

gtggatgaaa gaggcctgta taagtctcta aaaggagcat gcaggctcaa gttatgtgga      840

gttcttggac ttagacttat ggatggaaca tgggtcgcga tgcaaacatc agatgagacc      900

aaatggtgcc ctccagatca gttggtgaat ttgcacgact ttcgctcaga cgagatcgag      960

catctcgttg tggaggagtt agttaagaaa agagaggaat gtctggatgc attagagtcc     1020

atcatgacca ccaagtcagt aagtttcaga cgtctcagtc acctgagaaa acttgtccca     1080

gggtttggaa aagcatatac catattcaac aaaaccttga tggaggctga tgctcactac     1140

aagtcagtcc ggacctggaa tgagatcatc ccctcaaaag ggtgtttgaa agttggagga     1200

aggtgccatc ctcatgtgaa cggggtgttt ttcaatggta taatattagg gcctgacgac     1260

catgtcctaa tcccagagat gcaatcatcc ctcctccagc aacatatgga gttgttggaa     1320

tcttcagtta tccccctgat gcaccccctg gcagaccctt ctacagtttt caaagaaggt     1380

gatgaggctg aggattttgt tgaagttcac ctcgagaaaa atccaatcga gcttgtagaa     1440

ggttggttca gtagttggaa aagctctatt gcctcttttt tctttatcat agggttaatc     1500

attggactat tcttggttct ccgagttggt atccatcttt gcattaaatt aaagcacacc     1560

aagaaaagac agatttatac agacatagag atgaaccgac ttggaaagta a              1611


<210>  814
<211>  2721
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP14.1 (HSV-1 gB) plasmid sequence

<400>  814
gccaccatga ggcaaggtgc acctgccagg ggtcggagat ggtttgttgt atgggctctg       60

ctgggactga ctttgggcgt gctcgttgct tccgcagcac cctcttctcc aggaacacct      120

ggcgtggctg cagccacgca agctgctaat ggcgggccag ctaccccagc cccaccggca      180

ccaggagctc cacctactgg cgatcccaag ccaaagaaga ataagaagcc aaagccacct      240

aaaccccctc gaccagctgg tgataatgct acagtggctg caggtcatgc tacactcaga      300

gaacatctta gagatataaa agctgaaaat acagacgcta atttctatgt ctgtccccca      360

cctacaggtg caaccgttgt ccaatttgaa caacccagga gatgtcctac acgtccagaa      420

gggcagaatt ataccgaagg tatagccgtt gtgtttaaag aaaatattgc accatataaa      480

tttaaagcga cgatgtatta taaggatgtg acagtcagcc aagtatggtt tgggcatcga      540

tatagccaat tcatgggcat tttcgaagat agagcacctg taccgtttga agaagttata      600

gataaaataa atgcaaaagg cgtgtgccgt agcacagcga aatatgttcg gaataatttg      660

gaaacaacgg cattccatcg cgatgatcat gaaacagata tggaacttaa gcccgcaaat      720

gctgccacac gtacctctcg tgggtggcat actacagatc tgaaatataa tccatcacga      780

gtcgaagcat ttcatcgata tggaacaacc gtgaattgta ttgtggaaga agttgatgcc      840

agaagtgttt atccttatga tgaattcgtc ctcgcaacag gagatttcgt ttatatgtca      900

ccattctatg gatatcgtga aggtagtcat acagagcata cttcttatgc agcagatagg      960

tttaaacaag tggatggttt ctatgctcgg gatttgacta caaaagcaag agctacagcc     1020

cccacaactc gaaatcttct gaccactcct aaatttactg tagcgtggga ttgggtaccc     1080

aaacgaccat ccgtatgtac tatgacaaaa tggcaagaag tagatgaaat gcttcggtct     1140

gaatatggtg gaagctttag attttcaagt gatgcaatct ctactacatt tacaactaat     1200

ctcacagaat atcccctttc acgagtcgat ttgggagatt gtattggtaa agatgcgcgg     1260

gatgcaatgg atcggatatt tgctcgtaga tataatgcca cacatataaa agttggacaa     1320

ccacaatatt atctcgcaaa cggcgggttc ctcattgcct atcaaccgct cctttctaat     1380

actcttgccg aactctatgt ccgagagcat ctgagggaac aatcacgtaa accgccgaat     1440

ccaacacctc ctccgcctgg agcatccgcg aatgcctctg tcgaacgtat aaagacaacg     1500

tcttcaattg aatttgctag acttcaattc acctataatc atatccaaag gcacgttaat     1560

gacatgctgg gtagagtcgc aattgcttgg tgtgaattgc aaaaccatga acttacgttg     1620

tggaatgaag cacgtaaatt gaatccaaat gcaattgcta gcgcgacggt tggacgcaga     1680

gtttccgccc gaatgctggg agatgttatg gcagtttcta catgtgtccc cgtggctgcc     1740

gataatgtca tagtgcagaa ttcaatgaga atatctagcc gacctggtgc atgttattct     1800

agaccactcg tgagtttccg ctatgaggat caagggcccc tggttgaagg ccaactcgga     1860

gaaaataatg aattgcgctt gacaagggac gcaattgaac catgtacagt tggccatcgc     1920

cggtatttta catttggcgg cgggtatgtc tactttgagg aatatgccta tagtcatcaa     1980

ctttctcgtg ctgatattac aactgtgtca acatttattg atctgaatat tacgatgctt     2040

gaagaccacg aattcgtacc gttggaagtc tatacacgcc atgagataaa agattccggg     2100

cttttggatt ataccgaagt gcaacgacgg aatcaactcc atgatctccg attcgcggat     2160

attgataccg taattcatgc tgatgcaaat gctgctatgt ttgctggact tggggcattc     2220

tttgaaggaa tgggcgatct cggaagagca gttgggaaag tcgttatggg aatagttggt     2280

ggtgtcgtta gtgcggtttc aggtgtcagc agctttatga gcaatccatt cggcgccctc     2340

gcagttgggc tcctggtgct tgctgggctt gctgctgctt tctttgcttt ccggtatgtg     2400

atgaggcttc aatccaatcc aatgaaagca ctttatccct tgactactaa agaactgaag     2460

aatccgacta atcctgatgc ttcaggagaa ggggaagaag gcggggattt cgatgaagct     2520

aaactggcgg aagcacgtga aatgatccgt tatatggcat tggtcagcgc tatggaaaga     2580

accgagcata aagctaagaa gaaaggaact tctgcccttc tctctgctaa agttactgat     2640

atggtgatga gaaaacggcg taatacaaat tatactcagg taccgaataa ggatggcgat     2700

gcagatgaag atgatttgtt a                                               2721


<210>  815
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP14.2 (HSV-1 gD) plasmid sequence

<400>  815
atgggggggg ctgccgccag gttgggggcc gtgattttgt ttgtcgtcat agtgggcctc       60

catggggtcc gcagcaaata tgccttggtg gatgcctctc tcaagatggc cgaccccaat      120

cgctttcgcg gcaaagacct tccggtcctg gaccagctga ccgaccctcc gggggtccgg      180

cgcgtgtacc acatccaggc gggcctaccg gacccgttcc agccccccag cctcccgatc      240

acggtttact acgccgtgtt ggagcgcgcc tgccgcagcg tgctcctaaa cgcaccgtcg      300

gaggcccccc agattgtccg cggggcctcc gaagacgtcc ggaaacaacc ctacaacctg      360

accatcgctt ggtttcggat gggaggcaac tgtgctatcc ccatcacggt catggagtac      420

accgaatgct cctacaacaa gtctctgggg gcctgtccca tccgaacgca gccccgctgg      480

aactactatg acagcttcag cgccgtcagc gaggataacc tggggttcct gatgcacgcc      540

cccgcgtttg agaccgccgg cacgtacctg cggctcgtga agataaacga ctggacggag      600

attacacagt ttatcctgga gcaccgagcc aagggctcct gtaagtacgc cctcccgctg      660

cgcatccccc cgtcagcctg cctctccccc caggcctacc agcagggggt gacggtggac      720

agcatcggga tgctgccccg cttcatcccc gagaaccagc gcaccgtcgc cgtatacagc      780

ttgaagatcg ccgggtggca cgggcccaag gccccataca cgagcaccct gctgcccccg      840

gagctgtccg agacccccaa cgccacgcag ccagaactcg ccccggaaga ccccgaggat      900

tcggccctct tggaggaccc cgtggggacg gtggcgccgc aaatcccacc aaactggcac      960

ataccgtcga tccaggacgc cgcgacgcct taccatcccc cggccacccc gaacaacatg     1020

ggcctgatcg ccggcgcggt gggcggcagt ctcctggcag ccctggtcat ttgcggaatt     1080

gtgtactgga tgcgccgcca cactcaaaaa gccccaaagc gcatacgcct cccccacatc     1140

cgggaagacg accagccgtc ctcgcaccag cccttgtttt actta                     1185


<210>  816
<211>  2517
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP14.3 (HSV-1 gH) plasmid sequence

<400>  816
atgggaaacg gcttgtggtt tgttggtgtg ataatcctgg gagtagcctg gggccaagta       60

catgattgga cagaacaaac cgatccttgg ttcctggacg gacttgggat ggatcggatg      120

tattggcgag atacaaatac tggaagactc tggcttccta atacaccaga tcctcagaag      180

ccacccaggg gcttccttgc tccaccagat gagctcaatc ttacaacagc tagtctcccg      240

ctgctgagat ggtatgaaga acggttctgc ttcgtgctgg taacaaccgc tgaattccct      300

cgcgatccag gacaattgtt gtatattccc aaaacatatc ttctgggtcg accacccaat      360

gcctctctcc cagcacctac tacagtggaa ccaacagctc aacccccgcc gtccgtggct      420

cctctgaaag ggcttctgca taaccccgta gcatcagtct tgctccgcag tcgtgcgtgg      480

gtcacattca gcgctgtgcc cgatcctgaa gcactcactt ttcccagggg cgataatgtc      540

gccacagcat ctcatccttc tggaccacgc gacactccac cccctcgccc acctgtcggc      600

gctcgcaggc atcccacaac agaacttgat attactcatc ttcataatgc ctcaactaca      660

tggctggcta caagagggct tctgcggagc cccgggagat atgtctactt ttctccctct      720

gcttctacat ggccagttgg aatatggaca actggtgaac ttgtccttgg ttgtgacgca      780

gcacttgtca gggcccggta tggtcgcgag tttatgggac tggtcatctc aatgcatgat      840

tcaccgccag tcgaggtcat ggttgtgccg gccggtcaaa cactggaccg agtgggagat      900

cctgcagatg aaaatccacc tggcgccctg ccaggcccac ccggtggacc aaggtaccgc      960

gtgttcgtgc tcggttcact cacccgtgca gataatggta gcgccttgga tgcactgaga     1020

cgtgtcggtg ggtatcctga agaagggacc aattatgcac aatttctcag tagggcgtat     1080

gctgaattct ttagcggaga tgctggagct gaacaagggc cacggccacc cttgttttgg     1140

cggctcactg gactcctggc cacctctgga ttcgcatttg tcaatgctgc tcatgccaat     1200

ggggctgtat gtctgtctga tctcttgggg ttccttgctc atagtcgagc cctcgcaggc     1260

ctggctgctc ggggagctgc cggttgcgca gccgacagtg tcttcttcaa cgtttccgtg     1320

cttgacccga ctgcaagact tcaactggaa gcaagattgc aacatctcgt tgcagaaatc     1380

ttggaaaggg agcaatccct ggctctgcat gcactcggat accaactcgc atttgtactt     1440

gactcccctt ccgcctatga tgccgttgca ccttctgccg ctcacctgat tgatgcattg     1500

tacgcagaat tcctcggcgg aagggttctt actactccag tggtgcatag ggccttgttc     1560

tatgcttctg cggtattgag acaaccattt ctggccggag tgcctagcgc cgtccaaagg     1620

gagcgagcta ggagatcact cctgattgcc tctgcactct gcacatctga tgtagcagcc     1680

gccacaaatg ctgatctgag gactgccctc gctagagctg atcatcaaaa gacgcttttc     1740

tggctccccg atcatttcag tccttgtgca gcgtcactta gattcgacct tgatgaatca     1800

gtcttcatat tggatgcact cgcccaggca actagatctg aaacacctgt tgaggtgctc     1860

gctcaacaaa cacatggttt ggcttctaca ctcacaaggt gggcccatta taatgcattg     1920

attcgggctt ttgtgcccga agcgtcccac cgatgtggcg gacaatcagc aaatgtggaa     1980

cccaggatat tggtgcctat tacgcataat gcttcttatg tggttacgca tagcccattg     2040

ccacgcggca ttgggtataa actgacgggt gtggatgttc gcagacctct gtttctgact     2100

tatctgacag caacctgtga gggttctact cgcgacattg aaagcaaacg tctcgtaagg     2160

acgcagaatc aaagagattt gggtctggtt ggcgctgttt tcatgaggta tactcccgca     2220

ggcgaagtta tgagcgtcct gctcgtcgac accgataata cccaacaaca gattgcagcg     2280

ggccccacag aaggggctcc atcagtcttc tccagcgatg ttccttcaac cgcgctgctc     2340

ctgttcccga atggcacggt tatccacctg ttggcgttcg atacacaacc tgtcgcagcc     2400

atcgcaccgg gattcttggc tgcatccgcc ctcggggttg tgatgataac agcagctctc     2460

gcggggatac tgaaagtgct gcgcaccagc gtgcccttct tctggcgacg agagtta        2517


<210>  817
<211>  682
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP14.4 (HSV-1 gL) plasmid sequence

<400>  817
atggggattt tgggttgggt cgggcttatt gccgttgggg ttttgtgtgt gcgggggggc       60

ttgccttcaa ccgaatatgt tattcggagt cgggtggctc gagaggtggg ggatatatta      120

aaggtgcctt gtgtgccgct cccgtctgac gatcttgatt ggcgttacga gaccccctcg      180

gctataaact atgctttgat agacggtata tttttgcgtt atcactgtcc cggattggac      240

acggtcttgt gggataggca tgcccagaag gcatattggg ttaacccctt tttatttgtg      300

gcgggttttt tggaggactt gagttacccc gcgtttcctg ccaacaccca ggaaacagaa      360

acgcgcttgg ccctttataa agagatacgc caggcgctgg acagtcgcaa gcaggccgcc      420

agccacacac ctgtgaaggc tgggtgtgtg aactttgact attcgcgcac ccgccgctgt      480

gtagggcgac aggatttggg acctaccaac ggaacgtctg gacggacccc ggttctgccg      540

ccggacgatg aagcgggcct gcagccgaag cccctcacca cgccgccgcc catcatcgcc      600

acgtcggacc ccaccccgcg acgggacgcc gccacaaaaa gcagacgccg acgaccccac      660

tcccggcgcc tcttataaga tc                                               682


<210>  818
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP8 (RD114) plasmid sequence

<400>  818
atgaaactcc caacaggaat ggtcatttta tgtagcctaa taatagttcg ggcagggttt       60

gacgaccccc gcaaggctat cgcattagta caaaaacaac atggtaaacc atgcgaatgc      120

agcggagggc aggtatccga ggccccaccg aactccatcc aacaggtaac ttgcccaggc      180

aagacggcct acttaatgac caaccaaaaa tggaaatgca gagtcactcc aaaaaatctc      240

acccctagcg ggggagaact ccagaactgc ccctgtaaca ctttccagga ctcgatgcac      300

agttcttgtt atactgaata ccggcaatgc agggcgaata ataagacata ctacacggcc      360

accttgctta aaatacggtc tgggagcctc aacgaggtac agatattaca aaaccccaat      420

cagctcctac agtccccttg taggggctct ataaatcagc ccgtttgctg gagtgccaca      480

gcccccatcc atatctccga tggtggagga cccctcgata ctaagagagt gtggacagtc      540

caaaaaaggc tagaacaaat tcataaggct atgcatcctg aacttcaata ccacccctta      600

gccctgccca aagtcagaga tgaccttagc cttgatgcac ggacttttga tatcctgaat      660

accactttta ggttactcca gatgtccaat tttagccttg cccaagattg ttggctctgt      720

ttaaaactag gtacccctac ccctcttgcg atacccactc cctctttaac ctactcccta      780

gcagactccc tagcgaatgc ctcctgtcag attatacctc ccctcttggt tcaaccgatg      840

cagttctcca actcgtcctg tttatcttcc cctttcatta acgatacgga acaaatagac      900

ttaggtgcag tcacctttac taactgcacc tctgtagcca atgtcagtag tcctttatgt      960

gccctaaacg ggtcagtctt cctctgtgga aataacatgg catacaccta tttaccccaa     1020

aactggacag gactttgcgt ccaagcctcc ctcctccccg acattgacat catcccgggg     1080

gatgagccag tccccattcc tgccattgat cattatatac atagacctaa acgagctgta     1140

cagttcatcc ctttactagc tggactggga atcaccgcag cattcaccac cggagctaca     1200

ggcctaggtg tctccgtcac ccagtataca aaattatccc atcagttaat atctgatgtc     1260

caagtcttat ccggtaccat acaagattta caagaccagg tagactcgtt agctgaagta     1320

gttctccaaa ataggagggg actggaccta ctaacggcag aacaaggagg aatttgttta     1380

gccttacaag aaaaatgctg tttttatgct aacaagtcag gaattgtgag aaacaaaata     1440

agaaccctac aagaagaatt acaaaaacgc agggaaagcc tggcatccaa ccctctctgg     1500

accgggctgc agggctttct tccgtacctc ctacctctcc tgggacccct actcaccctc     1560

ctactcatac taaccattgg gccatgcgtt ttcagtcgcc tcatggcctt cattaatgat     1620

agacttaatg ttgtacatgc catggtgctg gcccagcaat accaagcact caaagctgag     1680

gaagaagctc aggattta                                                   1698


<210>  819
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP23 (HCV) plasmid sequence

<400>  819
atgggttgct ctttttctat cttcttactt gcccttctgt cgtgccttac agtgccagcg       60

tctgcggtgg aagttaggaa cgtcagttct agctactatg ccaccaatga ttgctcgaac      120

agcagcatca cctggcaact caacaacgca gttctccacc ttcctggatg cgtcccatgt      180

gagaatgata acggcacctt gcactgctgg atacaagtaa caccaaatgt ggctgtgaaa      240

caccgcggcg cgctcactca taacctgcgg acgcacgtcg atatgatcgt aatggcagct      300

acggtctgtt cggccctgta tgtgggagac atgtgcgggg ccgtgatgat tgtgtcgcag      360

gctctcataa tatcgccaga acgccacaac ttcacccaag agtgcaactg ttccatctac      420

caaggtcata tcactggcca tcgcatggca tgggacatga tgctaaactg gtcaccaact      480

cttaccatga tccttgctta tgccgctcgt gttcccgagc tagtccttga agttgtcttt      540

ggtggtcatt ggggtgtggt atttggcttg gcctatttct ccatgcaggg agcgtgggcc      600

aaggtcattg ccatcctcct tcttgttgcg ggagtggacg cagagactca taccaccggc      660

tcagctgcgg gtcatgccgc aagggggttt gccaacctcc ttagtcctgg ttccaagcaa      720

aaaataagtt tgatcaatac caatggcagc tggcacataa accggaccgc ccttaattgt      780

aatgacagct tgcagacggg tttcctcgct tctttgtttt acgtcaacaa cttcaacagc      840

tctggctgcc ccgagcgcat gtcttcctgc cgtgggctgg acgatttccg catcgggtgg      900

ggaaccctgg aatacgagac caacgtcacc aacgaggagg acatgaggcc gtactgctgg      960

cattaccctc cgaagccttg cggcattatc tcggctagga cagtttgcgg gccggtctac     1020

tgtttcactc ctagccctgt tgttgtgggt actactgacg agcagggctt gcccacctat     1080

agctgggggg aaaatgagac cgatgtcttc ctgttaaata gcacaagacc cccgcaagga     1140

gcttggttcg gctgcacttg gatgaatggg actgggttta ctaagacatg cggtgcacca     1200

ccttgccgca ttaggaggga tttcaacagc accctcgatc tactgtgccc cacagactgc     1260

tttagaaagc acccggacac cacctatctc aagtgtggag cagggccttg gttaaccccc     1320

agatgcctgg tagactaccc ttatagattg tggcattatc cgtgcaccgt aaattttacc     1380

atctttaagg tgcggatgta tgtggggggg gtggagcatc gattgtcagc agcatgcaac     1440

ttcacgcgcg gggaccgctg cagattggag gacagagata ggggtcagca gagcccactg     1500

ctgcattcca ccactgagtg ggcggtatta ccatgctctt tctccgactt accggcactg     1560

tccactggtc tattgcacct ccatcaaaat atcgtggacg tgcagtatct ctatggactt     1620

actccggcta tcacaaaata catcgtgaag tgggagtggg tggttctcct ctttttgctg     1680

ttggcagacg ccagggtctg tgcgtgcctt tggatgctca tcatattggg ccaagccgaa     1740

gcg                                                                   1743


<210>  820
<211>  2028
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP41 (EBOV) plasmid sequence

<400>  820
atgggcgtta caggaatatt gcagttacct cgtgatcgat tcaagaggac atcattcttt       60

ctttgggtaa ttatcctttt ccaaagaaca ttttccatcc cacttggagt catccacaat      120

agcacattac aggttagtga tgtcgacaaa ctagtttgtc gtgacaaact gtcatccaca      180

aatcaattga gatcagttgg actgaatctc gaagggaatg gagtggcaac tgacgtgcca      240

tctgcaacta aaagatgggg cttcaggtcc ggtgtcccac caaaggtggt caattatgaa      300

gctggtgaat gggctgaaaa ctgctacaat cttgaaatca aaaaacctga cgggagtgag      360

tgtctaccag cagcgccaga cgggattcgg ggcttccccc ggtgccggta tgtgcacaaa      420

gtatcaggaa cgggaccgtg tgccggagac tttgccttcc ataaagaggg tgctttcttc      480

ctgtatgatc gacttgcttc cacagttatc taccgaggaa cgactttcgc tgaaggtgtc      540

gttgcatttc tgatactgcc ccaagctaag aaggacttct tcagctcaca ccccttgaga      600

gagccggtca atgcaacgga ggacccgtct agtggctact attctaccac aattagatat      660

caggctaccg gttttggaac caatgagaca gagtacttgt tcgaggttga caatttgacc      720

tacgtccaac ttgaatcaag attcacacca cagtttctgc tccagctgaa tgagacaata      780

tatacaagtg ggaaaaggag caataccacg ggaaaactaa tttggaaggt caaccccgaa      840

attgatacaa caatcgggga gtgggccttc tgggaaacta aaaaaaacct cactagaaaa      900

attcgcagtg aagagttgtc tttcacagtt gtatcaaacg gagccaaaaa catcagtggt      960

cagagtccgg cgcgaacttc ttccgaccca gggaccaaca caacaactga agaccacaaa     1020

atcatggctt cagaaaattc ctctgcaatg gttcaagtgc acagtcaagg aagggaagct     1080

gcagtgtcgc atctaacaac ccttgccaca atctccacga gtccccaatc cctcacaacc     1140

aaaccaggtc cggacaacag cacccataat acacccgtgt ataaacttga catctctgag     1200

gcaactcaag ttgaacaaca tcaccgcaga acagacaacg acagcacagc ctccgacact     1260

ccctctgcca cgaccgcagc cggaccccca aaagcagaga acaccaacac gagcaagagc     1320

actgacttcc tggaccccgc caccacaaca agtccccaaa accacagcga gaccgctggc     1380

aacaacaaca ctcatcacca agataccgga gaagagagtg ccagcagcgg gaagctaggc     1440

ttaattacca atactattgc tggagtcgca ggactgatca caggcgggag aagaactcga     1500

agagaagcaa ttgtcaatgc tcaacccaaa tgcaacccta atttacatta ctggactact     1560

caggatgaag gtgctgcaat cggactggcc tggataccat atttcgggcc agcagccgag     1620

ggaatttaca tagaggggct aatgcacaat caagatggtt taatctgtgg gttgagacag     1680

ctggccaacg agacgactca agctcttcaa ctgttcctga gagccacaac tgagctacgc     1740

accttttcaa tcctcaaccg taaggcaatt gatttcttgc tgcagcgatg gggcggcaca     1800

tgccacattc tgggaccgga ctgctgtatc gaaccacatg attggaccaa gaacataaca     1860

gacaaaattg atcagattat tcatgatttt gttgataaaa cccttccgga ccagggggac     1920

aatgacaatt ggtggacagg atggagacaa tggataccgg caggtattgg agttacaggc     1980

gttataattg cagttatcgc tttattctgt atatgcaaat ttgtcttt                  2028


<210>  821
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP30 (Mokola) plasmid sequence

<400>  821
atgaatatac cttgctttgt tgtgattctc agcttagcca ctacacattc tctgggagaa       60

ttccccttgt acacaattcc tgagaagata gagaaatgga ctcccataga catgatccat      120

ctgagttgcc ccaacaacct attatctgag gaagaaggtt gcaatgcaga gtcatccttt      180

acttactttg agctcaagag tggttaccta gctcatcaga aggttccagg gtttacctgt      240

accggggtcg tgaacgaggc agagacatat acaaacttcg tcgggtacgt caccacaacc      300

ttcaaaagga agcactttag gcctacagta gccgcctgtc gtgatgccta caactggaaa      360

gtgtcaggag accccaggta cgaagagtca ctccacactc cttatcctga cagcagttgg      420

ttgaggactg tgactacaac caaagaatca cttctcataa tatcgcccag catcgtggaa      480

atggatattt acggcaggac tctccattcc cccatgtttc cttcaggagt atgttccaac      540

gtatatccct ctgtcccatc ctgtgagact aatcatgatt acacattatg gctgcctgaa      600

gatcctagtt tgagtttggt ctgtgatatc tttacttcca gcaacggaaa gaaggccatg      660

aacgggtcac gcatctgcgg attcaaggat gaaaggggat tctacagatc tttaaagggc      720

gcttgcaagc tgacattgtg tggaagacct ggaattaggt tattcgacgg aacttgggtc      780

tcttttacaa agccggacgt gcacgtatgg tgcactccca accaattgat caatatacac      840

aatgacagac tagatgagat agaacacctg atcgtggaag acatcataaa gaaaagagaa      900

gagtgcttag acaccctgga aacaatactt atgtctcaat ctgttagctt tagaaggttg      960

agccatttcc gaaagttagt tccaggatat gggaaggcct acactatttt aaacggcagc     1020

ctgatggaaa caaatgtcta ctacaaaagg gtcgacaagt gggctgacat cttaccctct     1080

aagggatgtc tgaaagtcgg gcaacaatgc atggaacctg tcaaaggagt cctcttcaat     1140

gggattatca agggcccgga tggccaaatt ttgatccccg agatgcagtc agagcagcta     1200

aagcagcata tggacctgtt gaaggcggct gtgtttcctc tccgacaccc tttaatcagc     1260

cgggaggcag tctttaagaa agacggggat gccgatgatt ttgtggatct ccatatgcct     1320

gatgtccaca agtctgtgtc agatgtcgac ctgggtctgc ctcattgggg tttctggatg     1380

ttgatcgggg caacaatagt agcatttgtg gtcttggtat gtttactccg tgtatgttgt     1440

aagagagtga ggaggagaag atcaggacgt gcaactcagg agatccccct gagctttccc     1500

tctgcccctg ttcctcgagc caaagtggtg tcatcttggg agtcctataa agggcttcca     1560

ggtacatta                                                             1569


<210>  822
<211>  9586
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pMRG103 (Gag-CasX119-PR) plasmid sequence

<400>  822
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc gccgcccgcc      720

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      780

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      840

ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc ggccgggggc     1020

ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1080

tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc     1140

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc ggggcgtggc     1200

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1260

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gccccggagc gccggcggct     1320

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1380

gacttccttt gtcccaaatc tggcggagcc gaaatctggg aggcgccgcc gcaccccctc     1440

tagcgggcgc gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc catctccagc ctcggggctg ccgcaggggg     1560

acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg     1620

gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca     1680

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attcgccacc atgggtgcga     1740

gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg ttaaggccag     1800

ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat     1860

tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc     1920

tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa     1980

ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga     2040

tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct gacacaggac     2100

acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg caaatggtac     2160

atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa gagaaggctt     2220

tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc ccacaagatt     2280

taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg ttaaaagaga     2340

ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca gggcctattg     2400

caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact agtacccttc     2460

aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa atctataaaa     2520

gatggataat cctgggatta aataaaatag taagaatgta tagccctacc agcattctgg     2580

acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc tataaaactc     2640

taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc ttgttggtcc     2700

aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga gcgacactag     2760

aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca agagttttgg     2820

ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa ggcaatttta     2880

ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac atagccaaaa     2940

attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga caccaaatga     3000

aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc cacaagggaa     3060

ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa gagagcttca     3120

ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac aaggaactgt     3180

atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa aactttagcc     3240

agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc tctagacaag     3300

agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac acaaagaagg     3360

ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct gacctgagag     3420

agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc agcaacacca     3480

gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa gccatcctgc     3540

acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga gttgctcagc     3600

ccgctcctaa gaacatcgac cagagaaagc tgatccccgt gaaggacggc aacgagagac     3660

tgacctctag cggctttgcc tgcagccagt gttgccagcc tctgtacgtg tacaagctgg     3720

aacaagtgaa cgacaagggc aagccccaca ccaactactt cggcagatgc aacgtgtccg     3780

agcacgagag gctgatcctg ctgtctcctc acaagcccga ggccaacgat gagctggtca     3840

catacagcct gggcaagttc ggacagagag ccctggactt ctacagcatc cacgtgacca     3900

gggagagcaa tcaccctgtg aagcccctgg aacagatcgg cggcaatagc tgtgcctctg     3960

gacctgtggg aaaagccctg agcgacgcct gtatgggagc cgtggcatcc ttcctgacca     4020

agtaccagga catcatcctg gaacaccaga aagtgatcaa gaagaacgag aaaagactgg     4080

ccaacctcaa ggatatcgcc agcgctaacg gcctggcctt tcctaagatc accctgcctc     4140

cacagcctca caccaaagag ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga     4200

tttgggtcaa cctgaatctg tggcagaagc tgaagatcgg cagggacgaa gccaagccac     4260

tgcagagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg     4320

attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca     4380

aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga     4440

gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagttc ggcgacctgc     4500

tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg     4560

agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa     4620

ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct     4680

ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc     4740

tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca     4800

tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg     4860

gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt     4920

tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa     4980

agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta     5040

tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga     5100

gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca     5160

acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag     5220

aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcatcgac cggggcgaga     5280

atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg     5340

actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga     5400

ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac tctaggaagt     5460

acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc     5520

tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg     5580

gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc     5640

tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc     5700

agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca     5760

gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag     5820

agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga     5880

aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca     5940

gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca     6000

gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac     6060

aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt     6120

accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga     6180

gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga     6240

agagaaaggt agccctcgag tacccatatg atgtccctga ctacgcttcc tttagcttcc     6300

ctcagatcac tctttggcag cgacccctcg tcacaataaa gatagggggg caattaaagg     6360

aagctctatt agatacagga gcagatgata cagtattaga agaaatgaat ttgccaggaa     6420

gatggaaacc aaaaatgata gggggaattg gaggttttat caaagtaaga cagtatgatc     6480

agatactcat agaaatctgc ggacataaag ctataggtac agtattagta ggacctacac     6540

ctgtcaacat aattggaaga aatctgttga ctcagattgg ctgcacttta aatttttgac     6600

tagcagatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     6660

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     6720

gtctctcact cggaaggaca tatgggaggg caaatcattt aaaacatcag aatgagtatt     6780

tggtttagag tttggcaaca tatgcccata tgctggctgc catgaacaaa ggttggctat     6840

aaagaggtca tcagtatatg aaacagcccc ctgctgtcca ttccttattc catagaaaag     6900

ccttgacttg aggttagatt ttttttatat tttgttttgt gttatttttt tctttaacat     6960

ccctaaaatt ttccttacat gttttactag ccagattttt cctcctctcc tgactactcc     7020

cagtcatagc tgtccctctt ctcttatgaa gatccctcga cctgcagccc aagcttggcg     7080

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     7140

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     7200

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagcggatc     7260

cgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa     7320

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag     7380

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag     7440

gcctaggctt ttgcaaaaag ctaacttgtt tattgcagct tataatggtt acaaataaag     7500

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt     7560

gtccaaactc atcaatgtat cttatcatgt ctggatccgc tgcattaatg aatcggccaa     7620

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     7680

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     7740

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     7800

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     7860

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     7920

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     7980

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca atgctcacgc     8040

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     8100

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     8160

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     8220

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca     8280

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     8340

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     8400

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     8460

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     8520

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     8580

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     8640

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     8700

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     8760

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     8820

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     8880

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     8940

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     9000

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     9060

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     9120

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     9180

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     9240

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     9300

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     9360

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     9420

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     9480

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     9540

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctg                    9586


<210>  823
<211>  9586
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pMRG103 (Gag-CasX438-PR) plasmid sequence

<400>  823
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc gccgcccgcc      720

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      780

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      840

ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc ggccgggggc     1020

ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1080

tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc     1140

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc ggggcgtggc     1200

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1260

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gccccggagc gccggcggct     1320

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1380

gacttccttt gtcccaaatc tggcggagcc gaaatctggg aggcgccgcc gcaccccctc     1440

tagcgggcgc gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc catctccagc ctcggggctg ccgcaggggg     1560

acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg     1620

gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca     1680

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attcgccacc atgggtgcga     1740

gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg ttaaggccag     1800

ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat     1860

tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc     1920

tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa     1980

ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga     2040

tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct gacacaggac     2100

acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg caaatggtac     2160

atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa gagaaggctt     2220

tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc ccacaagatt     2280

taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg ttaaaagaga     2340

ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca gggcctattg     2400

caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact agtacccttc     2460

aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa atctataaaa     2520

gatggataat cctgggatta aataaaatag taagaatgta tagccctacc agcattctgg     2580

acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc tataaaactc     2640

taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc ttgttggtcc     2700

aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga gcgacactag     2760

aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca agagttttgg     2820

ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa ggcaatttta     2880

ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac atagccaaaa     2940

attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga caccaaatga     3000

aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc cacaagggaa     3060

ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa gagagcttca     3120

ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac aaggaactgt     3180

atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa aactttagcc     3240

agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc tctagacaag     3300

agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac acaaagaagg     3360

ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct gacctgagag     3420

agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc agcaacacca     3480

gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa gccatcctgc     3540

acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga gttgctcagc     3600

ccgctcctaa gaacatcgac cagagaaagc tgatccccgt gaaggacggc aacgagagac     3660

tgacctctag cggctttgcc tgcagccagt gttgccagcc tctgtacgtg tacaagctgg     3720

aacaagtgaa cgacaagggc aagccccaca ccaactactt cggcagatgc aacgtgtccg     3780

agcacgagag gctgatcctg ctgtctcctc acaagcccga ggccaacgat gagctggtca     3840

catacagcct gggcaagttc ggacagagag ccctggactt ctacagcatc cacgtgacca     3900

gggagagcaa tcaccctgtg aagcccctgg aacagatcgg cggcaatagc tgtgcctctg     3960

gacctgtggg aaaagccctg agcgacgcct gtatgggagc cgtggcatcc ttcctgacca     4020

agtaccagga catcatcctg gaacaccaga aagtgatcaa gaagaacgag aaaagactgg     4080

ccaacctcaa ggatatcgcc agcgctaacg gcctggcctt tcctaagatc accctgcctc     4140

cacagcctca caccaaagag ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga     4200

tttgggtcaa cctgaatctg tggcagaagc tgaagatcgg cagggacgaa gccaagccac     4260

tgcagagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg     4320

attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca     4380

aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga     4440

gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg ggcgacctgc     4500

tgaagcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg     4560

agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa     4620

ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct     4680

ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc     4740

tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca     4800

tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg     4860

gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt     4920

tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa     4980

agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta     5040

tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga     5100

gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca     5160

acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag     5220

aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac cggggcgaga     5280

atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg     5340

actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga     5400

ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac tctaggaagt     5460

acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc     5520

tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg     5580

gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc     5640

tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc     5700

agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca     5760

gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag     5820

agctgaaggt tgagggccag atcacctact acaacaggag gaagaggcag aacgtcgtga     5880

aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca     5940

gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca     6000

gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac     6060

aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt     6120

accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga     6180

gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga     6240

agagaaaggt agccctcgag tacccatatg atgtccctga ctacgcttcc tttagcttcc     6300

ctcagatcac tctttggcag cgacccctcg tcacaataaa gatagggggg caattaaagg     6360

aagctctatt agatacagga gcagatgata cagtattaga agaaatgaat ttgccaggaa     6420

gatggaaacc aaaaatgata gggggaattg gaggttttat caaagtaaga cagtatgatc     6480

agatactcat agaaatctgc ggacataaag ctataggtac agtattagta ggacctacac     6540

ctgtcaacat aattggaaga aatctgttga ctcagattgg ctgcacttta aatttttgac     6600

tagcagatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     6660

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     6720

gtctctcact cggaaggaca tatgggaggg caaatcattt aaaacatcag aatgagtatt     6780

tggtttagag tttggcaaca tatgcccata tgctggctgc catgaacaaa ggttggctat     6840

aaagaggtca tcagtatatg aaacagcccc ctgctgtcca ttccttattc catagaaaag     6900

ccttgacttg aggttagatt ttttttatat tttgttttgt gttatttttt tctttaacat     6960

ccctaaaatt ttccttacat gttttactag ccagattttt cctcctctcc tgactactcc     7020

cagtcatagc tgtccctctt ctcttatgaa gatccctcga cctgcagccc aagcttggcg     7080

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     7140

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     7200

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagcggatc     7260

cgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa     7320

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag     7380

aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag     7440

gcctaggctt ttgcaaaaag ctaacttgtt tattgcagct tataatggtt acaaataaag     7500

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt     7560

gtccaaactc atcaatgtat cttatcatgt ctggatccgc tgcattaatg aatcggccaa     7620

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     7680

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     7740

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     7800

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     7860

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     7920

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     7980

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca atgctcacgc     8040

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     8100

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     8160

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     8220

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca     8280

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     8340

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     8400

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     8460

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     8520

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     8580

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     8640

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     8700

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     8760

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     8820

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     8880

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     8940

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     9000

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     9060

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     9120

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     9180

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     9240

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     9300

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     9360

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     9420

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     9480

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     9540

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctg                    9586


<210>  824
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  824
gtgtagtaca agagatagaa                                                   20


<210>  825
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  825
ctgcattcta gttgtggttt                                                   20


<210>  826
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  826
ggccgagatg tctcgctccg                                                   20


<210>  827
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  827
cgagacgtaa ttacgtctcg                                                   20


<210>  828
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence encoding gRNA

<400>  828
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagc tgcattctag ttgtggttt                  109


<210>  829
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sequence encoding gRNA

<400>  829
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagc gagacgtaat tacgtctcg                  109


<210>  830
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 glycoprotein

<400>  830
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  831
<211>  4560
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid sequence

<400>  831
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560


<210>  832
<211>  4620
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-(-1)-POL plasmid sequence

<400>  832
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccagta aaattaaagc     1800

caggaatgga tggcccaaaa gttaaacaat ggccattgac agaagaaaaa ataaaagcat     1860

tagtagaaat ttgtacagaa atggaaaagg aaggaaaaat ttcaaaaatt gggcctgaaa     1920

atccatacaa tactccagta tttgccataa agaaaaaaga cagtactaaa tggagaaaat     1980

tagtagattt cagagaactt aataagagaa ctcaagattt ctgggaagtt caattaggaa     2040

taccacatcc tgcagggtta aaacagaaaa aatcagtaac agtactggat gtgggcgatg     2100

catatttttc agttccctta gataaagact tcaggaagta tactgcattt accataccta     2160

gtataaacaa tgagacacca gggattagat atcagtacaa tgtgcttcca cagggatgga     2220

aaggatcacc agcaatattc cagtgtagca tgacaaaaat cttagagcct tttagaaaac     2280

aaaatccaga catagtcatc tatcaataca tggatgattt gtatgtagga tctgacttag     2340

aaatagggca gcatagaaca aaaatagagg aactgagaca acatctgttg aggtggggat     2400

ttaccacacc agacaaaaaa catcagaaag aacctccatt cctttggatg ggttatgaac     2460

tccatcctga taaatggaca gtacagccta tagtgctgcc agaaaaggac agctggactg     2520

tcaatgacat acagaaatta gtgggaaaat tgaattgggc aagtcagatt tatgcaggga     2580

ttaaagtaag gcaattatgt aaacttctta ggggaaccaa agcactaaca gaagtagtac     2640

cactaacaga agaagcagag ctagaactgg cagaaaacag ggagattcta aaagaaccgg     2700

tacatggagt gtattatgac ccatcaaaag acttaatagc agaaatacag aagcaggggc     2760

aaggccaatg gacatatcaa atttatcaag agccatttaa aaatctgaaa acaggaaagt     2820

atgcaagaat gaagggtgcc cacactaatg atgtgaaaca attaacagag gcagtacaaa     2880

aaatagccac agaaagcata gtaatatggg gaaagactcc taaatttaaa ttacccatac     2940

aaaaggaaac atgggaagca tggtggacag agtattggca agccacctgg attcctgagt     3000

gggagtttgt caatacccct cccttagtga agttatggta ccagttagag aaagaaccca     3060

taataggagc agaaactttc tatgtagatg gggcagccaa tagggaaact aaattaggaa     3120

aagcaggata tgtaactgac agaggaagac aaaaagttgt ccccctaacg gacacaacaa     3180

atcagaagac tgagttacaa gcaattcatc tagctttgca ggattcggga ttagaagtaa     3240

acatagtgac agactcacaa tatgcattgg gaatcattca agcacaacca gataagagtg     3300

aatcagagtt agtcagtcaa ataatagagc agttaataaa aaaggaaaaa gtctacctgg     3360

catgggtacc agcacacaaa ggaattggag gaaatgaaca agtagataaa ttggtcagtg     3420

ctggaatcag gaaagtacta tttttagatg gaatagataa ggcccaagaa gaacatgaga     3480

aatatcacag taattggaga gcaatggcta gtgattttaa cctaccacct gtagtagcaa     3540

aagaaatagt agccagctgt gataaatgtc agctaaaagg ggaagccatg catggacaag     3600

tagactgtag cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct     3660

tggtagcagt tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag     3720

ggcaagaaac agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac     3780

atacagacaa tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg     3840

ggatcaagca ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta     3900

tgaataaaga attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga     3960

cagcagtaca aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt     4020

acagtgcagg ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac     4080

aaaaacaaat tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag     4140

tttggaaagg accagcaaag ctcctctgga aaggtgaagg ggcagtagta atacaagata     4200

atagtgacat aaaagtagtg ccaagaagaa aagcaaagat catcagggat tatggaaaac     4260

agatggcagg tgatgattgt gtggcaagta gacaggatga ggattaacac atggaattct     4320

gcaacaactg ctgtttatcc atttcagaat tgggtgtcga catagcagaa taggcgttac     4380

tcgacagagg agagcaagaa atggagccag tagatcctag actagagccc tggaagcatc     4440

caggaagtca gcctaaaact gcttgtacca attgctattg taaaaagtgt tgctttcatt     4500

gccaagtttg tttcatgaca aaagccttag gcatctccta tggcaggaag aagcggagac     4560

agcgacgaag agctcatcag aacagtcaga ctcatcaagc ttctctatca aagcagtaag     4620


<210>  833
<211>  4805
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-(-1)-X-PR plasmid sequence

<400>  833
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccaaag aagaagcgga     1800

aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg gtcaaggaca     1860

gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc agagtgatga     1920

cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac atccctcagc     1980

ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac accgagatga     2040

agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg ggcctgatga     2100

gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag cccgagatgg     2160

acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc cagcctctgt     2220

tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac tacttcggca     2280

gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa cctgagaagg     2340

actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc ctggacttct     2400

acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct cagatcgccg     2460

gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc atgggaacaa     2520

tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag gtggtcaagg     2580

gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac ctggaatacc     2640

ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc tacaacgaag     2700

tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg aaactgtcca     2760

gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct ctggtggaaa     2820

gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag ctgatcaacg     2880

agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag agacaagaag     2940

ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag ttcgccagat     3000

accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac tggggcaaag     3060

tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc aagcacatta     3120

agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg accgattggc     3180

tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag gacgagttct     3240

gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag cccttcgcca     3300

ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac aactgcgcct     3360

tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc aattacttca     3420

aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct aacagattct     3480

acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac ttcaacttcg     3540

acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc agagagttca     3600

tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat ggcagagtga     3660

tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg tttgtggccc     3720

tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg aacctgatcg     3780

gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct gaaggatgcc     3840

cactgagcag attcaaggac tccctgggca accctacaca catcctgaga atcggcgaga     3900

gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag agaagagccg     3960

gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac atggtccgaa     4020

acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg atcttcgaga     4080

atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag aggcagtaca     4140

ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc aagacctacc     4200

tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc ttcaccatca     4260

ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc ggctggatga     4320

ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac aacaggtaca     4380

agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc gaagagagcg     4440

tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg agcctgctga     4500

agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac tgcggcttcg     4560

agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg ttcctgagaa     4620

gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac aagagggcct     4680

ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg aagcccgccg     4740

tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat gtccctgact     4800

acgct                                                                 4805


<210>  834
<211>  4869
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X-PR plasmid sequence

<400>  834
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560

tcctttagct tccctcagat cactctttgg cagcgacccc tcgtcacaat aaagataggg     4620

gggcaattaa aggaagctct attagataca ggagcagatg atacagtatt agaagaaatg     4680

aatttgccag gaagatggaa accaaaaatg atagggggaa ttggaggttt tatcaaagta     4740

agacagtatg atcagatact catagaaatc tgcggacata aagctatagg tacagtatta     4800

gtaggaccta cacctgtcaa cataattgga agaaatctgt tgactcagat tggctgcact     4860

ttaaatttt                                                             4869


<210>  835
<211>  4560
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid sequence

<400>  835
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560


<210>  836
<211>  4560
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-X plasmid sequence

<400>  836
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560


<210>  837
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  837
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  838
<211>  4338
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-X (no p1/p6) plasmid sequence

<400>  838
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagac cggtgcccca     1320

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1380

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1440

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1500

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1560

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1620

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1680

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1740

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1800

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     1860

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     1920

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     1980

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2040

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2100

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2160

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2220

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2280

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2340

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2400

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2460

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2520

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2580

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2640

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2700

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2760

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     2820

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     2880

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     2940

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3000

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3060

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3120

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3180

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3240

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3300

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3360

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3420

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3480

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3540

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3600

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3660

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3720

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3780

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     3840

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     3900

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     3960

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4020

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4080

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4140

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4200

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4260

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4320

gatgtccctg actacgct                                                   4338


<210>  839
<211>  4395
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1-X plasmid sequence

<400>  839
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaaccgg tgccccaaag     1380

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1440

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1500

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1560

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1620

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1680

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1740

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     1800

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     1860

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     1920

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     1980

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2040

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2100

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2160

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     2220

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2280

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2340

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2400

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2460

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2520

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2580

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2640

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2700

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     2760

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     2820

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     2880

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     2940

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3000

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3060

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3120

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3180

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3240

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3300

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3360

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3420

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3480

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3540

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3600

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3660

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3720

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     3780

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     3840

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     3900

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     3960

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4020

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4080

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4140

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4200

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4260

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4320

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4380

gtccctgact acgct                                                      4395


<210>  840
<211>  4814
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-X-(-1)-PR plasmid sequence

<400>  840
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaatttct tagggaagac cggtgcccca     1320

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1380

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1440

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1500

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1560

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1620

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1680

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1740

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1800

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     1860

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     1920

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     1980

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2040

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2100

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2160

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2220

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2280

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2340

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2400

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2460

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2520

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2580

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2640

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2700

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2760

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     2820

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     2880

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     2940

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3000

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3060

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3120

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3180

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3240

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3300

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3360

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3420

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3480

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3540

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3600

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3660

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3720

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3780

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     3840

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     3900

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     3960

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4020

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4080

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4140

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4200

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4260

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4320

gatgtccctg actacgctag acaggctaat tttttaggga agatctggcc ttcccacaag     4380

ggaaggccag ggaattttct tcagagcaga ccagagccaa cagccccacc agaagagagc     4440

ttcaggtttg gggaagagac aacaactccc tctcagaagc aggagccgat agacaaggaa     4500

ctgtatcctt tagcttccct cagatcactc tttggcagcg acccctcgtc acaataaaga     4560

taggggggca attaaaggaa gctctattag atacaggagc agatgataca gtattagaag     4620

aaatgaattt gccaggaaga tggaaaccaa aaatgatagg gggaattgga ggttttatca     4680

aagtaagaca gtatgatcag atactcatag aaatctgcgg acataaagct ataggtacag     4740

tattagtagg acctacacct gtcaacataa ttggaagaaa tctgttgact cagattggct     4800

gcactttaaa tttt                                                       4814


<210>  841
<211>  4649
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X-(-1)-PR plasmid sequence

<400>  841
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gctagacagg ctaatttttt agggaagatc     4200

tggccttccc acaagggaag gccagggaat tttcttcaga gcagaccaga gccaacagcc     4260

ccaccagaag agagcttcag gtttggggaa gagacaacaa ctccctctca gaagcaggag     4320

ccgatagaca aggaactgta tcctttagct tccctcagat cactctttgg cagcgacccc     4380

tcgtcacaat aaagataggg gggcaattaa aggaagctct attagataca ggagcagatg     4440

atacagtatt agaagaaatg aatttgccag gaagatggaa accaaaaatg atagggggaa     4500

ttggaggttt tatcaaagta agacagtatg atcagatact catagaaatc tgcggacata     4560

aagctatagg tacagtatta gtaggaccta cacctgtcaa cataattgga agaaatctgt     4620

tgactcagat tggctgcact ttaaatttt                                       4649


<210>  842
<211>  4151
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-NC-(-1)-PR

<400>  842
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct gggggacccg gccataaagc aagagttttg     3480

gctgaagcaa tgagccaagt aacaaatcca gctaccataa tgatacagaa aggcaatttt     3540

aggaaccaaa gaaagactgt taagtgtttc aattgtggca aagaagggca catagccaaa     3600

aattgcaggg cccctaggaa aaagggctgt tggaaatgtg gaaaggaagg acaccaaatg     3660

aaagattgta ctgagagaca ggctaatttt ttagggaaga tctggccttc ccacaaggga     3720

aggccaggga attttcttca gagcagacca gagccaacag ccccaccaga agagagcttc     3780

aggtttgggg aagagacaac aactccctct cagaagcagg agccgataga caaggaactg     3840

tatcctttag cttccctcag atcactcttt ggcagcgacc cctcgtcaca ataaagatag     3900

gggggcaatt aaaggaagct ctattagata caggagcaga tgatacagta ttagaagaaa     3960

tgaatttgcc aggaagatgg aaaccaaaaa tgataggggg aattggaggt tttatcaaag     4020

taagacagta tgatcagata ctcatagaaa tctgcggaca taaagctata ggtacagtat     4080

tagtaggacc tacacctgtc aacataattg gaagaaatct gttgactcag attggctgca     4140

ctttaaattt t                                                          4151


<210>  843
<211>  3926
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-(-1)-PR plasmid sequence

<400>  843
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct agacaggcta attttttagg gaagatctgg     3480

ccttcccaca agggaaggcc agggaatttt cttcagagca gaccagagcc aacagcccca     3540

ccagaagaga gcttcaggtt tggggaagag acaacaactc cctctcagaa gcaggagccg     3600

atagacaagg aactgtatcc tttagcttcc ctcagatcac tctttggcag cgacccctcg     3660

tcacaataaa gatagggggg caattaaagg aagctctatt agatacagga gcagatgata     3720

cagtattaga agaaatgaat ttgccaggaa gatggaaacc aaaaatgata gggggaattg     3780

gaggttttat caaagtaaga cagtatgatc agatactcat agaaatctgc ggacataaag     3840

ctataggtac agtattagta ggacctacac ctgtcaacat aattggaaga aatctgttga     3900

ctcagattgg ctgcacttta aatttt                                          3926


<210>  844
<211>  3759
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-PR plasmid sequence

<400>  844
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct tcctttagct tccctcagat cactctttgg     3480

cagcgacccc tcgtcacaat aaagataggg gggcaattaa aggaagctct attagataca     3540

ggagcagatg atacagtatt agaagaaatg aatttgccag gaagatggaa accaaaaatg     3600

atagggggaa ttggaggttt tatcaaagta agacagtatg atcagatact catagaaatc     3660

tgcggacata aagctatagg tacagtatta gtaggaccta cacctgtcaa cataattgga     3720

agaaatctgt tgactcagat tggctgcact ttaaatttt                            3759


<210>  845
<211>  4482
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X-PR plasmid sequence

<400>  845
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gcttccttta gcttccctca gatcactctt     4200

tggcagcgac ccctcgtcac aataaagata ggggggcaat taaaggaagc tctattagat     4260

acaggagcag atgatacagt attagaagaa atgaatttgc caggaagatg gaaaccaaaa     4320

atgatagggg gaattggagg ttttatcaaa gtaagacagt atgatcagat actcatagaa     4380

atctgcggac ataaagctat aggtacagta ttagtaggac ctacacctgt caacataatt     4440

ggaagaaatc tgttgactca gattggctgc actttaaatt tt                        4482


<210>  846
<211>  3450
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X plasmid sequence

<400>  846
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct                                      3450


<210>  847
<211>  4173
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X plasmid sequence

<400>  847
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gct                                  4173


<210>  848
<211>  4338
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-X plasmid sequence

<400>  848
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagac cggtgcccca     1320

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1380

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1440

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1500

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1560

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1620

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1680

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1740

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1800

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     1860

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     1920

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     1980

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2040

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2100

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2160

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2220

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2280

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2340

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2400

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2460

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2520

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2580

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2640

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2700

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2760

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     2820

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     2880

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     2940

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3000

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3060

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3120

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3180

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3240

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3300

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3360

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3420

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3480

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3540

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3600

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3660

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3720

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3780

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     3840

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     3900

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     3960

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4020

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4080

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4140

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4200

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4260

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4320

gatgtccctg actacgct                                                   4338


<210>  849
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  849
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  850
<211>  4395
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1-X plasmid sequence

<400>  850
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaaccgg tgccccaaag     1380

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1440

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1500

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1560

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1620

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1680

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1740

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     1800

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     1860

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     1920

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     1980

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2040

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2100

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2160

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     2220

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2280

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2340

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2400

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2460

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2520

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2580

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2640

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2700

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     2760

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     2820

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     2880

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     2940

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3000

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3060

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3120

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3180

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3240

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3300

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3360

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3420

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3480

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3540

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3600

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3660

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3720

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     3780

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     3840

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     3900

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     3960

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4020

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4080

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4140

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4200

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4260

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4320

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4380

gtccctgact acgct                                                      4395


<210>  851
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  851
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  852
<211>  4814
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-X-(-1)-PR plasmid sequence

<400>  852
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaatttct tagggaagac cggtgcccca     1320

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1380

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1440

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1500

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1560

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1620

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1680

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1740

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1800

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     1860

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     1920

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     1980

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2040

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2100

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2160

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2220

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2280

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2340

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2400

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2460

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2520

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2580

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2640

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2700

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2760

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     2820

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     2880

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     2940

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3000

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3060

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3120

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3180

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3240

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3300

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3360

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3420

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3480

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3540

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3600

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3660

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3720

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3780

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     3840

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     3900

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     3960

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4020

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4080

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4140

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4200

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4260

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4320

gatgtccctg actacgctag acaggctaat tttttaggga agatctggcc ttcccacaag     4380

ggaaggccag ggaattttct tcagagcaga ccagagccaa cagccccacc agaagagagc     4440

ttcaggtttg gggaagagac aacaactccc tctcagaagc aggagccgat agacaaggaa     4500

ctgtatcctt tagcttccct cagatcactc tttggcagcg acccctcgtc acaataaaga     4560

taggggggca attaaaggaa gctctattag atacaggagc agatgataca gtattagaag     4620

aaatgaattt gccaggaaga tggaaaccaa aaatgatagg gggaattgga ggttttatca     4680

aagtaagaca gtatgatcag atactcatag aaatctgcgg acataaagct ataggtacag     4740

tattagtagg acctacacct gtcaacataa ttggaagaaa tctgttgact cagattggct     4800

gcactttaaa tttt                                                       4814


<210>  853
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  853
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  854
<211>  4649
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X-(-1)-PR plasmid sequence

<400>  854
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gctagacagg ctaatttttt agggaagatc     4200

tggccttccc acaagggaag gccagggaat tttcttcaga gcagaccaga gccaacagcc     4260

ccaccagaag agagcttcag gtttggggaa gagacaacaa ctccctctca gaagcaggag     4320

ccgatagaca aggaactgta tcctttagct tccctcagat cactctttgg cagcgacccc     4380

tcgtcacaat aaagataggg gggcaattaa aggaagctct attagataca ggagcagatg     4440

atacagtatt agaagaaatg aatttgccag gaagatggaa accaaaaatg atagggggaa     4500

ttggaggttt tatcaaagta agacagtatg atcagatact catagaaatc tgcggacata     4560

aagctatagg tacagtatta gtaggaccta cacctgtcaa cataattgga agaaatctgt     4620

tgactcagat tggctgcact ttaaatttt                                       4649


<210>  855
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  855
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  856
<211>  4151
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-NC-(-1)-PR plasmid sequence

<400>  856
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct gggggacccg gccataaagc aagagttttg     3480

gctgaagcaa tgagccaagt aacaaatcca gctaccataa tgatacagaa aggcaatttt     3540

aggaaccaaa gaaagactgt taagtgtttc aattgtggca aagaagggca catagccaaa     3600

aattgcaggg cccctaggaa aaagggctgt tggaaatgtg gaaaggaagg acaccaaatg     3660

aaagattgta ctgagagaca ggctaatttt ttagggaaga tctggccttc ccacaaggga     3720

aggccaggga attttcttca gagcagacca gagccaacag ccccaccaga agagagcttc     3780

aggtttgggg aagagacaac aactccctct cagaagcagg agccgataga caaggaactg     3840

tatcctttag cttccctcag atcactcttt ggcagcgacc cctcgtcaca ataaagatag     3900

gggggcaatt aaaggaagct ctattagata caggagcaga tgatacagta ttagaagaaa     3960

tgaatttgcc aggaagatgg aaaccaaaaa tgataggggg aattggaggt tttatcaaag     4020

taagacagta tgatcagata ctcatagaaa tctgcggaca taaagctata ggtacagtat     4080

tagtaggacc tacacctgtc aacataattg gaagaaatct gttgactcag attggctgca     4140

ctttaaattt t                                                          4151


<210>  857
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  857
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  858
<211>  3926
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-(-1)-PR plasmid sequence

<400>  858
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct agacaggcta attttttagg gaagatctgg     3480

ccttcccaca agggaaggcc agggaatttt cttcagagca gaccagagcc aacagcccca     3540

ccagaagaga gcttcaggtt tggggaagag acaacaactc cctctcagaa gcaggagccg     3600

atagacaagg aactgtatcc tttagcttcc ctcagatcac tctttggcag cgacccctcg     3660

tcacaataaa gatagggggg caattaaagg aagctctatt agatacagga gcagatgata     3720

cagtattaga agaaatgaat ttgccaggaa gatggaaacc aaaaatgata gggggaattg     3780

gaggttttat caaagtaaga cagtatgatc agatactcat agaaatctgc ggacataaag     3840

ctataggtac agtattagta ggacctacac ctgtcaacat aattggaaga aatctgttga     3900

ctcagattgg ctgcacttta aatttt                                          3926


<210>  859
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  859
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  860
<211>  3759
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X-PR plasmid sequence

<400>  860
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct tcctttagct tccctcagat cactctttgg     3480

cagcgacccc tcgtcacaat aaagataggg gggcaattaa aggaagctct attagataca     3540

ggagcagatg atacagtatt agaagaaatg aatttgccag gaagatggaa accaaaaatg     3600

atagggggaa ttggaggttt tatcaaagta agacagtatg atcagatact catagaaatc     3660

tgcggacata aagctatagg tacagtatta gtaggaccta cacctgtcaa cataattgga     3720

agaaatctgt tgactcagat tggctgcact ttaaatttt                            3759


<210>  861
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  861
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  862
<211>  4482
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X-PR plasmid sequence

<400>  862
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gcttccttta gcttccctca gatcactctt     4200

tggcagcgac ccctcgtcac aataaagata ggggggcaat taaaggaagc tctattagat     4260

acaggagcag atgatacagt attagaagaa atgaatttgc caggaagatg gaaaccaaaa     4320

atgatagggg gaattggagg ttttatcaaa gtaagacagt atgatcagat actcatagaa     4380

atctgcggac ataaagctat aggtacagta ttagtaggac ctacacctgt caacataatt     4440

ggaagaaatc tgttgactca gattggctgc actttaaatt tt                        4482


<210>  863
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  863
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  864
<211>  3450
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-X plasmid sequence

<400>  864
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

accggtgccc caaagaagaa gcggaaggtc tctagacaag agatcaagag aatcaacaag      480

atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac aggccccatg      540

aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga aaacctgaga      600

aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa cctgaacaag      660

ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg ggaagagttc      720

cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa gaagatcgac      780

cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc cggctttgcc      840

tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc cgagaaaggc      900

aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa gctgattctg      960

ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag cctgggcaag     1020

tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag cacacacccc     1080

gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt gggcaaagcc     1140

ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca ggacatcatc     1200

atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct gagggagctg     1260

gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc tcacacaaaa     1320

gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt caacctgaac     1380

ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag actgaagggc     1440

ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg ggacatggtc     1500

tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt ctggcagaac     1560

ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga agaggaccgg     1620

aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca cctggaaaag     1680

aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat cgacaagaag     1740

gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga ggacgcccaa     1800

tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat cgagggcctg     1860

aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa gtggtacggc     1920

gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga catcagcggc     1980

ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa gaaactgaac     2040

ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa gatcaaaccc     2100

gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg cgagatcgtg     2160

cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc tctggccttc     2220

ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga aaccggctct     2280

ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag aaccagacag     2340

gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct ggacagcagc     2400

aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc tgctgtgatc     2460

gccctgacag accctgaagg atgcccactg agcagattca aggactccct gggcaaccct     2520

acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat ccaggccaag     2580

aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag caaggccaag     2640

aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta cgccgtgaca     2700

caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca gggcaagaga     2760

acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc taaactggcc     2820

tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac ctccaagacc     2880

tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct ggaaaagctc     2940

aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa ggttgagggc     3000

cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct gagcgtggaa     3060

ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac aaagggcaga     3120

tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt gcaagagaag     3180

ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc cctgaacatt     3240

gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac caacaagacc     3300

accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta cagaaaaaag     3360

ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa ggtagccctc     3420

gagtacccat atgatgtccc tgactacgct                                      3450


<210>  865
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  865
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  866
<211>  4173
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X plasmid sequence

<400>  866
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gct                                  4173


<210>  867
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6 plasmid sequence

<400>  867
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taa                                                                   1503


<210>  868
<211>  4356
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-P1/P6-X plasmid sequence

<400>  868
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgt ttttagggaa gatctggcct tcccacaagg gaaggccagg gaattttctt     1140

cagagcagac cagagccaac agccccacca gaagagagct tcaggtttgg ggaagagaca     1200

acaactccct ctcagaagca ggagccgata gacaaggaac tgtatccttt agcttccctc     1260

agatcactct ttggcagcga cccctcgtca caaaacttta gccagaacta tccgattgtg     1320

cagaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1380

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1440

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1500

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1560

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1620

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1680

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1740

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1800

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1860

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1920

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1980

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     2040

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     2100

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     2160

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2220

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2280

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2340

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2400

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2460

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2520

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2580

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2640

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2700

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2760

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2820

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2880

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2940

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     3000

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     3060

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     3120

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3180

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3240

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3300

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3360

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3420

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3480

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3540

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3600

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3660

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3720

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3780

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3840

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3900

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3960

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     4020

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     4080

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     4140

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4200

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4260

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4320

ctcgagtacc catatgatgt ccctgactac gcttga                               4356


<210>  869
<211>  4677
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-P1/P6-P1/P6-X plasmid sequence

<400>  869
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggctttttag ggaagatctg gccttcccac aagggaaggc cagggaattt tcttcagagc     1200

agaccagagc caacagcccc accagaagag agcttcaggt ttggggaaga gacaacaact     1260

ccctctcaga agcaggagcc gatagacaag gaactgtatc ctttagcttc cctcagatca     1320

ctctttggca gcgacccctc gtcacaaaac tttagccaga actatccgat tgtgcagacc     1380

ggtgccccaa agaagaagcg gaaggtctct agatttttag ggaagatctg gccttcccac     1440

aagggaaggc cagggaattt tcttcagagc agaccagagc caacagcccc accagaagag     1500

agcttcaggt ttggggaaga gacaacaact ccctctcaga agcaggagcc gatagacaag     1560

gaactgtatc ctttagcttc cctcagatca ctctttggca gcgacccctc gtcacaaaac     1620

tttagccaga actatccgat tgtgcagacc ggtgccccaa agaagaagcg gaaggtctct     1680

agacaagaga tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca     1740

aagaaggccg gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac     1800

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc     1860

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc     1920

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt     1980

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag     2040

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac     2100

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac     2160

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat     2220

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc     2280

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga     2340

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc     2400

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag     2460

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg     2520

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc     2580

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac     2640

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     2700

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     2760

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     2820

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     2880

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     2940

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     3000

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     3060

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     3120

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     3180

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     3240

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     3300

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     3360

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     3420

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     3480

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     3540

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     3600

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     3660

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     3720

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     3780

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     3840

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     3900

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     3960

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     4020

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     4080

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     4140

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     4200

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     4260

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     4320

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     4380

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     4440

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     4500

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     4560

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt     4620

ccaaaaaaga agagaaaggt agccctcgag tacccatatg atgtccctga ctacgct        4677


<210>  870
<211>  4764
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-P1/P6-P1/P6-X plasmid sequence

<400>  870
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

tttttaggga agatctggcc ttcccacaag ggaaggccag ggaattttct tcagagcaga     1560

ccagagccaa cagccccacc agaagagagc ttcaggtttg gggaagagac aacaactccc     1620

tctcagaagc aggagccgat agacaaggaa ctgtatcctt tagcttccct cagatcactc     1680

tttggcagcg acccctcgtc acaaaacttt agccagaact atccgattgt gcagaccggt     1740

gccccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa caagatcaga     1800

aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc catgaaaacc     1860

ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct gagaaagaag     1920

cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa caagctgctg     1980

accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga gttccagaaa     2040

gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat cgaccagaac     2100

aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt tgcctgctct     2160

cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa aggcaaggcc     2220

tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat tctgctggcc     2280

cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg caagtttgga     2340

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag     2400

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc     2460

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag     2520

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc     2580

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc     2640

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg     2700

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     2760

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     2820

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     2880

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     2940

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     3000

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     3060

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     3120

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     3180

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     3240

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     3300

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     3360

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     3420

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     3480

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     3540

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     3600

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     3660

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     3720

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     3780

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     3840

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     3900

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     3960

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     4020

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     4080

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     4140

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     4200

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     4260

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     4320

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     4380

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     4440

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     4500

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     4560

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     4620

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     4680

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc cctcgagtac     4740

ccatatgatg tccctgacta cgct                                            4764


<210>  871
<211>  4398
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-X-P1/P6 plasmid sequence

<400>  871
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcatgcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaccggtg ccccaaagaa gaagcggaag gtctctagac aagagatcaa gagaatcaac     1200

aagatcagaa ggagactggt caaggacagc aacacaaaga aggccggcaa gacaggcccc     1260

atgaaaaccc tgctcgtcag agtgatgacc cctgacctga gagagcggct ggaaaacctg     1320

agaaagaagc ccgagaacat ccctcagcct atcagcaaca ccagcagggc caacctgaac     1380

aagctgctga ccgactacac cgagatgaag aaagccatcc tgcacgtgta ctgggaagag     1440

ttccagaaag accccgtggg cctgatgagc agagttgctc agcctgccag caagaagatc     1500

gaccagaaca agctgaagcc cgagatggac gagaagggca atctgaccac agccggcttt     1560

gcctgctctc agtgtggcca gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa     1620

ggcaaggcct acaccaacta cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt     1680

ctgctggccc agctgaaacc tgagaaggac tctgatgagg ccgtgaccta cagcctgggc     1740

aagtttggac agagagccct ggacttctac agcatccacg tgaccaaaga aagcacacac     1800

cccgtgaagc ccctggctca gatcgccggc aatagatacg cctctggacc tgtgggcaaa     1860

gccctgtccg atgcctgcat gggaacaatc gccagcttcc tgagcaagta ccaggacatc     1920

atcatcgagc accagaaggt ggtcaagggc aaccagaaga gactggaaag cctgagggag     1980

ctggccggca aagagaacct ggaatacccc agcgtgaccc tgcctcctca gcctcacaca     2040

aaagaaggcg tggacgccta caacgaagtg atcgccagag tgagaatgtg ggtcaacctg     2100

aacctgtggc agaagctgaa actgtccagg gacgacgcca agcctctgct gagactgaag     2160

ggcttcccta gcttccctct ggtggaaaga caggccaatg aagtggattg gtgggacatg     2220

gtctgcaacg tgaagaagct gatcaacgag aagaaagagg atggcaaggt tttctggcag     2280

aacctggccg gctacaagag acaagaagcc ctgaggcctt acctgagcag cgaagaggac     2340

cggaagaagg gcaagaagtt cgccagatac cagctgggcg acctgctgct gcacctggaa     2400

aagaagcacg gcgaggactg gggcaaagtg tacgatgagg cctgggagag aatcgacaag     2460

aaggtggaag gcctgagcaa gcacattaag ctggaagagg aaagaaggag cgaggacgcc     2520

caatctaaag ccgctctgac cgattggctg agagccaagg ccagctttgt gatcgagggc     2580

ctgaaagagg ccgacaagga cgagttctgc agatgcgagc tgaagctgca gaagtggtac     2640

ggcgatctga gaggcaagcc cttcgccatt gaggccgaga acagcatcct ggacatcagc     2700

ggcttcagca agcagtacaa ctgcgccttc atttggcaga aagacggcgt caagaaactg     2760

aacctgtacc tgatcatcaa ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa     2820

cccgaggcct tcgaggctaa cagattctac accgtgatca acaaaaagtc cggcgagatc     2880

gtgcccatgg aagtgaactt caacttcgac gaccccaacc tgattatcct gcctctggcc     2940

ttcggcaaga gacagggcag agagttcatc tggaacgatc tgctgagcct ggaaaccggc     3000

tctctgaagc tggccaatgg cagagtgatc gagaaaaccc tgtacaacag gagaaccaga     3060

caggacgagc ctgctctgtt tgtggccctg accttcgaga gaagagaggt gctggacagc     3120

agcaacatca agcccatgaa cctgatcggc gtggaccggg gcgagaatat ccctgctgtg     3180

atcgccctga cagaccctga aggatgccca ctgagcagat tcaaggactc cctgggcaac     3240

cctacacaca tcctgagaat cggcgagagc tacaaagaga agcagaggac aatccaggcc     3300

aagaaagagg tggaacagag aagagccggc ggatactcta ggaagtacgc cagcaaggcc     3360

aagaatctgg ccgacgacat ggtccgaaac accgccagag atctgctgta ctacgccgtg     3420

acacaggacg ccatgctgat cttcgagaat ctgagcagag gcttcggccg gcagggcaag     3480

agaaccttta tggccgagag gcagtacacc agaatggaag attggctcac agctaaactg     3540

gcctacgagg gactgagcaa gacctacctg tccaaaacac tggcccagta tacctccaag     3600

acctgcagca attgcggctt caccatcacc agcgccgact acgacagagt gctggaaaag     3660

ctcaagaaaa ccgccaccgg ctggatgacc accatcaacg gcaaagagct gaaggttgag     3720

ggccagatca cctactacaa caggtacaag aggcagaacg tcgtgaagga tctgagcgtg     3780

gaactggaca gactgagcga agagagcgtg aacaacgaca tcagcagctg gacaaagggc     3840

agatcaggcg aggctctgag cctgctgaag aagaggttta gccacagacc tgtgcaagag     3900

aagttcgtgt gcctgaactg cggcttcgag acacacgccg atgaacaggc tgccctgaac     3960

attgccagaa gctggctgtt cctgagaagc caagagtaca agaagtacca gaccaacaag     4020

accaccggca acaccgacaa gagggccttt gtggaaacct ggcagagctt ctacagaaaa     4080

aagctgaaag aagtctggaa gcccgccgtg actagtccaa aaaagaagag aaaggtagcc     4140

ctcgagtacc catatgatgt ccctgactac gctggcggtg gaagacaggc taatttttta     4200

gggaagatct ggccttccca caagggaagg ccagggaatt ttcttcagag cagaccagag     4260

ccaacagccc caccagaaga gagcttcagg tttggggaag agacaacaac tccctctcag     4320

aagcaggagc cgatagacaa ggaactgtat cctttagctt ccctcagatc actctttggc     4380

agcgacccct cgtcacaa                                                   4398


<210>  872
<211>  4275
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-NC-X-P1/P6 plasmid sequence

<400>  872
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagac cggtgcccca     1320

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1380

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1440

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1500

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1560

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1620

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1680

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1740

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1800

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     1860

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     1920

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     1980

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2040

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2100

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2160

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2220

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2280

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2340

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2400

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2460

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2520

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2580

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2640

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2700

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2760

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     2820

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     2880

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     2940

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3000

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3060

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3120

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3180

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3240

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3300

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3360

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3420

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3480

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3540

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3600

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3660

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3720

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3780

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     3840

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     3900

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     3960

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4020

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4080

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4140

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4200

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4260

tggaagcccg ccgtg                                                      4275


<210>  873
<211>  4560
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  MA-CA-P2-P1/P6-X plasmid sequence

<400>  873
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

aactttagcc agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc     1560

tctagacaag agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac     1620

acaaagaagg ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct     1680

gacctgagag agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc     1740

agcaacacca gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa     1800

gccatcctgc acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga     1860

gttgctcagc ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag     1920

aagggcaatc tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg     1980

tacaagctgg aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt     2040

aacgtggccg agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct     2100

gatgaggccg tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc     2160

atccacgtga ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat     2220

agatacgcct ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc     2280

agcttcctga gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac     2340

cagaagagac tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc     2400

gtgaccctgc ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc     2460

gccagagtga gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac     2520

gacgccaagc ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag     2580

gccaatgaag tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag     2640

aaagaggatg gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg     2700

aggccttacc tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag     2760

ctgggcgacc tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac     2820

gatgaggcct gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg     2880

gaagaggaaa gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga     2940

gccaaggcca gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga     3000

tgcgagctga agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag     3060

gccgagaaca gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt     3120

tggcagaaag acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc     3180

ggcaagctgc ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc     3240

gtgatcaaca aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac     3300

cccaacctga ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg     3360

aacgatctgc tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag     3420

aaaaccctgt acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc     3480

ttcgagagaa gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg     3540

gaccggggcg agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg     3600

agcagattca aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac     3660

aaagagaagc agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga     3720

tactctagga agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc     3780

gccagagatc tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg     3840

agcagaggct tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga     3900

atggaagatt ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc     3960

aaaacactgg cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc     4020

gccgactacg acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc     4080

atcaacggca aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg     4140

cagaacgtcg tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac     4200

aacgacatca gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag     4260

aggtttagcc acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca     4320

cacgccgatg aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa     4380

gagtacaaga agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg     4440

gaaacctggc agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact     4500

agtccaaaaa agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct     4560


<210>  874
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  874

Ser Ala Val His Ser Val Arg Leu 
1               5               


<210>  875
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  875

Arg Thr Val Asn Thr Val Arg Val 
1               5               


<210>  876
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  876

Asn Thr Val His Thr Val Arg Gln Val Glu Ser 
1               5                   10      


<210>  877
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  877

Ala Ala Val His Thr Val Lys Ala 
1               5               


<210>  878
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  878

Arg Thr Val Asn Thr Val Thr Thr 
1               5               


<210>  879
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  879

Arg Ser Val Asn Thr Val Thr Ala 
1               5               


<210>  880
<211>  2413
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pStx42.174.12.7 plasmid sequence

<400>  880
gctagctagg tctagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt       60

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa      120

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt      180

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa      240

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac      300

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt      360

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt      420

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat      480

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac      540

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg      600

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc      660

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa      720

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag      780

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct      840

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat      900

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa      960

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     1020

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     1080

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     1140

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     1200

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     1260

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     1320

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     1380

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     1440

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     1500

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     1560

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     1620

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     1680

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     1740

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     1800

ccgacaggcc cgaaggaata gaagaagaag gtggagagag agacagagac agatccattc     1860

gattagtgaa cggatctcga cggtatcgcc tttaaaagaa aaggggggat tggggggtac     1920

agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa agaactacaa     1980

aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag agatccagtt     2040

tgagggccta tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga     2100

gataattgga attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag     2160

aaagtaataa tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca     2220

tatgcttacc gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg     2280

acgaaacacc actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc     2340

gtagtgggta aagctccctc ttcggaggga gcatcaaagc tgcattctag ttgtggtttt     2400

tttttttgaa ttc                                                        2413


<210>  881
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 plasmid sequence

<400>  881
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  882
<211>  5178
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP40 plasmid sequence

<400>  882
atggaagccg tgatcaaggt gatcagctcc gcatgcaaga cctactgtgg caagacgagc       60

ccaagcaaga aggaaatcgg cgctatgctg agcctgctgc agaaggaggg cctcctgatg      120

agcctgtctg atctgtacag cccaggtagc tgggacccta tcaccgccgc cctgacacag      180

agagccatgg tgctgggcaa aagcggcgag ctgaagacat ggggactggt gctgggcgcc      240

ctgaaagccg ctagagaaga gcaagtaacc agcgagcagg ccaagttctg gctgggactg      300

ggcggcggta gagtgagccc ccctggccct gagtgcatcg agaagcctgc caccgagcgg      360

cgcattgaca aaggcgaaga agtgggcgag acaaccgtgc agagagacgc caagatggct      420

ccagaagaga cagcaacccc aaagaccgtg ggcaccagct gctaccactg cggcaccgct      480

atcggctgca actgcgccac cgccagcgcg cctcctcccc cgtatgtggg cagcggcctc      540

tacccctccc tggcaggagt gggagagcag cagggccagg gcggagatac acccagaggc      600

gccgagcagc ctagagccga acccggccac gccggccagg cccctggccc cgccctgacc      660

gactgggcca gaatcagaga ggagctggcc tctacaggcc ctccagtggt cgccatgcct      720

gtggtgatca agaccgaggg acctgcctgg acccctctgg aacctaaact gattacacgg      780

ctggctgata ccgtcagaac caagggcctc agaagcccca tcacaatggc cgaagtggaa      840

gccctgatga gcagcccact gctgcctcac gacgtgacca acctgatgcg ggtgatcctg      900

ggccccgccc cttacgccct gtggatggac gcctggggcg tgcagctgca aacagttatc      960

gccgccgcca caagagaccc ccggcaccca gccaacggcc agggcagagg cgagagaaca     1020

aacctggatc ggctgaaggg cctcgccgat ggcatggccg gcaatcctga gggccaggct     1080

gctctgctga gacccgggga actggttgct atcaccgcca gcgccctgca ggccttcaga     1140

gaagtggccc ggctggccga gcctacagac ccctgggccg agatcaccca gggcccttct     1200

gagagcttcg tggacttcgc caacagactg atcaaggccg ttgagggctc cgacctgcct     1260

cctagcgccc gcgcccccgt gatcatcgac tgttttagac agaaatcgca acccgacatc     1320

cagcagctga tccgggccgc tccttctacc ctgaccacac ctggcgagat catcaagtac     1380

gtgctggaca gacagaagac cgcccccctg accgacagag gaatcgccgc cgccatgtct     1440

agcgccattc agcctctggt gatggccgtg gtcaacagag aaagagatgg acagacaggt     1500

tctggcggca gagcccgggg cctgtgctac acctgcggat cccctggaca ctaccaggcc     1560

cagtgtccta agaaaagaaa gtctggtaac agcagagagc ggtgccagct gtgtgatggc     1620

atgggccaca acgccaaaca gtgccggaga cgggacggaa accaaggaca aagacccggc     1680

cggggactga gcagcggacc ttggcctgtc agccagcaac ctgccgtgtc cctggctatg     1740

accatggaac acaaggaccg gcctctggtg cgggtgatcc tgacaaatac cggctctcac     1800

cccgtgaagc agcggtcagt gtacatcaca gccctgctgg acagcggcgc tgatatcacc     1860

atcattagcg aggaggactg gcctaccgac tggcccgtga tggaagctgc caatccccag     1920

atccacggca tcggaggcgg aatcccgatg agaaagtcca gagacatgat cgaggtgggc     1980

gtgatcaacc gggacggctc tcttgagaga cctctgctgc tgttccccgc cgtggctatg     2040

gtgcgaggca gcatcctggg ccgcgactgc ctgcagggcc tgggcctgag actgaccaac     2100

ctgaacttta gccagggtgc caccagctgc taccactgcg gcaccggcgg cagcccaaag     2160

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     2220

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     2280

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     2340

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     2400

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     2460

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     2520

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     2580

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     2640

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     2700

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     2760

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2820

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2880

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2940

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     3000

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     3060

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     3120

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     3180

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     3240

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     3300

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     3360

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     3420

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     3480

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     3540

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     3600

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     3660

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     3720

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3780

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3840

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3900

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3960

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     4020

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     4080

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     4140

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     4200

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     4260

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     4320

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     4380

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     4440

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     4500

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     4560

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     4620

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     4680

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     4740

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4800

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4860

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4920

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4980

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     5040

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     5100

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     5160

gtccctgact acgcttga                                                   5178


<210>  883
<211>  5187
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP41 plasmid sequence

<400>  883
atggaggccg tgatcaaggt gatcagcagc gcatgcaaga cctactgcgg caagaccagc       60

ccatctaaga aagagatcgg cgccatgctg agcctgctcc aaaaggaagg cctgctgatg      120

agcccttccg acctgtacag ccccggaagc tgggacccaa tcaccgctgc cctgacccag      180

cgggccatgg tgctgggaaa gagcggcgag ctgaagacct ggggcctggt gctgggagcc      240

ctgaaggccg ccagagagga acaagtgaca agcgaacagg ccaagttctg gctgggactg      300

ggcggaggaa gagtcagccc tcctggccca gagtgcatcg agaagcccgc tacagagaga      360

agaatcgata agggcgaaga ggtgggcgag acaacagtgc agagagacgc caagatggct      420

cctgaggaaa ccgccacacc taagaccgtg ggcacatctt gttaccactg cggcaccgcc      480

attggatgta actgcgctac agccagcgcc cccccccctc cctacgtggg cagcggactt      540

tatcctagcc tggccggcgt gggagagcag cagggccaag gcggagatac acccagaggc      600

gccgagcagc ctagagccga acccggccac gccggactgg cccctggccc agccctgacc      660

gactgggccc gcatccggga agaactggct tctaccggcc ccccggtggt cgccatgcct      720

gtggttatca agacagaggg ccctgcttgg acccctctgg aaccaaagct gattacaaga      780

ctcgccgaca ccgtgcggac caagggcctg cggagcccta tcaccatggc cgagatggaa      840

gctctgatga gcagcccact gctgccccac gacgtgacca acctgatgag agtgatcctg      900

ggccccgccc cttacgccct gtggatggac gcctgggggg tgcagctgca gaccgtgatt      960

gccgccgcca ccagagatcc tagacaccct gctaacggcc aaggcagagg cgaaagaacc     1020

aaccttgaca gactgaaagg cctggccgat ggaatggtcg gcaacagcga aggccaggcc     1080

gccctgctga gacctggcga gctggtggct atcacagcca gcgccctgca ggccttcaga     1140

gaagtggccc gactggctga gcccacggac ccttgggccg acatcatgca gggcccttct     1200

gagagcttcg tggacttcgc caatagactg atcaaggccg tcgagggcag cgatcttcct     1260

cctagcgcga gagcccctgt tatcatcgac tgcttccggc agaaaagcca gcccgacatc     1320

caacagctga tcagagccgc cccttccacc ctgaccacac caggcgagat catcaagtac     1380

gtgctggata gacagaagac cgcccctctg accgatcagg gcatcgccgc tgccatgtcc     1440

tctgccatcc agcctctggt gatggccgtg gtgaacagag agagagacgg ccagacaggc     1500

tccggcggcc gggccagaga gctgtgctac acctgtggct ctccaggcca ctaccaggct     1560

cagtgtccta aaaagcggaa gtctggcaat tctagagagc ggtgccagct gtgcaacggc     1620

atgggccata atgccaaaca gtgtcggaaa cgggacggaa accagggcca gagaccaggc     1680

agaggcctgt cttctggccc ctggcccggc cctgagcctc ctgctgtgtc cctggctatg     1740

accatggaac acaaggacag acccctggtg cgggtgatcc tgacaaacac cggaagccac     1800

cccgtgaagc agcgctccgt gtacatcaca gcccttctgg acagcggcgc cgacatcacc     1860

atcatcagcg aggaagattg gcctacagac tggcctgtga tggaagccgc aaacccccag     1920

atccacggca tcggcggagg tatacccatg cggaagagca gagacatgat cgagctgggc     1980

gtgatcaacc gggacggcag cctggaacgg cccctgctgt tgtttcctgc tgtggctatg     2040

gtgcggggaa gcatcctggg cagagattgc ctgcagggcc tgggcctgcg cctgaccaac     2100

ctgtgaggag ggccactgtt ctcaggtgcc acatcttgtt accactgcgg caccggcggc     2160

agcccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa caagatcaga     2220

aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc catgaaaacc     2280

ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct gagaaagaag     2340

cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa caagctgctg     2400

accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga gttccagaaa     2460

gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat cgaccagaac     2520

aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt tgcctgctct     2580

cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa aggcaaggcc     2640

tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat tctgctggcc     2700

cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg caagtttgga     2760

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag     2820

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc     2880

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag     2940

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc     3000

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc     3060

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg     3120

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     3180

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     3240

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     3300

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     3360

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     3420

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     3480

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     3540

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     3600

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     3660

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     3720

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     3780

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     3840

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     3900

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     3960

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     4020

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     4080

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     4140

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     4200

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     4260

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     4320

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     4380

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     4440

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     4500

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     4560

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     4620

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     4680

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     4740

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     4800

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     4860

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     4920

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     4980

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     5040

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     5100

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc cctcgagtac     5160

ccatatgatg tccctgacta cgcttga                                         5187


<210>  884
<211>  5684
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP42 plasmid sequence

