
                                SEQUENCE LISTING

<110> ImaginAb, Inc.
      Mascioni, Alessandro
      Wilson, Ian Andrew
      Plavec, Ivan
      Le, William Huy

<120> METHODS OF IMAGING USING MULTIPLE
  IMAGING AGENTS

<130> IGNAB.050WO

<150> 62/944183           
<151> 2019-12-05  

<160> 265

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 118
<212> PRT
<213> Murine

<400> 1
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Cys Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 2
<211> 120
<212> PRT
<213> Homo sapiens

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 3
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 4
<211> 118
<212> PRT
<213> Murine

<400> 4
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Cys Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 5
<211> 115
<212> PRT
<213> Homo sapiens

<400> 5
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Ala Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 6
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 7
<211> 107
<212> PRT
<213> Murine

<400> 7
Asp Val Gln Ile Asn Gln Ser Pro Ser Phe Leu Ala Ala Ser Pro Gly
 1               5                  10                  15      
Glu Thr Ile Thr Ile Asn Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 8
<211> 107
<212> PRT
<213> Homo sapiens

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 9
Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 10
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 10
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Asn Gln Ser Pro Ser Phe Leu Ala
            20                  25                  30          
Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Gly Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly
145                 150                 155                 160 
Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala
    210                 215                 220                 
Tyr Met His Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Thr Leu Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 11
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 11
atggagacag acaccctgct cctgtgggtg ctgctcctct gggtccctgg atccaccggc 60
gatgtccaga tcaaccaaag ccccagcttt ctggctgcct cccctggaga gacaatcacc 120
atcaattgcc ggaccagccg gagcatttcc cagtacctcg cctggtacca ggaaaagcct 180
ggcaagacca acaagctgct gatctactcc ggctccacac tccagagcgg cattccctcc 240
aggtttagcg gatccggatc cggaaccgac ttcacactca ccatctccgg cctggagccc 300
gaggacttcg ccatgtatta ttgccagcag cacaatgaga accccctgac cttcggcgct 360
ggcaccaagc tggagctgaa aggctccacc agcggaggcg gatccggagg aggaagcggc 420
ggcggaggct cctccgaagt gcagctgcaa cagagcggcg ccgaactggt gaagcctgga 480
gcttccgtga aactcagctg taccgccagc ggcttcaaca tcaaggatac ctacatccac 540
ttcgtgcggc aaaggcctga gcagggcctg gaatggatcg gcaggatcga ccccgccaac 600
gacaacaccc tctacgcctc caagttccaa ggcaaggcca caatcaccgc tgatacaagc 660
tccaacaccg cctacatgca cctcagctcc ctgaccagcg gagacaccgc cgtgtactac 720
tgcggacggg gatacggcta ctatgtgttc gaccactggg gccaaggcac cacactcacc 780
gtgtcctccg agcccaagtc ctgcgacaag acacacacct gtcccccttg tggaggagga 840
tcctccggag gcggctccgg cggacagcct agggagcccc aggtgtacac actgccccct 900
tccagggacg aactcaccaa gaaccaggtg tccctgacct gcctggtgaa gggattctac 960
cccagcgaca tcgccgtgga gtgggagtcc aacggccaac ccgagaacaa ttacaagacc 1020
accccccctg tgctcgattc cgacggctcc ttcttcctgt actccaagct caccgtggac 1080
aagtcccggt ggcaacaggg caatgtgttc tcctgcagcg tcatgcacga ggccctgcat 1140
aaccactaca cccagaaatc cctcagcctc tcccctggaa aatga                 1185

<210> 12
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 12
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
        35                  40                  45              
Ile Lys Asp Thr Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
65                  70                  75                  80  
Ala Ser Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser
                85                  90                  95      
Asn Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
        115                 120                 125             
Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Ser Thr Ser Gly Gly
    130                 135                 140                 
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Val Gln Ile
145                 150                 155                 160 
Asn Gln Ser Pro Ser Phe Leu Ala Ala Ser Pro Gly Glu Thr Ile Thr
                165                 170                 175     
Ile Asn Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala Trp Tyr
            180                 185                 190         
Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly Ser
        195                 200                 205             
Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro Glu Asp Phe Ala
225                 230                 235                 240 
Met Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu Thr Phe Gly Ala
                245                 250                 255     
Gly Thr Lys Leu Glu Leu Lys Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 13
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 13
atggagaccg acacactcct gctctgggtg ctcctgctgt gggtgcctgg cagcacagga 60
gaagtgcagc tgcagcagtc cggcgccgaa ctcgtcaaac ccggagcctc cgtcaaactg 120
tcctgcacag ccagcggctt caacatcaag gacacctaca tccatttcgt gcggcaaagg 180
cctgaacagg gactcgagtg gatcggcagg atcgaccccg ccaacgacaa taccctctac 240
gcctccaagt tccagggaaa ggccaccatt accgccgaca catccagcaa caccgcctac 300
atgcacctca gctccctgac atccggcgac accgccgtgt actactgcgg caggggctac 360
ggctactacg tgtttgacca ctggggccag ggaacaaccc tgaccgtgtc cagcggctcc 420
acctccggag gcggaagcgg cggaggatcc ggaggaggag gctcctccga cgtgcaaatc 480
aaccagtccc ctagcttcct ggccgctagc cctggcgaga caatcacaat caattgtcgg 540
accagccggt ccatctccca gtatctggcc tggtaccagg agaagcccgg caagacaaac 600
aagctgctca tctacagcgg cagcaccctc caatccggca tcccttcccg gtttagcggc 660
tccggatccg gaaccgactt taccctgacc atcagcggcc tggaacccga ggatttcgcc 720
atgtactact gccagcagca caacgagaat cccctgacct ttggagccgg cacaaagctc 780
gagctgaagg agcccaagag ctgcgacaaa acccacacct gtcccccttg cggaggagga 840
tcctccggcg gcggaagcgg aggacaaccc agggagcccc aggtctacac cctgcctcct 900
agccgggacg aactgacaaa gaaccaggtg tccctgacct gtctcgtcaa gggcttctac 960
ccttccgaca tcgccgtcga gtgggaaagc aacggccagc ccgagaacaa ttacaagacc 1020
acaccccccg tcctggacag cgatggcagc ttcttcctct actccaagct gaccgtggac 1080
aagagccggt ggcaacaagg caacgtgttc tcctgcagcg tcatgcatga ggccctgcac 1140
aatcactaca cccagaagag cctgagcctc tcccccggca agtga                 1185

<210> 14
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 14
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
145                 150                 155                 160 
Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala
    210                 215                 220                 
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 15
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 15
atggagacag acaccctcct gctgtgggtc ctgctgctgt gggtgcctgg cagcacagga 60
gacatccaaa tgacccagtc ccctagcagc ctcagcgctt ccgtcggaga cagggtcacc 120
atcacatgca ggacctccag gtccatcagc cagtatctgg cctggtatca gcagaaaccc 180
ggcaaggtgc ctaagctgct gatctacagc ggcagcacac tccagagcgg agtgcccagc 240
cggttttccg gaagcggatc cggaaccgac ttcaccctga ccatttccag cctgcaacct 300
gaagacgtgg ccacctacta ctgtcagcag cacaacgaga accccctcac cttcggcgga 360
ggcaccaaag tcgagatcaa gggcagcacc agcggaggag gaagcggcgg aggctccgga 420
ggaggaggct cctcccaagt gcagctcgtc caaagcggcg ctgaggtgaa aaagcccggc 480
gccacagtca aaatctcctg caaggtcagc ggcttcaaca tcaaggatac ctacatccac 540
tgggtgcaac aggcccccgg caaaggactc gaatggatgg gccggatcga ccctgctaac 600
gacaacacac tctacgcctc caagttccag ggcagggtga ccatcaccgc cgatacctcc 660
accgacacag cctacatgga gctgagcagc ctgaggtccg aggacaccgc cgtctattac 720
tgcgcccggg gatacggcta ctacgtgttt gaccattggg gacagggaac actcgtgacc 780
gtgagctccg agcccaagag ctgcgacaag acccacacat gtcctccttg cggaggaggc 840
agctccggag gcggatccgg cggacaacct agggagcccc aggtctatac cctgcccccc 900
agcagggacg agctgacaaa gaaccaggtc tccctgacct gcctggtgaa aggattctac 960
cccagcgaca tcgctgtcga atgggagtcc aacggccagc ccgagaacaa ctacaagaca 1020
accccccccg tgctggattc cgacggcagc ttcttcctct actccaagct gaccgtcgac 1080
aagtccaggt ggcagcaggg caacgtgttt tcctgctccg tgatgcatga ggccctgcac 1140
aaccactaca cccagaagtc cctgagcctc agccctggca agtga                 1185

<210> 16
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn
        35                  40                  45              
Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
65                  70                  75                  80  
Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
                85                  90                  95      
Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly
    130                 135                 140                 
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln Met
145                 150                 155                 160 
Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                165                 170                 175     
Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala Trp Tyr
            180                 185                 190         
Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Ser Gly Ser
        195                 200                 205             
Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala
225                 230                 235                 240 
Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu Thr Phe Gly Gly
                245                 250                 255     
Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 17
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 17
atggagaccg atacactgct gctctgggtg ctgctgctgt gggtgcctgg aagcaccgga 60
caggtgcaac tggtccagtc cggcgccgag gtgaaaaagc ctggcgccac cgtcaagatc 120
tcctgtaagg tgagcggctt caacatcaag gacacctaca tccactgggt gcagcaggct 180
cccggaaagg gactggagtg gatgggcagg atcgaccctg ccaatgacaa caccctctac 240
gccagcaagt tccaaggacg ggtgaccatc acagccgaca catccaccga cacagcctat 300
atggagctct ccagcctgag gtccgaggac accgccgtgt actactgtgc caggggatac 360
ggctattacg tgttcgacca ctggggacag ggcaccctgg tgaccgtgag cagcggaagc 420
accagcggcg gaggcagcgg aggcggaagc ggcggcggcg gatcctccga cattcagatg 480
acccaatccc cctccagcct gtccgctagc gtgggagaca gggtgacaat cacatgtcgg 540
acctccaggt ccatcagcca atatctcgcc tggtatcagc agaagcccgg caaggtgccc 600
aagctcctga tctacagcgg ctccaccctc caaagcggag tgccttcccg gtttagcgga 660
agcggcagcg gcacagactt taccctgaca atcagctccc tgcaacctga ggacgtcgcc 720
acatactact gccagcagca caacgagaac cctctcacct ttggcggcgg caccaaagtg 780
gagatcaagg agcccaaatc ctgcgacaag acacacacct gccccccttg tggaggaggc 840
agctccggcg gcggcagcgg cggacaaccc cgggaacctc aggtgtatac actcccccct 900
tccagggatg agctgaccaa gaaccaagtc tccctgacct gtctggtgaa aggcttctac 960
ccctccgaca tcgctgtcga gtgggagagc aacggccagc ccgaaaacaa ctataagacc 1020
accccccccg tgctcgattc cgatggcagc ttcttcctgt actccaagct cacagtcgac 1080
aagagccggt ggcaacaggg caacgtcttc tcctgtagcg tcatgcacga ggccctccac 1140
aaccactaca cccagaagtc cctctccctg agccccggaa aatga                 1185

<210> 18
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 18
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ser
        115                 120                 125             
Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
    130                 135                 140                 
Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn
145                 150                 155                 160 
Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly
                165                 170                 175     
Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
            180                 185                 190         
Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
        195                 200                 205             
Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
    210                 215                 220                 
Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
225                 230                 235                 240 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 19
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 19
atggagaccg atacactgct gctgtgggtg ctgctgctct gggtccctgg cagcacagga 60
gacatccaga tgacacagag ccctagctcc ctgagcgctt ccgtgggaga tagggtgacc 120
atcacatgcc ggacctccag gtccatctcc cagtacctgg cctggtacca gcagaagccc 180
ggcaaggtgc ccaagctgct catctatagc ggcagcaccc tgcagagcgg agtgccttcc 240
cggttttccg gatccggctc cggcacagac tttaccctga ccatctccag cctgcagcct 300
gaggatgtcg ccacctacta ctgccaacag cacaacgaga accccctgac cttcggcggc 360
ggaaccaagg tcgagatcaa gtccggagga ggaggccaag tgcagctggt ccaatccggc 420
gccgaagtga aaaagcccgg cgccaccgtg aagatcagct gcaaggtgtc cggcttcaac 480
atcaaggaca cctatatcca ctgggtccag caagcccccg gaaaaggcct ggagtggatg 540
ggacggattg accccgccaa cgacaacaca ctctatgcct ccaagttcca gggcagggtg 600
acaatcaccg ccgacaccag caccgacaca gcttatatgg agctgtcctc cctccggtcc 660
gaggataccg ccgtctacta ctgcgccagg ggctacggct actacgtgtt tgaccactgg 720
ggccagggca ccctggtgac agtgtccagc ggaggctgc                        759

<210> 20
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 20
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
145                 150                 155                 160 
Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala
    210                 215                 220                 
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 21
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 21
atggagaccg acaccctgct gctctgggtc ctcctgctgt gggtgcctgg cagcacagga 60
caggtgcaac tggtgcagag cggcgccgag gtcaagaaac ctggcgccac cgtgaagatc 120
agctgcaagg tgtccggctt caacatcaag gacacctaca tccactgggt ccaacaagcc 180
cccggaaagg gcctggaatg gatgggccgg attgaccccg ccaacgacaa caccctctat 240
gccagcaagt tccagggcag ggtcaccatc accgccgaca ccagcaccga caccgcctac 300
atggagctga gcagcctgcg gagcgaagac accgccgtgt actactgcgc caggggctac 360
ggctactacg tcttcgacca ttggggacag ggcaccctcg tgacagtgtc cagctccggc 420
ggaggaggag atatccagat gacccagagc ccttccagcc tgtccgcttc cgtgggagat 480
cgggtgacca tcacatgcag gacctccagg tccatctccc agtacctggc ctggtaccaa 540
cagaagcccg gcaaggtgcc caagctgctg atctacagcg gcagcacact gcaatccggc 600
gtcccttccc ggttttccgg atccggatcc ggcaccgact tcaccctgac catcagctcc 660
ctgcaacccg aggacgtggc cacctactac tgtcagcagc acaacgagaa ccccctcacc 720
tttggcggcg gaaccaaggt cgagatcaag ggcggctgc                        759

<210> 22
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 22
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala
    130                 135                 140                 
Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser
145                 150                 155                 160 
Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro
                165                 170                 175     
Gly Lys Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn
            180                 185                 190         
Thr Leu Tyr Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp
        195                 200                 205             
Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu
    210                 215                 220                 
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe
225                 230                 235                 240 
Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250                 255     


