                         SEQUENCE LISTING

<110>  THE UNIVERISTY OF NORTH CAROLINA AT CHAPEL HILL
 
<120>  AFFINITY MOLECULES THAT DIRECT THE METABOLISM AND POLARIZATION OF
        MACROPHAGES AND SYNERGIZE THE IMMUNE CHECKPOINT BLOCKADE THERAPY

<130>  UNC2-38170-601

<150>  US 62/944,849
<151>  2019-12-06

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  1

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asn Val Ser Tyr Glu 
            20                  25                  30          


Asn Ile Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Thr Asp Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser His Asp Asn Ser Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Val Asp Val Ser Pro Val Gln Ala Val Asp Glu Ala Leu Arg 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Val Ser Tyr Glu 
            20                  25                  30          


Asn Met Ala Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Thr Asp Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Val Asp Val Ser Pro Val Gln Ala Val Asp Glu Ala Leu Arg 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  3
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asn Val Asn Tyr Glu 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Thr Asp Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Val Asp Val Ser Pro Val Gln Thr Val Asp Glu Ala Leu Arg 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  4
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asn Val Ser Tyr Glu 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Thr Asp Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Val Asp Val Ser Pro Val Gln Ala Val Asp Glu Ala Leu Arg 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  5
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Pro Asn Asp Lys 
            20                  25                  30          


Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Thr Asp Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gln Gly Glu Leu Asp Ser Pro Leu Ser Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  6
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asn Ile Ile Thr Lys 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Glu Asp Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Leu Val Asp His Glu Asp Ser Met Thr Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Val Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Leu Trp Gly Ser Gly Gly Thr Glu Tyr Asn Ser Asn Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gln Gly Leu Asn Tyr Gly Ser Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8

Tyr Glu Asn Ile Ala 
1               5   


<210>  9
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9

Thr Ile Asn Thr Asp Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  10
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  10

Val Asp Val Ser Pro Val Gln Ala Val Asp Glu Ala Leu Arg Phe 
1               5                   10                  15  


<210>  11
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  11

Tyr Glu Asn Met Ala Thr Ile Asn Thr Asp Asp Gly Ser Thr Tyr Tyr 
1               5                   10                  15      


Ala Asp Ser Val Lys Gly 
            20          


<210>  12
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12

Tyr Glu Asn Met Ala 
1               5   


<210>  13
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13

Thr Ile Asn Thr Asp Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14

Val Asp Val Ser Pro Val Gln Thr Val Asp Glu Ala Leu Arg Phe 
1               5                   10                  15  


<210>  15
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15

Asp Lys Phe Met Ser 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16

Thr Ile Thr Asp Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17

Gly Gln Gly Glu Leu Asp Ser Pro Leu Ser Tyr 
1               5                   10      


<210>  18
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18

Thr Lys Asp Met Gly 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19

Ser Ile Glu Asp Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20

Leu Val Asp His Glu Asp Ser Met Thr Ser 
1               5                   10  


<210>  21
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21

Val Tyr Ser Val His 
1               5   


<210>  22
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22

Ala Leu Trp Gly Ser Gly Gly Thr Glu Tyr Asn Ser Asn Leu Lys Ser 
1               5                   10                  15      


<210>  23
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  23

Arg Asp Gln Gly Leu Asn Tyr Gly Ser Leu Phe Asp Tyr 
1               5                   10              