<400>  884
atgggccaga cccacagcag acaactgttc gtgcacatgc tgtccgtgat gctgaagcac       60

agaggcatca ccgtgtctaa gcctaagctg atcaacttcc tgagcttcat cgaggaagtg      120

tgtccttggt ttccacggga aggcacagtg aacctggaaa catggaaaaa ggtgggcgaa      180

cagatcagaa cccactacac cctgcacggc cctgagaagg tgcctgtgga aacactttcc      240

ttctggaccc tgatccgcga ctgcctggat ttcgacaatg acgagctgaa aagactgggc      300

aacctgctca agcaggagga agatcctctg cacgaccctg acagcgagaa cagctacgac      360

gcccctcctc ctcctcatcc tagcctgcac tctagcagac cttccgacaa cgacgacctg      420

ctgtctagca cagacgaggc cgagctggac gaggaagccg ccaagtacca ccaggaggac      480

tggggcttcc tggctcagga gaaaggcgcc ctgacaagca aggacgagct ggtggaatgt      540

ttcaagaacc tgaccatcgc cctgcagaac gctggaatca agctgccagc caacaacgat      600

aagttcccct ccgccccccc tctgcctcct gcctacgccc ctagcgtggt ggccggactg      660

gatccacccc ccggccccct gcccccaagc aagaacatgt ctccactgca gaaagccctg      720

agacaagccc agaggctggg cgaagttgtg tccgatttca gcctggcctt ccccgtgttc      780

gagaacaaca accagcggta ctacgagagc ctgcctttca agcagctgaa ggaactcaaa      840

atcgcatgca gccagtacgg ccctaccgca ccttttacca tcgccatgat cgagaacctc      900

ggcacccagg ccctgccacc taatgattgg aagcagacag ccagagcctg cctgtcaggc      960

ggagattacc tgctgtggaa gagcgagttc ttcgagcaat gcgccagaat cgctgacgtg     1020

aaccggcagc agggcatcca gacgagctac gagatgctga tcggcgaggg accctaccag     1080

gccaccgaca cccagctgaa cttcctgcct ggggcctatg cccaaatcag caacgccgcc     1140

agacaggctt ggaagaaact gcctagctct tctacaaaga ccgaggacct gagcaaagtg     1200

cggcaaggcc ccgatgagcc ctaccaggac tttgtcgcca gactgctcga caccatcggc     1260

aagatcatga gcgacgaaaa ggccggcatg gtcctggcta agcaactggc tttcgagaat     1320

gctaatagcg cctgtcaggc cgccctgcgg ccttacagaa agaagggcga cctgtccgat     1380

tttatcagaa tctgcgccga catcggcccc tcttatatgc agggaattgc catggccgct     1440

gctctgcagg gcaaaagcat caaggaagtg cttttccagc agcaagctcg gaacaagcgg     1500

ggaagacaga gaagcggcaa tagcggttgt tttgtgtgcg gccagcccgg ccaccgcgcc     1560

gccgtgtgcc cccagaagca gcagagcccc gtgaacaccc ctaatctgtg cccgcgctgt     1620

aaaaaaggaa agcattgggc acgagattgc cggtccaaaa cagatgttca aggtacccct     1680

ttacccccgg tgtcgggaaa ctgggtgagg ggccagcccc tggccccgaa acaatgttat     1740

ggggcaacac tgcaggttcc aaaagaacca ttgcagacct ctgtcgagcc acaagaggca     1800

gcgcgggatt ggacctctgt gccacctcct acacagtatt aactcccgag atgggggtcc     1860

aaaccctggc tacaggcgtg ttcggtcctc tgccccccgg caccgccggc ctgctgctgg     1920

gcagaagcag cgccagcctg aagggcatcc tgatccatcc tggagtgatt gacagcgact     1980

acaccggcga gatcaagatc ctggcctctg cccctaacaa gatcatcgtg atcaacgccg     2040

gccaaagaat cgcccagctg ctgctcgtgc ctctggtgat ccagggcaaa accatcaacc     2100

gggacaggca ggacaaggga tttggatctt ctgacgccta ttgggtgcag aacgtgaccg     2160

aggccagacc tgaactggaa cttagaatca atggcaagct gttccggggc gtgctggata     2220

caggcgccga catcagcgtg atcagcgaca aatactggcc caccacctgg cctaagcaga     2280

tggctatctc tacactgcag ggcatcggcc agacaaccaa ccccgagcag agcagcagcc     2340

tgctgacctg gaaggacaag gacggccaca ccggccaatt caagccctac atcctgcctc     2400

acctgcctgt gaacctgtgg ggcagagata tcctgagcaa gatgggcgtc tacctgtact     2460

cccctagccc taccgtgaca gatctgatgc tggaccaggg cctgctgcct aatcagggcc     2520

tcggaaagca acaccaggga attatcctgc cactggacct gaaaagcaac caggatagaa     2580

agggcctggg atgcttcccc tgaggacctc tgattctcct gggtgccgac tgcctggatt     2640

tcgacaatga cggcggcagc ccaaagaaga agcggaaggt ctctagacaa gagatcaaga     2700

gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag gccggcaaga     2760

caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga gagcggctgg     2820

aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc agcagggcca     2880

acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg cacgtgtact     2940

gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag cctgccagca     3000

agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat ctgaccacag     3060

ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg gaacaggtgt     3120

ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc gagcacgaga     3180

agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc gtgacctaca     3240

gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg accaaagaaa     3300

gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc tctggacctg     3360

tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg agcaagtacc     3420

aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga ctggaaagcc     3480

tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg cctcctcagc     3540

ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg agaatgtggg     3600

tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag cctctgctga     3660

gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa gtggattggt     3720

gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat ggcaaggttt     3780

tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac ctgagcagcg     3840

aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac ctgctgctgc     3900

acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc tgggagagaa     3960

tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa agaaggagcg     4020

aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc agctttgtga     4080

tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg aagctgcaga     4140

agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac agcatcctgg     4200

acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa gacggcgtca     4260

agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg cggttcaaga     4320

agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac aaaaagtccg     4380

gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg attatcctgc     4440

ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg ctgagcctgg     4500

aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg tacaacagga     4560

gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga agagaggtgc     4620

tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc gagaatatcc     4680

ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc aaggactccc     4740

tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag cagaggacaa     4800

tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg aagtacgcca     4860

gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat ctgctgtact     4920

acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc ttcggccggc     4980

agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat tggctcacag     5040

ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg gcccagtata     5100

cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac gacagagtgc     5160

tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc aaagagctga     5220

aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc gtgaaggatc     5280

tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc agcagctgga     5340

caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc cacagacctg     5400

tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat gaacaggctg     5460

ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag aagtaccaga     5520

ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg cagagcttct     5580

acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa aagaagagaa     5640

aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga                      5684


<210>  885
<211>  5637
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP43 plasmid sequence

<400>  885
atgggcgtgt ccggctcaaa gggccagaag ctgtttgtgt ccgtgctgca gcgtctgctg       60

tccgaacggg gcctacacgt gaaagagagc agcgccatcg agttctacca gtttctgatc      120

aaggtgtcac cctggttccc cgaggaaggc ggcctgaatc tgcaggattg gaagagagtg      180

ggcagagaaa tgaagaagta cgccgctgag cacggcaccg acagcatccc caagcaggct      240

tatcctatct ggctgcaact gagagagatc ctgacagagc aatctgacct ggtgctgctg      300

agcgccgagg ccaagtccgt gacagaggaa gaactggaag aaggcctgac aggactgctg      360

agcgccagca gccaggagaa gacctacggc acaagaggca ccgcctatgc cgaaatcgac      420

accgaggtgg ataagctgag cgagcacatc tacgacgagc cctacgagga gaaggaaaag      480

gccgacaaga acgaggagaa ggaccacgtg cggaaggtca agaagatcgt gcaaagaaag      540

gaaaatagcg agcataagag aaaggagaaa gatcagaagg ccttcctggc aaccgactgg      600

aacaacgacg acctgagccc tgaggactgg gacgacctgg aagagcaggc cgcccactac      660

cacgatgacg acgaactgat cctgcctgtg aagagaaagg tggacaagaa gaagccgctc      720

gccctgaggc ggaaacctct gcccccggtt ggcttcgccg gagccatggc cgaggctaga      780

gagaagggcg atctgacctt cacatttccc gtggttttca tgggagaatc cgacgacgat      840

gatacccctg tgtgggaacc tctgcccctg aagacactga aggaactgca gtctgccgtg      900

cggaccatgg gccctagcgc cccttacacc ctccaggtgg tggacatggt tgcctctcag      960

tggctgacac ctagcgattg gcaccaaacc gccagagcca ccctgtctcc tggggactac     1020

gtgctgtggc ggaccgagta cgaggagaag agcaaggaaa ccgtgcagaa gaccgctggc     1080

aagcggaaag gcaaggtgag cctggatatg ctgctgggca caggtcagtt cctgagccct     1140

tcttctcaga tcaagctttc taaagatgtg ctgaaggatg tgaccaccaa cgccgtcctg     1200

gcctggagag ccatccctcc tccaggcgtc aaaaagacag tgctggccgg actcaagcag     1260

ggaaatgagg aaagctacga gacattcatc agcagactgg aagaggccgt gtacagaatg     1320

atgcctagag gagaaggcag cgacatcctg atcaagcagc tggcttggga gaacgctaat     1380

tctctgtgcc aggacctgat ccggcctatg cggaagaccg gcaccatgca ggactacatc     1440

agagcctgtc tggatgcctc ccctgccgtg gtgcagggca tggcctacgc cgccgcaatg     1500

agaggacaaa agtacagcac cttcgtgaaa cagacatacg gcggcggaaa aggcggacag     1560

ggctctgaag gccctgtgtg cttcagctgc ggcaaaacag gtcacattaa gcgggattgc     1620

aaggaagaga aaggaagcaa gcgcgctcct cctggactgt gtcctagatg caagaaaggc     1680

taccactgga agagcgagtg caagagcaag ttcgacaagg acggcaaccc tctgccacca     1740

ctggaaacta acgccgaaaa cagcaaaaac cccacacaga aaggcgacaa aggaaaggac     1800

agcggactga accccgaagc ccctcctttc accatccacg acctgccacg aggcacccca     1860

ggcagtgccg gcttggacct gagcagccag aaagacctga tcctgtctct ggaagacggc     1920

gtgtccctgg tgccaaccct ggtgaagggc accctgcccg agggcaccac gggactgatc     1980

atcggcagat ccagcaacta caagaaaggc ctggaggtgc tgcccggcgt gatcgactcc     2040

gacttccagg gcgaaattaa ggtcatggta aaggccgcta agaacgccgt gatcatccac     2100

aagggcgagc ggatcgcgca gctgctgctg ctgccttatc tgaaactgcc taaccctatc     2160

atcaaggagg aaagaggcag cgagggattt ggcagcacct cccacgtgca ctgggtgcag     2220

gagatcagcg acagcagacc catgctgcac atcagcctga acggcagaag attcctgggc     2280

ctgctggaca ccggggccga taagacctgc atcgccggca gagattggcc cgccaactgg     2340

cctattcacc agaccgagag cagcctgcag ggcttgggaa tggcttgtgg cgtggctaga     2400

agctctcagc ctctgagatg gcagcacgag gataagtctg gcattatcca tcctttcgtg     2460

atccccacat tgccttttac cctctggggc cgggacatca tgaaagagat aaaggtgcgg     2520

ctgatgaccg atagcccaga cgacagccag gatctgacat ctctgtacgg cttaggtgcc     2580

gacctggtgc tgctgagcgc cgagggcggc agcccaaaga agaagcggaa ggtctctaga     2640

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     2700

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     2760

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     2820

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     2880

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     2940

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     3000

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     3060

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     3120

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     3180

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     3240

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     3300

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     3360

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     3420

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     3480

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     3540

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     3600

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     3660

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     3720

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     3780

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     3840

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     3900

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     3960

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     4020

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     4080

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     4140

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     4200

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     4260

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     4320

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     4380

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     4440

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     4500

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     4560

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     4620

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     4680

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     4740

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     4800

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     4860

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     4920

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     4980

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     5040

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     5100

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     5160

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     5220

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     5280

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     5340

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     5400

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     5460

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     5520

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     5580

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        5637


<210>  886
<211>  5811
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP44 plasmid sequence

<400>  886
atgggccagg agctgtccca gcacgagcgg tacgtggagc agctgaagca agcccttaaa       60

acaagaggcg tgaaggtgaa atacgccgac ctgctgaagt tcttcgattt tgtgaaggat      120

acctgccctt ggttccctca ggagggcacc atcgacatca agagatggcg cagagtgggc      180

gactgcttcc aagattacta caacaccttc ggacctgaga aagtgcctgt gaccgccttc      240

agctactgga acctgatcaa ggaactgatc gacaaaaagg aagtgaaccc acaggtgatg      300

gctgctgtcg cccagaccga ggaaatcctg aagagcaaca gccagacaga cctgaccaag      360

accagccaga accctgacct ggatctgatc agcctggaca gcgatgatga gggcgccaag      420

tccagcagcc tgcaggacaa gggcctgagc agcaccaaaa agcctaagcg gttccccgtc      480

ctgctgaccg cccagacaag caaggaccca gaggatccta acccaagcga ggtggactgg      540

gacggcctgg aggacgaggc cgctaagtac cacaaccctg actggccccc cttcctgaca      600

agacctccac cttacaacaa ggctacccct agcgccccta ccgtgatggc cgtggtgaac      660

cctaaagagg aactgaaaga aaagatcgcc cagctggaag agcagatcaa actggaagag      720

ctgcaccagg ccctgatttc taagctgcaa aagctgaaaa ccggcaacga gacagtcact      780

caccctgata cagccggagg cctgagcaga acaccacatt ggcccggcca gcacatccct      840

aagggcaagt gctgcgccag ccgggaaaag gaagagcaga tccccaagga tatcttccct      900

gtgaccgaaa ccgttgacgg acagggccag gcatggagac accacaatgg cttcgacttc      960

gccgtgatca aggaactgaa gacagccgcc tctcaatacg gcgccaccgc accttacacc     1020

ctggctatcg tggaatccgt cgccgacaac tggctgaccc caaccgactg gaataccctg     1080

gtgcgggccg tgctgtctgg cggcgaccac ctgctctgga agtctgagtt cttcgagaac     1140

tgtagggaca ccgctaagcg gaaccagcag gccggcaatg gatgggattt tgacatgctg     1200

accggcagcg gcaactacag ctctacagac gcccaaatgc agtacgaccc tggcctgttc     1260

gcccagattc aggccgctgc cacaaaggcc tggcggaagc tgcccgtgaa gggggatccc     1320

ggcgccagcc tgaccggcgt gaagcagggc cccgatgagc ctttcgccga cttcgtgcat     1380

agactgatca ccacagccgg cagaatcttc ggctccgccg aagccggcgt ggactacgtg     1440

aagcagctgg cttacgagaa cgccaaccct gcctgccagg ccgcaatcag accctataga     1500

aagaagacag atctgaccgg ctacatccgg ctgtgcagcg acatcggccc ttcctatcag     1560

cagggactgg ctatggccgc tgcctttagc ggccagaccg tgaaggactt cctgaacaac     1620

aagaacaagg aaaagggcgg atgttgtttt aagtgcggca agaaaggaca ctttgccaaa     1680

aactgccacg agcacgccca caacaacgcc gagcccaagg tgcccggcct gtgtcctcgg     1740

tgcaagagag gcaagcactg ggccaatgag tgcaagtcca agacagataa ccagggaaat     1800

ccaatccccc cccatcaggg aaatggtgct tctcctagac ctagaaacaa gctgatgggc     1860

caaagcgccc tgttccagcc taccaagaca acccacttca aggcctacca gagccacccc     1920

agaaagtgca gaatcggccc tctgttccac ctgccccaca gcatcaacgc ctgaaatggg     1980

gccccaagcg ttaagcactg gaatatatgg accactgcct cccaacactt ttggattaat     2040

cctaggccga agtagcatta ctatgaaggg tctacaagtt tatccaggag taattgataa     2100

tgactatacc ggagaaatta aaattatggc aaaagctgtt aacaatattg ttactgtctc     2160

tcaaggcaac agaatagctc aattaatcct cctgcctctg atcgagacag acaataaggt     2220

acaacaacct tatagaggac aaggaagttt tggatcctca gacatatatt gggtccagcc     2280

tatcacctgt cagaagcctt ctctgaccct gtggctggac gacaagatgt tcaccggcct     2340

catcgacacc ggcgccgacg tgacaatcat caagctggaa gattggcctc caaattggcc     2400

cattacagat accctgacca acctgagagg catcggacag tccaacaacc ccaagcagag     2460

cagcaagtac ctgacatggc gggacaagga gaacaacagc ggcctgatca aaccttttgt     2520

gatccccaat ctgcctgtga acctgtgggg aagagatctg ctgtctcaga tgaagatcat     2580

gatgtgcagc ccaaacgaca tcgtgaccgc ccagatgctg gctcaaggct acagccccgg     2640

caaaggcctg ggcaagaaag agaatggaat cctgcaccct atccctaacc agggccagag     2700

caacaagaag ggcttcggca acttctgact gcggccattg acatacttgg tgccccacag     2760

gtgatggctg ctgtcgccgg cggcagccca aagaagaagc ggaaggtctc tagacaagag     2820

atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac aaagaaggcc     2880

ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga cctgagagag     2940

cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag caacaccagc     3000

agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc catcctgcac     3060

gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt tgctcagcct     3120

gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa gggcaatctg     3180

accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta caagctggaa     3240

caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa cgtggccgag     3300

cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga tgaggccgtg     3360

acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat ccacgtgacc     3420

aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag atacgcctct     3480

ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag cttcctgagc     3540

aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca gaagagactg     3600

gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt gaccctgcct     3660

cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc cagagtgaga     3720

atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga cgccaagcct     3780

ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc caatgaagtg     3840

gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa agaggatggc     3900

aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag gccttacctg     3960

agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct gggcgacctg     4020

ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga tgaggcctgg     4080

gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga agaggaaaga     4140

aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc caaggccagc     4200

tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg cgagctgaag     4260

ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc cgagaacagc     4320

atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg gcagaaagac     4380

ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg caagctgcgg     4440

ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt gatcaacaaa     4500

aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc caacctgatt     4560

atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa cgatctgctg     4620

agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa aaccctgtac     4680

aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt cgagagaaga     4740

gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga ccggggcgag     4800

aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag cagattcaag     4860

gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa agagaagcag     4920

aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata ctctaggaag     4980

tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc cagagatctg     5040

ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag cagaggcttc     5100

ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat ggaagattgg     5160

ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa aacactggcc     5220

cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc cgactacgac     5280

agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat caacggcaaa     5340

gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca gaacgtcgtg     5400

aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa cgacatcagc     5460

agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag gtttagccac     5520

agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca cgccgatgaa     5580

caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga gtacaagaag     5640

taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga aacctggcag     5700

agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag tccaaaaaag     5760

aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg a              5811


<210>  887
<211>  4779
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP45 plasmid sequence

<400>  887
atgggcaact ctcctagcta caatccccct gccggcatct ccccatctga ctggctgaac       60

ctgctgcagt ccgcccagcg cctgaatcca aggcctagcc catccgactt cacagatctg      120

aagaactata tccactggtt tcacaagacc cagaagaagc cttggacctt cacaagcgga      180

ggaccaacat cctgcccacc aggcagattt ggaagggtgc cactggtgct ggccaccctg      240

aacgaggtgc tgtccaatga gggaggagca cctggagcct ctgccccaga ggagcagcct      300

ccaccctacg accctccagc catcctgccc atcatctccg agggaaacag gaataggcac      360

agggcatggg cactgaggga gctgcaggat atcaagaagg agatcgagaa taaggcccct      420

ggctctcaag tgtggatcca gacactgcgg ctggccatcc tgcaggcaga cccaacccct      480

gcagatctgg agcagctgtg ccagtacatc gccagccctg tggaccagac cgcccacatg      540

acatccctga ccgcagcaat cgcagcagca gaggcagcaa cacccagcag agtgctgacc      600

cctaagaccg gcacactgac ccagcagtct gcccagccaa acgcaggcga tctgaggagc      660

cagtatcaga atctgtggct gcaggccggc aagatctccc tgctggtgct gcagctgcag      720

ccctggtcta ccatcgtgca gggacctgca gagagctccg tggagtttgt gaaccgcctg      780

cagatctccc tggccgacaa cctgccagat ggcgtgctgc ggaatcccct gctgacacct      840

ctggtcatgc agatgctgac cgagtctgtg agcaagttct gcaggggaga ggccagcgga      900

aggggaggag ccaagacagc aggactgaga accatcggac cacctaggat gaagcagcct      960

gccctgctgg tgcacacccc aggaccaaag atgcctggac cacgccagcc agcacctaag     1020

aggccaccac ctggaccttg ctacagatgt ctgaaggagg gacactgggc cagggactgc     1080

ccaacaaagg caaccggccc accacctgga ccatgcccca tctgtaagga cccaagccac     1140

tggaagcgcg attgtcccac actgaagtcc aagaattaat agagggggga cttagcgccc     1200

cccaaaccat aacacctata acagattctc ttagtgaggc cgaattagaa tgcttactct     1260

ctattcctct ggcccggagc cgccctagcg tggccgtgta cctgagcggc ccttggctgc     1320

aaccttctca gaaccaggcc ctgatgctgg ttgatacagg cgccgagaac accgtgctgc     1380

ctcagaattg gctggtgcgg gactacccca gaatccctgc cgctgtgctg ggagccggag     1440

gcgtgtcccg gaacagatac aactggctgc agggccctct tacactggct ctgaaacctg     1500

aaggcccatt catcaccatc ccaaagatcc tggtcgacac cttcgacaag tggcagatcc     1560

tgggcagaga tgtgctgagc agactgcagg ccagcatcag catccccgag gaagtgcggc     1620

cccccgtggt gggcgtcttg gatgcccccc cgagccacat tggattagaa catctgcccc     1680

ccccacctga ggtgcctcaa ttccctttaa actagaggtg ccccagccat cctgcccatc     1740

atctccggcg gcagcccaaa gaagaagcgg aaggtctcta gacaagagat caagagaatc     1800

aacaagatca gaaggagact ggtcaaggac agcaacacaa agaaggccgg caagacaggc     1860

cccatgaaaa ccctgctcgt cagagtgatg acccctgacc tgagagagcg gctggaaaac     1920

ctgagaaaga agcccgagaa catccctcag cctatcagca acaccagcag ggccaacctg     1980

aacaagctgc tgaccgacta caccgagatg aagaaagcca tcctgcacgt gtactgggaa     2040

gagttccaga aagaccccgt gggcctgatg agcagagttg ctcagcctgc cagcaagaag     2100

atcgaccaga acaagctgaa gcccgagatg gacgagaagg gcaatctgac cacagccggc     2160

tttgcctgct ctcagtgtgg ccagcctctg ttcgtgtaca agctggaaca ggtgtccgag     2220

aaaggcaagg cctacaccaa ctacttcggc agatgtaacg tggccgagca cgagaagctg     2280

attctgctgg cccagctgaa acctgagaag gactctgatg aggccgtgac ctacagcctg     2340

ggcaagtttg gacagagagc cctggacttc tacagcatcc acgtgaccaa agaaagcaca     2400

caccccgtga agcccctggc tcagatcgcc ggcaatagat acgcctctgg acctgtgggc     2460

aaagccctgt ccgatgcctg catgggaaca atcgccagct tcctgagcaa gtaccaggac     2520

atcatcatcg agcaccagaa ggtggtcaag ggcaaccaga agagactgga aagcctgagg     2580

gagctggccg gcaaagagaa cctggaatac cccagcgtga ccctgcctcc tcagcctcac     2640

acaaaagaag gcgtggacgc ctacaacgaa gtgatcgcca gagtgagaat gtgggtcaac     2700

ctgaacctgt ggcagaagct gaaactgtcc agggacgacg ccaagcctct gctgagactg     2760

aagggcttcc ctagcttccc tctggtggaa agacaggcca atgaagtgga ttggtgggac     2820

atggtctgca acgtgaagaa gctgatcaac gagaagaaag aggatggcaa ggttttctgg     2880

cagaacctgg ccggctacaa gagacaagaa gccctgaggc cttacctgag cagcgaagag     2940

gaccggaaga agggcaagaa gttcgccaga taccagctgg gcgacctgct gctgcacctg     3000

gaaaagaagc acggcgagga ctggggcaaa gtgtacgatg aggcctggga gagaatcgac     3060

aagaaggtgg aaggcctgag caagcacatt aagctggaag aggaaagaag gagcgaggac     3120

gcccaatcta aagccgctct gaccgattgg ctgagagcca aggccagctt tgtgatcgag     3180

ggcctgaaag aggccgacaa ggacgagttc tgcagatgcg agctgaagct gcagaagtgg     3240

tacggcgatc tgagaggcaa gcccttcgcc attgaggccg agaacagcat cctggacatc     3300

agcggcttca gcaagcagta caactgcgcc ttcatttggc agaaagacgg cgtcaagaaa     3360

ctgaacctgt acctgatcat caattacttc aaaggcggca agctgcggtt caagaagatc     3420

aaacccgagg ccttcgaggc taacagattc tacaccgtga tcaacaaaaa gtccggcgag     3480

atcgtgccca tggaagtgaa cttcaacttc gacgacccca acctgattat cctgcctctg     3540

gccttcggca agagacaggg cagagagttc atctggaacg atctgctgag cctggaaacc     3600

ggctctctga agctggccaa tggcagagtg atcgagaaaa ccctgtacaa caggagaacc     3660

agacaggacg agcctgctct gtttgtggcc ctgaccttcg agagaagaga ggtgctggac     3720

agcagcaaca tcaagcccat gaacctgatc ggcgtggacc ggggcgagaa tatccctgct     3780

gtgatcgccc tgacagaccc tgaaggatgc ccactgagca gattcaagga ctccctgggc     3840

aaccctacac acatcctgag aatcggcgag agctacaaag agaagcagag gacaatccag     3900

gccaagaaag aggtggaaca gagaagagcc ggcggatact ctaggaagta cgccagcaag     3960

gccaagaatc tggccgacga catggtccga aacaccgcca gagatctgct gtactacgcc     4020

gtgacacagg acgccatgct gatcttcgag aatctgagca gaggcttcgg ccggcagggc     4080

aagagaacct ttatggccga gaggcagtac accagaatgg aagattggct cacagctaaa     4140

ctggcctacg agggactgag caagacctac ctgtccaaaa cactggccca gtatacctcc     4200

aagacctgca gcaattgcgg cttcaccatc accagcgccg actacgacag agtgctggaa     4260

aagctcaaga aaaccgccac cggctggatg accaccatca acggcaaaga gctgaaggtt     4320

gagggccaga tcacctacta caacaggtac aagaggcaga acgtcgtgaa ggatctgagc     4380

gtggaactgg acagactgag cgaagagagc gtgaacaacg acatcagcag ctggacaaag     4440

ggcagatcag gcgaggctct gagcctgctg aagaagaggt ttagccacag acctgtgcaa     4500

gagaagttcg tgtgcctgaa ctgcggcttc gagacacacg ccgatgaaca ggctgccctg     4560

aacattgcca gaagctggct gttcctgaga agccaagagt acaagaagta ccagaccaac     4620

aagaccaccg gcaacaccga caagagggcc tttgtggaaa cctggcagag cttctacaga     4680

aaaaagctga aagaagtctg gaagcccgcc gtgactagtc caaaaaagaa gagaaaggta     4740

gccctcgagt acccatatga tgtccctgac tacgcttga                            4779


<210>  888
<211>  5078
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP46 plasmid sequence

<400>  888
atgggtcaga ttttcagcag aagcgcctcc cctattccta gacctccacg gggcctggcc       60

gcccaccact ggctgaattt cctgcaggcc gcttatagac tggagcctgg accttccagc      120

tacgacttcc accagctgaa gaaattcctg aagatcgccc tggaaacccc tgccagaatc      180

tgccctatca actacagcct gctggcctcc ctgctgccca agggctaccc tggcagagtg      240

aacgagatcc ttcatatcct gatccagaca caggctcaga tcccctctag gcccgctcca      300

cctcctccaa gcagcccaac ccacgatcct cctgatagcg accctcagat ccccccacca      360

tacgtggagc ccaccgcccc tcaagtgctg ccagtgatgc acccccacgg cgcccctcct      420

aatcacagac cttggcagat gaaagacctg caggccatca agcaggaagt gtcccaggcc      480

gctcctggca gcccccaatt tatgcagacc atcagactcg ccgttcagca gttcgacccc      540

acagccaagg atctgcagga cctgctgcag tacctgtgta gcagcctggt cgccagcctg      600

caccatcagc aactggattc tctgatcagc gaggccgaga caagaggcat caccggctac      660

aaccctctgg ccggccccct gcgggtgcag gcaaacaacc cccagcagca ggggctgcgg      720

agagagtacc agcagctgtg gctggctgct ttcgccgcac tgcctggaag cgccaaagat      780

ccatcttggg cctctatcct gcagggcctg gaagaacctt accacgcctt tgtggaaaga      840

ctgaacatcg ccctggacaa cggcctgcct gagggcaccc ctaaggaccc catcctgaga      900

tctctggcct acagcaacgc caacaaggaa tgtcagaagc tgctgcaagc cagaggccac      960

accaacagcc ccctgggcga catgctgcgc gcctgccaga cctggacccc taaggacaag     1020

accaaggtgc tggtggtgca gcctaagaag cctcccccta atcagccctg cttccggtgc     1080

ggcaaggccg gacactggag ccgggactgc acccagcctc ggcctccacc gggaccttgt     1140

cctctgtgcc aagaccccac acactggaag agagattgcc cccgcctaaa gcccactatc     1200

ccagaaccag agccagagga agatgccctc ctattagacc tccccgctga cattccacac     1260

ccaaaaaact ccataggggg ggaggtttaa cctctcctcc taccctgcag caggtgttcc     1320

tgaatcaaga tcctgccagc atcctgcctg tgatccccct cgaccccgct agaagacctg     1380

tgatcaaggc ccaggtggac acacagacct cccaccccaa aacaatcgag gccctgctgg     1440

acaccggcgc tgatatgaca gtgctgccaa tcgccctgtt cagcagcaac acccctctga     1500

aaaacaccag cgtgctcgga gccggcggac agacccagga ccacttcaag ctgacaagcc     1560

tgcctgtcct gatccggctg cccttcagaa ccacacctat cgtgctgacc agctgcctgg     1620

tggacacaaa gaacaactgg gccatcatcg gcagggacgc cctgcaacag tgccagggcg     1680

tgctgtacct gccagaggcc aagggccccc ccgttatcct gcctatccag gcccctgccg     1740

tgctgggcct ggaacacctg ccaagacccc cccagatcag ccaatttcct ctgaaccaga     1800

acgccagcag accatgtaat acctggtccg gcagaccttg gcggcaggcc atttctaacc     1860

ccacccccgg ccaggagatc acccagtaca gccagctgaa gcggcctatg gaacctggag     1920

attctagcac cacctgcggc cctctgacac tgtgaccata gacctctcat catcttcccc     1980

cgggccccct gacttgtcca gcctgccaac cacacggtgc ccctcaagtg ctgccagtga     2040

tgcacggcgg cagcccaaag aagaagcgga aggtctctag acaagagatc aagagaatca     2100

acaagatcag aaggagactg gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc     2160

ccatgaaaac cctgctcgtc agagtgatga cccctgacct gagagagcgg ctggaaaacc     2220

tgagaaagaa gcccgagaac atccctcagc ctatcagcaa caccagcagg gccaacctga     2280

acaagctgct gaccgactac accgagatga agaaagccat cctgcacgtg tactgggaag     2340

agttccagaa agaccccgtg ggcctgatga gcagagttgc tcagcctgcc agcaagaaga     2400

tcgaccagaa caagctgaag cccgagatgg acgagaaggg caatctgacc acagccggct     2460

ttgcctgctc tcagtgtggc cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga     2520

aaggcaaggc ctacaccaac tacttcggca gatgtaacgt ggccgagcac gagaagctga     2580

ttctgctggc ccagctgaaa cctgagaagg actctgatga ggccgtgacc tacagcctgg     2640

gcaagtttgg acagagagcc ctggacttct acagcatcca cgtgaccaaa gaaagcacac     2700

accccgtgaa gcccctggct cagatcgccg gcaatagata cgcctctgga cctgtgggca     2760

aagccctgtc cgatgcctgc atgggaacaa tcgccagctt cctgagcaag taccaggaca     2820

tcatcatcga gcaccagaag gtggtcaagg gcaaccagaa gagactggaa agcctgaggg     2880

agctggccgg caaagagaac ctggaatacc ccagcgtgac cctgcctcct cagcctcaca     2940

caaaagaagg cgtggacgcc tacaacgaag tgatcgccag agtgagaatg tgggtcaacc     3000

tgaacctgtg gcagaagctg aaactgtcca gggacgacgc caagcctctg ctgagactga     3060

agggcttccc tagcttccct ctggtggaaa gacaggccaa tgaagtggat tggtgggaca     3120

tggtctgcaa cgtgaagaag ctgatcaacg agaagaaaga ggatggcaag gttttctggc     3180

agaacctggc cggctacaag agacaagaag ccctgaggcc ttacctgagc agcgaagagg     3240

accggaagaa gggcaagaag ttcgccagat accagctggg cgacctgctg ctgcacctgg     3300

aaaagaagca cggcgaggac tggggcaaag tgtacgatga ggcctgggag agaatcgaca     3360

agaaggtgga aggcctgagc aagcacatta agctggaaga ggaaagaagg agcgaggacg     3420

cccaatctaa agccgctctg accgattggc tgagagccaa ggccagcttt gtgatcgagg     3480

gcctgaaaga ggccgacaag gacgagttct gcagatgcga gctgaagctg cagaagtggt     3540

acggcgatct gagaggcaag cccttcgcca ttgaggccga gaacagcatc ctggacatca     3600

gcggcttcag caagcagtac aactgcgcct tcatttggca gaaagacggc gtcaagaaac     3660

tgaacctgta cctgatcatc aattacttca aaggcggcaa gctgcggttc aagaagatca     3720

aacccgaggc cttcgaggct aacagattct acaccgtgat caacaaaaag tccggcgaga     3780

tcgtgcccat ggaagtgaac ttcaacttcg acgaccccaa cctgattatc ctgcctctgg     3840

ccttcggcaa gagacagggc agagagttca tctggaacga tctgctgagc ctggaaaccg     3900

gctctctgaa gctggccaat ggcagagtga tcgagaaaac cctgtacaac aggagaacca     3960

gacaggacga gcctgctctg tttgtggccc tgaccttcga gagaagagag gtgctggaca     4020

gcagcaacat caagcccatg aacctgatcg gcgtggaccg gggcgagaat atccctgctg     4080

tgatcgccct gacagaccct gaaggatgcc cactgagcag attcaaggac tccctgggca     4140

accctacaca catcctgaga atcggcgaga gctacaaaga gaagcagagg acaatccagg     4200

ccaagaaaga ggtggaacag agaagagccg gcggatactc taggaagtac gccagcaagg     4260

ccaagaatct ggccgacgac atggtccgaa acaccgccag agatctgctg tactacgccg     4320

tgacacagga cgccatgctg atcttcgaga atctgagcag aggcttcggc cggcagggca     4380

agagaacctt tatggccgag aggcagtaca ccagaatgga agattggctc acagctaaac     4440

tggcctacga gggactgagc aagacctacc tgtccaaaac actggcccag tatacctcca     4500

agacctgcag caattgcggc ttcaccatca ccagcgccga ctacgacaga gtgctggaaa     4560

agctcaagaa aaccgccacc ggctggatga ccaccatcaa cggcaaagag ctgaaggttg     4620

agggccagat cacctactac aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg     4680

tggaactgga cagactgagc gaagagagcg tgaacaacga catcagcagc tggacaaagg     4740

gcagatcagg cgaggctctg agcctgctga agaagaggtt tagccacaga cctgtgcaag     4800

agaagttcgt gtgcctgaac tgcggcttcg agacacacgc cgatgaacag gctgccctga     4860

acattgccag aagctggctg ttcctgagaa gccaagagta caagaagtac cagaccaaca     4920

agaccaccgg caacaccgac aagagggcct ttgtggaaac ctggcagagc ttctacagaa     4980

aaaagctgaa agaagtctgg aagcccgccg tgactagtcc aaaaaagaag agaaaggtag     5040

ccctcgagta cccatatgat gtccctgact acgcttga                             5078


<210>  889
<211>  5244
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP47 plasmid sequence

<400>  889
atgggcaata gctcctctac cccccctcca agcgccctga agaactccga tctgttcaag       60

accatgctga ggacacagta cagcggctcc gtgaagacac ggagaatcaa ccaggatatc      120

aagaagcagt atccactgtg gccagaccag ggaacctgcg caacaaagca ctgggagcag      180

gccgtgctga tccccctgga ctctgtgagc gaggagaccg ccaaggtgct gaatttcctg      240

cgggtgaaga tccaggccag aaagggagag accgcaaggc agatgaccgc acacacaatc      300

aagaagctga tcgtgggcac aatcgataag aacaagcagc agaccgagat cctgcagaag      360

acagacgaga gcgatgagga gatggacacc acaaatacca tgctgtttat cgcccgcaac      420

aagagggaga ggatcgcaca gcagcagcag gcagatctgg cagcacagca gcaggtgctg      480

ctgctgcaga gggagcagca gagggagcag agagagaagg atatcaagaa gcgggacgag      540

aagaagaaga agctgctgcc cgacaccaca cagaaggtgg agcagaccga tatcggagag      600

gccagctcct ctgacgcctc cgcccagaag ccaatctcta ccgacaacaa tcccgatctg      660

aaggtggacg gcgtgctgac aagaagccag cacaccacag tgccttccaa catcaccatc      720

aagaaggatg gcacatccgt gcagtaccag caccccatca ggaactatcc taccggcgag      780

ggcaatctga cagcccaggt gcggaaccct tttagaccac tggagctgca gcagctgagg      840

aaggactgcc ccgccctgcc tgagggcatc ccacagctgg ccgagtggct gacccagaca      900

atggccatct acaattgtga cgaggccgat gtggagcagc tggccagagt gatcttccca      960

acccctgtga ggcagatcgc aggcgtgatc aacggacacg cagcagcaaa taccgcagcc     1020

aagatccaga actacgtgac agcatgcagg cagcactatc cagccgtgtg cgattggggc     1080

accatccagg cctttacata caagccccct cagaccgccc acgagtatgt gaagcacgcc     1140

gagatcatct tcaagaacaa tagcggactg gagtggcagc acgcaaccgt gccttttatc     1200

aatatggtgg tgcagggcct gccacccaag gtgacacggt ccctgatgtc tggcaaccca     1260

gattggagca ccaagacaat cccacagatc atccccctga tgcagcacta cctgaatctg     1320

cagtccagac aggacgccaa gatcaagcag acccctctgg tgctgcagct ggccatgcca     1380

gcccagacaa tgaacggcaa taagggctac gtgggctcct atcctaccaa cgagccatac     1440

tattctttcc agcagcagca gaggccagca cccagagccc ctccaggcaa cgtgccttcc     1500

aatacctgct tcttttgtaa gcagccagga cactggaagg cagactgccc taataagaca     1560

aggaacctgc gcaatatggg caacatggga aggggaggaa gaatgggagg accaccttac     1620

cggagccagc cttatccagc ctttatccag ccaccccaga atcaccagaa ccagtataat     1680

ggcaggatgg atcgctctca gctgcaggcc agcgcccagg agtggctgcc aggaacctac     1740

cctgcatgag acccaatcga ttgcccctat gagaagagcg gcacaaagac cacacaggac     1800

gtgatcacca caaagaatgc cgagatcatg gtgaccgtga accacacaaa gatcccaatg     1860

ctggtggata ccggcgcctg tctgacagca atcggaggag cagcaaccgt ggtgccagac     1920

ctgaagctga ccaacacaga gatcatcgca gtgggaatct ctgccgagcc cgtgcctcac     1980

gtgctggcca agccaaccaa gatccagatc gagaacacaa atatcgatat cagcccttgg     2040

tacaatccag accagacctt ccacatcctg ggccgcgaca cactgtctaa gatgcgggcc     2100

atcgtgagct ttgagaagaa cggcgagatg accgtgctgc tgcctccaac atatcacaag     2160

cagctgtcct gtcagaccaa gggtgccgca aggcagatga ccgcacacac aggcggcagc     2220

ccaaagaaga agcggaaggt ctctagacaa gagatcaaga gaatcaacaa gatcagaagg     2280

agactggtca aggacagcaa cacaaagaag gccggcaaga caggccccat gaaaaccctg     2340

ctcgtcagag tgatgacccc tgacctgaga gagcggctgg aaaacctgag aaagaagccc     2400

gagaacatcc ctcagcctat cagcaacacc agcagggcca acctgaacaa gctgctgacc     2460

gactacaccg agatgaagaa agccatcctg cacgtgtact gggaagagtt ccagaaagac     2520

cccgtgggcc tgatgagcag agttgctcag cctgccagca agaagatcga ccagaacaag     2580

ctgaagcccg agatggacga gaagggcaat ctgaccacag ccggctttgc ctgctctcag     2640

tgtggccagc ctctgttcgt gtacaagctg gaacaggtgt ccgagaaagg caaggcctac     2700

accaactact tcggcagatg taacgtggcc gagcacgaga agctgattct gctggcccag     2760

ctgaaacctg agaaggactc tgatgaggcc gtgacctaca gcctgggcaa gtttggacag     2820

agagccctgg acttctacag catccacgtg accaaagaaa gcacacaccc cgtgaagccc     2880

ctggctcaga tcgccggcaa tagatacgcc tctggacctg tgggcaaagc cctgtccgat     2940

gcctgcatgg gaacaatcgc cagcttcctg agcaagtacc aggacatcat catcgagcac     3000

cagaaggtgg tcaagggcaa ccagaagaga ctggaaagcc tgagggagct ggccggcaaa     3060

gagaacctgg aataccccag cgtgaccctg cctcctcagc ctcacacaaa agaaggcgtg     3120

gacgcctaca acgaagtgat cgccagagtg agaatgtggg tcaacctgaa cctgtggcag     3180

aagctgaaac tgtccaggga cgacgccaag cctctgctga gactgaaggg cttccctagc     3240

ttccctctgg tggaaagaca ggccaatgaa gtggattggt gggacatggt ctgcaacgtg     3300

aagaagctga tcaacgagaa gaaagaggat ggcaaggttt tctggcagaa cctggccggc     3360

tacaagagac aagaagccct gaggccttac ctgagcagcg aagaggaccg gaagaagggc     3420

aagaagttcg ccagatacca gctgggcgac ctgctgctgc acctggaaaa gaagcacggc     3480

gaggactggg gcaaagtgta cgatgaggcc tgggagagaa tcgacaagaa ggtggaaggc     3540

ctgagcaagc acattaagct ggaagaggaa agaaggagcg aggacgccca atctaaagcc     3600

gctctgaccg attggctgag agccaaggcc agctttgtga tcgagggcct gaaagaggcc     3660

gacaaggacg agttctgcag atgcgagctg aagctgcaga agtggtacgg cgatctgaga     3720

ggcaagccct tcgccattga ggccgagaac agcatcctgg acatcagcgg cttcagcaag     3780

cagtacaact gcgccttcat ttggcagaaa gacggcgtca agaaactgaa cctgtacctg     3840

atcatcaatt acttcaaagg cggcaagctg cggttcaaga agatcaaacc cgaggccttc     3900

gaggctaaca gattctacac cgtgatcaac aaaaagtccg gcgagatcgt gcccatggaa     3960

gtgaacttca acttcgacga ccccaacctg attatcctgc ctctggcctt cggcaagaga     4020

cagggcagag agttcatctg gaacgatctg ctgagcctgg aaaccggctc tctgaagctg     4080

gccaatggca gagtgatcga gaaaaccctg tacaacagga gaaccagaca ggacgagcct     4140

gctctgtttg tggccctgac cttcgagaga agagaggtgc tggacagcag caacatcaag     4200

cccatgaacc tgatcggcgt ggaccggggc gagaatatcc ctgctgtgat cgccctgaca     4260

gaccctgaag gatgcccact gagcagattc aaggactccc tgggcaaccc tacacacatc     4320

ctgagaatcg gcgagagcta caaagagaag cagaggacaa tccaggccaa gaaagaggtg     4380

gaacagagaa gagccggcgg atactctagg aagtacgcca gcaaggccaa gaatctggcc     4440

gacgacatgg tccgaaacac cgccagagat ctgctgtact acgccgtgac acaggacgcc     4500

atgctgatct tcgagaatct gagcagaggc ttcggccggc agggcaagag aacctttatg     4560

gccgagaggc agtacaccag aatggaagat tggctcacag ctaaactggc ctacgaggga     4620

ctgagcaaga cctacctgtc caaaacactg gcccagtata cctccaagac ctgcagcaat     4680

tgcggcttca ccatcaccag cgccgactac gacagagtgc tggaaaagct caagaaaacc     4740

gccaccggct ggatgaccac catcaacggc aaagagctga aggttgaggg ccagatcacc     4800

tactacaaca ggtacaagag gcagaacgtc gtgaaggatc tgagcgtgga actggacaga     4860

ctgagcgaag agagcgtgaa caacgacatc agcagctgga caaagggcag atcaggcgag     4920

gctctgagcc tgctgaagaa gaggtttagc cacagacctg tgcaagagaa gttcgtgtgc     4980

ctgaactgcg gcttcgagac acacgccgat gaacaggctg ccctgaacat tgccagaagc     5040

tggctgttcc tgagaagcca agagtacaag aagtaccaga ccaacaagac caccggcaac     5100

accgacaaga gggcctttgt ggaaacctgg cagagcttct acagaaaaaa gctgaaagaa     5160

gtctggaagc ccgccgtgac tagtccaaaa aagaagagaa aggtagccct cgagtaccca     5220

tatgatgtcc ctgactacgc ttga                                            5244


<210>  890
<211>  4962
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP48 plasmid sequence

<400>  890
atgggccaga caatcacaac ccctctgagc ctgaccctgg accactggag tgaagtgcgg       60

gctagagccc acaaccaggg cgtggaagtc cggaaaaaaa agtggatcac cctgtgcgag      120

gccgagtggg tcatgatgaa cgtgggatgg cctagagagg gtacatttag cctggacaac      180

atcagccagg ttgagaaaaa gattttcgct cctggccctt acggccatcc tgaccaggtg      240

ccttacatca ccacatggcg gagcctggct accgacccac caagctgggt gcggcccttc      300

ctgcctcctc ccaagccccc cacccctctg cctcagcctc tgagccccca gccctctgcc      360

cctctgacca gctctctgta ccctgtgctg cctaagtccg atccccctaa acctcctgtt      420

ttacctcccg accctagcag cccactgatc gacctgctga cggaagaacc tcctccttat      480

cctggcggac atggcccccc accttctggc cctcggaccc caaccgcctc ccctatcgcc      540

tctagactga gagagcggag agaaaacccc gccgaagagt cccaagccct gcccctgaga      600

gagggcccta acaaccggcc tcagtactgg cccttcagcg ccagcgatct gtataactgg      660

aagtcccaca atcctccttt cagccaggat cctgtggccc tgacaaacct gatcgagtct      720

atcctggtga ctcaccagcc aacctgggat gactgccagc agctgctgca ggccctcctg      780

accggcgaag agagacagag agtgctgctg gaggccagaa agcaggtgcc tggagaggac      840

ggcaggccta cccagctgcc taatgtgatc gacgagacat tccccctgac cagaccaaat      900

tgggacttcg ccaccccagc tggcagagag cacctgcgcc tgtaccggca gcttctgctg      960

gccggactga gaggcgctgc cagaagacca accaacctgg ctcaggtgaa gcaggtcgtg     1020

cagggcaaag aggagacacc cgccgctttc ctggaacggc tgaaggaggc ctacagaatg     1080

tacacccctt acgaccccga agatccagga caggccgcca gcgtgatcct gagcttcatc     1140

taccagagca gccctgacat cagaaacaag ctgcagcggc tggaaggcct gcagggcttc     1200

acactgagcg acctgctcaa ggaggccgag aagatctaca acaagcggga aacccctgag     1260

gaaagagaag agagattgtg gcagcggcaa gaggagcggg acaaaaagcg gcacaaggaa     1320

atgaccaagg tgctggctac cgtggtggcc cagaacagag ataaagacag agaggaatcg     1380

aagctgggcg accagagaaa gatccccctt ggcaaggacc aatgtgccta ctgcaaggaa     1440

aaaggccact gggtgaggga ctgtcccaag agacccagaa agaagcccgc aaacagcaca     1500

ctgctgaacc tgggcgatca ggagagccaa ggccaggacc cccctcctga gcctagaatc     1560

accctgaaga ttggaggcca gcctgtgacc tttctggtgg acaccggcgc ccaacactct     1620

gtgctgacca gacctgatgg ccccctcagc gatagaaccg ccctggtcca gggagctaca     1680

ggcagcaaga actacagatg gaccaccgac agaagggtgc agctggctac tggcaaggtg     1740

acacacagct ttctgtacgt gcccgagtgc ccttaccccc tcctgggcag agatctgttg     1800

acaaagctga aggcccaaat ccacttcacc ggagagggcg ctaatgtggt gggccccaag     1860

ggcctgcctc ttcaggtgct gacactgcaa ctggaagagg gtgccagctc tctgtaccct     1920

gtgctgcctg gcggcagccc aaagaagaag cggaaggtct ctagacaaga gatcaagaga     1980

atcaacaaga tcagaaggag actggtcaag gacagcaaca caaagaaggc cggcaagaca     2040

ggccccatga aaaccctgct cgtcagagtg atgacccctg acctgagaga gcggctggaa     2100

aacctgagaa agaagcccga gaacatccct cagcctatca gcaacaccag cagggccaac     2160

ctgaacaagc tgctgaccga ctacaccgag atgaagaaag ccatcctgca cgtgtactgg     2220

gaagagttcc agaaagaccc cgtgggcctg atgagcagag ttgctcagcc tgccagcaag     2280

aagatcgacc agaacaagct gaagcccgag atggacgaga agggcaatct gaccacagcc     2340

ggctttgcct gctctcagtg tggccagcct ctgttcgtgt acaagctgga acaggtgtcc     2400

gagaaaggca aggcctacac caactacttc ggcagatgta acgtggccga gcacgagaag     2460

ctgattctgc tggcccagct gaaacctgag aaggactctg atgaggccgt gacctacagc     2520

ctgggcaagt ttggacagag agccctggac ttctacagca tccacgtgac caaagaaagc     2580

acacaccccg tgaagcccct ggctcagatc gccggcaata gatacgcctc tggacctgtg     2640

ggcaaagccc tgtccgatgc ctgcatggga acaatcgcca gcttcctgag caagtaccag     2700

gacatcatca tcgagcacca gaaggtggtc aagggcaacc agaagagact ggaaagcctg     2760

agggagctgg ccggcaaaga gaacctggaa taccccagcg tgaccctgcc tcctcagcct     2820

cacacaaaag aaggcgtgga cgcctacaac gaagtgatcg ccagagtgag aatgtgggtc     2880

aacctgaacc tgtggcagaa gctgaaactg tccagggacg acgccaagcc tctgctgaga     2940

ctgaagggct tccctagctt ccctctggtg gaaagacagg ccaatgaagt ggattggtgg     3000

gacatggtct gcaacgtgaa gaagctgatc aacgagaaga aagaggatgg caaggttttc     3060

tggcagaacc tggccggcta caagagacaa gaagccctga ggccttacct gagcagcgaa     3120

gaggaccgga agaagggcaa gaagttcgcc agataccagc tgggcgacct gctgctgcac     3180

ctggaaaaga agcacggcga ggactggggc aaagtgtacg atgaggcctg ggagagaatc     3240

gacaagaagg tggaaggcct gagcaagcac attaagctgg aagaggaaag aaggagcgag     3300

gacgcccaat ctaaagccgc tctgaccgat tggctgagag ccaaggccag ctttgtgatc     3360

gagggcctga aagaggccga caaggacgag ttctgcagat gcgagctgaa gctgcagaag     3420

tggtacggcg atctgagagg caagcccttc gccattgagg ccgagaacag catcctggac     3480

atcagcggct tcagcaagca gtacaactgc gccttcattt ggcagaaaga cggcgtcaag     3540

aaactgaacc tgtacctgat catcaattac ttcaaaggcg gcaagctgcg gttcaagaag     3600

atcaaacccg aggccttcga ggctaacaga ttctacaccg tgatcaacaa aaagtccggc     3660

gagatcgtgc ccatggaagt gaacttcaac ttcgacgacc ccaacctgat tatcctgcct     3720

ctggccttcg gcaagagaca gggcagagag ttcatctgga acgatctgct gagcctggaa     3780

accggctctc tgaagctggc caatggcaga gtgatcgaga aaaccctgta caacaggaga     3840

accagacagg acgagcctgc tctgtttgtg gccctgacct tcgagagaag agaggtgctg     3900

gacagcagca acatcaagcc catgaacctg atcggcgtgg accggggcga gaatatccct     3960

gctgtgatcg ccctgacaga ccctgaagga tgcccactga gcagattcaa ggactccctg     4020

ggcaacccta cacacatcct gagaatcggc gagagctaca aagagaagca gaggacaatc     4080

caggccaaga aagaggtgga acagagaaga gccggcggat actctaggaa gtacgccagc     4140

aaggccaaga atctggccga cgacatggtc cgaaacaccg ccagagatct gctgtactac     4200

gccgtgacac aggacgccat gctgatcttc gagaatctga gcagaggctt cggccggcag     4260

ggcaagagaa cctttatggc cgagaggcag tacaccagaa tggaagattg gctcacagct     4320

aaactggcct acgagggact gagcaagacc tacctgtcca aaacactggc ccagtatacc     4380

tccaagacct gcagcaattg cggcttcacc atcaccagcg ccgactacga cagagtgctg     4440

gaaaagctca agaaaaccgc caccggctgg atgaccacca tcaacggcaa agagctgaag     4500

gttgagggcc agatcaccta ctacaacagg tacaagaggc agaacgtcgt gaaggatctg     4560

agcgtggaac tggacagact gagcgaagag agcgtgaaca acgacatcag cagctggaca     4620

aagggcagat caggcgaggc tctgagcctg ctgaagaaga ggtttagcca cagacctgtg     4680

caagagaagt tcgtgtgcct gaactgcggc ttcgagacac acgccgatga acaggctgcc     4740

ctgaacattg ccagaagctg gctgttcctg agaagccaag agtacaagaa gtaccagacc     4800

aacaagacca ccggcaacac cgacaagagg gcctttgtgg aaacctggca gagcttctac     4860

agaaaaaagc tgaaagaagt ctggaagccc gccgtgacta gtccaaaaaa gaagagaaag     4920

gtagccctcg agtacccata tgatgtccct gactacgctt ga                        4962


<210>  891
<211>  5061
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP49 plasmid sequence

<400>  891
atgggccaga ccgtgaccac acccctgtcc ctgacactgg gccactggaa ggacgtggag       60

cggatcgccc acaatcagtc tgtggatgtg aagaagcgga gatgggtgac cttctgcagc      120

gccgagtggc ccaccttcaa cgtgggctgg ccaagggacg gcaccttcaa ccgcgatctg      180

atcacacagg tgaagatcaa ggtgtttagc ccaggacctc acggacaccc agaccaggtg      240

ccttatatcg tgacctggga ggccctggcc ttcgatccac ctccatgggt gaagccattt      300

gtgcacccaa agccacctcc accactgcct ccatccgccc cttctctgcc actggagcca      360

cctcggtcca ccccaccaag aagctccctg tatcctgccc tgacaccatc tctgggcgcc      420

aagccaaagc cacaggtgct gtctgacagc ggaggacctc tgatcgacct gctgaccgag      480

gatcctccac cctacagaga tccaaggcct ccaccatccg acagggatgg aaacggagga      540

gaggcaacac cagcaggaga ggcccctgac ccatccccca tggcctctag actgaggggc      600

aggcgcgagc ctccagtggc agatagcacc acatcccagg cattcccact gagggcagga      660

ggaaatggcc agctgcagta ttggcccttt tctagctccg acctgtacaa ctggaagaac      720

aataacccat ccttctctga ggatcccggc aagctgaccg ccctgatcga gagcgtgctg      780

atcacccacc agcccacatg ggacgattgt cagcagctgc tgggcaccct gctgacaggc      840

gaggagaagc agcgggtgct gctggaggca aggaaggccg tgagaggcga cgatggcaga      900

cccacccagc tgcctaatga ggtggacgca gcatttccac tggagaggcc agactgggat      960

tataccacac aggccggcag gaaccacctg gtgcactaca ggcagctgct gctggccgga     1020

ctgcagaatg caggcaggtc ccctaccaac ctggccaagg tgaagggcat cacacagggc     1080

cctaatgaga gcccatccgc ctttctggag cgcctgaagg aggcctaccg gagatatacc     1140

ccctacgacc ctgaggatcc aggccaggag acaaacgtgt ctatgagctt catctggcag     1200

tctgccccag acatcggaag gaagctggag cgcctggagg acctgaagaa taagaccctg     1260

ggcgatctgg tgcgggaggc agagaagatc ttcaacaaga gagagacacc tgaggagagg     1320

gaggagcgga tcaggaggga gaccgaggag aaggaggagc ggagaaggac agaggacgag     1380

cagaaggaga aggagcggga tcgccggaga cacagagaga tgagcaagct gctggccacc     1440

gtggtgtccg gacagaagca ggacaggcag ggaggagaga ggcgccggtc tcagctggac     1500

cgcgatcagt gcgcctactg taaggagaag ggccactggg ccaaggattg ccccaagaag     1560

cctagaggcc caaggggccc taggccacag accagcctgc tgacactgga cgattgagga     1620

ggacagggac aggagccacc tccagagccc agaatcaccc tgaaggtcgg cggccagcct     1680

gtgacctttc tggtggacac aggcgcccag cacagcgtgc tgacccagaa tcccggccct     1740

ctgtctgata agagcgcctg ggtgcaggga gcaacaggcg gcaagcggta cagatggacc     1800

acagaccgga aggtgcacct ggccaccggc aaggtgacac acagctttct gcacgtgccc     1860

gactgtccat accccctgct gggcagagat ctgctgacca agctgaaggc acagatccac     1920

ttcgagggat ccggagcaca ggtcatggga ccaatgggac agcctctgca ggtgctgaca     1980

ctgaacatcg aggatgaggg tgccagctcc ctgtatcctg ccctgacagg cggcagccca     2040

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     2100

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     2160

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     2220

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     2280

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     2340

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     2400

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     2460

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     2520

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     2580

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     2640

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     2700

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2760

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2820

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2880

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2940

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     3000

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     3060

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     3120

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     3180

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     3240

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     3300

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     3360

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     3420

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     3480

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     3540

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     3600

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     3660

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3720

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3780

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3840

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3900

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3960

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     4020

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     4080

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     4140

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     4200

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     4260

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     4320

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     4380

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     4440

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     4500

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     4560

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     4620

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     4680

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4740

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4800

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4860

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4920

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4980

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     5040

gatgtccctg actacgcttg a                                               5061


<210>  892
<211>  4757
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP50 plasmid sequence

<400>  892
atggtgtctc tggacaggga tatggcaagg caggtgagcg gaggcaagag ggattaccca       60

gagctggaga agtgcatcaa gcacgcctgt aagatcaagg tgcggctgag aggagagcac      120

ctgaccgagg gcaactgcct gtggtgtctg aagacactgg actatatgtt cgaggatcac      180

aaggaggagc cctggaccaa ggtgaagttt agaacaatct ggcagaaggt gaagaacctg      240

acccctgagg agagcaataa gaaggacttc atgtccctgc aggccacact ggccggcctg      300

atgtgctgtc agatgggcat gaggccagag accctgcagg acgccatggc cacagtgatc      360

atgaaggatg gcctgctgga gcaggaggag aagaaggagg ataagcgcga gaaggaggag      420

agcgtgtttc caatcgtggt gcaggcagca ggaggccggt cctggaaggc cgtggactct      480

gtgatgttcc agcagctgca gaccgtggca atgcagcacg gactggtgag cgaggatttt      540

gagagacagc tggcctacta tgccaccaca tggacatcca aggacatcct ggaggtgctg      600

gccatgatgc ccggcaacag agcccagaag gagctgatcc agggcaagct gaatgaggag      660

gccgagaggt ggcggagaaa caatccacct ccaccagcag gaggaggact gaccgtggat      720

cagatcatgg gagtgggaca gacaaaccag gcagcagcac aggcaaatat ggaccaggcc      780

agacagatct gcctgcagtg ggtcatcaac gcactgaggg ccgtgagaca catggcacac      840

aggcccggca accctatgct ggtgaagcag aagaccaatg agccttacga ggacttcgcc      900

gccagactgc tggaggccat cgatgccgag ccagtgacac agcccatcaa ggactacctg      960

aagctgaccc tgagctatac aaatgcctcc gccgactgcc agaagcagat ggatagaacc     1020

ctgggacaga gggtgcagca ggcctccgtg gaggagaaga tgcaggcctg tagggatgtg     1080

ggctctgagg gctttaagat gcagctgctg gcccaggccc tgaggcctgg caagggcaag     1140

ggaaacggac agccacagcg gtgctacaat tgtggcaagc caggacacca ggcaaggcag     1200

tgcaggcagg gcatcatatg tcacaactgt ggaaagagag gacatatgca aaaagaatgc     1260

agaggaaaga gagacataag gggaaaacag cagggaaacg ggaggagggg gatacgtgtg     1320

gtgccgtccg ctcctcctat ggaataacaa gcgcccctcc aatggtgcag gtgcggattg     1380

gatctcagca gcgcaacctg ctgttcgaca ccggcgccga tagaaccatc gtccggtggc     1440

acgagggctc cggcaacccc gccggcagaa tcaaactgca aggcatcggc ggaatcgtgg     1500

aaggcgagaa gtggaacaac gtggagctgg aatacaaggg cgagacaaga aagggcacca     1560

tcgtggtgct gcctcagagc cctgtggagg tgctgggacg ggacaacatg gcccggttcg     1620

gcatcaagat catcatggct aatctggagg aaaaaagaat ccccatcacc aaggtgaagt     1680

tgaaagaggg atgtggtgcc gcaggaggcc ggtcctggaa ggccggcggc agcccaaaga     1740

agaagcggaa ggtctctaga caagagatca agagaatcaa caagatcaga aggagactgg     1800

tcaaggacag caacacaaag aaggccggca agacaggccc catgaaaacc ctgctcgtca     1860

gagtgatgac ccctgacctg agagagcggc tggaaaacct gagaaagaag cccgagaaca     1920

tccctcagcc tatcagcaac accagcaggg ccaacctgaa caagctgctg accgactaca     1980

ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg     2040

gcctgatgag cagagttgct cagcctgcca gcaagaagat cgaccagaac aagctgaagc     2100

ccgagatgga cgagaagggc aatctgacca cagccggctt tgcctgctct cagtgtggcc     2160

agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa aggcaaggcc tacaccaact     2220

acttcggcag atgtaacgtg gccgagcacg agaagctgat tctgctggcc cagctgaaac     2280

ctgagaagga ctctgatgag gccgtgacct acagcctggg caagtttgga cagagagccc     2340

tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag cccctggctc     2400

agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc gatgcctgca     2460

tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag caccagaagg     2520

tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc aaagagaacc     2580

tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc gtggacgcct     2640

acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg cagaagctga     2700

aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct agcttccctc     2760

tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc     2820

tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc ggctacaaga     2880

gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag ggcaagaagt     2940

tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac ggcgaggact     3000

ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca     3060

agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa gccgctctga     3120

ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag gccgacaagg     3180

acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg agaggcaagc     3240

ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc aagcagtaca     3300

actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac ctgatcatca     3360

attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc ttcgaggcta     3420

acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact     3480

tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag agacagggca     3540

gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg     3600

gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag cctgctctgt     3660

ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc aagcccatga     3720

acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg acagaccctg     3780

aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac atcctgagaa     3840

tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag gtggaacaga     3900

gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg gccgacgaca     3960

tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac gccatgctga     4020

tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt atggccgaga     4080

ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag ggactgagca     4140

agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc aattgcggct     4200

tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa accgccaccg     4260

gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc acctactaca     4320

acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac agactgagcg     4380

aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc gaggctctga     4440

gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg tgcctgaact     4500

gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga agctggctgt     4560

tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc aacaccgaca     4620

agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa gaagtctgga     4680

agcccgccgt gactagtcca aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg     4740

tccctgacta cgcttga                                                    4757


<210>  893
<211>  4821
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP51 plasmid sequence

<400>  893
atgggcgatc ctctgacatg gagcaaggcc ctgaagaagc tggagaaggt gaccgtgcag       60

ggcagccaga agctgaccac aggcaactgc aattgggccc tgtccctggt ggacctgttc      120

cacgatacaa actttgtgaa ggagaaggat tggcagctgc gcgacgtgat cccactgctg      180

gaggacgtga cccagacact gtctggccag gagcgggagg ccttcgagag aacctggtgg      240

gccatcagcg ccgtgaagat gggcctgcag atcaacaatg tggtggatgg caaggcctct      300

tttcagctgc tgagggccaa gtacgagaag aagacagcca acaagaagca gtctgagcct      360

agcgaggagt atccaatcat gatcgacggc gccggcaacc ggaatttcag accactgacc      420

cccagaggct acaccacatg ggtgaacaca atccagacca acggcctgct gaatgaggcc      480

tcccagaatc tgttcggcat cctgagcgtg gattgtacct ccgaggagat gaatgccttt      540

ctggacgtgg tgccaggaca ggcaggacag aagcagatcc tgctggacgc catcgataag      600

atcgccgacg attgggataa ccggcaccca ctgcccaatg cacctctggt ggcaccacct      660

cagggaccta tcccaatgac agccaggttt atcaggggac tgggagtgcc acgggagaga      720

cagatggagc ccgccttcga ccagtttagg cagacctacc gccagtggat catcgaggcc      780

atgagcgagg gcatcaaagt gatgatcggc aagccaaagg cacagaacat caggcaggga      840

gccaaggagc cctatcctga gttcgtggat agactgctgt cccagatcaa gtctgagggc      900

caccctcagg agatctccaa gtttctgacc gacacactga ccatccagaa cgccaatgag      960

gagtgccgga atgccatgcg gcacctgaga ccagaggata ccctggagga gaagatgtac     1020

gcctgtagag acatcggcac cacaaagcag aagatgatgc tgctggccaa ggccctgcag     1080

acaggcctgg ccggaccatt caagggaggc gccctgaagg gcggccccct gaaggccgcc     1140

cagacctgct ataactgtgg caagccagga cacctgagct cccagtgcag ggcaccaaag     1200

gtgtgcttca agtgtaagca gcctggccac ttttctaagc aatgcagaag tgttccaaaa     1260

aacgggaagc aaggggctca agggaggccc cagaaacaaa ctttcccgat acaacagaag     1320

agtcagcaca acaaatctgt tgtacaagag actcctcaga ctcaaaatct gtacccagat     1380

ctgagcgaaa taaaaaagga atacaatgtc aaggagaagg atcaagtaga ggatctcaac     1440

ctggacagtt tgtgggagta aacatataac ctggagaagc gccccaccac aatcgtgctg     1500

atcaacgaca cccctctgaa cgtgctgctg gacacaggag ctgatacatc tgtgctcacc     1560

accgcccact acaaccggct gaagtacaga ggcagaaagt accagggcac cggcatcatc     1620

ggcgtgggcg gaaatgtgga aaccttcagc accccagtga ccattaagaa aaagggccgg     1680

cacatcaaaa ccagaatgct ggtcgccgac atccctgtga caatcctggg cagagatatc     1740

cttcaggact taggtgcagg tgccagcgag gagtatccaa tcatgatcgg cggcagccca     1800

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1860

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1920

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1980

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     2040

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     2100

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     2160

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     2220

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     2280

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     2340

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     2400

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     2460

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2520

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2580

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2640

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2700

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2760

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2820

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2880

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2940

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     3000

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     3060

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     3120

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     3180

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     3240

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     3300

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     3360

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     3420

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3480

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3540

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3600

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3660

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3720

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3780

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3840

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3900

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3960

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     4020

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     4080

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     4140

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     4200

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     4260

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     4320

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     4380

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     4440

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4500

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4560

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4620

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4680

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4740

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4800

gatgtccctg actacgcttg a                                               4821


<210>  894
<211>  4871
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP52 plasmid sequence

<400>  894
atgggcgcca ggaacagcgt gctgtccggc aaggaggccg atgagctgga gaaggtgcgg       60

ctgagaccca atggcaagaa gaagtacatg ctgaagcacg tggtgtgggc agcaaacgag      120

ctggaccgct tcggcctggc cgagtctctg ctggataata aggagggctg ccagaagatc      180

ctgagcgtgc tggcccctct ggtgccaacc ggctctgaga acctgaagag cctgtataat      240

acagtgtgcg tgatctggtg tatccacgcc gaggagaagg tgaagcacac cgaggaggcc      300

aagcagatcg tgcagaggca cctggtggtg gagaccggca cagcagatag gatgccagcc      360

accagccgcc caacagcacc accttccgga aggggcggca actaccccgt gcagcaagtg      420

ggcggcaatt atgtgcacct gcccctgagc cctagaaccc tgaacgcctg ggtgaagctg      480

gtggaggaga agaagttcgg agcagaggtg gtgccaggat ttcaggccct gtccgagggc      540

tgcacaccct acgacatcaa ccagatgctg aattgcgtgg gagagcacca ggcagcaatg      600

cagatcatcc gggagatcat caacgaggag gcagcagact gggatctgca gcaccctcag      660

ccaggaccac tgcctgcagg acagctgcgg gagcctagag gctctgacat cgccggcacc      720

acaagcaccg tggatgagca gatccagtgg atgtacaggc agcagaaccc aatccccgtg      780

ggcaatatct atcggagatg gatccagctg ggcctgcaga agtgcgtgcg gatgtataac      840

ccaaccaata tcctggacgt gaagcagggc ccaaaggagc ccttccagag ctacgtggac      900

agattctaca agtccctgag agccgagcag acagatcccg ccgtgaagaa ctggatgacc      960

cagacactgc tgatccagaa cgccaatccc gattgcaagc tggtgctgaa gggcctgggc     1020

atgaatccta ccctggagga gatgctgaca gcatgtcagg gagtgggagg acctggacag     1080

aaggcaaggc tgatggcaga ggccctgaag gaggccctga ggcctgacca gctgccattt     1140

gccgccgtgc agcagaaggg ccagaggaag accatcaagt gctggaactg tggcaaggag     1200

ggacactctg ccaagcagtg cagggcacca aggcgccagg gatgctggaa gtgtggcaag     1260

acaggccacg tgatggccaa gtgtcctgag aggcaggcag gcttcctggg actgggacca     1320

tggggcaaga agccaagaaa ttttcctatg gcccagatgc ctcagggact gatcccaacc     1380

gcaccaccag aggacccagc agtggatctg ctgaagaact acatgaagat gggcaggaag     1440

cagcgcgaga atagggagcg cccttataag gaggtgacag aggacctgct gcacctgaac     1500

tctctctttg gagaagacca gtagttacag cctacatcga ggaacagcct gtggaagtgc     1560

tgctggatac aggagctgat gacagcatcg tggccggcat tgagctggga cctaactaca     1620

ccccaaagat cgtgggcggc atcggcggat tcatcaatac caaagagtac aaggacgtga     1680

agatcaaagt gctgggcaag gtgatcaagg gcaccatcat gaccggcgac acacccatca     1740

acatcttcgg cagaaacctg ctcaccgcca tgggcatgtc tctgaacctg cctatcgcca     1800

aggtcgaggg tgccggcggc aactaccccg tgcagcaagg cggcagccca aagaagaagc     1860

ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg     1920

acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga     1980

tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc     2040

agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga     2100

tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga     2160

tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga     2220

tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc     2280

tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg     2340

gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga     2400

aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact     2460

tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg     2520

ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa     2580

caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca     2640

agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat     2700

accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg     2760

aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt     2820

ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg     2880

aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca     2940

acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag     3000

aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca     3060

gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca     3120

aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca     3180

ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt     3240

ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt     3300

tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg     3360

ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg     3420

ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact     3480

tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat     3540

tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact     3600

tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt     3660

tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag     3720

tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg     3780

ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga     3840

tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat     3900

gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg     3960

agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag     4020

ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc     4080

gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg     4140

agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt     4200

acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct     4260

acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca     4320

tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga     4380

tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt     4440

acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga     4500

gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc     4560

tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct     4620

tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga     4680

gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg     4740

cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg     4800

ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg     4860

actacgcttg a                                                          4871


<210>  895
<211>  4700
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP53 plasmid sequence

<400>  895
atggccaagc agggctccaa ggagaagaag ggctaccccg agctgaagga agtgatcaag       60

gcaacctgca agatcagggt gggacctggc aaggagaccc tgacagaggg caactgtctg      120

tgggccctga agacaatcga cttcatcttt gaggatctga agaccgagcc atggaccatc      180

acaaagatgt atacagtgtg ggatcggctg aagggactga ccccagagga gacatccaag      240

agagagttcg cctctctgca ggccaccctg gcctgcatca tgtgctccca gatgggcatg      300

aagcctgaga cagtgcaggc cgccaagggc atcatctcta tgaaggaggg cctgcacgag      360

aataaggagg ccaagggcga gaaggtggag cagctgtacc ctaacctgga gaagcacagg      420

gaggtgtatc caatcgtgaa tctgcaggca ggaggccgca gctggaaggc agtggagtcc      480

gtggtgttcc agcagctgca gaccgtggcc atgcagcacg gcctggtgtc tgaggacttt      540

gagcggcagc tggcctacta tgccaccaca tggacaagca aggatatcct ggaggtgctg      600

gccatgatgc caggcaacag agcccagaag gagctgatcc agggcaagct gaatgaggag      660

gcagagcggt gggtgagaca gaacccacct ggacccaatg tgctgaccgt ggaccagatc      720

atgggcgtgg gccagacaaa ccagcaggcc agccaggcca atatggatca ggccaggcag      780

atctgcctgc agtgggtcat caccgccctg aggagcgtgc gccacatgtc ccacaggcct      840

ggaaacccaa tgctggtgaa gcagaagaat acagagtcct acgaggactt catcgccagg      900

ctgctggagg caatcgacgc agagcccgtg acagatccta tcaagaccta cctgaaggtg      960

accctgtctt atacaaacgc cagcaccgac tgccagaagc agatggatag gaccctggga     1020

acacgcgtgc agcaggcaac cgtggaggag aagatgcagg cctgtcggga tgtgggctct     1080

gagggcttta agatgcagct gctggcccag gccctgagac ctcagggcaa ggcaggacag     1140

aagggagtga accagaagtg ctacaattgt ggcaagccag gacacctggc aaggcagtgc     1200

agacagggaa tcatctgcca ccactgtggc aagaggggcc acatgcagaa ggactgtcgc     1260

cagaagaagc agcagggcaa caataggaga ggaccaaggg tggtgccatc tgccccacca     1320

atgctgtgac agaggcccct cctaagatcg agatcaaggt gggcacaaga tggaagaaac     1380

tgctggtcga caccggcgct gataagacca tcgtgaccag ccacgacatg agcggcatcc     1440

ccaagggcag aatcatcctg cagggcattg gaggaatcat cgagggcgag aagtgggagc     1500

aggtgcacct gcagtacaag gacaagatca tccggggcac catcgtggtg ctcgccacat     1560

ctccagtgga agtgctggga agagataaca tgcgggaact gggcatcggc ctgatcatgg     1620

ctaacctgga agagaaaggt gccagggagg tgtatccaat cgtgaatggc ggcagcccaa     1680

agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc agaaggagac     1740

tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa accctgctcg     1800

tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag aagcccgaga     1860

acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg ctgaccgact     1920

acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag aaagaccccg     1980

tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag aacaagctga     2040

agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg     2100

gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag gcctacacca     2160

actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg gcccagctga     2220

aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt ggacagagag     2280

ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg aagcccctgg     2340

ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg tccgatgcct     2400

gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc gagcaccaga     2460

aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc ggcaaagaga     2520

acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa ggcgtggacg     2580

cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc     2640

tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc cctagcttcc     2700

ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc aacgtgaaga     2760

agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg gccggctaca     2820

agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag aagggcaaga     2880

agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg     2940

actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg gaaggcctga     3000

gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct aaagccgctc     3060

tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa gaggccgaca     3120

aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat ctgagaggca     3180

agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc agcaagcagt     3240

acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg tacctgatca     3300

tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag gccttcgagg     3360

ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc atggaagtga     3420

acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc aagagacagg     3480

gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg aagctggcca     3540

atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac gagcctgctc     3600

tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac atcaagccca     3660

tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc ctgacagacc     3720

ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca cacatcctga     3780

gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa gaggtggaac     3840

agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat ctggccgacg     3900

acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag gacgccatgc     3960

tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc tttatggccg     4020

agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac gagggactga     4080

gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc agcaattgcg     4140

gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag aaaaccgcca     4200

ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag atcacctact     4260

acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg gacagactga     4320

gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca ggcgaggctc     4380

tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc gtgtgcctga     4440

actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc agaagctggc     4500

tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc ggcaacaccg     4560

acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg aaagaagtct     4620

ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt agccctcgag tacccatatg     4680

atgtccctga ctacgcttga                                                 4700


<210>  896
<211>  5479
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP54 plasmid sequence

<400>  896
agccattgcc ttttatggta atcgtgcgag agggcgcagg gacttccttt gtcccaaatc       60

tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct ctagcgggcg cggggcgaag      120

cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc      180

cgtccccttc tccctctcca gcctcggggc tgtccgcggg gggacggctg ccttcggggg      240

ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag agcctctgct      300

aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttattgtg      360

ctgtctcatc attttggcaa agaattcgcc accatggccc tgaatgattt cgaccctatc      420

gccctccagg gctacctgcc ggcccctaga gtgctgcaac acaacgacat catcatctgc      480

agagctactt ctggcccctg gggcatcggc gacagataca acctgatcag gatccacctg      540

caagaccctg ccggacagcc ccttccaatc ccccagtggg agcctatccc taaccggacc      600

gccaaccccc ggacacagcc ctaccctgtg gtgtctgccc caatggctac cctggaaaac      660

atcctgaaca actttcacat cccccacggc gtgtccagat acggccccct ggaaggcgga      720

gattaccagc ctggcgaaca gtacagccaa ggcttctgcc ctgtgaccca ggccgagatt      780

gccctgctga acggccagca cctggaagaa gagatcacaa tcctgagaga gatcacccac      840

agactgatgc agggcgtgcg gcctcctgcc gtgcctcagg gccctgctcc tcctcctcct      900

ccagctcagc ctcctgctcc cctgcctgct ccaccaattg ggcctccacc tcccgctgcc      960

cctgcccccg ccccaggccc catgcctgtg ccccagcatc tgcctattac acatatcaga     1020

gccgtgatcg gcgaaacccc cgccaacatc cgcgaggtgc cactgtggct ggctagagcc     1080

gttcccgccc tgcagggagt gtaccccgtc caggacgccg tgatgagaag ccgcaccgtg     1140

aacgccctga ccgtgcggca ccctggactg gccctggaac ctctggagtg cggcagctgg     1200

caagagtgtc tggccgccct gtggcagaga accttcggcg ccaccgccct gcacgccctg     1260

ggcgataccc tgggtcagat cgcaaacagc gacggcatcg tgatggctat cgagctgggc     1320

ctgctctttt ccgatgataa ctgggacctg gtgtggggaa tctgtagaag attcctgccc     1380

ggccaggccg tctgcgtggc cgtgcaggcc agactggatc ccctgcccga caacgctaca     1440

agaatcgtga tgatcagcca catcatccgg gacgtgtacg ccatcctggg cctggaccct     1500

ctgggcagac ccatgcagca gacactgcct agacggaaca accagcctcc cagacagcag     1560

ccacagagac ggcagcagcc tagaagaacc ggcaaccagg aggaaagagg ccagcggaac     1620

cggggccggc agaacgccca gacccctcgg caggagggca acagactgca gaacagccag     1680

ctgcctggcc ctcgcgactg ccccaacaat agcaaccagc ctcggtaccc tctgcggcca     1740

aacccccagc agccccaaag atacggccag gagcagaatc gtggcaacaa tcccaaccct     1800

tacagacaac ctacccctgg caatggaaat caaaacagaa acttcagccg ggggcctgcc     1860

ccagtcaatg agcagagcag aggcagagga agatctagcc agggtacaaa taacaccggc     1920

tcctctgctg tgcacagcgt gcggctgacc agcgccgccc ctcctatacc cccacaagat     1980

gccggcactc cgcccacttc aagtggaaat caagggcaat catcttaaag gctactggga     2040

cagcggcgcc gagatcacat gcgtgcccgc tatctacatc atcgaggaac aacctgttgg     2100

caagaagctg attacaacca tccacaacga gaaggaacat gatgtgtact acgtggaaat     2160

gaaaatcgag aagcggaagg tgcagtgtga agtgatcgcc accgccctgg attacgtgct     2220

ggtggcccct gtggacatcc cctggtataa gcctggacct ctggaactga ccatcaagat     2280

cgacgtcgag agccagaagc acaccctgat cacagagtcc accctctctc cacagggcca     2340

gatgagactg aagaaactgc tggaccagta ccaggccctg tggcagtgct gggagaacca     2400

ggtgggccac agaagaggtg cctctgctgt gcacagcgtg cggctgggcg gcagcccaaa     2460

gaagaagcgg aaggtctcta gacaagagat caagagaatc aacaagatca gaaggagact     2520

ggtcaaggac agcaacacaa agaaggccgg caagacaggc cccatgaaaa ccctgctcgt     2580

cagagtgatg acccctgacc tgagagagcg gctggaaaac ctgagaaaga agcccgagaa     2640

catccctcag cctatcagca acaccagcag ggccaacctg aacaagctgc tgaccgacta     2700

caccgagatg aagaaagcca tcctgcacgt gtactgggaa gagttccaga aagaccccgt     2760

gggcctgatg agcagagttg ctcagcctgc cagcaagaag atcgaccaga acaagctgaa     2820

gcccgagatg gacgagaagg gcaatctgac cacagccggc tttgcctgct ctcagtgtgg     2880

ccagcctctg ttcgtgtaca agctggaaca ggtgtccgag aaaggcaagg cctacaccaa     2940

ctacttcggc agatgtaacg tggccgagca cgagaagctg attctgctgg cccagctgaa     3000

acctgagaag gactctgatg aggccgtgac ctacagcctg ggcaagtttg gacagagagc     3060

cctggacttc tacagcatcc acgtgaccaa agaaagcaca caccccgtga agcccctggc     3120

tcagatcgcc ggcaatagat acgcctctgg acctgtgggc aaagccctgt ccgatgcctg     3180

catgggaaca atcgccagct tcctgagcaa gtaccaggac atcatcatcg agcaccagaa     3240

ggtggtcaag ggcaaccaga agagactgga aagcctgagg gagctggccg gcaaagagaa     3300

cctggaatac cccagcgtga ccctgcctcc tcagcctcac acaaaagaag gcgtggacgc     3360

ctacaacgaa gtgatcgcca gagtgagaat gtgggtcaac ctgaacctgt ggcagaagct     3420

gaaactgtcc agggacgacg ccaagcctct gctgagactg aagggcttcc ctagcttccc     3480

tctggtggaa agacaggcca atgaagtgga ttggtgggac atggtctgca acgtgaagaa     3540

gctgatcaac gagaagaaag aggatggcaa ggttttctgg cagaacctgg ccggctacaa     3600

gagacaagaa gccctgaggc cttacctgag cagcgaagag gaccggaaga agggcaagaa     3660

gttcgccaga taccagctgg gcgacctgct gctgcacctg gaaaagaagc acggcgagga     3720

ctggggcaaa gtgtacgatg aggcctggga gagaatcgac aagaaggtgg aaggcctgag     3780

caagcacatt aagctggaag aggaaagaag gagcgaggac gcccaatcta aagccgctct     3840

gaccgattgg ctgagagcca aggccagctt tgtgatcgag ggcctgaaag aggccgacaa     3900

ggacgagttc tgcagatgcg agctgaagct gcagaagtgg tacggcgatc tgagaggcaa     3960

gcccttcgcc attgaggccg agaacagcat cctggacatc agcggcttca gcaagcagta     4020

caactgcgcc ttcatttggc agaaagacgg cgtcaagaaa ctgaacctgt acctgatcat     4080

caattacttc aaaggcggca agctgcggtt caagaagatc aaacccgagg ccttcgaggc     4140

taacagattc tacaccgtga tcaacaaaaa gtccggcgag atcgtgccca tggaagtgaa     4200

cttcaacttc gacgacccca acctgattat cctgcctctg gccttcggca agagacaggg     4260

cagagagttc atctggaacg atctgctgag cctggaaacc ggctctctga agctggccaa     4320

tggcagagtg atcgagaaaa ccctgtacaa caggagaacc agacaggacg agcctgctct     4380

gtttgtggcc ctgaccttcg agagaagaga ggtgctggac agcagcaaca tcaagcccat     4440

gaacctgatc ggcgtggacc ggggcgagaa tatccctgct gtgatcgccc tgacagaccc     4500

tgaaggatgc ccactgagca gattcaagga ctccctgggc aaccctacac acatcctgag     4560

aatcggcgag agctacaaag agaagcagag gacaatccag gccaagaaag aggtggaaca     4620

gagaagagcc ggcggatact ctaggaagta cgccagcaag gccaagaatc tggccgacga     4680

catggtccga aacaccgcca gagatctgct gtactacgcc gtgacacagg acgccatgct     4740

gatcttcgag aatctgagca gaggcttcgg ccggcagggc aagagaacct ttatggccga     4800

gaggcagtac accagaatgg aagattggct cacagctaaa ctggcctacg agggactgag     4860

caagacctac ctgtccaaaa cactggccca gtatacctcc aagacctgca gcaattgcgg     4920

cttcaccatc accagcgccg actacgacag agtgctggaa aagctcaaga aaaccgccac     4980

cggctggatg accaccatca acggcaaaga gctgaaggtt gagggccaga tcacctacta     5040

caacaggtac aagaggcaga acgtcgtgaa ggatctgagc gtggaactgg acagactgag     5100

cgaagagagc gtgaacaacg acatcagcag ctggacaaag ggcagatcag gcgaggctct     5160

gagcctgctg aagaagaggt ttagccacag acctgtgcaa gagaagttcg tgtgcctgaa     5220

ctgcggcttc gagacacacg ccgatgaaca ggctgccctg aacattgcca gaagctggct     5280

gttcctgaga agccaagagt acaagaagta ccagaccaac aagaccaccg gcaacaccga     5340

caagagggcc tttgtggaaa cctggcagag cttctacaga aaaaagctga aagaagtctg     5400

gaagcccgcc gtgactagtc caaaaaagaa gagaaaggta gccctcgagt acccatatga     5460

tgtccctgac tacgcttga                                                  5479


<210>  897
<211>  5764
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP55 plasmid sequence