<210> 23
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 23
atggagaccg atacactgct gctgtgggtg ctgctgctct gggtccctgg cagcacagga 60
gacatccaga tgacacagag ccctagctcc ctgagcgctt ccgtgggaga tagggtgacc 120
atcacatgcc ggacctccag gtccatctcc cagtacctgg cctggtacca gcagaagccc 180
ggcaaggtgc ccaagctgct catctatagc ggcagcaccc tgcagagcgg agtgccttcc 240
cggttttccg gatccggctc cggcacagac tttaccctga ccatctccag cctgcagcct 300
gaggatgtcg ccacctacta ctgccaacag cacaacgaga accccctgac cttcggcggc 360
ggaaccaagg tcgagatcaa gggaggaggc tccggaggag gaggccaagt gcagctggtc 420
caatccggcg ccgaagtgaa aaagcccggc gccaccgtga agatcagctg caaggtgtcc 480
ggcttcaaca tcaaggacac ctatatccac tgggtccagc aagcccccgg aaaaggcctg 540
gagtggatgg gacggattga ccccgccaac gacaacacac tctatgcctc caagttccag 600
ggcagggtga caatcaccgc cgacaccagc accgacacag cttatatgga gctgtcctcc 660
ctccggtccg aggataccgc cgtctactac tgcgccaggg gctacggcta ctacgtgttt 720
gaccactggg gccagggcac cctggtgaca gtgtccagcg gaggctgc              768

<210> 24
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 24
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn
        35                  40                  45              
Ile Lys Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr
65                  70                  75                  80  
Ala Ser Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr
                85                  90                  95      
Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
145                 150                 155                 160 
Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser
                165                 170                 175     
Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu
            180                 185                 190         
Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe
        195                 200                 205             
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
    210                 215                 220                 
Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn
225                 230                 235                 240 
Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250                 255     


<210> 25
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 25
atggagaccg acaccctgct gctctgggtc ctcctgctgt gggtgcctgg cagcacagga 60
caggtgcaac tggtgcagag cggcgccgag gtcaagaaac ctggcgccac cgtgaagatc 120
agctgcaagg tgtccggctt caacatcaag gacacctaca tccactgggt ccaacaagcc 180
cccggaaagg gcctggaatg gatgggccgg attgaccccg ccaacgacaa caccctctat 240
gccagcaagt tccagggcag ggtcaccatc accgccgaca ccagcaccga caccgcctac 300
atggagctga gcagcctgcg gagcgaagac accgccgtgt actactgcgc caggggctac 360
ggctactacg tcttcgacca ttggggacag ggcaccctcg tgacagtgtc cagcggagga 420
ggatccggcg gaggaggaga tatccagatg acccagagcc cttccagcct gtccgcttcc 480
gtgggagatc gggtgaccat cacatgcagg acctccaggt ccatctccca gtacctggcc 540
tggtaccaac agaagcccgg caaggtgccc aagctgctga tctacagcgg cagcacactg 600
caatccggcg tcccttcccg gttttccgga tccggatccg gcaccgactt caccctgacc 660
atcagctccc tgcaacccga ggacgtggcc acctactact gtcagcagca caacgagaac 720
cccctcacct ttggcggcgg aaccaaggtc gagatcaagg gcggctgc              768

<210> 26
<211> 321
<212> DNA
<213> Murine

<400> 26
gatgtccaga taaaccagtc tccatctttt cttgctgcgt ctcctggaga aaccattact 60
ataaattgca ggacaagtag gagtattagt caatatttag cctggtatca agagaaacct 120
gggaaaacta ataagcttct tatctactct ggatccactc tgcaatctgg aattccatca 180
aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtgg cctggagcct 240
gaagattttg caatgtatta ctgtcaacag cataatgaaa acccgctcac gttcggtgct 300
gggaccaagc tggagctgaa g                                           321

<210> 27
<211> 107
<212> PRT
<213> Murine

<400> 27
Asp Val Gln Ile Asn Gln Ser Pro Ser Phe Leu Ala Ala Ser Pro Gly
 1               5                  10                  15      
Glu Thr Ile Thr Ile Asn Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 28
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 28
gacgtccaga taacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca ggacaagtag gagtattagt caatatttag cctggtatca gcagaaacca 120
gggaaagttc ctaagctcct gatctattct ggatccactc tgcaatctgg agtcccatct 180
cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagatgttg caacttatta ctgtcaacag cataatgaaa acccgctcac gttcggcgga 300
gggaccaagg tggagatcaa a                                           321

<210> 29
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 29
Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 30
<211> 354
<212> DNA
<213> Murine

<400> 30
gaggtccagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg 60
tcctgcacag cttctggctt caacattaaa gacacctata tacacttcgt gaggcagagg 120
cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatgataa tactttatat 180
gcctcaaagt tccagggcaa ggccactata acagcagaca catcatccaa cacagcctac 240
atgcacctct gcagcctgac atctggggac actgccgtct attactgtgg tagaggttat 300
ggttactacg tatttgacca ctggggccaa ggcaccactc tcacagtctc ctca       354

<210> 31
<211> 118
<212> PRT
<213> Murine

<400> 31
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met His Leu Cys Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 32
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 32
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg 60
agctgcgcgg cgagcggctt taacattaaa gatacctata ttcattttgt gcgccaggcg 120
ccgggcaaag gcctggaatg gattggccgc attgatccgg cgaacgataa caccctgtat 180
gcgagcaaat ttcagggcaa agcgaccatt agcgcggata ccagcaaaaa caccgcgtat 240
ctgcagatga acagcctgcg cgcgggagat accgcggtgt attattgcgg ccgcggctat 300
ggctattatg tgtttgatca ttggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 33
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 34
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 34
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg 60
agctgcgcgg cgagcggctt taacattaaa gatacctata ttcattttgt gcgccaggcg 120
ccgggcaaag gcctggaatg gattggccgc attgatccgg cgaacgataa caccctgtat 180
gcgagcaaat ttcagggcaa agcgaccatt agcgcggata ccagcaaaaa caccgcgtat 240
ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgg ccgcggctat 300
ggctattatg tgtttgatca ttggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 35
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 36
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 36
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgac cgtgaaaatt 60
agctgcaaag tgagcggctt taacattaaa gatacctata ttcattttgt gcagcaggcg 120
ccgggcaaag gcctggaatg gattggccgc attgatccgg cgaacgataa caccctgtat 180
gcgagcaaat ttcagggcaa agcgaccatt accgcggata ccagcaccga taccgcgtat 240
atggaactga gcagcctgcg cagcggagat accgcggtgt attattgcgg ccgcggctat 300
ggctattatg tgtttgatca ttggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 37
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 37
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Gly Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 38
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 38
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgac cgtgaaaatt 60
agctgcaaag tgagcggctt taacattaaa gatacctata ttcattttgt gcagcaggcg 120
ccgggcaaag gcctggaatg gattggccgc attgatccgg cgaacgataa caccctgtat 180
gcgagcaaat ttcagggcaa agcgaccatt accgcggata ccagcaccga taccgcgtat 240
atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgg ccgcggctat 300
ggctattatg tgtttgatca ttggggccag ggcaccctgg tgaccgtgag cagc       354

<210> 39
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or fragment thereof

<400> 39
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser
        115         


<210> 40
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence

<400> 40
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser Ser
        


<210> 41
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M variable heavy sequence

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 42
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 EH1

<400> 42
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 43
<211> 9
<212> PRT
<213> Homo sapiens

<400> 43
Cys Cys Val Glu Cys Pro Pro Cys Pro
 1               5                  


<210> 44
<211> 10
<212> PRT
<213> Homo sapiens

<400> 44
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
 1               5                  10  


<210> 45
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 CH3

<400> 45
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 46
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 EH2

<400> 46
Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 47
<211> 9
<212> PRT
<213> Homo sapiens

<400> 47
Ser Cys Val Glu Cys Pro Pro Cys Pro
 1               5                  


<210> 48
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH1

<400> 48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
 1               5                  10                  15      
Gly Ser Ser Gly Gly Gly Ser Gly
            20                  


<210> 49
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge
      

<400> 49
Glu Pro Lys Ser Cys Asp Lys Thr His Thr
 1               5                  10  


<210> 50
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 CH3 (G1m1 allotype)

<400> 50
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
 1               5                  10                  15      
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 51
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 CH3 (nG1m1 allotype)

<400> 51
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            100                 105         


<210> 52
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 NH1

<400> 52
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro
            


<210> 53
<211> 7
<212> PRT
<213> Homo sapiens

<400> 53
Ala Pro Pro Val Ala Gly Pro
 1               5          


<210> 54
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 NH2

<400> 54
Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro
            


<210> 55
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH3

<400> 55
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25          


<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 56
Glu Pro Lys Ser Ser Asp Lys Thr His Thr
 1               5                  10  


<210> 57
<211> 7
<212> PRT
<213> Homo sapiens

<400> 57
Cys Pro Pro Cys Pro Pro Cys
 1               5          


<210> 58
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH5

<400> 58
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  30  


<210> 59
<211> 10
<212> PRT
<213> Homo sapiens

<400> 59
Cys Pro Pro Cys Pro Pro Cys Pro Pro Cys
 1               5                  10  


<210> 60
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH6

<400> 60
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Val Glu Cys
 1               5                  10                  15      
Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  


<210> 61
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 61
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr
 1               5                  10          


<210> 62
<211> 7
<212> PRT
<213> Homo sapiens

<400> 62
Cys Val Glu Cys Pro Pro Cys
 1               5          


<210> 63
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH7

<400> 63
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15      
Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  


<210> 64
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH8

<400> 64
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15      
Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  30          


<210> 65
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH2

<400> 65
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
 1               5                  10                  15      
Gly Ser Ser Gly Gly Gly Ser Gly
            20                  


<210> 66
<211> 396
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH3(Minibody 1)

<400> 66
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly
        275                 280                 285             
Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
    290                 295                 300                 
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
305                 310                 315                 320 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
                325                 330                 335     
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
            340                 345                 350         
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
        355                 360                 365             
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
    370                 375                 380                 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
385                 390                 395     


<210> 67
<211> 1191
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH3(M1)

<400> 67
atggagaccg ataccctgct gctgtgggtg ctgctgctgt gggtgcccgg ctccacaggc 60
gatgtgcaga tcacacagag ccctagcagc ctgagcgcca gcgtgggaga tagagtcacc 120
atcacatgca ggaccagcag aagcattagc cagtacctgg cctggtacca gcaaaagccc 180
ggcaaggtgc ccaagctgct gatctacagc ggctccaccc tgcagagcgg cgtgcccagc 240
agattctccg gctccggaag cggcacagac tttaccctga ccatctcctc cctgcagccc 300
gaggatgtcg ccacctacta ctgccagcag cacaacgaaa accccctgac atttggcggc 360
ggcaccaagg tggagatcaa gggcagcacc agcggtggag gaagtggagg tggaagtgga 420
ggaggcggaa gcagcgaggt gcagctggtg gagagtggtg gaggactggt gcagcccgga 480
ggcagcctga gactgagctg tgctgcctcc ggattcaata tcaaggacac ctacatccac 540
ttcgtgagac aggcccccgg caagggactg gagtggattg gaaggatcga ccccgccaac 600
gacaacaccc tgtacgccag caaattccag ggcaaggcca caatcagcgc cgacaccagc 660
aagaacaccg cctatctgca gatgaactcc ctgagagccg aggacacagc cgtgtactac 720
tgcggcaggg gctacggcta ttacgtgttc gaccactggg gccagggcac cctggtgaca 780
gtgagcagcg aacccaagag ctccgacaag acccacacct gtcccccttg ccctccttgt 840
ggcggaggaa gctccggagg cggaagcgga ggacagccta gggagcccca ggtgtatacc 900
ctccccccct ccagggaaga gatgaccaag aaccaggtga gcctgacctg cctcgtgaag 960
ggcttttatc cctccgatat cgccgtggag tgggagagca acggccagcc tgagaacaat 1020
tacaagacca ccccccctgt gctggactcc gatggcagct tcttcctgta ttccaagctg 1080
accgtcgaca agtccaggtg gcaacagggc aacgtcttca gctgcagcgt gatgcacgag 1140
gccctgcaca atcactacac ccagaagtcc ctctccctga gccccggctg a          1191

<210> 68
<211> 1200
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH5(M1)

<400> 68
atggagacag acaccctcct cctgtgggtg ctgctgctgt gggtgcccgg atccaccgga 60
gacgtgcaga tcacacagag ccccagctcc ctgtccgcta gcgtgggcga cagagtgacc 120
atcacctgca ggaccagcag gagcatctcc cagtacctcg cttggtacca gcagaagcct 180
ggcaaggtgc ccaagctgct gatttacagc ggatccaccc tgcagagcgg cgtgcctagc 240
aggtttagcg gcagcggatc cggaacagac ttcaccctga ccatcagcag cctgcagcct 300
gaagatgtgg ccacctacta ctgtcagcag cacaacgaaa accccctcac cttcggcggc 360
ggcacaaagg tggaaatcaa gggcagcacc tccggaggag gcagcggcgg aggcagcgga 420
ggcggcggct ccagcgaagt gcagctggtc gagagcggag gcggactggt gcaacccgga 480
ggaagcctga ggctgagctg tgccgccagc ggcttcaaca tcaaggacac atacattcac 540
tttgtgaggc aggctcctgg aaagggcctg gagtggatcg gcagaatcga ccccgctaac 600
gacaacaccc tgtacgccag caagttccag ggcaaggcca ccatctccgc cgacacaagc 660
aagaataccg cctacctgca gatgaactcc ctgagggccg aggataccgc cgtgtactac 720
tgcggcaggg gctatggcta ctacgtgttt gaccactggg gccagggcac actggtgaca 780
gtgagctccg agcccaagag ctccgacaag acacacacct gccctccttg ccccccttgt 840
cctccctgtg gaggaggaag cagcggagga ggaagcggcg gacagcccag agagcctcaa 900
gtgtataccc tgcccccctc cagggaagag atgaccaaga accaggtgag cctgacatgc 960
ctggtcaaag gcttctaccc cagcgatatt gctgtggagt gggagagcaa cggccagccc 1020
gagaacaact acaagaccac accccccgtc ctggatagcg atggcagctt cttcctgtac 1080
agcaagctga ccgtggacaa gtccaggtgg cagcagggca acgtcttctc ctgcagcgtg 1140
atgcacgagg ctctgcataa ccactacaca cagaagtccc tcagcctgag ccctggatga 1200


<210> 69
<211> 399
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH5(M1)

<400> 69
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser
        275                 280                 285             
Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
    290                 295                 300                 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
305                 310                 315                 320 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                325                 330                 335     
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
            340                 345                 350         
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
        355                 360                 365             
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
    370                 375                 380                 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
385                 390                 395                 


<210> 70
<211> 398
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH7(Minibody 1)

<400> 70
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr
            260                 265                 270         
Thr His Thr Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly
        275                 280                 285             
Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
    290                 295                 300                 
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
305                 310                 315                 320 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
                325                 330                 335     
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
            340                 345                 350         
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
        355                 360                 365             
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
    370                 375                 380                 
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
385                 390                 395             


<210> 71
<211> 1197
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH7(Minibody 1)

