                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  PEPTIDE-MHC II PROTEIN CONSTRUCTS AND USES THEREOF

<130>  057766/696193

<150>  US 62/942,344
<151>  2019-12-02

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Ser Gly Gly Gly Gly Gly 
1               5       


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Gly Ser Gly Gly Ser 
1               5   


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gly Gly Gly Ser 
1               


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Gly Gly Gly Ser 
1               5   


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gly Gly Ser Gly 
1               


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gly Gly Ser Gly Gly 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gly Ser Gly Ser Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Gly Ser Gly Gly Gly 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gly Gly Gly Ser Gly 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gly Ser Ser Ser Gly 
1               5   


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ser Gly Gly Gly Gly Gly 
1               5       


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gly Cys Gly Gly Ser 
1               5   


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Glu Asn Leu Tyr Phe Gln 
1               5       


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
1               5                   10                  15      


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            20                  25                  30          


Leu Glu Phe Ile Leu Ala Ala 
        35                  


<210>  24
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala Gln Asn 
1               5                   10                  15      


Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val Ala Gln 
            20                  25                  30          


Leu Lys Gln Lys Val Met Asn His 
        35                  40  


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp Glu Val Ile Asn 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Gly Ile Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Phe Ala 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Thr Ser Ala Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Asp Ala Gln Ser Ala Gln Ser Gln Cys Arg Thr Phe Arg Gly Arg 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Thr Phe Arg Gly Arg Val Leu Asp Met Phe Arg Thr Ala Phe Gly 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Cys Asp Met Leu Arg Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Ile Glu Gln Glu Ala Asp Asn Met Ile Thr Glu Met Leu Arg Lys 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Glu Val Lys Ser Phe Gln Trp Thr Gln Ala Leu Arg Arg Glu Leu 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Lys Asn Val Leu Lys Val Gly Arg Leu Ser Ala Glu Glu Leu Met 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Ser Glu Arg Pro Gln Ala Ser Gly Val Tyr Met Gly Asn Leu Thr 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Pro Ser Leu Thr Met Ala Cys Met Ala Lys Gln Ser Gln Thr Pro 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Glu Gly Trp Pro Tyr Ile Ala Cys Arg Thr Ser Ile Val Gly Arg 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Ser Gln Asn Arg Lys Asp Ile Lys Leu Ile Asp Val Glu Met Thr 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Gly Trp Leu Cys Lys Met His Thr Gly Ile Val Arg Asp Lys Lys 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Ser Cys Lys Ser Cys Trp Gln Lys Phe Asp Ser Leu Val Arg Cys 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  43
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Gln Lys Leu Ile Ser 
1               5                   10                  15      


Glu Glu Asp Leu His His His His His His 
            20                  25      


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Phe Pro Gln Pro Glu Gln Pro Phe Pro Trp Gln Pro 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Gln Leu 
1               5                   10          


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Gly Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  48
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu 
1               5                   10                  15      


Ile Ser Glu Glu Asp Leu His His His His His His 
            20                  25              


<210>  49
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  50
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ser Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Ser Arg Ser Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Ile Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
65                  70                  75                  80  


Ala Val Thr Leu Leu Gly Leu Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Arg Lys Arg Ala Ala Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  51
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  52
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  53
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Cys Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  54
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Ala Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Cys Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  55
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  56
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Ala Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  57
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Cys Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  58
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Cys Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  59
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Ser Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Gly Arg Lys Glu Thr Val Trp Cys Leu 
        35                  40                  45              


Pro Val Leu Arg Gln Phe Arg Phe Asp Pro Gln Phe Ala Leu Thr Asn 
    50                  55                  60                  


Ile Ala Val Leu Lys His Asn Leu Asn Ser Leu Ile Lys Arg Ser Asn 
65                  70                  75                  80  


Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser Lys 
                85                  90                  95      


Ser Pro Val Thr Leu Gly Gln Pro Asn Ile Leu Ile Cys Leu Val Asp 
            100                 105                 110         


Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly His 
        115                 120                 125             


Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp 
    130                 135                 140                 


His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Leu Leu Pro Ser Ala Glu 
145                 150                 155                 160 


Glu Ser Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Lys Pro Leu 
                165                 170                 175     


Leu Lys His Trp Glu Pro Glu Ile Pro Ala Pro Met Ser Glu Leu Thr 
            180                 185                 190         


Glu 
    


<210>  60
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
1               5                   10                  15      


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Ser Arg Ser Ile Tyr 
            20                  25                  30          


Asn Arg Glu Glu Ile Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
        35                  40                  45              


Ala Val Thr Leu Leu Gly Leu Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Ile Leu Glu Arg Lys Arg Ala Ala Val Asp Arg Val Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
                85                  90                  95      


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
    130                 135                 140                 


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
145                 150                 155                 160 


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
                165                 170                 175     


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  61
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Ala Gly Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val 
1               5                   10                  15      


Gln Thr His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp 
            20                  25                  30          


Glu Met Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu 
        35                  40                  45              


Glu Glu Phe Gly Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala 
    50                  55                  60                  


Asn Ile Ala Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser 
65                  70                  75                  80  


Asn His Thr Gln Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro 
                85                  90                  95      


Lys Glu Pro Val Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile 
            100                 105                 110         


Asp Lys Phe Phe Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly 
        115                 120                 125             


Glu Leu Val Thr Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr 
    130                 135                 140                 


Asp Tyr Ser Phe His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala 
145                 150                 155                 160 