<400>  897
agccattgcc ttttatggta atcgtgcgag agggcgcagg gacttccttt gtcccaaatc       60

tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct ctagcgggcg cggggcgaag      120

cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc      180

cgtccccttc tccctctcca gcctcggggc tgtccgcggg gggacggctg ccttcggggg      240

ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag agcctctgct      300

aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttattgtg      360

ctgtctcatc attttggcaa agaattcgcc accatgagcc agccctccgc ttctggcagc      420

gccggcgccg gaggcgcccc tcagcaacct cctcctccac ctccccagcc cggacctgcc      480

gcccccgtgc ctagagccca gatcggttat ggagatctgg acgtgcttct gctgcaacag      540

gagtaccacc tcatcgatcc taatctgcaa gtgcaacacc tggacaccct gctggtgaga      600

atcacaggcg gaaactgggg ccctggcgat agattcgcca gaatcgaggt gctgctccgc      660

gacacactgg gccctctgca acagcctaga tacagatacg ccgccatgca gcaggccgac      720

ctgagaaacg acatcatcct gcacctgaac taccaggatg ccatcatcat cttcgacatg      780

atcatcccca gcgagggcgt gcaccggcac ggccctatgt ttgacggcct gtggatccac      840

ggcgacgact acagcatgaa cttccagcct atcacagccc acgagctgta cctgctgcct      900

cagcaggtgc tgaccgagga agtggaactg ctcaccgagg tgtgcaacag aatggccgat      960

tggatccggc ggcacaggtg tggcggagga agcggctcct ctcagccacc tcctccccca     1020

cctccagccg tgccagtgct gcctagtgcc cctccagcca gcagcctgcc cctgccccca     1080

cagggctggg gcatctctcc tcccgtggct accagcaccc ctggcgctgc cggacattct     1140

agcagcgccg gtcctaacat cagcctgggc ggcacctacg tgccccctcc tgtggctcct     1200

ccagcccctg tgatcggcgg ccctggcgga cccggacagc tgcctgctat ggtgcaggtg     1260

ctgcccgctc aacctgtcgt gatccccatt aacgtgatca gatctgtgtg cggcgataca     1320

cctagcaacc ctcaagacat ccctctgtgg atgggcagaa tcatccccgc cattgagggc     1380

gtctttccta ttgacaaccc caatctgaga atgagagtgg tgaacgccct gctggctctg     1440

catcctggcc tggctatcac cgaactgaat gcccagacat ggggccaggt tctggctgtg     1500

ctgcacatgc gggccctggg acacaccgcc ctgcaccagc tgcctgccct gctggaaaca     1560

atcgtgaaga ccgacggcat cctgccagct tataacatgg gcatggaagt tacacagcag     1620

gatttcagct acgtgtgggg catcctgcgg acactgttgc ccggccaagc cttcgtgctg     1680

agcatgcaga acgagctgga ccggctgcct gccgcccaga gacctggaat gttccccggc     1740

ctgctgcaga gaaccctgga tatcctgggc ctgaacagca gaggacagaa catccagaaa     1800

accaacaccc agcagcaggc cccaaagcgg ggccagaagc ctaagcccag actgccccca     1860

gtgcacagac ggcctgcacc cttcacccct cctgccaccc ccagccctcg gcagcaggcc     1920

agcgccagcc ccagcagcca gggcgacaac agaagccctc agcctcaggg cagaggcaca     1980

tacggcccga gccggggagg cggctctggc cctagataca acttccgtcc cagagtgcag     2040

cctcccgaca gatacggctt cggcagaggc cagggaggca gaagcagcat cggcgcccag     2100

gacaatcagc agcccggaca aggcggacag cggacccagc agaccaacca gaaccgcaac     2160

cagggcaacg ccaccggcgg tagaacccag cctcagaata gaacagtgaa caccgtgcgg     2220

gtgacccaga ccaatcctca aggcggctcc tccgtgtcca acccagctgt gacaacttct     2280

cagaatacag gaacaggaag tgcaactcag agctcatcat cttaaaggct ttgtggacac     2340

aggcagcagc atcacctgct tccccaagta caccctggtc gaggaagatc ctatcggcca     2400

gtacgacatc agcaccatcc acggcacagt gtcccagcct gtgtactaca tcaagttcaa     2460

ggtgaacggc aagaaagtgg aagccgaggt gaccgagtct ccactggact acgtgatcct     2520

gtgtcctagc gacgtgccct ggctgtctac aaagctggaa ctgacaatta agctgcctct     2580

gcaccagcag caacaggagc tgctgagcaa gaccagagtg aatcaaaaac agctgcagaa     2640

actctttatc cagtatgatg acctgtggca gaagtgggag aaccaggttg gacaccggaa     2700

gggtgccaga acagtgaaca ccgtgcgggt gggcggcagc ccaaagaaga agcggaaggt     2760

ctctagacaa gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa     2820

cacaaagaag gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc     2880

tgacctgaga gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat     2940

cagcaacacc agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa     3000

agccatcctg cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag     3060

agttgctcag cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga     3120

gaagggcaat ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt     3180

gtacaagctg gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg     3240

taacgtggcc gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc     3300

tgatgaggcc gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag     3360

catccacgtg accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa     3420

tagatacgcc tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc     3480

cagcttcctg agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa     3540

ccagaagaga ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag     3600

cgtgaccctg cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat     3660

cgccagagtg agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga     3720

cgacgccaag cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca     3780

ggccaatgaa gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa     3840

gaaagaggat ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct     3900

gaggccttac ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca     3960

gctgggcgac ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta     4020

cgatgaggcc tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct     4080

ggaagaggaa agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag     4140

agccaaggcc agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag     4200

atgcgagctg aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga     4260

ggccgagaac agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat     4320

ttggcagaaa gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg     4380

cggcaagctg cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac     4440

cgtgatcaac aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga     4500

ccccaacctg attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg     4560

gaacgatctg ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga     4620

gaaaaccctg tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac     4680

cttcgagaga agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt     4740

ggaccggggc gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact     4800

gagcagattc aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta     4860

caaagagaag cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg     4920

atactctagg aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac     4980

cgccagagat ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct     5040

gagcagaggc ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag     5100

aatggaagat tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc     5160

caaaacactg gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag     5220

cgccgactac gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac     5280

catcaacggc aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag     5340

gcagaacgtc gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa     5400

caacgacatc agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa     5460

gaggtttagc cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac     5520

acacgccgat gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca     5580

agagtacaag aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt     5640

ggaaacctgg cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac     5700

tagtccaaaa aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc     5760

ttga                                                                  5764


<210>  898
<211>  5404
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP56 plasmid Sequence

<400>  898
atggcctctg gcagcaacgt ggaggaatac gagctggatg tggaagccct ggtggtcatc       60

ctgcgggaca gaaacatcgg aagaaatccc ctgcacggcg aaatcatcgg cctgagactg      120

accgagggct ggtggggcca gatcgagaga tttcagatgg tgcggctgat cctgcaggac      180

gacgacaacg agcccctgca gagaccccgc tacgaggtga tccccagagc cgtgaacccc      240

cacaccatgt tcatgatcag cggccccctg gctgaactgc agctggcctt ccaggacctg      300

gacctgcccg agggccctct gcggtttggc ccgctggcta acggccacta cgtgcagggg      360

gatccttaca gcagcagcta ccggcccgtg accatggccg aaacagccca gatgaccaga      420

gatgagctgg aagatatcct gaacacccaa agcgagatcg agatccagat gatcaacctg      480

ctggaacttt atgaggtgga aaccagagcc ctgagaagac agctggccga gagaagcagc      540

atcggccagg gaggagtgag ccccggcgct ccaaggccga gacctccagt tagcagcttc      600

agcggcctgc ctagcctgcc ttctatcccc ggcatccacc ccagagcccc ttcccctcct      660

cgcgctacaa gcacccctgg taacatcccc tggtccctgg gagatgacag cccacctagc      720

tcgtcttttc ctggccctag tcagcctaga gtgtctttcc accctggcaa tcctttcgtg      780

gaggacgagg gacatagacc tagatcccag agccgggaaa gacggagaaa caatcctcct      840

gcccctatcc ctagcgcccc tccaatgatc caatacgtgc ccgtgcctcc tccacctcct      900

gtcggaaccg tgatacctat ccaacacatc cggtccgtga ccggcgagcc tccaaagaac      960

ccccgagaaa tccccatctg gctgggccgg aatgcccctg ctatcgacgg cgttttcccc     1020

gtgacgaccc cagacctgcg gtgcagaatc atcaacgcca ttctgggagg caacctgggc     1080

ctgagcctga cacctgccga ctgtgtgacc tgggactctg ccgtgggcac cctgttcgtg     1140

cggacacacg gacagttccc tatgcaccag ctgggcacag tgatccaggg catcgtgaac     1200

caggagggcg tggctaccgc ttatacactg ggcatgatgc tgagcggcca gaattacccc     1260

ctcgtgagcg gcatcatcag aggctacctg cccggccagg ccgtggtgac cgcccttcag     1320

cagcgcctgg accaggaggt ggatgaccag gccagggctg aaaccttcat ccagcacctg     1380

aacgctgtgt acgagatcct gggcctcaac gccagaggac aatctatcag agccagcgtg     1440

acaccgcaac ctcggccaag ccggggccgc ggcagaggcc agtctacacc tagaccttcc     1500

cagggccctg tgagttcagg acggggcaga cagcggcctg ccagcggcca gtacgacaga     1560

ggcagcaaca accagaacca agaccagggt aacaccagcc agggcggcta caacctgaga     1620

ccaagaacct accagcctca gagatacggc ggcggaagag gtcggagatg gaacgagaac     1680

accaacagcc aggagagcag acccagcgat cagggctccc agacaccccg gcctaaccaa     1740

gctggcagcg gcgtcagagg caaccagagc cagaccccta gacccgccgc cggcagagga     1800

ggcagaggca atcagaatag aaaccagcgg tctagcggag ccggcgatag cagagccgtc     1860

aacacagtga cccagagtgc cacgtcctcc acagatgaat cctcttcagc tgttgcaacc     1920

gcttccagcg gagatcaaag gaactaaact gttagcccat tgggacagcg gcgccaccat     1980

tacatgcgtg cccgagtcct tcctggaaga tgagcagcct atcaaacaga ccctgatcaa     2040

gacaatccac ggcgagaagc agcagaaagt gtactacctg acctttaaga tcaagggaag     2100

aaaggtggaa gctgaagtga tcgccagccc ttacgagtac atcctgctgt ctccaacaga     2160

cgtgccttgg ctgacacagc aacctctgca gctgaccatc ctggtccccc tgcaggagta     2220

tcaggataga atcctcaaca agaccgccct gcctgaggaa cagaagcaaa gactgaagac     2280

cctgttcgcc aagtacgaca ccctgtggca gcactgggag aaccaggtgg gccaccggcg     2340

gggtgccaga gccgtcaaca cagtgaccca gggcggcagc ccaaagaaga agcggaaggt     2400

ctctagacaa gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa     2460

cacaaagaag gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc     2520

tgacctgaga gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat     2580

cagcaacacc agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa     2640

agccatcctg cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag     2700

agttgctcag cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga     2760

gaagggcaat ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt     2820

gtacaagctg gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg     2880

taacgtggcc gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc     2940

tgatgaggcc gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag     3000

catccacgtg accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa     3060

tagatacgcc tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc     3120

cagcttcctg agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa     3180

ccagaagaga ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag     3240

cgtgaccctg cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat     3300

cgccagagtg agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga     3360

cgacgccaag cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca     3420

ggccaatgaa gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa     3480

gaaagaggat ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct     3540

gaggccttac ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca     3600

gctgggcgac ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta     3660

cgatgaggcc tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct     3720

ggaagaggaa agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag     3780

agccaaggcc agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag     3840

atgcgagctg aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga     3900

ggccgagaac agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat     3960

ttggcagaaa gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg     4020

cggcaagctg cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac     4080

cgtgatcaac aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga     4140

ccccaacctg attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg     4200

gaacgatctg ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga     4260

gaaaaccctg tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac     4320

cttcgagaga agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt     4380

ggaccggggc gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact     4440

gagcagattc aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta     4500

caaagagaag cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg     4560

atactctagg aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac     4620

cgccagagat ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct     4680

gagcagaggc ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag     4740

aatggaagat tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc     4800

caaaacactg gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag     4860

cgccgactac gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac     4920

catcaacggc aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag     4980

gcagaacgtc gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa     5040

caacgacatc agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa     5100

gaggtttagc cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac     5160

acacgccgat gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca     5220

agagtacaag aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt     5280

ggaaacctgg cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac     5340

tagtccaaaa aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc     5400

ttga                                                                  5404


<210>  899
<211>  5140
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP57 plasmid sequence

<400>  899
atggcccaga acgagacatt tgatcctgtg gccctgcagg gctactaccc tgctggcggc       60

atcctggccg acaatgacat tatcaacatc agattcacca gcggacagtg gggcatcggc      120

gatagatggc tgcaggtgcg gctgagactg gtggacccta atactggaca gcctctggct      180

cagcctgagt acgaggacac aggcctgcct gccgaaaaca ggggtatcgt ggtggccgtg      240

tcccacaacg ccgccagaaa tatcttcaac aacgtgcagc cagctggtgg ccccaacaga      300

cacggccctc tgcacgacgg ccaatttcaa gtgggcgacg atcccagcga gcacttcgtg      360

cctattgagg aaaacctgat cccccaggag atcgtgaacc tgggagcagc tagaagagaa      420

gtgcggctgc tgagagaaat gtgcgtgcgg ctgctgcacg tgagaagaca gatgatgggc      480

atgggcatgc ctggcgctat ccagcctcaa ccgccagtgg gccccctgcc cgcccctgcc      540

cagcccccta tccctggccc acctgtgcct ccccccgtgc ctccccccgc ccctccagcc      600

cctgtcaacc cccctgtccc tccagtgcag cctatccacc acctgcctat tacccacatc      660

cgggccgtga tcggcgagac acctgcccag atcagagatg tgcccctgtg gctggcccag      720

tccatccctg ccctgaccgg cgtttatcct gccatggacg ccggaacact gacaagactg      780

gtgaacgcga tcaccgccag acaccccgga ctcgctcttg gcatgaacga ggccggctcc      840

tggcacgagg ccgttcatct gatctggcag aggaccttcg gcgctacagc cctccatgcc      900

ttgtctgatg tgctgaaggg catcgcccag cggaacggcg tggtgatggc cctggaaatg      960

ggcctgatgt tcaccaacga cgactgggac ctgacctggt ctgtgatccg gagatgtctg     1020

cctggacaag ccagcgttgt gaccatccag gcccggctgg atgccctgcc aaacaaccag     1080

gccaggatca tccaggccgg ctttatcatc agagaggtgt acgaggtgct gggcctggac     1140

ccactgggcc ggccactgaa cttccctgga ggcctgaccc agcgagacac cgccgtgccc     1200

gtgaccagag gccggggccg cggaagaacc ggccctagaa gaggccctgt gctgcctgtc     1260

agcagcaacc agcgccggca agaaaccgca ggcggcaacc agcctcagac ccaaccccag     1320

cagcagaaca cattcagcaa tcagacaaat cagagaggaa accagcggca gtggcaaaat     1380

agaggaaccg acagccagag acggtacttc ttcagaccca gaccaagcca gcctcagcgg     1440

tacggcagca accagggccc tgacaaccct aatccctaca gaggaagaga tagcaccaat     1500

caaagcggcc aggagcggca gctgcctcag cagcaacagg gctctagaag gggccctggc     1560

agaaacacaa acagcggcaa caacaccgtg cacaccgtgc ggcaagtgga atcttctcag     1620

ctacaacaaa atgcaagccc tacagcctct ccaagtacaa atcaagggca acagccttaa     1680

gggattttat gataccggcg ccgagatcac ctgcgtgcca gccatcttcc tgatcgagga     1740

agagcctatc ggcgagcgga ccatccaaac aatccacggc atcacaaagg aaaaggtgta     1800

ctacctgacc tttaagatcc agggcagaaa gctggccgct gaagtgattg gaacccagct     1860

ggactacgtg atcatcgccc ctagcgacat cccctggtac aagaaatacg agctggaact     1920

gacaattaaa atcgacatcc agaaacagca ggagcagctg ctgcacacca ccaacctctc     1980

tagcgaggga aagaagtacc tgaaggacct gttcatcaag tatgataatc tgtggcagaa     2040

gtgggaaaac caggtcggcc acagaagagg tgccaacacc gtgcacaccg tgcggcaagt     2100

ggaatctggc ggcagcccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat     2160

caacaagatc agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg     2220

ccccatgaaa accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa     2280

cctgagaaag aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct     2340

gaacaagctg ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga     2400

agagttccag aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa     2460

gatcgaccag aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg     2520

ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga     2580

gaaaggcaag gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct     2640

gattctgctg gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct     2700

gggcaagttt ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac     2760

acaccccgtg aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg     2820

caaagccctg tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga     2880

catcatcatc gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag     2940

ggagctggcc ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca     3000

cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa     3060

cctgaacctg tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact     3120

gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga     3180

catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg     3240

gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga     3300

ggaccggaag aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct     3360

ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga     3420

caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga     3480

cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga     3540

gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg     3600

gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat     3660

cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa     3720

actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat     3780

caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga     3840

gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct     3900

ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac     3960

cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac     4020

cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga     4080

cagcagcaac atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc     4140

tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg     4200

caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca     4260

ggccaagaaa gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa     4320

ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc     4380

cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg     4440

caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa     4500

actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc     4560

caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga     4620

aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt     4680

tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag     4740

cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa     4800

gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca     4860

agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct     4920

gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa     4980

caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag     5040

aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt     5100

agccctcgag tacccatatg atgtccctga ctacgcttga                           5140


<210>  900
<211>  4996
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP58 plasmid sequence

<400>  900
atggcccggg aactgaaccc cctgcagctg caacagctgt acatcaacaa tggcctgcag       60

cccaatcccg gccacggaga tatcatcgca gttagattca caggcggccc ttggggcccc      120

ggagatagat gggccagagt gaccatccgg ctgcaggaca acaccggcca gcctctgcaa      180

gtgcccggat acgacctgga gcctggcatc atcaatctgc gggaagatat cctgatcgcc      240

ggcccataca acctcatcag aacagctttt ctggacctgg aacctgccag aggaccagag      300

cggcacggcc cgttcggcga cggcagactg cagcctggcg atggactgag cgagggattt      360

cagcctatca ccgacgagga aatccaggct gaagtgggca ccatcggcgc cgcccgtaac      420

gagatccggc tgctgagaga agccttgcag agactccagg ctggcggtgt tggacggcct      480

atccctgggg ccgtgctgca gcctcaacct gtgatcggac ctgtgatccc catcaaccac      540

ctgagaagcg tgattggcaa cacacctcct aaccccagag atgtggccct gtggttgggc      600

agatctacag ccgctatcga gggcgtgttc cccatcgtgg accaggtgac ccggatgaga      660

gtggtgaacg ccctggtcgc ctctcatcct ggcctgaccc tgacagagaa cgaggccggc      720

agctggaacg ccgccatcag cgccctgtgg cggaaggccc acggcgctgc tgctcagcac      780

gagctggccg gagtgctgag cgacatcaac aagaaggaag gcatccagac agccttcaac      840

ctgggcatgc agttcaccga tggcaattgg tccctggtgt ggggaatcat caggaccctg      900

ctgcccggcc aggccctggt cacaaacgcc cagagccagt tcgacctgat gggcgacgac      960

attcagcggg ccgagaactt ccccagagtg attaacaacc tgtacaccat gctgggcctg     1020

aacatccacg gccagagcat cagacctaga gtgcagaccc agcctctgca gaccagacct     1080

cggaaccctg gcagaagcca gcagggtcag ctgaatcagc ctcggcctca gaacagagcc     1140

aaccagtcct acagaccccc tcggcagcag caacaacaca gcgacgtgcc tgagcagagg     1200

gaccagagag gcccatctca accgcctaga ggctctggcg gaggctataa cttcagaaga     1260

aatccccagc agcctcagcg gtacggccaa ggcccccccg gcccaaaccc ttacagacgg     1320

ttcggcgacg gcggcaatcc ccagcagcaa ggcccgcctc caaatagagg ccctgatcag     1380

ggacctagac caggcggcaa ccctcgcggc ggcggcaggg ggcagggccc ccggaacggc     1440

ggaggcagcg ccgccgccgt gcacaccgtg aaagccagcg aaaacgaaac taaaaatgga     1500

tctgctgaag ccgttgacgg tggaaagaaa gggggtaaag attaaaggtt actgggattc     1560

tcaggccgac atcacctgcg tgccaaagga cctgctgcag ggcgaggaac ccgtgcggca     1620

gcagaatgtg accaccatcc acggcaccca ggagggcgat gtctactacg tgaacctgaa     1680

gatcgacggc agaagaatca acaccgaggt gatcggcaca acactggact atgctatcat     1740

cacccctggc gacgtgcctt ggatcctgaa gaaacctctg gaactgacaa ttaagctgga     1800

tctggaagag caacaaggaa ccctgctcaa caacagcatc ctgagcaaga agggcaagga     1860

agagctgaaa cagctgttcg agaagtactc cgccctgtgg cagagctggg agaaccaggt     1920

gggacacaga cggggtgccg ccgccgtgca caccgtgaaa gccggcggca gcccaaagaa     1980

gaagcggaag gtctctagac aagagatcaa gagaatcaac aagatcagaa ggagactggt     2040

caaggacagc aacacaaaga aggccggcaa gacaggcccc atgaaaaccc tgctcgtcag     2100

agtgatgacc cctgacctga gagagcggct ggaaaacctg agaaagaagc ccgagaacat     2160

ccctcagcct atcagcaaca ccagcagggc caacctgaac aagctgctga ccgactacac     2220

cgagatgaag aaagccatcc tgcacgtgta ctgggaagag ttccagaaag accccgtggg     2280

cctgatgagc agagttgctc agcctgccag caagaagatc gaccagaaca agctgaagcc     2340

cgagatggac gagaagggca atctgaccac agccggcttt gcctgctctc agtgtggcca     2400

gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa ggcaaggcct acaccaacta     2460

cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt ctgctggccc agctgaaacc     2520

tgagaaggac tctgatgagg ccgtgaccta cagcctgggc aagtttggac agagagccct     2580

ggacttctac agcatccacg tgaccaaaga aagcacacac cccgtgaagc ccctggctca     2640

gatcgccggc aatagatacg cctctggacc tgtgggcaaa gccctgtccg atgcctgcat     2700

gggaacaatc gccagcttcc tgagcaagta ccaggacatc atcatcgagc accagaaggt     2760

ggtcaagggc aaccagaaga gactggaaag cctgagggag ctggccggca aagagaacct     2820

ggaatacccc agcgtgaccc tgcctcctca gcctcacaca aaagaaggcg tggacgccta     2880

caacgaagtg atcgccagag tgagaatgtg ggtcaacctg aacctgtggc agaagctgaa     2940

actgtccagg gacgacgcca agcctctgct gagactgaag ggcttcccta gcttccctct     3000

ggtggaaaga caggccaatg aagtggattg gtgggacatg gtctgcaacg tgaagaagct     3060

gatcaacgag aagaaagagg atggcaaggt tttctggcag aacctggccg gctacaagag     3120

acaagaagcc ctgaggcctt acctgagcag cgaagaggac cggaagaagg gcaagaagtt     3180

cgccagatac cagctgggcg acctgctgct gcacctggaa aagaagcacg gcgaggactg     3240

gggcaaagtg tacgatgagg cctgggagag aatcgacaag aaggtggaag gcctgagcaa     3300

gcacattaag ctggaagagg aaagaaggag cgaggacgcc caatctaaag ccgctctgac     3360

cgattggctg agagccaagg ccagctttgt gatcgagggc ctgaaagagg ccgacaagga     3420

cgagttctgc agatgcgagc tgaagctgca gaagtggtac ggcgatctga gaggcaagcc     3480

cttcgccatt gaggccgaga acagcatcct ggacatcagc ggcttcagca agcagtacaa     3540

ctgcgccttc atttggcaga aagacggcgt caagaaactg aacctgtacc tgatcatcaa     3600

ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa cccgaggcct tcgaggctaa     3660

cagattctac accgtgatca acaaaaagtc cggcgagatc gtgcccatgg aagtgaactt     3720

caacttcgac gaccccaacc tgattatcct gcctctggcc ttcggcaaga gacagggcag     3780

agagttcatc tggaacgatc tgctgagcct ggaaaccggc tctctgaagc tggccaatgg     3840

cagagtgatc gagaaaaccc tgtacaacag gagaaccaga caggacgagc ctgctctgtt     3900

tgtggccctg accttcgaga gaagagaggt gctggacagc agcaacatca agcccatgaa     3960

cctgatcggc gtggaccggg gcgagaatat ccctgctgtg atcgccctga cagaccctga     4020

aggatgccca ctgagcagat tcaaggactc cctgggcaac cctacacaca tcctgagaat     4080

cggcgagagc tacaaagaga agcagaggac aatccaggcc aagaaagagg tggaacagag     4140

aagagccggc ggatactcta ggaagtacgc cagcaaggcc aagaatctgg ccgacgacat     4200

ggtccgaaac accgccagag atctgctgta ctacgccgtg acacaggacg ccatgctgat     4260

cttcgagaat ctgagcagag gcttcggccg gcagggcaag agaaccttta tggccgagag     4320

gcagtacacc agaatggaag attggctcac agctaaactg gcctacgagg gactgagcaa     4380

gacctacctg tccaaaacac tggcccagta tacctccaag acctgcagca attgcggctt     4440

caccatcacc agcgccgact acgacagagt gctggaaaag ctcaagaaaa ccgccaccgg     4500

ctggatgacc accatcaacg gcaaagagct gaaggttgag ggccagatca cctactacaa     4560

caggtacaag aggcagaacg tcgtgaagga tctgagcgtg gaactggaca gactgagcga     4620

agagagcgtg aacaacgaca tcagcagctg gacaaagggc agatcaggcg aggctctgag     4680

cctgctgaag aagaggttta gccacagacc tgtgcaagag aagttcgtgt gcctgaactg     4740

cggcttcgag acacacgccg atgaacaggc tgccctgaac attgccagaa gctggctgtt     4800

cctgagaagc caagagtaca agaagtacca gaccaacaag accaccggca acaccgacaa     4860

gagggccttt gtggaaacct ggcagagctt ctacagaaaa aagctgaaag aagtctggaa     4920

gcccgccgtg actagtccaa aaaagaagag aaaggtagcc ctcgagtacc catatgatgt     4980

ccctgactac gcttga                                                     4996


<210>  901
<211>  5401
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP59 plasmid sequence

<400>  901
atggccgctg tggaaggcga tctggacgtg caagccctga ccgatctgtt caacaacctg       60

ggcatcaacc gggacccccg gcaccgggaa gtgatcgccc tgcggatgac aggcggctgg      120

tggggccctg ccaccagata caacctgatc accgtgctgc tgcaggatga tcagggtcag      180

cctcttcagc agccccggtg gcgggccgag ggccgggccg ccaaccccgc tgtgatgctg      240

accctggaag ccccatggca ggacctgcgg atggcctttg acaacgtcga cctggccgac      300

gacacactgc ggtttggccc tctggctaac ggcaattaca tccccggcga cgagtacagc      360

ctggagttca tccctcccgc catgcaagag atcgcccaaa tgcagagaga tgagctggaa      420

aacgtgctgg acattgtggg ccagatcaca atgcagatga gcgacctgat cggaatgcag      480

gacgcccaga tccggggcct ggagggccaa atcagaggcc tgagaggcaa tctgcccgtg      540

gccggaacac caccacctcc tcctccaagc ctggacctgc agcctgccgc cgccagcagc      600

ccttacgtgg cccctgcgtc tagcgctcct gccgcacccg tggcctctgc tgatctgggc      660

tggttcgccg ggggaccttc cccaggctct gtggaccctc ggctggcccg ggtcgcctac      720

aaccccttcc tgcccggacc tagcgacggc agcggcgtgg ccccggtgca gccctccgcc      780

cctcctgccg ccagccctct gctgcccctg ccacctgctc agcctgtgca gccagtgatc      840

cagtacgtgc accctcctcc tatgaaccct gcccagcaga ttattcctat ccagcacatc      900

agagccgtga ccggcaacgc ccccaccaac cctagagaga tccctatgtg gatcggcaga      960

aacgccagcg ccatcgaggg cgtgttcccc atgaccaccc ctgatctgag gtgtcgggtg     1020

atcaacgccc tgctcggcgg caacctgggc ctgaacctgg aaccacagca ctgcgtgacc     1080

tgggccagcg caatcgccac cctgtacgtt agaacccacg gcagctaccc catccaccag     1140

ctggctgaag tgctgagagg cgtggctaat agcgagggag ttgctgccgc ttatcagctg     1200

ggcatgatgc tgacaaaccg ggattacaac ctgatctggg ggatcatccg ccctctgctg     1260

cccggccagg ccgtcgtgac cgccatgcag catagactgg atcaggagat caacgacgcc     1320

gccagagtgg cctctttcat caatcacctg aacggcgtgt acgagctgct gggcttgaac     1380

gccagaggcc agagcctgag aatccctgcc tctggcggac agaccacggc cggaaccagc     1440

gccggcagag gcacaagagg aagacgcagc cagcaaggca cacctggcag acagagcagc     1500

ggccagagcc agcagcaggg aagaagaagc agccagggcc agagcagaca gtcagactcc     1560

agcgaccaga acgtgcagag acaatcccag ggcggcaacg gacggggagg ctataatctg     1620

agacccagga cctaccagcc ccagagatac ggcggaggca gaggcagaag gtggaacgac     1680

cagcctgcca gatcagacaa ccagcagcgg tcccaatctc aacagcctca gtccgaggct     1740

agaggcgagc agagcagaac cagcggagcc ggcagaggac agggcggccg ggggaatcaa     1800

aacagaaacc agagaagcgc cggtggcaat gccgacagaa cagtgaacac cgtgacaacc     1860

gccagcgctt ctacaagcgc ctcaggtcaa gatggatcct ctccagctcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaattaaa agcccactgg gacagcggag ccaccattac     1980

atgcatcccc gaggcttttc tggaagatga gcagcctatc caaacaatgc tgatcaagac     2040

catccacggc gagaagcagc agaacgtgta ctacctgaca ttcaagatcc agggcagaaa     2100

ggtggaagcc gaggtgctgg cctctcctta tgactacatc ctgctcaatc cttctgatgt     2160

gccatggctg atgaaaaagc ctctgcaact gaccgtgctg gtccccctgc aggactacca     2220

ggagcggctg ctgaaacaga ccaccctgcc taaggaacag aaggaccagc tggaaaagct     2280

gttcctgaag tacgacgccc tgtggcagca ctgggagaac caggtgggcc acagaagagg     2340

tgccagaaca gtgaacaccg tgacaaccgg cggcagccca aagaagaagc ggaaggtctc     2400

tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac     2460

aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga     2520

cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag     2580

caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc     2640

catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt     2700

tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa     2760

gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta     2820

caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa     2880

cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga     2940

tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat     3000

ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag     3060

atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag     3120

cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca     3180

gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt     3240

gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc     3300

cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga     3360

cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc     3420

caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa     3480

agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag     3540

gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct     3600

gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga     3660

tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga     3720

agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc     3780

caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg     3840

cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc     3900

cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg     3960

gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg     4020

caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt     4080

gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc     4140

caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa     4200

cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa     4260

aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt     4320

cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga     4380

ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag     4440

cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa     4500

agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata     4560

ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc     4620

cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag     4680

cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat     4740

ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa     4800

aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc     4860

cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat     4920

caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca     4980

gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa     5040

cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag     5100

gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca     5160

cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga     5220

gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga     5280

aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag     5340

tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg     5400

a                                                                     5401


<210>  902
<211>  5401
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP60 plasmid sequence

<400>  902
atggccgcca tcgagggcga tctggacgtg caggccctgg ctaacctgtt caacgacctg       60

ggcatcaaca gaaaccccag acacagagag gtgattgccc tgagaatgac cggcggctgg      120

tggggccccg ctaccagata taatctggtg agcctgctgc tgcaggacga ccagggccag      180

cctctgccac agcccagatg gcgggctgaa ggcagagccg caaaccccgc cgtgatgttc      240

accctggaag ccccctggca ggatctgaga ctggcctttg acaatatcga cgtgggcgag      300

ggcacactga gattcggccc acttgctaac ggcaactaca tccccggcga cgagttcagc      360

ctggagttcc tgcctcctgc catgcaggag atcacacaga tgcagagaga tgagctggag      420

gaagtgctgg atgtggtggg ccagatcaca atgcagatga acgacctgat cggcatgcag      480

gacgcccaga tccggggact ggaaggacaa ctgagaggac tgagaggcaa tctgccagtg      540

gccggcacac ctccacctcc tccacccagc ctggacctgc agcctgctgc cgccagcagc      600

ccctacgtgg cccctgcacc ttccgctcct gctgcctctg ccgccgcagc cgacctggga      660

tggttcgccg gaggccctgg ccctggatct ctggaccccc gcctcgcccg ggtggcctac      720

aacccctttc tgcctggccc tagcgacggc agcggtgccg ctcccgccca gcctagcgct      780

cctccggtgg cctctcctct gccttctctg ctgcctgccc agcccatgca acctgtgatc      840

cagtacgtgc accccccacc tatcaatcct gctcaacagg tgatccctat tcagcatatc      900

agagccgtga ccggcaacgc ccctagcaac ccaagagaaa tccctatgtg gatcggaaga      960

aacgccagcg ccatcgaggg cgtgttcccc atccctacat ctgacatccg ttctagagtg     1020

atcaacgccc tgctgggtag acagctgggc ctgaacctgg atcctcagca ctgcatcacc     1080

tgggccagcg caatcgccac tctgtacgtg cgcacccacg gcagctaccc tctgcaccag     1140

ctggccgagg ttctgcggag agtctccaac agcgaaggcg cggccgccgc ctggcagctg     1200

ggcatgatgc tgaccaacca ggactacaac ctcgtgtggg gaatggtcag acccctgctg     1260

cccggccagg ctgtggtcac cgccatgcag caccggctgg atcaggaggt ttctgatgcc     1320

gccagaatcg tgtccttcgt gaaccacctg aacgccgtgt acgagctgct gggcctgaat     1380

gccagaggcc agaacctcag ggtctccacc ggcggccaga ccaccgctag aacaagcgcc     1440

ggcagaggcg ccagaggcag acggtcccag caggggaccc ctggcaggca gtctagcgga     1500

caggcccctc ctcaaggccg gagaagcagc cagggccagc agcctaggca gtctgagagc     1560

ggcgaccaga acaaccagcg gcagctccag ggaggaaaca accggggcgg ctataacctg     1620

cggcctcgga cataccagcc tcagcggtac gggggaggcc ggggccggag atggaacgat     1680

cagaccgcca gagccgataa ccagcagcgg agccaatccc aacaacctca gagcgaggcc     1740

cggggcgagc agagcagaac cagcggcgcc ggcagagaac agggcggcag aggcaatcaa     1800

aatcggaatc aaagatctgc cggagaaaac accgacagat ccgtgaacac cgtgacagcc     1860

accagcgcca gcatcagcgc ctcaggtcaa aatggatcct ctacaactcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaattaaa agcccactgg gatagcggag ctacaatcac     1980

ctgcgtgccc gaggcctttc tggaagatga gagacctatc cagaccatgc tgatcaagac     2040

catccacggc gagaagcagc aggacgtcta ctacctgacc ttcaaggtgc agggcagaaa     2100

ggtggaagcc gaggtgctgg cctctcctta tgactacatc ctgctcaacc ccagcgacgt     2160

gccttggctg atgaaaaagc ctctgcagct gacagtgctg gtgccactgc acgagtacca     2220

ggagcggctg ctgcaacaaa ccgccctgcc taaggaacag aaagagctgc tgcagaagct     2280

gttcctgaag tacgacgccc tgtggcagca ttgggaaaac caggtgggcc accggagagg     2340

tgccagatcc gtgaacaccg tgacagccgg cggcagccca aagaagaagc ggaaggtctc     2400

tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac     2460

aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga     2520

cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag     2580

caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc     2640

catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt     2700

tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa     2760

gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta     2820

caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa     2880

cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga     2940

tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat     3000

ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag     3060

atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag     3120

cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca     3180

gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt     3240

gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc     3300

cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga     3360

cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc     3420

caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa     3480

agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag     3540

gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct     3600

gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga     3660

tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga     3720

agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc     3780

caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg     3840

cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc     3900

cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg     3960

gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg     4020

caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt     4080

gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc     4140

caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa     4200

cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa     4260

aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt     4320

cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga     4380

ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag     4440

cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa     4500

agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata     4560

ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc     4620

cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag     4680

cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat     4740

ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa     4800

aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc     4860

cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat     4920

caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca     4980

gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa     5040

cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag     5100

gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca     5160

cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga     5220

gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga     5280

aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag     5340

tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg     5400

a                                                                     5401


<210>  903
<211>  5811
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP61 plasmid sequence

<400>  903
atggggcaag aattaagcca gcatgaacgt tatgtagaac aattgaagca ggctttaaag       60

acacggggag taaaggttaa atatgctgat cttttgaaat tttttgattt tgtgaaggat      120

acttgtcctt ggtttccgca agagggaacc atagatatta aacggtggcg tagagtaggc      180

gactgtttcc aagactatta caatactttt ggcccggaga aagtcccagt aactgcattc      240

tcttactgga acttaattaa agaattgata gataagaaag aagttaaccc acaagtaatg      300

gctgccgtag cccaaactga agaaatttta aaaagtaatt ctcaaacaga cctcacaaag      360

acctctcaaa acccagactt ggaccttatt tcccttgata gcgacgatga aggagctaaa      420

agttcctctc tacaagataa aggtttatca agtactaaaa aaccaaaaag attcccagtt      480

ctgttaacag cacaaactag taaagaccct gaagacccca acccctcaga ggtagactgg      540

gacggcttgg aagatgaggc agcgaaatat cataatcccg attggcctcc cttcctaacc      600

cgtccacctc cttacaataa agctactcct tccgcaccca ctgtaatggc ggttgttaat      660

ccaaaagagg agctcaaaga aaaaattgct caattagagg aacagattaa attagaagag      720

ttacaccagg cactaatttc caaattacaa aaactaaaaa cagggaatga aactgtaact      780

cacccagaca cagcaggagg cctttctcgc acgcctcact ggccagggca acatatccct      840

aaaggaaaat gttgcgccag tcgagaaaag gaagaacaaa tcccaaaaga tattttccca      900

gtgactgaaa ccgttgatgg gcaaggtcaa gcctggagac accataatgg ttttgatttt      960

gccgtcataa aagaattaaa aacagctgct tcccaatatg gggctactgc cccatacaca     1020

ttagccatag tggaatctgt agcggacaat tggcttaccc ctacagattg gaatacgctt     1080

gttagggcag tcctctcagg aggagatcac ttactgtgga aatctgagtt ttttgaaaat     1140

tgcagagata cggctaaaag aaaccaacaa gccggtaatg gctgggattt tgacatgtta     1200

acaggttcgg gtaattattc cagcaccgat gcacaaatgc agtatgatcc aggattgttt     1260

gctcaaattc aagcggctgc tacaaaagcc tggagaaaac ttcccgttaa gggagaccca     1320

ggagcctccc ttacaggagt caaacaagga cccgatgagc catttgcaga tttcgtacac     1380

agacttataa caactgctgg gagaatcttt ggaagtgctg aggccggtgt agactatgta     1440

aaacaactag catatgaaaa tgctaatcca gcttgtcagg cagccattcg cccctataga     1500

aagaagacag atttaactgg ctatatccgt ctttgctcgg atattgggcc ctcttatcag     1560

caaggcctgg ccatggccgc cgcctttagc gggcagactg taaaagattt tcttaacaac     1620

aaaaataaag agaaaggagg gtgttgcttt aaatgcggta aaaaaggaca ctttgcaaaa     1680

aattgtcatg aacatgcaca taacaatgct gaaccaaaag ttcccggact ctgccctaga     1740

tgtaaaagag ggaaacattg ggccaatgaa tgcaaatcca aaactgataa tcaaggaaac     1800

ccaataccac cccatcaggg aaacggggcc agccccaggc cccgaaacaa gcttatgggg     1860

cagtcagctt tgttccagcc aacaaaaaca acccatttca aagcttacca gagccacccc     1920

aggaagtgca ggattggacc tctgttccac ctcccacaca gtattaacgc ctgaaatggg     1980

gccccaagcg ttaagcactg gaatatatgg accactgcct cccaacactt ttggattaat     2040

cctaggccga agtagcatta ctatgaaggg tctacaagtt tatccaggag taattgataa     2100

tgactatacc ggagaaatta aaattatggc aaaagctgtt aacaatattg ttactgtctc     2160

tcaaggcaac agaatagctc aattaatcct cctgcctctg atcgagacag acaataaggt     2220

acaacaacct tatagaggac aaggaagttt tggatcctca gacatatatt gggtccaacc     2280

tattacttgt caaaaacctt ccttaacatt atggttagat gacaaaatgt tcacaggctt     2340

aatagatacg ggggctgatg tcacaattat caagctggag gactggcctc ctaattggcc     2400

tataacagat accttaacca atttaagagg aataggacaa agtaacaacc ctaaacaaag     2460

ttctaaatat cttacttgga gagataaaga aaacaattct ggtctcatca aaccgtttgt     2520

tattcctaac ttacctgtca atctttgggg ccgagattta ctttctcaaa tgaaaattat     2580

gatgtgtagc cccaatgaca tagtaactgc tcaaatgtta gcccagggct acagcccagg     2640

aaaagggtta ggaaaaaagg aaaatggcat tctacatcct atcccaaatc aaggacaatc     2700

taacaaaaaa ggttttggaa atttttaact gcggccattg acatacttgg tgccccacag     2760

gtgatggctg ctgtcgccgg cggcagccca aagaagaagc ggaaggtctc tagacaagag     2820

atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac aaagaaggcc     2880

ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga cctgagagag     2940

cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag caacaccagc     3000

agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc catcctgcac     3060

gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt tgctcagcct     3120

gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa gggcaatctg     3180

accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta caagctggaa     3240

caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa cgtggccgag     3300

cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga tgaggccgtg     3360

acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat ccacgtgacc     3420

aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag atacgcctct     3480

ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag cttcctgagc     3540

aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca gaagagactg     3600

gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt gaccctgcct     3660

cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc cagagtgaga     3720

atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga cgccaagcct     3780

ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc caatgaagtg     3840

gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa agaggatggc     3900

aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag gccttacctg     3960

agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct gggcgacctg     4020

ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga tgaggcctgg     4080

gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga agaggaaaga     4140

aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc caaggccagc     4200

tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg cgagctgaag     4260

ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc cgagaacagc     4320

atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg gcagaaagac     4380

ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg caagctgcgg     4440

ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt gatcaacaaa     4500

aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc caacctgatt     4560

atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa cgatctgctg     4620

agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa aaccctgtac     4680

aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt cgagagaaga     4740

gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga ccggggcgag     4800

aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag cagattcaag     4860

gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa agagaagcag     4920

aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata ctctaggaag     4980

tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc cagagatctg     5040

ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag cagaggcttc     5100

ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat ggaagattgg     5160

ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa aacactggcc     5220

cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc cgactacgac     5280

agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat caacggcaaa     5340

gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca gaacgtcgtg     5400

aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa cgacatcagc     5460

agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag gtttagccac     5520

agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca cgccgatgaa     5580

caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga gtacaagaag     5640

taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga aacctggcag     5700

agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag tccaaaaaag     5760

aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg a              5811


<210>  904
<211>  5077
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP62 plasmid sequence

<400>  904
atgggccaaa tcttttcccg tagcgctagc cctattccgc gaccgccccg ggggctggcc       60

gctcatcact ggcttaactt cctccaggcg gcatatcgcc tagaacccgg tccctccaat      120

tgcgctttcc acctgttaag aagatatcat gaaacagttt ccggaatacc ggctcggatc      180

tgtcccatta actactccct cctagccagc ctactcccaa aaggataccc cggccgggtg      240

aatgaaattt tacacatact catccaaacc caagcccaga tcccgtcccg tcccgcgcca      300

ccgccgccgt catcccccac ccacgacccc ccggattctg atccacaaat cccccctccc      360

tatgttgagc ctacggcccc ccaagtcctt ccagtcatgc atccacatgg tgctcctcct      420

aaccatcgcc catggcaaat gaaagaccta caggccatta agcaagaagt ctcccaagca      480

gcccctggga gcccccagtt tatgcagacc atccggcttg cggtgcagca gtttgacccc      540

actgccaaag acctccaaga cctcctgcag tacctttgct cctccctcgt ggcttccctc      600

catcaccagc agctagatag ccttatatca gaggccgaaa cccgaggtat tacaggttat      660

aacccattag ccggtcccct ccgtgtccaa gccaacaatc cacaacaaca aggattaagg      720

cgagaatacc agcaactctg gctcgccgcc ttcgccgccc tgccggggag tgccaaagac      780

ccttcctggg cctctatcct ccaaggcctg gaggagcctt accacgcctt cgtagaacgc      840

ctcaacatag ctcttgacaa tgggctgcca gaaggcacgc ccaaagaccc catcttacgt      900

tccttagcct actccaatgc aaacaaagaa tgccaaaaat tactacaggc ccgaggacac      960

actaatagcc ctctaggaga tatgttgcgg gcttgtcaga cctggacccc caaagacaaa     1020

accaaagtgt tagttgtcca gcctaaaaaa ccccccccaa atcagccgtg cttccggtgc     1080

gggaaagcag gccactggag tcgggactgc actcagcctc gtcccccccc cgggccatgc     1140

cccctatgtc aagacccaac tcactggaag cgagactgcc cccgcctaaa gcccactatc     1200

ccagaaccag agccagagga agatgccctc ctattagacc tccccgctga cattccacac     1260

ccaaaaaact ccataggggg ggaggtttaa cctccccccc cacattacag caagtctttc     1320

ttaaccaaga cccagcatct attctgccag ttataccgtt agatcccgcc cgtcggcccg     1380

taattaaagc ccaggttgac acccagacca gccacccaaa gactatcgaa gctctactag     1440

atacaggagc agacatgaca gtccttccga tagccttgtt ctcaagtaat actcccctca     1500

aaaatacatc cgtattaggg gcagggggcc aaacccaaga tcactttaag ctcacctccc     1560

ttcctgtgct aatacgcctc cctttccgga caacgcctat tgttttaaca tcttgcctag     1620

ttgataccaa aaacaactgg gccatcatag gtcgcgatgc cttacaacaa tgccagggcg     1680

tcctgtacct ccctgaggca aaagggccgc ctgtaatctt gccaatacag gcgccagccg     1740

tccttggact agaacacctc ccaaggcccc cccaaatcag ccagttccct ttaaaccaga     1800

acgcctccag gccttgcaac acttggtccg gaaggccctg gaggcaggcc atatcgaatc     1860

ctacaccggg ccaggaaata acccagtatt cccagttaaa aaggccaatg gaacctggcg     1920

attcatccac gacctgcggg ccactaactc tctaaccata gacctctcat catcttcccc     1980

cgggccccct gacttgtcca gcctgccaac cacacgtgcc cctcaagtgc tgccagtgat     2040

gcacggcggc agcccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa     2100

caagatcaga aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc     2160

catgaaaacc ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct     2220

gagaaagaag cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa     2280

caagctgctg accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga     2340

gttccagaaa gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat     2400

cgaccagaac aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt     2460

tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa     2520

aggcaaggcc tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat     2580

tctgctggcc cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg     2640

caagtttgga cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca     2700

ccccgtgaag cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa     2760

agccctgtcc gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat     2820

catcatcgag caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga     2880

gctggccggc aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac     2940

aaaagaaggc gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct     3000

gaacctgtgg cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa     3060

gggcttccct agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat     3120

ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca     3180

gaacctggcc ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga     3240

ccggaagaag ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga     3300

aaagaagcac ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa     3360

gaaggtggaa ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc     3420

ccaatctaaa gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg     3480

cctgaaagag gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta     3540

cggcgatctg agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag     3600

cggcttcagc aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact     3660

gaacctgtac ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa     3720

acccgaggcc ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat     3780

cgtgcccatg gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc     3840

cttcggcaag agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg     3900

ctctctgaag ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag     3960

acaggacgag cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag     4020

cagcaacatc aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt     4080

gatcgccctg acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa     4140

ccctacacac atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc     4200

caagaaagag gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc     4260

caagaatctg gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt     4320

gacacaggac gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa     4380

gagaaccttt atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact     4440

ggcctacgag ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa     4500

gacctgcagc aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa     4560

gctcaagaaa accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga     4620

gggccagatc acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt     4680

ggaactggac agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg     4740

cagatcaggc gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga     4800

gaagttcgtg tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa     4860

cattgccaga agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa     4920

gaccaccggc aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa     4980

aaagctgaaa gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc     5040

cctcgagtac ccatatgatg tccctgacta cgcttga                              5077


<210>  905
<211>  4871
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP63 plasmid sequence

<400>  905
atgggcgcga gaaactccgt cttgtcaggg aaggaagcag atgaattaga aaaagttagg       60

ttacggccca acggaaagaa aaagtatatg ttgaagcatg tagtatgggc agcaaatgaa      120

ttggacagat ttggattagc agaaagcctg ttggataaca aagaaggttg tcaaaaaatt      180

ctttcagttt tagctccatt agttccgaca ggttcagaaa acttaaagag cctttataat      240

actgtctgcg tcatttggtg cattcacgca gaagagaaag tgaaacatac tgaggaagca      300

aaacaaatag tgcagagaca tctagtggtg gaaacaggaa cagcagacag aatgccagca      360

acaagcagac caacagcacc acctagtggc agaggaggaa attacccagt gcagcaagta      420

ggtggcaatt atgtccacct acccttaagt ccaagaacat taaatgcttg ggtaaaatta      480

gtagaagaga aaaaatttgg ggcagaggta gtgccaggat ttcaagcgct atcagaaggc      540

tgcactccct atgatattaa tcaaatgcta aattgtgtag gagaacatca ggcagccatg      600

caaattatta gagagattat aaatgaagaa gctgccgatt gggatttaca acacccgcaa      660

ccaggtccac taccagcagg gcaacttaga gagccaagag gatcagacat tgcaggaact      720

actagtacag tagatgaaca aatccaatgg atgtacaggc aacaaaaccc cataccagta      780

ggcaacattt atagaaggtg gatccaatta gggctgcaga aatgtgtaag aatgtataac      840

ccaacaaaca ttttagatgt gaaacaagga ccaaaagagc catttcaaag ctacgtagat      900

agattctaca aaagtctaag agcagagcaa acagatcccg cagtaaagaa ttggatgacc      960

caaacactgc tgattcaaaa tgctaaccca gattgtaaac tagtgctcaa gggtctgggc     1020

atgaatccca ctttagaaga aatgctgaca gcctgtcagg gagtaggagg gccaggacaa     1080

aaagctaggt taatggcaga agcattgaaa gaggcactga ggccagatca actcccattt     1140

gcagcagtcc aacagaaagg acaaaggaag acaatcaagt gttggaattg tggaaaggag     1200

ggacactctg caaaacaatg cagggcccct agaagacagg gctgctggaa gtgtggaaaa     1260

acgggtcatg ttatggccaa atgccctgaa agacaggcgg gttttttagg gcttggccca     1320

tggggaaaga agccccgcaa tttccccatg gcccagatgc ctcaggggct gataccaact     1380

gctcccccag aggatccagc tgtggatcta ctgaagaatt acatgaagat gggcagaaag     1440

cagagggaga acagagagag accttacaag gaggtgacag aggatttgct gcacctcaat     1500

tctctctttg gagaagacca gtagtcactg cctacattga agaacagccc gtagaagtat     1560

tattagatac aggggctgac gattcaattg tagcagggat agaattgggt ccaaattata     1620

cccctaaaat agtaggagga ataggaggct tcattaacac caaagaatat aaagatgtaa     1680

aaataaaagt cttaggcaag gtaattaagg gaacaattat gacgggagat accccaatta     1740

atatttttgg cagaaatttg ctaacagcta tgggcatgtc tttaaatctc cccatagcta     1800

aggtggaggg tgccggcggc aactaccccg tgcagcaagg cggcagccca aagaagaagc     1860

ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg     1920

acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga     1980

tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc     2040

agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga     2100

tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga     2160

tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga     2220

tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc     2280

tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg     2340

gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga     2400

aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact     2460

tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg     2520

ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa     2580

caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca     2640

agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat     2700

accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg     2760

aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt     2820

ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg     2880

aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca     2940

acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag     3000

aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca     3060

gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca     3120

aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca     3180

ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt     3240

ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt     3300

tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg     3360

ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg     3420

ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact     3480

tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat     3540

tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact     3600

tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt     3660

tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag     3720

tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg     3780

ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga     3840

tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat     3900

gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg     3960

agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag     4020

ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc     4080

gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg     4140

agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt     4200

acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct     4260

acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca     4320

tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga     4380

tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt     4440

acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga     4500

gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc     4560

tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct     4620

tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga     4680

gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg     4740

cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg     4800

ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg     4860

actacgcttg a                                                          4871


<210>  906
<211>  4805
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP88 plasmid sequence

<400>  906
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccaaag aagaagcgga     1800

aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg gtcaaggaca     1860

gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc agagtgatga     1920

cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac atccctcagc     1980

ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac accgagatga     2040

agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg ggcctgatga     2100

gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag cccgagatgg     2160

acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc cagcctctgt     2220

tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac tacttcggca     2280

gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa cctgagaagg     2340

actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc ctggacttct     2400

acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct cagatcgccg     2460

gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc atgggaacaa     2520

tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag gtggtcaagg     2580

gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac ctggaatacc     2640

ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc tacaacgaag     2700

tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg aaactgtcca     2760

gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct ctggtggaaa     2820

gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag ctgatcaacg     2880

agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag agacaagaag     2940

ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag ttcgccagat     3000

accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac tggggcaaag     3060

tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc aagcacatta     3120

agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg accgattggc     3180

tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag gacgagttct     3240

gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag cccttcgcca     3300

ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac aactgcgcct     3360

tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc aattacttca     3420

aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct aacagattct     3480

acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac ttcaacttcg     3540

acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc agagagttca     3600

tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat ggcagagtga     3660

tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg tttgtggccc     3720

tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg aacctgatcg     3780

gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct gaaggatgcc     3840

cactgagcag attcaaggac tccctgggca accctacaca catcctgaga atcggcgaga     3900

gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag agaagagccg     3960

gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac atggtccgaa     4020

acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg atcttcgaga     4080

atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag aggcagtaca     4140

ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc aagacctacc     4200

tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc ttcaccatca     4260

ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc ggctggatga     4320

ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac aacaggtaca     4380

agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc gaagagagcg     4440

tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg agcctgctga     4500

agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac tgcggcttcg     4560

agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg ttcctgagaa     4620

gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac aagagggcct     4680

ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg aagcccgccg     4740

tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat gtccctgact     4800

acgct                                                                 4805


<210>  907
<211>  2413
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pStx42.174.12.7 plasmid sequence

<400>  907
gctagctagg tctagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt       60

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa      120

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt      180

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa      240

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac      300

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt      360

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt      420

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat      480

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac      540

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg      600

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc      660

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa      720

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag      780

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct      840

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat      900

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa      960

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     1020

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     1080

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     1140

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     1200

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     1260

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     1320

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     1380

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     1440

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     1500

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     1560

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     1620

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     1680

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     1740

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     1800

ccgacaggcc cgaaggaata gaagaagaag gtggagagag agacagagac agatccattc     1860

gattagtgaa cggatctcga cggtatcgcc tttaaaagaa aaggggggat tggggggtac     1920

agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa agaactacaa     1980

aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag agatccagtt     2040

tgagggccta tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga     2100

gataattgga attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag     2160

aaagtaataa tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca     2220

tatgcttacc gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg     2280

acgaaacacc actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc     2340

gtagtgggta aagctccctc ttcggaggga gcatcaaagc tgcattctag ttgtggtttt     2400

tttttttgaa ttc                                                        2413


<210>  908
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 plasmid sequence

<400>  908
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  909
<211>  4530
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP64 plasmid sequence

<400>  909
atggaagccg tgatcaaggt gatcagctcc gcatgcaaga cctactgtgg caagacgagc       60

ccaagcaaga aggaaatcgg cgctatgctg agcctgctgc agaaggaggg cctcctgatg      120

agcctgtctg atctgtacag cccaggtagc tgggacccta tcaccgccgc cctgacacag      180

agagccatgg tgctgggcaa aagcggcgag ctgaagacat ggggactggt gctgggcgcc      240

ctgaaagccg ctagagaaga gcaagtaacc agcgagcagg ccaagttctg gctgggactg      300

ggcggcggta gagtgagccc ccctggccct gagtgcatcg agaagcctgc caccgagcgg      360

cgcattgaca aaggcgaaga agtgggcgag acaaccgtgc agagagacgc caagatggct      420

ccagaagaga cagcaacccc aaagaccgtg ggcaccagct gctaccactg cggcaccgct      480

atcggctgca actgcgccac cgccagcgcg cctcctcccc cgtatgtggg cagcggcctc      540

tacccctccc tggcaggagt gggagagcag cagggccagg gcggagatac acccagaggc      600

gccgagcagc ctagagccga acccggccac gccggccagg cccctggccc cgccctgacc      660

gactgggcca gaatcagaga ggagctggcc tctacaggcc ctccagtggt cgccatgcct      720

gtggtgatca agaccgaggg acctgcctgg acccctctgg aacctaaact gattacacgg      780

ctggctgata ccgtcagaac caagggcctc agaagcccca tcacaatggc cgaagtggaa      840

gccctgatga gcagcccact gctgcctcac gacgtgacca acctgatgcg ggtgatcctg      900

ggccccgccc cttacgccct gtggatggac gcctggggcg tgcagctgca aacagttatc      960

gccgccgcca caagagaccc ccggcaccca gccaacggcc agggcagagg cgagagaaca     1020

aacctggatc ggctgaaggg cctcgccgat ggcatggccg gcaatcctga gggccaggct     1080

gctctgctga gacccgggga actggttgct atcaccgcca gcgccctgca ggccttcaga     1140

gaagtggccc ggctggccga gcctacagac ccctgggccg agatcaccca gggcccttct     1200

gagagcttcg tggacttcgc caacagactg atcaaggccg ttgagggctc cgacctgcct     1260

cctagcgccc gcgcccccgt gatcatcgac tgttttagac agaaatcgca acccgacatc     1320

cagcagctga tccgggccgc tccttctacc ctgaccacac ctggcgagat catcaagtac     1380

gtgctggaca gacagaagac cgcccccctg accgacagag gaatcgccgc cgccatgtct     1440

agcgccattc agcctctggt gatggccgtg gtcaacagag aaagagatgg acagacaggc     1500

ggcagcccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc     1560

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa     1620

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag     1680

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg     1740

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag     1800

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag     1860

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc     1920

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag     1980

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg     2040

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt     2100

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg     2160

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg     2220

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc     2280

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc     2340

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa     2400

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg     2460

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     2520

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     2580

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     2640

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     2700

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     2760

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     2820

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     2880

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     2940

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     3000

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     3060

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     3120

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     3180

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     3240

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     3300

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     3360

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     3420

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     3480

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     3540

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     3600

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     3660

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     3720

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     3780

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     3840

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     3900

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     3960

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     4020

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     4080

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     4140

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     4200

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     4260

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     4320

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     4380

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     4440

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt agccctcgag     4500

tacccatatg atgtccctga ctacgcttga                                      4530


<210>  910
<211>  4527
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP65 plasmid sequence

<400>  910
atggaggccg tgatcaaggt gatcagcagc gcatgcaaga cctactgcgg caagaccagc       60

ccatctaaga aagagatcgg cgccatgctg agcctgctcc aaaaggaagg cctgctgatg      120

agcccttccg acctgtacag ccccggaagc tgggacccaa tcaccgctgc cctgacccag      180

cgggccatgg tgctgggaaa gagcggcgag ctgaagacct ggggcctggt gctgggagcc      240

ctgaaggccg ccagagagga acaagtgaca agcgaacagg ccaagttctg gctgggactg      300

ggcggaggaa gagtcagccc tcctggccca gagtgcatcg agaagcccgc tacagagaga      360

agaatcgata agggcgaaga ggtgggcgag acaacagtgc agagagacgc caagatggct      420

cctgaggaaa ccgccacacc taagaccgtg ggcacatctt gttaccactg cggcaccgcc      480

attggatgta actgcgctac agccagcgcc cccccccctc cctacgtggg cagcggactt      540

tatcctagcc tggccggcgt gggagagcag cagggccaag gcggagatac acccagaggc      600

gccgagcagc ctagagccga acccggccac gccggactgg cccctggccc agccctgacc      660

gactgggccc gcatccggga agaactggct tctaccggcc ccccggtggt cgccatgcct      720

gtggttatca agacagaggg ccctgcttgg acccctctgg aaccaaagct gattacaaga      780

ctcgccgaca ccgtgcggac caagggcctg cggagcccta tcaccatggc cgagatggaa      840

gctctgatga gcagcccact gctgccccac gacgtgacca acctgatgag agtgatcctg      900

ggccccgccc cttacgccct gtggatggac gcctgggggg tgcagctgca gaccgtgatt      960

gccgccgcca ccagagatcc tagacaccct gctaacggcc aaggcagagg cgaaagaacc     1020

aaccttgaca gactgaaagg cctggccgat ggaatggtcg gcaacagcga aggccaggcc     1080

gccctgctga gacctggcga gctggtggct atcacagcca gcgccctgca ggccttcaga     1140

gaagtggccc gactggctga gcccacggac ccttgggccg acatcatgca gggcccttct     1200

gagagcttcg tggacttcgc caatagactg atcaaggccg tcgagggcag cgatcttcct     1260

cctagcgcga gagcccctgt tatcatcgac tgcttccggc agaaaagcca gcccgacatc     1320

caacagctga tcagagccgc cccttccacc ctgaccacac caggcgagat catcaagtac     1380

gtgctggata gacagaagac cgcccctctg accgatcagg gcatcgccgc tgccatgtcc     1440

tctgccatcc agcctctggt gatggccgtg gtgaacagag agagagacgg ccagggcggc     1500

agcccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa caagatcaga     1560

aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc catgaaaacc     1620

ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct gagaaagaag     1680

cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa caagctgctg     1740

accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga gttccagaaa     1800

gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat cgaccagaac     1860

aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt tgcctgctct     1920

cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa aggcaaggcc     1980

tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat tctgctggcc     2040

cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg caagtttgga     2100

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag     2160

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc     2220

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag     2280

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc     2340

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc     2400

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg     2460

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     2520

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     2580

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     2640

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     2700

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     2760

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     2820

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     2880

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     2940

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     3000

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     3060

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     3120

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     3180

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     3240

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     3300

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     3360

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     3420

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     3480

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     3540

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     3600

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     3660

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     3720

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     3780

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     3840

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     3900

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     3960

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     4020

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     4080

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     4140

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     4200

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     4260

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     4320

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     4380

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     4440

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc cctcgagtac     4500

ccatatgatg tccctgacta cgcttga                                         4527


<210>  911
<211>  4497
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP66 plasmid sequence

<400>  911
atgggccaga cccacagcag acaactgttc gtgcacatgc tgtccgtgat gctgaagcac       60

agaggcatca ccgtgtctaa gcctaagctg atcaacttcc tgagcttcat cgaggaagtg      120

tgtccttggt ttccacggga aggcacagtg aacctggaaa catggaaaaa ggtgggcgaa      180

cagatcagaa cccactacac cctgcacggc cctgagaagg tgcctgtgga aacactttcc      240

ttctggaccc tgatccgcga ctgcctggat ttcgacaatg acgagctgaa aagactgggc      300

aacctgctca agcaggagga agatcctctg cacgaccctg acagcgagaa cagctacgac      360

gcccctcctc ctcctcatcc tagcctgcac tctagcagac cttccgacaa cgacgacctg      420

ctgtctagca cagacgaggc cgagctggac gaggaagccg ccaagtacca ccaggaggac      480

tggggcttcc tggctcagga gaaaggcgcc ctgacaagca aggacgagct ggtggaatgt      540

ttcaagaacc tgaccatcgc cctgcagaac gctggaatca agctgccagc caacaacgat      600

aagttcccct ccgccccccc tctgcctcct gcctacgccc ctagcgtggt ggccggactg      660

gatccacccc ccggccccct gcccccaagc aagaacatgt ctccactgca gaaagccctg      720

agacaagccc agaggctggg cgaagttgtg tccgatttca gcctggcctt ccccgtgttc      780

gagaacaaca accagcggta ctacgagagc ctgcctttca agcagctgaa ggaactcaaa      840

atcgcatgca gccagtacgg ccctaccgca ccttttacca tcgccatgat cgagaacctc      900

ggcacccagg ccctgccacc taatgattgg aagcagacag ccagagcctg cctgtcaggc      960

ggagattacc tgctgtggaa gagcgagttc ttcgagcaat gcgccagaat cgctgacgtg     1020

aaccggcagc agggcatcca gacgagctac gagatgctga tcggcgaggg accctaccag     1080

gccaccgaca cccagctgaa cttcctgcct ggggcctatg cccaaatcag caacgccgcc     1140

agacaggctt ggaagaaact gcctagctct tctacaaaga ccgaggacct gagcaaagtg     1200

cggcaaggcc ccgatgagcc ctaccaggac tttgtcgcca gactgctcga caccatcggc     1260

aagatcatga gcgacgaaaa ggccggcatg gtcctggcta agcaactggc tttcgagaat     1320

gctaatagcg cctgtcaggc cgccctgcgg ccttacagaa agaagggcga cctgtccgat     1380

tttatcagaa tctgcgccga catcggcccc tcttatatgc agggaattgc catggccgct     1440

gctctgcagg gcaaaagcat caagggcggc agcccaaaga agaagcggaa ggtctctaga     1500

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     1560

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     1620

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     1680

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     1740

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     1800

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     1860

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     1920

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     1980

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     2040

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     2100

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     2160

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     2220

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     2280

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     2340

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     2400

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     2460

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     2520

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     2580

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     2640

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     2700

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     2760

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     2820

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     2880

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     2940

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     3000

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     3060

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     3120

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     3180

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     3240

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     3300

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     3360

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     3420

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     3480

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     3540

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     3600

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     3660

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     3720

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     3780

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     3840

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     3900

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     3960

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     4020

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     4080

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     4140

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     4200

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     4260

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     4320

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     4380

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     4440

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        4497


<210>  912
<211>  4551
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP67 plasmid sequence

<400>  912
atgggcgtgt ccggctcaaa gggccagaag ctgtttgtgt ccgtgctgca gcgtctgctg       60

tccgaacggg gcctacacgt gaaagagagc agcgccatcg agttctacca gtttctgatc      120

aaggtgtcac cctggttccc cgaggaaggc ggcctgaatc tgcaggattg gaagagagtg      180

ggcagagaaa tgaagaagta cgccgctgag cacggcaccg acagcatccc caagcaggct      240

tatcctatct ggctgcaact gagagagatc ctgacagagc aatctgacct ggtgctgctg      300

agcgccgagg ccaagtccgt gacagaggaa gaactggaag aaggcctgac aggactgctg      360

agcgccagca gccaggagaa gacctacggc acaagaggca ccgcctatgc cgaaatcgac      420

accgaggtgg ataagctgag cgagcacatc tacgacgagc cctacgagga gaaggaaaag      480

gccgacaaga acgaggagaa ggaccacgtg cggaaggtca agaagatcgt gcaaagaaag      540

gaaaatagcg agcataagag aaaggagaaa gatcagaagg ccttcctggc aaccgactgg      600

aacaacgacg acctgagccc tgaggactgg gacgacctgg aagagcaggc cgcccactac      660

cacgatgacg acgaactgat cctgcctgtg aagagaaagg tggacaagaa gaagccgctc      720

gccctgaggc ggaaacctct gcccccggtt ggcttcgccg gagccatggc cgaggctaga      780

gagaagggcg atctgacctt cacatttccc gtggttttca tgggagaatc cgacgacgat      840

gatacccctg tgtgggaacc tctgcccctg aagacactga aggaactgca gtctgccgtg      900

cggaccatgg gccctagcgc cccttacacc ctccaggtgg tggacatggt tgcctctcag      960

tggctgacac ctagcgattg gcaccaaacc gccagagcca ccctgtctcc tggggactac     1020

gtgctgtggc ggaccgagta cgaggagaag agcaaggaaa ccgtgcagaa gaccgctggc     1080

aagcggaaag gcaaggtgag cctggatatg ctgctgggca caggtcagtt cctgagccct     1140

tcttctcaga tcaagctttc taaagatgtg ctgaaggatg tgaccaccaa cgccgtcctg     1200

gcctggagag ccatccctcc tccaggcgtc aaaaagacag tgctggccgg actcaagcag     1260

ggaaatgagg aaagctacga gacattcatc agcagactgg aagaggccgt gtacagaatg     1320

atgcctagag gagaaggcag cgacatcctg atcaagcagc tggcttggga gaacgctaat     1380

tctctgtgcc aggacctgat ccggcctatg cggaagaccg gcaccatgca ggactacatc     1440

agagcctgtc tggatgcctc ccctgccgtg gtgcagggca tggcctacgc cgccgcaatg     1500

agaggacaaa agtacagcgg cggcagccca aagaagaagc ggaaggtctc tagacaagag     1560

atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac aaagaaggcc     1620

ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga cctgagagag     1680

cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag caacaccagc     1740

agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc catcctgcac     1800

gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt tgctcagcct     1860

gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa gggcaatctg     1920

accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta caagctggaa     1980

caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa cgtggccgag     2040

cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga tgaggccgtg     2100

acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat ccacgtgacc     2160

aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag atacgcctct     2220

ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag cttcctgagc     2280

aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca gaagagactg     2340

gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt gaccctgcct     2400

cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc cagagtgaga     2460

atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga cgccaagcct     2520

ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc caatgaagtg     2580

gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa agaggatggc     2640

aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag gccttacctg     2700

agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct gggcgacctg     2760

ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga tgaggcctgg     2820

gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga agaggaaaga     2880

aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc caaggccagc     2940

tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg cgagctgaag     3000

ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc cgagaacagc     3060

atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg gcagaaagac     3120

ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg caagctgcgg     3180

ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt gatcaacaaa     3240

aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc caacctgatt     3300

atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa cgatctgctg     3360

agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa aaccctgtac     3420

aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt cgagagaaga     3480

gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga ccggggcgag     3540

aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag cagattcaag     3600

gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa agagaagcag     3660

aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata ctctaggaag     3720

tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc cagagatctg     3780

ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag cagaggcttc     3840

ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat ggaagattgg     3900

ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa aacactggcc     3960

cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc cgactacgac     4020

agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat caacggcaaa     4080

gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca gaacgtcgtg     4140

aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa cgacatcagc     4200

agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag gtttagccac     4260

agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca cgccgatgaa     4320

caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga gtacaagaag     4380

taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga aacctggcag     4440

agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag tccaaaaaag     4500

aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg a              4551


<210>  913
<211>  4638
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP68 plasmid sequence

<400>  913
atgggccagg agctgtccca gcacgagcgg tacgtggagc agctgaagca agcccttaaa       60

acaagaggcg tgaaggtgaa atacgccgac ctgctgaagt tcttcgattt tgtgaaggat      120

acctgccctt ggttccctca ggagggcacc atcgacatca agagatggcg cagagtgggc      180

gactgcttcc aagattacta caacaccttc ggacctgaga aagtgcctgt gaccgccttc      240

agctactgga acctgatcaa ggaactgatc gacaaaaagg aagtgaaccc acaggtgatg      300

gctgctgtcg cccagaccga ggaaatcctg aagagcaaca gccagacaga cctgaccaag      360

accagccaga accctgacct ggatctgatc agcctggaca gcgatgatga gggcgccaag      420

tccagcagcc tgcaggacaa gggcctgagc agcaccaaaa agcctaagcg gttccccgtc      480

ctgctgaccg cccagacaag caaggaccca gaggatccta acccaagcga ggtggactgg      540

gacggcctgg aggacgaggc cgctaagtac cacaaccctg actggccccc cttcctgaca      600

agacctccac cttacaacaa ggctacccct agcgccccta ccgtgatggc cgtggtgaac      660

cctaaagagg aactgaaaga aaagatcgcc cagctggaag agcagatcaa actggaagag      720

ctgcaccagg ccctgatttc taagctgcaa aagctgaaaa ccggcaacga gacagtcact      780

caccctgata cagccggagg cctgagcaga acaccacatt ggcccggcca gcacatccct      840

aagggcaagt gctgcgccag ccgggaaaag gaagagcaga tccccaagga tatcttccct      900

gtgaccgaaa ccgttgacgg acagggccag gcatggagac accacaatgg cttcgacttc      960

gccgtgatca aggaactgaa gacagccgcc tctcaatacg gcgccaccgc accttacacc     1020

ctggctatcg tggaatccgt cgccgacaac tggctgaccc caaccgactg gaataccctg     1080

gtgcgggccg tgctgtctgg cggcgaccac ctgctctgga agtctgagtt cttcgagaac     1140

tgtagggaca ccgctaagcg gaaccagcag gccggcaatg gatgggattt tgacatgctg     1200

accggcagcg gcaactacag ctctacagac gcccaaatgc agtacgaccc tggcctgttc     1260

gcccagattc aggccgctgc cacaaaggcc tggcggaagc tgcccgtgaa gggggatccc     1320

ggcgccagcc tgaccggcgt gaagcagggc cccgatgagc ctttcgccga cttcgtgcat     1380

agactgatca ccacagccgg cagaatcttc ggctccgccg aagccggcgt ggactacgtg     1440

aagcagctgg cttacgagaa cgccaaccct gcctgccagg ccgcaatcag accctataga     1500

aagaagacag atctgaccgg ctacatccgg ctgtgcagcg acatcggccc ttcctatcag     1560

cagggactgg ctatggccgc tgcctttagc ggccagaccg tgaagggcgg cagcccaaag     1620

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1680

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1740

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1800

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1860

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1920

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1980

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     2040

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     2100

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     2160

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     2220

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2280

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2340

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2400

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     2460

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2520

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2580

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2640

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2700

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2760

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2820

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2880

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2940

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     3000

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     3060

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     3120

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     3180

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3240

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3300

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3360

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3420

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3480

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3540

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3600

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3660

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3720

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3780

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3840

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3900

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3960

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     4020

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     4080

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     4140

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     4200

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4260

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4320

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4380

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4440

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4500

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4560

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4620

gtccctgact acgcttga                                                   4638


<210>  914
<211>  4029
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP69 plasmid sequence

<400>  914
atgggcaact ctcctagcta caatccccct gccggcatct ccccatctga ctggctgaac       60

ctgctgcagt ccgcccagcg cctgaatcca aggcctagcc catccgactt cacagatctg      120

aagaactata tccactggtt tcacaagacc cagaagaagc cttggacctt cacaagcgga      180

ggaccaacat cctgcccacc aggcagattt ggaagggtgc cactggtgct ggccaccctg      240

aacgaggtgc tgtccaatga gggaggagca cctggagcct ctgccccaga ggagcagcct      300

ccaccctacg accctccagc catcctgccc atcatctccg agggaaacag gaataggcac      360

agggcatggg cactgaggga gctgcaggat atcaagaagg agatcgagaa taaggcccct      420

ggctctcaag tgtggatcca gacactgcgg ctggccatcc tgcaggcaga cccaacccct      480

gcagatctgg agcagctgtg ccagtacatc gccagccctg tggaccagac cgcccacatg      540

acatccctga ccgcagcaat cgcagcagca gaggcagcaa cacccagcag agtgctgacc      600

cctaagaccg gcacactgac ccagcagtct gcccagccaa acgcaggcga tctgaggagc      660

cagtatcaga atctgtggct gcaggccggc aagatctccc tgctggtgct gcagctgcag      720

ccctggtcta ccatcgtgca gggacctgca gagagctccg tggagtttgt gaaccgcctg      780

cagatctccc tggccgacaa cctgccagat ggcgtgctgc ggaatcccct gctgacacct      840

ctggtcatgc agatgctgac cgagtctgtg agcaagttct gcaggggaga ggccagcgga      900

aggggaggag ccaagacagc aggactgaga accatcggac cacctaggat gaagcagcct      960

gccctgctgg tgcacacccc aggaccaaag atgcctggcg gcagcccaaa gaagaagcgg     1020

aaggtctcta gacaagagat caagagaatc aacaagatca gaaggagact ggtcaaggac     1080

agcaacacaa agaaggccgg caagacaggc cccatgaaaa ccctgctcgt cagagtgatg     1140

acccctgacc tgagagagcg gctggaaaac ctgagaaaga agcccgagaa catccctcag     1200

cctatcagca acaccagcag ggccaacctg aacaagctgc tgaccgacta caccgagatg     1260

aagaaagcca tcctgcacgt gtactgggaa gagttccaga aagaccccgt gggcctgatg     1320

agcagagttg ctcagcctgc cagcaagaag atcgaccaga acaagctgaa gcccgagatg     1380

gacgagaagg gcaatctgac cacagccggc tttgcctgct ctcagtgtgg ccagcctctg     1440

ttcgtgtaca agctggaaca ggtgtccgag aaaggcaagg cctacaccaa ctacttcggc     1500

agatgtaacg tggccgagca cgagaagctg attctgctgg cccagctgaa acctgagaag     1560

gactctgatg aggccgtgac ctacagcctg ggcaagtttg gacagagagc cctggacttc     1620

tacagcatcc acgtgaccaa agaaagcaca caccccgtga agcccctggc tcagatcgcc     1680

ggcaatagat acgcctctgg acctgtgggc aaagccctgt ccgatgcctg catgggaaca     1740

atcgccagct tcctgagcaa gtaccaggac atcatcatcg agcaccagaa ggtggtcaag     1800

ggcaaccaga agagactgga aagcctgagg gagctggccg gcaaagagaa cctggaatac     1860

cccagcgtga ccctgcctcc tcagcctcac acaaaagaag gcgtggacgc ctacaacgaa     1920

gtgatcgcca gagtgagaat gtgggtcaac ctgaacctgt ggcagaagct gaaactgtcc     1980

agggacgacg ccaagcctct gctgagactg aagggcttcc ctagcttccc tctggtggaa     2040

agacaggcca atgaagtgga ttggtgggac atggtctgca acgtgaagaa gctgatcaac     2100

gagaagaaag aggatggcaa ggttttctgg cagaacctgg ccggctacaa gagacaagaa     2160

gccctgaggc cttacctgag cagcgaagag gaccggaaga agggcaagaa gttcgccaga     2220

taccagctgg gcgacctgct gctgcacctg gaaaagaagc acggcgagga ctggggcaaa     2280

gtgtacgatg aggcctggga gagaatcgac aagaaggtgg aaggcctgag caagcacatt     2340

aagctggaag aggaaagaag gagcgaggac gcccaatcta aagccgctct gaccgattgg     2400

ctgagagcca aggccagctt tgtgatcgag ggcctgaaag aggccgacaa ggacgagttc     2460

tgcagatgcg agctgaagct gcagaagtgg tacggcgatc tgagaggcaa gcccttcgcc     2520

attgaggccg agaacagcat cctggacatc agcggcttca gcaagcagta caactgcgcc     2580

ttcatttggc agaaagacgg cgtcaagaaa ctgaacctgt acctgatcat caattacttc     2640

aaaggcggca agctgcggtt caagaagatc aaacccgagg ccttcgaggc taacagattc     2700

tacaccgtga tcaacaaaaa gtccggcgag atcgtgccca tggaagtgaa cttcaacttc     2760

gacgacccca acctgattat cctgcctctg gccttcggca agagacaggg cagagagttc     2820

atctggaacg atctgctgag cctggaaacc ggctctctga agctggccaa tggcagagtg     2880

atcgagaaaa ccctgtacaa caggagaacc agacaggacg agcctgctct gtttgtggcc     2940

ctgaccttcg agagaagaga ggtgctggac agcagcaaca tcaagcccat gaacctgatc     3000

ggcgtggacc ggggcgagaa tatccctgct gtgatcgccc tgacagaccc tgaaggatgc     3060

ccactgagca gattcaagga ctccctgggc aaccctacac acatcctgag aatcggcgag     3120

agctacaaag agaagcagag gacaatccag gccaagaaag aggtggaaca gagaagagcc     3180

ggcggatact ctaggaagta cgccagcaag gccaagaatc tggccgacga catggtccga     3240

aacaccgcca gagatctgct gtactacgcc gtgacacagg acgccatgct gatcttcgag     3300

aatctgagca gaggcttcgg ccggcagggc aagagaacct ttatggccga gaggcagtac     3360

accagaatgg aagattggct cacagctaaa ctggcctacg agggactgag caagacctac     3420

ctgtccaaaa cactggccca gtatacctcc aagacctgca gcaattgcgg cttcaccatc     3480

accagcgccg actacgacag agtgctggaa aagctcaaga aaaccgccac cggctggatg     3540

accaccatca acggcaaaga gctgaaggtt gagggccaga tcacctacta caacaggtac     3600

aagaggcaga acgtcgtgaa ggatctgagc gtggaactgg acagactgag cgaagagagc     3660

gtgaacaacg acatcagcag ctggacaaag ggcagatcag gcgaggctct gagcctgctg     3720

aagaagaggt ttagccacag acctgtgcaa gagaagttcg tgtgcctgaa ctgcggcttc     3780

gagacacacg ccgatgaaca ggctgccctg aacattgcca gaagctggct gttcctgaga     3840

agccaagagt acaagaagta ccagaccaac aagaccaccg gcaacaccga caagagggcc     3900

tttgtggaaa cctggcagag cttctacaga aaaaagctga aagaagtctg gaagcccgcc     3960

gtgactagtc caaaaaagaa gagaaaggta gccctcgagt acccatatga tgtccctgac     4020

tacgcttga                                                             4029


<210>  915
<211>  4095
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP70 plasmid sequence