<400> 71
atggagacag acaccctcct cctgtgggtg ctgctgctgt gggtgcccgg atccaccgga 60
gacgtgcaga tcacacagag ccccagctcc ctgtccgcta gcgtgggcga cagagtgacc 120
atcacctgca ggaccagcag gagcatctcc cagtacctcg cttggtacca gcagaagcct 180
ggcaaggtgc ccaagctgct gatttacagc ggatccaccc tgcagagcgg cgtgcctagc 240
aggtttagcg gcagcggatc cggaacagac ttcaccctga ccatcagcag cctgcagcct 300
gaagatgtgg ccacctacta ctgtcagcag cacaacgaaa accccctcac cttcggcggc 360
ggcacaaagg tggaaatcaa gggcagcacc tccggaggag gcagcggcgg aggcagcgga 420
ggcggcggct ccagcgaagt gcagctggtc gagagcggag gcggactggt gcaacccgga 480
ggaagcctga ggctgagctg tgccgccagc ggcttcaaca tcaaggacac atacattcac 540
tttgtgaggc aggctcctgg aaagggcctg gagtggatcg gcagaatcga ccccgctaac 600
gacaacaccc tgtacgccag caagttccag ggcaaggcca ccatctccgc cgacacaagc 660
aagaataccg cctacctgca gatgaactcc ctgagggccg aggataccgc cgtgtactac 720
tgcggcaggg gctatggcta ctacgtgttt gaccactggg gccagggcac actggtgaca 780
gtgagctccg agctgaagac acctctgggc gacacaacac acacctgccc cccttgtcct 840
ccctgtggag gaggaagcag cggaggagga agcggcggac agcccagaga gcctcaagtg 900
tataccctgc ccccctccag ggaagagatg accaagaacc aggtgagcct gacatgcctg 960
gtcaaaggct tctaccccag cgatattgct gtggagtggg agagcaacgg ccagcccgag 1020
aacaactaca agaccacacc ccccgtcctg gatagcgatg gcagcttctt cctgtacagc 1080
aagctgaccg tggacaagtc caggtggcag cagggcaacg tcttctcctg cagcgtgatg 1140
cacgaggctc tgcataacca ctacacacag aagtccctca gcctgagccc tggatga    1197

<210> 72
<211> 401
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH8(Minibody 1)

<400> 72
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Leu Lys Thr Pro Leu Gly Asp Thr
            260                 265                 270         
Thr His Thr Cys Pro Pro Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly
        275                 280                 285             
Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr
    290                 295                 300                 
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
305                 310                 315                 320 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
                325                 330                 335     
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
            340                 345                 350         
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
        355                 360                 365             
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
    370                 375                 380                 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
385                 390                 395                 400 
Gly
    


<210> 73
<211> 1206
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 1 EH8(Minibody 1)

<400> 73
atggagacag acaccctcct cctgtgggtg ctgctgctgt gggtgcccgg atccaccgga 60
gacgtgcaga tcacacagag ccccagctcc ctgtccgcta gcgtgggcga cagagtgacc 120
atcacctgca ggaccagcag gagcatctcc cagtacctcg cttggtacca gcagaagcct 180
ggcaaggtgc ccaagctgct gatttacagc ggatccaccc tgcagagcgg cgtgcctagc 240
aggtttagcg gcagcggatc cggaacagac ttcaccctga ccatcagcag cctgcagcct 300
gaagatgtgg ccacctacta ctgtcagcag cacaacgaaa accccctcac cttcggcggc 360
ggcacaaagg tggaaatcaa gggcagcacc tccggaggag gcagcggcgg aggcagcgga 420
ggcggcggct ccagcgaagt gcagctggtc gagagcggag gcggactggt gcaacccgga 480
ggaagcctga ggctgagctg tgccgccagc ggcttcaaca tcaaggacac atacattcac 540
tttgtgaggc aggctcctgg aaagggcctg gagtggatcg gcagaatcga ccccgctaac 600
gacaacaccc tgtacgccag caagttccag ggcaaggcca ccatctccgc cgacacaagc 660
aagaataccg cctacctgca gatgaactcc ctgagggccg aggataccgc cgtgtactac 720
tgcggcaggg gctatggcta ctacgtgttt gaccactggg gccagggcac actggtgaca 780
gtgagctccg agctgaagac acctctgggc gacacaacac acacctgccc tccttgcccc 840
ccttgtcctc cctgtggagg aggaagcagc ggaggaggaa gcggcggaca gcccagagag 900
cctcaagtgt ataccctgcc cccctccagg gaagagatga ccaagaacca ggtgagcctg 960
acatgcctgg tcaaaggctt ctaccccagc gatattgctg tggagtggga gagcaacggc 1020
cagcccgaga acaactacaa gaccacaccc cccgtcctgg atagcgatgg cagcttcttc 1080
ctgtacagca agctgaccgt ggacaagtcc aggtggcagc agggcaacgt cttctcctgc 1140
agcgtgatgc acgaggctct gcataaccac tacacacaga agtccctcag cctgagccct 1200
ggatga                                                            1206

<210> 74
<211> 391
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 2 EH2(Minibody 1)

<400> 74
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Arg Lys Ser Cys Val Glu Cys Pro
            260                 265                 270         
Pro Cys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro
        275                 280                 285             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
    290                 295                 300                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
305                 310                 315                 320 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                325                 330                 335     
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            340                 345                 350         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        355                 360                 365             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    370                 375                 380                 
Ser Leu Ser Leu Ser Pro Gly
385                 390     


<210> 75
<211> 1236
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 2 EH2(Minibody 1)

<400> 75
atggaaaccg acacactgct gctgtgggtg ctgctgctgt gggtccctgg ctccaccgga 60
gacgtccaga tcacacagag ccccagcagc ctgtccgcca gcgtgggaga cagggtgacc 120
gacgtccaga tcacacagag ccccagcagc ctgtccgcca gcgtgggaga cagggtgacc 180
gacgtccaga tcacacagag ccccagcagc ctgtccgcca gcgtgggaga cagggtgacc 240
ggcaaggtcc ccaaactgct gatctacagc ggctccaccc tgcagtccgg cgtgcctagc 300
aggttctccg gcagcggatc cggcaccgac ttcaccctga ccatcagctc cctgcagcct 360
gaggacgtgg ctacctacta ctgccaacag cacaacgaga accccctgac ctttggaggc 420
ggcaccaagg tggaaatcaa gggcagcacc agcggcggag gaagcggagg aggatccgga 480
ggaggcggaa gctccgaggt gcagctggtg gaaagcggcg gcggactggt gcagcctgga 540
ggaagcctca gactgagctg tgccgccagc ggattcaaca tcaaagacac ctacattcat 600
ttcgtgagac aggcccccgg caagggcctc gaatggatcg gaaggatcga ccccgctaac 660
gacaataccc tgtacgcctc caagttccag ggaaaggcca ccatctccgc cgatacctcc 720
aagaacaccg cctacctcca gatgaactcc ctgagggccg aagataccgc cgtctactac 780
tgtggcaggg gctacggcta ctatgtgttc gatcactggg gccaaggaac cctggtgacc 840
gtgagcagcg aaaggaagag ctgcgtggag tgtcctcctt gtcccggcgg cggctccagc 900
ggcggaggct ccggcggcca gcctagagaa cctcaggtgt acaccctccc cccctccaga 960
gaggagatga ccaagaacca ggtgtccctg acctgcctgg tgaaaggctt ctatcccagc 1020
gacatcgccg tggaatggga gtccaacggc cagcccgaga acaactacaa gaccacccct 1080
cccatgctgg attccgacgg cagctttttc ctgtacagca agctcaccgt ggacaagagc 1140
agatggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggctct gcataaccac 1200
tacacccaga agagcctgtc cctgtccccc ggatga                           1236

<210> 76
<211> 391
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 2 EH2(Minibody 1)(VH-K67R)

<400> 76
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser
        35                  40                  45              
Ile Ser Gln Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn
            100                 105                 110         
Glu Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly
        115                 120                 125             
Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                165                 170                 175     
Thr Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Ile Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys
        195                 200                 205             
Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
    210                 215                 220                 
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
225                 230                 235                 240 
Cys Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly
                245                 250                 255     
Thr Leu Val Thr Val Ser Ser Glu Arg Lys Ser Cys Val Glu Cys Pro
            260                 265                 270         
Pro Cys Pro Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro
        275                 280                 285             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
    290                 295                 300                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
305                 310                 315                 320 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                325                 330                 335     
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            340                 345                 350         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        355                 360                 365             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    370                 375                 380                 
Ser Leu Ser Leu Ser Pro Gly
385                 390     


<210> 77
<211> 1176
<212> DNA
<213> Artificial Sequence

<220> 
<223> IAB22M gamma 2 EH2(Minibody 1)

<400> 77
atggagaccg acaccctcct cctgtgggtg ctgctgctgt gggtgcctgg aagcaccggc 60
gatgtgcaga tcacccagag ccctagcagc ctgtccgctt ccgtgggcga cagggtgacc 120
atcacctgta ggacctccag gagcatctcc cagtacctgg cctggtacca gcagaagccc 180
ggcaaggtgc ccaaactgct catctactcc ggcagcacac tccagagcgg cgtccctagc 240
agattcagcg gaagcggcag cggcaccgac ttcaccctga ccatcagctc cctgcagccc 300
gaggacgtgg ccacctatta ctgtcagcag cacaacgaaa accccctgac cttcggcggc 360
ggcacaaaag tggagatcaa gggcagcacc agcggaggcg gatccggcgg cggcagcggc 420
ggcggaggat ccagcgaagt gcagctggtc gaaagcggag gcggactggt gcagcctgga 480
ggaagcctga gactcagctg cgccgcctcc ggattcaaca tcaaggacac ctacatccac 540
ttcgtgaggc aggctcccgg caaaggcctc gagtggattg gaaggattga ccccgccaac 600
gacaacaccc tgtacgccag caagttccaa ggaagggcca ccatctccgc cgacaccagc 660
aagaataccg cctacctgca gatgaactcc ctgagggctg aggacaccgc cgtgtactac 720
tgcggcagag gctacggcta ctacgtgttc gaccactggg gacagggcac actggtgaca 780
gtgagcagcg agaggaaaag ctgcgtggag tgccccccct gccctggcgg cggcagctcc 840
ggcggaggaa gcggaggaca acccagggag ccccaggtgt acacactccc ccctagcagg 900
gaagagatga ccaagaacca ggtgtccctg acctgcctcg tgaagggatt ctaccccagc 960
gacattgccg tcgagtggga gagcaacggc cagcctgaga acaactacaa gacaaccccc 1020
cctatgctcg atagcgatgg ctccttcttc ctgtactcca agctcaccgt cgacaagagc 1080
aggtggcagc agggcaacgt cttctcctgt agcgtgatgc acgaggctct gcacaaccac 1140
tacacccaga agagcctgag cctgagcccc ggctga                           1176

<210> 78
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22M variable heavy (VH-K67R) sequence

<400> 78
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
            20                  25                  30          
Tyr Ile His Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe
    50                  55                  60                  
Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Gly Arg Gly Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 79
<211> 376
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB22 (CD8)

<400> 79
Asp Val Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Arg Ser Ile Ser Gln Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Asn Glu Asn Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln
        115                 120                 125             
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg
    130                 135                 140                 
Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His
145                 150                 155                 160 
Phe Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Arg Ile
                165                 170                 175     
Asp Pro Ala Asn Asp Asn Thr Leu Tyr Ala Ser Lys Phe Gln Gly Lys
            180                 185                 190         
Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met
        195                 200                 205             
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly
    210                 215                 220                 
Tyr Gly Tyr Tyr Val Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr
225                 230                 235                 240 
Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
                245                 250                 255     
Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln
            260                 265                 270         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        275                 280                 285             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    290                 295                 300                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
305                 310                 315                 320 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                325                 330                 335     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            340                 345                 350         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        355                 360                 365             
Lys Ser Leu Ser Leu Ser Pro Gly
    370                 375     


<210> 80
<211> 235
<212> PRT
<213> Homo sapiens

<400> 80
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr
            20                  25                  30          
Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser
        35                  40                  45              
Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala
    50                  55                  60                  
Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala
65                  70                  75                  80  
Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp
                85                  90                  95      
Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr
            100                 105                 110         
Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe
        115                 120                 125             
Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
    130                 135                 140                 
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
145                 150                 155                 160 
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
                165                 170                 175     
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
            180                 185                 190         
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
        195                 200                 205             
Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser
    210                 215                 220                 
Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val
225                 230                 235 


<210> 81
<211> 235
<212> PRT
<213> Homo sapiens

<400> 81
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr
            20                  25                  30          
Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser
        35                  40                  45              
Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala
    50                  55                  60                  
Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala
65                  70                  75                  80  
Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp
                85                  90                  95      
Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr
            100                 105                 110         
Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe
        115                 120                 125             
Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
    130                 135                 140                 
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
145                 150                 155                 160 
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
                165                 170                 175     
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
            180                 185                 190         
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
        195                 200                 205             
Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser
    210                 215                 220                 
Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val
225                 230                 235 


<210> 82
<211> 210
<212> PRT
<213> Homo sapiens

<400> 82
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu
 1               5                  10                  15      
His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln
            20                  25                  30          
Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser
        35                  40                  45              
Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp
    50                  55                  60                  
Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile
65                  70                  75                  80  
His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala
                85                  90                  95      
Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly
            100                 105                 110         
Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys
        115                 120                 125             
Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro
    130                 135                 140                 
Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro
145                 150                 155                 160 
Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Val Thr Leu Gly Leu Leu
                165                 170                 175     
Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Met His
            180                 185                 190         
Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe
        195                 200                 205             
Tyr Lys
    210 


<210> 83
<211> 56
<212> PRT
<213> Artificial Sequence

<220> 
<223> MAX16H5

<400> 83
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Gln Trp Ile
        35                  40                  45              
Gly Ala Leu Tyr Pro Gly Asn Val
    50                  55      


<210> 84
<211> 56
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB41

<400> 84
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Leu Tyr Pro Gly Asn Val
    50                  55      


<210> 85
<211> 58
<212> PRT
<213> Artificial Sequence

<220> 
<223> MAX16H5

<400> 85
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro
    50                  55              


<210> 86
<211> 58
<212> PRT
<213> Artificial Sequence

<220> 
<223> IAB41

<400> 86
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro
    50                  55              


<210> 87
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> signal peptide

<400> 87
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly
            20  


<210> 88
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> minibody

<400> 88
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu
65                  70                  75                  80  
Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Gly
            100                 105                 110         
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Val Gln Leu
        115                 120                 125             
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val
    130                 135                 140                 
Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp Met His Trp
145                 150                 155                 160 
Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly Ala Leu Tyr
                165                 170                 175     
Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln Gly Arg Val
            180                 185                 190         
Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser
        195                 200                 205             
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Met Gly
    210                 215                 220                 
Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
225                 230                 235                 240 
Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro
                245                 250                 255     
Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
            260                 265                 270         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
        275                 280                 285             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    290                 295                 300                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
305                 310                 315                 320 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                325                 330                 335     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            340                 345                 350         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        355                 360                 365             
Gln Lys Ser Leu Ser Leu Ser Pro Gly
    370                 375         


<210> 89
<211> 380
<212> PRT
<213> Artificial Sequence

<220> 
<223> minibody

<400> 89
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu
65                  70                  75                  80  
Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Gly
            100                 105                 110         
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Val Gln Leu
        115                 120                 125             
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val
    130                 135                 140                 
Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp Met His Trp
145                 150                 155                 160 
Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly Ala Leu Tyr
                165                 170                 175     
Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln Gly Arg Val
            180                 185                 190         
Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser
        195                 200                 205             
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Met Gly
    210                 215                 220                 
Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
225                 230                 235                 240 
Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro
                245                 250                 255     
Pro Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly
            260                 265                 270         
Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
        275                 280                 285             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
    290                 295                 300                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
305                 310                 315                 320 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
                325                 330                 335     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
            340                 345                 350         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
        355                 360                 365             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
    370                 375                 380 