Glu Asp Phe Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr 
            180                 185                 190         


Thr Glu 
        


<210>  62
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu 
            180                 185                 190     


<210>  63
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Ser Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Gly Arg Lys Glu Thr Val Trp Cys Leu 
        35                  40                  45              


Pro Val Leu Arg Gln Phe Arg Phe Asp Pro Gln Phe Ala Leu Thr Asn 
    50                  55                  60                  


Ile Ala Val Leu Lys His Asn Leu Asn Ser Leu Ile Lys Cys Ser Asn 
65                  70                  75                  80  


Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser Lys 
                85                  90                  95      


Ser Pro Val Thr Leu Gly Gln Pro Asn Ile Leu Ile Cys Leu Val Asp 
            100                 105                 110         


Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly His 
        115                 120                 125             


Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp 
    130                 135                 140                 


His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Leu Leu Pro Ser Ala Glu 
145                 150                 155                 160 


Glu Ser Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Lys Pro Leu 
                165                 170                 175     


Leu Lys His Trp Glu Pro Glu Ile Pro Ala Pro Met Ser Glu Leu Thr 
            180                 185                 190         


Glu 
    


<210>  64
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Ser Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Gly Arg Lys Glu Thr Val Trp Ala Leu 
        35                  40                  45              


Pro Val Leu Arg Gln Phe Arg Phe Asp Pro Gln Phe Ala Leu Thr Asn 
    50                  55                  60                  


Ile Ala Val Leu Lys His Asn Leu Asn Ser Leu Ile Lys Cys Ser Asn 
65                  70                  75                  80  


Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser Lys 
                85                  90                  95      


Ser Pro Val Thr Leu Gly Gln Pro Asn Ile Leu Ile Cys Leu Val Asp 
            100                 105                 110         


Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly His 
        115                 120                 125             


Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp 
    130                 135                 140                 


His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Leu Leu Pro Ser Ala Glu 
145                 150                 155                 160 


Glu Ser Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Lys Pro Leu 
                165                 170                 175     


Leu Lys His Trp Glu Pro Glu Ile Pro Ala Pro Met Ser Glu Leu Thr 
            180                 185                 190         


Glu 
    


<210>  65
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Ser Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Gly Arg Lys Glu Thr Val Trp Gln Leu 
        35                  40                  45              


Pro Val Leu Arg Gln Phe Arg Phe Asp Pro Gln Phe Ala Leu Thr Asn 
    50                  55                  60                  


Ile Ala Val Leu Lys His Asn Leu Asn Ser Leu Ile Lys Arg Ser Asn 
65                  70                  75                  80  


Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser Lys 
                85                  90                  95      


Ser Pro Val Thr Leu Gly Gln Pro Asn Ile Leu Ile Cys Leu Val Asp 
            100                 105                 110         


Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly His 
        115                 120                 125             


Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp 
    130                 135                 140                 


His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Leu Leu Pro Ser Ala Glu 
145                 150                 155                 160 


Glu Ser Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Lys Pro Leu 
                165                 170                 175     


Leu Lys His Trp Glu Pro Glu Ile Pro Ala Pro Met Ser Glu Leu Thr 
            180                 185                 190         


Glu 
    


<210>  66
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Ser Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Gly Arg Lys Glu Thr Val Trp Ala Leu 
        35                  40                  45              


Pro Val Leu Arg Gln Phe Arg Phe Asp Pro Gln Phe Ala Leu Thr Asn 
    50                  55                  60                  


Ile Ala Val Leu Lys His Asn Leu Asn Ser Leu Ile Lys Arg Ser Asn 
65                  70                  75                  80  


Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser Lys 
                85                  90                  95      


Ser Pro Val Thr Leu Gly Gln Pro Asn Ile Leu Ile Cys Leu Val Asp 
            100                 105                 110         


Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly His 
        115                 120                 125             


Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp 
    130                 135                 140                 


His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Leu Leu Pro Ser Ala Glu 
145                 150                 155                 160 


Glu Ser Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Lys Pro Leu 
                165                 170                 175     


Leu Lys His Trp Glu Pro Glu Ile Pro Ala Pro Met Ser Glu Leu Thr 
            180                 185                 190         


Glu 
    


<210>  67
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Ser Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Gly Arg Lys Glu Thr Val Trp Gln Leu 
        35                  40                  45              


Pro Val Leu Arg Gln Phe Arg Phe Asp Pro Gln Phe Ala Leu Thr Asn 
    50                  55                  60                  


Ile Ala Val Leu Lys His Asn Leu Asn Ser Leu Ile Lys Cys Ser Asn 
65                  70                  75                  80  


Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser Lys 
                85                  90                  95      


Ser Pro Val Thr Leu Gly Gln Pro Asn Ile Leu Ile Cys Leu Val Asp 
            100                 105                 110         


Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly His 
        115                 120                 125             


Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp 
    130                 135                 140                 


His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Leu Leu Pro Ser Ala Glu 
145                 150                 155                 160 


Glu Ser Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Lys Pro Leu 
                165                 170                 175     


Leu Lys His Trp Glu Pro Glu Ile Pro Ala Pro Met Ser Glu Leu Thr 
            180                 185                 190         


Glu 
    


<210>  68
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Cys Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu 
            180                 185                 190     


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln 
1               5                   10          


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Pro Trp 
1               5                   10          


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Phe Pro Gln Pro Glu Gln Pro Phe Pro Trp 
1               5                   10  