<400>  915
atgggtcaga ttttcagcag aagcgcctcc cctattccta gacctccacg gggcctggcc       60

gcccaccact ggctgaattt cctgcaggcc gcttatagac tggagcctgg accttccagc      120

tacgacttcc accagctgaa gaaattcctg aagatcgccc tggaaacccc tgccagaatc      180

tgccctatca actacagcct gctggcctcc ctgctgccca agggctaccc tggcagagtg      240

aacgagatcc ttcatatcct gatccagaca caggctcaga tcccctctag gcccgctcca      300

cctcctccaa gcagcccaac ccacgatcct cctgatagcg accctcagat ccccccacca      360

tacgtggagc ccaccgcccc tcaagtgctg ccagtgatgc acccccacgg cgcccctcct      420

aatcacagac cttggcagat gaaagacctg caggccatca agcaggaagt gtcccaggcc      480

gctcctggca gcccccaatt tatgcagacc atcagactcg ccgttcagca gttcgacccc      540

acagccaagg atctgcagga cctgctgcag tacctgtgta gcagcctggt cgccagcctg      600

caccatcagc aactggattc tctgatcagc gaggccgaga caagaggcat caccggctac      660

aaccctctgg ccggccccct gcgggtgcag gcaaacaacc cccagcagca ggggctgcgg      720

agagagtacc agcagctgtg gctggctgct ttcgccgcac tgcctggaag cgccaaagat      780

ccatcttggg cctctatcct gcagggcctg gaagaacctt accacgcctt tgtggaaaga      840

ctgaacatcg ccctggacaa cggcctgcct gagggcaccc ctaaggaccc catcctgaga      900

tctctggcct acagcaacgc caacaaggaa tgtcagaagc tgctgcaagc cagaggccac      960

accaacagcc ccctgggcga catgctgcgc gcctgccaga cctggacccc taaggacaag     1020

accaaggtgc tggtggtgca gcctaagaag cctcccccta atggcggcag cccaaagaag     1080

aagcggaagg tctctagaca agagatcaag agaatcaaca agatcagaag gagactggtc     1140

aaggacagca acacaaagaa ggccggcaag acaggcccca tgaaaaccct gctcgtcaga     1200

gtgatgaccc ctgacctgag agagcggctg gaaaacctga gaaagaagcc cgagaacatc     1260

cctcagccta tcagcaacac cagcagggcc aacctgaaca agctgctgac cgactacacc     1320

gagatgaaga aagccatcct gcacgtgtac tgggaagagt tccagaaaga ccccgtgggc     1380

ctgatgagca gagttgctca gcctgccagc aagaagatcg accagaacaa gctgaagccc     1440

gagatggacg agaagggcaa tctgaccaca gccggctttg cctgctctca gtgtggccag     1500

cctctgttcg tgtacaagct ggaacaggtg tccgagaaag gcaaggccta caccaactac     1560

ttcggcagat gtaacgtggc cgagcacgag aagctgattc tgctggccca gctgaaacct     1620

gagaaggact ctgatgaggc cgtgacctac agcctgggca agtttggaca gagagccctg     1680

gacttctaca gcatccacgt gaccaaagaa agcacacacc ccgtgaagcc cctggctcag     1740

atcgccggca atagatacgc ctctggacct gtgggcaaag ccctgtccga tgcctgcatg     1800

ggaacaatcg ccagcttcct gagcaagtac caggacatca tcatcgagca ccagaaggtg     1860

gtcaagggca accagaagag actggaaagc ctgagggagc tggccggcaa agagaacctg     1920

gaatacccca gcgtgaccct gcctcctcag cctcacacaa aagaaggcgt ggacgcctac     1980

aacgaagtga tcgccagagt gagaatgtgg gtcaacctga acctgtggca gaagctgaaa     2040

ctgtccaggg acgacgccaa gcctctgctg agactgaagg gcttccctag cttccctctg     2100

gtggaaagac aggccaatga agtggattgg tgggacatgg tctgcaacgt gaagaagctg     2160

atcaacgaga agaaagagga tggcaaggtt ttctggcaga acctggccgg ctacaagaga     2220

caagaagccc tgaggcctta cctgagcagc gaagaggacc ggaagaaggg caagaagttc     2280

gccagatacc agctgggcga cctgctgctg cacctggaaa agaagcacgg cgaggactgg     2340

ggcaaagtgt acgatgaggc ctgggagaga atcgacaaga aggtggaagg cctgagcaag     2400

cacattaagc tggaagagga aagaaggagc gaggacgccc aatctaaagc cgctctgacc     2460

gattggctga gagccaaggc cagctttgtg atcgagggcc tgaaagaggc cgacaaggac     2520

gagttctgca gatgcgagct gaagctgcag aagtggtacg gcgatctgag aggcaagccc     2580

ttcgccattg aggccgagaa cagcatcctg gacatcagcg gcttcagcaa gcagtacaac     2640

tgcgccttca tttggcagaa agacggcgtc aagaaactga acctgtacct gatcatcaat     2700

tacttcaaag gcggcaagct gcggttcaag aagatcaaac ccgaggcctt cgaggctaac     2760

agattctaca ccgtgatcaa caaaaagtcc ggcgagatcg tgcccatgga agtgaacttc     2820

aacttcgacg accccaacct gattatcctg cctctggcct tcggcaagag acagggcaga     2880

gagttcatct ggaacgatct gctgagcctg gaaaccggct ctctgaagct ggccaatggc     2940

agagtgatcg agaaaaccct gtacaacagg agaaccagac aggacgagcc tgctctgttt     3000

gtggccctga ccttcgagag aagagaggtg ctggacagca gcaacatcaa gcccatgaac     3060

ctgatcggcg tggaccgggg cgagaatatc cctgctgtga tcgccctgac agaccctgaa     3120

ggatgcccac tgagcagatt caaggactcc ctgggcaacc ctacacacat cctgagaatc     3180

ggcgagagct acaaagagaa gcagaggaca atccaggcca agaaagaggt ggaacagaga     3240

agagccggcg gatactctag gaagtacgcc agcaaggcca agaatctggc cgacgacatg     3300

gtccgaaaca ccgccagaga tctgctgtac tacgccgtga cacaggacgc catgctgatc     3360

ttcgagaatc tgagcagagg cttcggccgg cagggcaaga gaacctttat ggccgagagg     3420

cagtacacca gaatggaaga ttggctcaca gctaaactgg cctacgaggg actgagcaag     3480

acctacctgt ccaaaacact ggcccagtat acctccaaga cctgcagcaa ttgcggcttc     3540

accatcacca gcgccgacta cgacagagtg ctggaaaagc tcaagaaaac cgccaccggc     3600

tggatgacca ccatcaacgg caaagagctg aaggttgagg gccagatcac ctactacaac     3660

aggtacaaga ggcagaacgt cgtgaaggat ctgagcgtgg aactggacag actgagcgaa     3720

gagagcgtga acaacgacat cagcagctgg acaaagggca gatcaggcga ggctctgagc     3780

ctgctgaaga agaggtttag ccacagacct gtgcaagaga agttcgtgtg cctgaactgc     3840

ggcttcgaga cacacgccga tgaacaggct gccctgaaca ttgccagaag ctggctgttc     3900

ctgagaagcc aagagtacaa gaagtaccag accaacaaga ccaccggcaa caccgacaag     3960

agggcctttg tggaaacctg gcagagcttc tacagaaaaa agctgaaaga agtctggaag     4020

cccgccgtga ctagtccaaa aaagaagaga aaggtagccc tcgagtaccc atatgatgtc     4080

cctgactacg cttga                                                      4095


<210>  916
<211>  4434
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP71 plasmid sequence

<400>  916
atgggcaata gctcctctac cccccctcca agcgccctga agaactccga tctgttcaag       60

accatgctga ggacacagta cagcggctcc gtgaagacac ggagaatcaa ccaggatatc      120

aagaagcagt atccactgtg gccagaccag ggaacctgcg caacaaagca ctgggagcag      180

gccgtgctga tccccctgga ctctgtgagc gaggagaccg ccaaggtgct gaatttcctg      240

cgggtgaaga tccaggccag aaagggagag accgcaaggc agatgaccgc acacacaatc      300

aagaagctga tcgtgggcac aatcgataag aacaagcagc agaccgagat cctgcagaag      360

acagacgaga gcgatgagga gatggacacc acaaatacca tgctgtttat cgcccgcaac      420

aagagggaga ggatcgcaca gcagcagcag gcagatctgg cagcacagca gcaggtgctg      480

ctgctgcaga gggagcagca gagggagcag agagagaagg atatcaagaa gcgggacgag      540

aagaagaaga agctgctgcc cgacaccaca cagaaggtgg agcagaccga tatcggagag      600

gccagctcct ctgacgcctc cgcccagaag ccaatctcta ccgacaacaa tcccgatctg      660

aaggtggacg gcgtgctgac aagaagccag cacaccacag tgccttccaa catcaccatc      720

aagaaggatg gcacatccgt gcagtaccag caccccatca ggaactatcc taccggcgag      780

ggcaatctga cagcccaggt gcggaaccct tttagaccac tggagctgca gcagctgagg      840

aaggactgcc ccgccctgcc tgagggcatc ccacagctgg ccgagtggct gacccagaca      900

atggccatct acaattgtga cgaggccgat gtggagcagc tggccagagt gatcttccca      960

acccctgtga ggcagatcgc aggcgtgatc aacggacacg cagcagcaaa taccgcagcc     1020

aagatccaga actacgtgac agcatgcagg cagcactatc cagccgtgtg cgattggggc     1080

accatccagg cctttacata caagccccct cagaccgccc acgagtatgt gaagcacgcc     1140

gagatcatct tcaagaacaa tagcggactg gagtggcagc acgcaaccgt gccttttatc     1200

aatatggtgg tgcagggcct gccacccaag gtgacacggt ccctgatgtc tggcaaccca     1260

gattggagca ccaagacaat cccacagatc atccccctga tgcagcacta cctgaatctg     1320

cagtccagac aggacgccaa gatcaagcag acccctctgg tgctgcagct ggccatgcca     1380

gcccagacaa tgaacggcaa tggcggcagc ccaaagaaga agcggaaggt ctctagacaa     1440

gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag     1500

gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga     1560

gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc     1620

agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg     1680

cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag     1740

cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat     1800

ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg     1860

gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc     1920

gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc     1980

gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg     2040

accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc     2100

tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg     2160

agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga     2220

ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg     2280

cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg     2340

agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag     2400

cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     2460

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     2520

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     2580

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     2640

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     2700

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     2760

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     2820

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     2880

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     2940

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     3000

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     3060

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     3120

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     3180

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     3240

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     3300

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     3360

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     3420

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     3480

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     3540

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     3600

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     3660

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     3720

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     3780

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     3840

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     3900

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     3960

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     4020

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     4080

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     4140

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     4200

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     4260

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     4320

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa     4380

aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga           4434


<210>  917
<211>  4398
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP72 plasmid sequence

<400>  917
atgggccaga caatcacaac ccctctgagc ctgaccctgg accactggag tgaagtgcgg       60

gctagagccc acaaccaggg cgtggaagtc cggaaaaaaa agtggatcac cctgtgcgag      120

gccgagtggg tcatgatgaa cgtgggatgg cctagagagg gtacatttag cctggacaac      180

atcagccagg ttgagaaaaa gattttcgct cctggccctt acggccatcc tgaccaggtg      240

ccttacatca ccacatggcg gagcctggct accgacccac caagctgggt gcggcccttc      300

ctgcctcctc ccaagccccc cacccctctg cctcagcctc tgagccccca gccctctgcc      360

cctctgacca gctctctgta ccctgtgctg cctaagtccg atccccctaa acctcctgtt      420

ttacctcccg accctagcag cccactgatc gacctgctga cggaagaacc tcctccttat      480

cctggcggac atggcccccc accttctggc cctcggaccc caaccgcctc ccctatcgcc      540

tctagactga gagagcggag agaaaacccc gccgaagagt cccaagccct gcccctgaga      600

gagggcccta acaaccggcc tcagtactgg cccttcagcg ccagcgatct gtataactgg      660

aagtcccaca atcctccttt cagccaggat cctgtggccc tgacaaacct gatcgagtct      720

atcctggtga ctcaccagcc aacctgggat gactgccagc agctgctgca ggccctcctg      780

accggcgaag agagacagag agtgctgctg gaggccagaa agcaggtgcc tggagaggac      840

ggcaggccta cccagctgcc taatgtgatc gacgagacat tccccctgac cagaccaaat      900

tgggacttcg ccaccccagc tggcagagag cacctgcgcc tgtaccggca gcttctgctg      960

gccggactga gaggcgctgc cagaagacca accaacctgg ctcaggtgaa gcaggtcgtg     1020

cagggcaaag aggagacacc cgccgctttc ctggaacggc tgaaggaggc ctacagaatg     1080

tacacccctt acgaccccga agatccagga caggccgcca gcgtgatcct gagcttcatc     1140

taccagagca gccctgacat cagaaacaag ctgcagcggc tggaaggcct gcagggcttc     1200

acactgagcg acctgctcaa ggaggccgag aagatctaca acaagcggga aacccctgag     1260

gaaagagaag agagattgtg gcagcggcaa gaggagcggg acaaaaagcg gcacaaggaa     1320

atgaccaagg tgctggctac cgtggtggcc cagaacagag ataaaggcgg cagcccaaag     1380

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1440

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1500

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1560

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1620

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1680

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1740

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     1800

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     1860

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     1920

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     1980

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2040

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2100

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2160

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     2220

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2280

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2340

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2400

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2460

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2520

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2580

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2640

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2700

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     2760

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     2820

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     2880

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     2940

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3000

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3060

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3120

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3180

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3240

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3300

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3360

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3420

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3480

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3540

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3600

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3660

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3720

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     3780

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     3840

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     3900

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     3960

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4020

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4080

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4140

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4200

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4260

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4320

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4380

gtccctgact acgcttga                                                   4398


<210>  918
<211>  4497
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP73 plasmid sequence

<400>  918
atgggccaga ccgtgaccac acccctgtcc ctgacactgg gccactggaa ggacgtggag       60

cggatcgccc acaatcagtc tgtggatgtg aagaagcgga gatgggtgac cttctgcagc      120

gccgagtggc ccaccttcaa cgtgggctgg ccaagggacg gcaccttcaa ccgcgatctg      180

atcacacagg tgaagatcaa ggtgtttagc ccaggacctc acggacaccc agaccaggtg      240

ccttatatcg tgacctggga ggccctggcc ttcgatccac ctccatgggt gaagccattt      300

gtgcacccaa agccacctcc accactgcct ccatccgccc cttctctgcc actggagcca      360

cctcggtcca ccccaccaag aagctccctg tatcctgccc tgacaccatc tctgggcgcc      420

aagccaaagc cacaggtgct gtctgacagc ggaggacctc tgatcgacct gctgaccgag      480

gatcctccac cctacagaga tccaaggcct ccaccatccg acagggatgg aaacggagga      540

gaggcaacac cagcaggaga ggcccctgac ccatccccca tggcctctag actgaggggc      600

aggcgcgagc ctccagtggc agatagcacc acatcccagg cattcccact gagggcagga      660

ggaaatggcc agctgcagta ttggcccttt tctagctccg acctgtacaa ctggaagaac      720

aataacccat ccttctctga ggatcccggc aagctgaccg ccctgatcga gagcgtgctg      780

atcacccacc agcccacatg ggacgattgt cagcagctgc tgggcaccct gctgacaggc      840

gaggagaagc agcgggtgct gctggaggca aggaaggccg tgagaggcga cgatggcaga      900

cccacccagc tgcctaatga ggtggacgca gcatttccac tggagaggcc agactgggat      960

tataccacac aggccggcag gaaccacctg gtgcactaca ggcagctgct gctggccgga     1020

ctgcagaatg caggcaggtc ccctaccaac ctggccaagg tgaagggcat cacacagggc     1080

cctaatgaga gcccatccgc ctttctggag cgcctgaagg aggcctaccg gagatatacc     1140

ccctacgacc ctgaggatcc aggccaggag acaaacgtgt ctatgagctt catctggcag     1200

tctgccccag acatcggaag gaagctggag cgcctggagg acctgaagaa taagaccctg     1260

ggcgatctgg tgcgggaggc agagaagatc ttcaacaaga gagagacacc tgaggagagg     1320

gaggagcgga tcaggaggga gaccgaggag aaggaggagc ggagaaggac agaggacgag     1380

cagaaggaga aggagcggga tcgccggaga cacagagaga tgagcaagct gctggccacc     1440

gtggtgtccg gacagaagca ggacggcggc agcccaaaga agaagcggaa ggtctctaga     1500

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     1560

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     1620

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     1680

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     1740

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     1800

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     1860

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     1920

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     1980

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     2040

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     2100

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     2160

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     2220

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     2280

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     2340

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     2400

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     2460

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     2520

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     2580

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     2640

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     2700

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     2760

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     2820

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     2880

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     2940

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     3000

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     3060

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     3120

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     3180

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     3240

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     3300

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     3360

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     3420

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     3480

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     3540

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     3600

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     3660

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     3720

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     3780

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     3840

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     3900

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     3960

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     4020

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     4080

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     4140

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     4200

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     4260

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     4320

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     4380

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     4440

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        4497


<210>  919
<211>  4158
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP74 plasmid sequence

<400>  919
atggtgtctc tggacaggga tatggcaagg caggtgagcg gaggcaagag ggattaccca       60

gagctggaga agtgcatcaa gcacgcctgt aagatcaagg tgcggctgag aggagagcac      120

ctgaccgagg gcaactgcct gtggtgtctg aagacactgg actatatgtt cgaggatcac      180

aaggaggagc cctggaccaa ggtgaagttt agaacaatct ggcagaaggt gaagaacctg      240

acccctgagg agagcaataa gaaggacttc atgtccctgc aggccacact ggccggcctg      300

atgtgctgtc agatgggcat gaggccagag accctgcagg acgccatggc cacagtgatc      360

atgaaggatg gcctgctgga gcaggaggag aagaaggagg ataagcgcga gaaggaggag      420

agcgtgtttc caatcgtggt gcaggcagca ggaggccggt cctggaaggc cgtggactct      480

gtgatgttcc agcagctgca gaccgtggca atgcagcacg gactggtgag cgaggatttt      540

gagagacagc tggcctacta tgccaccaca tggacatcca aggacatcct ggaggtgctg      600

gccatgatgc ccggcaacag agcccagaag gagctgatcc agggcaagct gaatgaggag      660

gccgagaggt ggcggagaaa caatccacct ccaccagcag gaggaggact gaccgtggat      720

cagatcatgg gagtgggaca gacaaaccag gcagcagcac aggcaaatat ggaccaggcc      780

agacagatct gcctgcagtg ggtcatcaac gcactgaggg ccgtgagaca catggcacac      840

aggcccggca accctatgct ggtgaagcag aagaccaatg agccttacga ggacttcgcc      900

gccagactgc tggaggccat cgatgccgag ccagtgacac agcccatcaa ggactacctg      960

aagctgaccc tgagctatac aaatgcctcc gccgactgcc agaagcagat ggatagaacc     1020

ctgggacaga gggtgcagca ggcctccgtg gaggagaaga tgcaggcctg tagggatgtg     1080

ggctctgagg gctttaagat gcagctgctg gcccaggccc tgaggggcgg cagcccaaag     1140

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1200

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1260

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1320

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1380

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1440

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1500

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     1560

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     1620

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     1680

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     1740

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     1800

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     1860

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     1920

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     1980

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2040

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2100

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2160

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2220

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2280

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2340

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2400

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2460

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     2520

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     2580

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     2640

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     2700

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     2760

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     2820

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     2880

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     2940

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3000

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3060

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3120

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3180

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3240

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3300

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3360

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3420

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3480

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     3540

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     3600

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     3660

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     3720

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     3780

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     3840

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     3900

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     3960

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4020

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4080

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4140

gtccctgact acgcttga                                                   4158


<210>  920
<211>  4140
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP75 plasmid sequence

<400>  920
atgggcgatc ctctgacatg gagcaaggcc ctgaagaagc tggagaaggt gaccgtgcag       60

ggcagccaga agctgaccac aggcaactgc aattgggccc tgtccctggt ggacctgttc      120

cacgatacaa actttgtgaa ggagaaggat tggcagctgc gcgacgtgat cccactgctg      180

gaggacgtga cccagacact gtctggccag gagcgggagg ccttcgagag aacctggtgg      240

gccatcagcg ccgtgaagat gggcctgcag atcaacaatg tggtggatgg caaggcctct      300

tttcagctgc tgagggccaa gtacgagaag aagacagcca acaagaagca gtctgagcct      360

agcgaggagt atccaatcat gatcgacggc gccggcaacc ggaatttcag accactgacc      420

cccagaggct acaccacatg ggtgaacaca atccagacca acggcctgct gaatgaggcc      480

tcccagaatc tgttcggcat cctgagcgtg gattgtacct ccgaggagat gaatgccttt      540

ctggacgtgg tgccaggaca ggcaggacag aagcagatcc tgctggacgc catcgataag      600

atcgccgacg attgggataa ccggcaccca ctgcccaatg cacctctggt ggcaccacct      660

cagggaccta tcccaatgac agccaggttt atcaggggac tgggagtgcc acgggagaga      720

cagatggagc ccgccttcga ccagtttagg cagacctacc gccagtggat catcgaggcc      780

atgagcgagg gcatcaaagt gatgatcggc aagccaaagg cacagaacat caggcaggga      840

gccaaggagc cctatcctga gttcgtggat agactgctgt cccagatcaa gtctgagggc      900

caccctcagg agatctccaa gtttctgacc gacacactga ccatccagaa cgccaatgag      960

gagtgccgga atgccatgcg gcacctgaga ccagaggata ccctggagga gaagatgtac     1020

gcctgtagag acatcggcac cacaaagcag aagatgatgc tgctggccaa ggccctgcag     1080

acaggcctgg ccggaccatt caagggaggc ggcagcccaa agaagaagcg gaaggtctct     1140

agacaagaga tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca     1200

aagaaggccg gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac     1260

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc     1320

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc     1380

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt     1440

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag     1500

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac     1560

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac     1620

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat     1680

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc     1740

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga     1800

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc     1860

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag     1920

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg     1980

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc     2040

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac     2100

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     2160

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     2220

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     2280

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     2340

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     2400

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     2460

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     2520

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     2580

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     2640

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     2700

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     2760

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     2820

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     2880

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     2940

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     3000

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     3060

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     3120

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     3180

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     3240

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     3300

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     3360

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     3420

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     3480

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     3540

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     3600

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     3660

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     3720

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     3780

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     3840

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     3900

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     3960

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     4020

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt     4080

ccaaaaaaga agagaaaggt agccctcgag tacccatatg atgtccctga ctacgcttga     4140


<210>  921
<211>  4158
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP76 plasmid sequence

<400>  921
atgggcgcca ggaacagcgt gctgtccggc aaggaggccg atgagctgga gaaggtgcgg       60

ctgagaccca atggcaagaa gaagtacatg ctgaagcacg tggtgtgggc agcaaacgag      120

ctggaccgct tcggcctggc cgagtctctg ctggataata aggagggctg ccagaagatc      180

ctgagcgtgc tggcccctct ggtgccaacc ggctctgaga acctgaagag cctgtataat      240

acagtgtgcg tgatctggtg tatccacgcc gaggagaagg tgaagcacac cgaggaggcc      300

aagcagatcg tgcagaggca cctggtggtg gagaccggca cagcagatag gatgccagcc      360

accagccgcc caacagcacc accttccgga aggggcggca actaccccgt gcagcaagtg      420

ggcggcaatt atgtgcacct gcccctgagc cctagaaccc tgaacgcctg ggtgaagctg      480

gtggaggaga agaagttcgg agcagaggtg gtgccaggat ttcaggccct gtccgagggc      540

tgcacaccct acgacatcaa ccagatgctg aattgcgtgg gagagcacca ggcagcaatg      600

cagatcatcc gggagatcat caacgaggag gcagcagact gggatctgca gcaccctcag      660

ccaggaccac tgcctgcagg acagctgcgg gagcctagag gctctgacat cgccggcacc      720

acaagcaccg tggatgagca gatccagtgg atgtacaggc agcagaaccc aatccccgtg      780

ggcaatatct atcggagatg gatccagctg ggcctgcaga agtgcgtgcg gatgtataac      840

ccaaccaata tcctggacgt gaagcagggc ccaaaggagc ccttccagag ctacgtggac      900

agattctaca agtccctgag agccgagcag acagatcccg ccgtgaagaa ctggatgacc      960

cagacactgc tgatccagaa cgccaatccc gattgcaagc tggtgctgaa gggcctgggc     1020

atgaatccta ccctggagga gatgctgaca gcatgtcagg gagtgggagg acctggacag     1080

aaggcaaggc tgatggcaga ggccctgaag gaggccctga ggcctggcgg cagcccaaag     1140

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1200

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1260

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1320

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1380

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1440

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1500

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     1560

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     1620

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     1680

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     1740

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     1800

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     1860

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     1920

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     1980

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2040

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2100

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2160

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2220

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2280

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2340

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2400

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2460

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     2520

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     2580

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     2640

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     2700

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     2760

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     2820

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     2880

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     2940

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3000

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3060

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3120

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3180

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3240

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3300

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3360

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3420

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3480

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     3540

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     3600

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     3660

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     3720

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     3780

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     3840

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     3900

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     3960

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4020

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4080

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4140

gtccctgact acgcttga                                                   4158


<210>  922
<211>  4152
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP77 plasmid sequence

<400>  922
atggccaagc agggctccaa ggagaagaag ggctaccccg agctgaagga agtgatcaag       60

gcaacctgca agatcagggt gggacctggc aaggagaccc tgacagaggg caactgtctg      120

tgggccctga agacaatcga cttcatcttt gaggatctga agaccgagcc atggaccatc      180

acaaagatgt atacagtgtg ggatcggctg aagggactga ccccagagga gacatccaag      240

agagagttcg cctctctgca ggccaccctg gcctgcatca tgtgctccca gatgggcatg      300

aagcctgaga cagtgcaggc cgccaagggc atcatctcta tgaaggaggg cctgcacgag      360

aataaggagg ccaagggcga gaaggtggag cagctgtacc ctaacctgga gaagcacagg      420

gaggtgtatc caatcgtgaa tctgcaggca ggaggccgca gctggaaggc agtggagtcc      480

gtggtgttcc agcagctgca gaccgtggcc atgcagcacg gcctggtgtc tgaggacttt      540

gagcggcagc tggcctacta tgccaccaca tggacaagca aggatatcct ggaggtgctg      600

gccatgatgc caggcaacag agcccagaag gagctgatcc agggcaagct gaatgaggag      660

gcagagcggt gggtgagaca gaacccacct ggacccaatg tgctgaccgt ggaccagatc      720

atgggcgtgg gccagacaaa ccagcaggcc agccaggcca atatggatca ggccaggcag      780

atctgcctgc agtgggtcat caccgccctg aggagcgtgc gccacatgtc ccacaggcct      840

ggaaacccaa tgctggtgaa gcagaagaat acagagtcct acgaggactt catcgccagg      900

ctgctggagg caatcgacgc agagcccgtg acagatccta tcaagaccta cctgaaggtg      960

accctgtctt atacaaacgc cagcaccgac tgccagaagc agatggatag gaccctggga     1020

acacgcgtgc agcaggcaac cgtggaggag aagatgcagg cctgtcggga tgtgggctct     1080

gagggcttta agatgcagct gctggcccag gccctgagag gcggcagccc aaagaagaag     1140

cggaaggtct ctagacaaga gatcaagaga atcaacaaga tcagaaggag actggtcaag     1200

gacagcaaca caaagaaggc cggcaagaca ggccccatga aaaccctgct cgtcagagtg     1260

atgacccctg acctgagaga gcggctggaa aacctgagaa agaagcccga gaacatccct     1320

cagcctatca gcaacaccag cagggccaac ctgaacaagc tgctgaccga ctacaccgag     1380

atgaagaaag ccatcctgca cgtgtactgg gaagagttcc agaaagaccc cgtgggcctg     1440

atgagcagag ttgctcagcc tgccagcaag aagatcgacc agaacaagct gaagcccgag     1500

atggacgaga agggcaatct gaccacagcc ggctttgcct gctctcagtg tggccagcct     1560

ctgttcgtgt acaagctgga acaggtgtcc gagaaaggca aggcctacac caactacttc     1620

ggcagatgta acgtggccga gcacgagaag ctgattctgc tggcccagct gaaacctgag     1680

aaggactctg atgaggccgt gacctacagc ctgggcaagt ttggacagag agccctggac     1740

ttctacagca tccacgtgac caaagaaagc acacaccccg tgaagcccct ggctcagatc     1800

gccggcaata gatacgcctc tggacctgtg ggcaaagccc tgtccgatgc ctgcatggga     1860

acaatcgcca gcttcctgag caagtaccag gacatcatca tcgagcacca gaaggtggtc     1920

aagggcaacc agaagagact ggaaagcctg agggagctgg ccggcaaaga gaacctggaa     1980

taccccagcg tgaccctgcc tcctcagcct cacacaaaag aaggcgtgga cgcctacaac     2040

gaagtgatcg ccagagtgag aatgtgggtc aacctgaacc tgtggcagaa gctgaaactg     2100

tccagggacg acgccaagcc tctgctgaga ctgaagggct tccctagctt ccctctggtg     2160

gaaagacagg ccaatgaagt ggattggtgg gacatggtct gcaacgtgaa gaagctgatc     2220

aacgagaaga aagaggatgg caaggttttc tggcagaacc tggccggcta caagagacaa     2280

gaagccctga ggccttacct gagcagcgaa gaggaccgga agaagggcaa gaagttcgcc     2340

agataccagc tgggcgacct gctgctgcac ctggaaaaga agcacggcga ggactggggc     2400

aaagtgtacg atgaggcctg ggagagaatc gacaagaagg tggaaggcct gagcaagcac     2460

attaagctgg aagaggaaag aaggagcgag gacgcccaat ctaaagccgc tctgaccgat     2520

tggctgagag ccaaggccag ctttgtgatc gagggcctga aagaggccga caaggacgag     2580

ttctgcagat gcgagctgaa gctgcagaag tggtacggcg atctgagagg caagcccttc     2640

gccattgagg ccgagaacag catcctggac atcagcggct tcagcaagca gtacaactgc     2700

gccttcattt ggcagaaaga cggcgtcaag aaactgaacc tgtacctgat catcaattac     2760

ttcaaaggcg gcaagctgcg gttcaagaag atcaaacccg aggccttcga ggctaacaga     2820

ttctacaccg tgatcaacaa aaagtccggc gagatcgtgc ccatggaagt gaacttcaac     2880

ttcgacgacc ccaacctgat tatcctgcct ctggccttcg gcaagagaca gggcagagag     2940

ttcatctgga acgatctgct gagcctggaa accggctctc tgaagctggc caatggcaga     3000

gtgatcgaga aaaccctgta caacaggaga accagacagg acgagcctgc tctgtttgtg     3060

gccctgacct tcgagagaag agaggtgctg gacagcagca acatcaagcc catgaacctg     3120

atcggcgtgg accggggcga gaatatccct gctgtgatcg ccctgacaga ccctgaagga     3180

tgcccactga gcagattcaa ggactccctg ggcaacccta cacacatcct gagaatcggc     3240

gagagctaca aagagaagca gaggacaatc caggccaaga aagaggtgga acagagaaga     3300

gccggcggat actctaggaa gtacgccagc aaggccaaga atctggccga cgacatggtc     3360

cgaaacaccg ccagagatct gctgtactac gccgtgacac aggacgccat gctgatcttc     3420

gagaatctga gcagaggctt cggccggcag ggcaagagaa cctttatggc cgagaggcag     3480

tacaccagaa tggaagattg gctcacagct aaactggcct acgagggact gagcaagacc     3540

tacctgtcca aaacactggc ccagtatacc tccaagacct gcagcaattg cggcttcacc     3600

atcaccagcg ccgactacga cagagtgctg gaaaagctca agaaaaccgc caccggctgg     3660

atgaccacca tcaacggcaa agagctgaag gttgagggcc agatcaccta ctacaacagg     3720

tacaagaggc agaacgtcgt gaaggatctg agcgtggaac tggacagact gagcgaagag     3780

agcgtgaaca acgacatcag cagctggaca aagggcagat caggcgaggc tctgagcctg     3840

ctgaagaaga ggtttagcca cagacctgtg caagagaagt tcgtgtgcct gaactgcggc     3900

ttcgagacac acgccgatga acaggctgcc ctgaacattg ccagaagctg gctgttcctg     3960

agaagccaag agtacaagaa gtaccagacc aacaagacca ccggcaacac cgacaagagg     4020

gcctttgtgg aaacctggca gagcttctac agaaaaaagc tgaaagaagt ctggaagccc     4080

gccgtgacta gtccaaaaaa gaagagaaag gtagccctcg agtacccata tgatgtccct     4140

gactacgctt ga                                                         4152


<210>  923
<211>  4638
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP85 plasmid sequence

<400>  923
atggggcaag aattaagcca gcatgaacgt tatgtagaac aattgaagca ggctttaaag       60

acacggggag taaaggttaa atatgctgat cttttgaaat tttttgattt tgtgaaggat      120

acttgtcctt ggtttccgca agagggaacc atagatatta aacggtggcg tagagtaggc      180

gactgtttcc aagactatta caatactttt ggcccggaga aagtcccagt aactgcattc      240

tcttactgga acttaattaa agaattgata gataagaaag aagttaaccc acaagtaatg      300

gctgccgtag cccaaactga agaaatttta aaaagtaatt ctcaaacaga cctcacaaag      360

acctctcaaa acccagactt ggaccttatt tcccttgata gcgacgatga aggagctaaa      420

agttcctctc tacaagataa aggtttatca agtactaaaa aaccaaaaag attcccagtt      480

ctgttaacag cacaaactag taaagaccct gaagacccca acccctcaga ggtagactgg      540

gacggcttgg aagatgaggc agcgaaatat cataatcccg attggcctcc cttcctaacc      600

cgtccacctc cttacaataa agctactcct tccgcaccca ctgtaatggc ggttgttaat      660

ccaaaagagg agctcaaaga aaaaattgct caattagagg aacagattaa attagaagag      720

ttacaccagg cactaatttc caaattacaa aaactaaaaa cagggaatga aactgtaact      780

cacccagaca cagcaggagg cctttctcgc acgcctcact ggccagggca acatatccct      840

aaaggaaaat gttgcgccag tcgagaaaag gaagaacaaa tcccaaaaga tattttccca      900

gtgactgaaa ccgttgatgg gcaaggtcaa gcctggagac accataatgg ttttgatttt      960

gccgtcataa aagaattaaa aacagctgct tcccaatatg gggctactgc cccatacaca     1020

ttagccatag tggaatctgt agcggacaat tggcttaccc ctacagattg gaatacgctt     1080

gttagggcag tcctctcagg aggagatcac ttactgtgga aatctgagtt ttttgaaaat     1140

tgcagagata cggctaaaag aaaccaacaa gccggtaatg gctgggattt tgacatgtta     1200

acaggttcgg gtaattattc cagcaccgat gcacaaatgc agtatgatcc aggattgttt     1260

gctcaaattc aagcggctgc tacaaaagcc tggagaaaac ttcccgttaa gggagaccca     1320

ggagcctccc ttacaggagt caaacaagga cccgatgagc catttgcaga tttcgtacac     1380

agacttataa caactgctgg gagaatcttt ggaagtgctg aggccggtgt agactatgta     1440

aaacaactag catatgaaaa tgctaatcca gcttgtcagg cagccattcg cccctataga     1500

aagaagacag atttaactgg ctatatccgt ctttgctcgg atattgggcc ctcttatcag     1560

caaggcctgg ccatggccgc cgcctttagc gggcagactg taaaaggcgg cagcccaaag     1620

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1680

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1740

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1800

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1860

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1920

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1980

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     2040

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     2100

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     2160

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     2220

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2280

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2340

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2400

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     2460

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2520

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2580

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2640

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2700

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2760

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2820

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2880

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2940

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     3000

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     3060

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     3120

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     3180

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3240

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3300

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3360

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3420

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3480

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3540

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3600

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3660

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3720

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3780

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3840

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3900

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3960

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     4020

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     4080

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     4140

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     4200

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4260

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4320

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4380

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4440

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4500

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4560

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4620

gtccctgact acgcttga                                                   4638


<210>  924
<211>  4095
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP86 plasmid sequence

<400>  924
atgggccaaa tcttttcccg tagcgctagc cctattccgc gaccgccccg ggggctggcc       60

gctcatcact ggcttaactt cctccaggcg gcatatcgcc tagaacccgg tccctccaat      120

tgcgctttcc acctgttaag aagatatcat gaaacagttt ccggaatacc ggctcggatc      180

tgtcccatta actactccct cctagccagc ctactcccaa aaggataccc cggccgggtg      240

aatgaaattt tacacatact catccaaacc caagcccaga tcccgtcccg tcccgcgcca      300

ccgccgccgt catcccccac ccacgacccc ccggattctg atccacaaat cccccctccc      360

tatgttgagc ctacggcccc ccaagtcctt ccagtcatgc atccacatgg tgctcctcct      420

aaccatcgcc catggcaaat gaaagaccta caggccatta agcaagaagt ctcccaagca      480

gcccctggga gcccccagtt tatgcagacc atccggcttg cggtgcagca gtttgacccc      540

actgccaaag acctccaaga cctcctgcag tacctttgct cctccctcgt ggcttccctc      600

catcaccagc agctagatag ccttatatca gaggccgaaa cccgaggtat tacaggttat      660

aacccattag ccggtcccct ccgtgtccaa gccaacaatc cacaacaaca aggattaagg      720

cgagaatacc agcaactctg gctcgccgcc ttcgccgccc tgccggggag tgccaaagac      780

ccttcctggg cctctatcct ccaaggcctg gaggagcctt accacgcctt cgtagaacgc      840

ctcaacatag ctcttgacaa tgggctgcca gaaggcacgc ccaaagaccc catcttacgt      900

tccttagcct actccaatgc aaacaaagaa tgccaaaaat tactacaggc ccgaggacac      960

actaatagcc ctctaggaga tatgttgcgg gcttgtcaga cctggacccc caaagacaaa     1020

accaaagtgt tagttgtcca gcctaaaaaa ccccccccaa atggcggcag cccaaagaag     1080

aagcggaagg tctctagaca agagatcaag agaatcaaca agatcagaag gagactggtc     1140

aaggacagca acacaaagaa ggccggcaag acaggcccca tgaaaaccct gctcgtcaga     1200

gtgatgaccc ctgacctgag agagcggctg gaaaacctga gaaagaagcc cgagaacatc     1260

cctcagccta tcagcaacac cagcagggcc aacctgaaca agctgctgac cgactacacc     1320

gagatgaaga aagccatcct gcacgtgtac tgggaagagt tccagaaaga ccccgtgggc     1380

ctgatgagca gagttgctca gcctgccagc aagaagatcg accagaacaa gctgaagccc     1440

gagatggacg agaagggcaa tctgaccaca gccggctttg cctgctctca gtgtggccag     1500

cctctgttcg tgtacaagct ggaacaggtg tccgagaaag gcaaggccta caccaactac     1560

ttcggcagat gtaacgtggc cgagcacgag aagctgattc tgctggccca gctgaaacct     1620

gagaaggact ctgatgaggc cgtgacctac agcctgggca agtttggaca gagagccctg     1680

gacttctaca gcatccacgt gaccaaagaa agcacacacc ccgtgaagcc cctggctcag     1740

atcgccggca atagatacgc ctctggacct gtgggcaaag ccctgtccga tgcctgcatg     1800

ggaacaatcg ccagcttcct gagcaagtac caggacatca tcatcgagca ccagaaggtg     1860

gtcaagggca accagaagag actggaaagc ctgagggagc tggccggcaa agagaacctg     1920

gaatacccca gcgtgaccct gcctcctcag cctcacacaa aagaaggcgt ggacgcctac     1980

aacgaagtga tcgccagagt gagaatgtgg gtcaacctga acctgtggca gaagctgaaa     2040

ctgtccaggg acgacgccaa gcctctgctg agactgaagg gcttccctag cttccctctg     2100

gtggaaagac aggccaatga agtggattgg tgggacatgg tctgcaacgt gaagaagctg     2160

atcaacgaga agaaagagga tggcaaggtt ttctggcaga acctggccgg ctacaagaga     2220

caagaagccc tgaggcctta cctgagcagc gaagaggacc ggaagaaggg caagaagttc     2280

gccagatacc agctgggcga cctgctgctg cacctggaaa agaagcacgg cgaggactgg     2340

ggcaaagtgt acgatgaggc ctgggagaga atcgacaaga aggtggaagg cctgagcaag     2400

cacattaagc tggaagagga aagaaggagc gaggacgccc aatctaaagc cgctctgacc     2460

gattggctga gagccaaggc cagctttgtg atcgagggcc tgaaagaggc cgacaaggac     2520

gagttctgca gatgcgagct gaagctgcag aagtggtacg gcgatctgag aggcaagccc     2580

ttcgccattg aggccgagaa cagcatcctg gacatcagcg gcttcagcaa gcagtacaac     2640

tgcgccttca tttggcagaa agacggcgtc aagaaactga acctgtacct gatcatcaat     2700

tacttcaaag gcggcaagct gcggttcaag aagatcaaac ccgaggcctt cgaggctaac     2760

agattctaca ccgtgatcaa caaaaagtcc ggcgagatcg tgcccatgga agtgaacttc     2820

aacttcgacg accccaacct gattatcctg cctctggcct tcggcaagag acagggcaga     2880

gagttcatct ggaacgatct gctgagcctg gaaaccggct ctctgaagct ggccaatggc     2940

agagtgatcg agaaaaccct gtacaacagg agaaccagac aggacgagcc tgctctgttt     3000

gtggccctga ccttcgagag aagagaggtg ctggacagca gcaacatcaa gcccatgaac     3060

ctgatcggcg tggaccgggg cgagaatatc cctgctgtga tcgccctgac agaccctgaa     3120

ggatgcccac tgagcagatt caaggactcc ctgggcaacc ctacacacat cctgagaatc     3180

ggcgagagct acaaagagaa gcagaggaca atccaggcca agaaagaggt ggaacagaga     3240

agagccggcg gatactctag gaagtacgcc agcaaggcca agaatctggc cgacgacatg     3300

gtccgaaaca ccgccagaga tctgctgtac tacgccgtga cacaggacgc catgctgatc     3360

ttcgagaatc tgagcagagg cttcggccgg cagggcaaga gaacctttat ggccgagagg     3420

cagtacacca gaatggaaga ttggctcaca gctaaactgg cctacgaggg actgagcaag     3480

acctacctgt ccaaaacact ggcccagtat acctccaaga cctgcagcaa ttgcggcttc     3540

accatcacca gcgccgacta cgacagagtg ctggaaaagc tcaagaaaac cgccaccggc     3600

tggatgacca ccatcaacgg caaagagctg aaggttgagg gccagatcac ctactacaac     3660

aggtacaaga ggcagaacgt cgtgaaggat ctgagcgtgg aactggacag actgagcgaa     3720

gagagcgtga acaacgacat cagcagctgg acaaagggca gatcaggcga ggctctgagc     3780

ctgctgaaga agaggtttag ccacagacct gtgcaagaga agttcgtgtg cctgaactgc     3840

ggcttcgaga cacacgccga tgaacaggct gccctgaaca ttgccagaag ctggctgttc     3900

ctgagaagcc aagagtacaa gaagtaccag accaacaaga ccaccggcaa caccgacaag     3960

agggcctttg tggaaacctg gcagagcttc tacagaaaaa agctgaaaga agtctggaag     4020

cccgccgtga ctagtccaaa aaagaagaga aaggtagccc tcgagtaccc atatgatgtc     4080

cctgactacg cttga                                                      4095


<210>  925
<211>  4158
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP87 plasmid sequence

<400>  925
atgggcgcga gaaactccgt cttgtcaggg aaggaagcag atgaattaga aaaagttagg       60

ttacggccca acggaaagaa aaagtatatg ttgaagcatg tagtatgggc agcaaatgaa      120

ttggacagat ttggattagc agaaagcctg ttggataaca aagaaggttg tcaaaaaatt      180

ctttcagttt tagctccatt agttccgaca ggttcagaaa acttaaagag cctttataat      240

actgtctgcg tcatttggtg cattcacgca gaagagaaag tgaaacatac tgaggaagca      300

aaacaaatag tgcagagaca tctagtggtg gaaacaggaa cagcagacag aatgccagca      360

acaagcagac caacagcacc acctagtggc agaggaggaa attacccagt gcagcaagta      420

ggtggcaatt atgtccacct acccttaagt ccaagaacat taaatgcttg ggtaaaatta      480

gtagaagaga aaaaatttgg ggcagaggta gtgccaggat ttcaagcgct atcagaaggc      540

tgcactccct atgatattaa tcaaatgcta aattgtgtag gagaacatca ggcagccatg      600

caaattatta gagagattat aaatgaagaa gctgccgatt gggatttaca acacccgcaa      660

ccaggtccac taccagcagg gcaacttaga gagccaagag gatcagacat tgcaggaact      720

actagtacag tagatgaaca aatccaatgg atgtacaggc aacaaaaccc cataccagta      780

ggcaacattt atagaaggtg gatccaatta gggctgcaga aatgtgtaag aatgtataac      840

ccaacaaaca ttttagatgt gaaacaagga ccaaaagagc catttcaaag ctacgtagat      900

agattctaca aaagtctaag agcagagcaa acagatcccg cagtaaagaa ttggatgacc      960

caaacactgc tgattcaaaa tgctaaccca gattgtaaac tagtgctcaa gggtctgggc     1020

atgaatccca ctttagaaga aatgctgaca gcctgtcagg gagtaggagg gccaggacaa     1080

aaagctaggt taatggcaga agcattgaaa gaggcactga ggccaggcgg cagcccaaag     1140

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1200

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1260

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1320

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1380

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1440

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     1500

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     1560

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     1620

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     1680

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     1740

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     1800

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     1860

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     1920

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     1980

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2040

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2100

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2160

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2220

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2280

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2340

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2400

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     2460

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     2520

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     2580

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     2640

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     2700

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     2760

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     2820

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     2880

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     2940

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3000

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3060

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3120

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3180

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3240

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3300

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3360

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3420

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     3480

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     3540

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     3600

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     3660

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     3720

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     3780

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     3840

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     3900

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     3960

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4020

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4080

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4140

gtccctgact acgcttga                                                   4158


<210>  926
<211>  5140
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP57 plasmid sequence

<400>  926
atggcccaga acgagacatt tgatcctgtg gccctgcagg gctactaccc tgctggcggc       60

atcctggccg acaatgacat tatcaacatc agattcacca gcggacagtg gggcatcggc      120

gatagatggc tgcaggtgcg gctgagactg gtggacccta atactggaca gcctctggct      180

cagcctgagt acgaggacac aggcctgcct gccgaaaaca ggggtatcgt ggtggccgtg      240

tcccacaacg ccgccagaaa tatcttcaac aacgtgcagc cagctggtgg ccccaacaga      300

cacggccctc tgcacgacgg ccaatttcaa gtgggcgacg atcccagcga gcacttcgtg      360

cctattgagg aaaacctgat cccccaggag atcgtgaacc tgggagcagc tagaagagaa      420

gtgcggctgc tgagagaaat gtgcgtgcgg ctgctgcacg tgagaagaca gatgatgggc      480

atgggcatgc ctggcgctat ccagcctcaa ccgccagtgg gccccctgcc cgcccctgcc      540

cagcccccta tccctggccc acctgtgcct ccccccgtgc ctccccccgc ccctccagcc      600

cctgtcaacc cccctgtccc tccagtgcag cctatccacc acctgcctat tacccacatc      660

cgggccgtga tcggcgagac acctgcccag atcagagatg tgcccctgtg gctggcccag      720

tccatccctg ccctgaccgg cgtttatcct gccatggacg ccggaacact gacaagactg      780

gtgaacgcga tcaccgccag acaccccgga ctcgctcttg gcatgaacga ggccggctcc      840

tggcacgagg ccgttcatct gatctggcag aggaccttcg gcgctacagc cctccatgcc      900

ttgtctgatg tgctgaaggg catcgcccag cggaacggcg tggtgatggc cctggaaatg      960

ggcctgatgt tcaccaacga cgactgggac ctgacctggt ctgtgatccg gagatgtctg     1020

cctggacaag ccagcgttgt gaccatccag gcccggctgg atgccctgcc aaacaaccag     1080

gccaggatca tccaggccgg ctttatcatc agagaggtgt acgaggtgct gggcctggac     1140

ccactgggcc ggccactgaa cttccctgga ggcctgaccc agcgagacac cgccgtgccc     1200

gtgaccagag gccggggccg cggaagaacc ggccctagaa gaggccctgt gctgcctgtc     1260

agcagcaacc agcgccggca agaaaccgca ggcggcaacc agcctcagac ccaaccccag     1320

cagcagaaca cattcagcaa tcagacaaat cagagaggaa accagcggca gtggcaaaat     1380

agaggaaccg acagccagag acggtacttc ttcagaccca gaccaagcca gcctcagcgg     1440

tacggcagca accagggccc tgacaaccct aatccctaca gaggaagaga tagcaccaat     1500

caaagcggcc aggagcggca gctgcctcag cagcaacagg gctctagaag gggccctggc     1560

agaaacacaa acagcggcaa caacaccgtg cacaccgtgc ggcaagtgga atcttctcag     1620

ctacaacaaa atgcaagccc tacagcctct ccaagtacaa atcaagggca acagccttaa     1680

gggattttat gataccggcg ccgagatcac ctgcgtgcca gccatcttcc tgatcgagga     1740

agagcctatc ggcgagcgga ccatccaaac aatccacggc atcacaaagg aaaaggtgta     1800

ctacctgacc tttaagatcc agggcagaaa gctggccgct gaagtgattg gaacccagct     1860

ggactacgtg atcatcgccc ctagcgacat cccctggtac aagaaatacg agctggaact     1920

gacaattaaa atcgacatcc agaaacagca ggagcagctg ctgcacacca ccaacctctc     1980

tagcgaggga aagaagtacc tgaaggacct gttcatcaag tatgataatc tgtggcagaa     2040

gtgggaaaac caggtcggcc acagaagagg tgccaacacc gtgcacaccg tgcggcaagt     2100

ggaatctggc ggcagcccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat     2160

caacaagatc agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg     2220

ccccatgaaa accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa     2280

cctgagaaag aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct     2340

gaacaagctg ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga     2400

agagttccag aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa     2460

gatcgaccag aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg     2520

ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga     2580

gaaaggcaag gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct     2640

gattctgctg gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct     2700

gggcaagttt ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac     2760

acaccccgtg aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg     2820

caaagccctg tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga     2880

catcatcatc gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag     2940

ggagctggcc ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca     3000

cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa     3060

cctgaacctg tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact     3120

gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga     3180

catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg     3240

gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga     3300

ggaccggaag aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct     3360

ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga     3420

caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga     3480

cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga     3540

gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg     3600

gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat     3660

cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa     3720

actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat     3780

caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga     3840

gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct     3900

ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac     3960

cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac     4020

cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga     4080

cagcagcaac atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc     4140

tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg     4200

caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca     4260

ggccaagaaa gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa     4320

ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc     4380

cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg     4440

caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa     4500

actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc     4560

caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga     4620

aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt     4680

tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag     4740

cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa     4800

gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca     4860

agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct     4920

gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa     4980

caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag     5040

aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt     5100

agccctcgag tacccatatg atgtccctga ctacgcttga                           5140


<210>  927
<211>  4996
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP58 plasmid sequence

<400>  927
atggcccggg aactgaaccc cctgcagctg caacagctgt acatcaacaa tggcctgcag       60

cccaatcccg gccacggaga tatcatcgca gttagattca caggcggccc ttggggcccc      120

ggagatagat gggccagagt gaccatccgg ctgcaggaca acaccggcca gcctctgcaa      180

gtgcccggat acgacctgga gcctggcatc atcaatctgc gggaagatat cctgatcgcc      240

ggcccataca acctcatcag aacagctttt ctggacctgg aacctgccag aggaccagag      300

cggcacggcc cgttcggcga cggcagactg cagcctggcg atggactgag cgagggattt      360

cagcctatca ccgacgagga aatccaggct gaagtgggca ccatcggcgc cgcccgtaac      420

gagatccggc tgctgagaga agccttgcag agactccagg ctggcggtgt tggacggcct      480

atccctgggg ccgtgctgca gcctcaacct gtgatcggac ctgtgatccc catcaaccac      540

ctgagaagcg tgattggcaa cacacctcct aaccccagag atgtggccct gtggttgggc      600

agatctacag ccgctatcga gggcgtgttc cccatcgtgg accaggtgac ccggatgaga      660

gtggtgaacg ccctggtcgc ctctcatcct ggcctgaccc tgacagagaa cgaggccggc      720

agctggaacg ccgccatcag cgccctgtgg cggaaggccc acggcgctgc tgctcagcac      780

gagctggccg gagtgctgag cgacatcaac aagaaggaag gcatccagac agccttcaac      840

ctgggcatgc agttcaccga tggcaattgg tccctggtgt ggggaatcat caggaccctg      900

ctgcccggcc aggccctggt cacaaacgcc cagagccagt tcgacctgat gggcgacgac      960

attcagcggg ccgagaactt ccccagagtg attaacaacc tgtacaccat gctgggcctg     1020

aacatccacg gccagagcat cagacctaga gtgcagaccc agcctctgca gaccagacct     1080

cggaaccctg gcagaagcca gcagggtcag ctgaatcagc ctcggcctca gaacagagcc     1140

aaccagtcct acagaccccc tcggcagcag caacaacaca gcgacgtgcc tgagcagagg     1200

gaccagagag gcccatctca accgcctaga ggctctggcg gaggctataa cttcagaaga     1260

aatccccagc agcctcagcg gtacggccaa ggcccccccg gcccaaaccc ttacagacgg     1320

ttcggcgacg gcggcaatcc ccagcagcaa ggcccgcctc caaatagagg ccctgatcag     1380

ggacctagac caggcggcaa ccctcgcggc ggcggcaggg ggcagggccc ccggaacggc     1440

ggaggcagcg ccgccgccgt gcacaccgtg aaagccagcg aaaacgaaac taaaaatgga     1500

tctgctgaag ccgttgacgg tggaaagaaa gggggtaaag attaaaggtt actgggattc     1560

tcaggccgac atcacctgcg tgccaaagga cctgctgcag ggcgaggaac ccgtgcggca     1620

gcagaatgtg accaccatcc acggcaccca ggagggcgat gtctactacg tgaacctgaa     1680

gatcgacggc agaagaatca acaccgaggt gatcggcaca acactggact atgctatcat     1740

cacccctggc gacgtgcctt ggatcctgaa gaaacctctg gaactgacaa ttaagctgga     1800

tctggaagag caacaaggaa ccctgctcaa caacagcatc ctgagcaaga agggcaagga     1860

agagctgaaa cagctgttcg agaagtactc cgccctgtgg cagagctggg agaaccaggt     1920

gggacacaga cggggtgccg ccgccgtgca caccgtgaaa gccggcggca gcccaaagaa     1980

gaagcggaag gtctctagac aagagatcaa gagaatcaac aagatcagaa ggagactggt     2040

caaggacagc aacacaaaga aggccggcaa gacaggcccc atgaaaaccc tgctcgtcag     2100

agtgatgacc cctgacctga gagagcggct ggaaaacctg agaaagaagc ccgagaacat     2160

ccctcagcct atcagcaaca ccagcagggc caacctgaac aagctgctga ccgactacac     2220

cgagatgaag aaagccatcc tgcacgtgta ctgggaagag ttccagaaag accccgtggg     2280

cctgatgagc agagttgctc agcctgccag caagaagatc gaccagaaca agctgaagcc     2340

cgagatggac gagaagggca atctgaccac agccggcttt gcctgctctc agtgtggcca     2400

gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa ggcaaggcct acaccaacta     2460

cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt ctgctggccc agctgaaacc     2520

tgagaaggac tctgatgagg ccgtgaccta cagcctgggc aagtttggac agagagccct     2580

ggacttctac agcatccacg tgaccaaaga aagcacacac cccgtgaagc ccctggctca     2640

gatcgccggc aatagatacg cctctggacc tgtgggcaaa gccctgtccg atgcctgcat     2700

gggaacaatc gccagcttcc tgagcaagta ccaggacatc atcatcgagc accagaaggt     2760

ggtcaagggc aaccagaaga gactggaaag cctgagggag ctggccggca aagagaacct     2820

ggaatacccc agcgtgaccc tgcctcctca gcctcacaca aaagaaggcg tggacgccta     2880

caacgaagtg atcgccagag tgagaatgtg ggtcaacctg aacctgtggc agaagctgaa     2940

actgtccagg gacgacgcca agcctctgct gagactgaag ggcttcccta gcttccctct     3000

ggtggaaaga caggccaatg aagtggattg gtgggacatg gtctgcaacg tgaagaagct     3060

gatcaacgag aagaaagagg atggcaaggt tttctggcag aacctggccg gctacaagag     3120

acaagaagcc ctgaggcctt acctgagcag cgaagaggac cggaagaagg gcaagaagtt     3180

cgccagatac cagctgggcg acctgctgct gcacctggaa aagaagcacg gcgaggactg     3240

gggcaaagtg tacgatgagg cctgggagag aatcgacaag aaggtggaag gcctgagcaa     3300

gcacattaag ctggaagagg aaagaaggag cgaggacgcc caatctaaag ccgctctgac     3360

cgattggctg agagccaagg ccagctttgt gatcgagggc ctgaaagagg ccgacaagga     3420

cgagttctgc agatgcgagc tgaagctgca gaagtggtac ggcgatctga gaggcaagcc     3480

cttcgccatt gaggccgaga acagcatcct ggacatcagc ggcttcagca agcagtacaa     3540

ctgcgccttc atttggcaga aagacggcgt caagaaactg aacctgtacc tgatcatcaa     3600

ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa cccgaggcct tcgaggctaa     3660

cagattctac accgtgatca acaaaaagtc cggcgagatc gtgcccatgg aagtgaactt     3720

caacttcgac gaccccaacc tgattatcct gcctctggcc ttcggcaaga gacagggcag     3780

agagttcatc tggaacgatc tgctgagcct ggaaaccggc tctctgaagc tggccaatgg     3840

cagagtgatc gagaaaaccc tgtacaacag gagaaccaga caggacgagc ctgctctgtt     3900

tgtggccctg accttcgaga gaagagaggt gctggacagc agcaacatca agcccatgaa     3960

cctgatcggc gtggaccggg gcgagaatat ccctgctgtg atcgccctga cagaccctga     4020

aggatgccca ctgagcagat tcaaggactc cctgggcaac cctacacaca tcctgagaat     4080

cggcgagagc tacaaagaga agcagaggac aatccaggcc aagaaagagg tggaacagag     4140

aagagccggc ggatactcta ggaagtacgc cagcaaggcc aagaatctgg ccgacgacat     4200

ggtccgaaac accgccagag atctgctgta ctacgccgtg acacaggacg ccatgctgat     4260

cttcgagaat ctgagcagag gcttcggccg gcagggcaag agaaccttta tggccgagag     4320

gcagtacacc agaatggaag attggctcac agctaaactg gcctacgagg gactgagcaa     4380

gacctacctg tccaaaacac tggcccagta tacctccaag acctgcagca attgcggctt     4440

caccatcacc agcgccgact acgacagagt gctggaaaag ctcaagaaaa ccgccaccgg     4500

ctggatgacc accatcaacg gcaaagagct gaaggttgag ggccagatca cctactacaa     4560

caggtacaag aggcagaacg tcgtgaagga tctgagcgtg gaactggaca gactgagcga     4620

agagagcgtg aacaacgaca tcagcagctg gacaaagggc agatcaggcg aggctctgag     4680

cctgctgaag aagaggttta gccacagacc tgtgcaagag aagttcgtgt gcctgaactg     4740

cggcttcgag acacacgccg atgaacaggc tgccctgaac attgccagaa gctggctgtt     4800

cctgagaagc caagagtaca agaagtacca gaccaacaag accaccggca acaccgacaa     4860

gagggccttt gtggaaacct ggcagagctt ctacagaaaa aagctgaaag aagtctggaa     4920

gcccgccgtg actagtccaa aaaagaagag aaaggtagcc ctcgagtacc catatgatgt     4980

ccctgactac gcttga                                                     4996


<210>  928
<211>  5401
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP59 plasmid sequence

<400>  928
atggccgctg tggaaggcga tctggacgtg caagccctga ccgatctgtt caacaacctg       60

ggcatcaacc gggacccccg gcaccgggaa gtgatcgccc tgcggatgac aggcggctgg      120

tggggccctg ccaccagata caacctgatc accgtgctgc tgcaggatga tcagggtcag      180

cctcttcagc agccccggtg gcgggccgag ggccgggccg ccaaccccgc tgtgatgctg      240

accctggaag ccccatggca ggacctgcgg atggcctttg acaacgtcga cctggccgac      300

gacacactgc ggtttggccc tctggctaac ggcaattaca tccccggcga cgagtacagc      360

ctggagttca tccctcccgc catgcaagag atcgcccaaa tgcagagaga tgagctggaa      420

aacgtgctgg acattgtggg ccagatcaca atgcagatga gcgacctgat cggaatgcag      480

gacgcccaga tccggggcct ggagggccaa atcagaggcc tgagaggcaa tctgcccgtg      540

gccggaacac caccacctcc tcctccaagc ctggacctgc agcctgccgc cgccagcagc      600

ccttacgtgg cccctgcgtc tagcgctcct gccgcacccg tggcctctgc tgatctgggc      660

tggttcgccg ggggaccttc cccaggctct gtggaccctc ggctggcccg ggtcgcctac      720

aaccccttcc tgcccggacc tagcgacggc agcggcgtgg ccccggtgca gccctccgcc      780

cctcctgccg ccagccctct gctgcccctg ccacctgctc agcctgtgca gccagtgatc      840

cagtacgtgc accctcctcc tatgaaccct gcccagcaga ttattcctat ccagcacatc      900

agagccgtga ccggcaacgc ccccaccaac cctagagaga tccctatgtg gatcggcaga      960

aacgccagcg ccatcgaggg cgtgttcccc atgaccaccc ctgatctgag gtgtcgggtg     1020

atcaacgccc tgctcggcgg caacctgggc ctgaacctgg aaccacagca ctgcgtgacc     1080

tgggccagcg caatcgccac cctgtacgtt agaacccacg gcagctaccc catccaccag     1140

ctggctgaag tgctgagagg cgtggctaat agcgagggag ttgctgccgc ttatcagctg     1200

ggcatgatgc tgacaaaccg ggattacaac ctgatctggg ggatcatccg ccctctgctg     1260

cccggccagg ccgtcgtgac cgccatgcag catagactgg atcaggagat caacgacgcc     1320

gccagagtgg cctctttcat caatcacctg aacggcgtgt acgagctgct gggcttgaac     1380

gccagaggcc agagcctgag aatccctgcc tctggcggac agaccacggc cggaaccagc     1440

gccggcagag gcacaagagg aagacgcagc cagcaaggca cacctggcag acagagcagc     1500

ggccagagcc agcagcaggg aagaagaagc agccagggcc agagcagaca gtcagactcc     1560

agcgaccaga acgtgcagag acaatcccag ggcggcaacg gacggggagg ctataatctg     1620

agacccagga cctaccagcc ccagagatac ggcggaggca gaggcagaag gtggaacgac     1680

cagcctgcca gatcagacaa ccagcagcgg tcccaatctc aacagcctca gtccgaggct     1740

agaggcgagc agagcagaac cagcggagcc ggcagaggac agggcggccg ggggaatcaa     1800

aacagaaacc agagaagcgc cggtggcaat gccgacagaa cagtgaacac cgtgacaacc     1860

gccagcgctt ctacaagcgc ctcaggtcaa gatggatcct ctccagctcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaattaaa agcccactgg gacagcggag ccaccattac     1980

atgcatcccc gaggcttttc tggaagatga gcagcctatc caaacaatgc tgatcaagac     2040

catccacggc gagaagcagc agaacgtgta ctacctgaca ttcaagatcc agggcagaaa     2100

ggtggaagcc gaggtgctgg cctctcctta tgactacatc ctgctcaatc cttctgatgt     2160

gccatggctg atgaaaaagc ctctgcaact gaccgtgctg gtccccctgc aggactacca     2220

ggagcggctg ctgaaacaga ccaccctgcc taaggaacag aaggaccagc tggaaaagct     2280

gttcctgaag tacgacgccc tgtggcagca ctgggagaac caggtgggcc acagaagagg     2340

tgccagaaca gtgaacaccg tgacaaccgg cggcagccca aagaagaagc ggaaggtctc     2400

tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac     2460

aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga     2520

cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag     2580

caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc     2640

catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt     2700

tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa     2760

gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta     2820

caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa     2880

cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga     2940

tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat     3000

ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag     3060

atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag     3120

cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca     3180

gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt     3240

gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc     3300

cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga     3360

cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc     3420

caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa     3480

agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag     3540

gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct     3600

gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga     3660

tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga     3720

agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc     3780

caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg     3840

cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc     3900

cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg     3960

gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg     4020

caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt     4080

gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc     4140

caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa     4200

cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa     4260

aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt     4320

cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga     4380

ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag     4440

cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa     4500

agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata     4560

ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc     4620

cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag     4680

cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat     4740

ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa     4800

aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc     4860

cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat     4920

caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca     4980

gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa     5040

cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag     5100

gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca     5160

cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga     5220

gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga     5280

aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag     5340

tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg     5400

a                                                                     5401


<210>  929
<211>  5401
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP60 plasmid sequence

<400>  929
atggccgcca tcgagggcga tctggacgtg caggccctgg ctaacctgtt caacgacctg       60

ggcatcaaca gaaaccccag acacagagag gtgattgccc tgagaatgac cggcggctgg      120

tggggccccg ctaccagata taatctggtg agcctgctgc tgcaggacga ccagggccag      180

cctctgccac agcccagatg gcgggctgaa ggcagagccg caaaccccgc cgtgatgttc      240

accctggaag ccccctggca ggatctgaga ctggcctttg acaatatcga cgtgggcgag      300

ggcacactga gattcggccc acttgctaac ggcaactaca tccccggcga cgagttcagc      360

ctggagttcc tgcctcctgc catgcaggag atcacacaga tgcagagaga tgagctggag      420

gaagtgctgg atgtggtggg ccagatcaca atgcagatga acgacctgat cggcatgcag      480

gacgcccaga tccggggact ggaaggacaa ctgagaggac tgagaggcaa tctgccagtg      540

gccggcacac ctccacctcc tccacccagc ctggacctgc agcctgctgc cgccagcagc      600

ccctacgtgg cccctgcacc ttccgctcct gctgcctctg ccgccgcagc cgacctggga      660

tggttcgccg gaggccctgg ccctggatct ctggaccccc gcctcgcccg ggtggcctac      720

aacccctttc tgcctggccc tagcgacggc agcggtgccg ctcccgccca gcctagcgct      780

cctccggtgg cctctcctct gccttctctg ctgcctgccc agcccatgca acctgtgatc      840

cagtacgtgc accccccacc tatcaatcct gctcaacagg tgatccctat tcagcatatc      900

agagccgtga ccggcaacgc ccctagcaac ccaagagaaa tccctatgtg gatcggaaga      960

aacgccagcg ccatcgaggg cgtgttcccc atccctacat ctgacatccg ttctagagtg     1020

atcaacgccc tgctgggtag acagctgggc ctgaacctgg atcctcagca ctgcatcacc     1080

tgggccagcg caatcgccac tctgtacgtg cgcacccacg gcagctaccc tctgcaccag     1140

ctggccgagg ttctgcggag agtctccaac agcgaaggcg cggccgccgc ctggcagctg     1200

ggcatgatgc tgaccaacca ggactacaac ctcgtgtggg gaatggtcag acccctgctg     1260

cccggccagg ctgtggtcac cgccatgcag caccggctgg atcaggaggt ttctgatgcc     1320

gccagaatcg tgtccttcgt gaaccacctg aacgccgtgt acgagctgct gggcctgaat     1380

gccagaggcc agaacctcag ggtctccacc ggcggccaga ccaccgctag aacaagcgcc     1440

ggcagaggcg ccagaggcag acggtcccag caggggaccc ctggcaggca gtctagcgga     1500

caggcccctc ctcaaggccg gagaagcagc cagggccagc agcctaggca gtctgagagc     1560

ggcgaccaga acaaccagcg gcagctccag ggaggaaaca accggggcgg ctataacctg     1620

cggcctcgga cataccagcc tcagcggtac gggggaggcc ggggccggag atggaacgat     1680

cagaccgcca gagccgataa ccagcagcgg agccaatccc aacaacctca gagcgaggcc     1740

cggggcgagc agagcagaac cagcggcgcc ggcagagaac agggcggcag aggcaatcaa     1800

aatcggaatc aaagatctgc cggagaaaac accgacagat ccgtgaacac cgtgacagcc     1860

accagcgcca gcatcagcgc ctcaggtcaa aatggatcct ctacaactcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaattaaa agcccactgg gatagcggag ctacaatcac     1980

ctgcgtgccc gaggcctttc tggaagatga gagacctatc cagaccatgc tgatcaagac     2040

catccacggc gagaagcagc aggacgtcta ctacctgacc ttcaaggtgc agggcagaaa     2100

ggtggaagcc gaggtgctgg cctctcctta tgactacatc ctgctcaacc ccagcgacgt     2160

gccttggctg atgaaaaagc ctctgcagct gacagtgctg gtgccactgc acgagtacca     2220

ggagcggctg ctgcaacaaa ccgccctgcc taaggaacag aaagagctgc tgcagaagct     2280

gttcctgaag tacgacgccc tgtggcagca ttgggaaaac caggtgggcc accggagagg     2340

tgccagatcc gtgaacaccg tgacagccgg cggcagccca aagaagaagc ggaaggtctc     2400

tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac     2460

aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga     2520

cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag     2580

caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc     2640

catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt     2700

tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa     2760

gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta     2820

caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa     2880

cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga     2940

tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat     3000

ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag     3060

atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag     3120

cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca     3180

gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt     3240

gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc     3300

cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga     3360

cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc     3420

caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa     3480

agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag     3540

gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct     3600

gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga     3660

tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga     3720

agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc     3780

caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg     3840

cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc     3900

cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg     3960

gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg     4020

caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt     4080

gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc     4140

caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa     4200

cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa     4260

aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt     4320

cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga     4380

ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag     4440

cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa     4500

agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata     4560

ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc     4620

cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag     4680

cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat     4740

ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa     4800

aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc     4860

cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat     4920

caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca     4980

gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa     5040

cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag     5100

gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca     5160

cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga     5220

gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga     5280

aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag     5340

tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg     5400

a                                                                     5401


<210>  930
<211>  5811
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP61 plasmid sequence

<400>  930
atggggcaag aattaagcca gcatgaacgt tatgtagaac aattgaagca ggctttaaag       60

acacggggag taaaggttaa atatgctgat cttttgaaat tttttgattt tgtgaaggat      120

acttgtcctt ggtttccgca agagggaacc atagatatta aacggtggcg tagagtaggc      180

gactgtttcc aagactatta caatactttt ggcccggaga aagtcccagt aactgcattc      240

tcttactgga acttaattaa agaattgata gataagaaag aagttaaccc acaagtaatg      300

gctgccgtag cccaaactga agaaatttta aaaagtaatt ctcaaacaga cctcacaaag      360

acctctcaaa acccagactt ggaccttatt tcccttgata gcgacgatga aggagctaaa      420

agttcctctc tacaagataa aggtttatca agtactaaaa aaccaaaaag attcccagtt      480

ctgttaacag cacaaactag taaagaccct gaagacccca acccctcaga ggtagactgg      540

gacggcttgg aagatgaggc agcgaaatat cataatcccg attggcctcc cttcctaacc      600

cgtccacctc cttacaataa agctactcct tccgcaccca ctgtaatggc ggttgttaat      660

ccaaaagagg agctcaaaga aaaaattgct caattagagg aacagattaa attagaagag      720

ttacaccagg cactaatttc caaattacaa aaactaaaaa cagggaatga aactgtaact      780

cacccagaca cagcaggagg cctttctcgc acgcctcact ggccagggca acatatccct      840

aaaggaaaat gttgcgccag tcgagaaaag gaagaacaaa tcccaaaaga tattttccca      900

gtgactgaaa ccgttgatgg gcaaggtcaa gcctggagac accataatgg ttttgatttt      960

gccgtcataa aagaattaaa aacagctgct tcccaatatg gggctactgc cccatacaca     1020

ttagccatag tggaatctgt agcggacaat tggcttaccc ctacagattg gaatacgctt     1080

gttagggcag tcctctcagg aggagatcac ttactgtgga aatctgagtt ttttgaaaat     1140

tgcagagata cggctaaaag aaaccaacaa gccggtaatg gctgggattt tgacatgtta     1200

acaggttcgg gtaattattc cagcaccgat gcacaaatgc agtatgatcc aggattgttt     1260

gctcaaattc aagcggctgc tacaaaagcc tggagaaaac ttcccgttaa gggagaccca     1320

ggagcctccc ttacaggagt caaacaagga cccgatgagc catttgcaga tttcgtacac     1380

agacttataa caactgctgg gagaatcttt ggaagtgctg aggccggtgt agactatgta     1440

aaacaactag catatgaaaa tgctaatcca gcttgtcagg cagccattcg cccctataga     1500

aagaagacag atttaactgg ctatatccgt ctttgctcgg atattgggcc ctcttatcag     1560

caaggcctgg ccatggccgc cgcctttagc gggcagactg taaaagattt tcttaacaac     1620

aaaaataaag agaaaggagg gtgttgcttt aaatgcggta aaaaaggaca ctttgcaaaa     1680

aattgtcatg aacatgcaca taacaatgct gaaccaaaag ttcccggact ctgccctaga     1740

tgtaaaagag ggaaacattg ggccaatgaa tgcaaatcca aaactgataa tcaaggaaac     1800

ccaataccac cccatcaggg aaacggggcc agccccaggc cccgaaacaa gcttatgggg     1860

cagtcagctt tgttccagcc aacaaaaaca acccatttca aagcttacca gagccacccc     1920

aggaagtgca ggattggacc tctgttccac ctcccacaca gtattaacgc ctgaaatggg     1980

gccccaagcg ttaagcactg gaatatatgg accactgcct cccaacactt ttggattaat     2040

cctaggccga agtagcatta ctatgaaggg tctacaagtt tatccaggag taattgataa     2100

tgactatacc ggagaaatta aaattatggc aaaagctgtt aacaatattg ttactgtctc     2160

tcaaggcaac agaatagctc aattaatcct cctgcctctg atcgagacag acaataaggt     2220

acaacaacct tatagaggac aaggaagttt tggatcctca gacatatatt gggtccaacc     2280

tattacttgt caaaaacctt ccttaacatt atggttagat gacaaaatgt tcacaggctt     2340

aatagatacg ggggctgatg tcacaattat caagctggag gactggcctc ctaattggcc     2400

tataacagat accttaacca atttaagagg aataggacaa agtaacaacc ctaaacaaag     2460

ttctaaatat cttacttgga gagataaaga aaacaattct ggtctcatca aaccgtttgt     2520

tattcctaac ttacctgtca atctttgggg ccgagattta ctttctcaaa tgaaaattat     2580

gatgtgtagc cccaatgaca tagtaactgc tcaaatgtta gcccagggct acagcccagg     2640

aaaagggtta ggaaaaaagg aaaatggcat tctacatcct atcccaaatc aaggacaatc     2700

taacaaaaaa ggttttggaa atttttaact gcggccattg acatacttgg tgccccacag     2760

gtgatggctg ctgtcgccgg cggcagccca aagaagaagc ggaaggtctc tagacaagag     2820

atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac aaagaaggcc     2880

ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga cctgagagag     2940

cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag caacaccagc     3000

agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc catcctgcac     3060

gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt tgctcagcct     3120

gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa gggcaatctg     3180

accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta caagctggaa     3240

caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa cgtggccgag     3300

cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga tgaggccgtg     3360

acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat ccacgtgacc     3420

aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag atacgcctct     3480

ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag cttcctgagc     3540

aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca gaagagactg     3600

gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt gaccctgcct     3660

cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc cagagtgaga     3720

atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga cgccaagcct     3780

ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc caatgaagtg     3840

gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa agaggatggc     3900

aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag gccttacctg     3960

agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct gggcgacctg     4020

ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga tgaggcctgg     4080

gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga agaggaaaga     4140

aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc caaggccagc     4200

tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg cgagctgaag     4260

ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc cgagaacagc     4320

atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg gcagaaagac     4380

ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg caagctgcgg     4440

ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt gatcaacaaa     4500

aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc caacctgatt     4560

atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa cgatctgctg     4620

agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa aaccctgtac     4680

aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt cgagagaaga     4740

gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga ccggggcgag     4800

aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag cagattcaag     4860

gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa agagaagcag     4920

aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata ctctaggaag     4980

tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc cagagatctg     5040

ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag cagaggcttc     5100

ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat ggaagattgg     5160

ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa aacactggcc     5220

cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc cgactacgac     5280

agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat caacggcaaa     5340

gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca gaacgtcgtg     5400

aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa cgacatcagc     5460

agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag gtttagccac     5520

agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca cgccgatgaa     5580

caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga gtacaagaag     5640

taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga aacctggcag     5700

agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag tccaaaaaag     5760

aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg a              5811


<210>  931
<211>  5077
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP62 plasmid sequence

<400>  931
atgggccaaa tcttttcccg tagcgctagc cctattccgc gaccgccccg ggggctggcc       60

gctcatcact ggcttaactt cctccaggcg gcatatcgcc tagaacccgg tccctccaat      120

tgcgctttcc acctgttaag aagatatcat gaaacagttt ccggaatacc ggctcggatc      180

tgtcccatta actactccct cctagccagc ctactcccaa aaggataccc cggccgggtg      240

aatgaaattt tacacatact catccaaacc caagcccaga tcccgtcccg tcccgcgcca      300

ccgccgccgt catcccccac ccacgacccc ccggattctg atccacaaat cccccctccc      360

tatgttgagc ctacggcccc ccaagtcctt ccagtcatgc atccacatgg tgctcctcct      420

aaccatcgcc catggcaaat gaaagaccta caggccatta agcaagaagt ctcccaagca      480

gcccctggga gcccccagtt tatgcagacc atccggcttg cggtgcagca gtttgacccc      540

actgccaaag acctccaaga cctcctgcag tacctttgct cctccctcgt ggcttccctc      600

catcaccagc agctagatag ccttatatca gaggccgaaa cccgaggtat tacaggttat      660

aacccattag ccggtcccct ccgtgtccaa gccaacaatc cacaacaaca aggattaagg      720

cgagaatacc agcaactctg gctcgccgcc ttcgccgccc tgccggggag tgccaaagac      780

ccttcctggg cctctatcct ccaaggcctg gaggagcctt accacgcctt cgtagaacgc      840

ctcaacatag ctcttgacaa tgggctgcca gaaggcacgc ccaaagaccc catcttacgt      900

tccttagcct actccaatgc aaacaaagaa tgccaaaaat tactacaggc ccgaggacac      960

actaatagcc ctctaggaga tatgttgcgg gcttgtcaga cctggacccc caaagacaaa     1020

accaaagtgt tagttgtcca gcctaaaaaa ccccccccaa atcagccgtg cttccggtgc     1080

gggaaagcag gccactggag tcgggactgc actcagcctc gtcccccccc cgggccatgc     1140

cccctatgtc aagacccaac tcactggaag cgagactgcc cccgcctaaa gcccactatc     1200

ccagaaccag agccagagga agatgccctc ctattagacc tccccgctga cattccacac     1260

ccaaaaaact ccataggggg ggaggtttaa cctccccccc cacattacag caagtctttc     1320

ttaaccaaga cccagcatct attctgccag ttataccgtt agatcccgcc cgtcggcccg     1380

taattaaagc ccaggttgac acccagacca gccacccaaa gactatcgaa gctctactag     1440

atacaggagc agacatgaca gtccttccga tagccttgtt ctcaagtaat actcccctca     1500

aaaatacatc cgtattaggg gcagggggcc aaacccaaga tcactttaag ctcacctccc     1560

ttcctgtgct aatacgcctc cctttccgga caacgcctat tgttttaaca tcttgcctag     1620

ttgataccaa aaacaactgg gccatcatag gtcgcgatgc cttacaacaa tgccagggcg     1680

tcctgtacct ccctgaggca aaagggccgc ctgtaatctt gccaatacag gcgccagccg     1740

tccttggact agaacacctc ccaaggcccc cccaaatcag ccagttccct ttaaaccaga     1800

acgcctccag gccttgcaac acttggtccg gaaggccctg gaggcaggcc atatcgaatc     1860

ctacaccggg ccaggaaata acccagtatt cccagttaaa aaggccaatg gaacctggcg     1920

attcatccac gacctgcggg ccactaactc tctaaccata gacctctcat catcttcccc     1980

cgggccccct gacttgtcca gcctgccaac cacacgtgcc cctcaagtgc tgccagtgat     2040

gcacggcggc agcccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa     2100

caagatcaga aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc     2160

catgaaaacc ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct     2220

gagaaagaag cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa     2280

caagctgctg accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga     2340

gttccagaaa gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat     2400

cgaccagaac aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt     2460

tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa     2520

aggcaaggcc tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat     2580

tctgctggcc cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg     2640

caagtttgga cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca     2700

ccccgtgaag cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa     2760

agccctgtcc gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat     2820

catcatcgag caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga     2880

gctggccggc aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac     2940

aaaagaaggc gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct     3000

gaacctgtgg cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa     3060

gggcttccct agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat     3120

ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca     3180

gaacctggcc ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga     3240

ccggaagaag ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga     3300

aaagaagcac ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa     3360

gaaggtggaa ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc     3420

ccaatctaaa gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg     3480

cctgaaagag gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta     3540

cggcgatctg agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag     3600

cggcttcagc aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact     3660

gaacctgtac ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa     3720

acccgaggcc ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat     3780

cgtgcccatg gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc     3840

cttcggcaag agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg     3900

ctctctgaag ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag     3960

acaggacgag cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag     4020

cagcaacatc aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt     4080

gatcgccctg acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa     4140

ccctacacac atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc     4200

caagaaagag gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc     4260

caagaatctg gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt     4320

gacacaggac gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa     4380

gagaaccttt atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact     4440

ggcctacgag ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa     4500

gacctgcagc aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa     4560

gctcaagaaa accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga     4620

gggccagatc acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt     4680

ggaactggac agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg     4740

cagatcaggc gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga     4800

gaagttcgtg tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa     4860

cattgccaga agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa     4920

gaccaccggc aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa     4980

aaagctgaaa gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc     5040

cctcgagtac ccatatgatg tccctgacta cgcttga                              5077


<210>  932
<211>  4871
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP63 plasmid sequence