<210> 90
<211> 377
<212> PRT
<213> Artificial Sequence

<220> 
<223> minibody

<400> 90
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val Leu Thr Gln
    130                 135                 140                 
Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser
145                 150                 155                 160 
Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr Gln Gln Lys
                165                 170                 175     
Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala
            180                 185                 190         
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
        195                 200                 205             
Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala Val Tyr Tyr
    210                 215                 220                 
Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys
225                 230                 235                 240 
Leu Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro
                245                 250                 255     
Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
            260                 265                 270         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
        275                 280                 285             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    290                 295                 300                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
305                 310                 315                 320 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                325                 330                 335     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            340                 345                 350         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        355                 360                 365             
Gln Lys Ser Leu Ser Leu Ser Pro Gly
    370                 375         


<210> 91
<211> 380
<212> PRT
<213> Artificial Sequence

<220> 
<223> minibody

<400> 91
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val Leu Thr Gln
    130                 135                 140                 
Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser
145                 150                 155                 160 
Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr Gln Gln Lys
                165                 170                 175     
Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala
            180                 185                 190         
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
        195                 200                 205             
Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala Val Tyr Tyr
    210                 215                 220                 
Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys
225                 230                 235                 240 
Leu Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro
                245                 250                 255     
Pro Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly
            260                 265                 270         
Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
        275                 280                 285             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
    290                 295                 300                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
305                 310                 315                 320 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
                325                 330                 335     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
            340                 345                 350         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
        355                 360                 365             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
    370                 375                 380 


<210> 92
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cys-Diabody

<400> 92
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu
65                  70                  75                  80  
Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Gln
            100                 105                 110         
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser
        115                 120                 125             
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp
    130                 135                 140                 
Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly
145                 150                 155                 160 
Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln
                165                 170                 175     
Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met
            180                 185                 190         
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
        195                 200                 205             
Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly
    210                 215                 220                 
Thr Leu Val Thr Val Ser Ser Gly Gly Cys
225                 230                 


<210> 93
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> cys-diabody

<400> 93
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu
65                  70                  75                  80  
Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Gln
            100                 105                 110         
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser
        115                 120                 125             
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp
    130                 135                 140                 
Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly
145                 150                 155                 160 
Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln
                165                 170                 175     
Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met
            180                 185                 190         
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
        195                 200                 205             
Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly
    210                 215                 220                 
Thr Leu Val Thr Val Ser Ser Gly Gly Cys Pro Pro Cys
225                 230                 235         


<210> 94
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> cys-diabody

<400> 94
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu
65                  70                  75                  80  
Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Gln
            100                 105                 110         
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser
        115                 120                 125             
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp
    130                 135                 140                 
Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly
145                 150                 155                 160 
Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln
                165                 170                 175     
Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met
            180                 185                 190         
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
        195                 200                 205             
Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly
    210                 215                 220                 
Thr Leu Val Thr Val Ser Ser Gly Gly Cys Pro Pro Cys Pro Pro Cys
225                 230                 235                 240 


<210> 95
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> cys-diabody

<400> 95
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu
65                  70                  75                  80  
Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Gln
            100                 105                 110         
Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser
        115                 120                 125             
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp
    130                 135                 140                 
Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly
145                 150                 155                 160 
Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln
                165                 170                 175     
Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met
            180                 185                 190         
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
        195                 200                 205             
Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly
    210                 215                 220                 
Thr Leu Val Thr Val Ser Ser Gly Gly Cys Pro Pro Cys Pro Pro Cys
225                 230                 235                 240 
Pro Pro Cys
            


<210> 96
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> cys-diabody

<400> 96
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu Ile Val
        115                 120                 125             
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
    130                 135                 140                 
Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr
145                 150                 155                 160 
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser
                165                 170                 175     
Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly
            180                 185                 190         
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala
        195                 200                 205             
Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly
    210                 215                 220                 
Gly Thr Lys Leu Glu Ile Lys Gly Gly Cys
225                 230                 


<210> 97
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> cys-diabody

<400> 97
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu Ile Val
        115                 120                 125             
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
    130                 135                 140                 
Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr
145                 150                 155                 160 
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser
                165                 170                 175     
Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly
            180                 185                 190         
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala
        195                 200                 205             
Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly
    210                 215                 220                 
Gly Thr Lys Leu Glu Ile Lys Gly Gly Cys Pro Pro Cys
225                 230                 235         


<210> 98
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> cys-diabody

<400> 98
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu Ile Val
        115                 120                 125             
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
    130                 135                 140                 
Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr
145                 150                 155                 160 
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser
                165                 170                 175     
Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly
            180                 185                 190         
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala
        195                 200                 205             
Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly
    210                 215                 220                 
Gly Thr Lys Leu Glu Ile Lys Gly Gly Cys Pro Pro Cys Pro Pro Cys
225                 230                 235                 240 


<210> 99
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> cys-diabody

<400> 99
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu Ile Val
        115                 120                 125             
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
    130                 135                 140                 
Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr
145                 150                 155                 160 
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser
                165                 170                 175     
Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly
            180                 185                 190         
Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala
        195                 200                 205             
Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly
    210                 215                 220                 
Gly Thr Lys Leu Glu Ile Lys Gly Gly Cys Pro Pro Cys Pro Pro Cys
225                 230                 235                 240 
Pro Pro Cys
            


<210> 100
<211> 433
<212> PRT
<213> Homo sapiens

<400> 100
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
 1               5                  10                  15      
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
            20                  25                  30          
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
        35                  40                  45              
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln
    50                  55                  60                  
Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
65                  70                  75                  80  
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
                85                  90                  95      
Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln
            100                 105                 110         
Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val
        115                 120                 125             
Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu
    130                 135                 140                 
Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr
145                 150                 155                 160 
Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val
                165                 170                 175     
Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu
            180                 185                 190         
Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr
        195                 200                 205             
Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys
    210                 215                 220                 
Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg
225                 230                 235                 240 
Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His
                245                 250                 255     
Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu
            260                 265                 270         
Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn
        275                 280                 285             
Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu
    290                 295                 300                 
Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu
305                 310                 315                 320 
Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu
                325                 330                 335     
Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln
            340                 345                 350         
Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro
        355                 360                 365             
Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu
    370                 375                 380                 
Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg
385                 390                 395                 400 
Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu
                405                 410                 415     
Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro
            420                 425                 430         
Ile
    


<210> 101
<211> 106
<212> PRT
<213> Mus musculus

<400> 101
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn
            100                 105     


<210> 102
<211> 108
<212> PRT
<213> Homo sapiens

<400> 102
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro
                85                  90                  95      
Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 103
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 103
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105     


<210> 104
<211> 119
<212> PRT
<213> Mus musculus

<400> 104
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 105
<211> 115
<212> PRT
<213> Homo sapiens

<400> 105
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 106
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 106
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 107
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 107
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser
            20                  25                  30          
Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly
                85                  90                  95      
Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Ser
        115                 120                 125             
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
    130                 135                 140                 
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
145                 150                 155                 160 
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                165                 170                 175     
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
            180                 185                 190         
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
        195                 200                 205             
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
    210                 215                 220                 
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Thr Leu Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 108
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 108
atggaaaccg acactctgct gctgtgggtc ctgctgctgt gggtgcccgg atcaactgga 60
cagatcgtgc tgactcagtc tcccgctatc atgtctgcct cacctggcga aaaagtgaca 120
atgacctgtt ccgcctcttc ttccgtgtct tacatgaatt ggtaccagca gaaatctggg 180
actagtccta aacggtggat ctacgatact agcaaactgg cttctggcgt gcctgctcat 240
ttccgtggtt ctggctctgg aacctcttac tctctgacca tctctggcat ggaggccgag 300
gatgccgcca cctactactg ccagcagtgg agttcaaacc ctttcacatt cggctccggc 360
acaaaactgg agatcaacgg ctctactagt ggtggaggat ctggtggtgg atctggaggg 420
ggcggatcat ctcaggtcca gctgcagcag tctggtgctg aactggcacg tcctggtgcc 480
tccgtgaaaa tgtcttgtaa ggcctctggt tacaccttta cccggtacac tatgcattgg 540
gtcaaacagc gccctgggca gggactggaa tggattggct acatcaaccc ttctcgtggc 600
tacacaaact acaatcagaa attcaaggac aaggccaccc tgacaaccga caaatcttct 660
tcaaccgcct acatgcagct gtcatccctg acctctgagg atagtgctgt gtactactgt 720
gctcggtact acgacgatca ctactgtctg gactactggg gacagggaac aacactgact 780
gtgtcctccg aacccaaatc ctgtgacaaa acccacacct gtccaccttg tggcggtgga 840
tcatctggcg gagggagtgg agggcagcct agggagcctc aggtctacac actgccacct 900
tctcgggacg aactgacaaa aaaccaggtg tccctgacat gtctggtgaa gggcttctac 960
ccttccgata tcgctgtgga gtgggagtca aatggccagc ccgaaaacaa ctacaaaacc 1020
accccacctg tgctggattc cgatggctct ttcttcctgt actctaaact gaccgtggat 1080
aagagtcgat ggcagcaggg aaacgtgttc tcttgctccg tgatgcacga ggccctgcat 1140
aatcattaca cccagaaatc actgtctctg tcacccggca aatga                 1185

<210> 109
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 109
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Ser
        115                 120                 125             
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
    130                 135                 140                 
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                165                 170                 175     
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
            180                 185                 190         
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
        195                 200                 205             
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
    210                 215                 220                 
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
225                 230                 235                 240 
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Pro Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 110
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 110
atggaaaccg acactctgct gctgtgggtc ctgctgctgt gggtgcccgg atcaactggt 60
gacatccaga tgacacagtc tccctcttct ctgtccgcct ctgtgggcga tcgagtgaca 120
atcacctgta gcgcttcatc ctccgtgtct tacatgaatt ggtaccagca gacccctggc 180
aaagctccta aacgatggat ctacgacacc tccaaactgg cttccggcgt gccttcacga 240
ttttctggtt ctggttctgg gaccgactac acctttacca tctcatcact gcagcctgag 300
gatatcgcca catactactg tcagcagtgg tctagcaacc ctttcacatt cgggcagggc 360
acaaaactgc agatcaccgg ctcaacctct ggcggtggct ctggcggcgg tagtggtggt 420
ggtggttcta gtcaggtcca gctggtccag tctggtggag gagtggtcca gcccgggaga 480
tcactgaggc tgtcctgtaa ggctagtggc tacactttta cacggtacac catgcattgg 540
gtgaggcagg cacctgggaa aggcctggaa tggatcggat acatcaaccc tagtagggga 600
tacacaaact acaatcagaa agtcaaggac cggttcacaa tctctaggga caactctaaa 660
aacaccgctt ttctgcagat ggactcactg aggcctgagg acactggagt gtacttttgt 720
gctcggtact acgatgatca ttactgcctg gattactggg gacaggggac acctgtcact 780
gtctcttccg aacccaaatc ttgtgacaaa acccacacat gccctccatg tggtggcgga 840
tcctctggtg gcggttctgg ggggcagcct agggaacctc aggtgtacac actgccacct 900
tctcgtgacg aactgaccaa aaaccaggtg tcactgacct gtctggtcaa gggcttttac 960
ccttccgaca ttgctgtgga gtgggagtca aatggccagc ctgaaaacaa ctacaaaacc 1020
acaccccccg tcctggattc cgatggctct ttcttcctgt actctaaact gaccgtcgac 1080
aaatctcgat ggcagcaggg aaacgtgttc tcttgttccg tcatgcacga ggctctgcac 1140
aatcactaca cacagaaatc actgagcctg agccctggaa aatga                 1185

<210> 111
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 111
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Ser
        115                 120                 125             
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
    130                 135                 140                 
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
                165                 170                 175     
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
            180                 185                 190         
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
        195                 200                 205             
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
    210                 215                 220                 
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
225                 230                 235                 240 
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Pro Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 112
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 112
atggaaaccg acactctgct gctgtgggtc ctgctgctgt gggtgcccgg atcaactggt 60
gacatccaga tgacacagtc tccctcttct ctgtccgcct ctgtgggcga tcgagtgaca 120
atcacctgta gcgcttcatc ctccgtgtct tacatgaatt ggtaccagca gacccctggc 180
aaagctccta aacgatggat ctacgacacc tccaaactgg cttccggcgt gccttcacga 240
ttttctggtt ctggttctgg gaccgactac acctttacca tctcatcact gcagcctgag 300
gatatcgcca catactactg tcagcagtgg tctagcaacc ctttcacatt cgggcagggc 360
acaaaactgc agatcaccgg ctcaacctct ggcggtggct ctggcggcgg tagtggtggt 420
ggtggttcta gtcaggtcca gctggtccag tctggtggag gagtggtcca gcccgggaga 480
tcactgaggc tgtcctgtaa ggctagtggc tacactttta cacggtacac catgcattgg 540
gtgaggcagg cacctgggaa aggcctggaa tggatcggat acatcaaccc tagtagggga 600
tacacaaact acaatcagaa agtcaaggac cggttcacaa tctctaggga caactctaaa 660
aacaccgctt ttctgcagat ggactcactg aggcctgagg acactggagt gtacttttgt 720
gctcggtact acgatgatca ttactgcctg gattactggg gacaggggac acctgtcact 780
gtctcttccg aacccaaatc ttgtgacaaa acccacacat gccctccatg tggtggcgga 840
tcctctggtg gcggttctgg ggggcagcct agggaacctc aggtgtacac actgccacct 900
tctcgtgacg aactgaccaa aaaccaggtg tcactgacct gtctggtcaa gggcttttac 960
ccttccgaca ttgctgtgga gtgggagtca aatggccagc ctgaaaacaa ctacaaaacc 1020
acaccccccg tcctggattc cgatggctct ttcttcctgt actctaaact gaccgtcgac 1080
aaatctcgat ggcagcaggg aaacgtgttc tcttgttccg tcatgcacga ggctctgcac 1140
aatcactaca cacagaaatc actgagcctg agccctggaa aatga                 1185

<210> 113
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 113
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
    50                  55                  60                  
Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
                85                  90                  95      
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly
        115                 120                 125             
Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145                 150                 155                 160 
Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
                165                 170                 175     
Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn
            180                 185                 190         
Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 114
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 114
atggaaaccg acactctgct gctgtgggtc ctgctgctgt gggtgcccgg atcaactgga 60
gaaatcgtgc tgactcagtc ccctgctaca ctgtctctgt cacctggcga acgagcaaca 120
ctgtcctgtt ctgcctcttc ttctgtctca tacatgaact ggtaccagca gaaacctgga 180
caggctccta gactgctgat ctacgacacc tctaaactgg catctggcgt gcccgctcat 240
tttcgtggct ctggatctgg aaccgacttt accctgacca tctcttccct ggaacctgag 300
gattttgccg tgtactactg ccagcagtgg tctagtaacc ctttcacttt tggccagggc 360
actaaagtgg agatcaaatc cggtggtggc ggacaggtcc agctggtcca gagtggagct 420
gaggtgaaaa aacccggcgc ttccgtcaaa gtctcctgta aggctagcgg atacacattc 480
acacgctaca ccatgcattg ggtccggcag gctcccggac agggcctgga atggatggga 540
tacatcaacc cttctcgggg ctacacaaac tacaaccaga aattcaagga tcgagtgacc 600
atgacaaccg acactagcat ctctaccgcc tacatggaac tgagccggct gagatccgat 660
gataccgctg tctactactg tgctcggtac tacgatgatc attactgcct ggattactgg 720
gggcagggca cactggtgac tgtgagttcc ggaggatgt                        759

