                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
 
<120>  PEPTIDES THAT ENHANCE NMDA RECEPTOR FUNCTION AND USE THEREOF

<130>  8123-103479-01

<150>  US 62/942,979
<151>  2019-12-03

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1

Asn Asp Ser Tyr Leu Arg Ser Ser Leu 
1               5                   


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Leu Pro Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Pro Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr Ala 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr Ala Ser 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr Ala Ser Tyr 
1               5                   10                  15  


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Ala Asn Lys Asn Asn Met Tyr Ser Thr 
1               5                   


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser Thr Pro Arg 
1               5                   10              


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser Thr Pro Arg 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser Thr Pro Arg Val 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser Thr Pro Arg Val Leu 
1               5                   10                  15  


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Pro Arg Val Leu Asn Ser Cys Ser Asn 
1               5                   


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg 
1               5                   10      


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Asn Met Tyr Ser Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Met Tyr Ser Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Tyr Ser Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Ser Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys 
1               5                   10                  15  


<210>  21
<211>  1404
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val 
            420                 425                 430         


Trp Asn Gly Met Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala 
        435                 440                 445             


Val Gly Ser Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe 
    450                 455                 460                 


Ser Val Pro Phe Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser 
465                 470                 475                 480 


Asn Gly Thr Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser 
                485                 490                 495     


Val Trp Val Met Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala 
            500                 505                 510         


Val Phe Val Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu 
        515                 520                 525             


Ala Lys Gly Lys Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala 
    530                 535                 540                 


Ile Trp Leu Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln 
545                 550                 555                 560 


Asn Pro Lys Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe 
                565                 570                 575     


Phe Ala Val Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe 
            580                 585                 590         


Met Ile Gln Glu Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys 
        595                 600                 605             


Lys Phe Gln Arg Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr 
    610                 615                 620                 


Val Pro Asn Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr 
625                 630                 635                 640 


Met His Gln Tyr Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala 
                645                 650                 655     


Leu Val Ser Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala 
            660                 665                 670         


Ala Val Leu Asn Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val 
        675                 680                 685             


Thr Ile Gly Ser Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala 
    690                 695                 700                 


Leu Gln Lys Gly Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu 
705                 710                 715                 720 


Gln Phe Val Gly Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu 
                725                 730                 735     


Thr Gly Ile Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu 
            740                 745                 750         


Asp Ile Asp Asn Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met 
        755                 760                 765             


Ala Leu Ser Leu Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys 
    770                 775                 780                 


Leu Arg Phe Cys Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu 
785                 790                 795                 800 


Phe Ser Ile Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile 
                805                 810                 815     


Glu Glu Lys Lys Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser 
            820                 825                 830         


Asn Met Leu Lys Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser 
        835                 840                 845             


Asn Met Asn Ser Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe 
    850                 855                 860                 


Ile Gln Arg Gly Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn 
865                 870                 875                 880 


Leu Met Tyr Ser Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe 
                885                 890                 895     


Gly Asp Asn Met Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys 
            900                 905                 910         


Asp Asn Leu Asn Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu 
        915                 920                 925             


Asn Glu Ser Asn Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser 
    930                 935                 940                 


Lys Ala Asn Ser Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser 
945                 950                 955                 960 


Ile Arg Gln Asp Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu 
                965                 970                 975     


Ala Thr Ala Glu Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu 
            980                 985                 990         


Pro Glu Glu Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
        995                 1000                 1005             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1010                 1015                 1020             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1025                 1030                 1035             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1040                 1045                 1050             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1055                 1060                 1065             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1070                 1075                 1080             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1085                 1090                 1095             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1100                 1105                 1110             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1115                 1120                 1125             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1130                 1135                 1140             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1145                 1150                 1155             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1160                 1165                 1170             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1175                 1180                 1185             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1190                 1195                 1200             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1205                 1210                 1215             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1220                 1225                 1230             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1235                 1240                 1245             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1250                 1255                 1260             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1265                 1270                 1275             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1280                 1285                 1290             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1295                 1300                 1305             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1310                 1315                 1320             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1325                 1330                 1335             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1340                 1345                 1350             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1355                 1360                 1365             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1370                 1375                 1380             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1385                 1390                 1395             


Ser Ile  Glu Ser Asp Val 
    1400                 


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Ser Asn Leu Ser Asp Ser Tyr Leu Arg 
1               5                   


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  23

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
ttcaacaccc cagccatgt                                                    19


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
gcatacaggg acaacacagc c                                                 21


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
tgggcgctga cgcttact                                                     18


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
gtcagccgtg gagtcaatag c                                                 21