<400>  932
atgggcgcga gaaactccgt cttgtcaggg aaggaagcag atgaattaga aaaagttagg       60

ttacggccca acggaaagaa aaagtatatg ttgaagcatg tagtatgggc agcaaatgaa      120

ttggacagat ttggattagc agaaagcctg ttggataaca aagaaggttg tcaaaaaatt      180

ctttcagttt tagctccatt agttccgaca ggttcagaaa acttaaagag cctttataat      240

actgtctgcg tcatttggtg cattcacgca gaagagaaag tgaaacatac tgaggaagca      300

aaacaaatag tgcagagaca tctagtggtg gaaacaggaa cagcagacag aatgccagca      360

acaagcagac caacagcacc acctagtggc agaggaggaa attacccagt gcagcaagta      420

ggtggcaatt atgtccacct acccttaagt ccaagaacat taaatgcttg ggtaaaatta      480

gtagaagaga aaaaatttgg ggcagaggta gtgccaggat ttcaagcgct atcagaaggc      540

tgcactccct atgatattaa tcaaatgcta aattgtgtag gagaacatca ggcagccatg      600

caaattatta gagagattat aaatgaagaa gctgccgatt gggatttaca acacccgcaa      660

ccaggtccac taccagcagg gcaacttaga gagccaagag gatcagacat tgcaggaact      720

actagtacag tagatgaaca aatccaatgg atgtacaggc aacaaaaccc cataccagta      780

ggcaacattt atagaaggtg gatccaatta gggctgcaga aatgtgtaag aatgtataac      840

ccaacaaaca ttttagatgt gaaacaagga ccaaaagagc catttcaaag ctacgtagat      900

agattctaca aaagtctaag agcagagcaa acagatcccg cagtaaagaa ttggatgacc      960

caaacactgc tgattcaaaa tgctaaccca gattgtaaac tagtgctcaa gggtctgggc     1020

atgaatccca ctttagaaga aatgctgaca gcctgtcagg gagtaggagg gccaggacaa     1080

aaagctaggt taatggcaga agcattgaaa gaggcactga ggccagatca actcccattt     1140

gcagcagtcc aacagaaagg acaaaggaag acaatcaagt gttggaattg tggaaaggag     1200

ggacactctg caaaacaatg cagggcccct agaagacagg gctgctggaa gtgtggaaaa     1260

acgggtcatg ttatggccaa atgccctgaa agacaggcgg gttttttagg gcttggccca     1320

tggggaaaga agccccgcaa tttccccatg gcccagatgc ctcaggggct gataccaact     1380

gctcccccag aggatccagc tgtggatcta ctgaagaatt acatgaagat gggcagaaag     1440

cagagggaga acagagagag accttacaag gaggtgacag aggatttgct gcacctcaat     1500

tctctctttg gagaagacca gtagtcactg cctacattga agaacagccc gtagaagtat     1560

tattagatac aggggctgac gattcaattg tagcagggat agaattgggt ccaaattata     1620

cccctaaaat agtaggagga ataggaggct tcattaacac caaagaatat aaagatgtaa     1680

aaataaaagt cttaggcaag gtaattaagg gaacaattat gacgggagat accccaatta     1740

atatttttgg cagaaatttg ctaacagcta tgggcatgtc tttaaatctc cccatagcta     1800

aggtggaggg tgccggcggc aactaccccg tgcagcaagg cggcagccca aagaagaagc     1860

ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg     1920

acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga     1980

tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc     2040

agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga     2100

tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga     2160

tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga     2220

tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc     2280

tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg     2340

gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga     2400

aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact     2460

tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg     2520

ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa     2580

caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca     2640

agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat     2700

accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg     2760

aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt     2820

ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg     2880

aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca     2940

acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag     3000

aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca     3060

gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca     3120

aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca     3180

ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt     3240

ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt     3300

tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg     3360

ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg     3420

ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact     3480

tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat     3540

tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact     3600

tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt     3660

tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag     3720

tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg     3780

ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga     3840

tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat     3900

gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg     3960

agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag     4020

ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc     4080

gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg     4140

agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt     4200

acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct     4260

acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca     4320

tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga     4380

tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt     4440

acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga     4500

gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc     4560

tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct     4620

tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga     4680

gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg     4740

cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg     4800

ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg     4860

actacgcttg a                                                          4871


<210>  933
<211>  4805
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP88 plasmid sequence

<400>  933
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccaaag aagaagcgga     1800

aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg gtcaaggaca     1860

gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc agagtgatga     1920

cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac atccctcagc     1980

ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac accgagatga     2040

agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg ggcctgatga     2100

gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag cccgagatgg     2160

acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc cagcctctgt     2220

tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac tacttcggca     2280

gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa cctgagaagg     2340

actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc ctggacttct     2400

acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct cagatcgccg     2460

gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc atgggaacaa     2520

tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag gtggtcaagg     2580

gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac ctggaatacc     2640

ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc tacaacgaag     2700

tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg aaactgtcca     2760

gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct ctggtggaaa     2820

gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag ctgatcaacg     2880

agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag agacaagaag     2940

ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag ttcgccagat     3000

accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac tggggcaaag     3060

tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc aagcacatta     3120

agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg accgattggc     3180

tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag gacgagttct     3240

gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag cccttcgcca     3300

ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac aactgcgcct     3360

tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc aattacttca     3420

aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct aacagattct     3480

acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac ttcaacttcg     3540

acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc agagagttca     3600

tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat ggcagagtga     3660

tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg tttgtggccc     3720

tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg aacctgatcg     3780

gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct gaaggatgcc     3840

cactgagcag attcaaggac tccctgggca accctacaca catcctgaga atcggcgaga     3900

gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag agaagagccg     3960

gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac atggtccgaa     4020

acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg atcttcgaga     4080

atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag aggcagtaca     4140

ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc aagacctacc     4200

tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc ttcaccatca     4260

ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc ggctggatga     4320

ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac aacaggtaca     4380

agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc gaagagagcg     4440

tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg agcctgctga     4500

agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac tgcggcttcg     4560

agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg ttcctgagaa     4620

gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac aagagggcct     4680

ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg aagcccgccg     4740

tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat gtccctgact     4800

acgct                                                                 4805


<210>  934
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  934

Asp Cys Leu Asp Phe Asp Asn Asp 
1               5               


<210>  935
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  935

Asp Leu Val Leu Leu Ser Ala Glu 
1               5               


<210>  936
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  936

Pro Gln Val Met Ala Ala Val Ala 
1               5               


<210>  937
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  937

Ala Arg Gln Met Thr Ala His Thr 
1               5               


<210>  938
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  938

Ser Ser Leu Tyr Pro Val Leu Pro 
1               5               


<210>  939
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  939

Ser Ser Leu Tyr Pro Ala Leu Thr 
1               5               


<210>  940
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  940

Ala Gly Gly Arg Ser Trp Lys Ala 
1               5               


<210>  941
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  941

Ser Glu Glu Tyr Pro Ile Met Ile 
1               5               


<210>  942
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  942

Gly Gly Asn Tyr Pro Val Gln Gln 
1               5               


<210>  943
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  943

Arg Glu Val Tyr Pro Ile Val Asn 
1               5               


<210>  944
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  944

Thr Ser Cys Tyr His Cys Gly Thr 
1               5               


<210>  945
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  945

Pro Ala Ile Leu Pro Ile Ile Ser 
1               5               


<210>  946
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  cleavage site

<400>  946

Pro Gln Val Leu Pro Val Met His 
1               5               


<210>  947
<211>  2413
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pStx42.174.12.7 plasmid sequence

<400>  947
gctagctagg tctagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt       60

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa      120

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt      180

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa      240

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac      300

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt      360

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt      420

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat      480

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac      540

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg      600

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc      660

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa      720

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag      780

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct      840

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat      900

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa      960

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     1020

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     1080

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     1140

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     1200

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     1260

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     1320

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     1380

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     1440

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     1500

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     1560

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     1620

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     1680

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     1740

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     1800

ccgacaggcc cgaaggaata gaagaagaag gtggagagag agacagagac agatccattc     1860

gattagtgaa cggatctcga cggtatcgcc tttaaaagaa aaggggggat tggggggtac     1920

agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa agaactacaa     1980

aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag agatccagtt     2040

tgagggccta tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga     2100

gataattgga attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag     2160

aaagtaataa tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca     2220

tatgcttacc gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg     2280

acgaaacacc actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc     2340

gtagtgggta aagctccctc ttcggaggga gcatcaaagc tgcattctag ttgtggtttt     2400

tttttttgaa ttc                                                        2413


<210>  948
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 plasmid sequence

<400>  948
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  949
<211>  5178
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP40 plasmid sequence

<400>  949
atggaagccg tgatcaaggt gatcagctcc gcatgcaaga cctactgtgg caagacgagc       60

ccaagcaaga aggaaatcgg cgctatgctg agcctgctgc agaaggaggg cctcctgatg      120

agcctgtctg atctgtacag cccaggtagc tgggacccta tcaccgccgc cctgacacag      180

agagccatgg tgctgggcaa aagcggcgag ctgaagacat ggggactggt gctgggcgcc      240

ctgaaagccg ctagagaaga gcaagtaacc agcgagcagg ccaagttctg gctgggactg      300

ggcggcggta gagtgagccc ccctggccct gagtgcatcg agaagcctgc caccgagcgg      360

cgcattgaca aaggcgaaga agtgggcgag acaaccgtgc agagagacgc caagatggct      420

ccagaagaga cagcaacccc aaagaccgtg ggcaccagct gctaccactg cggcaccgct      480

atcggctgca actgcgccac cgccagcgcg cctcctcccc cgtatgtggg cagcggcctc      540

tacccctccc tggcaggagt gggagagcag cagggccagg gcggagatac acccagaggc      600

gccgagcagc ctagagccga acccggccac gccggccagg cccctggccc cgccctgacc      660

gactgggcca gaatcagaga ggagctggcc tctacaggcc ctccagtggt cgccatgcct      720

gtggtgatca agaccgaggg acctgcctgg acccctctgg aacctaaact gattacacgg      780

ctggctgata ccgtcagaac caagggcctc agaagcccca tcacaatggc cgaagtggaa      840

gccctgatga gcagcccact gctgcctcac gacgtgacca acctgatgcg ggtgatcctg      900

ggccccgccc cttacgccct gtggatggac gcctggggcg tgcagctgca aacagttatc      960

gccgccgcca caagagaccc ccggcaccca gccaacggcc agggcagagg cgagagaaca     1020

aacctggatc ggctgaaggg cctcgccgat ggcatggccg gcaatcctga gggccaggct     1080

gctctgctga gacccgggga actggttgct atcaccgcca gcgccctgca ggccttcaga     1140

gaagtggccc ggctggccga gcctacagac ccctgggccg agatcaccca gggcccttct     1200

gagagcttcg tggacttcgc caacagactg atcaaggccg ttgagggctc cgacctgcct     1260

cctagcgccc gcgcccccgt gatcatcgac tgttttagac agaaatcgca acccgacatc     1320

cagcagctga tccgggccgc tccttctacc ctgaccacac ctggcgagat catcaagtac     1380

gtgctggaca gacagaagac cgcccccctg accgacagag gaatcgccgc cgccatgtct     1440

agcgccattc agcctctggt gatggccgtg gtcaacagag aaagagatgg acagacaggt     1500

tctggcggca gagcccgggg cctgtgctac acctgcggat cccctggaca ctaccaggcc     1560

cagtgtccta agaaaagaaa gtctggtaac agcagagagc ggtgccagct gtgtgatggc     1620

atgggccaca acgccaaaca gtgccggaga cgggacggaa accaaggaca aagacccggc     1680

cggggactga gcagcggacc ttggcctgtc agccagcaac ctgccgtgtc cctggctatg     1740

accatggaac acaaggaccg gcctctggtg cgggtgatcc tgacaaatac cggctctcac     1800

cccgtgaagc agcggtcagt gtacatcaca gccctgctgg acagcggcgc tgatatcacc     1860

atcattagcg aggaggactg gcctaccgac tggcccgtga tggaagctgc caatccccag     1920

atccacggca tcggaggcgg aatcccgatg agaaagtcca gagacatgat cgaggtgggc     1980

gtgatcaacc gggacggctc tcttgagaga cctctgctgc tgttccccgc cgtggctatg     2040

gtgcgaggca gcatcctggg ccgcgactgc ctgcagggcc tgggcctgag actgaccaac     2100

ctgaacttta gccagggtgc caccagctgc taccactgcg gcaccggcgg cagcccaaag     2160

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     2220

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     2280

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     2340

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     2400

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     2460

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     2520

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     2580

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     2640

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     2700

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     2760

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2820

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2880

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2940

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     3000

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     3060

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     3120

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     3180

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     3240

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     3300

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     3360

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     3420

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     3480

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     3540

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     3600

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     3660

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     3720

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3780

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3840

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3900

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3960

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     4020

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     4080

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     4140

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     4200

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     4260

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     4320

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     4380

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     4440

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     4500

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     4560

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     4620

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     4680

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     4740

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4800

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4860

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4920

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4980

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     5040

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     5100

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     5160

gtccctgact acgcttga                                                   5178


<210>  950
<211>  5187
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP41 plasmid sequence

<400>  950
atggaggccg tgatcaaggt gatcagcagc gcatgcaaga cctactgcgg caagaccagc       60

ccatctaaga aagagatcgg cgccatgctg agcctgctcc aaaaggaagg cctgctgatg      120

agcccttccg acctgtacag ccccggaagc tgggacccaa tcaccgctgc cctgacccag      180

cgggccatgg tgctgggaaa gagcggcgag ctgaagacct ggggcctggt gctgggagcc      240

ctgaaggccg ccagagagga acaagtgaca agcgaacagg ccaagttctg gctgggactg      300

ggcggaggaa gagtcagccc tcctggccca gagtgcatcg agaagcccgc tacagagaga      360

agaatcgata agggcgaaga ggtgggcgag acaacagtgc agagagacgc caagatggct      420

cctgaggaaa ccgccacacc taagaccgtg ggcacatctt gttaccactg cggcaccgcc      480

attggatgta actgcgctac agccagcgcc cccccccctc cctacgtggg cagcggactt      540

tatcctagcc tggccggcgt gggagagcag cagggccaag gcggagatac acccagaggc      600

gccgagcagc ctagagccga acccggccac gccggactgg cccctggccc agccctgacc      660

gactgggccc gcatccggga agaactggct tctaccggcc ccccggtggt cgccatgcct      720

gtggttatca agacagaggg ccctgcttgg acccctctgg aaccaaagct gattacaaga      780

ctcgccgaca ccgtgcggac caagggcctg cggagcccta tcaccatggc cgagatggaa      840

gctctgatga gcagcccact gctgccccac gacgtgacca acctgatgag agtgatcctg      900

ggccccgccc cttacgccct gtggatggac gcctgggggg tgcagctgca gaccgtgatt      960

gccgccgcca ccagagatcc tagacaccct gctaacggcc aaggcagagg cgaaagaacc     1020

aaccttgaca gactgaaagg cctggccgat ggaatggtcg gcaacagcga aggccaggcc     1080

gccctgctga gacctggcga gctggtggct atcacagcca gcgccctgca ggccttcaga     1140

gaagtggccc gactggctga gcccacggac ccttgggccg acatcatgca gggcccttct     1200

gagagcttcg tggacttcgc caatagactg atcaaggccg tcgagggcag cgatcttcct     1260

cctagcgcga gagcccctgt tatcatcgac tgcttccggc agaaaagcca gcccgacatc     1320

caacagctga tcagagccgc cccttccacc ctgaccacac caggcgagat catcaagtac     1380

gtgctggata gacagaagac cgcccctctg accgatcagg gcatcgccgc tgccatgtcc     1440

tctgccatcc agcctctggt gatggccgtg gtgaacagag agagagacgg ccagacaggc     1500

tccggcggcc gggccagaga gctgtgctac acctgtggct ctccaggcca ctaccaggct     1560

cagtgtccta aaaagcggaa gtctggcaat tctagagagc ggtgccagct gtgcaacggc     1620

atgggccata atgccaaaca gtgtcggaaa cgggacggaa accagggcca gagaccaggc     1680

agaggcctgt cttctggccc ctggcccggc cctgagcctc ctgctgtgtc cctggctatg     1740

accatggaac acaaggacag acccctggtg cgggtgatcc tgacaaacac cggaagccac     1800

cccgtgaagc agcgctccgt gtacatcaca gcccttctgg acagcggcgc cgacatcacc     1860

atcatcagcg aggaagattg gcctacagac tggcctgtga tggaagccgc aaacccccag     1920

atccacggca tcggcggagg tatacccatg cggaagagca gagacatgat cgagctgggc     1980

gtgatcaacc gggacggcag cctggaacgg cccctgctgt tgtttcctgc tgtggctatg     2040

gtgcggggaa gcatcctggg cagagattgc ctgcagggcc tgggcctgcg cctgaccaac     2100

ctgtgaggag ggccactgtt ctcaggtgcc acatcttgtt accactgcgg caccggcggc     2160

agcccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa caagatcaga     2220

aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc catgaaaacc     2280

ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct gagaaagaag     2340

cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa caagctgctg     2400

accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga gttccagaaa     2460

gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat cgaccagaac     2520

aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt tgcctgctct     2580

cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa aggcaaggcc     2640

tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat tctgctggcc     2700

cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg caagtttgga     2760

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag     2820

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc     2880

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag     2940

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc     3000

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc     3060

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg     3120

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     3180

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     3240

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     3300

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     3360

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     3420

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     3480

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     3540

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     3600

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     3660

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     3720

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     3780

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     3840

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     3900

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     3960

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     4020

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     4080

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     4140

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     4200

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     4260

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     4320

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     4380

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     4440

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     4500

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     4560

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     4620

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     4680

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     4740

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     4800

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     4860

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     4920

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     4980

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     5040

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     5100

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc cctcgagtac     5160

ccatatgatg tccctgacta cgcttga                                         5187


<210>  951
<211>  5684
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP42 plasmid sequence

<400>  951
atgggccaga cccacagcag acaactgttc gtgcacatgc tgtccgtgat gctgaagcac       60

agaggcatca ccgtgtctaa gcctaagctg atcaacttcc tgagcttcat cgaggaagtg      120

tgtccttggt ttccacggga aggcacagtg aacctggaaa catggaaaaa ggtgggcgaa      180

cagatcagaa cccactacac cctgcacggc cctgagaagg tgcctgtgga aacactttcc      240

ttctggaccc tgatccgcga ctgcctggat ttcgacaatg acgagctgaa aagactgggc      300

aacctgctca agcaggagga agatcctctg cacgaccctg acagcgagaa cagctacgac      360

gcccctcctc ctcctcatcc tagcctgcac tctagcagac cttccgacaa cgacgacctg      420

ctgtctagca cagacgaggc cgagctggac gaggaagccg ccaagtacca ccaggaggac      480

tggggcttcc tggctcagga gaaaggcgcc ctgacaagca aggacgagct ggtggaatgt      540

ttcaagaacc tgaccatcgc cctgcagaac gctggaatca agctgccagc caacaacgat      600

aagttcccct ccgccccccc tctgcctcct gcctacgccc ctagcgtggt ggccggactg      660

gatccacccc ccggccccct gcccccaagc aagaacatgt ctccactgca gaaagccctg      720

agacaagccc agaggctggg cgaagttgtg tccgatttca gcctggcctt ccccgtgttc      780

gagaacaaca accagcggta ctacgagagc ctgcctttca agcagctgaa ggaactcaaa      840

atcgcatgca gccagtacgg ccctaccgca ccttttacca tcgccatgat cgagaacctc      900

ggcacccagg ccctgccacc taatgattgg aagcagacag ccagagcctg cctgtcaggc      960

ggagattacc tgctgtggaa gagcgagttc ttcgagcaat gcgccagaat cgctgacgtg     1020

aaccggcagc agggcatcca gacgagctac gagatgctga tcggcgaggg accctaccag     1080

gccaccgaca cccagctgaa cttcctgcct ggggcctatg cccaaatcag caacgccgcc     1140

agacaggctt ggaagaaact gcctagctct tctacaaaga ccgaggacct gagcaaagtg     1200

cggcaaggcc ccgatgagcc ctaccaggac tttgtcgcca gactgctcga caccatcggc     1260

aagatcatga gcgacgaaaa ggccggcatg gtcctggcta agcaactggc tttcgagaat     1320

gctaatagcg cctgtcaggc cgccctgcgg ccttacagaa agaagggcga cctgtccgat     1380

tttatcagaa tctgcgccga catcggcccc tcttatatgc agggaattgc catggccgct     1440

gctctgcagg gcaaaagcat caaggaagtg cttttccagc agcaagctcg gaacaagcgg     1500

ggaagacaga gaagcggcaa tagcggttgt tttgtgtgcg gccagcccgg ccaccgcgcc     1560

gccgtgtgcc cccagaagca gcagagcccc gtgaacaccc ctaatctgtg cccgcgctgt     1620

aaaaaaggaa agcattgggc acgagattgc cggtccaaaa cagatgttca aggtacccct     1680

ttacccccgg tgtcgggaaa ctgggtgagg ggccagcccc tggccccgaa acaatgttat     1740

ggggcaacac tgcaggttcc aaaagaacca ttgcagacct ctgtcgagcc acaagaggca     1800

gcgcgggatt ggacctctgt gccacctcct acacagtatt aactcccgag atgggggtcc     1860

aaaccctggc tacaggcgtg ttcggtcctc tgccccccgg caccgccggc ctgctgctgg     1920

gcagaagcag cgccagcctg aagggcatcc tgatccatcc tggagtgatt gacagcgact     1980

acaccggcga gatcaagatc ctggcctctg cccctaacaa gatcatcgtg atcaacgccg     2040

gccaaagaat cgcccagctg ctgctcgtgc ctctggtgat ccagggcaaa accatcaacc     2100

gggacaggca ggacaaggga tttggatctt ctgacgccta ttgggtgcag aacgtgaccg     2160

aggccagacc tgaactggaa cttagaatca atggcaagct gttccggggc gtgctggata     2220

caggcgccga catcagcgtg atcagcgaca aatactggcc caccacctgg cctaagcaga     2280

tggctatctc tacactgcag ggcatcggcc agacaaccaa ccccgagcag agcagcagcc     2340

tgctgacctg gaaggacaag gacggccaca ccggccaatt caagccctac atcctgcctc     2400

acctgcctgt gaacctgtgg ggcagagata tcctgagcaa gatgggcgtc tacctgtact     2460

cccctagccc taccgtgaca gatctgatgc tggaccaggg cctgctgcct aatcagggcc     2520

tcggaaagca acaccaggga attatcctgc cactggacct gaaaagcaac caggatagaa     2580

agggcctggg atgcttcccc tgaggacctc tgattctcct gggtgccgac tgcctggatt     2640

tcgacaatga cggcggcagc ccaaagaaga agcggaaggt ctctagacaa gagatcaaga     2700

gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag gccggcaaga     2760

caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga gagcggctgg     2820

aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc agcagggcca     2880

acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg cacgtgtact     2940

gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag cctgccagca     3000

agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat ctgaccacag     3060

ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg gaacaggtgt     3120

ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc gagcacgaga     3180

agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc gtgacctaca     3240

gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg accaaagaaa     3300

gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc tctggacctg     3360

tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg agcaagtacc     3420

aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga ctggaaagcc     3480

tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg cctcctcagc     3540

ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg agaatgtggg     3600

tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag cctctgctga     3660

gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa gtggattggt     3720

gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat ggcaaggttt     3780

tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac ctgagcagcg     3840

aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac ctgctgctgc     3900

acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc tgggagagaa     3960

tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa agaaggagcg     4020

aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc agctttgtga     4080

tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg aagctgcaga     4140

agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac agcatcctgg     4200

acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa gacggcgtca     4260

agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg cggttcaaga     4320

agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac aaaaagtccg     4380

gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg attatcctgc     4440

ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg ctgagcctgg     4500

aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg tacaacagga     4560

gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga agagaggtgc     4620

tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc gagaatatcc     4680

ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc aaggactccc     4740

tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag cagaggacaa     4800

tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg aagtacgcca     4860

gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat ctgctgtact     4920

acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc ttcggccggc     4980

agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat tggctcacag     5040

ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg gcccagtata     5100

cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac gacagagtgc     5160

tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc aaagagctga     5220

aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc gtgaaggatc     5280

tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc agcagctgga     5340

caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc cacagacctg     5400

tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat gaacaggctg     5460

ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag aagtaccaga     5520

ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg cagagcttct     5580

acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa aagaagagaa     5640

aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga                      5684


<210>  952
<211>  5637
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP43 plasmid sequence

<400>  952
atgggcgtgt ccggctcaaa gggccagaag ctgtttgtgt ccgtgctgca gcgtctgctg       60

tccgaacggg gcctacacgt gaaagagagc agcgccatcg agttctacca gtttctgatc      120

aaggtgtcac cctggttccc cgaggaaggc ggcctgaatc tgcaggattg gaagagagtg      180

ggcagagaaa tgaagaagta cgccgctgag cacggcaccg acagcatccc caagcaggct      240

tatcctatct ggctgcaact gagagagatc ctgacagagc aatctgacct ggtgctgctg      300

agcgccgagg ccaagtccgt gacagaggaa gaactggaag aaggcctgac aggactgctg      360

agcgccagca gccaggagaa gacctacggc acaagaggca ccgcctatgc cgaaatcgac      420

accgaggtgg ataagctgag cgagcacatc tacgacgagc cctacgagga gaaggaaaag      480

gccgacaaga acgaggagaa ggaccacgtg cggaaggtca agaagatcgt gcaaagaaag      540

gaaaatagcg agcataagag aaaggagaaa gatcagaagg ccttcctggc aaccgactgg      600

aacaacgacg acctgagccc tgaggactgg gacgacctgg aagagcaggc cgcccactac      660

cacgatgacg acgaactgat cctgcctgtg aagagaaagg tggacaagaa gaagccgctc      720

gccctgaggc ggaaacctct gcccccggtt ggcttcgccg gagccatggc cgaggctaga      780

gagaagggcg atctgacctt cacatttccc gtggttttca tgggagaatc cgacgacgat      840

gatacccctg tgtgggaacc tctgcccctg aagacactga aggaactgca gtctgccgtg      900

cggaccatgg gccctagcgc cccttacacc ctccaggtgg tggacatggt tgcctctcag      960

tggctgacac ctagcgattg gcaccaaacc gccagagcca ccctgtctcc tggggactac     1020

gtgctgtggc ggaccgagta cgaggagaag agcaaggaaa ccgtgcagaa gaccgctggc     1080

aagcggaaag gcaaggtgag cctggatatg ctgctgggca caggtcagtt cctgagccct     1140

tcttctcaga tcaagctttc taaagatgtg ctgaaggatg tgaccaccaa cgccgtcctg     1200

gcctggagag ccatccctcc tccaggcgtc aaaaagacag tgctggccgg actcaagcag     1260

ggaaatgagg aaagctacga gacattcatc agcagactgg aagaggccgt gtacagaatg     1320

atgcctagag gagaaggcag cgacatcctg atcaagcagc tggcttggga gaacgctaat     1380

tctctgtgcc aggacctgat ccggcctatg cggaagaccg gcaccatgca ggactacatc     1440

agagcctgtc tggatgcctc ccctgccgtg gtgcagggca tggcctacgc cgccgcaatg     1500

agaggacaaa agtacagcac cttcgtgaaa cagacatacg gcggcggaaa aggcggacag     1560

ggctctgaag gccctgtgtg cttcagctgc ggcaaaacag gtcacattaa gcgggattgc     1620

aaggaagaga aaggaagcaa gcgcgctcct cctggactgt gtcctagatg caagaaaggc     1680

taccactgga agagcgagtg caagagcaag ttcgacaagg acggcaaccc tctgccacca     1740

ctggaaacta acgccgaaaa cagcaaaaac cccacacaga aaggcgacaa aggaaaggac     1800

agcggactga accccgaagc ccctcctttc accatccacg acctgccacg aggcacccca     1860

ggcagtgccg gcttggacct gagcagccag aaagacctga tcctgtctct ggaagacggc     1920

gtgtccctgg tgccaaccct ggtgaagggc accctgcccg agggcaccac gggactgatc     1980

atcggcagat ccagcaacta caagaaaggc ctggaggtgc tgcccggcgt gatcgactcc     2040

gacttccagg gcgaaattaa ggtcatggta aaggccgcta agaacgccgt gatcatccac     2100

aagggcgagc ggatcgcgca gctgctgctg ctgccttatc tgaaactgcc taaccctatc     2160

atcaaggagg aaagaggcag cgagggattt ggcagcacct cccacgtgca ctgggtgcag     2220

gagatcagcg acagcagacc catgctgcac atcagcctga acggcagaag attcctgggc     2280

ctgctggaca ccggggccga taagacctgc atcgccggca gagattggcc cgccaactgg     2340

cctattcacc agaccgagag cagcctgcag ggcttgggaa tggcttgtgg cgtggctaga     2400

agctctcagc ctctgagatg gcagcacgag gataagtctg gcattatcca tcctttcgtg     2460

atccccacat tgccttttac cctctggggc cgggacatca tgaaagagat aaaggtgcgg     2520

ctgatgaccg atagcccaga cgacagccag gatctgacat ctctgtacgg cttaggtgcc     2580

gacctggtgc tgctgagcgc cgagggcggc agcccaaaga agaagcggaa ggtctctaga     2640

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     2700

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     2760

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     2820

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     2880

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     2940

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     3000

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     3060

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     3120

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     3180

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     3240

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     3300

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     3360

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     3420

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     3480

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     3540

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     3600

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     3660

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     3720

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     3780

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     3840

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     3900

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     3960

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     4020

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     4080

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     4140

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     4200

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     4260

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     4320

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     4380

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     4440

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     4500

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     4560

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     4620

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     4680

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     4740

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     4800

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     4860

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     4920

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     4980

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     5040

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     5100

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     5160

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     5220

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     5280

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     5340

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     5400

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     5460

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     5520

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     5580

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        5637


<210>  953
<211>  5811
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP44 plasmid sequence

<400>  953
atgggccagg agctgtccca gcacgagcgg tacgtggagc agctgaagca agcccttaaa       60

acaagaggcg tgaaggtgaa atacgccgac ctgctgaagt tcttcgattt tgtgaaggat      120

acctgccctt ggttccctca ggagggcacc atcgacatca agagatggcg cagagtgggc      180

gactgcttcc aagattacta caacaccttc ggacctgaga aagtgcctgt gaccgccttc      240

agctactgga acctgatcaa ggaactgatc gacaaaaagg aagtgaaccc acaggtgatg      300

gctgctgtcg cccagaccga ggaaatcctg aagagcaaca gccagacaga cctgaccaag      360

accagccaga accctgacct ggatctgatc agcctggaca gcgatgatga gggcgccaag      420

tccagcagcc tgcaggacaa gggcctgagc agcaccaaaa agcctaagcg gttccccgtc      480

ctgctgaccg cccagacaag caaggaccca gaggatccta acccaagcga ggtggactgg      540

gacggcctgg aggacgaggc cgctaagtac cacaaccctg actggccccc cttcctgaca      600

agacctccac cttacaacaa ggctacccct agcgccccta ccgtgatggc cgtggtgaac      660

cctaaagagg aactgaaaga aaagatcgcc cagctggaag agcagatcaa actggaagag      720

ctgcaccagg ccctgatttc taagctgcaa aagctgaaaa ccggcaacga gacagtcact      780

caccctgata cagccggagg cctgagcaga acaccacatt ggcccggcca gcacatccct      840

aagggcaagt gctgcgccag ccgggaaaag gaagagcaga tccccaagga tatcttccct      900

gtgaccgaaa ccgttgacgg acagggccag gcatggagac accacaatgg cttcgacttc      960

gccgtgatca aggaactgaa gacagccgcc tctcaatacg gcgccaccgc accttacacc     1020

ctggctatcg tggaatccgt cgccgacaac tggctgaccc caaccgactg gaataccctg     1080

gtgcgggccg tgctgtctgg cggcgaccac ctgctctgga agtctgagtt cttcgagaac     1140

tgtagggaca ccgctaagcg gaaccagcag gccggcaatg gatgggattt tgacatgctg     1200

accggcagcg gcaactacag ctctacagac gcccaaatgc agtacgaccc tggcctgttc     1260

gcccagattc aggccgctgc cacaaaggcc tggcggaagc tgcccgtgaa gggggatccc     1320

ggcgccagcc tgaccggcgt gaagcagggc cccgatgagc ctttcgccga cttcgtgcat     1380

agactgatca ccacagccgg cagaatcttc ggctccgccg aagccggcgt ggactacgtg     1440

aagcagctgg cttacgagaa cgccaaccct gcctgccagg ccgcaatcag accctataga     1500

aagaagacag atctgaccgg ctacatccgg ctgtgcagcg acatcggccc ttcctatcag     1560

cagggactgg ctatggccgc tgcctttagc ggccagaccg tgaaggactt cctgaacaac     1620

aagaacaagg aaaagggcgg atgttgtttt aagtgcggca agaaaggaca ctttgccaaa     1680

aactgccacg agcacgccca caacaacgcc gagcccaagg tgcccggcct gtgtcctcgg     1740

tgcaagagag gcaagcactg ggccaatgag tgcaagtcca agacagataa ccagggaaat     1800

ccaatccccc cccatcaggg aaatggtgct tctcctagac ctagaaacaa gctgatgggc     1860

caaagcgccc tgttccagcc taccaagaca acccacttca aggcctacca gagccacccc     1920

agaaagtgca gaatcggccc tctgttccac ctgccccaca gcatcaacgc ctgaaatggg     1980

gccccaagcg ttaagcactg gaatatatgg accactgcct cccaacactt ttggattaat     2040

cctaggccga agtagcatta ctatgaaggg tctacaagtt tatccaggag taattgataa     2100

tgactatacc ggagaaatta aaattatggc aaaagctgtt aacaatattg ttactgtctc     2160

tcaaggcaac agaatagctc aattaatcct cctgcctctg atcgagacag acaataaggt     2220

acaacaacct tatagaggac aaggaagttt tggatcctca gacatatatt gggtccagcc     2280

tatcacctgt cagaagcctt ctctgaccct gtggctggac gacaagatgt tcaccggcct     2340

catcgacacc ggcgccgacg tgacaatcat caagctggaa gattggcctc caaattggcc     2400

cattacagat accctgacca acctgagagg catcggacag tccaacaacc ccaagcagag     2460

cagcaagtac ctgacatggc gggacaagga gaacaacagc ggcctgatca aaccttttgt     2520

gatccccaat ctgcctgtga acctgtgggg aagagatctg ctgtctcaga tgaagatcat     2580

gatgtgcagc ccaaacgaca tcgtgaccgc ccagatgctg gctcaaggct acagccccgg     2640

caaaggcctg ggcaagaaag agaatggaat cctgcaccct atccctaacc agggccagag     2700

caacaagaag ggcttcggca acttctgact gcggccattg acatacttgg tgccccacag     2760

gtgatggctg ctgtcgccgg cggcagccca aagaagaagc ggaaggtctc tagacaagag     2820

atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac aaagaaggcc     2880

ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga cctgagagag     2940

cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag caacaccagc     3000

agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc catcctgcac     3060

gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt tgctcagcct     3120

gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa gggcaatctg     3180

accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta caagctggaa     3240

caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa cgtggccgag     3300

cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga tgaggccgtg     3360

acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat ccacgtgacc     3420

aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag atacgcctct     3480

ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag cttcctgagc     3540

aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca gaagagactg     3600

gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt gaccctgcct     3660

cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc cagagtgaga     3720

atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga cgccaagcct     3780

ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc caatgaagtg     3840

gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa agaggatggc     3900

aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag gccttacctg     3960

agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct gggcgacctg     4020

ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga tgaggcctgg     4080

gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga agaggaaaga     4140

aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc caaggccagc     4200

tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg cgagctgaag     4260

ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc cgagaacagc     4320

atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg gcagaaagac     4380

ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg caagctgcgg     4440

ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt gatcaacaaa     4500

aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc caacctgatt     4560

atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa cgatctgctg     4620

agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa aaccctgtac     4680

aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt cgagagaaga     4740

gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga ccggggcgag     4800

aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag cagattcaag     4860

gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa agagaagcag     4920

aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata ctctaggaag     4980

tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc cagagatctg     5040

ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag cagaggcttc     5100

ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat ggaagattgg     5160

ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa aacactggcc     5220

cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc cgactacgac     5280

agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat caacggcaaa     5340

gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca gaacgtcgtg     5400

aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa cgacatcagc     5460

agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag gtttagccac     5520

agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca cgccgatgaa     5580

caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga gtacaagaag     5640

taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga aacctggcag     5700

agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag tccaaaaaag     5760

aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg a              5811


<210>  954
<211>  4779
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP45 plasmid sequence

<400>  954
atgggcaact ctcctagcta caatccccct gccggcatct ccccatctga ctggctgaac       60

ctgctgcagt ccgcccagcg cctgaatcca aggcctagcc catccgactt cacagatctg      120

aagaactata tccactggtt tcacaagacc cagaagaagc cttggacctt cacaagcgga      180

ggaccaacat cctgcccacc aggcagattt ggaagggtgc cactggtgct ggccaccctg      240

aacgaggtgc tgtccaatga gggaggagca cctggagcct ctgccccaga ggagcagcct      300

ccaccctacg accctccagc catcctgccc atcatctccg agggaaacag gaataggcac      360

agggcatggg cactgaggga gctgcaggat atcaagaagg agatcgagaa taaggcccct      420

ggctctcaag tgtggatcca gacactgcgg ctggccatcc tgcaggcaga cccaacccct      480

gcagatctgg agcagctgtg ccagtacatc gccagccctg tggaccagac cgcccacatg      540

acatccctga ccgcagcaat cgcagcagca gaggcagcaa cacccagcag agtgctgacc      600

cctaagaccg gcacactgac ccagcagtct gcccagccaa acgcaggcga tctgaggagc      660

cagtatcaga atctgtggct gcaggccggc aagatctccc tgctggtgct gcagctgcag      720

ccctggtcta ccatcgtgca gggacctgca gagagctccg tggagtttgt gaaccgcctg      780

cagatctccc tggccgacaa cctgccagat ggcgtgctgc ggaatcccct gctgacacct      840

ctggtcatgc agatgctgac cgagtctgtg agcaagttct gcaggggaga ggccagcgga      900

aggggaggag ccaagacagc aggactgaga accatcggac cacctaggat gaagcagcct      960

gccctgctgg tgcacacccc aggaccaaag atgcctggac cacgccagcc agcacctaag     1020

aggccaccac ctggaccttg ctacagatgt ctgaaggagg gacactgggc cagggactgc     1080

ccaacaaagg caaccggccc accacctgga ccatgcccca tctgtaagga cccaagccac     1140

tggaagcgcg attgtcccac actgaagtcc aagaattaat agagggggga cttagcgccc     1200

cccaaaccat aacacctata acagattctc ttagtgaggc cgaattagaa tgcttactct     1260

ctattcctct ggcccggagc cgccctagcg tggccgtgta cctgagcggc ccttggctgc     1320

aaccttctca gaaccaggcc ctgatgctgg ttgatacagg cgccgagaac accgtgctgc     1380

ctcagaattg gctggtgcgg gactacccca gaatccctgc cgctgtgctg ggagccggag     1440

gcgtgtcccg gaacagatac aactggctgc agggccctct tacactggct ctgaaacctg     1500

aaggcccatt catcaccatc ccaaagatcc tggtcgacac cttcgacaag tggcagatcc     1560

tgggcagaga tgtgctgagc agactgcagg ccagcatcag catccccgag gaagtgcggc     1620

cccccgtggt gggcgtcttg gatgcccccc cgagccacat tggattagaa catctgcccc     1680

ccccacctga ggtgcctcaa ttccctttaa actagaggtg ccccagccat cctgcccatc     1740

atctccggcg gcagcccaaa gaagaagcgg aaggtctcta gacaagagat caagagaatc     1800

aacaagatca gaaggagact ggtcaaggac agcaacacaa agaaggccgg caagacaggc     1860

cccatgaaaa ccctgctcgt cagagtgatg acccctgacc tgagagagcg gctggaaaac     1920

ctgagaaaga agcccgagaa catccctcag cctatcagca acaccagcag ggccaacctg     1980

aacaagctgc tgaccgacta caccgagatg aagaaagcca tcctgcacgt gtactgggaa     2040

gagttccaga aagaccccgt gggcctgatg agcagagttg ctcagcctgc cagcaagaag     2100

atcgaccaga acaagctgaa gcccgagatg gacgagaagg gcaatctgac cacagccggc     2160

tttgcctgct ctcagtgtgg ccagcctctg ttcgtgtaca agctggaaca ggtgtccgag     2220

aaaggcaagg cctacaccaa ctacttcggc agatgtaacg tggccgagca cgagaagctg     2280

attctgctgg cccagctgaa acctgagaag gactctgatg aggccgtgac ctacagcctg     2340

ggcaagtttg gacagagagc cctggacttc tacagcatcc acgtgaccaa agaaagcaca     2400

caccccgtga agcccctggc tcagatcgcc ggcaatagat acgcctctgg acctgtgggc     2460

aaagccctgt ccgatgcctg catgggaaca atcgccagct tcctgagcaa gtaccaggac     2520

atcatcatcg agcaccagaa ggtggtcaag ggcaaccaga agagactgga aagcctgagg     2580

gagctggccg gcaaagagaa cctggaatac cccagcgtga ccctgcctcc tcagcctcac     2640

acaaaagaag gcgtggacgc ctacaacgaa gtgatcgcca gagtgagaat gtgggtcaac     2700

ctgaacctgt ggcagaagct gaaactgtcc agggacgacg ccaagcctct gctgagactg     2760

aagggcttcc ctagcttccc tctggtggaa agacaggcca atgaagtgga ttggtgggac     2820

atggtctgca acgtgaagaa gctgatcaac gagaagaaag aggatggcaa ggttttctgg     2880

cagaacctgg ccggctacaa gagacaagaa gccctgaggc cttacctgag cagcgaagag     2940

gaccggaaga agggcaagaa gttcgccaga taccagctgg gcgacctgct gctgcacctg     3000

gaaaagaagc acggcgagga ctggggcaaa gtgtacgatg aggcctggga gagaatcgac     3060

aagaaggtgg aaggcctgag caagcacatt aagctggaag aggaaagaag gagcgaggac     3120

gcccaatcta aagccgctct gaccgattgg ctgagagcca aggccagctt tgtgatcgag     3180

ggcctgaaag aggccgacaa ggacgagttc tgcagatgcg agctgaagct gcagaagtgg     3240

tacggcgatc tgagaggcaa gcccttcgcc attgaggccg agaacagcat cctggacatc     3300

agcggcttca gcaagcagta caactgcgcc ttcatttggc agaaagacgg cgtcaagaaa     3360

ctgaacctgt acctgatcat caattacttc aaaggcggca agctgcggtt caagaagatc     3420

aaacccgagg ccttcgaggc taacagattc tacaccgtga tcaacaaaaa gtccggcgag     3480

atcgtgccca tggaagtgaa cttcaacttc gacgacccca acctgattat cctgcctctg     3540

gccttcggca agagacaggg cagagagttc atctggaacg atctgctgag cctggaaacc     3600

ggctctctga agctggccaa tggcagagtg atcgagaaaa ccctgtacaa caggagaacc     3660

agacaggacg agcctgctct gtttgtggcc ctgaccttcg agagaagaga ggtgctggac     3720

agcagcaaca tcaagcccat gaacctgatc ggcgtggacc ggggcgagaa tatccctgct     3780

gtgatcgccc tgacagaccc tgaaggatgc ccactgagca gattcaagga ctccctgggc     3840

aaccctacac acatcctgag aatcggcgag agctacaaag agaagcagag gacaatccag     3900

gccaagaaag aggtggaaca gagaagagcc ggcggatact ctaggaagta cgccagcaag     3960

gccaagaatc tggccgacga catggtccga aacaccgcca gagatctgct gtactacgcc     4020

gtgacacagg acgccatgct gatcttcgag aatctgagca gaggcttcgg ccggcagggc     4080

aagagaacct ttatggccga gaggcagtac accagaatgg aagattggct cacagctaaa     4140

ctggcctacg agggactgag caagacctac ctgtccaaaa cactggccca gtatacctcc     4200

aagacctgca gcaattgcgg cttcaccatc accagcgccg actacgacag agtgctggaa     4260

aagctcaaga aaaccgccac cggctggatg accaccatca acggcaaaga gctgaaggtt     4320

gagggccaga tcacctacta caacaggtac aagaggcaga acgtcgtgaa ggatctgagc     4380

gtggaactgg acagactgag cgaagagagc gtgaacaacg acatcagcag ctggacaaag     4440

ggcagatcag gcgaggctct gagcctgctg aagaagaggt ttagccacag acctgtgcaa     4500

gagaagttcg tgtgcctgaa ctgcggcttc gagacacacg ccgatgaaca ggctgccctg     4560

aacattgcca gaagctggct gttcctgaga agccaagagt acaagaagta ccagaccaac     4620

aagaccaccg gcaacaccga caagagggcc tttgtggaaa cctggcagag cttctacaga     4680

aaaaagctga aagaagtctg gaagcccgcc gtgactagtc caaaaaagaa gagaaaggta     4740

gccctcgagt acccatatga tgtccctgac tacgcttga                            4779


<210>  955
<211>  5078
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP46 plasmid sequence

<400>  955
atgggtcaga ttttcagcag aagcgcctcc cctattccta gacctccacg gggcctggcc       60

gcccaccact ggctgaattt cctgcaggcc gcttatagac tggagcctgg accttccagc      120

tacgacttcc accagctgaa gaaattcctg aagatcgccc tggaaacccc tgccagaatc      180

tgccctatca actacagcct gctggcctcc ctgctgccca agggctaccc tggcagagtg      240

aacgagatcc ttcatatcct gatccagaca caggctcaga tcccctctag gcccgctcca      300

cctcctccaa gcagcccaac ccacgatcct cctgatagcg accctcagat ccccccacca      360

tacgtggagc ccaccgcccc tcaagtgctg ccagtgatgc acccccacgg cgcccctcct      420

aatcacagac cttggcagat gaaagacctg caggccatca agcaggaagt gtcccaggcc      480

gctcctggca gcccccaatt tatgcagacc atcagactcg ccgttcagca gttcgacccc      540

acagccaagg atctgcagga cctgctgcag tacctgtgta gcagcctggt cgccagcctg      600

caccatcagc aactggattc tctgatcagc gaggccgaga caagaggcat caccggctac      660

aaccctctgg ccggccccct gcgggtgcag gcaaacaacc cccagcagca ggggctgcgg      720

agagagtacc agcagctgtg gctggctgct ttcgccgcac tgcctggaag cgccaaagat      780

ccatcttggg cctctatcct gcagggcctg gaagaacctt accacgcctt tgtggaaaga      840

ctgaacatcg ccctggacaa cggcctgcct gagggcaccc ctaaggaccc catcctgaga      900

tctctggcct acagcaacgc caacaaggaa tgtcagaagc tgctgcaagc cagaggccac      960

accaacagcc ccctgggcga catgctgcgc gcctgccaga cctggacccc taaggacaag     1020

accaaggtgc tggtggtgca gcctaagaag cctcccccta atcagccctg cttccggtgc     1080

ggcaaggccg gacactggag ccgggactgc acccagcctc ggcctccacc gggaccttgt     1140

cctctgtgcc aagaccccac acactggaag agagattgcc cccgcctaaa gcccactatc     1200

ccagaaccag agccagagga agatgccctc ctattagacc tccccgctga cattccacac     1260

ccaaaaaact ccataggggg ggaggtttaa cctctcctcc taccctgcag caggtgttcc     1320

tgaatcaaga tcctgccagc atcctgcctg tgatccccct cgaccccgct agaagacctg     1380

tgatcaaggc ccaggtggac acacagacct cccaccccaa aacaatcgag gccctgctgg     1440

acaccggcgc tgatatgaca gtgctgccaa tcgccctgtt cagcagcaac acccctctga     1500

aaaacaccag cgtgctcgga gccggcggac agacccagga ccacttcaag ctgacaagcc     1560

tgcctgtcct gatccggctg cccttcagaa ccacacctat cgtgctgacc agctgcctgg     1620

tggacacaaa gaacaactgg gccatcatcg gcagggacgc cctgcaacag tgccagggcg     1680

tgctgtacct gccagaggcc aagggccccc ccgttatcct gcctatccag gcccctgccg     1740

tgctgggcct ggaacacctg ccaagacccc cccagatcag ccaatttcct ctgaaccaga     1800

acgccagcag accatgtaat acctggtccg gcagaccttg gcggcaggcc atttctaacc     1860

ccacccccgg ccaggagatc acccagtaca gccagctgaa gcggcctatg gaacctggag     1920

attctagcac cacctgcggc cctctgacac tgtgaccata gacctctcat catcttcccc     1980

cgggccccct gacttgtcca gcctgccaac cacacggtgc ccctcaagtg ctgccagtga     2040

tgcacggcgg cagcccaaag aagaagcgga aggtctctag acaagagatc aagagaatca     2100

acaagatcag aaggagactg gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc     2160

ccatgaaaac cctgctcgtc agagtgatga cccctgacct gagagagcgg ctggaaaacc     2220

tgagaaagaa gcccgagaac atccctcagc ctatcagcaa caccagcagg gccaacctga     2280

acaagctgct gaccgactac accgagatga agaaagccat cctgcacgtg tactgggaag     2340

agttccagaa agaccccgtg ggcctgatga gcagagttgc tcagcctgcc agcaagaaga     2400

tcgaccagaa caagctgaag cccgagatgg acgagaaggg caatctgacc acagccggct     2460

ttgcctgctc tcagtgtggc cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga     2520

aaggcaaggc ctacaccaac tacttcggca gatgtaacgt ggccgagcac gagaagctga     2580

ttctgctggc ccagctgaaa cctgagaagg actctgatga ggccgtgacc tacagcctgg     2640

gcaagtttgg acagagagcc ctggacttct acagcatcca cgtgaccaaa gaaagcacac     2700

accccgtgaa gcccctggct cagatcgccg gcaatagata cgcctctgga cctgtgggca     2760

aagccctgtc cgatgcctgc atgggaacaa tcgccagctt cctgagcaag taccaggaca     2820

tcatcatcga gcaccagaag gtggtcaagg gcaaccagaa gagactggaa agcctgaggg     2880

agctggccgg caaagagaac ctggaatacc ccagcgtgac cctgcctcct cagcctcaca     2940

caaaagaagg cgtggacgcc tacaacgaag tgatcgccag agtgagaatg tgggtcaacc     3000

tgaacctgtg gcagaagctg aaactgtcca gggacgacgc caagcctctg ctgagactga     3060

agggcttccc tagcttccct ctggtggaaa gacaggccaa tgaagtggat tggtgggaca     3120

tggtctgcaa cgtgaagaag ctgatcaacg agaagaaaga ggatggcaag gttttctggc     3180

agaacctggc cggctacaag agacaagaag ccctgaggcc ttacctgagc agcgaagagg     3240

accggaagaa gggcaagaag ttcgccagat accagctggg cgacctgctg ctgcacctgg     3300

aaaagaagca cggcgaggac tggggcaaag tgtacgatga ggcctgggag agaatcgaca     3360

agaaggtgga aggcctgagc aagcacatta agctggaaga ggaaagaagg agcgaggacg     3420

cccaatctaa agccgctctg accgattggc tgagagccaa ggccagcttt gtgatcgagg     3480

gcctgaaaga ggccgacaag gacgagttct gcagatgcga gctgaagctg cagaagtggt     3540

acggcgatct gagaggcaag cccttcgcca ttgaggccga gaacagcatc ctggacatca     3600

gcggcttcag caagcagtac aactgcgcct tcatttggca gaaagacggc gtcaagaaac     3660

tgaacctgta cctgatcatc aattacttca aaggcggcaa gctgcggttc aagaagatca     3720

aacccgaggc cttcgaggct aacagattct acaccgtgat caacaaaaag tccggcgaga     3780

tcgtgcccat ggaagtgaac ttcaacttcg acgaccccaa cctgattatc ctgcctctgg     3840

ccttcggcaa gagacagggc agagagttca tctggaacga tctgctgagc ctggaaaccg     3900

gctctctgaa gctggccaat ggcagagtga tcgagaaaac cctgtacaac aggagaacca     3960

gacaggacga gcctgctctg tttgtggccc tgaccttcga gagaagagag gtgctggaca     4020

gcagcaacat caagcccatg aacctgatcg gcgtggaccg gggcgagaat atccctgctg     4080

tgatcgccct gacagaccct gaaggatgcc cactgagcag attcaaggac tccctgggca     4140

accctacaca catcctgaga atcggcgaga gctacaaaga gaagcagagg acaatccagg     4200

ccaagaaaga ggtggaacag agaagagccg gcggatactc taggaagtac gccagcaagg     4260

ccaagaatct ggccgacgac atggtccgaa acaccgccag agatctgctg tactacgccg     4320

tgacacagga cgccatgctg atcttcgaga atctgagcag aggcttcggc cggcagggca     4380

agagaacctt tatggccgag aggcagtaca ccagaatgga agattggctc acagctaaac     4440

tggcctacga gggactgagc aagacctacc tgtccaaaac actggcccag tatacctcca     4500

agacctgcag caattgcggc ttcaccatca ccagcgccga ctacgacaga gtgctggaaa     4560

agctcaagaa aaccgccacc ggctggatga ccaccatcaa cggcaaagag ctgaaggttg     4620

agggccagat cacctactac aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg     4680

tggaactgga cagactgagc gaagagagcg tgaacaacga catcagcagc tggacaaagg     4740

gcagatcagg cgaggctctg agcctgctga agaagaggtt tagccacaga cctgtgcaag     4800

agaagttcgt gtgcctgaac tgcggcttcg agacacacgc cgatgaacag gctgccctga     4860

acattgccag aagctggctg ttcctgagaa gccaagagta caagaagtac cagaccaaca     4920

agaccaccgg caacaccgac aagagggcct ttgtggaaac ctggcagagc ttctacagaa     4980

aaaagctgaa agaagtctgg aagcccgccg tgactagtcc aaaaaagaag agaaaggtag     5040

ccctcgagta cccatatgat gtccctgact acgcttga                             5078


<210>  956
<211>  5244
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP47 plasmid sequence

<400>  956
atgggcaata gctcctctac cccccctcca agcgccctga agaactccga tctgttcaag       60

accatgctga ggacacagta cagcggctcc gtgaagacac ggagaatcaa ccaggatatc      120

aagaagcagt atccactgtg gccagaccag ggaacctgcg caacaaagca ctgggagcag      180

gccgtgctga tccccctgga ctctgtgagc gaggagaccg ccaaggtgct gaatttcctg      240

cgggtgaaga tccaggccag aaagggagag accgcaaggc agatgaccgc acacacaatc      300

aagaagctga tcgtgggcac aatcgataag aacaagcagc agaccgagat cctgcagaag      360

acagacgaga gcgatgagga gatggacacc acaaatacca tgctgtttat cgcccgcaac      420

aagagggaga ggatcgcaca gcagcagcag gcagatctgg cagcacagca gcaggtgctg      480

ctgctgcaga gggagcagca gagggagcag agagagaagg atatcaagaa gcgggacgag      540

aagaagaaga agctgctgcc cgacaccaca cagaaggtgg agcagaccga tatcggagag      600

gccagctcct ctgacgcctc cgcccagaag ccaatctcta ccgacaacaa tcccgatctg      660

aaggtggacg gcgtgctgac aagaagccag cacaccacag tgccttccaa catcaccatc      720

aagaaggatg gcacatccgt gcagtaccag caccccatca ggaactatcc taccggcgag      780

ggcaatctga cagcccaggt gcggaaccct tttagaccac tggagctgca gcagctgagg      840

aaggactgcc ccgccctgcc tgagggcatc ccacagctgg ccgagtggct gacccagaca      900

atggccatct acaattgtga cgaggccgat gtggagcagc tggccagagt gatcttccca      960

acccctgtga ggcagatcgc aggcgtgatc aacggacacg cagcagcaaa taccgcagcc     1020

aagatccaga actacgtgac agcatgcagg cagcactatc cagccgtgtg cgattggggc     1080

accatccagg cctttacata caagccccct cagaccgccc acgagtatgt gaagcacgcc     1140

gagatcatct tcaagaacaa tagcggactg gagtggcagc acgcaaccgt gccttttatc     1200

aatatggtgg tgcagggcct gccacccaag gtgacacggt ccctgatgtc tggcaaccca     1260

gattggagca ccaagacaat cccacagatc atccccctga tgcagcacta cctgaatctg     1320

cagtccagac aggacgccaa gatcaagcag acccctctgg tgctgcagct ggccatgcca     1380

gcccagacaa tgaacggcaa taagggctac gtgggctcct atcctaccaa cgagccatac     1440

tattctttcc agcagcagca gaggccagca cccagagccc ctccaggcaa cgtgccttcc     1500

aatacctgct tcttttgtaa gcagccagga cactggaagg cagactgccc taataagaca     1560

aggaacctgc gcaatatggg caacatggga aggggaggaa gaatgggagg accaccttac     1620

cggagccagc cttatccagc ctttatccag ccaccccaga atcaccagaa ccagtataat     1680

ggcaggatgg atcgctctca gctgcaggcc agcgcccagg agtggctgcc aggaacctac     1740

cctgcatgag acccaatcga ttgcccctat gagaagagcg gcacaaagac cacacaggac     1800

gtgatcacca caaagaatgc cgagatcatg gtgaccgtga accacacaaa gatcccaatg     1860

ctggtggata ccggcgcctg tctgacagca atcggaggag cagcaaccgt ggtgccagac     1920

ctgaagctga ccaacacaga gatcatcgca gtgggaatct ctgccgagcc cgtgcctcac     1980

gtgctggcca agccaaccaa gatccagatc gagaacacaa atatcgatat cagcccttgg     2040

tacaatccag accagacctt ccacatcctg ggccgcgaca cactgtctaa gatgcgggcc     2100

atcgtgagct ttgagaagaa cggcgagatg accgtgctgc tgcctccaac atatcacaag     2160

cagctgtcct gtcagaccaa gggtgccgca aggcagatga ccgcacacac aggcggcagc     2220

ccaaagaaga agcggaaggt ctctagacaa gagatcaaga gaatcaacaa gatcagaagg     2280

agactggtca aggacagcaa cacaaagaag gccggcaaga caggccccat gaaaaccctg     2340

ctcgtcagag tgatgacccc tgacctgaga gagcggctgg aaaacctgag aaagaagccc     2400

gagaacatcc ctcagcctat cagcaacacc agcagggcca acctgaacaa gctgctgacc     2460

gactacaccg agatgaagaa agccatcctg cacgtgtact gggaagagtt ccagaaagac     2520

cccgtgggcc tgatgagcag agttgctcag cctgccagca agaagatcga ccagaacaag     2580

ctgaagcccg agatggacga gaagggcaat ctgaccacag ccggctttgc ctgctctcag     2640

tgtggccagc ctctgttcgt gtacaagctg gaacaggtgt ccgagaaagg caaggcctac     2700

accaactact tcggcagatg taacgtggcc gagcacgaga agctgattct gctggcccag     2760

ctgaaacctg agaaggactc tgatgaggcc gtgacctaca gcctgggcaa gtttggacag     2820

agagccctgg acttctacag catccacgtg accaaagaaa gcacacaccc cgtgaagccc     2880

ctggctcaga tcgccggcaa tagatacgcc tctggacctg tgggcaaagc cctgtccgat     2940

gcctgcatgg gaacaatcgc cagcttcctg agcaagtacc aggacatcat catcgagcac     3000

cagaaggtgg tcaagggcaa ccagaagaga ctggaaagcc tgagggagct ggccggcaaa     3060

gagaacctgg aataccccag cgtgaccctg cctcctcagc ctcacacaaa agaaggcgtg     3120

gacgcctaca acgaagtgat cgccagagtg agaatgtggg tcaacctgaa cctgtggcag     3180

aagctgaaac tgtccaggga cgacgccaag cctctgctga gactgaaggg cttccctagc     3240

ttccctctgg tggaaagaca ggccaatgaa gtggattggt gggacatggt ctgcaacgtg     3300

aagaagctga tcaacgagaa gaaagaggat ggcaaggttt tctggcagaa cctggccggc     3360

tacaagagac aagaagccct gaggccttac ctgagcagcg aagaggaccg gaagaagggc     3420

aagaagttcg ccagatacca gctgggcgac ctgctgctgc acctggaaaa gaagcacggc     3480

gaggactggg gcaaagtgta cgatgaggcc tgggagagaa tcgacaagaa ggtggaaggc     3540

ctgagcaagc acattaagct ggaagaggaa agaaggagcg aggacgccca atctaaagcc     3600

gctctgaccg attggctgag agccaaggcc agctttgtga tcgagggcct gaaagaggcc     3660

gacaaggacg agttctgcag atgcgagctg aagctgcaga agtggtacgg cgatctgaga     3720

ggcaagccct tcgccattga ggccgagaac agcatcctgg acatcagcgg cttcagcaag     3780

cagtacaact gcgccttcat ttggcagaaa gacggcgtca agaaactgaa cctgtacctg     3840

atcatcaatt acttcaaagg cggcaagctg cggttcaaga agatcaaacc cgaggccttc     3900

gaggctaaca gattctacac cgtgatcaac aaaaagtccg gcgagatcgt gcccatggaa     3960

gtgaacttca acttcgacga ccccaacctg attatcctgc ctctggcctt cggcaagaga     4020

cagggcagag agttcatctg gaacgatctg ctgagcctgg aaaccggctc tctgaagctg     4080

gccaatggca gagtgatcga gaaaaccctg tacaacagga gaaccagaca ggacgagcct     4140

gctctgtttg tggccctgac cttcgagaga agagaggtgc tggacagcag caacatcaag     4200

cccatgaacc tgatcggcgt ggaccggggc gagaatatcc ctgctgtgat cgccctgaca     4260

gaccctgaag gatgcccact gagcagattc aaggactccc tgggcaaccc tacacacatc     4320

ctgagaatcg gcgagagcta caaagagaag cagaggacaa tccaggccaa gaaagaggtg     4380

gaacagagaa gagccggcgg atactctagg aagtacgcca gcaaggccaa gaatctggcc     4440

gacgacatgg tccgaaacac cgccagagat ctgctgtact acgccgtgac acaggacgcc     4500

atgctgatct tcgagaatct gagcagaggc ttcggccggc agggcaagag aacctttatg     4560

gccgagaggc agtacaccag aatggaagat tggctcacag ctaaactggc ctacgaggga     4620

ctgagcaaga cctacctgtc caaaacactg gcccagtata cctccaagac ctgcagcaat     4680

tgcggcttca ccatcaccag cgccgactac gacagagtgc tggaaaagct caagaaaacc     4740

gccaccggct ggatgaccac catcaacggc aaagagctga aggttgaggg ccagatcacc     4800

tactacaaca ggtacaagag gcagaacgtc gtgaaggatc tgagcgtgga actggacaga     4860

ctgagcgaag agagcgtgaa caacgacatc agcagctgga caaagggcag atcaggcgag     4920

gctctgagcc tgctgaagaa gaggtttagc cacagacctg tgcaagagaa gttcgtgtgc     4980

ctgaactgcg gcttcgagac acacgccgat gaacaggctg ccctgaacat tgccagaagc     5040

tggctgttcc tgagaagcca agagtacaag aagtaccaga ccaacaagac caccggcaac     5100

accgacaaga gggcctttgt ggaaacctgg cagagcttct acagaaaaaa gctgaaagaa     5160

gtctggaagc ccgccgtgac tagtccaaaa aagaagagaa aggtagccct cgagtaccca     5220

tatgatgtcc ctgactacgc ttga                                            5244


<210>  957
<211>  4962
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP48 plasmid sequence

<400>  957
atgggccaga caatcacaac ccctctgagc ctgaccctgg accactggag tgaagtgcgg       60

gctagagccc acaaccaggg cgtggaagtc cggaaaaaaa agtggatcac cctgtgcgag      120

gccgagtggg tcatgatgaa cgtgggatgg cctagagagg gtacatttag cctggacaac      180

atcagccagg ttgagaaaaa gattttcgct cctggccctt acggccatcc tgaccaggtg      240

ccttacatca ccacatggcg gagcctggct accgacccac caagctgggt gcggcccttc      300

ctgcctcctc ccaagccccc cacccctctg cctcagcctc tgagccccca gccctctgcc      360

cctctgacca gctctctgta ccctgtgctg cctaagtccg atccccctaa acctcctgtt      420

ttacctcccg accctagcag cccactgatc gacctgctga cggaagaacc tcctccttat      480

cctggcggac atggcccccc accttctggc cctcggaccc caaccgcctc ccctatcgcc      540

tctagactga gagagcggag agaaaacccc gccgaagagt cccaagccct gcccctgaga      600

gagggcccta acaaccggcc tcagtactgg cccttcagcg ccagcgatct gtataactgg      660

aagtcccaca atcctccttt cagccaggat cctgtggccc tgacaaacct gatcgagtct      720

atcctggtga ctcaccagcc aacctgggat gactgccagc agctgctgca ggccctcctg      780

accggcgaag agagacagag agtgctgctg gaggccagaa agcaggtgcc tggagaggac      840

ggcaggccta cccagctgcc taatgtgatc gacgagacat tccccctgac cagaccaaat      900

tgggacttcg ccaccccagc tggcagagag cacctgcgcc tgtaccggca gcttctgctg      960

gccggactga gaggcgctgc cagaagacca accaacctgg ctcaggtgaa gcaggtcgtg     1020

cagggcaaag aggagacacc cgccgctttc ctggaacggc tgaaggaggc ctacagaatg     1080

tacacccctt acgaccccga agatccagga caggccgcca gcgtgatcct gagcttcatc     1140

taccagagca gccctgacat cagaaacaag ctgcagcggc tggaaggcct gcagggcttc     1200

acactgagcg acctgctcaa ggaggccgag aagatctaca acaagcggga aacccctgag     1260

gaaagagaag agagattgtg gcagcggcaa gaggagcggg acaaaaagcg gcacaaggaa     1320

atgaccaagg tgctggctac cgtggtggcc cagaacagag ataaagacag agaggaatcg     1380

aagctgggcg accagagaaa gatccccctt ggcaaggacc aatgtgccta ctgcaaggaa     1440

aaaggccact gggtgaggga ctgtcccaag agacccagaa agaagcccgc aaacagcaca     1500

ctgctgaacc tgggcgatca ggagagccaa ggccaggacc cccctcctga gcctagaatc     1560

accctgaaga ttggaggcca gcctgtgacc tttctggtgg acaccggcgc ccaacactct     1620

gtgctgacca gacctgatgg ccccctcagc gatagaaccg ccctggtcca gggagctaca     1680

ggcagcaaga actacagatg gaccaccgac agaagggtgc agctggctac tggcaaggtg     1740

acacacagct ttctgtacgt gcccgagtgc ccttaccccc tcctgggcag agatctgttg     1800

acaaagctga aggcccaaat ccacttcacc ggagagggcg ctaatgtggt gggccccaag     1860

ggcctgcctc ttcaggtgct gacactgcaa ctggaagagg gtgccagctc tctgtaccct     1920

gtgctgcctg gcggcagccc aaagaagaag cggaaggtct ctagacaaga gatcaagaga     1980

atcaacaaga tcagaaggag actggtcaag gacagcaaca caaagaaggc cggcaagaca     2040

ggccccatga aaaccctgct cgtcagagtg atgacccctg acctgagaga gcggctggaa     2100

aacctgagaa agaagcccga gaacatccct cagcctatca gcaacaccag cagggccaac     2160

ctgaacaagc tgctgaccga ctacaccgag atgaagaaag ccatcctgca cgtgtactgg     2220

gaagagttcc agaaagaccc cgtgggcctg atgagcagag ttgctcagcc tgccagcaag     2280

aagatcgacc agaacaagct gaagcccgag atggacgaga agggcaatct gaccacagcc     2340

ggctttgcct gctctcagtg tggccagcct ctgttcgtgt acaagctgga acaggtgtcc     2400

gagaaaggca aggcctacac caactacttc ggcagatgta acgtggccga gcacgagaag     2460

ctgattctgc tggcccagct gaaacctgag aaggactctg atgaggccgt gacctacagc     2520

ctgggcaagt ttggacagag agccctggac ttctacagca tccacgtgac caaagaaagc     2580

acacaccccg tgaagcccct ggctcagatc gccggcaata gatacgcctc tggacctgtg     2640

ggcaaagccc tgtccgatgc ctgcatggga acaatcgcca gcttcctgag caagtaccag     2700

gacatcatca tcgagcacca gaaggtggtc aagggcaacc agaagagact ggaaagcctg     2760

agggagctgg ccggcaaaga gaacctggaa taccccagcg tgaccctgcc tcctcagcct     2820

cacacaaaag aaggcgtgga cgcctacaac gaagtgatcg ccagagtgag aatgtgggtc     2880

aacctgaacc tgtggcagaa gctgaaactg tccagggacg acgccaagcc tctgctgaga     2940

ctgaagggct tccctagctt ccctctggtg gaaagacagg ccaatgaagt ggattggtgg     3000

gacatggtct gcaacgtgaa gaagctgatc aacgagaaga aagaggatgg caaggttttc     3060

tggcagaacc tggccggcta caagagacaa gaagccctga ggccttacct gagcagcgaa     3120

gaggaccgga agaagggcaa gaagttcgcc agataccagc tgggcgacct gctgctgcac     3180

ctggaaaaga agcacggcga ggactggggc aaagtgtacg atgaggcctg ggagagaatc     3240

gacaagaagg tggaaggcct gagcaagcac attaagctgg aagaggaaag aaggagcgag     3300

gacgcccaat ctaaagccgc tctgaccgat tggctgagag ccaaggccag ctttgtgatc     3360

gagggcctga aagaggccga caaggacgag ttctgcagat gcgagctgaa gctgcagaag     3420

tggtacggcg atctgagagg caagcccttc gccattgagg ccgagaacag catcctggac     3480

atcagcggct tcagcaagca gtacaactgc gccttcattt ggcagaaaga cggcgtcaag     3540

aaactgaacc tgtacctgat catcaattac ttcaaaggcg gcaagctgcg gttcaagaag     3600

atcaaacccg aggccttcga ggctaacaga ttctacaccg tgatcaacaa aaagtccggc     3660

gagatcgtgc ccatggaagt gaacttcaac ttcgacgacc ccaacctgat tatcctgcct     3720

ctggccttcg gcaagagaca gggcagagag ttcatctgga acgatctgct gagcctggaa     3780

accggctctc tgaagctggc caatggcaga gtgatcgaga aaaccctgta caacaggaga     3840

accagacagg acgagcctgc tctgtttgtg gccctgacct tcgagagaag agaggtgctg     3900

gacagcagca acatcaagcc catgaacctg atcggcgtgg accggggcga gaatatccct     3960

gctgtgatcg ccctgacaga ccctgaagga tgcccactga gcagattcaa ggactccctg     4020

ggcaacccta cacacatcct gagaatcggc gagagctaca aagagaagca gaggacaatc     4080

caggccaaga aagaggtgga acagagaaga gccggcggat actctaggaa gtacgccagc     4140

aaggccaaga atctggccga cgacatggtc cgaaacaccg ccagagatct gctgtactac     4200

gccgtgacac aggacgccat gctgatcttc gagaatctga gcagaggctt cggccggcag     4260

ggcaagagaa cctttatggc cgagaggcag tacaccagaa tggaagattg gctcacagct     4320

aaactggcct acgagggact gagcaagacc tacctgtcca aaacactggc ccagtatacc     4380

tccaagacct gcagcaattg cggcttcacc atcaccagcg ccgactacga cagagtgctg     4440

gaaaagctca agaaaaccgc caccggctgg atgaccacca tcaacggcaa agagctgaag     4500

gttgagggcc agatcaccta ctacaacagg tacaagaggc agaacgtcgt gaaggatctg     4560

agcgtggaac tggacagact gagcgaagag agcgtgaaca acgacatcag cagctggaca     4620

aagggcagat caggcgaggc tctgagcctg ctgaagaaga ggtttagcca cagacctgtg     4680

caagagaagt tcgtgtgcct gaactgcggc ttcgagacac acgccgatga acaggctgcc     4740

ctgaacattg ccagaagctg gctgttcctg agaagccaag agtacaagaa gtaccagacc     4800

aacaagacca ccggcaacac cgacaagagg gcctttgtgg aaacctggca gagcttctac     4860

agaaaaaagc tgaaagaagt ctggaagccc gccgtgacta gtccaaaaaa gaagagaaag     4920

gtagccctcg agtacccata tgatgtccct gactacgctt ga                        4962


<210>  958
<211>  5061
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP49 plasmid sequence

<400>  958
atgggccaga ccgtgaccac acccctgtcc ctgacactgg gccactggaa ggacgtggag       60

cggatcgccc acaatcagtc tgtggatgtg aagaagcgga gatgggtgac cttctgcagc      120

gccgagtggc ccaccttcaa cgtgggctgg ccaagggacg gcaccttcaa ccgcgatctg      180

atcacacagg tgaagatcaa ggtgtttagc ccaggacctc acggacaccc agaccaggtg      240

ccttatatcg tgacctggga ggccctggcc ttcgatccac ctccatgggt gaagccattt      300

gtgcacccaa agccacctcc accactgcct ccatccgccc cttctctgcc actggagcca      360

cctcggtcca ccccaccaag aagctccctg tatcctgccc tgacaccatc tctgggcgcc      420

aagccaaagc cacaggtgct gtctgacagc ggaggacctc tgatcgacct gctgaccgag      480

gatcctccac cctacagaga tccaaggcct ccaccatccg acagggatgg aaacggagga      540

gaggcaacac cagcaggaga ggcccctgac ccatccccca tggcctctag actgaggggc      600

aggcgcgagc ctccagtggc agatagcacc acatcccagg cattcccact gagggcagga      660

ggaaatggcc agctgcagta ttggcccttt tctagctccg acctgtacaa ctggaagaac      720

aataacccat ccttctctga ggatcccggc aagctgaccg ccctgatcga gagcgtgctg      780

atcacccacc agcccacatg ggacgattgt cagcagctgc tgggcaccct gctgacaggc      840

gaggagaagc agcgggtgct gctggaggca aggaaggccg tgagaggcga cgatggcaga      900

cccacccagc tgcctaatga ggtggacgca gcatttccac tggagaggcc agactgggat      960

tataccacac aggccggcag gaaccacctg gtgcactaca ggcagctgct gctggccgga     1020

ctgcagaatg caggcaggtc ccctaccaac ctggccaagg tgaagggcat cacacagggc     1080

cctaatgaga gcccatccgc ctttctggag cgcctgaagg aggcctaccg gagatatacc     1140

ccctacgacc ctgaggatcc aggccaggag acaaacgtgt ctatgagctt catctggcag     1200

tctgccccag acatcggaag gaagctggag cgcctggagg acctgaagaa taagaccctg     1260

ggcgatctgg tgcgggaggc agagaagatc ttcaacaaga gagagacacc tgaggagagg     1320

gaggagcgga tcaggaggga gaccgaggag aaggaggagc ggagaaggac agaggacgag     1380

cagaaggaga aggagcggga tcgccggaga cacagagaga tgagcaagct gctggccacc     1440

gtggtgtccg gacagaagca ggacaggcag ggaggagaga ggcgccggtc tcagctggac     1500

cgcgatcagt gcgcctactg taaggagaag ggccactggg ccaaggattg ccccaagaag     1560

cctagaggcc caaggggccc taggccacag accagcctgc tgacactgga cgattgagga     1620

ggacagggac aggagccacc tccagagccc agaatcaccc tgaaggtcgg cggccagcct     1680

gtgacctttc tggtggacac aggcgcccag cacagcgtgc tgacccagaa tcccggccct     1740

ctgtctgata agagcgcctg ggtgcaggga gcaacaggcg gcaagcggta cagatggacc     1800

acagaccgga aggtgcacct ggccaccggc aaggtgacac acagctttct gcacgtgccc     1860

gactgtccat accccctgct gggcagagat ctgctgacca agctgaaggc acagatccac     1920

ttcgagggat ccggagcaca ggtcatggga ccaatgggac agcctctgca ggtgctgaca     1980

ctgaacatcg aggatgaggg tgccagctcc ctgtatcctg ccctgacagg cggcagccca     2040

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     2100

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     2160

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     2220

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     2280

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     2340

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     2400

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     2460

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     2520

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     2580

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     2640

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     2700

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2760

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2820

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2880

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2940

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     3000

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     3060

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     3120

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     3180

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     3240

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     3300

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     3360

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     3420

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     3480

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     3540

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     3600

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     3660

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3720

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3780

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3840

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3900

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3960

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     4020

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     4080

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     4140

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     4200

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     4260

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     4320

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     4380

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     4440

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     4500

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     4560

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     4620

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     4680

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4740

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4800

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4860

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4920

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4980

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     5040

gatgtccctg actacgcttg a                                               5061


<210>  959
<211>  4757
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP50 plasmid sequence

<400>  959
atggtgtctc tggacaggga tatggcaagg caggtgagcg gaggcaagag ggattaccca       60

gagctggaga agtgcatcaa gcacgcctgt aagatcaagg tgcggctgag aggagagcac      120

ctgaccgagg gcaactgcct gtggtgtctg aagacactgg actatatgtt cgaggatcac      180

aaggaggagc cctggaccaa ggtgaagttt agaacaatct ggcagaaggt gaagaacctg      240

acccctgagg agagcaataa gaaggacttc atgtccctgc aggccacact ggccggcctg      300

atgtgctgtc agatgggcat gaggccagag accctgcagg acgccatggc cacagtgatc      360

atgaaggatg gcctgctgga gcaggaggag aagaaggagg ataagcgcga gaaggaggag      420

agcgtgtttc caatcgtggt gcaggcagca ggaggccggt cctggaaggc cgtggactct      480

gtgatgttcc agcagctgca gaccgtggca atgcagcacg gactggtgag cgaggatttt      540

gagagacagc tggcctacta tgccaccaca tggacatcca aggacatcct ggaggtgctg      600

gccatgatgc ccggcaacag agcccagaag gagctgatcc agggcaagct gaatgaggag      660

gccgagaggt ggcggagaaa caatccacct ccaccagcag gaggaggact gaccgtggat      720

cagatcatgg gagtgggaca gacaaaccag gcagcagcac aggcaaatat ggaccaggcc      780

agacagatct gcctgcagtg ggtcatcaac gcactgaggg ccgtgagaca catggcacac      840

aggcccggca accctatgct ggtgaagcag aagaccaatg agccttacga ggacttcgcc      900

gccagactgc tggaggccat cgatgccgag ccagtgacac agcccatcaa ggactacctg      960

aagctgaccc tgagctatac aaatgcctcc gccgactgcc agaagcagat ggatagaacc     1020

ctgggacaga gggtgcagca ggcctccgtg gaggagaaga tgcaggcctg tagggatgtg     1080

ggctctgagg gctttaagat gcagctgctg gcccaggccc tgaggcctgg caagggcaag     1140

ggaaacggac agccacagcg gtgctacaat tgtggcaagc caggacacca ggcaaggcag     1200

tgcaggcagg gcatcatatg tcacaactgt ggaaagagag gacatatgca aaaagaatgc     1260

agaggaaaga gagacataag gggaaaacag cagggaaacg ggaggagggg gatacgtgtg     1320

gtgccgtccg ctcctcctat ggaataacaa gcgcccctcc aatggtgcag gtgcggattg     1380

gatctcagca gcgcaacctg ctgttcgaca ccggcgccga tagaaccatc gtccggtggc     1440

acgagggctc cggcaacccc gccggcagaa tcaaactgca aggcatcggc ggaatcgtgg     1500

aaggcgagaa gtggaacaac gtggagctgg aatacaaggg cgagacaaga aagggcacca     1560

tcgtggtgct gcctcagagc cctgtggagg tgctgggacg ggacaacatg gcccggttcg     1620

gcatcaagat catcatggct aatctggagg aaaaaagaat ccccatcacc aaggtgaagt     1680

tgaaagaggg atgtggtgcc gcaggaggcc ggtcctggaa ggccggcggc agcccaaaga     1740

agaagcggaa ggtctctaga caagagatca agagaatcaa caagatcaga aggagactgg     1800

tcaaggacag caacacaaag aaggccggca agacaggccc catgaaaacc ctgctcgtca     1860

gagtgatgac ccctgacctg agagagcggc tggaaaacct gagaaagaag cccgagaaca     1920

tccctcagcc tatcagcaac accagcaggg ccaacctgaa caagctgctg accgactaca     1980

ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg     2040

gcctgatgag cagagttgct cagcctgcca gcaagaagat cgaccagaac aagctgaagc     2100

ccgagatgga cgagaagggc aatctgacca cagccggctt tgcctgctct cagtgtggcc     2160

agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa aggcaaggcc tacaccaact     2220

acttcggcag atgtaacgtg gccgagcacg agaagctgat tctgctggcc cagctgaaac     2280

ctgagaagga ctctgatgag gccgtgacct acagcctggg caagtttgga cagagagccc     2340

tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag cccctggctc     2400

agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc gatgcctgca     2460

tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag caccagaagg     2520

tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc aaagagaacc     2580

tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc gtggacgcct     2640

acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg cagaagctga     2700

aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct agcttccctc     2760

tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc     2820

tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc ggctacaaga     2880

gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag ggcaagaagt     2940

tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac ggcgaggact     3000

ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca     3060

agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa gccgctctga     3120

ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag gccgacaagg     3180

acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg agaggcaagc     3240

ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc aagcagtaca     3300

actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac ctgatcatca     3360

attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc ttcgaggcta     3420

acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact     3480

tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag agacagggca     3540

gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg     3600

gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag cctgctctgt     3660

ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc aagcccatga     3720

acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg acagaccctg     3780

aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac atcctgagaa     3840

tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag gtggaacaga     3900

gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg gccgacgaca     3960

tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac gccatgctga     4020

tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt atggccgaga     4080

ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag ggactgagca     4140

agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc aattgcggct     4200

tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa accgccaccg     4260

gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc acctactaca     4320

acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac agactgagcg     4380

aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc gaggctctga     4440

gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg tgcctgaact     4500

gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga agctggctgt     4560

tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc aacaccgaca     4620

agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa gaagtctgga     4680

agcccgccgt gactagtcca aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg     4740

tccctgacta cgcttga                                                    4757


<210>  960
<211>  4821
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP51 plasmid sequence