<210> 115
<211> 435
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 115
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Met Asp Trp Val Trp Thr Leu Leu Phe Leu Leu Ser
            20                  25                  30          
Val Thr Ala Gly Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala
        35                  40                  45              
Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser
    50                  55                  60                  
Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro
65                  70                  75                  80  
Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr
                85                  90                  95      
Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp
            100                 105                 110         
Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu
        115                 120                 125             
Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys
    130                 135                 140                 
Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Ser
145                 150                 155                 160 
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
                165                 170                 175     
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser
            180                 185                 190         
Val Ile Ile Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile
        195                 200                 205             
Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser
    210                 215                 220                 
Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser
225                 230                 235                 240 
Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro
                245                 250                 255     
Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile
            260                 265                 270         
Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp
        275                 280                 285             
Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn
    290                 295                 300                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
305                 310                 315                 320 
Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val
                325                 330                 335     
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser
            340                 345                 350         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        355                 360                 365             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    370                 375                 380                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
385                 390                 395                 400 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                405                 410                 415     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            420                 425                 430         
Pro Gly Lys
        435 


<210> 116
<211> 1308
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 116
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
atggattggg tgtggacctt gctattcctg ttgtcagtaa ctgcaggtgt ccactcccag 120
gtccagctgc agcagtctgg ggctgaactg gcaagacctg gggcctcagt gaagatgtcc 180
tgcaaggctt ctggctacac ctttactagg tacacgatgc actgggtaaa acagaggcct 240
ggacagggtc tggaatggat tggatacatt aatcctagcc gtggttatac taattacaat 300
cagaagttca aggacaaggc cacattgact acagacaaat cctccagcac agcctacatg 360
caactgagca gcctgacatc tgaggactct gcagtctatt actgtgcaag atattatgat 420
gatcattact gccttgacta ctggggccaa ggcaccactc tcacagtctc ctcaggctcc 480
acatccggcg gaggctctgg cggtggatct ggcggaggcg gctcatccat ggattttcaa 540
gtgcagattt tcagcttcct gctaatcagt gcctcagtca taatatccag aggacaaatt 600
gttctcaccc agtctccagc aatcatgtct gcatctccag gggagaaggt caccatgacc 660
tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagtc aggcacctcc 720
cccaaaagat ggatttatga cacatccaaa ctggcttctg gagtccctgc tcacttcagg 780
ggcagtgggt ctgggacctc ttactctctc acaatcagcg gcatggaggc tgaagatgct 840
gccacttatt actgccagca gtggagtagt aacccattca cgttcggctc ggggacaaag 900
ttggaaataa acgagcctaa gtcctgcgac aagacccaca cctgtccccc ttgcggcgga 960
ggaagcagcg gaggcggatc cggtggccag cctcgggagc ctcaggtgta caccctgcct 1020
ccctcccggg acgagctgac caagaaccag gtgtccctga cctgtctggt caagggcttc 1080
tacccttccg atatcgccgt ggagtgggag tccaacggcc agcctgagaa caactacaag 1140
accacccctc ctgtgctgga ctccgacggc tccttcttcc tgtactccaa gctcacagtg 1200
gataagtccc ggtggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg 1260
cacaaccact atacccagaa gtccctgtcc ctgtctcctg gcaagtga              1308

<210> 117
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 117
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser
            20                  25                  30          
Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly
                85                  90                  95      
Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Ser Gly
        115                 120                 125             
Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145                 150                 155                 160 
Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu
                165                 170                 175     
Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn
            180                 185                 190         
Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser
        195                 200                 205             
Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 118
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 118
atggaaaccg acaccctgct gctgtgggtc ctgctcctct gggtgccagg ctctaccggc 60
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc 120
atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc 180
acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac 240
ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa 300
gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg 360
acaaagttgg aaataaactc tggtggaggc gggcaggtcc agctgcagca gtctggggct 420
gaactggcaa gacctggggc ctcagtgaag atgtcctgca aggcttctgg ctacaccttt 480
actaggtaca cgatgcactg ggtaaaacag aggcctggac agggtctgga atggattgga 540
tacattaatc ctagccgtgg ttatactaat tacaatcaga agttcaagga caaggccaca 600
ttgactacag acaaatcctc cagcacagcc tacatgcaac tgagcagcct gacatctgag 660
gactctgcag tctattactg tgcaagatat tatgatgatc attactgcct tgactactgg 720
ggccaaggca ccactctcac agtctcctca ggcggatgct ga                    762

<210> 119
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 119
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala
            20                  25                  30          
Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser
                85                  90                  95      
Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
145                 150                 155                 160 
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                165                 170                 175     
Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
            180                 185                 190         
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu
    210                 215                 220                 
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
225                 230                 235                 240 
Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly Cys
                245                 250             


<210> 120
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 120
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg 120
tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg 180
cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac 240
aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac 300
atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat 360
gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctcaagt 420
ggtggaggag gccaaattgt tctcacccag tctccagcaa tcatgtctgc atctccaggg 480
gagaaggtca ccatgacctg cagtgccagc tcaagtgtaa gttacatgaa ctggtaccag 540
cagaagtcag gcacctcccc caaaagatgg atttatgaca catccaaact ggcttctgga 600
gtccctgctc acttcagggg cagtgggtct gggacctctt actctctcac aatcagcggc 660
atggaggctg aagatgctgc cacttattac tgccagcagt ggagtagtaa cccattcacg 720
ttcggctcgg ggacaaagtt ggaaataaac ggcggctgc                        759

<210> 121
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 121
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser
            20                  25                  30          
Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly
                85                  90                  95      
Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu
    130                 135                 140                 
Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly
145                 150                 155                 160 
Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly
                165                 170                 175     
Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr
            180                 185                 190         
Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys
        195                 200                 205             
Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
    210                 215                 220                 
Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu
225                 230                 235                 240 
Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Cys
                245                 250                 255     


<210> 122
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 122
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc 120
atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc 180
acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac 240
ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa 300
gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg 360
acaaagttgg aaataaacgg cggagggagt ggcggaggcg gccaggtcca gctgcagcag 420
tctggggctg aactggcaag acctggggcc tcagtgaaga tgtcctgcaa ggcttctggc 480
tacaccttta ctaggtacac gatgcactgg gtaaaacaga ggcctggaca gggtctggaa 540
tggattggat acattaatcc tagccgtggt tatactaatt acaatcagaa gttcaaggac 600
aaggccacat tgactacaga caaatcctcc agcacagcct acatgcaact gagcagcctg 660
acatctgagg actctgcagt ctattactgt gcaagatatt atgatgatca ttactgcctt 720
gactactggg gccaaggcac cactctcaca gtctcctcag gcggctgc              768

<210> 123
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 123
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala
            20                  25                  30          
Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser
                85                  90                  95      
Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala
145                 150                 155                 160 
Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val
                165                 170                 175     
Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg
            180                 185                 190         
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe
        195                 200                 205             
Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met
    210                 215                 220                 
Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn
225                 230                 235                 240 
Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Gly Gly Cys
                245                 250                 255     


<210> 124
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 124
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg 120
tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg 180
cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac 240
aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac 300
atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat 360
gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctcaggc 420
ggagggagtg gcggaggcgg ccaaattgtt ctcacccagt ctccagcaat catgtctgca 480
tctccagggg agaaggtcac catgacctgc agtgccagct caagtgtaag ttacatgaac 540
tggtaccagc agaagtcagg cacctccccc aaaagatgga tttatgacac atccaaactg 600
gcttctggag tccctgctca cttcaggggc agtgggtctg ggacctctta ctctctcaca 660
atcagcggca tggaggctga agatgctgcc acttattact gccagcagtg gagtagtaac 720
ccattcacgt tcggctcggg gacaaagttg gaaataaacg gcggctgc              768

<210> 125
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 125
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly
            100                 105                 110         
Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Ser Thr Ser Gly
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln
145                 150                 155                 160 
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                165                 170                 175     
Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr
            180                 185                 190         
Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser
        195                 200                 205             
Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
225                 230                 235                 240 
Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln
                245                 250                 255     
Gly Thr Lys Leu Gln Ile Thr Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 126
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 126
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagtc tggtggagga gtggtccagc ccgggagatc actgaggctg 120
tcctgtaagg ctagtggcta cacttttaca cggtacacca tgcattgggt gaggcaggca 180
cctgggaaag gcctggaatg gatcggatac atcaacccta gtaggggata cacaaactac 240
aatcagaaag tcaaggaccg gttcacaatc tctagggaca actctaaaaa caccgctttt 300
ctgcagatgg actcactgag gcctgaggac actggagtgt acttttgtgc tcggtactac 360
gatgatcatt actgcctgga ttactgggga caggggacac ctgtcactgt ctcttccggc 420
tccacatccg gcggaggctc tggcggtgga tctggcggag gcggctcatc cgacatccag 480
atgacacagt ctccctcttc tctgtccgcc tctgtgggcg atcgagtgac aatcacctgt 540
agcgcttcat cctccgtgtc ttacatgaat tggtaccagc agacccctgg caaagctcct 600
aaacgatgga tctacgacac ctccaaactg gcttccggcg tgccttcacg attttctggt 660
tctggttctg ggaccgacta cacctttacc atctcatcac tgcagcctga ggatatcgcc 720
acatactact gtcagcagtg gtctagcaac cctttcacat tcgggcaggg cacaaaactg 780
cagatcaccg agcctaagtc ctgcgacaag acccacacct gtcccccttg cggcggagga 840
agcagcggag gcggatccgg tggccagcct cgggagcctc aggtgtacac cctgcctccc 900
tcccgggacg agctgaccaa gaaccaggtg tccctgacct gtctggtcaa gggcttctac 960
ccttccgata tcgccgtgga gtgggagtcc aacggccagc ctgagaacaa ctacaagacc 1020
acccctcctg tgctggactc cgacggctcc ttcttcctgt actccaagct cacagtggat 1080
aagtcccggt ggcagcaggg caacgtgttc tcctgctccg tgatgcacga ggccctgcac 1140
aaccactata cccagaagtc cctgtccctg tctcctggca agtga                 1185

<210> 127
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 127
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Ser Gly
        115                 120                 125             
Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln
    130                 135                 140                 
Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145                 150                 155                 160 
Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                165                 170                 175     
Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn
            180                 185                 190         
Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
        195                 200                 205             
Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val
    210                 215                 220                 
Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 128
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 128
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccaga tgacacagtc tccctcttct ctgtccgcct ctgtgggcga tcgagtgaca 120
atcacctgta gcgcttcatc ctccgtgtct tacatgaatt ggtaccagca gacccctggc 180
aaagctccta aacgatggat ctacgacacc tccaaactgg cttccggcgt gccttcacga 240
ttttctggtt ctggttctgg gaccgactac acctttacca tctcatcact gcagcctgag 300
gatatcgcca catactactg tcagcagtgg tctagcaacc ctttcacatt cgggcagggc 360
acaaaactgc agatcaccag tggtggagga ggccaggtcc agctggtcca gtctggtgga 420
ggagtggtcc agcccgggag atcactgagg ctgtcctgta aggctagtgg ctacactttt 480
acacggtaca ccatgcattg ggtgaggcag gcacctggga aaggcctgga atggatcgga 540
tacatcaacc ctagtagggg atacacaaac tacaatcaga aagtcaagga ccggttcaca 600
atctctaggg acaactctaa aaacaccgct tttctgcaga tggactcact gaggcctgag 660
gacactggag tgtacttttg tgctcggtac tacgatgatc attactgcct ggattactgg 720
ggacagggga cacctgtcac tgtctcttcc ggcggctgc                        759

<210> 129
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 129
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly
            100                 105                 110         
Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
145                 150                 155                 160 
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                165                 170                 175     
Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
            180                 185                 190         
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
    210                 215                 220                 
Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
225                 230                 235                 240 
Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Gly Cys
                245                 250             


<210> 130
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 130
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagtc tggtggagga gtggtccagc ccgggagatc actgaggctg 120
tcctgtaagg ctagtggcta cacttttaca cggtacacca tgcattgggt gaggcaggca 180
cctgggaaag gcctggaatg gatcggatac atcaacccta gtaggggata cacaaactac 240
aatcagaaag tcaaggaccg gttcacaatc tctagggaca actctaaaaa caccgctttt 300
ctgcagatgg actcactgag gcctgaggac actggagtgt acttttgtgc tcggtactac 360
gatgatcatt actgcctgga ttactgggga caggggacac ctgtcactgt ctcttccagt 420
ggtggaggag gcgacatcca gatgacacag tctccctctt ctctgtccgc ctctgtgggc 480
gatcgagtga caatcacctg tagcgcttca tcctccgtgt cttacatgaa ttggtaccag 540
cagacccctg gcaaagctcc taaacgatgg atctacgaca cctccaaact ggcttccggc 600
gtgccttcac gattttctgg ttctggttct gggaccgact acacctttac catctcatca 660
ctgcagcctg aggatatcgc cacatactac tgtcagcagt ggtctagcaa ccctttcaca 720
ttcgggcagg gcacaaaact gcagatcacc ggcggctgc                        759

<210> 131
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 131
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys
    50                  55                  60                  
Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser
                85                  90                  95      
Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly
    130                 135                 140                 
Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly
145                 150                 155                 160 
Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly
                165                 170                 175     
Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr
            180                 185                 190         
Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn
        195                 200                 205             
Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp
    210                 215                 220                 
Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu
225                 230                 235                 240 
Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Cys
                245                 250                 255     


<210> 132
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 132
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccaga tgacacagtc tccctcttct ctgtccgcct ctgtgggcga tcgagtgaca 120
atcacctgta gcgcttcatc ctccgtgtct tacatgaatt ggtaccagca gacccctggc 180
aaagctccta aacgatggat ctacgacacc tccaaactgg cttccggcgt gccttcacga 240
ttttctggtt ctggttctgg gaccgactac acctttacca tctcatcact gcagcctgag 300
gatatcgcca catactactg tcagcagtgg tctagcaacc ctttcacatt cgggcagggc 360
acaaaactgc agatcaccgg cggagggagt ggcggaggcg gccaggtcca gctggtccag 420
tctggtggag gagtggtcca gcccgggaga tcactgaggc tgtcctgtaa ggctagtggc 480
tacactttta cacggtacac catgcattgg gtgaggcagg cacctgggaa aggcctggaa 540
tggatcggat acatcaaccc tagtagggga tacacaaact acaatcagaa agtcaaggac 600
cggttcacaa tctctaggga caactctaaa aacaccgctt ttctgcagat ggactcactg 660
aggcctgagg acactggagt gtacttttgt gctcggtact acgatgatca ttactgcctg 720
gattactggg gacaggggac acctgtcact gtctcttccg gcggctgc              768

<210> 133
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 133
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly
            100                 105                 110         
Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
145                 150                 155                 160 
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val
                165                 170                 175     
Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg
            180                 185                 190         
Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe
        195                 200                 205             
Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu
    210                 215                 220                 
Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn
225                 230                 235                 240 
Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Gly Gly Cys
                245                 250                 255     


<210> 134
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 134
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagtc tggtggagga gtggtccagc ccgggagatc actgaggctg 120
tcctgtaagg ctagtggcta cacttttaca cggtacacca tgcattgggt gaggcaggca 180
cctgggaaag gcctggaatg gatcggatac atcaacccta gtaggggata cacaaactac 240
aatcagaaag tcaaggaccg gttcacaatc tctagggaca actctaaaaa caccgctttt 300
ctgcagatgg actcactgag gcctgaggac actggagtgt acttttgtgc tcggtactac 360
gatgatcatt actgcctgga ttactgggga caggggacac ctgtcactgt ctcttccggc 420
ggagggagtg gcggaggcgg cgacatccag atgacacagt ctccctcttc tctgtccgcc 480
tctgtgggcg atcgagtgac aatcacctgt agcgcttcat cctccgtgtc ttacatgaat 540
tggtaccagc agacccctgg caaagctcct aaacgatgga tctacgacac ctccaaactg 600
gcttccggcg tgccttcacg attttctggt tctggttctg ggaccgacta cacctttacc 660
atctcatcac tgcagcctga ggatatcgcc acatactact gtcagcagtg gtctagcaac 720
cctttcacat tcgggcaggg cacaaaactg cagatcaccg gcggctgc              768

<210> 135
<211> 394
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 135
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile
                85                  90                  95      
Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val
145                 150                 155                 160 
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
                165                 170                 175     
Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr
            180                 185                 190         
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser
        195                 200                 205             
Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala
225                 230                 235                 240 
Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln
                245                 250                 255     
Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His
            260                 265                 270         
Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly
        275                 280                 285             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
    290                 295                 300                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
305                 310                 315                 320 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                325                 330                 335     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            340                 345                 350         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        355                 360                 365             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    370                 375                 380                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 


<210> 136
<211> 1185
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 136
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagag tggagctgag gtgaaaaaac ccggcgcttc cgtcaaagtc 120
tcctgtaagg ctagcggata cacctttact cgctacacca tgcattgggt ccggcaggct 180
cccggacagg gcctggaatg gatgggatac atcaaccctt ctcggggcta cacaaactac 240
aatcagaaat tcaaggatcg agtgaccatg acaaccgaca cttcaatctc taccgcttac 300
atggaactgt ctcggctgag gagtgacgat accgctgtct actactgtgc tcggtactac 360
gacgaccatt actgcctgga ttactggggg cagggcacac tggtgactgt gtctagcggc 420
tccacatccg gcggaggctc tggcggtgga tctggcggag gcggctcatc cgaaatcgtg 480
ctgactcagt cccctgctac actgtctctg tcacctggcg aacgagcaac actgtcctgt 540
tctgcctctt cttctgtctc atacatgaac tggtaccagc agaaacctgg acaggctcct 600
agactgctga tctacgacac ctctaaactg gcatctggcg tgcccgctca ttttcgtggc 660
tctggatctg gaaccgactt taccctgacc atctcttccc tggaacctga ggattttgcc 720
gtgtactact gccagcagtg gtctagtaac cctttcactt ttggccaggg cactaaagtg 780
gagatcaagg agcctaagtc ctgcgacaag acccacacct gtcccccttg cggcggagga 840
agcagcggag gcggatccgg tggccagcct cgggagcctc aggtgtacac cctgcctccc 900
tcccgggacg agctgaccaa gaaccaggtg tccctgacct gtctggtcaa gggcttctac 960
ccttccgata tcgccgtgga gtgggagtcc aacggccagc ctgagaacaa ctacaagacc 1020
acccctcctg tgctggactc cgacggctcc ttcttcctgt actccaagct cacagtggat 1080
aagtcccggt ggcagcaggg caacgtgttc tcctgctccg tgatgcacga ggccctgcac 1140
aaccactata cccagaagtc cctgtccctg tctcctggca agtga                 1185

<210> 137
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 137
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser
        35                  40                  45              
Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg
    50                  55                  60                  
Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His
65                  70                  75                  80  
Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
                85                  90                  95      
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser
            100                 105                 110         
Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly
        115                 120                 125             
Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
    130                 135                 140                 
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
145                 150                 155                 160 
Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
                165                 170                 175     
Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn
            180                 185                 190         
Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser
        195                 200                 205             
Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val
    210                 215                 220                 
Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250             


<210> 138
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 138
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaatcgtgc tgactcagtc ccctgctaca ctgtctctgt cacctggcga acgagcaaca 120
ctgtcctgtt ctgcctcttc ttctgtctca tacatgaact ggtaccagca gaaacctgga 180
caggctccta gactgctgat ctacgacacc tctaaactgg catctggcgt gcccgctcat 240
tttcgtggct ctggatctgg aaccgacttt accctgacca tctcttccct ggaacctgag 300
gattttgccg tgtactactg ccagcagtgg tctagtaacc ctttcacttt tggccagggc 360
actaaagtgg agatcaagag tggtggagga ggccaggtcc agctggtcca gagtggagct 420
gaggtgaaaa aacccggcgc ttccgtcaaa gtctcctgta aggctagcgg atacaccttt 480
actcgctaca ccatgcattg ggtccggcag gctcccggac agggcctgga atggatggga 540
tacatcaacc cttctcgggg ctacacaaac tacaatcaga aattcaagga tcgagtgacc 600
atgacaaccg acacttcaat ctctaccgct tacatggaac tgtctcggct gaggagtgac 660
gataccgctg tctactactg tgctcggtac tacgacgacc attactgcct ggattactgg 720
gggcagggca cactggtgac tgtgtctagc ggcggctgc                        759

<210> 139
<211> 253
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 139
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile
                85                  90                  95      
Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
145                 150                 155                 160 
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                165                 170                 175     
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
            180                 185                 190         
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
    210                 215                 220                 
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
225                 230                 235                 240 
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250             


<210> 140
<211> 759
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 140
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagag tggagctgag gtgaaaaaac ccggcgcttc cgtcaaagtc 120
tcctgtaagg ctagcggata cacctttact cgctacacca tgcattgggt ccggcaggct 180
cccggacagg gcctggaatg gatgggatac atcaaccctt ctcggggcta cacaaactac 240
aatcagaaat tcaaggatcg agtgaccatg acaaccgaca cttcaatctc taccgcttac 300
atggaactgt ctcggctgag gagtgacgat accgctgtct actactgtgc tcggtactac 360
gacgaccatt actgcctgga ttactggggg cagggcacac tggtgactgt gtctagcagt 420
ggtggaggag gcgaaatcgt gctgactcag tcccctgcta cactgtctct gtcacctggc 480
gaacgagcaa cactgtcctg ttctgcctct tcttctgtct catacatgaa ctggtaccag 540
cagaaacctg gacaggctcc tagactgctg atctacgaca cctctaaact ggcatctggc 600
gtgcccgctc attttcgtgg ctctggatct ggaaccgact ttaccctgac catctcttcc 660
ctggaacctg aggattttgc cgtgtactac tgccagcagt ggtctagtaa ccctttcact 720
tttggccagg gcactaaagt ggagatcaag ggcggctgc                        759

<210> 141
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 141
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly
            100                 105                 110         
Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro
        115                 120                 125             
Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
    130                 135                 140                 
Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu
145                 150                 155                 160 
Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln
                165                 170                 175     
Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr
            180                 185                 190         
Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr
        195                 200                 205             
Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly
    210                 215                 220                 
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
225                 230                 235     


<210> 142
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 142
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaatcgtgc tgactcagtc ccctgctaca ctgtctctgt cacctggcga acgagcaaca 120
ctgtcctgtt ctgcctcttc ttctgtctca tacatgaact ggtaccagca gaaacctgga 180
caggctccta gactgctgat ctacgacacc tctaaactgg catctggcgt gcccgctcat 240
tttcgtggct ctggatctgg aaccgacttt accctgacca tctcttccct ggaacctgag 300
gattttgccg tgtactactg ccagcagtgg tctagtaacc ctttcacttt tggccagggc 360
actaaagtgg agatcaaggg cggagggagt ggcggaggcg gccaggtcca gctggtccag 420
agtggagctg aggtgaaaaa acccggcgct tccgtcaaag tctcctgtaa ggctagcgga 480
tacaccttta ctcgctacac catgcattgg gtccggcagg ctcccggaca gggcctggaa 540
tggatgggat acatcaaccc ttctcggggc tacacaaact acaatcagaa attcaaggat 600
cgagtgacca tgacaaccga cacttcaatc tctaccgctt acatggaact gtctcggctg 660
aggagtgacg ataccgctgt ctactactgt gctcggtact acgacgacca ttactgcctg 720
gattactggg ggcagggcac actggtgact gtgtctagcg gcggctgc              768

<210> 143
<211> 256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 143
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
        35                  40                  45              
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
    50                  55                  60                  
Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
65                  70                  75                  80  
Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile
                85                  90                  95      
Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu
145                 150                 155                 160 
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val
                165                 170                 175     
Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
            180                 185                 190         
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe
        195                 200                 205             
Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
    210                 215                 220                 
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn
225                 230                 235                 240 
Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250                 255     


<210> 144
<211> 768
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 144
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtccagc tggtccagag tggagctgag gtgaaaaaac ccggcgcttc cgtcaaagtc 120
tcctgtaagg ctagcggata cacctttact cgctacacca tgcattgggt ccggcaggct 180
cccggacagg gcctggaatg gatgggatac atcaaccctt ctcggggcta cacaaactac 240
aatcagaaat tcaaggatcg agtgaccatg acaaccgaca cttcaatctc taccgcttac 300
atggaactgt ctcggctgag gagtgacgat accgctgtct actactgtgc tcggtactac 360
gacgaccatt actgcctgga ttactggggg cagggcacac tggtgactgt gtctagcggc 420
ggagggagtg gcggaggcgg cgaaatcgtg ctgactcagt cccctgctac actgtctctg 480
tcacctggcg aacgagcaac actgtcctgt tctgcctctt cttctgtctc atacatgaac 540
tggtaccagc agaaacctgg acaggctcct agactgctga tctacgacac ctctaaactg 600
gcatctggcg tgcccgctca ttttcgtggc tctggatctg gaaccgactt taccctgacc 660
atctcttccc tggaacctga ggattttgcc gtgtactact gccagcagtg gtctagtaac 720
cctttcactt ttggccaggg cactaaagtg gagatcaagg gcggctgc              768

<210> 145
<211> 389
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 145
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Ser Ser Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
145                 150                 155                 160 
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
                165                 170                 175     
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
            180                 185                 190         
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
        195                 200                 205             
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
    210                 215                 220                 
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
225                 230                 235                 240 
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
                245                 250                 255     
Val Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            260                 265                 270         
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro
        275                 280                 285             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
    290                 295                 300                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
305                 310                 315                 320 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                325                 330                 335     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            340                 345                 350         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        355                 360                 365             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    370                 375                 380                 
Leu Ser Pro Gly Lys
385                 


<210> 146
<211> 1170
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 146
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt ggctccacat ccggcggagg ctctggcggt 420
ggatctggcg gaggcggctc atccgacatc cagctgactc agcccaactc tgtgtctacg 480
tctctaggaa gcacagtcaa gctgtcttgc acactcagct ctggtaacat agaaaacaac 540
tatgtgcact ggtaccagct atatgaggga agatctccca ccactatgat ttatgatgat 600
gataagagac cggatggtgt ccctgacagg ttctctggct ccattgacag gtcttccaac 660
tcagccttcc tgacaatcca taatgtggca attgaagatg aagctatcta cttctgtcat 720
tcttatgtta gtagttttaa tgttttcggc ggtggaacaa agctcactgt ccttgagcct 780
aagtcctgcg acaagaccca cacctgtccc ccttgcggcg gaggaagcag cggaggcgga 840
tccggtggcc agcctcggga gcctcaggtg tacaccctgc ctccctcccg ggacgagctg 900
accaagaacc aggtgtccct gacctgtctg gtcaagggct tctacccttc cgatatcgcc 960
gtggagtggg agtccaacgg ccagcctgag aacaactaca agaccacccc tcctgtgctg 1020
gactccgacg gctccttctt cctgtactcc aagctcacag tggataagtc ccggtggcag 1080
cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctatacccag 1140
aagtccctgt ccctgtctcc tggcaagtga                                  1170

<210> 147
<211> 389
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 147
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Ser Ser Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
145                 150                 155                 160 
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
                165                 170                 175     
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
            180                 185                 190         
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
        195                 200                 205             
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
    210                 215                 220                 
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
225                 230                 235                 240 
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
                245                 250                 255     
Val Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            260                 265                 270         
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro
        275                 280                 285             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
    290                 295                 300                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
305                 310                 315                 320 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                325                 330                 335     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            340                 345                 350         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        355                 360                 365             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    370                 375                 380                 
Leu Ser Pro Gly Lys
385                 


<210> 148
<211> 1170
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 148
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt ggctccacat ccggcggagg ctctggcggt 420
ggatctggcg gaggcggctc atccgacatc cagctgactc agcccaactc tgtgtctacg 480
tctctaggaa gcacagtcaa gctgtcttgc acactcagct ctggtaacat agaaaacaac 540
tatgtgcact ggtaccagct atatgaggga agatctccca ccactatgat ttatgatgat 600
gataagagac cggatggtgt ccctgacagg ttctctggct ccattgacag gtcttccaac 660
tcagccttcc tgacaatcca taatgtggca attgaagatg aagctatcta cttctgtcat 720
tcttatgtta gtagttttaa tgttttcggc ggtggaacaa agctcactgt ccttgagcct 780
aagtcctgcg acaagaccca cacctgtccc ccttgcggcg gaggaagcag cggaggcgga 840
tccggtggcc agcctcggga gcctcaggtg tacaccctgc ctccctcccg ggacgagctg 900
accaagaacc aggtgtccct gacctgtctg gtcaagggct tctacccttc cgatatcgcc 960
gtggagtggg agtccaacgg ccagcctgag aacaactaca agaccacccc tcctgtgctg 1020
gactccgacg gctccttctt cctgtactcc aagctcacag tggataagtc ccggtggcag 1080
cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctatacccag 1140
aagtccctgt ccctgtctcc tggcaagtga                                  1170

<210> 149
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 149
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Ser Gly Gly Gly Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser
    130                 135                 140                 
Val Ser Thr Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser
145                 150                 155                 160 
Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu
                165                 170                 175     
Gly Arg Ser Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp
            180                 185                 190         
Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser
        195                 200                 205             
Ala Phe Leu Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr
    210                 215                 220                 
Phe Cys His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr
225                 230                 235                 240 
Lys Leu Thr Val Leu Gly Gly Cys
                245             