<400>  960
atgggcgatc ctctgacatg gagcaaggcc ctgaagaagc tggagaaggt gaccgtgcag       60

ggcagccaga agctgaccac aggcaactgc aattgggccc tgtccctggt ggacctgttc      120

cacgatacaa actttgtgaa ggagaaggat tggcagctgc gcgacgtgat cccactgctg      180

gaggacgtga cccagacact gtctggccag gagcgggagg ccttcgagag aacctggtgg      240

gccatcagcg ccgtgaagat gggcctgcag atcaacaatg tggtggatgg caaggcctct      300

tttcagctgc tgagggccaa gtacgagaag aagacagcca acaagaagca gtctgagcct      360

agcgaggagt atccaatcat gatcgacggc gccggcaacc ggaatttcag accactgacc      420

cccagaggct acaccacatg ggtgaacaca atccagacca acggcctgct gaatgaggcc      480

tcccagaatc tgttcggcat cctgagcgtg gattgtacct ccgaggagat gaatgccttt      540

ctggacgtgg tgccaggaca ggcaggacag aagcagatcc tgctggacgc catcgataag      600

atcgccgacg attgggataa ccggcaccca ctgcccaatg cacctctggt ggcaccacct      660

cagggaccta tcccaatgac agccaggttt atcaggggac tgggagtgcc acgggagaga      720

cagatggagc ccgccttcga ccagtttagg cagacctacc gccagtggat catcgaggcc      780

atgagcgagg gcatcaaagt gatgatcggc aagccaaagg cacagaacat caggcaggga      840

gccaaggagc cctatcctga gttcgtggat agactgctgt cccagatcaa gtctgagggc      900

caccctcagg agatctccaa gtttctgacc gacacactga ccatccagaa cgccaatgag      960

gagtgccgga atgccatgcg gcacctgaga ccagaggata ccctggagga gaagatgtac     1020

gcctgtagag acatcggcac cacaaagcag aagatgatgc tgctggccaa ggccctgcag     1080

acaggcctgg ccggaccatt caagggaggc gccctgaagg gcggccccct gaaggccgcc     1140

cagacctgct ataactgtgg caagccagga cacctgagct cccagtgcag ggcaccaaag     1200

gtgtgcttca agtgtaagca gcctggccac ttttctaagc aatgcagaag tgttccaaaa     1260

aacgggaagc aaggggctca agggaggccc cagaaacaaa ctttcccgat acaacagaag     1320

agtcagcaca acaaatctgt tgtacaagag actcctcaga ctcaaaatct gtacccagat     1380

ctgagcgaaa taaaaaagga atacaatgtc aaggagaagg atcaagtaga ggatctcaac     1440

ctggacagtt tgtgggagta aacatataac ctggagaagc gccccaccac aatcgtgctg     1500

atcaacgaca cccctctgaa cgtgctgctg gacacaggag ctgatacatc tgtgctcacc     1560

accgcccact acaaccggct gaagtacaga ggcagaaagt accagggcac cggcatcatc     1620

ggcgtgggcg gaaatgtgga aaccttcagc accccagtga ccattaagaa aaagggccgg     1680

cacatcaaaa ccagaatgct ggtcgccgac atccctgtga caatcctggg cagagatatc     1740

cttcaggact taggtgcagg tgccagcgag gagtatccaa tcatgatcgg cggcagccca     1800

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1860

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1920

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1980

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     2040

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     2100

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     2160

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     2220

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     2280

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     2340

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     2400

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     2460

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2520

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2580

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2640

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2700

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2760

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2820

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2880

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2940

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     3000

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     3060

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     3120

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     3180

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     3240

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     3300

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     3360

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     3420

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3480

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3540

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3600

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3660

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3720

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3780

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3840

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3900

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3960

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     4020

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     4080

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     4140

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     4200

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     4260

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     4320

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     4380

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     4440

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4500

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4560

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4620

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4680

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4740

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4800

gatgtccctg actacgcttg a                                               4821


<210>  961
<211>  4871
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP52 plasmid sequence

<400>  961
atgggcgcca ggaacagcgt gctgtccggc aaggaggccg atgagctgga gaaggtgcgg       60

ctgagaccca atggcaagaa gaagtacatg ctgaagcacg tggtgtgggc agcaaacgag      120

ctggaccgct tcggcctggc cgagtctctg ctggataata aggagggctg ccagaagatc      180

ctgagcgtgc tggcccctct ggtgccaacc ggctctgaga acctgaagag cctgtataat      240

acagtgtgcg tgatctggtg tatccacgcc gaggagaagg tgaagcacac cgaggaggcc      300

aagcagatcg tgcagaggca cctggtggtg gagaccggca cagcagatag gatgccagcc      360

accagccgcc caacagcacc accttccgga aggggcggca actaccccgt gcagcaagtg      420

ggcggcaatt atgtgcacct gcccctgagc cctagaaccc tgaacgcctg ggtgaagctg      480

gtggaggaga agaagttcgg agcagaggtg gtgccaggat ttcaggccct gtccgagggc      540

tgcacaccct acgacatcaa ccagatgctg aattgcgtgg gagagcacca ggcagcaatg      600

cagatcatcc gggagatcat caacgaggag gcagcagact gggatctgca gcaccctcag      660

ccaggaccac tgcctgcagg acagctgcgg gagcctagag gctctgacat cgccggcacc      720

acaagcaccg tggatgagca gatccagtgg atgtacaggc agcagaaccc aatccccgtg      780

ggcaatatct atcggagatg gatccagctg ggcctgcaga agtgcgtgcg gatgtataac      840

ccaaccaata tcctggacgt gaagcagggc ccaaaggagc ccttccagag ctacgtggac      900

agattctaca agtccctgag agccgagcag acagatcccg ccgtgaagaa ctggatgacc      960

cagacactgc tgatccagaa cgccaatccc gattgcaagc tggtgctgaa gggcctgggc     1020

atgaatccta ccctggagga gatgctgaca gcatgtcagg gagtgggagg acctggacag     1080

aaggcaaggc tgatggcaga ggccctgaag gaggccctga ggcctgacca gctgccattt     1140

gccgccgtgc agcagaaggg ccagaggaag accatcaagt gctggaactg tggcaaggag     1200

ggacactctg ccaagcagtg cagggcacca aggcgccagg gatgctggaa gtgtggcaag     1260

acaggccacg tgatggccaa gtgtcctgag aggcaggcag gcttcctggg actgggacca     1320

tggggcaaga agccaagaaa ttttcctatg gcccagatgc ctcagggact gatcccaacc     1380

gcaccaccag aggacccagc agtggatctg ctgaagaact acatgaagat gggcaggaag     1440

cagcgcgaga atagggagcg cccttataag gaggtgacag aggacctgct gcacctgaac     1500

tctctctttg gagaagacca gtagttacag cctacatcga ggaacagcct gtggaagtgc     1560

tgctggatac aggagctgat gacagcatcg tggccggcat tgagctggga cctaactaca     1620

ccccaaagat cgtgggcggc atcggcggat tcatcaatac caaagagtac aaggacgtga     1680

agatcaaagt gctgggcaag gtgatcaagg gcaccatcat gaccggcgac acacccatca     1740

acatcttcgg cagaaacctg ctcaccgcca tgggcatgtc tctgaacctg cctatcgcca     1800

aggtcgaggg tgccggcggc aactaccccg tgcagcaagg cggcagccca aagaagaagc     1860

ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg     1920

acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga     1980

tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc     2040

agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga     2100

tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga     2160

tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga     2220

tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc     2280

tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg     2340

gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga     2400

aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact     2460

tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg     2520

ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa     2580

caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca     2640

agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat     2700

accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg     2760

aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt     2820

ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg     2880

aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca     2940

acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag     3000

aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca     3060

gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca     3120

aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca     3180

ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt     3240

ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt     3300

tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg     3360

ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg     3420

ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact     3480

tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat     3540

tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact     3600

tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt     3660

tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag     3720

tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg     3780

ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga     3840

tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat     3900

gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg     3960

agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag     4020

ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc     4080

gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg     4140

agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt     4200

acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct     4260

acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca     4320

tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga     4380

tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt     4440

acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga     4500

gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc     4560

tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct     4620

tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga     4680

gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg     4740

cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg     4800

ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg     4860

actacgcttg a                                                          4871


<210>  962
<211>  4700
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP53 plasmid Sequence

<400>  962
atggccaagc agggctccaa ggagaagaag ggctaccccg agctgaagga agtgatcaag       60

gcaacctgca agatcagggt gggacctggc aaggagaccc tgacagaggg caactgtctg      120

tgggccctga agacaatcga cttcatcttt gaggatctga agaccgagcc atggaccatc      180

acaaagatgt atacagtgtg ggatcggctg aagggactga ccccagagga gacatccaag      240

agagagttcg cctctctgca ggccaccctg gcctgcatca tgtgctccca gatgggcatg      300

aagcctgaga cagtgcaggc cgccaagggc atcatctcta tgaaggaggg cctgcacgag      360

aataaggagg ccaagggcga gaaggtggag cagctgtacc ctaacctgga gaagcacagg      420

gaggtgtatc caatcgtgaa tctgcaggca ggaggccgca gctggaaggc agtggagtcc      480

gtggtgttcc agcagctgca gaccgtggcc atgcagcacg gcctggtgtc tgaggacttt      540

gagcggcagc tggcctacta tgccaccaca tggacaagca aggatatcct ggaggtgctg      600

gccatgatgc caggcaacag agcccagaag gagctgatcc agggcaagct gaatgaggag      660

gcagagcggt gggtgagaca gaacccacct ggacccaatg tgctgaccgt ggaccagatc      720

atgggcgtgg gccagacaaa ccagcaggcc agccaggcca atatggatca ggccaggcag      780

atctgcctgc agtgggtcat caccgccctg aggagcgtgc gccacatgtc ccacaggcct      840

ggaaacccaa tgctggtgaa gcagaagaat acagagtcct acgaggactt catcgccagg      900

ctgctggagg caatcgacgc agagcccgtg acagatccta tcaagaccta cctgaaggtg      960

accctgtctt atacaaacgc cagcaccgac tgccagaagc agatggatag gaccctggga     1020

acacgcgtgc agcaggcaac cgtggaggag aagatgcagg cctgtcggga tgtgggctct     1080

gagggcttta agatgcagct gctggcccag gccctgagac ctcagggcaa ggcaggacag     1140

aagggagtga accagaagtg ctacaattgt ggcaagccag gacacctggc aaggcagtgc     1200

agacagggaa tcatctgcca ccactgtggc aagaggggcc acatgcagaa ggactgtcgc     1260

cagaagaagc agcagggcaa caataggaga ggaccaaggg tggtgccatc tgccccacca     1320

atgctgtgac agaggcccct cctaagatcg agatcaaggt gggcacaaga tggaagaaac     1380

tgctggtcga caccggcgct gataagacca tcgtgaccag ccacgacatg agcggcatcc     1440

ccaagggcag aatcatcctg cagggcattg gaggaatcat cgagggcgag aagtgggagc     1500

aggtgcacct gcagtacaag gacaagatca tccggggcac catcgtggtg ctcgccacat     1560

ctccagtgga agtgctggga agagataaca tgcgggaact gggcatcggc ctgatcatgg     1620

ctaacctgga agagaaaggt gccagggagg tgtatccaat cgtgaatggc ggcagcccaa     1680

agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc agaaggagac     1740

tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa accctgctcg     1800

tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag aagcccgaga     1860

acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg ctgaccgact     1920

acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag aaagaccccg     1980

tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag aacaagctga     2040

agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg     2100

gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag gcctacacca     2160

actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg gcccagctga     2220

aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt ggacagagag     2280

ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg aagcccctgg     2340

ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg tccgatgcct     2400

gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc gagcaccaga     2460

aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc ggcaaagaga     2520

acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa ggcgtggacg     2580

cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc     2640

tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc cctagcttcc     2700

ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc aacgtgaaga     2760

agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg gccggctaca     2820

agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag aagggcaaga     2880

agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg     2940

actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg gaaggcctga     3000

gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct aaagccgctc     3060

tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa gaggccgaca     3120

aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat ctgagaggca     3180

agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc agcaagcagt     3240

acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg tacctgatca     3300

tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag gccttcgagg     3360

ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc atggaagtga     3420

acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc aagagacagg     3480

gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg aagctggcca     3540

atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac gagcctgctc     3600

tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac atcaagccca     3660

tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc ctgacagacc     3720

ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca cacatcctga     3780

gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa gaggtggaac     3840

agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat ctggccgacg     3900

acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag gacgccatgc     3960

tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc tttatggccg     4020

agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac gagggactga     4080

gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc agcaattgcg     4140

gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag aaaaccgcca     4200

ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag atcacctact     4260

acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg gacagactga     4320

gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca ggcgaggctc     4380

tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc gtgtgcctga     4440

actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc agaagctggc     4500

tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc ggcaacaccg     4560

acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg aaagaagtct     4620

ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt agccctcgag tacccatatg     4680

atgtccctga ctacgcttga                                                 4700


<210>  963
<211>  5479
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP54 plasmid sequence

<400>  963
agccattgcc ttttatggta atcgtgcgag agggcgcagg gacttccttt gtcccaaatc       60

tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct ctagcgggcg cggggcgaag      120

cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc      180

cgtccccttc tccctctcca gcctcggggc tgtccgcggg gggacggctg ccttcggggg      240

ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag agcctctgct      300

aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttattgtg      360

ctgtctcatc attttggcaa agaattcgcc accatggccc tgaatgattt cgaccctatc      420

gccctccagg gctacctgcc ggcccctaga gtgctgcaac acaacgacat catcatctgc      480

agagctactt ctggcccctg gggcatcggc gacagataca acctgatcag gatccacctg      540

caagaccctg ccggacagcc ccttccaatc ccccagtggg agcctatccc taaccggacc      600

gccaaccccc ggacacagcc ctaccctgtg gtgtctgccc caatggctac cctggaaaac      660

atcctgaaca actttcacat cccccacggc gtgtccagat acggccccct ggaaggcgga      720

gattaccagc ctggcgaaca gtacagccaa ggcttctgcc ctgtgaccca ggccgagatt      780

gccctgctga acggccagca cctggaagaa gagatcacaa tcctgagaga gatcacccac      840

agactgatgc agggcgtgcg gcctcctgcc gtgcctcagg gccctgctcc tcctcctcct      900

ccagctcagc ctcctgctcc cctgcctgct ccaccaattg ggcctccacc tcccgctgcc      960

cctgcccccg ccccaggccc catgcctgtg ccccagcatc tgcctattac acatatcaga     1020

gccgtgatcg gcgaaacccc cgccaacatc cgcgaggtgc cactgtggct ggctagagcc     1080

gttcccgccc tgcagggagt gtaccccgtc caggacgccg tgatgagaag ccgcaccgtg     1140

aacgccctga ccgtgcggca ccctggactg gccctggaac ctctggagtg cggcagctgg     1200

caagagtgtc tggccgccct gtggcagaga accttcggcg ccaccgccct gcacgccctg     1260

ggcgataccc tgggtcagat cgcaaacagc gacggcatcg tgatggctat cgagctgggc     1320

ctgctctttt ccgatgataa ctgggacctg gtgtggggaa tctgtagaag attcctgccc     1380

ggccaggccg tctgcgtggc cgtgcaggcc agactggatc ccctgcccga caacgctaca     1440

agaatcgtga tgatcagcca catcatccgg gacgtgtacg ccatcctggg cctggaccct     1500

ctgggcagac ccatgcagca gacactgcct agacggaaca accagcctcc cagacagcag     1560

ccacagagac ggcagcagcc tagaagaacc ggcaaccagg aggaaagagg ccagcggaac     1620

cggggccggc agaacgccca gacccctcgg caggagggca acagactgca gaacagccag     1680

ctgcctggcc ctcgcgactg ccccaacaat agcaaccagc ctcggtaccc tctgcggcca     1740

aacccccagc agccccaaag atacggccag gagcagaatc gtggcaacaa tcccaaccct     1800

tacagacaac ctacccctgg caatggaaat caaaacagaa acttcagccg ggggcctgcc     1860

ccagtcaatg agcagagcag aggcagagga agatctagcc agggtacaaa taacaccggc     1920

tcctctgctg tgcacagcgt gcggctgacc agcgccgccc ctcctatacc cccacaagat     1980

gccggcactc cgcccacttc aagtggaaat caagggcaat catcttaaag gctactggga     2040

cagcggcgcc gagatcacat gcgtgcccgc tatctacatc atcgaggaac aacctgttgg     2100

caagaagctg attacaacca tccacaacga gaaggaacat gatgtgtact acgtggaaat     2160

gaaaatcgag aagcggaagg tgcagtgtga agtgatcgcc accgccctgg attacgtgct     2220

ggtggcccct gtggacatcc cctggtataa gcctggacct ctggaactga ccatcaagat     2280

cgacgtcgag agccagaagc acaccctgat cacagagtcc accctctctc cacagggcca     2340

gatgagactg aagaaactgc tggaccagta ccaggccctg tggcagtgct gggagaacca     2400

ggtgggccac agaagaggtg cctctgctgt gcacagcgtg cggctgggcg gcagcccaaa     2460

gaagaagcgg aaggtctcta gacaagagat caagagaatc aacaagatca gaaggagact     2520

ggtcaaggac agcaacacaa agaaggccgg caagacaggc cccatgaaaa ccctgctcgt     2580

cagagtgatg acccctgacc tgagagagcg gctggaaaac ctgagaaaga agcccgagaa     2640

catccctcag cctatcagca acaccagcag ggccaacctg aacaagctgc tgaccgacta     2700

caccgagatg aagaaagcca tcctgcacgt gtactgggaa gagttccaga aagaccccgt     2760

gggcctgatg agcagagttg ctcagcctgc cagcaagaag atcgaccaga acaagctgaa     2820

gcccgagatg gacgagaagg gcaatctgac cacagccggc tttgcctgct ctcagtgtgg     2880

ccagcctctg ttcgtgtaca agctggaaca ggtgtccgag aaaggcaagg cctacaccaa     2940

ctacttcggc agatgtaacg tggccgagca cgagaagctg attctgctgg cccagctgaa     3000

acctgagaag gactctgatg aggccgtgac ctacagcctg ggcaagtttg gacagagagc     3060

cctggacttc tacagcatcc acgtgaccaa agaaagcaca caccccgtga agcccctggc     3120

tcagatcgcc ggcaatagat acgcctctgg acctgtgggc aaagccctgt ccgatgcctg     3180

catgggaaca atcgccagct tcctgagcaa gtaccaggac atcatcatcg agcaccagaa     3240

ggtggtcaag ggcaaccaga agagactgga aagcctgagg gagctggccg gcaaagagaa     3300

cctggaatac cccagcgtga ccctgcctcc tcagcctcac acaaaagaag gcgtggacgc     3360

ctacaacgaa gtgatcgcca gagtgagaat gtgggtcaac ctgaacctgt ggcagaagct     3420

gaaactgtcc agggacgacg ccaagcctct gctgagactg aagggcttcc ctagcttccc     3480

tctggtggaa agacaggcca atgaagtgga ttggtgggac atggtctgca acgtgaagaa     3540

gctgatcaac gagaagaaag aggatggcaa ggttttctgg cagaacctgg ccggctacaa     3600

gagacaagaa gccctgaggc cttacctgag cagcgaagag gaccggaaga agggcaagaa     3660

gttcgccaga taccagctgg gcgacctgct gctgcacctg gaaaagaagc acggcgagga     3720

ctggggcaaa gtgtacgatg aggcctggga gagaatcgac aagaaggtgg aaggcctgag     3780

caagcacatt aagctggaag aggaaagaag gagcgaggac gcccaatcta aagccgctct     3840

gaccgattgg ctgagagcca aggccagctt tgtgatcgag ggcctgaaag aggccgacaa     3900

ggacgagttc tgcagatgcg agctgaagct gcagaagtgg tacggcgatc tgagaggcaa     3960

gcccttcgcc attgaggccg agaacagcat cctggacatc agcggcttca gcaagcagta     4020

caactgcgcc ttcatttggc agaaagacgg cgtcaagaaa ctgaacctgt acctgatcat     4080

caattacttc aaaggcggca agctgcggtt caagaagatc aaacccgagg ccttcgaggc     4140

taacagattc tacaccgtga tcaacaaaaa gtccggcgag atcgtgccca tggaagtgaa     4200

cttcaacttc gacgacccca acctgattat cctgcctctg gccttcggca agagacaggg     4260

cagagagttc atctggaacg atctgctgag cctggaaacc ggctctctga agctggccaa     4320

tggcagagtg atcgagaaaa ccctgtacaa caggagaacc agacaggacg agcctgctct     4380

gtttgtggcc ctgaccttcg agagaagaga ggtgctggac agcagcaaca tcaagcccat     4440

gaacctgatc ggcgtggacc ggggcgagaa tatccctgct gtgatcgccc tgacagaccc     4500

tgaaggatgc ccactgagca gattcaagga ctccctgggc aaccctacac acatcctgag     4560

aatcggcgag agctacaaag agaagcagag gacaatccag gccaagaaag aggtggaaca     4620

gagaagagcc ggcggatact ctaggaagta cgccagcaag gccaagaatc tggccgacga     4680

catggtccga aacaccgcca gagatctgct gtactacgcc gtgacacagg acgccatgct     4740

gatcttcgag aatctgagca gaggcttcgg ccggcagggc aagagaacct ttatggccga     4800

gaggcagtac accagaatgg aagattggct cacagctaaa ctggcctacg agggactgag     4860

caagacctac ctgtccaaaa cactggccca gtatacctcc aagacctgca gcaattgcgg     4920

cttcaccatc accagcgccg actacgacag agtgctggaa aagctcaaga aaaccgccac     4980

cggctggatg accaccatca acggcaaaga gctgaaggtt gagggccaga tcacctacta     5040

caacaggtac aagaggcaga acgtcgtgaa ggatctgagc gtggaactgg acagactgag     5100

cgaagagagc gtgaacaacg acatcagcag ctggacaaag ggcagatcag gcgaggctct     5160

gagcctgctg aagaagaggt ttagccacag acctgtgcaa gagaagttcg tgtgcctgaa     5220

ctgcggcttc gagacacacg ccgatgaaca ggctgccctg aacattgcca gaagctggct     5280

gttcctgaga agccaagagt acaagaagta ccagaccaac aagaccaccg gcaacaccga     5340

caagagggcc tttgtggaaa cctggcagag cttctacaga aaaaagctga aagaagtctg     5400

gaagcccgcc gtgactagtc caaaaaagaa gagaaaggta gccctcgagt acccatatga     5460

tgtccctgac tacgcttga                                                  5479


<210>  964
<211>  5764
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP55 plasmid sequence

<400>  964
agccattgcc ttttatggta atcgtgcgag agggcgcagg gacttccttt gtcccaaatc       60

tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct ctagcgggcg cggggcgaag      120

cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc ttcgtgcgtc gccgcgccgc      180

cgtccccttc tccctctcca gcctcggggc tgtccgcggg gggacggctg ccttcggggg      240

ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag agcctctgct      300

aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttattgtg      360

ctgtctcatc attttggcaa agaattcgcc accatgagcc agccctccgc ttctggcagc      420

gccggcgccg gaggcgcccc tcagcaacct cctcctccac ctccccagcc cggacctgcc      480

gcccccgtgc ctagagccca gatcggttat ggagatctgg acgtgcttct gctgcaacag      540

gagtaccacc tcatcgatcc taatctgcaa gtgcaacacc tggacaccct gctggtgaga      600

atcacaggcg gaaactgggg ccctggcgat agattcgcca gaatcgaggt gctgctccgc      660

gacacactgg gccctctgca acagcctaga tacagatacg ccgccatgca gcaggccgac      720

ctgagaaacg acatcatcct gcacctgaac taccaggatg ccatcatcat cttcgacatg      780

atcatcccca gcgagggcgt gcaccggcac ggccctatgt ttgacggcct gtggatccac      840

ggcgacgact acagcatgaa cttccagcct atcacagccc acgagctgta cctgctgcct      900

cagcaggtgc tgaccgagga agtggaactg ctcaccgagg tgtgcaacag aatggccgat      960

tggatccggc ggcacaggtg tggcggagga agcggctcct ctcagccacc tcctccccca     1020

cctccagccg tgccagtgct gcctagtgcc cctccagcca gcagcctgcc cctgccccca     1080

cagggctggg gcatctctcc tcccgtggct accagcaccc ctggcgctgc cggacattct     1140

agcagcgccg gtcctaacat cagcctgggc ggcacctacg tgccccctcc tgtggctcct     1200

ccagcccctg tgatcggcgg ccctggcgga cccggacagc tgcctgctat ggtgcaggtg     1260

ctgcccgctc aacctgtcgt gatccccatt aacgtgatca gatctgtgtg cggcgataca     1320

cctagcaacc ctcaagacat ccctctgtgg atgggcagaa tcatccccgc cattgagggc     1380

gtctttccta ttgacaaccc caatctgaga atgagagtgg tgaacgccct gctggctctg     1440

catcctggcc tggctatcac cgaactgaat gcccagacat ggggccaggt tctggctgtg     1500

ctgcacatgc gggccctggg acacaccgcc ctgcaccagc tgcctgccct gctggaaaca     1560

atcgtgaaga ccgacggcat cctgccagct tataacatgg gcatggaagt tacacagcag     1620

gatttcagct acgtgtgggg catcctgcgg acactgttgc ccggccaagc cttcgtgctg     1680

agcatgcaga acgagctgga ccggctgcct gccgcccaga gacctggaat gttccccggc     1740

ctgctgcaga gaaccctgga tatcctgggc ctgaacagca gaggacagaa catccagaaa     1800

accaacaccc agcagcaggc cccaaagcgg ggccagaagc ctaagcccag actgccccca     1860

gtgcacagac ggcctgcacc cttcacccct cctgccaccc ccagccctcg gcagcaggcc     1920

agcgccagcc ccagcagcca gggcgacaac agaagccctc agcctcaggg cagaggcaca     1980

tacggcccga gccggggagg cggctctggc cctagataca acttccgtcc cagagtgcag     2040

cctcccgaca gatacggctt cggcagaggc cagggaggca gaagcagcat cggcgcccag     2100

gacaatcagc agcccggaca aggcggacag cggacccagc agaccaacca gaaccgcaac     2160

cagggcaacg ccaccggcgg tagaacccag cctcagaata gaacagtgaa caccgtgcgg     2220

gtgacccaga ccaatcctca aggcggctcc tccgtgtcca acccagctgt gacaacttct     2280

cagaatacag gaacaggaag tgcaactcag agctcatcat cttaaaggct ttgtggacac     2340

aggcagcagc atcacctgct tccccaagta caccctggtc gaggaagatc ctatcggcca     2400

gtacgacatc agcaccatcc acggcacagt gtcccagcct gtgtactaca tcaagttcaa     2460

ggtgaacggc aagaaagtgg aagccgaggt gaccgagtct ccactggact acgtgatcct     2520

gtgtcctagc gacgtgccct ggctgtctac aaagctggaa ctgacaatta agctgcctct     2580

gcaccagcag caacaggagc tgctgagcaa gaccagagtg aatcaaaaac agctgcagaa     2640

actctttatc cagtatgatg acctgtggca gaagtgggag aaccaggttg gacaccggaa     2700

gggtgccaga acagtgaaca ccgtgcgggt gggcggcagc ccaaagaaga agcggaaggt     2760

ctctagacaa gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa     2820

cacaaagaag gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc     2880

tgacctgaga gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat     2940

cagcaacacc agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa     3000

agccatcctg cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag     3060

agttgctcag cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga     3120

gaagggcaat ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt     3180

gtacaagctg gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg     3240

taacgtggcc gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc     3300

tgatgaggcc gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag     3360

catccacgtg accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa     3420

tagatacgcc tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc     3480

cagcttcctg agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa     3540

ccagaagaga ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag     3600

cgtgaccctg cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat     3660

cgccagagtg agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga     3720

cgacgccaag cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca     3780

ggccaatgaa gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa     3840

gaaagaggat ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct     3900

gaggccttac ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca     3960

gctgggcgac ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta     4020

cgatgaggcc tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct     4080

ggaagaggaa agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag     4140

agccaaggcc agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag     4200

atgcgagctg aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga     4260

ggccgagaac agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat     4320

ttggcagaaa gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg     4380

cggcaagctg cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac     4440

cgtgatcaac aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga     4500

ccccaacctg attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg     4560

gaacgatctg ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga     4620

gaaaaccctg tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac     4680

cttcgagaga agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt     4740

ggaccggggc gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact     4800

gagcagattc aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta     4860

caaagagaag cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg     4920

atactctagg aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac     4980

cgccagagat ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct     5040

gagcagaggc ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag     5100

aatggaagat tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc     5160

caaaacactg gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag     5220

cgccgactac gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac     5280

catcaacggc aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag     5340

gcagaacgtc gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa     5400

caacgacatc agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa     5460

gaggtttagc cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac     5520

acacgccgat gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca     5580

agagtacaag aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt     5640

ggaaacctgg cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac     5700

tagtccaaaa aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc     5760

ttga                                                                  5764


<210>  965
<211>  5404
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP56 plasmid Sequence

<400>  965
atggcctctg gcagcaacgt ggaggaatac gagctggatg tggaagccct ggtggtcatc       60

ctgcgggaca gaaacatcgg aagaaatccc ctgcacggcg aaatcatcgg cctgagactg      120

accgagggct ggtggggcca gatcgagaga tttcagatgg tgcggctgat cctgcaggac      180

gacgacaacg agcccctgca gagaccccgc tacgaggtga tccccagagc cgtgaacccc      240

cacaccatgt tcatgatcag cggccccctg gctgaactgc agctggcctt ccaggacctg      300

gacctgcccg agggccctct gcggtttggc ccgctggcta acggccacta cgtgcagggg      360

gatccttaca gcagcagcta ccggcccgtg accatggccg aaacagccca gatgaccaga      420

gatgagctgg aagatatcct gaacacccaa agcgagatcg agatccagat gatcaacctg      480

ctggaacttt atgaggtgga aaccagagcc ctgagaagac agctggccga gagaagcagc      540

atcggccagg gaggagtgag ccccggcgct ccaaggccga gacctccagt tagcagcttc      600

agcggcctgc ctagcctgcc ttctatcccc ggcatccacc ccagagcccc ttcccctcct      660

cgcgctacaa gcacccctgg taacatcccc tggtccctgg gagatgacag cccacctagc      720

tcgtcttttc ctggccctag tcagcctaga gtgtctttcc accctggcaa tcctttcgtg      780

gaggacgagg gacatagacc tagatcccag agccgggaaa gacggagaaa caatcctcct      840

gcccctatcc ctagcgcccc tccaatgatc caatacgtgc ccgtgcctcc tccacctcct      900

gtcggaaccg tgatacctat ccaacacatc cggtccgtga ccggcgagcc tccaaagaac      960

ccccgagaaa tccccatctg gctgggccgg aatgcccctg ctatcgacgg cgttttcccc     1020

gtgacgaccc cagacctgcg gtgcagaatc atcaacgcca ttctgggagg caacctgggc     1080

ctgagcctga cacctgccga ctgtgtgacc tgggactctg ccgtgggcac cctgttcgtg     1140

cggacacacg gacagttccc tatgcaccag ctgggcacag tgatccaggg catcgtgaac     1200

caggagggcg tggctaccgc ttatacactg ggcatgatgc tgagcggcca gaattacccc     1260

ctcgtgagcg gcatcatcag aggctacctg cccggccagg ccgtggtgac cgcccttcag     1320

cagcgcctgg accaggaggt ggatgaccag gccagggctg aaaccttcat ccagcacctg     1380

aacgctgtgt acgagatcct gggcctcaac gccagaggac aatctatcag agccagcgtg     1440

acaccgcaac ctcggccaag ccggggccgc ggcagaggcc agtctacacc tagaccttcc     1500

cagggccctg tgagttcagg acggggcaga cagcggcctg ccagcggcca gtacgacaga     1560

ggcagcaaca accagaacca agaccagggt aacaccagcc agggcggcta caacctgaga     1620

ccaagaacct accagcctca gagatacggc ggcggaagag gtcggagatg gaacgagaac     1680

accaacagcc aggagagcag acccagcgat cagggctccc agacaccccg gcctaaccaa     1740

gctggcagcg gcgtcagagg caaccagagc cagaccccta gacccgccgc cggcagagga     1800

ggcagaggca atcagaatag aaaccagcgg tctagcggag ccggcgatag cagagccgtc     1860

aacacagtga cccagagtgc cacgtcctcc acagatgaat cctcttcagc tgttgcaacc     1920

gcttccagcg gagatcaaag gaactaaact gttagcccat tgggacagcg gcgccaccat     1980

tacatgcgtg cccgagtcct tcctggaaga tgagcagcct atcaaacaga ccctgatcaa     2040

gacaatccac ggcgagaagc agcagaaagt gtactacctg acctttaaga tcaagggaag     2100

aaaggtggaa gctgaagtga tcgccagccc ttacgagtac atcctgctgt ctccaacaga     2160

cgtgccttgg ctgacacagc aacctctgca gctgaccatc ctggtccccc tgcaggagta     2220

tcaggataga atcctcaaca agaccgccct gcctgaggaa cagaagcaaa gactgaagac     2280

cctgttcgcc aagtacgaca ccctgtggca gcactgggag aaccaggtgg gccaccggcg     2340

gggtgccaga gccgtcaaca cagtgaccca gggcggcagc ccaaagaaga agcggaaggt     2400

ctctagacaa gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa     2460

cacaaagaag gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc     2520

tgacctgaga gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat     2580

cagcaacacc agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa     2640

agccatcctg cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag     2700

agttgctcag cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga     2760

gaagggcaat ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt     2820

gtacaagctg gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg     2880

taacgtggcc gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc     2940

tgatgaggcc gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag     3000

catccacgtg accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa     3060

tagatacgcc tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc     3120

cagcttcctg agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa     3180

ccagaagaga ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag     3240

cgtgaccctg cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat     3300

cgccagagtg agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga     3360

cgacgccaag cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca     3420

ggccaatgaa gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa     3480

gaaagaggat ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct     3540

gaggccttac ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca     3600

gctgggcgac ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta     3660

cgatgaggcc tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct     3720

ggaagaggaa agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag     3780

agccaaggcc agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag     3840

atgcgagctg aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga     3900

ggccgagaac agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat     3960

ttggcagaaa gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg     4020

cggcaagctg cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac     4080

cgtgatcaac aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga     4140

ccccaacctg attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg     4200

gaacgatctg ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga     4260

gaaaaccctg tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac     4320

cttcgagaga agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt     4380

ggaccggggc gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact     4440

gagcagattc aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta     4500

caaagagaag cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg     4560

atactctagg aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac     4620

cgccagagat ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct     4680

gagcagaggc ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag     4740

aatggaagat tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc     4800

caaaacactg gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag     4860

cgccgactac gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac     4920

catcaacggc aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag     4980

gcagaacgtc gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa     5040

caacgacatc agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa     5100

gaggtttagc cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac     5160

acacgccgat gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca     5220

agagtacaag aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt     5280

ggaaacctgg cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac     5340

tagtccaaaa aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc     5400

ttga                                                                  5404


<210>  966
<211>  5140
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP57 plasmid sequence

<400>  966
atggcccaga acgagacatt tgatcctgtg gccctgcagg gctactaccc tgctggcggc       60

atcctggccg acaatgacat tatcaacatc agattcacca gcggacagtg gggcatcggc      120

gatagatggc tgcaggtgcg gctgagactg gtggacccta atactggaca gcctctggct      180

cagcctgagt acgaggacac aggcctgcct gccgaaaaca ggggtatcgt ggtggccgtg      240

tcccacaacg ccgccagaaa tatcttcaac aacgtgcagc cagctggtgg ccccaacaga      300

cacggccctc tgcacgacgg ccaatttcaa gtgggcgacg atcccagcga gcacttcgtg      360

cctattgagg aaaacctgat cccccaggag atcgtgaacc tgggagcagc tagaagagaa      420

gtgcggctgc tgagagaaat gtgcgtgcgg ctgctgcacg tgagaagaca gatgatgggc      480

atgggcatgc ctggcgctat ccagcctcaa ccgccagtgg gccccctgcc cgcccctgcc      540

cagcccccta tccctggccc acctgtgcct ccccccgtgc ctccccccgc ccctccagcc      600

cctgtcaacc cccctgtccc tccagtgcag cctatccacc acctgcctat tacccacatc      660

cgggccgtga tcggcgagac acctgcccag atcagagatg tgcccctgtg gctggcccag      720

tccatccctg ccctgaccgg cgtttatcct gccatggacg ccggaacact gacaagactg      780

gtgaacgcga tcaccgccag acaccccgga ctcgctcttg gcatgaacga ggccggctcc      840

tggcacgagg ccgttcatct gatctggcag aggaccttcg gcgctacagc cctccatgcc      900

ttgtctgatg tgctgaaggg catcgcccag cggaacggcg tggtgatggc cctggaaatg      960

ggcctgatgt tcaccaacga cgactgggac ctgacctggt ctgtgatccg gagatgtctg     1020

cctggacaag ccagcgttgt gaccatccag gcccggctgg atgccctgcc aaacaaccag     1080

gccaggatca tccaggccgg ctttatcatc agagaggtgt acgaggtgct gggcctggac     1140

ccactgggcc ggccactgaa cttccctgga ggcctgaccc agcgagacac cgccgtgccc     1200

gtgaccagag gccggggccg cggaagaacc ggccctagaa gaggccctgt gctgcctgtc     1260

agcagcaacc agcgccggca agaaaccgca ggcggcaacc agcctcagac ccaaccccag     1320

cagcagaaca cattcagcaa tcagacaaat cagagaggaa accagcggca gtggcaaaat     1380

agaggaaccg acagccagag acggtacttc ttcagaccca gaccaagcca gcctcagcgg     1440

tacggcagca accagggccc tgacaaccct aatccctaca gaggaagaga tagcaccaat     1500

caaagcggcc aggagcggca gctgcctcag cagcaacagg gctctagaag gggccctggc     1560

agaaacacaa acagcggcaa caacaccgtg cacaccgtgc ggcaagtgga atcttctcag     1620

ctacaacaaa atgcaagccc tacagcctct ccaagtacaa atcaagggca acagccttaa     1680

gggattttat gataccggcg ccgagatcac ctgcgtgcca gccatcttcc tgatcgagga     1740

agagcctatc ggcgagcgga ccatccaaac aatccacggc atcacaaagg aaaaggtgta     1800

ctacctgacc tttaagatcc agggcagaaa gctggccgct gaagtgattg gaacccagct     1860

ggactacgtg atcatcgccc ctagcgacat cccctggtac aagaaatacg agctggaact     1920

gacaattaaa atcgacatcc agaaacagca ggagcagctg ctgcacacca ccaacctctc     1980

tagcgaggga aagaagtacc tgaaggacct gttcatcaag tatgataatc tgtggcagaa     2040

gtgggaaaac caggtcggcc acagaagagg tgccaacacc gtgcacaccg tgcggcaagt     2100

ggaatctggc ggcagcccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat     2160

caacaagatc agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg     2220

ccccatgaaa accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa     2280

cctgagaaag aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct     2340

gaacaagctg ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga     2400

agagttccag aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa     2460

gatcgaccag aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg     2520

ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga     2580

gaaaggcaag gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct     2640

gattctgctg gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct     2700

gggcaagttt ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac     2760

acaccccgtg aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg     2820

caaagccctg tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga     2880

catcatcatc gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag     2940

ggagctggcc ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca     3000

cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa     3060

cctgaacctg tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact     3120

gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga     3180

catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg     3240

gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga     3300

ggaccggaag aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct     3360

ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga     3420

caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga     3480

cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga     3540

gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg     3600

gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat     3660

cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa     3720

actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat     3780

caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga     3840

gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct     3900

ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac     3960

cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac     4020

cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga     4080

cagcagcaac atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc     4140

tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg     4200

caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca     4260

ggccaagaaa gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa     4320

ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc     4380

cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg     4440

caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa     4500

actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc     4560

caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga     4620

aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt     4680

tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag     4740

cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa     4800

gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca     4860

agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct     4920

gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa     4980

caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag     5040

aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt     5100

agccctcgag tacccatatg atgtccctga ctacgcttga                           5140


<210>  967
<211>  4996
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP58 plasmid sequence

<400>  967
atggcccggg aactgaaccc cctgcagctg caacagctgt acatcaacaa tggcctgcag       60

cccaatcccg gccacggaga tatcatcgca gttagattca caggcggccc ttggggcccc      120

ggagatagat gggccagagt gaccatccgg ctgcaggaca acaccggcca gcctctgcaa      180

gtgcccggat acgacctgga gcctggcatc atcaatctgc gggaagatat cctgatcgcc      240

ggcccataca acctcatcag aacagctttt ctggacctgg aacctgccag aggaccagag      300

cggcacggcc cgttcggcga cggcagactg cagcctggcg atggactgag cgagggattt      360

cagcctatca ccgacgagga aatccaggct gaagtgggca ccatcggcgc cgcccgtaac      420

gagatccggc tgctgagaga agccttgcag agactccagg ctggcggtgt tggacggcct      480

atccctgggg ccgtgctgca gcctcaacct gtgatcggac ctgtgatccc catcaaccac      540

ctgagaagcg tgattggcaa cacacctcct aaccccagag atgtggccct gtggttgggc      600

agatctacag ccgctatcga gggcgtgttc cccatcgtgg accaggtgac ccggatgaga      660

gtggtgaacg ccctggtcgc ctctcatcct ggcctgaccc tgacagagaa cgaggccggc      720

agctggaacg ccgccatcag cgccctgtgg cggaaggccc acggcgctgc tgctcagcac      780

gagctggccg gagtgctgag cgacatcaac aagaaggaag gcatccagac agccttcaac      840

ctgggcatgc agttcaccga tggcaattgg tccctggtgt ggggaatcat caggaccctg      900

ctgcccggcc aggccctggt cacaaacgcc cagagccagt tcgacctgat gggcgacgac      960

attcagcggg ccgagaactt ccccagagtg attaacaacc tgtacaccat gctgggcctg     1020

aacatccacg gccagagcat cagacctaga gtgcagaccc agcctctgca gaccagacct     1080

cggaaccctg gcagaagcca gcagggtcag ctgaatcagc ctcggcctca gaacagagcc     1140

aaccagtcct acagaccccc tcggcagcag caacaacaca gcgacgtgcc tgagcagagg     1200

gaccagagag gcccatctca accgcctaga ggctctggcg gaggctataa cttcagaaga     1260

aatccccagc agcctcagcg gtacggccaa ggcccccccg gcccaaaccc ttacagacgg     1320

ttcggcgacg gcggcaatcc ccagcagcaa ggcccgcctc caaatagagg ccctgatcag     1380

ggacctagac caggcggcaa ccctcgcggc ggcggcaggg ggcagggccc ccggaacggc     1440

ggaggcagcg ccgccgccgt gcacaccgtg aaagccagcg aaaacgaaac taaaaatgga     1500

tctgctgaag ccgttgacgg tggaaagaaa gggggtaaag attaaaggtt actgggattc     1560

tcaggccgac atcacctgcg tgccaaagga cctgctgcag ggcgaggaac ccgtgcggca     1620

gcagaatgtg accaccatcc acggcaccca ggagggcgat gtctactacg tgaacctgaa     1680

gatcgacggc agaagaatca acaccgaggt gatcggcaca acactggact atgctatcat     1740

cacccctggc gacgtgcctt ggatcctgaa gaaacctctg gaactgacaa ttaagctgga     1800

tctggaagag caacaaggaa ccctgctcaa caacagcatc ctgagcaaga agggcaagga     1860

agagctgaaa cagctgttcg agaagtactc cgccctgtgg cagagctggg agaaccaggt     1920

gggacacaga cggggtgccg ccgccgtgca caccgtgaaa gccggcggca gcccaaagaa     1980

gaagcggaag gtctctagac aagagatcaa gagaatcaac aagatcagaa ggagactggt     2040

caaggacagc aacacaaaga aggccggcaa gacaggcccc atgaaaaccc tgctcgtcag     2100

agtgatgacc cctgacctga gagagcggct ggaaaacctg agaaagaagc ccgagaacat     2160

ccctcagcct atcagcaaca ccagcagggc caacctgaac aagctgctga ccgactacac     2220

cgagatgaag aaagccatcc tgcacgtgta ctgggaagag ttccagaaag accccgtggg     2280

cctgatgagc agagttgctc agcctgccag caagaagatc gaccagaaca agctgaagcc     2340

cgagatggac gagaagggca atctgaccac agccggcttt gcctgctctc agtgtggcca     2400

gcctctgttc gtgtacaagc tggaacaggt gtccgagaaa ggcaaggcct acaccaacta     2460

cttcggcaga tgtaacgtgg ccgagcacga gaagctgatt ctgctggccc agctgaaacc     2520

tgagaaggac tctgatgagg ccgtgaccta cagcctgggc aagtttggac agagagccct     2580

ggacttctac agcatccacg tgaccaaaga aagcacacac cccgtgaagc ccctggctca     2640

gatcgccggc aatagatacg cctctggacc tgtgggcaaa gccctgtccg atgcctgcat     2700

gggaacaatc gccagcttcc tgagcaagta ccaggacatc atcatcgagc accagaaggt     2760

ggtcaagggc aaccagaaga gactggaaag cctgagggag ctggccggca aagagaacct     2820

ggaatacccc agcgtgaccc tgcctcctca gcctcacaca aaagaaggcg tggacgccta     2880

caacgaagtg atcgccagag tgagaatgtg ggtcaacctg aacctgtggc agaagctgaa     2940

actgtccagg gacgacgcca agcctctgct gagactgaag ggcttcccta gcttccctct     3000

ggtggaaaga caggccaatg aagtggattg gtgggacatg gtctgcaacg tgaagaagct     3060

gatcaacgag aagaaagagg atggcaaggt tttctggcag aacctggccg gctacaagag     3120

acaagaagcc ctgaggcctt acctgagcag cgaagaggac cggaagaagg gcaagaagtt     3180

cgccagatac cagctgggcg acctgctgct gcacctggaa aagaagcacg gcgaggactg     3240

gggcaaagtg tacgatgagg cctgggagag aatcgacaag aaggtggaag gcctgagcaa     3300

gcacattaag ctggaagagg aaagaaggag cgaggacgcc caatctaaag ccgctctgac     3360

cgattggctg agagccaagg ccagctttgt gatcgagggc ctgaaagagg ccgacaagga     3420

cgagttctgc agatgcgagc tgaagctgca gaagtggtac ggcgatctga gaggcaagcc     3480

cttcgccatt gaggccgaga acagcatcct ggacatcagc ggcttcagca agcagtacaa     3540

ctgcgccttc atttggcaga aagacggcgt caagaaactg aacctgtacc tgatcatcaa     3600

ttacttcaaa ggcggcaagc tgcggttcaa gaagatcaaa cccgaggcct tcgaggctaa     3660

cagattctac accgtgatca acaaaaagtc cggcgagatc gtgcccatgg aagtgaactt     3720

caacttcgac gaccccaacc tgattatcct gcctctggcc ttcggcaaga gacagggcag     3780

agagttcatc tggaacgatc tgctgagcct ggaaaccggc tctctgaagc tggccaatgg     3840

cagagtgatc gagaaaaccc tgtacaacag gagaaccaga caggacgagc ctgctctgtt     3900

tgtggccctg accttcgaga gaagagaggt gctggacagc agcaacatca agcccatgaa     3960

cctgatcggc gtggaccggg gcgagaatat ccctgctgtg atcgccctga cagaccctga     4020

aggatgccca ctgagcagat tcaaggactc cctgggcaac cctacacaca tcctgagaat     4080

cggcgagagc tacaaagaga agcagaggac aatccaggcc aagaaagagg tggaacagag     4140

aagagccggc ggatactcta ggaagtacgc cagcaaggcc aagaatctgg ccgacgacat     4200

ggtccgaaac accgccagag atctgctgta ctacgccgtg acacaggacg ccatgctgat     4260

cttcgagaat ctgagcagag gcttcggccg gcagggcaag agaaccttta tggccgagag     4320

gcagtacacc agaatggaag attggctcac agctaaactg gcctacgagg gactgagcaa     4380

gacctacctg tccaaaacac tggcccagta tacctccaag acctgcagca attgcggctt     4440

caccatcacc agcgccgact acgacagagt gctggaaaag ctcaagaaaa ccgccaccgg     4500

ctggatgacc accatcaacg gcaaagagct gaaggttgag ggccagatca cctactacaa     4560

caggtacaag aggcagaacg tcgtgaagga tctgagcgtg gaactggaca gactgagcga     4620

agagagcgtg aacaacgaca tcagcagctg gacaaagggc agatcaggcg aggctctgag     4680

cctgctgaag aagaggttta gccacagacc tgtgcaagag aagttcgtgt gcctgaactg     4740

cggcttcgag acacacgccg atgaacaggc tgccctgaac attgccagaa gctggctgtt     4800

cctgagaagc caagagtaca agaagtacca gaccaacaag accaccggca acaccgacaa     4860

gagggccttt gtggaaacct ggcagagctt ctacagaaaa aagctgaaag aagtctggaa     4920

gcccgccgtg actagtccaa aaaagaagag aaaggtagcc ctcgagtacc catatgatgt     4980

ccctgactac gcttga                                                     4996


<210>  968
<211>  5401
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP59 plasmid sequence

<400>  968
atggccgctg tggaaggcga tctggacgtg caagccctga ccgatctgtt caacaacctg       60

ggcatcaacc gggacccccg gcaccgggaa gtgatcgccc tgcggatgac aggcggctgg      120

tggggccctg ccaccagata caacctgatc accgtgctgc tgcaggatga tcagggtcag      180

cctcttcagc agccccggtg gcgggccgag ggccgggccg ccaaccccgc tgtgatgctg      240

accctggaag ccccatggca ggacctgcgg atggcctttg acaacgtcga cctggccgac      300

gacacactgc ggtttggccc tctggctaac ggcaattaca tccccggcga cgagtacagc      360

ctggagttca tccctcccgc catgcaagag atcgcccaaa tgcagagaga tgagctggaa      420

aacgtgctgg acattgtggg ccagatcaca atgcagatga gcgacctgat cggaatgcag      480

gacgcccaga tccggggcct ggagggccaa atcagaggcc tgagaggcaa tctgcccgtg      540

gccggaacac caccacctcc tcctccaagc ctggacctgc agcctgccgc cgccagcagc      600

ccttacgtgg cccctgcgtc tagcgctcct gccgcacccg tggcctctgc tgatctgggc      660

tggttcgccg ggggaccttc cccaggctct gtggaccctc ggctggcccg ggtcgcctac      720

aaccccttcc tgcccggacc tagcgacggc agcggcgtgg ccccggtgca gccctccgcc      780

cctcctgccg ccagccctct gctgcccctg ccacctgctc agcctgtgca gccagtgatc      840

cagtacgtgc accctcctcc tatgaaccct gcccagcaga ttattcctat ccagcacatc      900

agagccgtga ccggcaacgc ccccaccaac cctagagaga tccctatgtg gatcggcaga      960

aacgccagcg ccatcgaggg cgtgttcccc atgaccaccc ctgatctgag gtgtcgggtg     1020

atcaacgccc tgctcggcgg caacctgggc ctgaacctgg aaccacagca ctgcgtgacc     1080

tgggccagcg caatcgccac cctgtacgtt agaacccacg gcagctaccc catccaccag     1140

ctggctgaag tgctgagagg cgtggctaat agcgagggag ttgctgccgc ttatcagctg     1200

ggcatgatgc tgacaaaccg ggattacaac ctgatctggg ggatcatccg ccctctgctg     1260

cccggccagg ccgtcgtgac cgccatgcag catagactgg atcaggagat caacgacgcc     1320

gccagagtgg cctctttcat caatcacctg aacggcgtgt acgagctgct gggcttgaac     1380

gccagaggcc agagcctgag aatccctgcc tctggcggac agaccacggc cggaaccagc     1440

gccggcagag gcacaagagg aagacgcagc cagcaaggca cacctggcag acagagcagc     1500

ggccagagcc agcagcaggg aagaagaagc agccagggcc agagcagaca gtcagactcc     1560

agcgaccaga acgtgcagag acaatcccag ggcggcaacg gacggggagg ctataatctg     1620

agacccagga cctaccagcc ccagagatac ggcggaggca gaggcagaag gtggaacgac     1680

cagcctgcca gatcagacaa ccagcagcgg tcccaatctc aacagcctca gtccgaggct     1740

agaggcgagc agagcagaac cagcggagcc ggcagaggac agggcggccg ggggaatcaa     1800

aacagaaacc agagaagcgc cggtggcaat gccgacagaa cagtgaacac cgtgacaacc     1860

gccagcgctt ctacaagcgc ctcaggtcaa gatggatcct ctccagctcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaattaaa agcccactgg gacagcggag ccaccattac     1980

atgcatcccc gaggcttttc tggaagatga gcagcctatc caaacaatgc tgatcaagac     2040

catccacggc gagaagcagc agaacgtgta ctacctgaca ttcaagatcc agggcagaaa     2100

ggtggaagcc gaggtgctgg cctctcctta tgactacatc ctgctcaatc cttctgatgt     2160

gccatggctg atgaaaaagc ctctgcaact gaccgtgctg gtccccctgc aggactacca     2220

ggagcggctg ctgaaacaga ccaccctgcc taaggaacag aaggaccagc tggaaaagct     2280

gttcctgaag tacgacgccc tgtggcagca ctgggagaac caggtgggcc acagaagagg     2340

tgccagaaca gtgaacaccg tgacaaccgg cggcagccca aagaagaagc ggaaggtctc     2400

tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac     2460

aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga     2520

cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag     2580

caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc     2640

catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt     2700

tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa     2760

gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta     2820

caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa     2880

cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga     2940

tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat     3000

ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag     3060

atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag     3120

cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca     3180

gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt     3240

gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc     3300

cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga     3360

cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc     3420

caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa     3480

agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag     3540

gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct     3600

gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga     3660

tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga     3720

agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc     3780

caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg     3840

cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc     3900

cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg     3960

gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg     4020

caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt     4080

gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc     4140

caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa     4200

cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa     4260

aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt     4320

cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga     4380

ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag     4440

cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa     4500

agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata     4560

ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc     4620

cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag     4680

cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat     4740

ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa     4800

aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc     4860

cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat     4920

caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca     4980

gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa     5040

cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag     5100

gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca     5160

cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga     5220

gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga     5280

aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag     5340

tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg     5400

a                                                                     5401


<210>  969
<211>  5401
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP60 plasmid sequence

<400>  969
atggccgcca tcgagggcga tctggacgtg caggccctgg ctaacctgtt caacgacctg       60

ggcatcaaca gaaaccccag acacagagag gtgattgccc tgagaatgac cggcggctgg      120

tggggccccg ctaccagata taatctggtg agcctgctgc tgcaggacga ccagggccag      180

cctctgccac agcccagatg gcgggctgaa ggcagagccg caaaccccgc cgtgatgttc      240

accctggaag ccccctggca ggatctgaga ctggcctttg acaatatcga cgtgggcgag      300

ggcacactga gattcggccc acttgctaac ggcaactaca tccccggcga cgagttcagc      360

ctggagttcc tgcctcctgc catgcaggag atcacacaga tgcagagaga tgagctggag      420

gaagtgctgg atgtggtggg ccagatcaca atgcagatga acgacctgat cggcatgcag      480

gacgcccaga tccggggact ggaaggacaa ctgagaggac tgagaggcaa tctgccagtg      540

gccggcacac ctccacctcc tccacccagc ctggacctgc agcctgctgc cgccagcagc      600

ccctacgtgg cccctgcacc ttccgctcct gctgcctctg ccgccgcagc cgacctggga      660

tggttcgccg gaggccctgg ccctggatct ctggaccccc gcctcgcccg ggtggcctac      720

aacccctttc tgcctggccc tagcgacggc agcggtgccg ctcccgccca gcctagcgct      780

cctccggtgg cctctcctct gccttctctg ctgcctgccc agcccatgca acctgtgatc      840

cagtacgtgc accccccacc tatcaatcct gctcaacagg tgatccctat tcagcatatc      900

agagccgtga ccggcaacgc ccctagcaac ccaagagaaa tccctatgtg gatcggaaga      960

aacgccagcg ccatcgaggg cgtgttcccc atccctacat ctgacatccg ttctagagtg     1020

atcaacgccc tgctgggtag acagctgggc ctgaacctgg atcctcagca ctgcatcacc     1080

tgggccagcg caatcgccac tctgtacgtg cgcacccacg gcagctaccc tctgcaccag     1140

ctggccgagg ttctgcggag agtctccaac agcgaaggcg cggccgccgc ctggcagctg     1200

ggcatgatgc tgaccaacca ggactacaac ctcgtgtggg gaatggtcag acccctgctg     1260

cccggccagg ctgtggtcac cgccatgcag caccggctgg atcaggaggt ttctgatgcc     1320

gccagaatcg tgtccttcgt gaaccacctg aacgccgtgt acgagctgct gggcctgaat     1380

gccagaggcc agaacctcag ggtctccacc ggcggccaga ccaccgctag aacaagcgcc     1440

ggcagaggcg ccagaggcag acggtcccag caggggaccc ctggcaggca gtctagcgga     1500

caggcccctc ctcaaggccg gagaagcagc cagggccagc agcctaggca gtctgagagc     1560

ggcgaccaga acaaccagcg gcagctccag ggaggaaaca accggggcgg ctataacctg     1620

cggcctcgga cataccagcc tcagcggtac gggggaggcc ggggccggag atggaacgat     1680

cagaccgcca gagccgataa ccagcagcgg agccaatccc aacaacctca gagcgaggcc     1740

cggggcgagc agagcagaac cagcggcgcc ggcagagaac agggcggcag aggcaatcaa     1800

aatcggaatc aaagatctgc cggagaaaac accgacagat ccgtgaacac cgtgacagcc     1860

accagcgcca gcatcagcgc ctcaggtcaa aatggatcct ctacaactcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaattaaa agcccactgg gatagcggag ctacaatcac     1980

ctgcgtgccc gaggcctttc tggaagatga gagacctatc cagaccatgc tgatcaagac     2040

catccacggc gagaagcagc aggacgtcta ctacctgacc ttcaaggtgc agggcagaaa     2100

ggtggaagcc gaggtgctgg cctctcctta tgactacatc ctgctcaacc ccagcgacgt     2160

gccttggctg atgaaaaagc ctctgcagct gacagtgctg gtgccactgc acgagtacca     2220

ggagcggctg ctgcaacaaa ccgccctgcc taaggaacag aaagagctgc tgcagaagct     2280

gttcctgaag tacgacgccc tgtggcagca ttgggaaaac caggtgggcc accggagagg     2340

tgccagatcc gtgaacaccg tgacagccgg cggcagccca aagaagaagc ggaaggtctc     2400

tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac     2460

aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga     2520

cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag     2580

caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc     2640

catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt     2700

tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa     2760

gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta     2820

caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa     2880

cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga     2940

tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat     3000

ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag     3060

atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag     3120

cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca     3180

gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt     3240

gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc     3300

cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga     3360

cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc     3420

caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa     3480

agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag     3540

gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct     3600

gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga     3660

tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga     3720

agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc     3780

caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg     3840

cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc     3900

cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg     3960

gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg     4020

caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt     4080

gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc     4140

caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa     4200

cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa     4260

aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt     4320

cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga     4380

ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag     4440

cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa     4500

agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata     4560

ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc     4620

cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag     4680

cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat     4740

ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa     4800

aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc     4860

cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat     4920

caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca     4980

gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa     5040

cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag     5100

gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca     5160

cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga     5220

gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga     5280

aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag     5340

tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg     5400

a                                                                     5401


<210>  970
<211>  5811
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP61 plasmid sequence

<400>  970
atggggcaag aattaagcca gcatgaacgt tatgtagaac aattgaagca ggctttaaag       60

acacggggag taaaggttaa atatgctgat cttttgaaat tttttgattt tgtgaaggat      120

acttgtcctt ggtttccgca agagggaacc atagatatta aacggtggcg tagagtaggc      180

gactgtttcc aagactatta caatactttt ggcccggaga aagtcccagt aactgcattc      240

tcttactgga acttaattaa agaattgata gataagaaag aagttaaccc acaagtaatg      300

gctgccgtag cccaaactga agaaatttta aaaagtaatt ctcaaacaga cctcacaaag      360

acctctcaaa acccagactt ggaccttatt tcccttgata gcgacgatga aggagctaaa      420

agttcctctc tacaagataa aggtttatca agtactaaaa aaccaaaaag attcccagtt      480

ctgttaacag cacaaactag taaagaccct gaagacccca acccctcaga ggtagactgg      540

gacggcttgg aagatgaggc agcgaaatat cataatcccg attggcctcc cttcctaacc      600

cgtccacctc cttacaataa agctactcct tccgcaccca ctgtaatggc ggttgttaat      660

ccaaaagagg agctcaaaga aaaaattgct caattagagg aacagattaa attagaagag      720

ttacaccagg cactaatttc caaattacaa aaactaaaaa cagggaatga aactgtaact      780

cacccagaca cagcaggagg cctttctcgc acgcctcact ggccagggca acatatccct      840

aaaggaaaat gttgcgccag tcgagaaaag gaagaacaaa tcccaaaaga tattttccca      900

gtgactgaaa ccgttgatgg gcaaggtcaa gcctggagac accataatgg ttttgatttt      960

gccgtcataa aagaattaaa aacagctgct tcccaatatg gggctactgc cccatacaca     1020

ttagccatag tggaatctgt agcggacaat tggcttaccc ctacagattg gaatacgctt     1080

gttagggcag tcctctcagg aggagatcac ttactgtgga aatctgagtt ttttgaaaat     1140

tgcagagata cggctaaaag aaaccaacaa gccggtaatg gctgggattt tgacatgtta     1200

acaggttcgg gtaattattc cagcaccgat gcacaaatgc agtatgatcc aggattgttt     1260

gctcaaattc aagcggctgc tacaaaagcc tggagaaaac ttcccgttaa gggagaccca     1320

ggagcctccc ttacaggagt caaacaagga cccgatgagc catttgcaga tttcgtacac     1380

agacttataa caactgctgg gagaatcttt ggaagtgctg aggccggtgt agactatgta     1440

aaacaactag catatgaaaa tgctaatcca gcttgtcagg cagccattcg cccctataga     1500

aagaagacag atttaactgg ctatatccgt ctttgctcgg atattgggcc ctcttatcag     1560

caaggcctgg ccatggccgc cgcctttagc gggcagactg taaaagattt tcttaacaac     1620

aaaaataaag agaaaggagg gtgttgcttt aaatgcggta aaaaaggaca ctttgcaaaa     1680

aattgtcatg aacatgcaca taacaatgct gaaccaaaag ttcccggact ctgccctaga     1740

tgtaaaagag ggaaacattg ggccaatgaa tgcaaatcca aaactgataa tcaaggaaac     1800

ccaataccac cccatcaggg aaacggggcc agccccaggc cccgaaacaa gcttatgggg     1860

cagtcagctt tgttccagcc aacaaaaaca acccatttca aagcttacca gagccacccc     1920

aggaagtgca ggattggacc tctgttccac ctcccacaca gtattaacgc ctgaaatggg     1980

gccccaagcg ttaagcactg gaatatatgg accactgcct cccaacactt ttggattaat     2040

cctaggccga agtagcatta ctatgaaggg tctacaagtt tatccaggag taattgataa     2100

tgactatacc ggagaaatta aaattatggc aaaagctgtt aacaatattg ttactgtctc     2160

tcaaggcaac agaatagctc aattaatcct cctgcctctg atcgagacag acaataaggt     2220

acaacaacct tatagaggac aaggaagttt tggatcctca gacatatatt gggtccaacc     2280

tattacttgt caaaaacctt ccttaacatt atggttagat gacaaaatgt tcacaggctt     2340

aatagatacg ggggctgatg tcacaattat caagctggag gactggcctc ctaattggcc     2400

tataacagat accttaacca atttaagagg aataggacaa agtaacaacc ctaaacaaag     2460

ttctaaatat cttacttgga gagataaaga aaacaattct ggtctcatca aaccgtttgt     2520

tattcctaac ttacctgtca atctttgggg ccgagattta ctttctcaaa tgaaaattat     2580

gatgtgtagc cccaatgaca tagtaactgc tcaaatgtta gcccagggct acagcccagg     2640

aaaagggtta ggaaaaaagg aaaatggcat tctacatcct atcccaaatc aaggacaatc     2700

taacaaaaaa ggttttggaa atttttaact gcggccattg acatacttgg tgccccacag     2760

gtgatggctg ctgtcgccgg cggcagccca aagaagaagc ggaaggtctc tagacaagag     2820

atcaagagaa tcaacaagat cagaaggaga ctggtcaagg acagcaacac aaagaaggcc     2880

ggcaagacag gccccatgaa aaccctgctc gtcagagtga tgacccctga cctgagagag     2940

cggctggaaa acctgagaaa gaagcccgag aacatccctc agcctatcag caacaccagc     3000

agggccaacc tgaacaagct gctgaccgac tacaccgaga tgaagaaagc catcctgcac     3060

gtgtactggg aagagttcca gaaagacccc gtgggcctga tgagcagagt tgctcagcct     3120

gccagcaaga agatcgacca gaacaagctg aagcccgaga tggacgagaa gggcaatctg     3180

accacagccg gctttgcctg ctctcagtgt ggccagcctc tgttcgtgta caagctggaa     3240

caggtgtccg agaaaggcaa ggcctacacc aactacttcg gcagatgtaa cgtggccgag     3300

cacgagaagc tgattctgct ggcccagctg aaacctgaga aggactctga tgaggccgtg     3360

acctacagcc tgggcaagtt tggacagaga gccctggact tctacagcat ccacgtgacc     3420

aaagaaagca cacaccccgt gaagcccctg gctcagatcg ccggcaatag atacgcctct     3480

ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa caatcgccag cttcctgagc     3540

aagtaccagg acatcatcat cgagcaccag aaggtggtca agggcaacca gaagagactg     3600

gaaagcctga gggagctggc cggcaaagag aacctggaat accccagcgt gaccctgcct     3660

cctcagcctc acacaaaaga aggcgtggac gcctacaacg aagtgatcgc cagagtgaga     3720

atgtgggtca acctgaacct gtggcagaag ctgaaactgt ccagggacga cgccaagcct     3780

ctgctgagac tgaagggctt ccctagcttc cctctggtgg aaagacaggc caatgaagtg     3840

gattggtggg acatggtctg caacgtgaag aagctgatca acgagaagaa agaggatggc     3900

aaggttttct ggcagaacct ggccggctac aagagacaag aagccctgag gccttacctg     3960

agcagcgaag aggaccggaa gaagggcaag aagttcgcca gataccagct gggcgacctg     4020

ctgctgcacc tggaaaagaa gcacggcgag gactggggca aagtgtacga tgaggcctgg     4080

gagagaatcg acaagaaggt ggaaggcctg agcaagcaca ttaagctgga agaggaaaga     4140

aggagcgagg acgcccaatc taaagccgct ctgaccgatt ggctgagagc caaggccagc     4200

tttgtgatcg agggcctgaa agaggccgac aaggacgagt tctgcagatg cgagctgaag     4260

ctgcagaagt ggtacggcga tctgagaggc aagcccttcg ccattgaggc cgagaacagc     4320

atcctggaca tcagcggctt cagcaagcag tacaactgcg ccttcatttg gcagaaagac     4380

ggcgtcaaga aactgaacct gtacctgatc atcaattact tcaaaggcgg caagctgcgg     4440

ttcaagaaga tcaaacccga ggccttcgag gctaacagat tctacaccgt gatcaacaaa     4500

aagtccggcg agatcgtgcc catggaagtg aacttcaact tcgacgaccc caacctgatt     4560

atcctgcctc tggccttcgg caagagacag ggcagagagt tcatctggaa cgatctgctg     4620

agcctggaaa ccggctctct gaagctggcc aatggcagag tgatcgagaa aaccctgtac     4680

aacaggagaa ccagacagga cgagcctgct ctgtttgtgg ccctgacctt cgagagaaga     4740

gaggtgctgg acagcagcaa catcaagccc atgaacctga tcggcgtgga ccggggcgag     4800

aatatccctg ctgtgatcgc cctgacagac cctgaaggat gcccactgag cagattcaag     4860

gactccctgg gcaaccctac acacatcctg agaatcggcg agagctacaa agagaagcag     4920

aggacaatcc aggccaagaa agaggtggaa cagagaagag ccggcggata ctctaggaag     4980

tacgccagca aggccaagaa tctggccgac gacatggtcc gaaacaccgc cagagatctg     5040

ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg agaatctgag cagaggcttc     5100

ggccggcagg gcaagagaac ctttatggcc gagaggcagt acaccagaat ggaagattgg     5160

ctcacagcta aactggccta cgagggactg agcaagacct acctgtccaa aacactggcc     5220

cagtatacct ccaagacctg cagcaattgc ggcttcacca tcaccagcgc cgactacgac     5280

agagtgctgg aaaagctcaa gaaaaccgcc accggctgga tgaccaccat caacggcaaa     5340

gagctgaagg ttgagggcca gatcacctac tacaacaggt acaagaggca gaacgtcgtg     5400

aaggatctga gcgtggaact ggacagactg agcgaagaga gcgtgaacaa cgacatcagc     5460

agctggacaa agggcagatc aggcgaggct ctgagcctgc tgaagaagag gtttagccac     5520

agacctgtgc aagagaagtt cgtgtgcctg aactgcggct tcgagacaca cgccgatgaa     5580

caggctgccc tgaacattgc cagaagctgg ctgttcctga gaagccaaga gtacaagaag     5640

taccagacca acaagaccac cggcaacacc gacaagaggg cctttgtgga aacctggcag     5700

agcttctaca gaaaaaagct gaaagaagtc tggaagcccg ccgtgactag tccaaaaaag     5760

aagagaaagg tagccctcga gtacccatat gatgtccctg actacgcttg a              5811


<210>  971
<211>  5077
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP62 plasmid sequence

<400>  971
atgggccaaa tcttttcccg tagcgctagc cctattccgc gaccgccccg ggggctggcc       60

gctcatcact ggcttaactt cctccaggcg gcatatcgcc tagaacccgg tccctccaat      120

tgcgctttcc acctgttaag aagatatcat gaaacagttt ccggaatacc ggctcggatc      180

tgtcccatta actactccct cctagccagc ctactcccaa aaggataccc cggccgggtg      240

aatgaaattt tacacatact catccaaacc caagcccaga tcccgtcccg tcccgcgcca      300

ccgccgccgt catcccccac ccacgacccc ccggattctg atccacaaat cccccctccc      360

tatgttgagc ctacggcccc ccaagtcctt ccagtcatgc atccacatgg tgctcctcct      420

aaccatcgcc catggcaaat gaaagaccta caggccatta agcaagaagt ctcccaagca      480

gcccctggga gcccccagtt tatgcagacc atccggcttg cggtgcagca gtttgacccc      540

actgccaaag acctccaaga cctcctgcag tacctttgct cctccctcgt ggcttccctc      600

catcaccagc agctagatag ccttatatca gaggccgaaa cccgaggtat tacaggttat      660

aacccattag ccggtcccct ccgtgtccaa gccaacaatc cacaacaaca aggattaagg      720

cgagaatacc agcaactctg gctcgccgcc ttcgccgccc tgccggggag tgccaaagac      780

ccttcctggg cctctatcct ccaaggcctg gaggagcctt accacgcctt cgtagaacgc      840

ctcaacatag ctcttgacaa tgggctgcca gaaggcacgc ccaaagaccc catcttacgt      900

tccttagcct actccaatgc aaacaaagaa tgccaaaaat tactacaggc ccgaggacac      960

actaatagcc ctctaggaga tatgttgcgg gcttgtcaga cctggacccc caaagacaaa     1020

accaaagtgt tagttgtcca gcctaaaaaa ccccccccaa atcagccgtg cttccggtgc     1080

gggaaagcag gccactggag tcgggactgc actcagcctc gtcccccccc cgggccatgc     1140

cccctatgtc aagacccaac tcactggaag cgagactgcc cccgcctaaa gcccactatc     1200

ccagaaccag agccagagga agatgccctc ctattagacc tccccgctga cattccacac     1260

ccaaaaaact ccataggggg ggaggtttaa cctccccccc cacattacag caagtctttc     1320

ttaaccaaga cccagcatct attctgccag ttataccgtt agatcccgcc cgtcggcccg     1380

taattaaagc ccaggttgac acccagacca gccacccaaa gactatcgaa gctctactag     1440

atacaggagc agacatgaca gtccttccga tagccttgtt ctcaagtaat actcccctca     1500

aaaatacatc cgtattaggg gcagggggcc aaacccaaga tcactttaag ctcacctccc     1560

ttcctgtgct aatacgcctc cctttccgga caacgcctat tgttttaaca tcttgcctag     1620

ttgataccaa aaacaactgg gccatcatag gtcgcgatgc cttacaacaa tgccagggcg     1680

tcctgtacct ccctgaggca aaagggccgc ctgtaatctt gccaatacag gcgccagccg     1740

tccttggact agaacacctc ccaaggcccc cccaaatcag ccagttccct ttaaaccaga     1800

acgcctccag gccttgcaac acttggtccg gaaggccctg gaggcaggcc atatcgaatc     1860

ctacaccggg ccaggaaata acccagtatt cccagttaaa aaggccaatg gaacctggcg     1920

attcatccac gacctgcggg ccactaactc tctaaccata gacctctcat catcttcccc     1980

cgggccccct gacttgtcca gcctgccaac cacacgtgcc cctcaagtgc tgccagtgat     2040

gcacggcggc agcccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa     2100

caagatcaga aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc     2160

catgaaaacc ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct     2220

gagaaagaag cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa     2280

caagctgctg accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga     2340

gttccagaaa gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat     2400

cgaccagaac aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt     2460

tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa     2520

aggcaaggcc tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat     2580

tctgctggcc cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg     2640

caagtttgga cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca     2700

ccccgtgaag cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa     2760

agccctgtcc gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat     2820

catcatcgag caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga     2880

gctggccggc aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac     2940

aaaagaaggc gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct     3000

gaacctgtgg cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa     3060

gggcttccct agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat     3120

ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca     3180

gaacctggcc ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga     3240

ccggaagaag ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga     3300

aaagaagcac ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa     3360

gaaggtggaa ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc     3420

ccaatctaaa gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg     3480

cctgaaagag gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta     3540

cggcgatctg agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag     3600

cggcttcagc aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact     3660

gaacctgtac ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa     3720

acccgaggcc ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat     3780

cgtgcccatg gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc     3840

cttcggcaag agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg     3900

ctctctgaag ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag     3960

acaggacgag cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag     4020

cagcaacatc aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt     4080

gatcgccctg acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa     4140

ccctacacac atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc     4200

caagaaagag gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc     4260

caagaatctg gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt     4320

gacacaggac gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa     4380

gagaaccttt atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact     4440

ggcctacgag ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa     4500

gacctgcagc aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa     4560

gctcaagaaa accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga     4620

gggccagatc acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt     4680

ggaactggac agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg     4740

cagatcaggc gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga     4800

gaagttcgtg tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa     4860

cattgccaga agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa     4920

gaccaccggc aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa     4980

aaagctgaaa gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc     5040

cctcgagtac ccatatgatg tccctgacta cgcttga                              5077


<210>  972
<211>  4871
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP63 plasmid sequence

<400>  972
atgggcgcga gaaactccgt cttgtcaggg aaggaagcag atgaattaga aaaagttagg       60

ttacggccca acggaaagaa aaagtatatg ttgaagcatg tagtatgggc agcaaatgaa      120

ttggacagat ttggattagc agaaagcctg ttggataaca aagaaggttg tcaaaaaatt      180

ctttcagttt tagctccatt agttccgaca ggttcagaaa acttaaagag cctttataat      240

actgtctgcg tcatttggtg cattcacgca gaagagaaag tgaaacatac tgaggaagca      300

aaacaaatag tgcagagaca tctagtggtg gaaacaggaa cagcagacag aatgccagca      360

acaagcagac caacagcacc acctagtggc agaggaggaa attacccagt gcagcaagta      420

ggtggcaatt atgtccacct acccttaagt ccaagaacat taaatgcttg ggtaaaatta      480

gtagaagaga aaaaatttgg ggcagaggta gtgccaggat ttcaagcgct atcagaaggc      540

tgcactccct atgatattaa tcaaatgcta aattgtgtag gagaacatca ggcagccatg      600

caaattatta gagagattat aaatgaagaa gctgccgatt gggatttaca acacccgcaa      660

ccaggtccac taccagcagg gcaacttaga gagccaagag gatcagacat tgcaggaact      720

actagtacag tagatgaaca aatccaatgg atgtacaggc aacaaaaccc cataccagta      780

ggcaacattt atagaaggtg gatccaatta gggctgcaga aatgtgtaag aatgtataac      840

ccaacaaaca ttttagatgt gaaacaagga ccaaaagagc catttcaaag ctacgtagat      900

agattctaca aaagtctaag agcagagcaa acagatcccg cagtaaagaa ttggatgacc      960

caaacactgc tgattcaaaa tgctaaccca gattgtaaac tagtgctcaa gggtctgggc     1020

atgaatccca ctttagaaga aatgctgaca gcctgtcagg gagtaggagg gccaggacaa     1080

aaagctaggt taatggcaga agcattgaaa gaggcactga ggccagatca actcccattt     1140

gcagcagtcc aacagaaagg acaaaggaag acaatcaagt gttggaattg tggaaaggag     1200

ggacactctg caaaacaatg cagggcccct agaagacagg gctgctggaa gtgtggaaaa     1260

acgggtcatg ttatggccaa atgccctgaa agacaggcgg gttttttagg gcttggccca     1320

tggggaaaga agccccgcaa tttccccatg gcccagatgc ctcaggggct gataccaact     1380

gctcccccag aggatccagc tgtggatcta ctgaagaatt acatgaagat gggcagaaag     1440

cagagggaga acagagagag accttacaag gaggtgacag aggatttgct gcacctcaat     1500

tctctctttg gagaagacca gtagtcactg cctacattga agaacagccc gtagaagtat     1560

tattagatac aggggctgac gattcaattg tagcagggat agaattgggt ccaaattata     1620

cccctaaaat agtaggagga ataggaggct tcattaacac caaagaatat aaagatgtaa     1680

aaataaaagt cttaggcaag gtaattaagg gaacaattat gacgggagat accccaatta     1740

atatttttgg cagaaatttg ctaacagcta tgggcatgtc tttaaatctc cccatagcta     1800

aggtggaggg tgccggcggc aactaccccg tgcagcaagg cggcagccca aagaagaagc     1860

ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg     1920

acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga     1980

tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc     2040

agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga     2100

tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga     2160

tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga     2220

tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc     2280

tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg     2340

gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga     2400

aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact     2460

tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg     2520

ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa     2580

caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca     2640

agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat     2700

accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg     2760

aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt     2820

ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg     2880

aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca     2940

acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag     3000

aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca     3060

gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca     3120

aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca     3180

ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt     3240

ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt     3300

tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg     3360

ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg     3420

ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact     3480

tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat     3540

tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact     3600

tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt     3660

tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag     3720

tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg     3780

ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga     3840

tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat     3900

gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg     3960

agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa cagagaagag     4020

ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc     4080

gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg     4140

agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt     4200

acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct     4260

acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca     4320

tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga     4380

tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt     4440

acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga     4500

gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc     4560

tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct     4620

tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga     4680

gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg     4740

cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg     4800

ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat gatgtccctg     4860

actacgcttg a                                                          4871


<210>  973
<211>  4805
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP88 plasmid sequence

<400>  973
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccaaag aagaagcgga     1800

aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg gtcaaggaca     1860

gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc agagtgatga     1920

cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac atccctcagc     1980

ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac accgagatga     2040

agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg ggcctgatga     2100

gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag cccgagatgg     2160

acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc cagcctctgt     2220

tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac tacttcggca     2280

gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa cctgagaagg     2340

actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc ctggacttct     2400

acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct cagatcgccg     2460

gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc atgggaacaa     2520

tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag gtggtcaagg     2580

gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac ctggaatacc     2640

ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc tacaacgaag     2700

tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg aaactgtcca     2760

gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct ctggtggaaa     2820

gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag ctgatcaacg     2880

agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag agacaagaag     2940

ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag ttcgccagat     3000

accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac tggggcaaag     3060

tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc aagcacatta     3120

agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg accgattggc     3180

tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag gacgagttct     3240

gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag cccttcgcca     3300

ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac aactgcgcct     3360

tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc aattacttca     3420

aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct aacagattct     3480

acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac ttcaacttcg     3540

acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc agagagttca     3600

tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat ggcagagtga     3660

tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg tttgtggccc     3720

tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg aacctgatcg     3780

gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct gaaggatgcc     3840

cactgagcag attcaaggac tccctgggca accctacaca catcctgaga atcggcgaga     3900

gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag agaagagccg     3960

gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac atggtccgaa     4020

acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg atcttcgaga     4080

atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag aggcagtaca     4140

ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc aagacctacc     4200

tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc ttcaccatca     4260

ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc ggctggatga     4320

ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac aacaggtaca     4380

agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc gaagagagcg     4440

tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg agcctgctga     4500

agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac tgcggcttcg     4560

agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg ttcctgagaa     4620

gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac aagagggcct     4680

ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg aagcccgccg     4740

tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat gtccctgact     4800

acgct                                                                 4805


<210>  974
<211>  2413
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pStx42.174.12.7 plasmid sequence

<400>  974
gctagctagg tctagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt       60

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa      120

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt      180

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa      240

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac      300

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt      360

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt      420

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat      480

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac      540

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg      600

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc      660

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa      720

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag      780

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct      840

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat      900

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa      960

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     1020

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     1080

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     1140

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     1200

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     1260

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     1320

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     1380

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     1440

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     1500

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     1560

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     1620

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     1680

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     1740

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     1800

ccgacaggcc cgaaggaata gaagaagaag gtggagagag agacagagac agatccattc     1860

gattagtgaa cggatctcga cggtatcgcc tttaaaagaa aaggggggat tggggggtac     1920

agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa agaactacaa     1980

aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag agatccagtt     2040

tgagggccta tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga     2100

gataattgga attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag     2160

aaagtaataa tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca     2220

tatgcttacc gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg     2280

acgaaacacc actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc     2340

gtagtgggta aagctccctc ttcggaggga gcatcaaagc tgcattctag ttgtggtttt     2400

tttttttgaa ttc                                                        2413


<210>  975
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 plasmid sequence

<400>  975
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  976
<211>  4794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP127 plasmid sequence

<400>  976
atggaagccg tgatcaaggt gatcagctcc gcatgcaaga cctactgtgg caagacgagc       60

ccaagcaaga aggaaatcgg cgctatgctg agcctgctgc agaaggaggg cctcctgatg      120

agcctgtctg atctgtacag cccaggtagc tgggacccta tcaccgccgc cctgacacag      180

agagccatgg tgctgggcaa aagcggcgag ctgaagacat ggggactggt gctgggcgcc      240

ctgaaagccg ctagagaaga gcaagtaacc agcgagcagg ccaagttctg gctgggactg      300

ggcggcggta gagtgagccc ccctggccct gagtgcatcg agaagcctgc caccgagcgg      360

cgcattgaca aaggcgaaga agtgggcgag acaaccgtgc agagagacgc caagatggct      420

ccagaagaga cagcaacccc aaagaccgtg ggcaccagct gctaccactg cggcaccgct      480

atcggctgca actgcgccac cgccagcgcg cctcctcccc cgtatgtggg cagcggcctc      540

tacccctccc tggcaggagt gggagagcag cagggccagg gcggagatac acccagaggc      600

gccgagcagc ctagagccga acccggccac gccggccagg cccctggccc cgccctgacc      660

gactgggcca gaatcagaga ggagctggcc tctacaggcc ctccagtggt cgccatgcct      720

gtggtgatca agaccgaggg acctgcctgg acccctctgg aacctaaact gattacacgg      780

ctggctgata ccgtcagaac caagggcctc agaagcccca tcacaatggc cgaagtggaa      840

gccctgatga gcagcccact gctgcctcac gacgtgacca acctgatgcg ggtgatcctg      900

ggccccgccc cttacgccct gtggatggac gcctggggcg tgcagctgca aacagttatc      960

gccgccgcca caagagaccc ccggcaccca gccaacggcc agggcagagg cgagagaaca     1020

aacctggatc ggctgaaggg cctcgccgat ggcatggccg gcaatcctga gggccaggct     1080

gctctgctga gacccgggga actggttgct atcaccgcca gcgccctgca ggccttcaga     1140

gaagtggccc ggctggccga gcctacagac ccctgggccg agatcaccca gggcccttct     1200

gagagcttcg tggacttcgc caacagactg atcaaggccg ttgagggctc cgacctgcct     1260

cctagcgccc gcgcccccgt gatcatcgac tgttttagac agaaatcgca acccgacatc     1320

cagcagctga tccgggccgc tccttctacc ctgaccacac ctggcgagat catcaagtac     1380

gtgctggaca gacagaagac cgcccccctg accgacagag gaatcgccgc cgccatgtct     1440

agcgccattc agcctctggt gatggccgtg gtcaacagag aaagagatgg acagacaggt     1500

tctggcggca gagcccgggg cctgtgctac acctgcggat cccctggaca ctaccaggcc     1560

cagtgtccta agaaaagaaa gtctggtaac agcagagagc ggtgccagct gtgtgatggc     1620

atgggccaca acgccaaaca gtgccggaga cgggacggaa accaaggaca aagacccggc     1680

cggggactga gcagcggacc ttggcctgtc agccagcaac ctgccgtgtc cggtgccacc     1740

agctgctacc actgcggcac cggcggcagc ccaaagaaga agcggaaggt ctctagacaa     1800

gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag     1860

gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga     1920

gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc     1980

agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg     2040

cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag     2100

cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat     2160

ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg     2220

gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc     2280

gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc     2340

gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg     2400

accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc     2460

tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg     2520

agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga     2580

ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg     2640

cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg     2700

agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag     2760

cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     2820

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     2880

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     2940

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     3000

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     3060

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     3120

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     3180

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     3240

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     3300

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     3360

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     3420

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     3480

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     3540

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     3600

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     3660

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     3720

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     3780

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     3840

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     3900

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     3960

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     4020

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     4080

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     4140

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     4200

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     4260

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     4320

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     4380

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     4440

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     4500

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     4560

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     4620

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     4680

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa     4740

aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga           4794


<210>  977
<211>  4320
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP128 plasmid sequence