<210> 150
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 150
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt agtggtggag gaggcgacat ccagctgact 420
cagcccaact ctgtgtctac gtctctagga agcacagtca agctgtcttg cacactcagc 480
tctggtaaca tagaaaacaa ctatgtgcac tggtaccagc tatatgaggg aagatctccc 540
accactatga tttatgatga tgataagaga ccggatggtg tccctgacag gttctctggc 600
tccattgaca ggtcttccaa ctcagccttc ctgacaatcc ataatgtggc aattgaagat 660
gaagctatct acttctgtca ttcttatgtt agtagtttta atgttttcgg cggtggaaca 720
aagctcactg tccttggcgg ctgc                                        744

<210> 151
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 151
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Ser Gly Gly Gly Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser
    130                 135                 140                 
Val Ser Thr Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser
145                 150                 155                 160 
Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu
                165                 170                 175     
Gly Arg Ser Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp
            180                 185                 190         
Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser
        195                 200                 205             
Ala Phe Leu Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr
    210                 215                 220                 
Phe Cys His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr
225                 230                 235                 240 
Lys Leu Thr Val Leu Gly Gly Cys
                245             


<210> 152
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 152
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt agtggtggag gaggcgacat ccagctgact 420
cagcccaact ctgtgtctac gtctctagga agcacagtca agctgtcttg cacactcagc 480
tctggtaaca tagaaaacaa ctatgtgcac tggtaccagc tatatgaggg aagatctccc 540
accactatga tttatgatga tgataagaga ccggatggtg tccctgacag gttctctggc 600
tccattgaca ggtcttccaa ctcagccttc ctgacaatcc ataatgtggc aattgaagat 660
gaagctatct acttctgtca ttcttatgtt agtagtttta atgttttcgg cggtggaaca 720
aagctcactg tccttggcgg ctgc                                        744

<210> 153
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 153
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Leu Thr Gln
    130                 135                 140                 
Pro Asn Ser Val Ser Thr Ser Leu Gly Ser Thr Val Lys Leu Ser Cys
145                 150                 155                 160 
Thr Leu Ser Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln
                165                 170                 175     
Leu Tyr Glu Gly Arg Ser Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys
            180                 185                 190         
Arg Pro Asp Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser
        195                 200                 205             
Ser Asn Ser Ala Phe Leu Thr Ile His Asn Val Ala Ile Glu Asp Glu
    210                 215                 220                 
Ala Ile Tyr Phe Cys His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly
225                 230                 235                 240 
Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Cys
                245                 250     


<210> 154
<211> 753
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 154
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt ggcggaggga gtggcggagg cggcgacatc 420
cagctgactc agcccaactc tgtgtctacg tctctaggaa gcacagtcaa gctgtcttgc 480
acactcagct ctggtaacat agaaaacaac tatgtgcact ggtaccagct atatgaggga 540
agatctccca ccactatgat ttatgatgat gataagagac cggatggtgt ccctgacagg 600
ttctctggct ccattgacag gtcttccaac tcagccttcc tgacaatcca taatgtggca 660
attgaagatg aagctatcta cttctgtcat tcttatgtta gtagttttaa tgttttcggc 720
ggtggaacaa agctcactgt ccttggcggc tgc                              753

<210> 155
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 155
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Pro Asn Ser Val Ser Thr
            20                  25                  30          
Ser Leu Gly Ser Thr Val Lys Leu Ser Cys Thr Leu Ser Ser Gly Asn
        35                  40                  45              
Ile Glu Asn Asn Tyr Val His Trp Tyr Gln Leu Tyr Glu Gly Arg Ser
    50                  55                  60                  
Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys Arg Pro Asp Gly Val Pro
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Phe Leu
                85                  90                  95      
Thr Ile His Asn Val Ala Ile Glu Asp Glu Ala Ile Tyr Phe Cys His
            100                 105                 110         
Ser Tyr Val Ser Ser Phe Asn Val Phe Gly Gly Gly Thr Lys Leu Thr
        115                 120                 125             
Val Leu Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln Leu Thr Gln
    130                 135                 140                 
Pro Asn Ser Val Ser Thr Ser Leu Gly Ser Thr Val Lys Leu Ser Cys
145                 150                 155                 160 
Thr Leu Ser Ser Gly Asn Ile Glu Asn Asn Tyr Val His Trp Tyr Gln
                165                 170                 175     
Leu Tyr Glu Gly Arg Ser Pro Thr Thr Met Ile Tyr Asp Asp Asp Lys
            180                 185                 190         
Arg Pro Asp Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg Ser
        195                 200                 205             
Ser Asn Ser Ala Phe Leu Thr Ile His Asn Val Ala Ile Glu Asp Glu
    210                 215                 220                 
Ala Ile Tyr Phe Cys His Ser Tyr Val Ser Ser Phe Asn Val Phe Gly
225                 230                 235                 240 
Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Cys
                245                 250     


<210> 156
<211> 753
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 156
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gacatccagc tgactcagcc caactctgtg tctacgtctc taggaagcac agtcaagctg 120
tcttgcacac tcagctctgg taacatagaa aacaactatg tgcactggta ccagctatat 180
gagggaagat ctcccaccac tatgatttat gatgatgata agagaccgga tggtgtccct 240
gacaggttct ctggctccat tgacaggtct tccaactcag ccttcctgac aatccataat 300
gtggcaattg aagatgaagc tatctacttc tgtcattctt atgttagtag ttttaatgtt 360
ttcggcggtg gaacaaagct cactgtcctt ggcggaggga gtggcggagg cggcgacatc 420
cagctgactc agcccaactc tgtgtctacg tctctaggaa gcacagtcaa gctgtcttgc 480
acactcagct ctggtaacat agaaaacaac tatgtgcact ggtaccagct atatgaggga 540
agatctccca ccactatgat ttatgatgat gataagagac cggatggtgt ccctgacagg 600
ttctctggct ccattgacag gtcttccaac tcagccttcc tgacaatcca taatgtggca 660
attgaagatg aagctatcta cttctgtcat tcttatgtta gtagttttaa tgttttcggc 720
ggtggaacaa agctcactgt ccttggcggc tgc                              753

<210> 157
<211> 395
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 157
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser
            100                 105                 110         
Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
        115                 120                 125             
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro
145                 150                 155                 160 
Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser
                165                 170                 175     
Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
            180                 185                 190         
Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr Val Asp
        195                 200                 205             
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
    210                 215                 220                 
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
225                 230                 235                 240 
Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp Gly Arg
                245                 250                 255     
Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr
            260                 265                 270         
His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
        275                 280                 285             
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
    290                 295                 300                 
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
305                 310                 315                 320 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                325                 330                 335     
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
            340                 345                 350         
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
        355                 360                 365             
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
    370                 375                 380                 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 395 


<210> 158
<211> 1188
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 158
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc 120
ctgagctgcc gcgcgagcca gagcgtgagc agctatctgg cgtggtatca gcagaaaccg 180
ggccaggcgc cgcgcctgct gatttatgat gcgagcaacc gcgcgaccgg cattccggcg 240
cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctggaaccg 300
gaagattttg cggtgtatta ttgccagcag cgcagcaact ggccgccgct gacctttggc 360
ggcggcacca aagtggaaat taaaggctcc acatccggcg gaggctctgg cggtggatct 420
ggcggaggcg gctcatccca ggtgcagctg gtggaaagcg gcggcggcgt ggtgcagccg 480
ggccgcagcc tgcgcctgag ctgcgcggcg agcggcttta aatttagcgg ctatggcatg 540
cattgggtgc gccaggcgcc gggcaaaggc ctggaatggg tggcggtgat ttggtatgat 600
ggcagcaaaa aatattatgt ggatagcgtg aaaggccgct ttaccattag ccgcgataac 660
agcaaaaaca ccctgtatct gcagatgaac agcctgcgcg cggaagatac cgcggtgtat 720
tattgcgcgc gccagatggg ctattggcat tttgatctgt ggggccgcgg caccctggtg 780
accgtgagca gcgagcctaa gtcctgcgac aagacccaca cctgtccccc ttgcggcgga 840
ggaagcagcg gaggcggatc cggtggccag cctcgggagc ctcaggtgta caccctgcct 900
ccctcccggg acgagctgac caagaaccag gtgtccctga cctgtctggt caagggcttc 960
tacccttccg atatcgccgt ggagtgggag tccaacggcc agcctgagaa caactacaag 1020
accacccctc ctgtgctgga ctccgacggc tccttcttcc tgtactccaa gctcacagtg 1080
gataagtccc ggtggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg 1140
cacaaccact atacccagaa gtccctgtcc ctgtctcctg gcaagtga              1188

<210> 159
<211> 395
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 159
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys
        35                  40                  45              
Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr
65                  70                  75                  80  
Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp
        115                 120                 125             
Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly
    130                 135                 140                 
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val Leu
145                 150                 155                 160 
Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr
                165                 170                 175     
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr
            180                 185                 190         
Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser
        195                 200                 205             
Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala
225                 230                 235                 240 
Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Leu Thr Phe Gly
                245                 250                 255     
Gly Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr
            260                 265                 270         
His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
        275                 280                 285             
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
    290                 295                 300                 
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
305                 310                 315                 320 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                325                 330                 335     
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
            340                 345                 350         
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
        355                 360                 365             
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
    370                 375                 380                 
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
385                 390                 395 


<210> 160
<211> 1188
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 160
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg 120
agctgcgcgg cgagcggctt taaatttagc ggctatggca tgcattgggt gcgccaggcg 180
ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa aaaatattat 240
gtggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat 300
ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccagatg 360
ggctattggc attttgatct gtggggccgc ggcaccctgg tgaccgtgag cagcggctcc 420
acatccggcg gaggctctgg cggtggatct ggcggaggcg gctcatccga aattgtgctg 480
acccagagcc cggcgaccct gagcctgagc ccgggcgaac gcgcgaccct gagctgccgc 540
gcgagccaga gcgtgagcag ctatctggcg tggtatcagc agaaaccggg ccaggcgccg 600
cgcctgctga tttatgatgc gagcaaccgc gcgaccggca ttccggcgcg ctttagcggc 660
agcggcagcg gcaccgattt taccctgacc attagcagcc tggaaccgga agattttgcg 720
gtgtattatt gccagcagcg cagcaactgg ccgccgctga cctttggcgg cggcaccaaa 780
gtggaaatta aagagcctaa gtcctgcgac aagacccaca cctgtccccc ttgcggcgga 840
ggaagcagcg gaggcggatc cggtggccag cctcgggagc ctcaggtgta caccctgcct 900
ccctcccggg acgagctgac caagaaccag gtgtccctga cctgtctggt caagggcttc 960
tacccttccg atatcgccgt ggagtgggag tccaacggcc agcctgagaa caactacaag 1020
accacccctc ctgtgctgga ctccgacggc tccttcttcc tgtactccaa gctcacagtg 1080
gataagtccc ggtggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg 1140
cacaaccact atacccagaa gtccctgtcc ctgtctcctg gcaagtga              1188

<210> 161
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 161
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser
            100                 105                 110         
Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
        115                 120                 125             
Ser Gly Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val
    130                 135                 140                 
Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
145                 150                 155                 160 
Lys Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys
                165                 170                 175     
Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr
            180                 185                 190         
Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
        195                 200                 205             
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
    210                 215                 220                 
Ala Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu
225                 230                 235                 240 
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Cys
                245                 250                 


<210> 162
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 162
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc 120
ctgagctgcc gcgcgagcca gagcgtgagc agctatctgg cgtggtatca gcagaaaccg 180
ggccaggcgc cgcgcctgct gatttatgat gcgagcaacc gcgcgaccgg cattccggcg 240
cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctggaaccg 300
gaagattttg cggtgtatta ttgccagcag cgcagcaact ggccgccgct gacctttggc 360
ggcggcacca aagtggaaat taaaagtggt ggaggaggcc aggtgcagct ggtggaaagc 420
ggcggcggcg tggtgcagcc gggccgcagc ctgcgcctga gctgcgcggc gagcggcttt 480
aaatttagcg gctatggcat gcattgggtg cgccaggcgc cgggcaaagg cctggaatgg 540
gtggcggtga tttggtatga tggcagcaaa aaatattatg tggatagcgt gaaaggccgc 600
tttaccatta gccgcgataa cagcaaaaac accctgtatc tgcagatgaa cagcctgcgc 660
gcggaagata ccgcggtgta ttattgcgcg cgccagatgg gctattggca ttttgatctg 720
tggggccgcg gcaccctggt gaccgtgagc agcggcggct gc                    762

<210> 163
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 163
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys
        35                  40                  45              
Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr
65                  70                  75                  80  
Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp
        115                 120                 125             
Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu
    130                 135                 140                 
Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu
145                 150                 155                 160 
Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu
                165                 170                 175     
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
            180                 185                 190         
Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser
        195                 200                 205             
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
    210                 215                 220                 
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro Leu
225                 230                 235                 240 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Cys
                245                 250                 


<210> 164
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 164
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg 120
agctgcgcgg cgagcggctt taaatttagc ggctatggca tgcattgggt gcgccaggcg 180
ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa aaaatattat 240
gtggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat 300
ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccagatg 360
ggctattggc attttgatct gtggggccgc ggcaccctgg tgaccgtgag cagcagtggt 420
ggaggaggcg aaattgtgct gacccagagc ccggcgaccc tgagcctgag cccgggcgaa 480
cgcgcgaccc tgagctgccg cgcgagccag agcgtgagca gctatctggc gtggtatcag 540
cagaaaccgg gccaggcgcc gcgcctgctg atttatgatg cgagcaaccg cgcgaccggc 600
attccggcgc gctttagcgg cagcggcagc ggcaccgatt ttaccctgac cattagcagc 660
ctggaaccgg aagattttgc ggtgtattat tgccagcagc gcagcaactg gccgccgctg 720
acctttggcg gcggcaccaa agtggaaatt aaaggcggct gc                    762

<210> 165
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 165
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser
            100                 105                 110         
Asn Trp Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly
    130                 135                 140                 
Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala
145                 150                 155                 160 
Ser Gly Phe Lys Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala
                165                 170                 175     
Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser
            180                 185                 190         
Lys Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
        195                 200                 205             
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
    210                 215                 220                 
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His
225                 230                 235                 240 
Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly
                245                 250                 255     
Cys
    


<210> 166
<211> 771
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 166
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc 120
ctgagctgcc gcgcgagcca gagcgtgagc agctatctgg cgtggtatca gcagaaaccg 180
ggccaggcgc cgcgcctgct gatttatgat gcgagcaacc gcgcgaccgg cattccggcg 240
cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctggaaccg 300
gaagattttg cggtgtatta ttgccagcag cgcagcaact ggccgccgct gacctttggc 360
ggcggcacca aagtggaaat taaaggcgga gggagtggcg gaggcggcca ggtgcagctg 420
gtggaaagcg gcggcggcgt ggtgcagccg ggccgcagcc tgcgcctgag ctgcgcggcg 480
agcggcttta aatttagcgg ctatggcatg cattgggtgc gccaggcgcc gggcaaaggc 540
ctggaatggg tggcggtgat ttggtatgat ggcagcaaaa aatattatgt ggatagcgtg 600
aaaggccgct ttaccattag ccgcgataac agcaaaaaca ccctgtatct gcagatgaac 660
agcctgcgcg cggaagatac cgcggtgtat tattgcgcgc gccagatggg ctattggcat 720
tttgatctgt ggggccgcgg caccctggtg accgtgagca gcggcggctg c          771

<210> 167
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 167
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys
        35                  40                  45              
Phe Ser Gly Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Lys Tyr Tyr
65                  70                  75                  80  
Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys
                85                  90                  95      
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gln Met Gly Tyr Trp His Phe Asp Leu Trp
        115                 120                 125             
Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser
145                 150                 155                 160 
Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser
                165                 170                 175     
Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu
            180                 185                 190         
Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe
        195                 200                 205             
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
    210                 215                 220                 
Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp
225                 230                 235                 240 
Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly
                245                 250                 255     
Cys
    


<210> 168
<211> 771
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 168
atggaaaccg acaccctgct gctgtgggtg ctgctgctct gggtcccagg ctccaccggt 60
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg 120
agctgcgcgg cgagcggctt taaatttagc ggctatggca tgcattgggt gcgccaggcg 180
ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa aaaatattat 240
gtggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat 300
ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccagatg 360
ggctattggc attttgatct gtggggccgc ggcaccctgg tgaccgtgag cagcggcgga 420
gggagtggcg gaggcggcga aattgtgctg acccagagcc cggcgaccct gagcctgagc 480
ccgggcgaac gcgcgaccct gagctgccgc gcgagccaga gcgtgagcag ctatctggcg 540
tggtatcagc agaaaccggg ccaggcgccg cgcctgctga tttatgatgc gagcaaccgc 600
gcgaccggca ttccggcgcg ctttagcggc agcggcagcg gcaccgattt taccctgacc 660
attagcagcc tggaaccgga agattttgcg gtgtattatt gccagcagcg cagcaactgg 720
ccgccgctga cctttggcgg cggcaccaaa gtggaaatta aaggcggctg c          771

<210> 169
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 169
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc 60
atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagtcaggc 120
acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcac 180
ttcaggggca gtgggtctgg gacctcttac tctctcacaa tcagcggcat ggaggctgaa 240
gatgctgcca cttattactg ccagcagtgg agtagtaacc cattcacgtt cggctcgggg 300
acaaagttgg aaataaac                                               318

<210> 170
<211> 318
<212> DNA
<213> Homo sapiens

<400> 170
gacatccaga tgacccagtc tccttcttct ctgtctgctt ctgtcggaga cagagtcaca 60
atcacatgtt ctgcttctag ctctgtctct tacatgaact ggtaccagca gacacctgga 120
aaggctccta agcggtggat ctacgacaca tctaagctcg cttctggagt cccttctaga 180
ttctctggtt ctggctctgg aacagactac acattcacaa tctcttctct ccaacctgag 240
gacatcgcta catactactg ccaacagtgg tctagcaatc ctttcacatt cggacaggga 300
acaaagctgc agatcaca                                               318

<210> 171
<211> 106
<212> PRT
<213> Homo sapiens

<400> 171
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu
65                  70                  75                  80  
Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr
            100                 105     


<210> 172
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 172
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gtgccagctc aagtgtaagt tacatgaact ggtaccaaca gaaacctggc 120
caggctccca ggctcctcat ctatgacaca tccaaactgg cttctggagt ccctgctcac 180
ttcaggggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa 240
gattttgcag tttattactg tcagcagtgg agtagtaacc cattcacgtt cggccaaggg 300
accaaggtgg aaatcaaa                                               318

<210> 173
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 173
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu
65                  70                  75                  80  
Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105     


<210> 174
<211> 357
<212> DNA
<213> Mus musculus

<400> 174
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg 60
tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg 120
cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac 180
aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac 240
atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat 300
gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctca    357

<210> 175
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 175
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg 60
tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg 120
cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac 180
aaatgcaact gagcagcctg acatctgagg actctgcagt ctattactgt gcaagatatt 240
attcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac 300
gatgatcatt actcacttga ctactggggc caaggcacca ctctcacagt ctcctca    357

<210> 176
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 176
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 177
<211> 357
<212> DNA
<213> Homo sapiens

<400> 177
caggttcagc tggtgcagtc tggaggagga gtcgtccagc ctggaaggtc cctgagactg 60
tcttgtaagg cttctggata caccttcact agatacacaa tgcactgggt cagacaggct 120
cctggaaagg gactcgagtg gattggatac attaatccta gcagaggtta tactaactac 180
aatcagactg cagatggact cactcagacc tgaggatacc ggagtctatt tttgtgctag 240
atattacagg tgaaggacag attcacaatt tctagagaca attctaagaa tacagccttc 300
gatgaccact actgtctgga ctactggggc caaggtaccc cggtcaccgt gagctca    357

<210> 178
<211> 119
<212> PRT
<213> Homo sapiens

<400> 178
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
    50                  55                  60                  
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
65                  70                  75                  80  
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Pro Val Thr Val Ser Ser
        115                 


<210> 179
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 179
caggttcagc tggtgcagtc tggaggagga gtcgtccagc ctggaaggtc cctgagactg 60
tcttgtaagg cttctggata caccttcact agatacacaa tgcactgggt cagacaggct 120
cctggaaagg gactcgagtg gattggatac attaatccta gcagaggtta tactaactac 180
aatcagaagg tgaaggacag attcacaatt tctagagaca attctaagaa tacagccttc 240
ctgcagatgg actcactcag acctgaggat accggagtct atttttgtgc tagatattac 300
gatgaccact actcactgga ctactggggc caaggtaccc cggtcaccgt gagctca    357

<210> 180
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 180
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val
    50                  55                  60                  
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe
65                  70                  75                  80  
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Pro Val Thr Val Ser Ser
        115                 


<210> 181
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 181
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc aggtacacga tgcactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatac attaatccta gccgtggtta tactaattac 180
aatcagaagt tcaaggacag ggtcaccatg accacagaca cgtccatcag cacagcctac 240
atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagatattat 300
gatgatcatt actgccttga ctactggggc cagggcaccc tggtcaccgt ctcctca    357

<210> 182
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 182
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 183
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 183
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc aggtacacga tgcactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatac attaatccta gccgtggtta tactaattac 180
aatcagaagt tcaaggacag ggtcaccatg accacagaca cgtccatcag cacagcctac 240
atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagatattat 300
gatgatcatt actcacttga ctactggggc cagggcaccc tggtcaccgt ctcctca    357

<210> 184
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 184
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 185
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antigen binding construct or subpart thereof

<400> 185
Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser
 1               5                  10                  15      
Val Gly Val Trp Gly Gln
            20          


<210> 186
<211> 185
<212> PRT
<213> Homo sapiens

<400> 186
Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val
 1               5                  10                  15      
Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly
            20                  25                  30          
Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu
        35                  40                  45              
Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu
    50                  55                  60                  
Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly
65                  70                  75                  80  
Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val
                85                  90                  95      
Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val
            100                 105                 110         
Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr
        115                 120                 125             
Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala
    130                 135                 140                 
Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro
145                 150                 155                 160 
Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu
                165                 170                 175     
Tyr Ser Gly Leu Asn Gln Arg Arg Ile
            180                 185 


<210> 187
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 NH1

<400> 187
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 188
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH1

<400> 188
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
 1               5                  10                  15      
Gly Ser Ser Gly Gly Gly Ser Gly
            20                  


<210> 189
<211> 23
<212> PRT
<213> Homo sapiens

<400> 189
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro
            20              


<210> 190
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH2

<400> 190
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly
 1               5                  10                  15      
Gly Ser Ser Gly Gly Gly Ser Gly
            20                  


<210> 191
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 NH3

<400> 191
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Ala Pro Glu Leu Leu Gly Gly Pro
            20                  25  


<210> 192
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH3

<400> 192
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25          


<210> 193
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 NH4

<400> 193
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Val Glu
 1               5                  10                  15      
Cys Pro Pro Cys Ala Pro Glu Leu Leu Gly Gly Pro
            20                  25              


<210> 194
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH4

<400> 194
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Val Glu
 1               5                  10                  15      
Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  30  


<210> 195
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 NH5

<400> 195
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Pro Pro Cys Ala Pro Glu Leu Leu Gly Gly Pro
            20                  25              


<210> 196
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 EH5

<400> 196
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro
 1               5                  10                  15      
Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  30  


<210> 197
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 NH1

<400> 197
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro
            


<210> 198
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 EH1

<400> 198
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 199
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 NH2

<400> 199
Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro
            


<210> 200
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG2 EH2

<400> 200
Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 201
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH6

<400> 201
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Val Glu Cys
 1               5                  10                  15      
Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  


<210> 202
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH7

<400> 202
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15      
Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  


<210> 203
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3/IgG1 EH8

<400> 203
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys
 1               5                  10                  15      
Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
            20                  25                  30          


<210> 204
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG4 NH

<400> 204
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro
            20  


<210> 205
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG4 EH

<400> 205
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly Ser Gly
            20          


<210> 206
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 206
Glu Pro Lys Ser Cys Asp Lys Thr His Thr
 1               5                  10  


<210> 207
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 207
Glu Pro Lys Ser Ser Asp Lys Thr His Thr
 1               5                  10  


<210> 208
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 208
Glu Arg Lys
 1          


<210> 209
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 209
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr
 1               5                  10          


<210> 210
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Upper hinge

<400> 210
Glu Ser Lys Tyr Gly Pro Pro
 1               5          


<210> 211
<211> 4
<212> PRT
<213> Homo sapiens

<400> 211
Cys Pro Pro Cys
 1              


<210> 212
<211> 5
<212> PRT
<213> Homo sapiens

<400> 212
Cys Pro Pro Cys Pro
 1               5  


<210> 213
<211> 7
<212> PRT
<213> Homo sapiens

<400> 213
Cys Pro Pro Cys Pro Pro Cys
 1               5          


<210> 214
<211> 10
<212> PRT
<213> Homo sapiens

<400> 214
Cys Pro Pro Cys Val Glu Cys Pro Pro Cys
 1               5                  10  


<210> 215
<211> 10
<212> PRT
<213> Homo sapiens

<400> 215
Cys Pro Pro Cys Pro Pro Cys Pro Pro Cys
 1               5                  10  


<210> 216
<211> 9
<212> PRT
<213> Homo sapiens

<400> 216
Cys Cys Val Glu Cys Pro Pro Cys Pro
 1               5                  


<210> 217
<211> 9
<212> PRT
<213> Homo sapiens

<400> 217
Ser Cys Val Glu Cys Pro Pro Cys Pro
 1               5                  


<210> 218
<211> 7
<212> PRT
<213> Homo sapiens

<400> 218
Cys Val Glu Cys Pro Pro Cys
 1               5          


<210> 219
<211> 10
<212> PRT
<213> Homo sapiens

<400> 219
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly
 1               5                  10  


<210> 220
<211> 7
<212> PRT
<213> Homo sapiens

<400> 220
Ala Pro Pro Val Ala Gly Pro
 1               5          


<210> 221
<211> 8
<212> PRT
<213> Homo sapiens

<400> 221
Ala Pro Glu Phe Leu Gly Gly Pro
 1               5              


<210> 222
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 222
Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
 1               5                  10  


<210> 223
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 223
Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr
 1               5                  10  


<210> 224
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = C or S

<400> 224
Tyr Tyr Asp Asp His Tyr Xaa Leu Asp Tyr
 1               5                  10  


<210> 225
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 225
His Gly Arg Gly His
 1               5  


<210> 226
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 226
Trp Pro Leu Arg Phe
 1               5  


<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 227
Ala Ala Glu Gly Leu Asp Thr Gln Arg
 1               5                  


<210> 228
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 228
Ser Gln Phe Arg Val Ser Pro Leu Asp
 1               5                  


<210> 229
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 229
Ala Lys Tyr Arg Gly
 1               5  


<210> 230
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 230
Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro
 1               5                  10  


<210> 231
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 231
Pro Trp Thr His Gly
 1               5  


<210> 232
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 232
His Gly Ser Tyr Gly
 1               5  


<210> 233
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 233
Lys Arg Leu Gly Ala
 1               5  


<210> 234
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 234
His Ala Leu Leu Trp
 1               5  


<210> 235
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(2)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (4)...(5)
<223> D-amino acid

<400> 235
Leu Arg Gly Tyr Trp
 1               5  


<210> 236
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 236
Val Ala Ser His Phe
 1               5  


<210> 237
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (3)...(5)
<223> D-amino acid

<400> 237
Asn Gly Asn Val His
 1               5  


<210> 238
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 238
Arg Trp Phe Asn Val
 1               5  


<210> 239
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 239
His Ala Val Trp His
 1               5  


<210> 240
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 240
Trp Val Pro Leu Trp
 1               5  


<210> 241
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 241
Phe Phe Arg Leu Tyr
 1               5  


<210> 242
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(3)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> D-amino acid

<400> 242
Trp Tyr Tyr Gly Phe
 1               5  


<210> 243
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 243
Ala Gly Asp Ser Trp
 1               5  


<210> 244
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 244
His Val Arg His Gly
 1               5  


<210> 245
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (2)...(5)
<223> D-amino acid

<400> 245
Gly His Thr Trp Pro
 1               5  


<210> 246
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> D-amino acid

<400> 246
His Gly Arg Gly His
 1               5  


<210> 247
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 247
Thr His Pro Thr Thr
 1               5  


<210> 248
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 248
Phe Ala Gly Tyr His
 1               5  


<210> 249
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 249
Trp Thr Glu His Gly
 1               5  


<210> 250
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 250
Thr Asn Asp Phe Asp
 1               5  


<210> 251
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<400> 251
Leu Phe Pro Phe Asp
 1               5  


<210> 252
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(4)
<223> D-amino acid

<400> 252
Ser Leu Arg Phe Gly
 1               5  


<210> 253
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(3)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> D-amino acid

<400> 253
Tyr Phe Arg Gly Ser
 1               5  


<210> 254
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(4)
<223> D-amino acid

<400> 254
Trp Asn Trp Val Gly
 1               5  


<210> 255
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(4)
<223> D-amino acid

<400> 255
Val Ala Trp Leu Gly
 1               5  


<210> 256
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(4)
<223> D-amino acid

<400> 256
Phe His Val His Gly
 1               5  


<210> 257
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 257
Trp Val Ser Asn Val
 1               5  


<210> 258
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> D-amino acid

<400> 258
Trp Ser Val Asn Val
 1               5  


<210> 259
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(4)
<223> Leu Asn Ser His Gly

<400> 259
Leu Asn Ser His Gly
 1               5  


<210> 260
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (4)...(5)
<223> D-amino acid

<400> 260
Leu Asn Ser His Gly
 1               5  


<210> 261
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(4)
<223> D-amino acid

<400> 261
Asn Ser Val His Gly
 1               5  


<210> 262
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(4)
<223> D-amino acid

<400> 262
Thr Thr Val His Gly
 1               5  


<210> 263
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(3)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> D-amino acid

<400> 263
Phe Asp Val Gly His
 1               5  


<210> 264
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(2)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (4)...(5)
<223> D-amino acid

<400> 264
Arg His Gly Trp Lys
 1               5  


<210> 265
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> D-amino acid

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> D-amino acid

<400> 265
His Gly Arg Gly His
 1               5  