<400>  977
atgggcaact ctcctagcta caatccccct gccggcatct ccccatctga ctggctgaac       60

ctgctgcagt ccgcccagcg cctgaatcca aggcctagcc catccgactt cacagatctg      120

aagaactata tccactggtt tcacaagacc cagaagaagc cttggacctt cacaagcgga      180

ggaccaacat cctgcccacc aggcagattt ggaagggtgc cactggtgct ggccaccctg      240

aacgaggtgc tgtccaatga gggaggagca cctggagcct ctgccccaga ggagcagcct      300

ccaccctacg accctccagc catcctgccc atcatctccg agggaaacag gaataggcac      360

agggcatggg cactgaggga gctgcaggat atcaagaagg agatcgagaa taaggcccct      420

ggctctcaag tgtggatcca gacactgcgg ctggccatcc tgcaggcaga cccaacccct      480

gcagatctgg agcagctgtg ccagtacatc gccagccctg tggaccagac cgcccacatg      540

acatccctga ccgcagcaat cgcagcagca gaggcagcaa cacccagcag agtgctgacc      600

cctaagaccg gcacactgac ccagcagtct gcccagccaa acgcaggcga tctgaggagc      660

cagtatcaga atctgtggct gcaggccggc aagatctccc tgctggtgct gcagctgcag      720

ccctggtcta ccatcgtgca gggacctgca gagagctccg tggagtttgt gaaccgcctg      780

cagatctccc tggccgacaa cctgccagat ggcgtgctgc ggaatcccct gctgacacct      840

ctggtcatgc agatgctgac cgagtctgtg agcaagttct gcaggggaga ggccagcgga      900

aggggaggag ccaagacagc aggactgaga accatcggac cacctaggat gaagcagcct      960

gccctgctgg tgcacacccc aggaccaaag atgcctggac cacgccagcc agcacctaag     1020

aggccaccac ctggaccttg ctacagatgt ctgaaggagg gacactgggc cagggactgc     1080

ccaacaaagg caaccggccc accacctgga ccatgcccca tctgtaagga cccaagccac     1140

tggaagcgcg attgtcccac actgaagtcc aagaatctaa tagagggggg acttagcgcc     1200

ccccaaacca taacacctat aacagattct cttagtgagg ccgaattaga atgcttaggt     1260

gccccagcca tcctgcccat catctccggc ggcagcccaa agaagaagcg gaaggtctct     1320

agacaagaga tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca     1380

aagaaggccg gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac     1440

ctgagagagc ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc     1500

aacaccagca gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc     1560

atcctgcacg tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt     1620

gctcagcctg ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag     1680

ggcaatctga ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac     1740

aagctggaac aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac     1800

gtggccgagc acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat     1860

gaggccgtga cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc     1920

cacgtgacca aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga     1980

tacgcctctg gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc     2040

ttcctgagca agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag     2100

aagagactgg aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg     2160

accctgcctc ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc     2220

agagtgagaa tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac     2280

gccaagcctc tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc     2340

aatgaagtgg attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa     2400

gaggatggca aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg     2460

ccttacctga gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg     2520

ggcgacctgc tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat     2580

gaggcctggg agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa     2640

gaggaaagaa ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc     2700

aaggccagct ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc     2760

gagctgaagc tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc     2820

gagaacagca tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg     2880

cagaaagacg gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc     2940

aagctgcggt tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg     3000

atcaacaaaa agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc     3060

aacctgatta tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac     3120

gatctgctga gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa     3180

accctgtaca acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc     3240

gagagaagag aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac     3300

cggggcgaga atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc     3360

agattcaagg actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa     3420

gagaagcaga ggacaatcca ggccaagaaa gaggtggaac agagaagagc cggcggatac     3480

tctaggaagt acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc     3540

agagatctgc tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc     3600

agaggcttcg gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg     3660

gaagattggc tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa     3720

acactggccc agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc     3780

gactacgaca gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc     3840

aacggcaaag agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag     3900

aacgtcgtga aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac     3960

gacatcagca gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg     4020

tttagccaca gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac     4080

gccgatgaac aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag     4140

tacaagaagt accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa     4200

acctggcaga gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgactagt     4260

ccaaaaaaga agagaaaggt agccctcgag tacccatatg atgtccctga ctacgcttga     4320


<210>  978
<211>  4407
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP129 plasmid sequence

<400>  978
atggtgtctc tggacaggga tatggcaagg caggtgagcg gaggcaagag ggattaccca       60

gagctggaga agtgcatcaa gcacgcctgt aagatcaagg tgcggctgag aggagagcac      120

ctgaccgagg gcaactgcct gtggtgtctg aagacactgg actatatgtt cgaggatcac      180

aaggaggagc cctggaccaa ggtgaagttt agaacaatct ggcagaaggt gaagaacctg      240

acccctgagg agagcaataa gaaggacttc atgtccctgc aggccacact ggccggcctg      300

atgtgctgtc agatgggcat gaggccagag accctgcagg acgccatggc cacagtgatc      360

atgaaggatg gcctgctgga gcaggaggag aagaaggagg ataagcgcga gaaggaggag      420

agcgtgtttc caatcgtggt gcaggcagca ggaggccggt cctggaaggc cgtggactct      480

gtgatgttcc agcagctgca gaccgtggca atgcagcacg gactggtgag cgaggatttt      540

gagagacagc tggcctacta tgccaccaca tggacatcca aggacatcct ggaggtgctg      600

gccatgatgc ccggcaacag agcccagaag gagctgatcc agggcaagct gaatgaggag      660

gccgagaggt ggcggagaaa caatccacct ccaccagcag gaggaggact gaccgtggat      720

cagatcatgg gagtgggaca gacaaaccag gcagcagcac aggcaaatat ggaccaggcc      780

agacagatct gcctgcagtg ggtcatcaac gcactgaggg ccgtgagaca catggcacac      840

aggcccggca accctatgct ggtgaagcag aagaccaatg agccttacga ggacttcgcc      900

gccagactgc tggaggccat cgatgccgag ccagtgacac agcccatcaa ggactacctg      960

aagctgaccc tgagctatac aaatgcctcc gccgactgcc agaagcagat ggatagaacc     1020

ctgggacaga gggtgcagca ggcctccgtg gaggagaaga tgcaggcctg tagggatgtg     1080

ggctctgagg gctttaagat gcagctgctg gcccaggccc tgaggcctgg caagggcaag     1140

ggaaacggac agccacagcg gtgctacaat tgtggcaagc caggacacca ggcaaggcag     1200

tgcaggcagg gcatcatatg tcacaactgt ggaaagagag gacatatgca aaaagaatgc     1260

agaggaaaga gagacataag gggaaaacag cagggaaacg ggaggagggg gatacgtgtg     1320

gtgccgtccg ctcctcctat ggaaggtgcc gcaggaggcc ggtcctggaa ggccggcggc     1380

agcccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa caagatcaga     1440

aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc catgaaaacc     1500

ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct gagaaagaag     1560

cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa caagctgctg     1620

accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga gttccagaaa     1680

gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat cgaccagaac     1740

aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt tgcctgctct     1800

cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa aggcaaggcc     1860

tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat tctgctggcc     1920

cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg caagtttgga     1980

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag     2040

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc     2100

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag     2160

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc     2220

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc     2280

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg     2340

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     2400

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     2460

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     2520

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     2580

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     2640

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     2700

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     2760

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     2820

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     2880

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     2940

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     3000

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     3060

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     3120

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     3180

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     3240

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     3300

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     3360

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     3420

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     3480

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     3540

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     3600

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     3660

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     3720

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     3780

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     3840

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     3900

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     3960

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     4020

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     4080

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     4140

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     4200

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     4260

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     4320

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc cctcgagtac     4380

ccatatgatg tccctgacta cgcttga                                         4407


<210>  979
<211>  4521
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP130 plasmid sequence

<400>  979
atgggcgatc ctctgacatg gagcaaggcc ctgaagaagc tggagaaggt gaccgtgcag       60

ggcagccaga agctgaccac aggcaactgc aattgggccc tgtccctggt ggacctgttc      120

cacgatacaa actttgtgaa ggagaaggat tggcagctgc gcgacgtgat cccactgctg      180

gaggacgtga cccagacact gtctggccag gagcgggagg ccttcgagag aacctggtgg      240

gccatcagcg ccgtgaagat gggcctgcag atcaacaatg tggtggatgg caaggcctct      300

tttcagctgc tgagggccaa gtacgagaag aagacagcca acaagaagca gtctgagcct      360

agcgaggagt atccaatcat gatcgacggc gccggcaacc ggaatttcag accactgacc      420

cccagaggct acaccacatg ggtgaacaca atccagacca acggcctgct gaatgaggcc      480

tcccagaatc tgttcggcat cctgagcgtg gattgtacct ccgaggagat gaatgccttt      540

ctggacgtgg tgccaggaca ggcaggacag aagcagatcc tgctggacgc catcgataag      600

atcgccgacg attgggataa ccggcaccca ctgcccaatg cacctctggt ggcaccacct      660

cagggaccta tcccaatgac agccaggttt atcaggggac tgggagtgcc acgggagaga      720

cagatggagc ccgccttcga ccagtttagg cagacctacc gccagtggat catcgaggcc      780

atgagcgagg gcatcaaagt gatgatcggc aagccaaagg cacagaacat caggcaggga      840

gccaaggagc cctatcctga gttcgtggat agactgctgt cccagatcaa gtctgagggc      900

caccctcagg agatctccaa gtttctgacc gacacactga ccatccagaa cgccaatgag      960

gagtgccgga atgccatgcg gcacctgaga ccagaggata ccctggagga gaagatgtac     1020

gcctgtagag acatcggcac cacaaagcag aagatgatgc tgctggccaa ggccctgcag     1080

acaggcctgg ccggaccatt caagggaggc gccctgaagg gcggccccct gaaggccgcc     1140

cagacctgct ataactgtgg caagccagga cacctgagct cccagtgcag ggcaccaaag     1200

gtgtgcttca agtgtaagca gcctggccac ttttctaagc aatgcagaag tgttccaaaa     1260

aacgggaagc aaggggctca agggaggccc cagaaacaaa ctttcccgat acaacagaag     1320

agtcagcaca acaaatctgt tgtacaagag actcctcaga ctcaaaatct gtacccagat     1380

ctgagcgaaa taaaaaagga atacaatgtc aaggagaagg atcaagtaga ggatctcaac     1440

ctggacagtt tgtgggaggg tgccagcgag gagtatccaa tcatgatcgg cggcagccca     1500

aagaagaagc ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga     1560

ctggtcaagg acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc     1620

gtcagagtga tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag     1680

aacatccctc agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac     1740

tacaccgaga tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc     1800

gtgggcctga tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg     1860

aagcccgaga tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt     1920

ggccagcctc tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc     1980

aactacttcg gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg     2040

aaacctgaga aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga     2100

gccctggact tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg     2160

gctcagatcg ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc     2220

tgcatgggaa caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag     2280

aaggtggtca agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag     2340

aacctggaat accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac     2400

gcctacaacg aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag     2460

ctgaaactgt ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc     2520

cctctggtgg aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag     2580

aagctgatca acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac     2640

aagagacaag aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag     2700

aagttcgcca gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag     2760

gactggggca aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg     2820

agcaagcaca ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct     2880

ctgaccgatt ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac     2940

aaggacgagt tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc     3000

aagcccttcg ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag     3060

tacaactgcg ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc     3120

atcaattact tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag     3180

gctaacagat tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg     3240

aacttcaact tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag     3300

ggcagagagt tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc     3360

aatggcagag tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct     3420

ctgtttgtgg ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc     3480

atgaacctga tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac     3540

cctgaaggat gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg     3600

agaatcggcg agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa     3660

cagagaagag ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac     3720

gacatggtcc gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg     3780

ctgatcttcg agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc     3840

gagaggcagt acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg     3900

agcaagacct acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc     3960

ggcttcacca tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc     4020

accggctgga tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac     4080

tacaacaggt acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg     4140

agcgaagaga gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct     4200

ctgagcctgc tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg     4260

aactgcggct tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg     4320

ctgttcctga gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc     4380

gacaagaggg cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc     4440

tggaagcccg ccgtgactag tccaaaaaag aagagaaagg tagccctcga gtacccatat     4500

gatgtccctg actacgcttg a                                               4521


<210>  980
<211>  4674
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP131 plasmid sequence

<400>  980
atgggccaga cccacagcag acaactgttc gtgcacatgc tgtccgtgat gctgaagcac       60

agaggcatca ccgtgtctaa gcctaagctg atcaacttcc tgagcttcat cgaggaagtg      120

tgtccttggt ttccacggga aggcacagtg aacctggaaa catggaaaaa ggtgggcgaa      180

cagatcagaa cccactacac cctgcacggc cctgagaagg tgcctgtgga aacactttcc      240

ttctggaccc tgatccgcga ctgcctggat ttcgacaatg acgagctgaa aagactgggc      300

aacctgctca agcaggagga agatcctctg cacgaccctg acagcgagaa cagctacgac      360

gcccctcctc ctcctcatcc tagcctgcac tctagcagac cttccgacaa cgacgacctg      420

ctgtctagca cagacgaggc cgagctggac gaggaagccg ccaagtacca ccaggaggac      480

tggggcttcc tggctcagga gaaaggcgcc ctgacaagca aggacgagct ggtggaatgt      540

ttcaagaacc tgaccatcgc cctgcagaac gctggaatca agctgccagc caacaacgat      600

aagttcccct ccgccccccc tctgcctcct gcctacgccc ctagcgtggt ggccggactg      660

gatccacccc ccggccccct gcccccaagc aagaacatgt ctccactgca gaaagccctg      720

agacaagccc agaggctggg cgaagttgtg tccgatttca gcctggcctt ccccgtgttc      780

gagaacaaca accagcggta ctacgagagc ctgcctttca agcagctgaa ggaactcaaa      840

atcgcatgca gccagtacgg ccctaccgca ccttttacca tcgccatgat cgagaacctc      900

ggcacccagg ccctgccacc taatgattgg aagcagacag ccagagcctg cctgtcaggc      960

ggagattacc tgctgtggaa gagcgagttc ttcgagcaat gcgccagaat cgctgacgtg     1020

aaccggcagc agggcatcca gacgagctac gagatgctga tcggcgaggg accctaccag     1080

gccaccgaca cccagctgaa cttcctgcct ggggcctatg cccaaatcag caacgccgcc     1140

agacaggctt ggaagaaact gcctagctct tctacaaaga ccgaggacct gagcaaagtg     1200

cggcaaggcc ccgatgagcc ctaccaggac tttgtcgcca gactgctcga caccatcggc     1260

aagatcatga gcgacgaaaa ggccggcatg gtcctggcta agcaactggc tttcgagaat     1320

gctaatagcg cctgtcaggc cgccctgcgg ccttacagaa agaagggcga cctgtccgat     1380

tttatcagaa tctgcgccga catcggcccc tcttatatgc agggaattgc catggccgct     1440

gctctgcagg gcaaaagcat caaggaagtg cttttccagc agcaagctcg gaacaagcgg     1500

ggaagacaga gaagcggcaa tagcggttgt tttgtgtgcg gccagcccgg ccaccgcgcc     1560

gccgtgtgcc cccagaagca gcagagcccc gtgaacaccc ctaatctgtg cggtgccgac     1620

tgcctggatt tcgacaatga cggcggcagc ccaaagaaga agcggaaggt ctctagacaa     1680

gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag     1740

gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga     1800

gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc     1860

agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg     1920

cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag     1980

cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat     2040

ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg     2100

gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc     2160

gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc     2220

gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg     2280

accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc     2340

tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg     2400

agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga     2460

ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg     2520

cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg     2580

agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag     2640

cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     2700

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     2760

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     2820

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     2880

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     2940

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     3000

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     3060

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     3120

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     3180

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     3240

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     3300

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     3360

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     3420

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     3480

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     3540

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     3600

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     3660

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     3720

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     3780

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     3840

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     3900

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     3960

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     4020

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     4080

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     4140

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     4200

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     4260

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     4320

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     4380

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     4440

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     4500

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     4560

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa     4620

aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga           4674


<210>  981
<211>  4569
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP132 plasmid sequence

<400>  981
atgggccaga caatcacaac ccctctgagc ctgaccctgg accactggag tgaagtgcgg       60

gctagagccc acaaccaggg cgtggaagtc cggaaaaaaa agtggatcac cctgtgcgag      120

gccgagtggg tcatgatgaa cgtgggatgg cctagagagg gtacatttag cctggacaac      180

atcagccagg ttgagaaaaa gattttcgct cctggccctt acggccatcc tgaccaggtg      240

ccttacatca ccacatggcg gagcctggct accgacccac caagctgggt gcggcccttc      300

ctgcctcctc ccaagccccc cacccctctg cctcagcctc tgagccccca gccctctgcc      360

cctctgacca gctctctgta ccctgtgctg cctaagtccg atccccctaa acctcctgtt      420

ttacctcccg accctagcag cccactgatc gacctgctga cggaagaacc tcctccttat      480

cctggcggac atggcccccc accttctggc cctcggaccc caaccgcctc ccctatcgcc      540

tctagactga gagagcggag agaaaacccc gccgaagagt cccaagccct gcccctgaga      600

gagggcccta acaaccggcc tcagtactgg cccttcagcg ccagcgatct gtataactgg      660

aagtcccaca atcctccttt cagccaggat cctgtggccc tgacaaacct gatcgagtct      720

atcctggtga ctcaccagcc aacctgggat gactgccagc agctgctgca ggccctcctg      780

accggcgaag agagacagag agtgctgctg gaggccagaa agcaggtgcc tggagaggac      840

ggcaggccta cccagctgcc taatgtgatc gacgagacat tccccctgac cagaccaaat      900

tgggacttcg ccaccccagc tggcagagag cacctgcgcc tgtaccggca gcttctgctg      960

gccggactga gaggcgctgc cagaagacca accaacctgg ctcaggtgaa gcaggtcgtg     1020

cagggcaaag aggagacacc cgccgctttc ctggaacggc tgaaggaggc ctacagaatg     1080

tacacccctt acgaccccga agatccagga caggccgcca gcgtgatcct gagcttcatc     1140

taccagagca gccctgacat cagaaacaag ctgcagcggc tggaaggcct gcagggcttc     1200

acactgagcg acctgctcaa ggaggccgag aagatctaca acaagcggga aacccctgag     1260

gaaagagaag agagattgtg gcagcggcaa gaggagcggg acaaaaagcg gcacaaggaa     1320

atgaccaagg tgctggctac cgtggtggcc cagaacagag ataaagacag agaggaatcg     1380

aagctgggcg accagagaaa gatccccctt ggcaaggacc aatgtgccta ctgcaaggaa     1440

aaaggccact gggtgaggga ctgtcccaag agacccagaa agaagcccgc aaacagcaca     1500

ctgctgggtg ccagctctct gtaccctgtg ctgcctggcg gcagcccaaa gaagaagcgg     1560

aaggtctcta gacaagagat caagagaatc aacaagatca gaaggagact ggtcaaggac     1620

agcaacacaa agaaggccgg caagacaggc cccatgaaaa ccctgctcgt cagagtgatg     1680

acccctgacc tgagagagcg gctggaaaac ctgagaaaga agcccgagaa catccctcag     1740

cctatcagca acaccagcag ggccaacctg aacaagctgc tgaccgacta caccgagatg     1800

aagaaagcca tcctgcacgt gtactgggaa gagttccaga aagaccccgt gggcctgatg     1860

agcagagttg ctcagcctgc cagcaagaag atcgaccaga acaagctgaa gcccgagatg     1920

gacgagaagg gcaatctgac cacagccggc tttgcctgct ctcagtgtgg ccagcctctg     1980

ttcgtgtaca agctggaaca ggtgtccgag aaaggcaagg cctacaccaa ctacttcggc     2040

agatgtaacg tggccgagca cgagaagctg attctgctgg cccagctgaa acctgagaag     2100

gactctgatg aggccgtgac ctacagcctg ggcaagtttg gacagagagc cctggacttc     2160

tacagcatcc acgtgaccaa agaaagcaca caccccgtga agcccctggc tcagatcgcc     2220

ggcaatagat acgcctctgg acctgtgggc aaagccctgt ccgatgcctg catgggaaca     2280

atcgccagct tcctgagcaa gtaccaggac atcatcatcg agcaccagaa ggtggtcaag     2340

ggcaaccaga agagactgga aagcctgagg gagctggccg gcaaagagaa cctggaatac     2400

cccagcgtga ccctgcctcc tcagcctcac acaaaagaag gcgtggacgc ctacaacgaa     2460

gtgatcgcca gagtgagaat gtgggtcaac ctgaacctgt ggcagaagct gaaactgtcc     2520

agggacgacg ccaagcctct gctgagactg aagggcttcc ctagcttccc tctggtggaa     2580

agacaggcca atgaagtgga ttggtgggac atggtctgca acgtgaagaa gctgatcaac     2640

gagaagaaag aggatggcaa ggttttctgg cagaacctgg ccggctacaa gagacaagaa     2700

gccctgaggc cttacctgag cagcgaagag gaccggaaga agggcaagaa gttcgccaga     2760

taccagctgg gcgacctgct gctgcacctg gaaaagaagc acggcgagga ctggggcaaa     2820

gtgtacgatg aggcctggga gagaatcgac aagaaggtgg aaggcctgag caagcacatt     2880

aagctggaag aggaaagaag gagcgaggac gcccaatcta aagccgctct gaccgattgg     2940

ctgagagcca aggccagctt tgtgatcgag ggcctgaaag aggccgacaa ggacgagttc     3000

tgcagatgcg agctgaagct gcagaagtgg tacggcgatc tgagaggcaa gcccttcgcc     3060

attgaggccg agaacagcat cctggacatc agcggcttca gcaagcagta caactgcgcc     3120

ttcatttggc agaaagacgg cgtcaagaaa ctgaacctgt acctgatcat caattacttc     3180

aaaggcggca agctgcggtt caagaagatc aaacccgagg ccttcgaggc taacagattc     3240

tacaccgtga tcaacaaaaa gtccggcgag atcgtgccca tggaagtgaa cttcaacttc     3300

gacgacccca acctgattat cctgcctctg gccttcggca agagacaggg cagagagttc     3360

atctggaacg atctgctgag cctggaaacc ggctctctga agctggccaa tggcagagtg     3420

atcgagaaaa ccctgtacaa caggagaacc agacaggacg agcctgctct gtttgtggcc     3480

ctgaccttcg agagaagaga ggtgctggac agcagcaaca tcaagcccat gaacctgatc     3540

ggcgtggacc ggggcgagaa tatccctgct gtgatcgccc tgacagaccc tgaaggatgc     3600

ccactgagca gattcaagga ctccctgggc aaccctacac acatcctgag aatcggcgag     3660

agctacaaag agaagcagag gacaatccag gccaagaaag aggtggaaca gagaagagcc     3720

ggcggatact ctaggaagta cgccagcaag gccaagaatc tggccgacga catggtccga     3780

aacaccgcca gagatctgct gtactacgcc gtgacacagg acgccatgct gatcttcgag     3840

aatctgagca gaggcttcgg ccggcagggc aagagaacct ttatggccga gaggcagtac     3900

accagaatgg aagattggct cacagctaaa ctggcctacg agggactgag caagacctac     3960

ctgtccaaaa cactggccca gtatacctcc aagacctgca gcaattgcgg cttcaccatc     4020

accagcgccg actacgacag agtgctggaa aagctcaaga aaaccgccac cggctggatg     4080

accaccatca acggcaaaga gctgaaggtt gagggccaga tcacctacta caacaggtac     4140

aagaggcaga acgtcgtgaa ggatctgagc gtggaactgg acagactgag cgaagagagc     4200

gtgaacaacg acatcagcag ctggacaaag ggcagatcag gcgaggctct gagcctgctg     4260

aagaagaggt ttagccacag acctgtgcaa gagaagttcg tgtgcctgaa ctgcggcttc     4320

gagacacacg ccgatgaaca ggctgccctg aacattgcca gaagctggct gttcctgaga     4380

agccaagagt acaagaagta ccagaccaac aagaccaccg gcaacaccga caagagggcc     4440

tttgtggaaa cctggcagag cttctacaga aaaaagctga aagaagtctg gaagcccgcc     4500

gtgactagtc caaaaaagaa gagaaaggta gccctcgagt acccatatga tgtccctgac     4560

tacgcttga                                                             4569


<210>  982
<211>  4410
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP133 plasmid sequence

<400>  982
atgggtcaga ttttcagcag aagcgcctcc cctattccta gacctccacg gggcctggcc       60

gcccaccact ggctgaattt cctgcaggcc gcttatagac tggagcctgg accttccagc      120

tacgacttcc accagctgaa gaaattcctg aagatcgccc tggaaacccc tgccagaatc      180

tgccctatca actacagcct gctggcctcc ctgctgccca agggctaccc tggcagagtg      240

aacgagatcc ttcatatcct gatccagaca caggctcaga tcccctctag gcccgctcca      300

cctcctccaa gcagcccaac ccacgatcct cctgatagcg accctcagat ccccccacca      360

tacgtggagc ccaccgcccc tcaagtgctg ccagtgatgc acccccacgg cgcccctcct      420

aatcacagac cttggcagat gaaagacctg caggccatca agcaggaagt gtcccaggcc      480

gctcctggca gcccccaatt tatgcagacc atcagactcg ccgttcagca gttcgacccc      540

acagccaagg atctgcagga cctgctgcag tacctgtgta gcagcctggt cgccagcctg      600

caccatcagc aactggattc tctgatcagc gaggccgaga caagaggcat caccggctac      660

aaccctctgg ccggccccct gcgggtgcag gcaaacaacc cccagcagca ggggctgcgg      720

agagagtacc agcagctgtg gctggctgct ttcgccgcac tgcctggaag cgccaaagat      780

ccatcttggg cctctatcct gcagggcctg gaagaacctt accacgcctt tgtggaaaga      840

ctgaacatcg ccctggacaa cggcctgcct gagggcaccc ctaaggaccc catcctgaga      900

tctctggcct acagcaacgc caacaaggaa tgtcagaagc tgctgcaagc cagaggccac      960

accaacagcc ccctgggcga catgctgcgc gcctgccaga cctggacccc taaggacaag     1020

accaaggtgc tggtggtgca gcctaagaag cctcccccta atcagccctg cttccggtgc     1080

ggcaaggccg gacactggag ccgggactgc acccagcctc ggcctccacc gggaccttgt     1140

cctctgtgcc aagaccccac acactggaag agagattgcc cccgcctaaa gcccactatc     1200

ccagaaccag agccagagga agatgccctc ctattagacc tccccgctga cattccacac     1260

ccaaaaaact ccataggggg ggagggttta acctctcctc ctaccctgca gcaggtgttc     1320

ctgaatcaag atcctgccag catcctgggt gcccctcaag tgctgccagt gatgcacggc     1380

ggcagcccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc     1440

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa     1500

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag     1560

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg     1620

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag     1680

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag     1740

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc     1800

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag     1860

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg     1920

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt     1980

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg     2040

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg     2100

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc     2160

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc     2220

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa     2280

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg     2340

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     2400

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     2460

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     2520

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     2580

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     2640

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     2700

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     2760

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     2820

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     2880

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     2940

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     3000

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     3060

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     3120

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     3180

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     3240

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     3300

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     3360

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     3420

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     3480

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     3540

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     3600

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     3660

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     3720

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     3780

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     3840

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     3900

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     3960

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     4020

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     4080

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     4140

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     4200

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     4260

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     4320

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt agccctcgag     4380

tacccatatg atgtccctga ctacgcttga                                      4410


<210>  983
<211>  4407
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP134 plasmid sequence

<400>  983
atgggccaaa tcttttcccg tagcgctagc cctattccgc gaccgccccg ggggctggcc       60

gctcatcact ggcttaactt cctccaggcg gcatatcgcc tagaacccgg tccctccaat      120

tgcgctttcc acctgttaag aagatatcat gaaacagttt ccggaatacc ggctcggatc      180

tgtcccatta actactccct cctagccagc ctactcccaa aaggataccc cggccgggtg      240

aatgaaattt tacacatact catccaaacc caagcccaga tcccgtcccg tcccgcgcca      300

ccgccgccgt catcccccac ccacgacccc ccggattctg atccacaaat cccccctccc      360

tatgttgagc ctacggcccc ccaagtcctt ccagtcatgc atccacatgg tgctcctcct      420

aaccatcgcc catggcaaat gaaagaccta caggccatta agcaagaagt ctcccaagca      480

gcccctggga gcccccagtt tatgcagacc atccggcttg cggtgcagca gtttgacccc      540

actgccaaag acctccaaga cctcctgcag tacctttgct cctccctcgt ggcttccctc      600

catcaccagc agctagatag ccttatatca gaggccgaaa cccgaggtat tacaggttat      660

aacccattag ccggtcccct ccgtgtccaa gccaacaatc cacaacaaca aggattaagg      720

cgagaatacc agcaactctg gctcgccgcc ttcgccgccc tgccggggag tgccaaagac      780

ccttcctggg cctctatcct ccaaggcctg gaggagcctt accacgcctt cgtagaacgc      840

ctcaacatag ctcttgacaa tgggctgcca gaaggcacgc ccaaagaccc catcttacgt      900

tccttagcct actccaatgc aaacaaagaa tgccaaaaat tactacaggc ccgaggacac      960

actaatagcc ctctaggaga tatgttgcgg gcttgtcaga cctggacccc caaagacaaa     1020

accaaagtgt tagttgtcca gcctaaaaaa ccccccccaa atcagccgtg cttccggtgc     1080

gggaaagcag gccactggag tcgggactgc actcagcctc gtcccccccc cgggccatgc     1140

cccctatgtc aagacccaac tcactggaag cgagactgcc cccgcctaaa gcccactatc     1200

ccagaaccag agccagagga agatgccctc ctattagacc tccccgctga cattccacac     1260

ccaaaaaact ccataggggg ggaggtttta acctcccccc ccacattaca gcaagtcttt     1320

cttaaccaag acccagcatc tattctggcc cctcaagtgc tgccagtgat gcacggcggc     1380

agcccaaaga agaagcggaa ggtctctaga caagagatca agagaatcaa caagatcaga     1440

aggagactgg tcaaggacag caacacaaag aaggccggca agacaggccc catgaaaacc     1500

ctgctcgtca gagtgatgac ccctgacctg agagagcggc tggaaaacct gagaaagaag     1560

cccgagaaca tccctcagcc tatcagcaac accagcaggg ccaacctgaa caagctgctg     1620

accgactaca ccgagatgaa gaaagccatc ctgcacgtgt actgggaaga gttccagaaa     1680

gaccccgtgg gcctgatgag cagagttgct cagcctgcca gcaagaagat cgaccagaac     1740

aagctgaagc ccgagatgga cgagaagggc aatctgacca cagccggctt tgcctgctct     1800

cagtgtggcc agcctctgtt cgtgtacaag ctggaacagg tgtccgagaa aggcaaggcc     1860

tacaccaact acttcggcag atgtaacgtg gccgagcacg agaagctgat tctgctggcc     1920

cagctgaaac ctgagaagga ctctgatgag gccgtgacct acagcctggg caagtttgga     1980

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag     2040

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc     2100

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag     2160

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc     2220

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc     2280

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg     2340

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     2400

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     2460

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     2520

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     2580

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     2640

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     2700

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     2760

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     2820

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     2880

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     2940

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     3000

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     3060

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     3120

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     3180

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     3240

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     3300

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     3360

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     3420

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     3480

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     3540

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     3600

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     3660

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     3720

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     3780

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     3840

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     3900

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     3960

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     4020

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     4080

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     4140

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     4200

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     4260

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     4320

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggtagc cctcgagtac     4380

ccatatgatg tccctgacta cgcttga                                         4407


<210>  984
<211>  4677
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP135 plasmid sequence

<400>  984
atgggccaga ccgtgaccac acccctgtcc ctgacactgg gccactggaa ggacgtggag       60

cggatcgccc acaatcagtc tgtggatgtg aagaagcgga gatgggtgac cttctgcagc      120

gccgagtggc ccaccttcaa cgtgggctgg ccaagggacg gcaccttcaa ccgcgatctg      180

atcacacagg tgaagatcaa ggtgtttagc ccaggacctc acggacaccc agaccaggtg      240

ccttatatcg tgacctggga ggccctggcc ttcgatccac ctccatgggt gaagccattt      300

gtgcacccaa agccacctcc accactgcct ccatccgccc cttctctgcc actggagcca      360

cctcggtcca ccccaccaag aagctccctg tatcctgccc tgacaccatc tctgggcgcc      420

aagccaaagc cacaggtgct gtctgacagc ggaggacctc tgatcgacct gctgaccgag      480

gatcctccac cctacagaga tccaaggcct ccaccatccg acagggatgg aaacggagga      540

gaggcaacac cagcaggaga ggcccctgac ccatccccca tggcctctag actgaggggc      600

aggcgcgagc ctccagtggc agatagcacc acatcccagg cattcccact gagggcagga      660

ggaaatggcc agctgcagta ttggcccttt tctagctccg acctgtacaa ctggaagaac      720

aataacccat ccttctctga ggatcccggc aagctgaccg ccctgatcga gagcgtgctg      780

atcacccacc agcccacatg ggacgattgt cagcagctgc tgggcaccct gctgacaggc      840

gaggagaagc agcgggtgct gctggaggca aggaaggccg tgagaggcga cgatggcaga      900

cccacccagc tgcctaatga ggtggacgca gcatttccac tggagaggcc agactgggat      960

tataccacac aggccggcag gaaccacctg gtgcactaca ggcagctgct gctggccgga     1020

ctgcagaatg caggcaggtc ccctaccaac ctggccaagg tgaagggcat cacacagggc     1080

cctaatgaga gcccatccgc ctttctggag cgcctgaagg aggcctaccg gagatatacc     1140

ccctacgacc ctgaggatcc aggccaggag acaaacgtgt ctatgagctt catctggcag     1200

tctgccccag acatcggaag gaagctggag cgcctggagg acctgaagaa taagaccctg     1260

ggcgatctgg tgcgggaggc agagaagatc ttcaacaaga gagagacacc tgaggagagg     1320

gaggagcgga tcaggaggga gaccgaggag aaggaggagc ggagaaggac agaggacgag     1380

cagaaggaga aggagcggga tcgccggaga cacagagaga tgagcaagct gctggccacc     1440

gtggtgtccg gacagaagca ggacaggcag ggaggagaga ggcgccggtc tcagctggac     1500

cgcgatcagt gcgcctactg taaggagaag ggccactggg ccaaggattg ccccaagaag     1560

cctagaggcc caaggggccc taggccacag accagcctgc tgacactgga cgatggtgcc     1620

agctccctgt atcctgccct gacaggcggc agcccaaaga agaagcggaa ggtctctaga     1680

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     1740

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     1800

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     1860

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     1920

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     1980

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     2040

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     2100

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     2160

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     2220

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     2280

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     2340

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     2400

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     2460

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     2520

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     2580

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     2640

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     2700

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     2760

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     2820

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     2880

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     2940

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     3000

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     3060

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     3120

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     3180

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     3240

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     3300

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     3360

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     3420

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     3480

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     3540

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     3600

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     3660

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     3720

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     3780

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     3840

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     3900

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     3960

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     4020

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     4080

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     4140

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     4200

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     4260

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     4320

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     4380

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     4440

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     4500

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     4560

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     4620

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        4677


<210>  985
<211>  5274
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP136 plasmid sequence

<400>  985
atgggcgtgt ccggctcaaa gggccagaag ctgtttgtgt ccgtgctgca gcgtctgctg       60

tccgaacggg gcctacacgt gaaagagagc agcgccatcg agttctacca gtttctgatc      120

aaggtgtcac cctggttccc cgaggaaggc ggcctgaatc tgcaggattg gaagagagtg      180

ggcagagaaa tgaagaagta cgccgctgag cacggcaccg acagcatccc caagcaggct      240

tatcctatct ggctgcaact gagagagatc ctgacagagc aatctgacct ggtgctgctg      300

agcgccgagg ccaagtccgt gacagaggaa gaactggaag aaggcctgac aggactgctg      360

agcgccagca gccaggagaa gacctacggc acaagaggca ccgcctatgc cgaaatcgac      420

accgaggtgg ataagctgag cgagcacatc tacgacgagc cctacgagga gaaggaaaag      480

gccgacaaga acgaggagaa ggaccacgtg cggaaggtca agaagatcgt gcaaagaaag      540

gaaaatagcg agcataagag aaaggagaaa gatcagaagg ccttcctggc aaccgactgg      600

aacaacgacg acctgagccc tgaggactgg gacgacctgg aagagcaggc cgcccactac      660

cacgatgacg acgaactgat cctgcctgtg aagagaaagg tggacaagaa gaagccgctc      720

gccctgaggc ggaaacctct gcccccggtt ggcttcgccg gagccatggc cgaggctaga      780

gagaagggcg atctgacctt cacatttccc gtggttttca tgggagaatc cgacgacgat      840

gatacccctg tgtgggaacc tctgcccctg aagacactga aggaactgca gtctgccgtg      900

cggaccatgg gccctagcgc cccttacacc ctccaggtgg tggacatggt tgcctctcag      960

tggctgacac ctagcgattg gcaccaaacc gccagagcca ccctgtctcc tggggactac     1020

gtgctgtggc ggaccgagta cgaggagaag agcaaggaaa ccgtgcagaa gaccgctggc     1080

aagcggaaag gcaaggtgag cctggatatg ctgctgggca caggtcagtt cctgagccct     1140

tcttctcaga tcaagctttc taaagatgtg ctgaaggatg tgaccaccaa cgccgtcctg     1200

gcctggagag ccatccctcc tccaggcgtc aaaaagacag tgctggccgg actcaagcag     1260

ggaaatgagg aaagctacga gacattcatc agcagactgg aagaggccgt gtacagaatg     1320

atgcctagag gagaaggcag cgacatcctg atcaagcagc tggcttggga gaacgctaat     1380

tctctgtgcc aggacctgat ccggcctatg cggaagaccg gcaccatgca ggactacatc     1440

agagcctgtc tggatgcctc ccctgccgtg gtgcagggca tggcctacgc cgccgcaatg     1500

agaggacaaa agtacagcac cttcgtgaaa cagacatacg gcggcggaaa aggcggacag     1560

ggctctgaag gccctgtgtg cttcagctgc ggcaaaacag gtcacattaa gcgggattgc     1620

aaggaagaga aaggaagcaa gcgcgctcct cctggactgt gtcctagatg caagaaaggc     1680

taccactgga agagcgagtg caagagcaag ttcgacaagg acggcaaccc tctgccacca     1740

ctggaaacta acgccgaaaa cagcaaaaac cccacacaga aaggcgacaa aggaaaggac     1800

agcggactga accccgaagc ccctcctttc accatccacg acctgccacg aggcacccca     1860

ggcagtgccg gcttggacct gagcagccag aaagacctga tcctgtctct ggaagacggc     1920

gtgtccctgg tgccaaccct ggtgaagggc accctgcccg agggcaccac gggactgatc     1980

atcggcagat ccagcaacta caagaaaggc ctggaggtgc tgcccggcgt gatcgactcc     2040

gacttccagg gcgaaattaa ggtcatggta aaggccgcta agaacgccgt gatcatccac     2100

aagggcgagc ggatcgcgca gctgctgctg ctgccttatc tgaaactgcc taaccctatc     2160

atcaaggagg aaagaggcag cgagggattt ggcagcacct cccacgtgca cggtgccgac     2220

ctggtgctgc tgagcgccga gggcggcagc ccaaagaaga agcggaaggt ctctagacaa     2280

gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag     2340

gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga     2400

gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc     2460

agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg     2520

cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag     2580

cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat     2640

ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg     2700

gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc     2760

gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc     2820

gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg     2880

accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc     2940

tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg     3000

agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga     3060

ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg     3120

cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg     3180

agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag     3240

cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     3300

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     3360

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     3420

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     3480

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     3540

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     3600

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     3660

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     3720

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     3780

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     3840

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     3900

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     3960

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     4020

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     4080

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     4140

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     4200

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     4260

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     4320

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     4380

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     4440

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     4500

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     4560

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     4620

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     4680

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     4740

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     4800

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     4860

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     4920

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     4980

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     5040

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     5100

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     5160

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa     5220

aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga           5274


<210>  986
<211>  5034
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP137 plasmid sequence

<400>  986
atgggccagg agctgtccca gcacgagcgg tacgtggagc agctgaagca agcccttaaa       60

acaagaggcg tgaaggtgaa atacgccgac ctgctgaagt tcttcgattt tgtgaaggat      120

acctgccctt ggttccctca ggagggcacc atcgacatca agagatggcg cagagtgggc      180

gactgcttcc aagattacta caacaccttc ggacctgaga aagtgcctgt gaccgccttc      240

agctactgga acctgatcaa ggaactgatc gacaaaaagg aagtgaaccc acaggtgatg      300

gctgctgtcg cccagaccga ggaaatcctg aagagcaaca gccagacaga cctgaccaag      360

accagccaga accctgacct ggatctgatc agcctggaca gcgatgatga gggcgccaag      420

tccagcagcc tgcaggacaa gggcctgagc agcaccaaaa agcctaagcg gttccccgtc      480

ctgctgaccg cccagacaag caaggaccca gaggatccta acccaagcga ggtggactgg      540

gacggcctgg aggacgaggc cgctaagtac cacaaccctg actggccccc cttcctgaca      600

agacctccac cttacaacaa ggctacccct agcgccccta ccgtgatggc cgtggtgaac      660

cctaaagagg aactgaaaga aaagatcgcc cagctggaag agcagatcaa actggaagag      720

ctgcaccagg ccctgatttc taagctgcaa aagctgaaaa ccggcaacga gacagtcact      780

caccctgata cagccggagg cctgagcaga acaccacatt ggcccggcca gcacatccct      840

aagggcaagt gctgcgccag ccgggaaaag gaagagcaga tccccaagga tatcttccct      900

gtgaccgaaa ccgttgacgg acagggccag gcatggagac accacaatgg cttcgacttc      960

gccgtgatca aggaactgaa gacagccgcc tctcaatacg gcgccaccgc accttacacc     1020

ctggctatcg tggaatccgt cgccgacaac tggctgaccc caaccgactg gaataccctg     1080

gtgcgggccg tgctgtctgg cggcgaccac ctgctctgga agtctgagtt cttcgagaac     1140

tgtagggaca ccgctaagcg gaaccagcag gccggcaatg gatgggattt tgacatgctg     1200

accggcagcg gcaactacag ctctacagac gcccaaatgc agtacgaccc tggcctgttc     1260

gcccagattc aggccgctgc cacaaaggcc tggcggaagc tgcccgtgaa gggggatccc     1320

ggcgccagcc tgaccggcgt gaagcagggc cccgatgagc ctttcgccga cttcgtgcat     1380

agactgatca ccacagccgg cagaatcttc ggctccgccg aagccggcgt ggactacgtg     1440

aagcagctgg cttacgagaa cgccaaccct gcctgccagg ccgcaatcag accctataga     1500

aagaagacag atctgaccgg ctacatccgg ctgtgcagcg acatcggccc ttcctatcag     1560

cagggactgg ctatggccgc tgcctttagc ggccagaccg tgaaggactt cctgaacaac     1620

aagaacaagg aaaagggcgg atgttgtttt aagtgcggca agaaaggaca ctttgccaaa     1680

aactgccacg agcacgccca caacaacgcc gagcccaagg tgcccggcct gtgtcctcgg     1740

tgcaagagag gcaagcactg ggccaatgag tgcaagtcca agacagataa ccagggaaat     1800

ccaatccccc cccatcaggg aaatggtgct tctcctagac ctagaaacaa gctgatgggc     1860

caaagcgccc tgttccagcc taccaagaca acccacttca aggcctacca gagccacccc     1920

agaaagtgca gaatcggccc tctgttccac ctgccccaca gcatcaacgc cggtgcccca     1980

caggtgatgg ctgctgtcgc cggcggcagc ccaaagaaga agcggaaggt ctctagacaa     2040

gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag     2100

gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga     2160

gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc     2220

agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg     2280

cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag     2340

cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat     2400

ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg     2460

gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc     2520

gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc     2580

gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg     2640

accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc     2700

tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg     2760

agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga     2820

ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg     2880

cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg     2940

agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag     3000

cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     3060

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     3120

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     3180

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     3240

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     3300

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     3360

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     3420

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     3480

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     3540

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     3600

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     3660

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     3720

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     3780

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     3840

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     3900

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     3960

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     4020

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     4080

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     4140

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     4200

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     4260

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     4320

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     4380

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     4440

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     4500

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     4560

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     4620

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     4680

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     4740

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     4800

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     4860

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     4920

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa     4980

aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga           5034


<210>  987
<211>  5034
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP138 plasmid sequence

<400>  987
atggggcaag aattaagcca gcatgaacgt tatgtagaac aattgaagca ggctttaaag       60

acacggggag taaaggttaa atatgctgat cttttgaaat tttttgattt tgtgaaggat      120

acttgtcctt ggtttccgca agagggaacc atagatatta aacggtggcg tagagtaggc      180

gactgtttcc aagactatta caatactttt ggcccggaga aagtcccagt aactgcattc      240

tcttactgga acttaattaa agaattgata gataagaaag aagttaaccc acaagtaatg      300

gctgccgtag cccaaactga agaaatttta aaaagtaatt ctcaaacaga cctcacaaag      360

acctctcaaa acccagactt ggaccttatt tcccttgata gcgacgatga aggagctaaa      420

agttcctctc tacaagataa aggtttatca agtactaaaa aaccaaaaag attcccagtt      480

ctgttaacag cacaaactag taaagaccct gaagacccca acccctcaga ggtagactgg      540

gacggcttgg aagatgaggc agcgaaatat cataatcccg attggcctcc cttcctaacc      600

cgtccacctc cttacaataa agctactcct tccgcaccca ctgtaatggc ggttgttaat      660

ccaaaagagg agctcaaaga aaaaattgct caattagagg aacagattaa attagaagag      720

ttacaccagg cactaatttc caaattacaa aaactaaaaa cagggaatga aactgtaact      780

cacccagaca cagcaggagg cctttctcgc acgcctcact ggccagggca acatatccct      840

aaaggaaaat gttgcgccag tcgagaaaag gaagaacaaa tcccaaaaga tattttccca      900

gtgactgaaa ccgttgatgg gcaaggtcaa gcctggagac accataatgg ttttgatttt      960

gccgtcataa aagaattaaa aacagctgct tcccaatatg gggctactgc cccatacaca     1020

ttagccatag tggaatctgt agcggacaat tggcttaccc ctacagattg gaatacgctt     1080

gttagggcag tcctctcagg aggagatcac ttactgtgga aatctgagtt ttttgaaaat     1140

tgcagagata cggctaaaag aaaccaacaa gccggtaatg gctgggattt tgacatgtta     1200

acaggttcgg gtaattattc cagcaccgat gcacaaatgc agtatgatcc aggattgttt     1260

gctcaaattc aagcggctgc tacaaaagcc tggagaaaac ttcccgttaa gggagaccca     1320

ggagcctccc ttacaggagt caaacaagga cccgatgagc catttgcaga tttcgtacac     1380

agacttataa caactgctgg gagaatcttt ggaagtgctg aggccggtgt agactatgta     1440

aaacaactag catatgaaaa tgctaatcca gcttgtcagg cagccattcg cccctataga     1500

aagaagacag atttaactgg ctatatccgt ctttgctcgg atattgggcc ctcttatcag     1560

caaggcctgg ccatggccgc cgcctttagc gggcagactg taaaagattt tcttaacaac     1620

aaaaataaag agaaaggagg gtgttgcttt aaatgcggta aaaaaggaca ctttgcaaaa     1680

aattgtcatg aacatgcaca taacaatgct gaaccaaaag ttcccggact ctgccctaga     1740

tgtaaaagag ggaaacattg ggccaatgaa tgcaaatcca aaactgataa tcaaggaaac     1800

ccaataccac cccatcaggg aaacggggcc agccccaggc cccgaaacaa gcttatgggg     1860

cagtcagctt tgttccagcc aacaaaaaca acccatttca aagcttacca gagccacccc     1920

aggaagtgca ggattggacc tctgttccac ctcccacaca gtattaacgc cggtgcccca     1980

caggtgatgg ctgctgtcgc cggcggcagc ccaaagaaga agcggaaggt ctctagacaa     2040

gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag     2100

gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga     2160

gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc     2220

agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg     2280

cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag     2340

cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat     2400

ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg     2460

gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc     2520

gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc     2580

gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg     2640

accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc     2700

tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg     2760

agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga     2820

ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg     2880

cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg     2940

agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag     3000

cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     3060

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     3120

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     3180

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     3240

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     3300

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     3360

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     3420

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     3480

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     3540

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     3600

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     3660

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     3720

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     3780

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     3840

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     3900

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     3960

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     4020

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     4080

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     4140

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     4200

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     4260

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     4320

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     4380

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     4440

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     4500

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     4560

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     4620

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     4680

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     4740

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     4800

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     4860

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     4920

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa     4980

aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga           5034


<210>  988
<211>  4794
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP139 plasmid sequence

<400>  988
atggaggccg tgatcaaggt gatcagcagc gcatgcaaga cctactgcgg caagaccagc       60

ccatctaaga aagagatcgg cgccatgctg agcctgctcc aaaaggaagg cctgctgatg      120

agcccttccg acctgtacag ccccggaagc tgggacccaa tcaccgctgc cctgacccag      180

cgggccatgg tgctgggaaa gagcggcgag ctgaagacct ggggcctggt gctgggagcc      240

ctgaaggccg ccagagagga acaagtgaca agcgaacagg ccaagttctg gctgggactg      300

ggcggaggaa gagtcagccc tcctggccca gagtgcatcg agaagcccgc tacagagaga      360

agaatcgata agggcgaaga ggtgggcgag acaacagtgc agagagacgc caagatggct      420

cctgaggaaa ccgccacacc taagaccgtg ggcacatctt gttaccactg cggcaccgcc      480

attggatgta actgcgctac agccagcgcc cccccccctc cctacgtggg cagcggactt      540

tatcctagcc tggccggcgt gggagagcag cagggccaag gcggagatac acccagaggc      600

gccgagcagc ctagagccga acccggccac gccggactgg cccctggccc agccctgacc      660

gactgggccc gcatccggga agaactggct tctaccggcc ccccggtggt cgccatgcct      720

gtggttatca agacagaggg ccctgcttgg acccctctgg aaccaaagct gattacaaga      780

ctcgccgaca ccgtgcggac caagggcctg cggagcccta tcaccatggc cgagatggaa      840

gctctgatga gcagcccact gctgccccac gacgtgacca acctgatgag agtgatcctg      900

ggccccgccc cttacgccct gtggatggac gcctgggggg tgcagctgca gaccgtgatt      960

gccgccgcca ccagagatcc tagacaccct gctaacggcc aaggcagagg cgaaagaacc     1020

aaccttgaca gactgaaagg cctggccgat ggaatggtcg gcaacagcga aggccaggcc     1080

gccctgctga gacctggcga gctggtggct atcacagcca gcgccctgca ggccttcaga     1140

gaagtggccc gactggctga gcccacggac ccttgggccg acatcatgca gggcccttct     1200

gagagcttcg tggacttcgc caatagactg atcaaggccg tcgagggcag cgatcttcct     1260

cctagcgcga gagcccctgt tatcatcgac tgcttccggc agaaaagcca gcccgacatc     1320

caacagctga tcagagccgc cccttccacc ctgaccacac caggcgagat catcaagtac     1380

gtgctggata gacagaagac cgcccctctg accgatcagg gcatcgccgc tgccatgtcc     1440

tctgccatcc agcctctggt gatggccgtg gtgaacagag agagagacgg ccagacaggc     1500

tccggcggcc gggccagaga gctgtgctac acctgtggct ctccaggcca ctaccaggct     1560

cagtgtccta aaaagcggaa gtctggcaat tctagagagc ggtgccagct gtgcaacggc     1620

atgggccata atgccaaaca gtgtcggaaa cgggacggaa accagggcca gagaccaggc     1680

agaggcctgt cttctggccc ctggcccggc cctgagcctc ctgctgtgtc cggtgccaca     1740

tcttgttacc actgcggcac cggcggcagc ccaaagaaga agcggaaggt ctctagacaa     1800

gagatcaaga gaatcaacaa gatcagaagg agactggtca aggacagcaa cacaaagaag     1860

gccggcaaga caggccccat gaaaaccctg ctcgtcagag tgatgacccc tgacctgaga     1920

gagcggctgg aaaacctgag aaagaagccc gagaacatcc ctcagcctat cagcaacacc     1980

agcagggcca acctgaacaa gctgctgacc gactacaccg agatgaagaa agccatcctg     2040

cacgtgtact gggaagagtt ccagaaagac cccgtgggcc tgatgagcag agttgctcag     2100

cctgccagca agaagatcga ccagaacaag ctgaagcccg agatggacga gaagggcaat     2160

ctgaccacag ccggctttgc ctgctctcag tgtggccagc ctctgttcgt gtacaagctg     2220

gaacaggtgt ccgagaaagg caaggcctac accaactact tcggcagatg taacgtggcc     2280

gagcacgaga agctgattct gctggcccag ctgaaacctg agaaggactc tgatgaggcc     2340

gtgacctaca gcctgggcaa gtttggacag agagccctgg acttctacag catccacgtg     2400

accaaagaaa gcacacaccc cgtgaagccc ctggctcaga tcgccggcaa tagatacgcc     2460

tctggacctg tgggcaaagc cctgtccgat gcctgcatgg gaacaatcgc cagcttcctg     2520

agcaagtacc aggacatcat catcgagcac cagaaggtgg tcaagggcaa ccagaagaga     2580

ctggaaagcc tgagggagct ggccggcaaa gagaacctgg aataccccag cgtgaccctg     2640

cctcctcagc ctcacacaaa agaaggcgtg gacgcctaca acgaagtgat cgccagagtg     2700

agaatgtggg tcaacctgaa cctgtggcag aagctgaaac tgtccaggga cgacgccaag     2760

cctctgctga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     2820

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     2880

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     2940

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     3000

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     3060

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     3120

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     3180

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     3240

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     3300

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     3360

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     3420

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     3480

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     3540

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     3600

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     3660

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     3720

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     3780

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     3840

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     3900

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     3960

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     4020

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     4080

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     4140

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     4200

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     4260

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     4320

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     4380

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     4440

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     4500

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     4560

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     4620

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     4680

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtgac tagtccaaaa     4740

aagaagagaa aggtagccct cgagtaccca tatgatgtcc ctgactacgc ttga           4794


<210>  989
<211>  4584
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP140 plasmid sequence

<400>  989
atgggcgcca ggaacagcgt gctgtccggc aaggaggccg atgagctgga gaaggtgcgg       60

ctgagaccca atggcaagaa gaagtacatg ctgaagcacg tggtgtgggc agcaaacgag      120

ctggaccgct tcggcctggc cgagtctctg ctggataata aggagggctg ccagaagatc      180

ctgagcgtgc tggcccctct ggtgccaacc ggctctgaga acctgaagag cctgtataat      240

acagtgtgcg tgatctggtg tatccacgcc gaggagaagg tgaagcacac cgaggaggcc      300

aagcagatcg tgcagaggca cctggtggtg gagaccggca cagcagatag gatgccagcc      360

accagccgcc caacagcacc accttccgga aggggcggca actaccccgt gcagcaagtg      420

ggcggcaatt atgtgcacct gcccctgagc cctagaaccc tgaacgcctg ggtgaagctg      480

gtggaggaga agaagttcgg agcagaggtg gtgccaggat ttcaggccct gtccgagggc      540

tgcacaccct acgacatcaa ccagatgctg aattgcgtgg gagagcacca ggcagcaatg      600

cagatcatcc gggagatcat caacgaggag gcagcagact gggatctgca gcaccctcag      660

ccaggaccac tgcctgcagg acagctgcgg gagcctagag gctctgacat cgccggcacc      720

acaagcaccg tggatgagca gatccagtgg atgtacaggc agcagaaccc aatccccgtg      780

ggcaatatct atcggagatg gatccagctg ggcctgcaga agtgcgtgcg gatgtataac      840

ccaaccaata tcctggacgt gaagcagggc ccaaaggagc ccttccagag ctacgtggac      900

agattctaca agtccctgag agccgagcag acagatcccg ccgtgaagaa ctggatgacc      960

cagacactgc tgatccagaa cgccaatccc gattgcaagc tggtgctgaa gggcctgggc     1020

atgaatccta ccctggagga gatgctgaca gcatgtcagg gagtgggagg acctggacag     1080

aaggcaaggc tgatggcaga ggccctgaag gaggccctga ggcctgacca gctgccattt     1140

gccgccgtgc agcagaaggg ccagaggaag accatcaagt gctggaactg tggcaaggag     1200

ggacactctg ccaagcagtg cagggcacca aggcgccagg gatgctggaa gtgtggcaag     1260

acaggccacg tgatggccaa gtgtcctgag aggcaggcag gcttcctggg actgggacca     1320

tggggcaaga agccaagaaa ttttcctatg gcccagatgc ctcagggact gatcccaacc     1380

gcaccaccag aggacccagc agtggatctg ctgaagaact acatgaagat gggcaggaag     1440

cagcgcgaga atagggagcg cccttataag gaggtgacag aggacctgct gcacctgaac     1500

tctctctttg gagaagacca gggtgccggc ggcaactacc ccgtgcagca aggcggcagc     1560

ccaaagaaga agcggaaggt ctctagacaa gagatcaaga gaatcaacaa gatcagaagg     1620

agactggtca aggacagcaa cacaaagaag gccggcaaga caggccccat gaaaaccctg     1680

ctcgtcagag tgatgacccc tgacctgaga gagcggctgg aaaacctgag aaagaagccc     1740

gagaacatcc ctcagcctat cagcaacacc agcagggcca acctgaacaa gctgctgacc     1800

gactacaccg agatgaagaa agccatcctg cacgtgtact gggaagagtt ccagaaagac     1860

cccgtgggcc tgatgagcag agttgctcag cctgccagca agaagatcga ccagaacaag     1920

ctgaagcccg agatggacga gaagggcaat ctgaccacag ccggctttgc ctgctctcag     1980

tgtggccagc ctctgttcgt gtacaagctg gaacaggtgt ccgagaaagg caaggcctac     2040

accaactact tcggcagatg taacgtggcc gagcacgaga agctgattct gctggcccag     2100

ctgaaacctg agaaggactc tgatgaggcc gtgacctaca gcctgggcaa gtttggacag     2160

agagccctgg acttctacag catccacgtg accaaagaaa gcacacaccc cgtgaagccc     2220

ctggctcaga tcgccggcaa tagatacgcc tctggacctg tgggcaaagc cctgtccgat     2280

gcctgcatgg gaacaatcgc cagcttcctg agcaagtacc aggacatcat catcgagcac     2340

cagaaggtgg tcaagggcaa ccagaagaga ctggaaagcc tgagggagct ggccggcaaa     2400

gagaacctgg aataccccag cgtgaccctg cctcctcagc ctcacacaaa agaaggcgtg     2460

gacgcctaca acgaagtgat cgccagagtg agaatgtggg tcaacctgaa cctgtggcag     2520

aagctgaaac tgtccaggga cgacgccaag cctctgctga gactgaaggg cttccctagc     2580

ttccctctgg tggaaagaca ggccaatgaa gtggattggt gggacatggt ctgcaacgtg     2640

aagaagctga tcaacgagaa gaaagaggat ggcaaggttt tctggcagaa cctggccggc     2700

tacaagagac aagaagccct gaggccttac ctgagcagcg aagaggaccg gaagaagggc     2760

aagaagttcg ccagatacca gctgggcgac ctgctgctgc acctggaaaa gaagcacggc     2820

gaggactggg gcaaagtgta cgatgaggcc tgggagagaa tcgacaagaa ggtggaaggc     2880

ctgagcaagc acattaagct ggaagaggaa agaaggagcg aggacgccca atctaaagcc     2940

gctctgaccg attggctgag agccaaggcc agctttgtga tcgagggcct gaaagaggcc     3000

gacaaggacg agttctgcag atgcgagctg aagctgcaga agtggtacgg cgatctgaga     3060

ggcaagccct tcgccattga ggccgagaac agcatcctgg acatcagcgg cttcagcaag     3120

cagtacaact gcgccttcat ttggcagaaa gacggcgtca agaaactgaa cctgtacctg     3180

atcatcaatt acttcaaagg cggcaagctg cggttcaaga agatcaaacc cgaggccttc     3240

gaggctaaca gattctacac cgtgatcaac aaaaagtccg gcgagatcgt gcccatggaa     3300

gtgaacttca acttcgacga ccccaacctg attatcctgc ctctggcctt cggcaagaga     3360

cagggcagag agttcatctg gaacgatctg ctgagcctgg aaaccggctc tctgaagctg     3420

gccaatggca gagtgatcga gaaaaccctg tacaacagga gaaccagaca ggacgagcct     3480

gctctgtttg tggccctgac cttcgagaga agagaggtgc tggacagcag caacatcaag     3540

cccatgaacc tgatcggcgt ggaccggggc gagaatatcc ctgctgtgat cgccctgaca     3600

gaccctgaag gatgcccact gagcagattc aaggactccc tgggcaaccc tacacacatc     3660

ctgagaatcg gcgagagcta caaagagaag cagaggacaa tccaggccaa gaaagaggtg     3720

gaacagagaa gagccggcgg atactctagg aagtacgcca gcaaggccaa gaatctggcc     3780

gacgacatgg tccgaaacac cgccagagat ctgctgtact acgccgtgac acaggacgcc     3840

atgctgatct tcgagaatct gagcagaggc ttcggccggc agggcaagag aacctttatg     3900

gccgagaggc agtacaccag aatggaagat tggctcacag ctaaactggc ctacgaggga     3960

ctgagcaaga cctacctgtc caaaacactg gcccagtata cctccaagac ctgcagcaat     4020

tgcggcttca ccatcaccag cgccgactac gacagagtgc tggaaaagct caagaaaacc     4080

gccaccggct ggatgaccac catcaacggc aaagagctga aggttgaggg ccagatcacc     4140

tactacaaca ggtacaagag gcagaacgtc gtgaaggatc tgagcgtgga actggacaga     4200

ctgagcgaag agagcgtgaa caacgacatc agcagctgga caaagggcag atcaggcgag     4260

gctctgagcc tgctgaagaa gaggtttagc cacagacctg tgcaagagaa gttcgtgtgc     4320

ctgaactgcg gcttcgagac acacgccgat gaacaggctg ccctgaacat tgccagaagc     4380

tggctgttcc tgagaagcca agagtacaag aagtaccaga ccaacaagac caccggcaac     4440

accgacaaga gggcctttgt ggaaacctgg cagagcttct acagaaaaaa gctgaaagaa     4500

gtctggaagc ccgccgtgac tagtccaaaa aagaagagaa aggtagccct cgagtaccca     4560

tatgatgtcc ctgactacgc ttga                                            4584


<210>  990
<211>  4584
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP141 plasmid sequence

<400>  990
atgggcgcga gaaactccgt cttgtcaggg aaggaagcag atgaattaga aaaagttagg       60

ttacggccca acggaaagaa aaagtatatg ttgaagcatg tagtatgggc agcaaatgaa      120

ttggacagat ttggattagc agaaagcctg ttggataaca aagaaggttg tcaaaaaatt      180

ctttcagttt tagctccatt agttccgaca ggttcagaaa acttaaagag cctttataat      240

actgtctgcg tcatttggtg cattcacgca gaagagaaag tgaaacatac tgaggaagca      300

aaacaaatag tgcagagaca tctagtggtg gaaacaggaa cagcagacag aatgccagca      360

acaagcagac caacagcacc acctagtggc agaggaggaa attacccagt gcagcaagta      420

ggtggcaatt atgtccacct acccttaagt ccaagaacat taaatgcttg ggtaaaatta      480

gtagaagaga aaaaatttgg ggcagaggta gtgccaggat ttcaagcgct atcagaaggc      540

tgcactccct atgatattaa tcaaatgcta aattgtgtag gagaacatca ggcagccatg      600

caaattatta gagagattat aaatgaagaa gctgccgatt gggatttaca acacccgcaa      660

ccaggtccac taccagcagg gcaacttaga gagccaagag gatcagacat tgcaggaact      720

actagtacag tagatgaaca aatccaatgg atgtacaggc aacaaaaccc cataccagta      780

ggcaacattt atagaaggtg gatccaatta gggctgcaga aatgtgtaag aatgtataac      840

ccaacaaaca ttttagatgt gaaacaagga ccaaaagagc catttcaaag ctacgtagat      900

agattctaca aaagtctaag agcagagcaa acagatcccg cagtaaagaa ttggatgacc      960

caaacactgc tgattcaaaa tgctaaccca gattgtaaac tagtgctcaa gggtctgggc     1020

atgaatccca ctttagaaga aatgctgaca gcctgtcagg gagtaggagg gccaggacaa     1080

aaagctaggt taatggcaga agcattgaaa gaggcactga ggccagatca actcccattt     1140

gcagcagtcc aacagaaagg acaaaggaag acaatcaagt gttggaattg tggaaaggag     1200

ggacactctg caaaacaatg cagggcccct agaagacagg gctgctggaa gtgtggaaaa     1260

acgggtcatg ttatggccaa atgccctgaa agacaggcgg gttttttagg gcttggccca     1320

tggggaaaga agccccgcaa tttccccatg gcccagatgc ctcaggggct gataccaact     1380

gctcccccag aggatccagc tgtggatcta ctgaagaatt acatgaagat gggcagaaag     1440

cagagggaga acagagagag accttacaag gaggtgacag aggatttgct gcacctcaat     1500

tctctctttg gagaagacca gggtgccggc ggcaactacc ccgtgcagca aggcggcagc     1560

ccaaagaaga agcggaaggt ctctagacaa gagatcaaga gaatcaacaa gatcagaagg     1620

agactggtca aggacagcaa cacaaagaag gccggcaaga caggccccat gaaaaccctg     1680

ctcgtcagag tgatgacccc tgacctgaga gagcggctgg aaaacctgag aaagaagccc     1740

gagaacatcc ctcagcctat cagcaacacc agcagggcca acctgaacaa gctgctgacc     1800

gactacaccg agatgaagaa agccatcctg cacgtgtact gggaagagtt ccagaaagac     1860

cccgtgggcc tgatgagcag agttgctcag cctgccagca agaagatcga ccagaacaag     1920

ctgaagcccg agatggacga gaagggcaat ctgaccacag ccggctttgc ctgctctcag     1980

tgtggccagc ctctgttcgt gtacaagctg gaacaggtgt ccgagaaagg caaggcctac     2040

accaactact tcggcagatg taacgtggcc gagcacgaga agctgattct gctggcccag     2100

ctgaaacctg agaaggactc tgatgaggcc gtgacctaca gcctgggcaa gtttggacag     2160

agagccctgg acttctacag catccacgtg accaaagaaa gcacacaccc cgtgaagccc     2220

ctggctcaga tcgccggcaa tagatacgcc tctggacctg tgggcaaagc cctgtccgat     2280

gcctgcatgg gaacaatcgc cagcttcctg agcaagtacc aggacatcat catcgagcac     2340

cagaaggtgg tcaagggcaa ccagaagaga ctggaaagcc tgagggagct ggccggcaaa     2400

gagaacctgg aataccccag cgtgaccctg cctcctcagc ctcacacaaa agaaggcgtg     2460

gacgcctaca acgaagtgat cgccagagtg agaatgtggg tcaacctgaa cctgtggcag     2520

aagctgaaac tgtccaggga cgacgccaag cctctgctga gactgaaggg cttccctagc     2580

ttccctctgg tggaaagaca ggccaatgaa gtggattggt gggacatggt ctgcaacgtg     2640

aagaagctga tcaacgagaa gaaagaggat ggcaaggttt tctggcagaa cctggccggc     2700

tacaagagac aagaagccct gaggccttac ctgagcagcg aagaggaccg gaagaagggc     2760

aagaagttcg ccagatacca gctgggcgac ctgctgctgc acctggaaaa gaagcacggc     2820

gaggactggg gcaaagtgta cgatgaggcc tgggagagaa tcgacaagaa ggtggaaggc     2880

ctgagcaagc acattaagct ggaagaggaa agaaggagcg aggacgccca atctaaagcc     2940

gctctgaccg attggctgag agccaaggcc agctttgtga tcgagggcct gaaagaggcc     3000

gacaaggacg agttctgcag atgcgagctg aagctgcaga agtggtacgg cgatctgaga     3060

ggcaagccct tcgccattga ggccgagaac agcatcctgg acatcagcgg cttcagcaag     3120

cagtacaact gcgccttcat ttggcagaaa gacggcgtca agaaactgaa cctgtacctg     3180

atcatcaatt acttcaaagg cggcaagctg cggttcaaga agatcaaacc cgaggccttc     3240

gaggctaaca gattctacac cgtgatcaac aaaaagtccg gcgagatcgt gcccatggaa     3300

gtgaacttca acttcgacga ccccaacctg attatcctgc ctctggcctt cggcaagaga     3360

cagggcagag agttcatctg gaacgatctg ctgagcctgg aaaccggctc tctgaagctg     3420

gccaatggca gagtgatcga gaaaaccctg tacaacagga gaaccagaca ggacgagcct     3480

gctctgtttg tggccctgac cttcgagaga agagaggtgc tggacagcag caacatcaag     3540

cccatgaacc tgatcggcgt ggaccggggc gagaatatcc ctgctgtgat cgccctgaca     3600

gaccctgaag gatgcccact gagcagattc aaggactccc tgggcaaccc tacacacatc     3660

ctgagaatcg gcgagagcta caaagagaag cagaggacaa tccaggccaa gaaagaggtg     3720

gaacagagaa gagccggcgg atactctagg aagtacgcca gcaaggccaa gaatctggcc     3780

gacgacatgg tccgaaacac cgccagagat ctgctgtact acgccgtgac acaggacgcc     3840

atgctgatct tcgagaatct gagcagaggc ttcggccggc agggcaagag aacctttatg     3900

gccgagaggc agtacaccag aatggaagat tggctcacag ctaaactggc ctacgaggga     3960

ctgagcaaga cctacctgtc caaaacactg gcccagtata cctccaagac ctgcagcaat     4020

tgcggcttca ccatcaccag cgccgactac gacagagtgc tggaaaagct caagaaaacc     4080

gccaccggct ggatgaccac catcaacggc aaagagctga aggttgaggg ccagatcacc     4140

tactacaaca ggtacaagag gcagaacgtc gtgaaggatc tgagcgtgga actggacaga     4200

ctgagcgaag agagcgtgaa caacgacatc agcagctgga caaagggcag atcaggcgag     4260

gctctgagcc tgctgaagaa gaggtttagc cacagacctg tgcaagagaa gttcgtgtgc     4320

ctgaactgcg gcttcgagac acacgccgat gaacaggctg ccctgaacat tgccagaagc     4380

tggctgttcc tgagaagcca agagtacaag aagtaccaga ccaacaagac caccggcaac     4440

accgacaaga gggcctttgt ggaaacctgg cagagcttct acagaaaaaa gctgaaagaa     4500

gtctggaagc ccgccgtgac tagtccaaaa aagaagagaa aggtagccct cgagtaccca     4560

tatgatgtcc ctgactacgc ttga                                            4584


<210>  991
<211>  4389
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP142 plasmid sequence

<400>  991
atggccaagc agggctccaa ggagaagaag ggctaccccg agctgaagga agtgatcaag       60

gcaacctgca agatcagggt gggacctggc aaggagaccc tgacagaggg caactgtctg      120

tgggccctga agacaatcga cttcatcttt gaggatctga agaccgagcc atggaccatc      180

acaaagatgt atacagtgtg ggatcggctg aagggactga ccccagagga gacatccaag      240

agagagttcg cctctctgca ggccaccctg gcctgcatca tgtgctccca gatgggcatg      300

aagcctgaga cagtgcaggc cgccaagggc atcatctcta tgaaggaggg cctgcacgag      360

aataaggagg ccaagggcga gaaggtggag cagctgtacc ctaacctgga gaagcacagg      420

gaggtgtatc caatcgtgaa tctgcaggca ggaggccgca gctggaaggc agtggagtcc      480

gtggtgttcc agcagctgca gaccgtggcc atgcagcacg gcctggtgtc tgaggacttt      540

gagcggcagc tggcctacta tgccaccaca tggacaagca aggatatcct ggaggtgctg      600

gccatgatgc caggcaacag agcccagaag gagctgatcc agggcaagct gaatgaggag      660

gcagagcggt gggtgagaca gaacccacct ggacccaatg tgctgaccgt ggaccagatc      720

atgggcgtgg gccagacaaa ccagcaggcc agccaggcca atatggatca ggccaggcag      780

atctgcctgc agtgggtcat caccgccctg aggagcgtgc gccacatgtc ccacaggcct      840

ggaaacccaa tgctggtgaa gcagaagaat acagagtcct acgaggactt catcgccagg      900

ctgctggagg caatcgacgc agagcccgtg acagatccta tcaagaccta cctgaaggtg      960

accctgtctt atacaaacgc cagcaccgac tgccagaagc agatggatag gaccctggga     1020

acacgcgtgc agcaggcaac cgtggaggag aagatgcagg cctgtcggga tgtgggctct     1080

gagggcttta agatgcagct gctggcccag gccctgagac ctcagggcaa ggcaggacag     1140

aagggagtga accagaagtg ctacaattgt ggcaagccag gacacctggc aaggcagtgc     1200

agacagggaa tcatctgcca ccactgtggc aagaggggcc acatgcagaa ggactgtcgc     1260

cagaagaagc agcagggcaa caataggaga ggaccaaggg tggtgccatc tgccccacca     1320

atgctgggtg ccagggaggt gtatccaatc gtgaatggcg gcagcccaaa gaagaagcgg     1380

aaggtctcta gacaagagat caagagaatc aacaagatca gaaggagact ggtcaaggac     1440

agcaacacaa agaaggccgg caagacaggc cccatgaaaa ccctgctcgt cagagtgatg     1500

acccctgacc tgagagagcg gctggaaaac ctgagaaaga agcccgagaa catccctcag     1560

cctatcagca acaccagcag ggccaacctg aacaagctgc tgaccgacta caccgagatg     1620

aagaaagcca tcctgcacgt gtactgggaa gagttccaga aagaccccgt gggcctgatg     1680

agcagagttg ctcagcctgc cagcaagaag atcgaccaga acaagctgaa gcccgagatg     1740

gacgagaagg gcaatctgac cacagccggc tttgcctgct ctcagtgtgg ccagcctctg     1800

ttcgtgtaca agctggaaca ggtgtccgag aaaggcaagg cctacaccaa ctacttcggc     1860

agatgtaacg tggccgagca cgagaagctg attctgctgg cccagctgaa acctgagaag     1920

gactctgatg aggccgtgac ctacagcctg ggcaagtttg gacagagagc cctggacttc     1980

tacagcatcc acgtgaccaa agaaagcaca caccccgtga agcccctggc tcagatcgcc     2040

ggcaatagat acgcctctgg acctgtgggc aaagccctgt ccgatgcctg catgggaaca     2100

atcgccagct tcctgagcaa gtaccaggac atcatcatcg agcaccagaa ggtggtcaag     2160

ggcaaccaga agagactgga aagcctgagg gagctggccg gcaaagagaa cctggaatac     2220

cccagcgtga ccctgcctcc tcagcctcac acaaaagaag gcgtggacgc ctacaacgaa     2280

gtgatcgcca gagtgagaat gtgggtcaac ctgaacctgt ggcagaagct gaaactgtcc     2340

agggacgacg ccaagcctct gctgagactg aagggcttcc ctagcttccc tctggtggaa     2400

agacaggcca atgaagtgga ttggtgggac atggtctgca acgtgaagaa gctgatcaac     2460

gagaagaaag aggatggcaa ggttttctgg cagaacctgg ccggctacaa gagacaagaa     2520

gccctgaggc cttacctgag cagcgaagag gaccggaaga agggcaagaa gttcgccaga     2580

taccagctgg gcgacctgct gctgcacctg gaaaagaagc acggcgagga ctggggcaaa     2640

gtgtacgatg aggcctggga gagaatcgac aagaaggtgg aaggcctgag caagcacatt     2700

aagctggaag aggaaagaag gagcgaggac gcccaatcta aagccgctct gaccgattgg     2760

ctgagagcca aggccagctt tgtgatcgag ggcctgaaag aggccgacaa ggacgagttc     2820

tgcagatgcg agctgaagct gcagaagtgg tacggcgatc tgagaggcaa gcccttcgcc     2880

attgaggccg agaacagcat cctggacatc agcggcttca gcaagcagta caactgcgcc     2940

ttcatttggc agaaagacgg cgtcaagaaa ctgaacctgt acctgatcat caattacttc     3000

aaaggcggca agctgcggtt caagaagatc aaacccgagg ccttcgaggc taacagattc     3060

tacaccgtga tcaacaaaaa gtccggcgag atcgtgccca tggaagtgaa cttcaacttc     3120

gacgacccca acctgattat cctgcctctg gccttcggca agagacaggg cagagagttc     3180

atctggaacg atctgctgag cctggaaacc ggctctctga agctggccaa tggcagagtg     3240

atcgagaaaa ccctgtacaa caggagaacc agacaggacg agcctgctct gtttgtggcc     3300

ctgaccttcg agagaagaga ggtgctggac agcagcaaca tcaagcccat gaacctgatc     3360

ggcgtggacc ggggcgagaa tatccctgct gtgatcgccc tgacagaccc tgaaggatgc     3420

ccactgagca gattcaagga ctccctgggc aaccctacac acatcctgag aatcggcgag     3480

agctacaaag agaagcagag gacaatccag gccaagaaag aggtggaaca gagaagagcc     3540

ggcggatact ctaggaagta cgccagcaag gccaagaatc tggccgacga catggtccga     3600

aacaccgcca gagatctgct gtactacgcc gtgacacagg acgccatgct gatcttcgag     3660

aatctgagca gaggcttcgg ccggcagggc aagagaacct ttatggccga gaggcagtac     3720

accagaatgg aagattggct cacagctaaa ctggcctacg agggactgag caagacctac     3780

ctgtccaaaa cactggccca gtatacctcc aagacctgca gcaattgcgg cttcaccatc     3840

accagcgccg actacgacag agtgctggaa aagctcaaga aaaccgccac cggctggatg     3900

accaccatca acggcaaaga gctgaaggtt gagggccaga tcacctacta caacaggtac     3960

aagaggcaga acgtcgtgaa ggatctgagc gtggaactgg acagactgag cgaagagagc     4020

gtgaacaacg acatcagcag ctggacaaag ggcagatcag gcgaggctct gagcctgctg     4080

aagaagaggt ttagccacag acctgtgcaa gagaagttcg tgtgcctgaa ctgcggcttc     4140

gagacacacg ccgatgaaca ggctgccctg aacattgcca gaagctggct gttcctgaga     4200

agccaagagt acaagaagta ccagaccaac aagaccaccg gcaacaccga caagagggcc     4260

tttgtggaaa cctggcagag cttctacaga aaaaagctga aagaagtctg gaagcccgcc     4320

gtgactagtc caaaaaagaa gagaaaggta gccctcgagt acccatatga tgtccctgac     4380

tacgcttga                                                             4389


<210>  992
<211>  4809
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP143 plasmid sequence

<400>  992
atgggcaata gctcctctac cccccctcca agcgccctga agaactccga tctgttcaag       60

accatgctga ggacacagta cagcggctcc gtgaagacac ggagaatcaa ccaggatatc      120

aagaagcagt atccactgtg gccagaccag ggaacctgcg caacaaagca ctgggagcag      180

gccgtgctga tccccctgga ctctgtgagc gaggagaccg ccaaggtgct gaatttcctg      240

cgggtgaaga tccaggccag aaagggagag accgcaaggc agatgaccgc acacacaatc      300

aagaagctga tcgtgggcac aatcgataag aacaagcagc agaccgagat cctgcagaag      360

acagacgaga gcgatgagga gatggacacc acaaatacca tgctgtttat cgcccgcaac      420

aagagggaga ggatcgcaca gcagcagcag gcagatctgg cagcacagca gcaggtgctg      480

ctgctgcaga gggagcagca gagggagcag agagagaagg atatcaagaa gcgggacgag      540

aagaagaaga agctgctgcc cgacaccaca cagaaggtgg agcagaccga tatcggagag      600

gccagctcct ctgacgcctc cgcccagaag ccaatctcta ccgacaacaa tcccgatctg      660

aaggtggacg gcgtgctgac aagaagccag cacaccacag tgccttccaa catcaccatc      720

aagaaggatg gcacatccgt gcagtaccag caccccatca ggaactatcc taccggcgag      780

ggcaatctga cagcccaggt gcggaaccct tttagaccac tggagctgca gcagctgagg      840

aaggactgcc ccgccctgcc tgagggcatc ccacagctgg ccgagtggct gacccagaca      900

atggccatct acaattgtga cgaggccgat gtggagcagc tggccagagt gatcttccca      960

acccctgtga ggcagatcgc aggcgtgatc aacggacacg cagcagcaaa taccgcagcc     1020

aagatccaga actacgtgac agcatgcagg cagcactatc cagccgtgtg cgattggggc     1080

accatccagg cctttacata caagccccct cagaccgccc acgagtatgt gaagcacgcc     1140

gagatcatct tcaagaacaa tagcggactg gagtggcagc acgcaaccgt gccttttatc     1200

aatatggtgg tgcagggcct gccacccaag gtgacacggt ccctgatgtc tggcaaccca     1260

gattggagca ccaagacaat cccacagatc atccccctga tgcagcacta cctgaatctg     1320

cagtccagac aggacgccaa gatcaagcag acccctctgg tgctgcagct ggccatgcca     1380

gcccagacaa tgaacggcaa taagggctac gtgggctcct atcctaccaa cgagccatac     1440

tattctttcc agcagcagca gaggccagca cccagagccc ctccaggcaa cgtgccttcc     1500

aatacctgct tcttttgtaa gcagccagga cactggaagg cagactgccc taataagaca     1560

aggaacctgc gcaatatggg caacatggga aggggaggaa gaatgggagg accaccttac     1620

cggagccagc cttatccagc ctttatccag ccaccccaga atcaccagaa ccagtataat     1680

ggcaggatgg atcgctctca gctgcaggcc agcgcccagg agtggctgcc aggaacctac     1740

cctgcaggtg ccgcaaggca gatgaccgca cacacaggcg gcagcccaaa gaagaagcgg     1800

aaggtctcta gacaagagat caagagaatc aacaagatca gaaggagact ggtcaaggac     1860

agcaacacaa agaaggccgg caagacaggc cccatgaaaa ccctgctcgt cagagtgatg     1920

acccctgacc tgagagagcg gctggaaaac ctgagaaaga agcccgagaa catccctcag     1980

cctatcagca acaccagcag ggccaacctg aacaagctgc tgaccgacta caccgagatg     2040

aagaaagcca tcctgcacgt gtactgggaa gagttccaga aagaccccgt gggcctgatg     2100

agcagagttg ctcagcctgc cagcaagaag atcgaccaga acaagctgaa gcccgagatg     2160

gacgagaagg gcaatctgac cacagccggc tttgcctgct ctcagtgtgg ccagcctctg     2220

ttcgtgtaca agctggaaca ggtgtccgag aaaggcaagg cctacaccaa ctacttcggc     2280

agatgtaacg tggccgagca cgagaagctg attctgctgg cccagctgaa acctgagaag     2340

gactctgatg aggccgtgac ctacagcctg ggcaagtttg gacagagagc cctggacttc     2400

tacagcatcc acgtgaccaa agaaagcaca caccccgtga agcccctggc tcagatcgcc     2460

ggcaatagat acgcctctgg acctgtgggc aaagccctgt ccgatgcctg catgggaaca     2520

atcgccagct tcctgagcaa gtaccaggac atcatcatcg agcaccagaa ggtggtcaag     2580

ggcaaccaga agagactgga aagcctgagg gagctggccg gcaaagagaa cctggaatac     2640

cccagcgtga ccctgcctcc tcagcctcac acaaaagaag gcgtggacgc ctacaacgaa     2700

gtgatcgcca gagtgagaat gtgggtcaac ctgaacctgt ggcagaagct gaaactgtcc     2760

agggacgacg ccaagcctct gctgagactg aagggcttcc ctagcttccc tctggtggaa     2820

agacaggcca atgaagtgga ttggtgggac atggtctgca acgtgaagaa gctgatcaac     2880

gagaagaaag aggatggcaa ggttttctgg cagaacctgg ccggctacaa gagacaagaa     2940

gccctgaggc cttacctgag cagcgaagag gaccggaaga agggcaagaa gttcgccaga     3000

taccagctgg gcgacctgct gctgcacctg gaaaagaagc acggcgagga ctggggcaaa     3060

gtgtacgatg aggcctggga gagaatcgac aagaaggtgg aaggcctgag caagcacatt     3120

aagctggaag aggaaagaag gagcgaggac gcccaatcta aagccgctct gaccgattgg     3180

ctgagagcca aggccagctt tgtgatcgag ggcctgaaag aggccgacaa ggacgagttc     3240

tgcagatgcg agctgaagct gcagaagtgg tacggcgatc tgagaggcaa gcccttcgcc     3300

attgaggccg agaacagcat cctggacatc agcggcttca gcaagcagta caactgcgcc     3360

ttcatttggc agaaagacgg cgtcaagaaa ctgaacctgt acctgatcat caattacttc     3420

aaaggcggca agctgcggtt caagaagatc aaacccgagg ccttcgaggc taacagattc     3480

tacaccgtga tcaacaaaaa gtccggcgag atcgtgccca tggaagtgaa cttcaacttc     3540

gacgacccca acctgattat cctgcctctg gccttcggca agagacaggg cagagagttc     3600

atctggaacg atctgctgag cctggaaacc ggctctctga agctggccaa tggcagagtg     3660

atcgagaaaa ccctgtacaa caggagaacc agacaggacg agcctgctct gtttgtggcc     3720

ctgaccttcg agagaagaga ggtgctggac agcagcaaca tcaagcccat gaacctgatc     3780

ggcgtggacc ggggcgagaa tatccctgct gtgatcgccc tgacagaccc tgaaggatgc     3840

ccactgagca gattcaagga ctccctgggc aaccctacac acatcctgag aatcggcgag     3900

agctacaaag agaagcagag gacaatccag gccaagaaag aggtggaaca gagaagagcc     3960

ggcggatact ctaggaagta cgccagcaag gccaagaatc tggccgacga catggtccga     4020

aacaccgcca gagatctgct gtactacgcc gtgacacagg acgccatgct gatcttcgag     4080

aatctgagca gaggcttcgg ccggcagggc aagagaacct ttatggccga gaggcagtac     4140

accagaatgg aagattggct cacagctaaa ctggcctacg agggactgag caagacctac     4200

ctgtccaaaa cactggccca gtatacctcc aagacctgca gcaattgcgg cttcaccatc     4260

accagcgccg actacgacag agtgctggaa aagctcaaga aaaccgccac cggctggatg     4320

accaccatca acggcaaaga gctgaaggtt gagggccaga tcacctacta caacaggtac     4380

aagaggcaga acgtcgtgaa ggatctgagc gtggaactgg acagactgag cgaagagagc     4440

gtgaacaacg acatcagcag ctggacaaag ggcagatcag gcgaggctct gagcctgctg     4500

aagaagaggt ttagccacag acctgtgcaa gagaagttcg tgtgcctgaa ctgcggcttc     4560

gagacacacg ccgatgaaca ggctgccctg aacattgcca gaagctggct gttcctgaga     4620

agccaagagt acaagaagta ccagaccaac aagaccaccg gcaacaccga caagagggcc     4680

tttgtggaaa cctggcagag cttctacaga aaaaagctga aagaagtctg gaagcccgcc     4740

gtgactagtc caaaaaagaa gagaaaggta gccctcgagt acccatatga tgtccctgac     4800

tacgcttga                                                             4809


<210>  993
<211>  4698
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP78 plasmid sequence

<400>  993
atggccctga atgatttcga ccctatcgcc ctccagggct acctgccggc ccctagagtg       60

ctgcaacaca acgacatcat catctgcaga gctacttctg gcccctgggg catcggcgac      120

agatacaacc tgatcaggat ccacctgcaa gaccctgccg gacagcccct tccaatcccc      180

cagtgggagc ctatccctaa ccggaccgcc aacccccgga cacagcccta ccctgtggtg      240

tctgccccaa tggctaccct ggaaaacatc ctgaacaact ttcacatccc ccacggcgtg      300

tccagatacg gccccctgga aggcggagat taccagcctg gcgaacagta cagccaaggc      360

ttctgccctg tgacccaggc cgagattgcc ctgctgaacg gccagcacct ggaagaagag      420

atcacaatcc tgagagagat cacccacaga ctgatgcagg gcgtgcggcc tcctgccgtg      480

cctcagggcc ctgctcctcc tcctcctcca gctcagcctc ctgctcccct gcctgctcca      540

ccaattgggc ctccacctcc cgctgcccct gcccccgccc caggccccat gcctgtgccc      600

cagcatctgc ctattacaca tatcagagcc gtgatcggcg aaacccccgc caacatccgc      660

gaggtgccac tgtggctggc tagagccgtt cccgccctgc agggagtgta ccccgtccag      720

gacgccgtga tgagaagccg caccgtgaac gccctgaccg tgcggcaccc tggactggcc      780

ctggaacctc tggagtgcgg cagctggcaa gagtgtctgg ccgccctgtg gcagagaacc      840

ttcggcgcca ccgccctgca cgccctgggc gataccctgg gtcagatcgc aaacagcgac      900

ggcatcgtga tggctatcga gctgggcctg ctcttttccg atgataactg ggacctggtg      960

tggggaatct gtagaagatt cctgcccggc caggccgtct gcgtggccgt gcaggccaga     1020

ctggatcccc tgcccgacaa cgctacaaga atcgtgatga tcagccacat catccgggac     1080

gtgtacgcca tcctgggcct ggaccctctg ggcagaccca tgcagcagac actgcctaga     1140

cggaacaacc agcctcccag acagcagcca cagagacggc agcagcctag aagaaccggc     1200

aaccaggagg aaagaggcca gcggaaccgg ggccggcaga acgcccagac ccctcggcag     1260

gagggcaaca gactgcagaa cagccagctg cctggccctc gcgactgccc caacaatagc     1320

aaccagcctc ggtaccctct gcggccaaac ccccagcagc cccaaagata cggccaggag     1380

cagaatcgtg gcaacaatcc caacccttac agacaaccta cccctggcaa tggaaatcaa     1440

aacagaaact tcagccgggg gcctgcccca gtcaatgagc agagcagagg cagaggaaga     1500

tctagccagg gtacaaataa caccggctcc tctgctgtgc acagcgtgcg gctgaccagc     1560

gccgcccctc ctataccccc acaagatgcc ggcactccgc ccacttcaag tggaaatcaa     1620

gggcaatcat cttaaggtgc ctctgctgtg cacagcgtgc ggctgggcgg cagcccaaag     1680

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1740

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1800

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1860

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1920

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1980

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     2040

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     2100

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     2160

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     2220

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     2280

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2340

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2400

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2460

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     2520

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2580

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2640

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2700

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2760

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2820

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2880

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2940

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     3000

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     3060

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     3120

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     3180

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     3240

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3300

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3360

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3420

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3480

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3540

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3600

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3660

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3720

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3780

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3840

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3900

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3960

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     4020

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     4080

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     4140

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     4200

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     4260

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4320

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4380

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4440

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4500

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4560

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4620

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4680

gtccctgact acgcttga                                                   4698


<210>  994
<211>  4995
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP79 plasmid sequence

<400>  994
atgagccagc cctccgcttc tggcagcgcc ggcgccggag gcgcccctca gcaacctcct       60

cctccacctc cccagcccgg acctgccgcc cccgtgccta gagcccagat cggttatgga      120

gatctggacg tgcttctgct gcaacaggag taccacctca tcgatcctaa tctgcaagtg      180

caacacctgg acaccctgct ggtgagaatc acaggcggaa actggggccc tggcgataga      240

ttcgccagaa tcgaggtgct gctccgcgac acactgggcc ctctgcaaca gcctagatac      300

agatacgccg ccatgcagca ggccgacctg agaaacgaca tcatcctgca cctgaactac      360

caggatgcca tcatcatctt cgacatgatc atccccagcg agggcgtgca ccggcacggc      420

cctatgtttg acggcctgtg gatccacggc gacgactaca gcatgaactt ccagcctatc      480

acagcccacg agctgtacct gctgcctcag caggtgctga ccgaggaagt ggaactgctc      540

accgaggtgt gcaacagaat ggccgattgg atccggcggc acaggtgtgg cggaggaagc      600

ggctcctctc agccacctcc tcccccacct ccagccgtgc cagtgctgcc tagtgcccct      660

ccagccagca gcctgcccct gcccccacag ggctggggca tctctcctcc cgtggctacc      720

agcacccctg gcgctgccgg acattctagc agcgccggtc ctaacatcag cctgggcggc      780

acctacgtgc cccctcctgt ggctcctcca gcccctgtga tcggcggccc tggcggaccc      840

ggacagctgc ctgctatggt gcaggtgctg cccgctcaac ctgtcgtgat ccccattaac      900

gtgatcagat ctgtgtgcgg cgatacacct agcaaccctc aagacatccc tctgtggatg      960

ggcagaatca tccccgccat tgagggcgtc tttcctattg acaaccccaa tctgagaatg     1020

agagtggtga acgccctgct ggctctgcat cctggcctgg ctatcaccga actgaatgcc     1080

cagacatggg gccaggttct ggctgtgctg cacatgcggg ccctgggaca caccgccctg     1140

caccagctgc ctgccctgct ggaaacaatc gtgaagaccg acggcatcct gccagcttat     1200

aacatgggca tggaagttac acagcaggat ttcagctacg tgtggggcat cctgcggaca     1260

ctgttgcccg gccaagcctt cgtgctgagc atgcagaacg agctggaccg gctgcctgcc     1320

gcccagagac ctggaatgtt ccccggcctg ctgcagagaa ccctggatat cctgggcctg     1380

aacagcagag gacagaacat ccagaaaacc aacacccagc agcaggcccc aaagcggggc     1440

cagaagccta agcccagact gcccccagtg cacagacggc ctgcaccctt cacccctcct     1500

gccaccccca gccctcggca gcaggccagc gccagcccca gcagccaggg cgacaacaga     1560

agccctcagc ctcagggcag aggcacatac ggcccgagcc ggggaggcgg ctctggccct     1620

agatacaact tccgtcccag agtgcagcct cccgacagat acggcttcgg cagaggccag     1680

ggaggcagaa gcagcatcgg cgcccaggac aatcagcagc ccggacaagg cggacagcgg     1740

acccagcaga ccaaccagaa ccgcaaccag ggcaacgcca ccggcggtag aacccagcct     1800

cagaatagaa cagtgaacac cgtgcgggtg acccagacca atcctcaagg cggctcctcc     1860

gtgtccaacc cagctgtgac aacttctcag aatacaggaa caggaagtgc aactcagagc     1920

tcatcatctt aaggtgccag aacagtgaac accgtgcggg tgggcggcag cccaaagaag     1980

aagcggaagg tctctagaca agagatcaag agaatcaaca agatcagaag gagactggtc     2040

aaggacagca acacaaagaa ggccggcaag acaggcccca tgaaaaccct gctcgtcaga     2100

gtgatgaccc ctgacctgag agagcggctg gaaaacctga gaaagaagcc cgagaacatc     2160

cctcagccta tcagcaacac cagcagggcc aacctgaaca agctgctgac cgactacacc     2220

gagatgaaga aagccatcct gcacgtgtac tgggaagagt tccagaaaga ccccgtgggc     2280

ctgatgagca gagttgctca gcctgccagc aagaagatcg accagaacaa gctgaagccc     2340

gagatggacg agaagggcaa tctgaccaca gccggctttg cctgctctca gtgtggccag     2400

cctctgttcg tgtacaagct ggaacaggtg tccgagaaag gcaaggccta caccaactac     2460

ttcggcagat gtaacgtggc cgagcacgag aagctgattc tgctggccca gctgaaacct     2520

gagaaggact ctgatgaggc cgtgacctac agcctgggca agtttggaca gagagccctg     2580

gacttctaca gcatccacgt gaccaaagaa agcacacacc ccgtgaagcc cctggctcag     2640

atcgccggca atagatacgc ctctggacct gtgggcaaag ccctgtccga tgcctgcatg     2700

ggaacaatcg ccagcttcct gagcaagtac caggacatca tcatcgagca ccagaaggtg     2760

gtcaagggca accagaagag actggaaagc ctgagggagc tggccggcaa agagaacctg     2820

gaatacccca gcgtgaccct gcctcctcag cctcacacaa aagaaggcgt ggacgcctac     2880

aacgaagtga tcgccagagt gagaatgtgg gtcaacctga acctgtggca gaagctgaaa     2940

ctgtccaggg acgacgccaa gcctctgctg agactgaagg gcttccctag cttccctctg     3000

gtggaaagac aggccaatga agtggattgg tgggacatgg tctgcaacgt gaagaagctg     3060

atcaacgaga agaaagagga tggcaaggtt ttctggcaga acctggccgg ctacaagaga     3120

caagaagccc tgaggcctta cctgagcagc gaagaggacc ggaagaaggg caagaagttc     3180

gccagatacc agctgggcga cctgctgctg cacctggaaa agaagcacgg cgaggactgg     3240

ggcaaagtgt acgatgaggc ctgggagaga atcgacaaga aggtggaagg cctgagcaag     3300

cacattaagc tggaagagga aagaaggagc gaggacgccc aatctaaagc cgctctgacc     3360

gattggctga gagccaaggc cagctttgtg atcgagggcc tgaaagaggc cgacaaggac     3420

gagttctgca gatgcgagct gaagctgcag aagtggtacg gcgatctgag aggcaagccc     3480

ttcgccattg aggccgagaa cagcatcctg gacatcagcg gcttcagcaa gcagtacaac     3540

tgcgccttca tttggcagaa agacggcgtc aagaaactga acctgtacct gatcatcaat     3600

tacttcaaag gcggcaagct gcggttcaag aagatcaaac ccgaggcctt cgaggctaac     3660

agattctaca ccgtgatcaa caaaaagtcc ggcgagatcg tgcccatgga agtgaacttc     3720

aacttcgacg accccaacct gattatcctg cctctggcct tcggcaagag acagggcaga     3780

gagttcatct ggaacgatct gctgagcctg gaaaccggct ctctgaagct ggccaatggc     3840

agagtgatcg agaaaaccct gtacaacagg agaaccagac aggacgagcc tgctctgttt     3900

gtggccctga ccttcgagag aagagaggtg ctggacagca gcaacatcaa gcccatgaac     3960

ctgatcggcg tggaccgggg cgagaatatc cctgctgtga tcgccctgac agaccctgaa     4020

ggatgcccac tgagcagatt caaggactcc ctgggcaacc ctacacacat cctgagaatc     4080

ggcgagagct acaaagagaa gcagaggaca atccaggcca agaaagaggt ggaacagaga     4140

agagccggcg gatactctag gaagtacgcc agcaaggcca agaatctggc cgacgacatg     4200

gtccgaaaca ccgccagaga tctgctgtac tacgccgtga cacaggacgc catgctgatc     4260

ttcgagaatc tgagcagagg cttcggccgg cagggcaaga gaacctttat ggccgagagg     4320

cagtacacca gaatggaaga ttggctcaca gctaaactgg cctacgaggg actgagcaag     4380

acctacctgt ccaaaacact ggcccagtat acctccaaga cctgcagcaa ttgcggcttc     4440

accatcacca gcgccgacta cgacagagtg ctggaaaagc tcaagaaaac cgccaccggc     4500

tggatgacca ccatcaacgg caaagagctg aaggttgagg gccagatcac ctactacaac     4560

aggtacaaga ggcagaacgt cgtgaaggat ctgagcgtgg aactggacag actgagcgaa     4620

gagagcgtga acaacgacat cagcagctgg acaaagggca gatcaggcga ggctctgagc     4680

ctgctgaaga agaggtttag ccacagacct gtgcaagaga agttcgtgtg cctgaactgc     4740

ggcttcgaga cacacgccga tgaacaggct gccctgaaca ttgccagaag ctggctgttc     4800

ctgagaagcc aagagtacaa gaagtaccag accaacaaga ccaccggcaa caccgacaag     4860

agggcctttg tggaaacctg gcagagcttc tacagaaaaa agctgaaaga agtctggaag     4920

cccgccgtga ctagtccaaa aaagaagaga aaggtagccc tcgagtaccc atatgatgtc     4980

cctgactacg cttga                                                      4995


<210>  995
<211>  5010
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP80 plasmid sequence

<400>  995
atggcctctg gcagcaacgt ggaggaatac gagctggatg tggaagccct ggtggtcatc       60

ctgcgggaca gaaacatcgg aagaaatccc ctgcacggcg aaatcatcgg cctgagactg      120

accgagggct ggtggggcca gatcgagaga tttcagatgg tgcggctgat cctgcaggac      180

gacgacaacg agcccctgca gagaccccgc tacgaggtga tccccagagc cgtgaacccc      240

cacaccatgt tcatgatcag cggccccctg gctgaactgc agctggcctt ccaggacctg      300

gacctgcccg agggccctct gcggtttggc ccgctggcta acggccacta cgtgcagggg      360

gatccttaca gcagcagcta ccggcccgtg accatggccg aaacagccca gatgaccaga      420

gatgagctgg aagatatcct gaacacccaa agcgagatcg agatccagat gatcaacctg      480

ctggaacttt atgaggtgga aaccagagcc ctgagaagac agctggccga gagaagcagc      540

atcggccagg gaggagtgag ccccggcgct ccaaggccga gacctccagt tagcagcttc      600

agcggcctgc ctagcctgcc ttctatcccc ggcatccacc ccagagcccc ttcccctcct      660

cgcgctacaa gcacccctgg taacatcccc tggtccctgg gagatgacag cccacctagc      720

tcgtcttttc ctggccctag tcagcctaga gtgtctttcc accctggcaa tcctttcgtg      780

gaggacgagg gacatagacc tagatcccag agccgggaaa gacggagaaa caatcctcct      840

gcccctatcc ctagcgcccc tccaatgatc caatacgtgc ccgtgcctcc tccacctcct      900

gtcggaaccg tgatacctat ccaacacatc cggtccgtga ccggcgagcc tccaaagaac      960

ccccgagaaa tccccatctg gctgggccgg aatgcccctg ctatcgacgg cgttttcccc     1020

gtgacgaccc cagacctgcg gtgcagaatc atcaacgcca ttctgggagg caacctgggc     1080

ctgagcctga cacctgccga ctgtgtgacc tgggactctg ccgtgggcac cctgttcgtg     1140

cggacacacg gacagttccc tatgcaccag ctgggcacag tgatccaggg catcgtgaac     1200

caggagggcg tggctaccgc ttatacactg ggcatgatgc tgagcggcca gaattacccc     1260

ctcgtgagcg gcatcatcag aggctacctg cccggccagg ccgtggtgac cgcccttcag     1320

cagcgcctgg accaggaggt ggatgaccag gccagggctg aaaccttcat ccagcacctg     1380

aacgctgtgt acgagatcct gggcctcaac gccagaggac aatctatcag agccagcgtg     1440

acaccgcaac ctcggccaag ccggggccgc ggcagaggcc agtctacacc tagaccttcc     1500

cagggccctg tgagttcagg acggggcaga cagcggcctg ccagcggcca gtacgacaga     1560

ggcagcaaca accagaacca agaccagggt aacaccagcc agggcggcta caacctgaga     1620

ccaagaacct accagcctca gagatacggc ggcggaagag gtcggagatg gaacgagaac     1680

accaacagcc aggagagcag acccagcgat cagggctccc agacaccccg gcctaaccaa     1740

gctggcagcg gcgtcagagg caaccagagc cagaccccta gacccgccgc cggcagagga     1800

ggcagaggca atcagaatag aaaccagcgg tctagcggag ccggcgatag cagagccgtc     1860

aacacagtga cccagagtgc cacgtcctcc acagatgaat cctcttcagc tgttgcaacc     1920

gcttccagcg gagatcaaag gaactaaggt gccagagccg tcaacacagt gacccagggc     1980

ggcagcccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc     2040

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa     2100

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag     2160

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg     2220

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag     2280

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag     2340

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc     2400

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag     2460

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg     2520

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt     2580

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg     2640

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg     2700

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc     2760

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc     2820

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa     2880

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg     2940

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     3000

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     3060

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     3120

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     3180

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     3240

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     3300

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     3360

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     3420

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     3480

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     3540

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     3600

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     3660

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     3720

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     3780

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     3840

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     3900

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     3960

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     4020

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     4080

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     4140

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     4200

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     4260

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     4320

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     4380

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     4440

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     4500

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     4560

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     4620

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     4680

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     4740

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     4800

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     4860

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     4920

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt agccctcgag     4980

tacccatatg atgtccctga ctacgcttga                                      5010


<210>  996
<211>  4663
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP81 plasmid sequence

<400>  996
atggcccaga acgagacatt tgatcctgtg gccctgcagg gctactaccc tgctggcggc       60

atcctggccg acaatgacat tatcaacatc agattcacca gcggacagtg gggcatcggc      120

gatagatggc tgcaggtgcg gctgagactg gtggacccta atactggaca gcctctggct      180

cagcctgagt acgaggacac aggcctgcct gccgaaaaca ggggtatcgt ggtggccgtg      240

tcccacaacg ccgccagaaa tatcttcaac aacgtgcagc cagctggtgg ccccaacaga      300

cacggccctc tgcacgacgg ccaatttcaa gtgggcgacg atcccagcga gcacttcgtg      360

cctattgagg aaaacctgat cccccaggag atcgtgaacc tgggagcagc tagaagagaa      420

gtgcggctgc tgagagaaat gtgcgtgcgg ctgctgcacg tgagaagaca gatgatgggc      480

atgggcatgc ctggcgctat ccagcctcaa ccgccagtgg gccccctgcc cgcccctgcc      540

cagcccccta tccctggccc acctgtgcct ccccccgtgc ctccccccgc ccctccagcc      600

cctgtcaacc cccctgtccc tccagtgcag cctatccacc acctgcctat tacccacatc      660

cgggccgtga tcggcgagac acctgcccag atcagagatg tgcccctgtg gctggcccag      720

tccatccctg ccctgaccgg cgtttatcct gccatggacg ccggaacact gacaagactg      780

gtgaacgcga tcaccgccag acaccccgga ctcgctcttg gcatgaacga ggccggctcc      840

tggcacgagg ccgttcatct gatctggcag aggaccttcg gcgctacagc cctccatgcc      900

ttgtctgatg tgctgaaggg catcgcccag cggaacggcg tggtgatggc cctggaaatg      960

ggcctgatgt tcaccaacga cgactgggac ctgacctggt ctgtgatccg gagatgtctg     1020

cctggacaag ccagcgttgt gaccatccag gcccggctgg atgccctgcc aaacaaccag     1080

gccaggatca tccaggccgg ctttatcatc agagaggtgt acgaggtgct gggcctggac     1140

ccactgggcc ggccactgaa cttccctgga ggcctgaccc agcgagacac cgccgtgccc     1200

gtgaccagag gccggggccg cggaagaacc ggccctagaa gaggccctgt gctgcctgtc     1260

agcagcaacc agcgccggca agaaaccgca ggcggcaacc agcctcagac ccaaccccag     1320

cagcagaaca cattcagcaa tcagacaaat cagagaggaa accagcggca gtggcaaaat     1380

agaggaaccg acagccagag acggtacttc ttcagaccca gaccaagcca gcctcagcgg     1440

tacggcagca accagggccc tgacaaccct aatccctaca gaggaagaga tagcaccaat     1500

caaagcggcc aggagcggca gctgcctcag cagcaacagg gctctagaag gggccctggc     1560

agaaacacaa acagcggcaa caacaccgtg cacaccgtgc ggcaagtgga atcttctcag     1620

ctacaacaaa ggcggcagcc caaagaagaa gcggaaggtc tctagacaag agatcaagag     1680

aatcaacaag atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac     1740

aggccccatg aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga     1800

aaacctgaga aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa     1860

cctgaacaag ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg     1920

ggaagagttc cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa     1980

gaagatcgac cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc     2040

cggctttgcc tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc     2100

cgagaaaggc aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa     2160

gctgattctg ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag     2220

cctgggcaag tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag     2280

cacacacccc gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt     2340

gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca     2400

ggacatcatc atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct     2460

gagggagctg gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc     2520

tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt     2580

caacctgaac ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag     2640

actgaagggc ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg     2700

ggacatggtc tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt     2760

ctggcagaac ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga     2820

agaggaccgg aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca     2880

cctggaaaag aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat     2940

cgacaagaag gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga     3000

ggacgcccaa tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat     3060

cgagggcctg aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa     3120

gtggtacggc gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga     3180

catcagcggc ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa     3240

gaaactgaac ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa     3300

gatcaaaccc gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg     3360

cgagatcgtg cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc     3420

tctggccttc ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga     3480

aaccggctct ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag     3540

aaccagacag gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct     3600

ggacagcagc aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc     3660

tgctgtgatc gccctgacag accctgaagg atgcccactg agcagattca aggactccct     3720

gggcaaccct acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat     3780

ccaggccaag aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag     3840

caaggccaag aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta     3900

cgccgtgaca caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca     3960

gggcaagaga acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc     4020

taaactggcc tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac     4080

ctccaagacc tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct     4140

ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa     4200

ggttgagggc cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct     4260

gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac     4320

aaagggcaga tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt     4380

gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc     4440

cctgaacatt gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac     4500

caacaagacc accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta     4560

cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa     4620

ggtagccctc gagtacccat atgatgtccc tgactacgct tga                       4663


<210>  997
<211>  4528
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP82 plasmid sequence

<400>  997
atggcccggg aactgaaccc cctgcagctg caacagctgt acatcaacaa tggcctgcag       60

cccaatcccg gccacggaga tatcatcgca gttagattca caggcggccc ttggggcccc      120

ggagatagat gggccagagt gaccatccgg ctgcaggaca acaccggcca gcctctgcaa      180

gtgcccggat acgacctgga gcctggcatc atcaatctgc gggaagatat cctgatcgcc      240

ggcccataca acctcatcag aacagctttt ctggacctgg aacctgccag aggaccagag      300

cggcacggcc cgttcggcga cggcagactg cagcctggcg atggactgag cgagggattt      360

cagcctatca ccgacgagga aatccaggct gaagtgggca ccatcggcgc cgcccgtaac      420

gagatccggc tgctgagaga agccttgcag agactccagg ctggcggtgt tggacggcct      480

atccctgggg ccgtgctgca gcctcaacct gtgatcggac ctgtgatccc catcaaccac      540

ctgagaagcg tgattggcaa cacacctcct aaccccagag atgtggccct gtggttgggc      600

agatctacag ccgctatcga gggcgtgttc cccatcgtgg accaggtgac ccggatgaga      660

gtggtgaacg ccctggtcgc ctctcatcct ggcctgaccc tgacagagaa cgaggccggc      720

agctggaacg ccgccatcag cgccctgtgg cggaaggccc acggcgctgc tgctcagcac      780

gagctggccg gagtgctgag cgacatcaac aagaaggaag gcatccagac agccttcaac      840

ctgggcatgc agttcaccga tggcaattgg tccctggtgt ggggaatcat caggaccctg      900

ctgcccggcc aggccctggt cacaaacgcc cagagccagt tcgacctgat gggcgacgac      960

attcagcggg ccgagaactt ccccagagtg attaacaacc tgtacaccat gctgggcctg     1020

aacatccacg gccagagcat cagacctaga gtgcagaccc agcctctgca gaccagacct     1080

cggaaccctg gcagaagcca gcagggtcag ctgaatcagc ctcggcctca gaacagagcc     1140

aaccagtcct acagaccccc tcggcagcag caacaacaca gcgacgtgcc tgagcagagg     1200

gaccagagag gcccatctca accgcctaga ggctctggcg gaggctataa cttcagaaga     1260

aatccccagc agcctcagcg gtacggccaa ggcccccccg gcccaaaccc ttacagacgg     1320

ttcggcgacg gcggcaatcc ccagcagcaa ggcccgcctc caaatagagg ccctgatcag     1380

ggacctagac caggcggcaa ccctcgcggc ggcggcaggg ggcagggccc ccggaacggc     1440

ggaggcagcg ccgccgccgt gcacaccgtg aaagccagcg aaaacgaaac taaaaggcgg     1500

cagcccaaag aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag     1560

aaggagactg gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac     1620

cctgctcgtc agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa     1680

gcccgagaac atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct     1740

gaccgactac accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa     1800

agaccccgtg ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa     1860

caagctgaag cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc     1920

tcagtgtggc cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc     1980

ctacaccaac tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc     2040

ccagctgaaa cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg     2100

acagagagcc ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa     2160

gcccctggct cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc     2220

cgatgcctgc atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga     2280

gcaccagaag gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg     2340

caaagagaac ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg     2400

cgtggacgcc tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg     2460

gcagaagctg aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc     2520

tagcttccct ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa     2580

cgtgaagaag ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc     2640

cggctacaag agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa     2700

gggcaagaag ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca     2760

cggcgaggac tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga     2820

aggcctgagc aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa     2880

agccgctctg accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga     2940

ggccgacaag gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct     3000

gagaggcaag cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag     3060

caagcagtac aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta     3120

cctgatcatc aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc     3180

cttcgaggct aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat     3240

ggaagtgaac ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa     3300

gagacagggc agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa     3360

gctggccaat ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga     3420

gcctgctctg tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat     3480

caagcccatg aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct     3540

gacagaccct gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca     3600

catcctgaga atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga     3660

ggtggaacag agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct     3720

ggccgacgac atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga     3780

cgccatgctg atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt     3840

tatggccgag aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga     3900

gggactgagc aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag     3960

caattgcggc ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa     4020

aaccgccacc ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat     4080

cacctactac aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga     4140

cagactgagc gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg     4200

cgaggctctg agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt     4260

gtgcctgaac tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag     4320

aagctggctg ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg     4380

caacaccgac aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa     4440

agaagtctgg aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta     4500

cccatatgat gtccctgact acgcttga                                        4528


<210>  998
<211>  4977
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP83 plasmid sequence

<400>  998
atggccgctg tggaaggcga tctggacgtg caagccctga ccgatctgtt caacaacctg       60

ggcatcaacc gggacccccg gcaccgggaa gtgatcgccc tgcggatgac aggcggctgg      120

tggggccctg ccaccagata caacctgatc accgtgctgc tgcaggatga tcagggtcag      180

cctcttcagc agccccggtg gcgggccgag ggccgggccg ccaaccccgc tgtgatgctg      240

accctggaag ccccatggca ggacctgcgg atggcctttg acaacgtcga cctggccgac      300

gacacactgc ggtttggccc tctggctaac ggcaattaca tccccggcga cgagtacagc      360

ctggagttca tccctcccgc catgcaagag atcgcccaaa tgcagagaga tgagctggaa      420

aacgtgctgg acattgtggg ccagatcaca atgcagatga gcgacctgat cggaatgcag      480

gacgcccaga tccggggcct ggagggccaa atcagaggcc tgagaggcaa tctgcccgtg      540

gccggaacac caccacctcc tcctccaagc ctggacctgc agcctgccgc cgccagcagc      600

ccttacgtgg cccctgcgtc tagcgctcct gccgcacccg tggcctctgc tgatctgggc      660

tggttcgccg ggggaccttc cccaggctct gtggaccctc ggctggcccg ggtcgcctac      720

aaccccttcc tgcccggacc tagcgacggc agcggcgtgg ccccggtgca gccctccgcc      780

cctcctgccg ccagccctct gctgcccctg ccacctgctc agcctgtgca gccagtgatc      840

cagtacgtgc accctcctcc tatgaaccct gcccagcaga ttattcctat ccagcacatc      900

agagccgtga ccggcaacgc ccccaccaac cctagagaga tccctatgtg gatcggcaga      960

aacgccagcg ccatcgaggg cgtgttcccc atgaccaccc ctgatctgag gtgtcgggtg     1020

atcaacgccc tgctcggcgg caacctgggc ctgaacctgg aaccacagca ctgcgtgacc     1080

tgggccagcg caatcgccac cctgtacgtt agaacccacg gcagctaccc catccaccag     1140

ctggctgaag tgctgagagg cgtggctaat agcgagggag ttgctgccgc ttatcagctg     1200

ggcatgatgc tgacaaaccg ggattacaac ctgatctggg ggatcatccg ccctctgctg     1260

cccggccagg ccgtcgtgac cgccatgcag catagactgg atcaggagat caacgacgcc     1320

gccagagtgg cctctttcat caatcacctg aacggcgtgt acgagctgct gggcttgaac     1380

gccagaggcc agagcctgag aatccctgcc tctggcggac agaccacggc cggaaccagc     1440

gccggcagag gcacaagagg aagacgcagc cagcaaggca cacctggcag acagagcagc     1500

ggccagagcc agcagcaggg aagaagaagc agccagggcc agagcagaca gtcagactcc     1560

agcgaccaga acgtgcagag acaatcccag ggcggcaacg gacggggagg ctataatctg     1620

agacccagga cctaccagcc ccagagatac ggcggaggca gaggcagaag gtggaacgac     1680

cagcctgcca gatcagacaa ccagcagcgg tcccaatctc aacagcctca gtccgaggct     1740

agaggcgagc agagcagaac cagcggagcc ggcagaggac agggcggccg ggggaatcaa     1800

aacagaaacc agagaagcgc cggtggcaat gccgacagaa cagtgaacac cgtgacaacc     1860

gccagcgctt ctacaagcgc ctcaggtcaa gatggatcct ctccagctcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaggcggc agcccaaaga agaagcggaa ggtctctaga     1980

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     2040

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     2100

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     2160

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     2220

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     2280

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     2340

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     2400

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     2460

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     2520

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     2580

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     2640

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     2700

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     2760

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     2820

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     2880

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     2940

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     3000

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     3060

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     3120

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     3180

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     3240

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     3300

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     3360

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     3420

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     3480

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     3540

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     3600

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     3660

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     3720

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     3780

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     3840

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     3900

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     3960

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     4020

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     4080

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     4140

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     4200

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     4260

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     4320

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     4380

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     4440

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     4500

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     4560

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     4620

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     4680

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     4740

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     4800

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     4860

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     4920

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        4977


<210>  999
<211>  4977
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP84 plasmid sequence

<400>  999
atggccgcca tcgagggcga tctggacgtg caggccctgg ctaacctgtt caacgacctg       60

ggcatcaaca gaaaccccag acacagagag gtgattgccc tgagaatgac cggcggctgg      120

tggggccccg ctaccagata taatctggtg agcctgctgc tgcaggacga ccagggccag      180

cctctgccac agcccagatg gcgggctgaa ggcagagccg caaaccccgc cgtgatgttc      240

accctggaag ccccctggca ggatctgaga ctggcctttg acaatatcga cgtgggcgag      300

ggcacactga gattcggccc acttgctaac ggcaactaca tccccggcga cgagttcagc      360

ctggagttcc tgcctcctgc catgcaggag atcacacaga tgcagagaga tgagctggag      420

gaagtgctgg atgtggtggg ccagatcaca atgcagatga acgacctgat cggcatgcag      480

gacgcccaga tccggggact ggaaggacaa ctgagaggac tgagaggcaa tctgccagtg      540

gccggcacac ctccacctcc tccacccagc ctggacctgc agcctgctgc cgccagcagc      600

ccctacgtgg cccctgcacc ttccgctcct gctgcctctg ccgccgcagc cgacctggga      660

tggttcgccg gaggccctgg ccctggatct ctggaccccc gcctcgcccg ggtggcctac      720

aacccctttc tgcctggccc tagcgacggc agcggtgccg ctcccgccca gcctagcgct      780

cctccggtgg cctctcctct gccttctctg ctgcctgccc agcccatgca acctgtgatc      840

cagtacgtgc accccccacc tatcaatcct gctcaacagg tgatccctat tcagcatatc      900

agagccgtga ccggcaacgc ccctagcaac ccaagagaaa tccctatgtg gatcggaaga      960

aacgccagcg ccatcgaggg cgtgttcccc atccctacat ctgacatccg ttctagagtg     1020

atcaacgccc tgctgggtag acagctgggc ctgaacctgg atcctcagca ctgcatcacc     1080

tgggccagcg caatcgccac tctgtacgtg cgcacccacg gcagctaccc tctgcaccag     1140

ctggccgagg ttctgcggag agtctccaac agcgaaggcg cggccgccgc ctggcagctg     1200

ggcatgatgc tgaccaacca ggactacaac ctcgtgtggg gaatggtcag acccctgctg     1260

cccggccagg ctgtggtcac cgccatgcag caccggctgg atcaggaggt ttctgatgcc     1320

gccagaatcg tgtccttcgt gaaccacctg aacgccgtgt acgagctgct gggcctgaat     1380

gccagaggcc agaacctcag ggtctccacc ggcggccaga ccaccgctag aacaagcgcc     1440

ggcagaggcg ccagaggcag acggtcccag caggggaccc ctggcaggca gtctagcgga     1500

caggcccctc ctcaaggccg gagaagcagc cagggccagc agcctaggca gtctgagagc     1560

ggcgaccaga acaaccagcg gcagctccag ggaggaaaca accggggcgg ctataacctg     1620

cggcctcgga cataccagcc tcagcggtac gggggaggcc ggggccggag atggaacgat     1680

cagaccgcca gagccgataa ccagcagcgg agccaatccc aacaacctca gagcgaggcc     1740

cggggcgagc agagcagaac cagcggcgcc ggcagagaac agggcggcag aggcaatcaa     1800

aatcggaatc aaagatctgc cggagaaaac accgacagat ccgtgaacac cgtgacagcc     1860

accagcgcca gcatcagcgc ctcaggtcaa aatggatcct ctacaactcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaggcggc agcccaaaga agaagcggaa ggtctctaga     1980

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     2040

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     2100

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     2160

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     2220

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     2280

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     2340

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     2400

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     2460

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     2520

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     2580

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     2640

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     2700

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     2760

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     2820

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     2880

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     2940

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     3000

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     3060

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     3120

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     3180

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     3240

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     3300

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     3360

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     3420

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     3480

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     3540

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     3600

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     3660

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     3720

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     3780

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     3840

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     3900

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     3960

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     4020

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     4080

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     4140

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     4200

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     4260

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     4320

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     4380

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     4440

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     4500

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     4560

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     4620

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     4680

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     4740

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     4800

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     4860

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     4920

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        4977


<210>  1000
<211>  4805
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP88 plasmid sequence

<400>  1000
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa      780

atctataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc      900

tataaaactc taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga     1020

gcgacactag aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca     1080

agagttttgg ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa     1140

ggcaatttta ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac     1200

atagccaaaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

cacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac     1440

aaggaactgt atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa     1500

taaagatagg ggggcaatta aaggaagctc tattagatac aggagcagat gatacagtat     1560

tagaagaaat gaatttgcca ggaagatgga aaccaaaaat gataggggga attggaggtt     1620

ttatcaaagt aagacagtat gatcagatac tcatagaaat ctgcggacat aaagctatag     1680

gtacagtatt agtaggacct acacctgtca acataattgg aagaaatctg ttgactcaga     1740

ttggctgcac tttaaatttt cccattagtc ctattgagac tgtaccaaag aagaagcgga     1800

aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg gtcaaggaca     1860

gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc agagtgatga     1920

cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac atccctcagc     1980

ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac accgagatga     2040

agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg ggcctgatga     2100

gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag cccgagatgg     2160

acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc cagcctctgt     2220

tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac tacttcggca     2280

gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa cctgagaagg     2340

actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc ctggacttct     2400

acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct cagatcgccg     2460

gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc atgggaacaa     2520

tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag gtggtcaagg     2580

gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac ctggaatacc     2640

ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc tacaacgaag     2700

tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg aaactgtcca     2760

gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct ctggtggaaa     2820

gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag ctgatcaacg     2880

agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag agacaagaag     2940

ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag ttcgccagat     3000

accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac tggggcaaag     3060

tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc aagcacatta     3120

agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg accgattggc     3180

tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag gacgagttct     3240

gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag cccttcgcca     3300

ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac aactgcgcct     3360

tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc aattacttca     3420

aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct aacagattct     3480

acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac ttcaacttcg     3540

acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc agagagttca     3600

tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat ggcagagtga     3660

tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg tttgtggccc     3720

tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg aacctgatcg     3780

gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct gaaggatgcc     3840

cactgagcag attcaaggac tccctgggca accctacaca catcctgaga atcggcgaga     3900

gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag agaagagccg     3960

gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac atggtccgaa     4020

acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg atcttcgaga     4080

atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag aggcagtaca     4140

ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc aagacctacc     4200

tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc ttcaccatca     4260

ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc ggctggatga     4320

ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac aacaggtaca     4380

agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc gaagagagcg     4440

tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg agcctgctga     4500

agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac tgcggcttcg     4560

agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg ttcctgagaa     4620

gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac aagagggcct     4680

ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg aagcccgccg     4740

tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat gtccctgact     4800

acgct                                                                 4805


<210>  1001
<211>  2413
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pStx42.174.12.7 plasmid sequence

<400>  1001
gctagctagg tctagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt       60

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa      120

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt      180

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa      240

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac      300

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt      360

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt      420

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat      480

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac      540

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg      600

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc      660

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa      720

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag      780

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct      840

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat      900

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa      960

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     1020

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     1080

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     1140

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     1200

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     1260

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     1320

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     1380

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     1440

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     1500

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     1560

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     1620

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     1680

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     1740

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     1800

ccgacaggcc cgaaggaata gaagaagaag gtggagagag agacagagac agatccattc     1860

gattagtgaa cggatctcga cggtatcgcc tttaaaagaa aaggggggat tggggggtac     1920

agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa agaactacaa     1980

aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag agatccagtt     2040

tgagggccta tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga     2100

gataattgga attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag     2160

aaagtaataa tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca     2220

tatgcttacc gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg     2280

acgaaacacc actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc     2340

gtagtgggta aagctccctc ttcggaggga gcatcaaagc tgcattctag ttgtggtttt     2400

tttttttgaa ttc                                                        2413


<210>  1002
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 plasmid sequence

<400>  1002
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  1003
<211>  4698
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP78 plasmid sequence

<400>  1003
atggccctga atgatttcga ccctatcgcc ctccagggct acctgccggc ccctagagtg       60

ctgcaacaca acgacatcat catctgcaga gctacttctg gcccctgggg catcggcgac      120

agatacaacc tgatcaggat ccacctgcaa gaccctgccg gacagcccct tccaatcccc      180

cagtgggagc ctatccctaa ccggaccgcc aacccccgga cacagcccta ccctgtggtg      240

tctgccccaa tggctaccct ggaaaacatc ctgaacaact ttcacatccc ccacggcgtg      300

tccagatacg gccccctgga aggcggagat taccagcctg gcgaacagta cagccaaggc      360

ttctgccctg tgacccaggc cgagattgcc ctgctgaacg gccagcacct ggaagaagag      420

atcacaatcc tgagagagat cacccacaga ctgatgcagg gcgtgcggcc tcctgccgtg      480

cctcagggcc ctgctcctcc tcctcctcca gctcagcctc ctgctcccct gcctgctcca      540

ccaattgggc ctccacctcc cgctgcccct gcccccgccc caggccccat gcctgtgccc      600

cagcatctgc ctattacaca tatcagagcc gtgatcggcg aaacccccgc caacatccgc      660

gaggtgccac tgtggctggc tagagccgtt cccgccctgc agggagtgta ccccgtccag      720

gacgccgtga tgagaagccg caccgtgaac gccctgaccg tgcggcaccc tggactggcc      780

ctggaacctc tggagtgcgg cagctggcaa gagtgtctgg ccgccctgtg gcagagaacc      840

ttcggcgcca ccgccctgca cgccctgggc gataccctgg gtcagatcgc aaacagcgac      900

ggcatcgtga tggctatcga gctgggcctg ctcttttccg atgataactg ggacctggtg      960

tggggaatct gtagaagatt cctgcccggc caggccgtct gcgtggccgt gcaggccaga     1020

ctggatcccc tgcccgacaa cgctacaaga atcgtgatga tcagccacat catccgggac     1080

gtgtacgcca tcctgggcct ggaccctctg ggcagaccca tgcagcagac actgcctaga     1140

cggaacaacc agcctcccag acagcagcca cagagacggc agcagcctag aagaaccggc     1200

aaccaggagg aaagaggcca gcggaaccgg ggccggcaga acgcccagac ccctcggcag     1260

gagggcaaca gactgcagaa cagccagctg cctggccctc gcgactgccc caacaatagc     1320

aaccagcctc ggtaccctct gcggccaaac ccccagcagc cccaaagata cggccaggag     1380

cagaatcgtg gcaacaatcc caacccttac agacaaccta cccctggcaa tggaaatcaa     1440

aacagaaact tcagccgggg gcctgcccca gtcaatgagc agagcagagg cagaggaaga     1500

tctagccagg gtacaaataa caccggctcc tctgctgtgc acagcgtgcg gctgaccagc     1560

gccgcccctc ctataccccc acaagatgcc ggcactccgc ccacttcaag tggaaatcaa     1620

gggcaatcat cttaaggtgc ctctgctgtg cacagcgtgc ggctgggcgg cagcccaaag     1680

aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag aaggagactg     1740

gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc     1800

agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac     1860

atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac     1920

accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg     1980

ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa caagctgaag     2040

cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc tcagtgtggc     2100

cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc ctacaccaac     2160

tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc ccagctgaaa     2220

cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg acagagagcc     2280

ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa gcccctggct     2340

cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc cgatgcctgc     2400

atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga gcaccagaag     2460

gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg caaagagaac     2520

ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg cgtggacgcc     2580

tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg gcagaagctg     2640

aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc tagcttccct     2700

ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa cgtgaagaag     2760

ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc cggctacaag     2820

agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa gggcaagaag     2880

ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca cggcgaggac     2940

tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga aggcctgagc     3000

aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa agccgctctg     3060

accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga ggccgacaag     3120

gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct gagaggcaag     3180

cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag caagcagtac     3240

aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta cctgatcatc     3300

aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc cttcgaggct     3360

aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat ggaagtgaac     3420

ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa gagacagggc     3480

agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa gctggccaat     3540

ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga gcctgctctg     3600

tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat caagcccatg     3660

aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct gacagaccct     3720

gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca catcctgaga     3780

atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga ggtggaacag     3840

agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct ggccgacgac     3900

atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga cgccatgctg     3960

atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt tatggccgag     4020

aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga gggactgagc     4080

aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc     4140

ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc     4200

ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac     4260

aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc     4320

gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg     4380

agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac     4440

tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg     4500

ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac     4560

aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg     4620

aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta cccatatgat     4680

gtccctgact acgcttga                                                   4698


<210>  1004
<211>  4995
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP79 plasmid sequence

<400>  1004
atgagccagc cctccgcttc tggcagcgcc ggcgccggag gcgcccctca gcaacctcct       60

cctccacctc cccagcccgg acctgccgcc cccgtgccta gagcccagat cggttatgga      120

gatctggacg tgcttctgct gcaacaggag taccacctca tcgatcctaa tctgcaagtg      180

caacacctgg acaccctgct ggtgagaatc acaggcggaa actggggccc tggcgataga      240

ttcgccagaa tcgaggtgct gctccgcgac acactgggcc ctctgcaaca gcctagatac      300

agatacgccg ccatgcagca ggccgacctg agaaacgaca tcatcctgca cctgaactac      360

caggatgcca tcatcatctt cgacatgatc atccccagcg agggcgtgca ccggcacggc      420

cctatgtttg acggcctgtg gatccacggc gacgactaca gcatgaactt ccagcctatc      480

acagcccacg agctgtacct gctgcctcag caggtgctga ccgaggaagt ggaactgctc      540

accgaggtgt gcaacagaat ggccgattgg atccggcggc acaggtgtgg cggaggaagc      600

ggctcctctc agccacctcc tcccccacct ccagccgtgc cagtgctgcc tagtgcccct      660

ccagccagca gcctgcccct gcccccacag ggctggggca tctctcctcc cgtggctacc      720

agcacccctg gcgctgccgg acattctagc agcgccggtc ctaacatcag cctgggcggc      780

acctacgtgc cccctcctgt ggctcctcca gcccctgtga tcggcggccc tggcggaccc      840

ggacagctgc ctgctatggt gcaggtgctg cccgctcaac ctgtcgtgat ccccattaac      900

gtgatcagat ctgtgtgcgg cgatacacct agcaaccctc aagacatccc tctgtggatg      960

ggcagaatca tccccgccat tgagggcgtc tttcctattg acaaccccaa tctgagaatg     1020

agagtggtga acgccctgct ggctctgcat cctggcctgg ctatcaccga actgaatgcc     1080

cagacatggg gccaggttct ggctgtgctg cacatgcggg ccctgggaca caccgccctg     1140

caccagctgc ctgccctgct ggaaacaatc gtgaagaccg acggcatcct gccagcttat     1200

aacatgggca tggaagttac acagcaggat ttcagctacg tgtggggcat cctgcggaca     1260

ctgttgcccg gccaagcctt cgtgctgagc atgcagaacg agctggaccg gctgcctgcc     1320

gcccagagac ctggaatgtt ccccggcctg ctgcagagaa ccctggatat cctgggcctg     1380

aacagcagag gacagaacat ccagaaaacc aacacccagc agcaggcccc aaagcggggc     1440

cagaagccta agcccagact gcccccagtg cacagacggc ctgcaccctt cacccctcct     1500

gccaccccca gccctcggca gcaggccagc gccagcccca gcagccaggg cgacaacaga     1560

agccctcagc ctcagggcag aggcacatac ggcccgagcc ggggaggcgg ctctggccct     1620

agatacaact tccgtcccag agtgcagcct cccgacagat acggcttcgg cagaggccag     1680

ggaggcagaa gcagcatcgg cgcccaggac aatcagcagc ccggacaagg cggacagcgg     1740

acccagcaga ccaaccagaa ccgcaaccag ggcaacgcca ccggcggtag aacccagcct     1800

cagaatagaa cagtgaacac cgtgcgggtg acccagacca atcctcaagg cggctcctcc     1860

gtgtccaacc cagctgtgac aacttctcag aatacaggaa caggaagtgc aactcagagc     1920

tcatcatctt aaggtgccag aacagtgaac accgtgcggg tgggcggcag cccaaagaag     1980

aagcggaagg tctctagaca agagatcaag agaatcaaca agatcagaag gagactggtc     2040

aaggacagca acacaaagaa ggccggcaag acaggcccca tgaaaaccct gctcgtcaga     2100

gtgatgaccc ctgacctgag agagcggctg gaaaacctga gaaagaagcc cgagaacatc     2160

cctcagccta tcagcaacac cagcagggcc aacctgaaca agctgctgac cgactacacc     2220

gagatgaaga aagccatcct gcacgtgtac tgggaagagt tccagaaaga ccccgtgggc     2280

ctgatgagca gagttgctca gcctgccagc aagaagatcg accagaacaa gctgaagccc     2340

gagatggacg agaagggcaa tctgaccaca gccggctttg cctgctctca gtgtggccag     2400

cctctgttcg tgtacaagct ggaacaggtg tccgagaaag gcaaggccta caccaactac     2460

ttcggcagat gtaacgtggc cgagcacgag aagctgattc tgctggccca gctgaaacct     2520

gagaaggact ctgatgaggc cgtgacctac agcctgggca agtttggaca gagagccctg     2580

gacttctaca gcatccacgt gaccaaagaa agcacacacc ccgtgaagcc cctggctcag     2640

atcgccggca atagatacgc ctctggacct gtgggcaaag ccctgtccga tgcctgcatg     2700

ggaacaatcg ccagcttcct gagcaagtac caggacatca tcatcgagca ccagaaggtg     2760

gtcaagggca accagaagag actggaaagc ctgagggagc tggccggcaa agagaacctg     2820

gaatacccca gcgtgaccct gcctcctcag cctcacacaa aagaaggcgt ggacgcctac     2880

aacgaagtga tcgccagagt gagaatgtgg gtcaacctga acctgtggca gaagctgaaa     2940

ctgtccaggg acgacgccaa gcctctgctg agactgaagg gcttccctag cttccctctg     3000

gtggaaagac aggccaatga agtggattgg tgggacatgg tctgcaacgt gaagaagctg     3060

atcaacgaga agaaagagga tggcaaggtt ttctggcaga acctggccgg ctacaagaga     3120

caagaagccc tgaggcctta cctgagcagc gaagaggacc ggaagaaggg caagaagttc     3180

gccagatacc agctgggcga cctgctgctg cacctggaaa agaagcacgg cgaggactgg     3240

ggcaaagtgt acgatgaggc ctgggagaga atcgacaaga aggtggaagg cctgagcaag     3300

cacattaagc tggaagagga aagaaggagc gaggacgccc aatctaaagc cgctctgacc     3360

gattggctga gagccaaggc cagctttgtg atcgagggcc tgaaagaggc cgacaaggac     3420

gagttctgca gatgcgagct gaagctgcag aagtggtacg gcgatctgag aggcaagccc     3480

ttcgccattg aggccgagaa cagcatcctg gacatcagcg gcttcagcaa gcagtacaac     3540

tgcgccttca tttggcagaa agacggcgtc aagaaactga acctgtacct gatcatcaat     3600

tacttcaaag gcggcaagct gcggttcaag aagatcaaac ccgaggcctt cgaggctaac     3660

agattctaca ccgtgatcaa caaaaagtcc ggcgagatcg tgcccatgga agtgaacttc     3720

aacttcgacg accccaacct gattatcctg cctctggcct tcggcaagag acagggcaga     3780

gagttcatct ggaacgatct gctgagcctg gaaaccggct ctctgaagct ggccaatggc     3840

agagtgatcg agaaaaccct gtacaacagg agaaccagac aggacgagcc tgctctgttt     3900

gtggccctga ccttcgagag aagagaggtg ctggacagca gcaacatcaa gcccatgaac     3960

ctgatcggcg tggaccgggg cgagaatatc cctgctgtga tcgccctgac agaccctgaa     4020

ggatgcccac tgagcagatt caaggactcc ctgggcaacc ctacacacat cctgagaatc     4080

ggcgagagct acaaagagaa gcagaggaca atccaggcca agaaagaggt ggaacagaga     4140

agagccggcg gatactctag gaagtacgcc agcaaggcca agaatctggc cgacgacatg     4200

gtccgaaaca ccgccagaga tctgctgtac tacgccgtga cacaggacgc catgctgatc     4260

ttcgagaatc tgagcagagg cttcggccgg cagggcaaga gaacctttat ggccgagagg     4320

cagtacacca gaatggaaga ttggctcaca gctaaactgg cctacgaggg actgagcaag     4380

acctacctgt ccaaaacact ggcccagtat acctccaaga cctgcagcaa ttgcggcttc     4440

accatcacca gcgccgacta cgacagagtg ctggaaaagc tcaagaaaac cgccaccggc     4500

tggatgacca ccatcaacgg caaagagctg aaggttgagg gccagatcac ctactacaac     4560

aggtacaaga ggcagaacgt cgtgaaggat ctgagcgtgg aactggacag actgagcgaa     4620

gagagcgtga acaacgacat cagcagctgg acaaagggca gatcaggcga ggctctgagc     4680

ctgctgaaga agaggtttag ccacagacct gtgcaagaga agttcgtgtg cctgaactgc     4740

ggcttcgaga cacacgccga tgaacaggct gccctgaaca ttgccagaag ctggctgttc     4800

ctgagaagcc aagagtacaa gaagtaccag accaacaaga ccaccggcaa caccgacaag     4860

agggcctttg tggaaacctg gcagagcttc tacagaaaaa agctgaaaga agtctggaag     4920

cccgccgtga ctagtccaaa aaagaagaga aaggtagccc tcgagtaccc atatgatgtc     4980

cctgactacg cttga                                                      4995


<210>  1005
<211>  5010
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP80 plasmid sequence

<400>  1005
atggcctctg gcagcaacgt ggaggaatac gagctggatg tggaagccct ggtggtcatc       60

ctgcgggaca gaaacatcgg aagaaatccc ctgcacggcg aaatcatcgg cctgagactg      120

accgagggct ggtggggcca gatcgagaga tttcagatgg tgcggctgat cctgcaggac      180

gacgacaacg agcccctgca gagaccccgc tacgaggtga tccccagagc cgtgaacccc      240

cacaccatgt tcatgatcag cggccccctg gctgaactgc agctggcctt ccaggacctg      300

gacctgcccg agggccctct gcggtttggc ccgctggcta acggccacta cgtgcagggg      360

gatccttaca gcagcagcta ccggcccgtg accatggccg aaacagccca gatgaccaga      420

gatgagctgg aagatatcct gaacacccaa agcgagatcg agatccagat gatcaacctg      480

ctggaacttt atgaggtgga aaccagagcc ctgagaagac agctggccga gagaagcagc      540

atcggccagg gaggagtgag ccccggcgct ccaaggccga gacctccagt tagcagcttc      600

agcggcctgc ctagcctgcc ttctatcccc ggcatccacc ccagagcccc ttcccctcct      660

cgcgctacaa gcacccctgg taacatcccc tggtccctgg gagatgacag cccacctagc      720

tcgtcttttc ctggccctag tcagcctaga gtgtctttcc accctggcaa tcctttcgtg      780

gaggacgagg gacatagacc tagatcccag agccgggaaa gacggagaaa caatcctcct      840

gcccctatcc ctagcgcccc tccaatgatc caatacgtgc ccgtgcctcc tccacctcct      900

gtcggaaccg tgatacctat ccaacacatc cggtccgtga ccggcgagcc tccaaagaac      960

ccccgagaaa tccccatctg gctgggccgg aatgcccctg ctatcgacgg cgttttcccc     1020

gtgacgaccc cagacctgcg gtgcagaatc atcaacgcca ttctgggagg caacctgggc     1080

ctgagcctga cacctgccga ctgtgtgacc tgggactctg ccgtgggcac cctgttcgtg     1140

cggacacacg gacagttccc tatgcaccag ctgggcacag tgatccaggg catcgtgaac     1200

caggagggcg tggctaccgc ttatacactg ggcatgatgc tgagcggcca gaattacccc     1260

ctcgtgagcg gcatcatcag aggctacctg cccggccagg ccgtggtgac cgcccttcag     1320

cagcgcctgg accaggaggt ggatgaccag gccagggctg aaaccttcat ccagcacctg     1380

aacgctgtgt acgagatcct gggcctcaac gccagaggac aatctatcag agccagcgtg     1440

acaccgcaac ctcggccaag ccggggccgc ggcagaggcc agtctacacc tagaccttcc     1500

cagggccctg tgagttcagg acggggcaga cagcggcctg ccagcggcca gtacgacaga     1560

ggcagcaaca accagaacca agaccagggt aacaccagcc agggcggcta caacctgaga     1620

ccaagaacct accagcctca gagatacggc ggcggaagag gtcggagatg gaacgagaac     1680

accaacagcc aggagagcag acccagcgat cagggctccc agacaccccg gcctaaccaa     1740

gctggcagcg gcgtcagagg caaccagagc cagaccccta gacccgccgc cggcagagga     1800

ggcagaggca atcagaatag aaaccagcgg tctagcggag ccggcgatag cagagccgtc     1860

aacacagtga cccagagtgc cacgtcctcc acagatgaat cctcttcagc tgttgcaacc     1920

gcttccagcg gagatcaaag gaactaaggt gccagagccg tcaacacagt gacccagggc     1980

ggcagcccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc     2040

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa     2100

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag     2160

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg     2220

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag     2280

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag     2340

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc     2400

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag     2460

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg     2520

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt     2580

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg     2640

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg     2700

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc     2760

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc     2820

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa     2880

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg     2940

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     3000

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     3060

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     3120

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     3180

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     3240

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     3300

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     3360

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     3420

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     3480

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     3540

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     3600

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     3660

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     3720

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     3780

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     3840

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     3900

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     3960

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     4020

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     4080

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     4140

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     4200

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     4260

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     4320

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     4380

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     4440

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     4500

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     4560

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     4620

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     4680

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     4740

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     4800

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     4860

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     4920

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt agccctcgag     4980

tacccatatg atgtccctga ctacgcttga                                      5010


<210>  1006
<211>  4663
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP81 plasmid sequence

<400>  1006
atggcccaga acgagacatt tgatcctgtg gccctgcagg gctactaccc tgctggcggc       60

atcctggccg acaatgacat tatcaacatc agattcacca gcggacagtg gggcatcggc      120

gatagatggc tgcaggtgcg gctgagactg gtggacccta atactggaca gcctctggct      180

cagcctgagt acgaggacac aggcctgcct gccgaaaaca ggggtatcgt ggtggccgtg      240

tcccacaacg ccgccagaaa tatcttcaac aacgtgcagc cagctggtgg ccccaacaga      300

cacggccctc tgcacgacgg ccaatttcaa gtgggcgacg atcccagcga gcacttcgtg      360

cctattgagg aaaacctgat cccccaggag atcgtgaacc tgggagcagc tagaagagaa      420

gtgcggctgc tgagagaaat gtgcgtgcgg ctgctgcacg tgagaagaca gatgatgggc      480

atgggcatgc ctggcgctat ccagcctcaa ccgccagtgg gccccctgcc cgcccctgcc      540

cagcccccta tccctggccc acctgtgcct ccccccgtgc ctccccccgc ccctccagcc      600

cctgtcaacc cccctgtccc tccagtgcag cctatccacc acctgcctat tacccacatc      660

cgggccgtga tcggcgagac acctgcccag atcagagatg tgcccctgtg gctggcccag      720

tccatccctg ccctgaccgg cgtttatcct gccatggacg ccggaacact gacaagactg      780

gtgaacgcga tcaccgccag acaccccgga ctcgctcttg gcatgaacga ggccggctcc      840

tggcacgagg ccgttcatct gatctggcag aggaccttcg gcgctacagc cctccatgcc      900

ttgtctgatg tgctgaaggg catcgcccag cggaacggcg tggtgatggc cctggaaatg      960

ggcctgatgt tcaccaacga cgactgggac ctgacctggt ctgtgatccg gagatgtctg     1020

cctggacaag ccagcgttgt gaccatccag gcccggctgg atgccctgcc aaacaaccag     1080

gccaggatca tccaggccgg ctttatcatc agagaggtgt acgaggtgct gggcctggac     1140

ccactgggcc ggccactgaa cttccctgga ggcctgaccc agcgagacac cgccgtgccc     1200

gtgaccagag gccggggccg cggaagaacc ggccctagaa gaggccctgt gctgcctgtc     1260

agcagcaacc agcgccggca agaaaccgca ggcggcaacc agcctcagac ccaaccccag     1320

cagcagaaca cattcagcaa tcagacaaat cagagaggaa accagcggca gtggcaaaat     1380

agaggaaccg acagccagag acggtacttc ttcagaccca gaccaagcca gcctcagcgg     1440

tacggcagca accagggccc tgacaaccct aatccctaca gaggaagaga tagcaccaat     1500

caaagcggcc aggagcggca gctgcctcag cagcaacagg gctctagaag gggccctggc     1560

agaaacacaa acagcggcaa caacaccgtg cacaccgtgc ggcaagtgga atcttctcag     1620

ctacaacaaa ggcggcagcc caaagaagaa gcggaaggtc tctagacaag agatcaagag     1680

aatcaacaag atcagaagga gactggtcaa ggacagcaac acaaagaagg ccggcaagac     1740

aggccccatg aaaaccctgc tcgtcagagt gatgacccct gacctgagag agcggctgga     1800

aaacctgaga aagaagcccg agaacatccc tcagcctatc agcaacacca gcagggccaa     1860

cctgaacaag ctgctgaccg actacaccga gatgaagaaa gccatcctgc acgtgtactg     1920

ggaagagttc cagaaagacc ccgtgggcct gatgagcaga gttgctcagc ctgccagcaa     1980

gaagatcgac cagaacaagc tgaagcccga gatggacgag aagggcaatc tgaccacagc     2040

cggctttgcc tgctctcagt gtggccagcc tctgttcgtg tacaagctgg aacaggtgtc     2100

cgagaaaggc aaggcctaca ccaactactt cggcagatgt aacgtggccg agcacgagaa     2160

gctgattctg ctggcccagc tgaaacctga gaaggactct gatgaggccg tgacctacag     2220

cctgggcaag tttggacaga gagccctgga cttctacagc atccacgtga ccaaagaaag     2280

cacacacccc gtgaagcccc tggctcagat cgccggcaat agatacgcct ctggacctgt     2340

gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc agcttcctga gcaagtacca     2400

ggacatcatc atcgagcacc agaaggtggt caagggcaac cagaagagac tggaaagcct     2460

gagggagctg gccggcaaag agaacctgga ataccccagc gtgaccctgc ctcctcagcc     2520

tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga gaatgtgggt     2580

caacctgaac ctgtggcaga agctgaaact gtccagggac gacgccaagc ctctgctgag     2640

actgaagggc ttccctagct tccctctggt ggaaagacag gccaatgaag tggattggtg     2700

ggacatggtc tgcaacgtga agaagctgat caacgagaag aaagaggatg gcaaggtttt     2760

ctggcagaac ctggccggct acaagagaca agaagccctg aggccttacc tgagcagcga     2820

agaggaccgg aagaagggca agaagttcgc cagataccag ctgggcgacc tgctgctgca     2880

cctggaaaag aagcacggcg aggactgggg caaagtgtac gatgaggcct gggagagaat     2940

cgacaagaag gtggaaggcc tgagcaagca cattaagctg gaagaggaaa gaaggagcga     3000

ggacgcccaa tctaaagccg ctctgaccga ttggctgaga gccaaggcca gctttgtgat     3060

cgagggcctg aaagaggccg acaaggacga gttctgcaga tgcgagctga agctgcagaa     3120

gtggtacggc gatctgagag gcaagccctt cgccattgag gccgagaaca gcatcctgga     3180

catcagcggc ttcagcaagc agtacaactg cgccttcatt tggcagaaag acggcgtcaa     3240

gaaactgaac ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc ggttcaagaa     3300

gatcaaaccc gaggccttcg aggctaacag attctacacc gtgatcaaca aaaagtccgg     3360

cgagatcgtg cccatggaag tgaacttcaa cttcgacgac cccaacctga ttatcctgcc     3420

tctggccttc ggcaagagac agggcagaga gttcatctgg aacgatctgc tgagcctgga     3480

aaccggctct ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt acaacaggag     3540

aaccagacag gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa gagaggtgct     3600

ggacagcagc aacatcaagc ccatgaacct gatcggcgtg gaccggggcg agaatatccc     3660

tgctgtgatc gccctgacag accctgaagg atgcccactg agcagattca aggactccct     3720

gggcaaccct acacacatcc tgagaatcgg cgagagctac aaagagaagc agaggacaat     3780

ccaggccaag aaagaggtgg aacagagaag agccggcgga tactctagga agtacgccag     3840

caaggccaag aatctggccg acgacatggt ccgaaacacc gccagagatc tgctgtacta     3900

cgccgtgaca caggacgcca tgctgatctt cgagaatctg agcagaggct tcggccggca     3960

gggcaagaga acctttatgg ccgagaggca gtacaccaga atggaagatt ggctcacagc     4020

taaactggcc tacgagggac tgagcaagac ctacctgtcc aaaacactgg cccagtatac     4080

ctccaagacc tgcagcaatt gcggcttcac catcaccagc gccgactacg acagagtgct     4140

ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc atcaacggca aagagctgaa     4200

ggttgagggc cagatcacct actacaacag gtacaagagg cagaacgtcg tgaaggatct     4260

gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac aacgacatca gcagctggac     4320

aaagggcaga tcaggcgagg ctctgagcct gctgaagaag aggtttagcc acagacctgt     4380

gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg aacaggctgc     4440

cctgaacatt gccagaagct ggctgttcct gagaagccaa gagtacaaga agtaccagac     4500

caacaagacc accggcaaca ccgacaagag ggcctttgtg gaaacctggc agagcttcta     4560

cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa agaagagaaa     4620

ggtagccctc gagtacccat atgatgtccc tgactacgct tga                       4663


<210>  1007
<211>  4528
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP82 plasmid sequence

<400>  1007
atggcccggg aactgaaccc cctgcagctg caacagctgt acatcaacaa tggcctgcag       60

cccaatcccg gccacggaga tatcatcgca gttagattca caggcggccc ttggggcccc      120

ggagatagat gggccagagt gaccatccgg ctgcaggaca acaccggcca gcctctgcaa      180

gtgcccggat acgacctgga gcctggcatc atcaatctgc gggaagatat cctgatcgcc      240

ggcccataca acctcatcag aacagctttt ctggacctgg aacctgccag aggaccagag      300

cggcacggcc cgttcggcga cggcagactg cagcctggcg atggactgag cgagggattt      360

cagcctatca ccgacgagga aatccaggct gaagtgggca ccatcggcgc cgcccgtaac      420

gagatccggc tgctgagaga agccttgcag agactccagg ctggcggtgt tggacggcct      480

atccctgggg ccgtgctgca gcctcaacct gtgatcggac ctgtgatccc catcaaccac      540

ctgagaagcg tgattggcaa cacacctcct aaccccagag atgtggccct gtggttgggc      600

agatctacag ccgctatcga gggcgtgttc cccatcgtgg accaggtgac ccggatgaga      660

gtggtgaacg ccctggtcgc ctctcatcct ggcctgaccc tgacagagaa cgaggccggc      720

agctggaacg ccgccatcag cgccctgtgg cggaaggccc acggcgctgc tgctcagcac      780

gagctggccg gagtgctgag cgacatcaac aagaaggaag gcatccagac agccttcaac      840

ctgggcatgc agttcaccga tggcaattgg tccctggtgt ggggaatcat caggaccctg      900

ctgcccggcc aggccctggt cacaaacgcc cagagccagt tcgacctgat gggcgacgac      960

attcagcggg ccgagaactt ccccagagtg attaacaacc tgtacaccat gctgggcctg     1020

aacatccacg gccagagcat cagacctaga gtgcagaccc agcctctgca gaccagacct     1080

cggaaccctg gcagaagcca gcagggtcag ctgaatcagc ctcggcctca gaacagagcc     1140

aaccagtcct acagaccccc tcggcagcag caacaacaca gcgacgtgcc tgagcagagg     1200

gaccagagag gcccatctca accgcctaga ggctctggcg gaggctataa cttcagaaga     1260

aatccccagc agcctcagcg gtacggccaa ggcccccccg gcccaaaccc ttacagacgg     1320

ttcggcgacg gcggcaatcc ccagcagcaa ggcccgcctc caaatagagg ccctgatcag     1380

ggacctagac caggcggcaa ccctcgcggc ggcggcaggg ggcagggccc ccggaacggc     1440

ggaggcagcg ccgccgccgt gcacaccgtg aaagccagcg aaaacgaaac taaaaggcgg     1500

cagcccaaag aagaagcgga aggtctctag acaagagatc aagagaatca acaagatcag     1560

aaggagactg gtcaaggaca gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac     1620

cctgctcgtc agagtgatga cccctgacct gagagagcgg ctggaaaacc tgagaaagaa     1680

gcccgagaac atccctcagc ctatcagcaa caccagcagg gccaacctga acaagctgct     1740

gaccgactac accgagatga agaaagccat cctgcacgtg tactgggaag agttccagaa     1800

agaccccgtg ggcctgatga gcagagttgc tcagcctgcc agcaagaaga tcgaccagaa     1860

caagctgaag cccgagatgg acgagaaggg caatctgacc acagccggct ttgcctgctc     1920

tcagtgtggc cagcctctgt tcgtgtacaa gctggaacag gtgtccgaga aaggcaaggc     1980

ctacaccaac tacttcggca gatgtaacgt ggccgagcac gagaagctga ttctgctggc     2040

ccagctgaaa cctgagaagg actctgatga ggccgtgacc tacagcctgg gcaagtttgg     2100

acagagagcc ctggacttct acagcatcca cgtgaccaaa gaaagcacac accccgtgaa     2160

gcccctggct cagatcgccg gcaatagata cgcctctgga cctgtgggca aagccctgtc     2220

cgatgcctgc atgggaacaa tcgccagctt cctgagcaag taccaggaca tcatcatcga     2280

gcaccagaag gtggtcaagg gcaaccagaa gagactggaa agcctgaggg agctggccgg     2340

caaagagaac ctggaatacc ccagcgtgac cctgcctcct cagcctcaca caaaagaagg     2400

cgtggacgcc tacaacgaag tgatcgccag agtgagaatg tgggtcaacc tgaacctgtg     2460

gcagaagctg aaactgtcca gggacgacgc caagcctctg ctgagactga agggcttccc     2520

tagcttccct ctggtggaaa gacaggccaa tgaagtggat tggtgggaca tggtctgcaa     2580

cgtgaagaag ctgatcaacg agaagaaaga ggatggcaag gttttctggc agaacctggc     2640

cggctacaag agacaagaag ccctgaggcc ttacctgagc agcgaagagg accggaagaa     2700

gggcaagaag ttcgccagat accagctggg cgacctgctg ctgcacctgg aaaagaagca     2760

cggcgaggac tggggcaaag tgtacgatga ggcctgggag agaatcgaca agaaggtgga     2820

aggcctgagc aagcacatta agctggaaga ggaaagaagg agcgaggacg cccaatctaa     2880

agccgctctg accgattggc tgagagccaa ggccagcttt gtgatcgagg gcctgaaaga     2940

ggccgacaag gacgagttct gcagatgcga gctgaagctg cagaagtggt acggcgatct     3000

gagaggcaag cccttcgcca ttgaggccga gaacagcatc ctggacatca gcggcttcag     3060

caagcagtac aactgcgcct tcatttggca gaaagacggc gtcaagaaac tgaacctgta     3120

cctgatcatc aattacttca aaggcggcaa gctgcggttc aagaagatca aacccgaggc     3180

cttcgaggct aacagattct acaccgtgat caacaaaaag tccggcgaga tcgtgcccat     3240

ggaagtgaac ttcaacttcg acgaccccaa cctgattatc ctgcctctgg ccttcggcaa     3300

gagacagggc agagagttca tctggaacga tctgctgagc ctggaaaccg gctctctgaa     3360

gctggccaat ggcagagtga tcgagaaaac cctgtacaac aggagaacca gacaggacga     3420

gcctgctctg tttgtggccc tgaccttcga gagaagagag gtgctggaca gcagcaacat     3480

caagcccatg aacctgatcg gcgtggaccg gggcgagaat atccctgctg tgatcgccct     3540

gacagaccct gaaggatgcc cactgagcag attcaaggac tccctgggca accctacaca     3600

catcctgaga atcggcgaga gctacaaaga gaagcagagg acaatccagg ccaagaaaga     3660

ggtggaacag agaagagccg gcggatactc taggaagtac gccagcaagg ccaagaatct     3720

ggccgacgac atggtccgaa acaccgccag agatctgctg tactacgccg tgacacagga     3780

cgccatgctg atcttcgaga atctgagcag aggcttcggc cggcagggca agagaacctt     3840

tatggccgag aggcagtaca ccagaatgga agattggctc acagctaaac tggcctacga     3900

gggactgagc aagacctacc tgtccaaaac actggcccag tatacctcca agacctgcag     3960

caattgcggc ttcaccatca ccagcgccga ctacgacaga gtgctggaaa agctcaagaa     4020

aaccgccacc ggctggatga ccaccatcaa cggcaaagag ctgaaggttg agggccagat     4080

cacctactac aacaggtaca agaggcagaa cgtcgtgaag gatctgagcg tggaactgga     4140

cagactgagc gaagagagcg tgaacaacga catcagcagc tggacaaagg gcagatcagg     4200

cgaggctctg agcctgctga agaagaggtt tagccacaga cctgtgcaag agaagttcgt     4260

gtgcctgaac tgcggcttcg agacacacgc cgatgaacag gctgccctga acattgccag     4320

aagctggctg ttcctgagaa gccaagagta caagaagtac cagaccaaca agaccaccgg     4380

caacaccgac aagagggcct ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa     4440

agaagtctgg aagcccgccg tgactagtcc aaaaaagaag agaaaggtag ccctcgagta     4500

cccatatgat gtccctgact acgcttga                                        4528


<210>  1008
<211>  4977
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP83 plasmid sequence

<400>  1008
atggccgctg tggaaggcga tctggacgtg caagccctga ccgatctgtt caacaacctg       60

ggcatcaacc gggacccccg gcaccgggaa gtgatcgccc tgcggatgac aggcggctgg      120

tggggccctg ccaccagata caacctgatc accgtgctgc tgcaggatga tcagggtcag      180

cctcttcagc agccccggtg gcgggccgag ggccgggccg ccaaccccgc tgtgatgctg      240

accctggaag ccccatggca ggacctgcgg atggcctttg acaacgtcga cctggccgac      300

gacacactgc ggtttggccc tctggctaac ggcaattaca tccccggcga cgagtacagc      360

ctggagttca tccctcccgc catgcaagag atcgcccaaa tgcagagaga tgagctggaa      420

aacgtgctgg acattgtggg ccagatcaca atgcagatga gcgacctgat cggaatgcag      480

gacgcccaga tccggggcct ggagggccaa atcagaggcc tgagaggcaa tctgcccgtg      540

gccggaacac caccacctcc tcctccaagc ctggacctgc agcctgccgc cgccagcagc      600

ccttacgtgg cccctgcgtc tagcgctcct gccgcacccg tggcctctgc tgatctgggc      660

tggttcgccg ggggaccttc cccaggctct gtggaccctc ggctggcccg ggtcgcctac      720

aaccccttcc tgcccggacc tagcgacggc agcggcgtgg ccccggtgca gccctccgcc      780

cctcctgccg ccagccctct gctgcccctg ccacctgctc agcctgtgca gccagtgatc      840

cagtacgtgc accctcctcc tatgaaccct gcccagcaga ttattcctat ccagcacatc      900

agagccgtga ccggcaacgc ccccaccaac cctagagaga tccctatgtg gatcggcaga      960

aacgccagcg ccatcgaggg cgtgttcccc atgaccaccc ctgatctgag gtgtcgggtg     1020

atcaacgccc tgctcggcgg caacctgggc ctgaacctgg aaccacagca ctgcgtgacc     1080

tgggccagcg caatcgccac cctgtacgtt agaacccacg gcagctaccc catccaccag     1140

ctggctgaag tgctgagagg cgtggctaat agcgagggag ttgctgccgc ttatcagctg     1200

ggcatgatgc tgacaaaccg ggattacaac ctgatctggg ggatcatccg ccctctgctg     1260

cccggccagg ccgtcgtgac cgccatgcag catagactgg atcaggagat caacgacgcc     1320

gccagagtgg cctctttcat caatcacctg aacggcgtgt acgagctgct gggcttgaac     1380

gccagaggcc agagcctgag aatccctgcc tctggcggac agaccacggc cggaaccagc     1440

gccggcagag gcacaagagg aagacgcagc cagcaaggca cacctggcag acagagcagc     1500

ggccagagcc agcagcaggg aagaagaagc agccagggcc agagcagaca gtcagactcc     1560

agcgaccaga acgtgcagag acaatcccag ggcggcaacg gacggggagg ctataatctg     1620

agacccagga cctaccagcc ccagagatac ggcggaggca gaggcagaag gtggaacgac     1680

cagcctgcca gatcagacaa ccagcagcgg tcccaatctc aacagcctca gtccgaggct     1740

agaggcgagc agagcagaac cagcggagcc ggcagaggac agggcggccg ggggaatcaa     1800

aacagaaacc agagaagcgc cggtggcaat gccgacagaa cagtgaacac cgtgacaacc     1860

gccagcgctt ctacaagcgc ctcaggtcaa gatggatcct ctccagctcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaggcggc agcccaaaga agaagcggaa ggtctctaga     1980

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     2040

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     2100

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     2160

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     2220

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     2280

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     2340

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     2400

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     2460

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     2520

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     2580

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     2640

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     2700

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     2760

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     2820

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     2880

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     2940

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     3000

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     3060

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     3120

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     3180

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     3240

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     3300

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     3360

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     3420

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     3480

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     3540

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     3600

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     3660

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     3720

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     3780

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     3840

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     3900

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     3960

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     4020

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     4080

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     4140

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     4200

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     4260

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     4320

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     4380

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     4440

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     4500

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     4560

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     4620

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     4680

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     4740

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     4800

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     4860

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     4920

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        4977


<210>  1009
<211>  4977
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP84 plasmid sequence

<400>  1009
atggccgcca tcgagggcga tctggacgtg caggccctgg ctaacctgtt caacgacctg       60

ggcatcaaca gaaaccccag acacagagag gtgattgccc tgagaatgac cggcggctgg      120

tggggccccg ctaccagata taatctggtg agcctgctgc tgcaggacga ccagggccag      180

cctctgccac agcccagatg gcgggctgaa ggcagagccg caaaccccgc cgtgatgttc      240

accctggaag ccccctggca ggatctgaga ctggcctttg acaatatcga cgtgggcgag      300

ggcacactga gattcggccc acttgctaac ggcaactaca tccccggcga cgagttcagc      360

ctggagttcc tgcctcctgc catgcaggag atcacacaga tgcagagaga tgagctggag      420

gaagtgctgg atgtggtggg ccagatcaca atgcagatga acgacctgat cggcatgcag      480

gacgcccaga tccggggact ggaaggacaa ctgagaggac tgagaggcaa tctgccagtg      540

gccggcacac ctccacctcc tccacccagc ctggacctgc agcctgctgc cgccagcagc      600

ccctacgtgg cccctgcacc ttccgctcct gctgcctctg ccgccgcagc cgacctggga      660

tggttcgccg gaggccctgg ccctggatct ctggaccccc gcctcgcccg ggtggcctac      720

aacccctttc tgcctggccc tagcgacggc agcggtgccg ctcccgccca gcctagcgct      780

cctccggtgg cctctcctct gccttctctg ctgcctgccc agcccatgca acctgtgatc      840

cagtacgtgc accccccacc tatcaatcct gctcaacagg tgatccctat tcagcatatc      900

agagccgtga ccggcaacgc ccctagcaac ccaagagaaa tccctatgtg gatcggaaga      960

aacgccagcg ccatcgaggg cgtgttcccc atccctacat ctgacatccg ttctagagtg     1020

atcaacgccc tgctgggtag acagctgggc ctgaacctgg atcctcagca ctgcatcacc     1080

tgggccagcg caatcgccac tctgtacgtg cgcacccacg gcagctaccc tctgcaccag     1140

ctggccgagg ttctgcggag agtctccaac agcgaaggcg cggccgccgc ctggcagctg     1200

ggcatgatgc tgaccaacca ggactacaac ctcgtgtggg gaatggtcag acccctgctg     1260

cccggccagg ctgtggtcac cgccatgcag caccggctgg atcaggaggt ttctgatgcc     1320

gccagaatcg tgtccttcgt gaaccacctg aacgccgtgt acgagctgct gggcctgaat     1380

gccagaggcc agaacctcag ggtctccacc ggcggccaga ccaccgctag aacaagcgcc     1440

ggcagaggcg ccagaggcag acggtcccag caggggaccc ctggcaggca gtctagcgga     1500

caggcccctc ctcaaggccg gagaagcagc cagggccagc agcctaggca gtctgagagc     1560

ggcgaccaga acaaccagcg gcagctccag ggaggaaaca accggggcgg ctataacctg     1620

cggcctcgga cataccagcc tcagcggtac gggggaggcc ggggccggag atggaacgat     1680

cagaccgcca gagccgataa ccagcagcgg agccaatccc aacaacctca gagcgaggcc     1740

cggggcgagc agagcagaac cagcggcgcc ggcagagaac agggcggcag aggcaatcaa     1800

aatcggaatc aaagatctgc cggagaaaac accgacagat ccgtgaacac cgtgacagcc     1860

accagcgcca gcatcagcgc ctcaggtcaa aatggatcct ctacaactcc tccagcctct     1920

ggaagcggaa atcaagggaa ctaaggcggc agcccaaaga agaagcggaa ggtctctaga     1980

caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag     2040

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg     2100

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac     2160

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc     2220

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct     2280

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc     2340

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag     2400

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg     2460

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag     2520

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac     2580

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac     2640

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc     2700

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag     2760

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc     2820

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga     2880

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc     2940

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     3000

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     3060

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     3120

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     3180

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     3240

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     3300

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     3360

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     3420

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     3480

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     3540

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     3600

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     3660

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     3720

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     3780

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     3840

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     3900

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     3960

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     4020

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     4080

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     4140

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     4200

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     4260

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     4320

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     4380

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     4440

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     4500

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     4560

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     4620

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     4680

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     4740

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     4800

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     4860

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt gactagtcca     4920

aaaaagaaga gaaaggtagc cctcgagtac ccatatgatg tccctgacta cgcttga        4977


<210>  1010
<211>  5
<212>  PRT
<213>  Unknown

<220>  
<223>  TEV protease cleavage site

<400>  1010

Leu Phe Gln Gly Pro 
1               5   


