                              SEQUENCE LISTING

<110> DR. MARY MORRIS & ASSOCIATES, LLC.
 
<120> METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF 
      TYPE 1 DIABETES

<130> 120177-0106

<140>
<141>

<150> 62/944,503
<151> 2019-12-06

<160> 24    

<170> PatentIn version 3.5

<210> 1
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210> 2
<211> 21
<212> PRT
<213> Homo sapiens

<400> 2
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210> 3
<211> 21
<212> PRT
<213> Homo sapiens

<400> 3
Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu 
1               5                   10                  15      


Arg Gly Phe Phe Tyr 
            20      


<210> 4
<211> 15
<212> PRT
<213> Homo sapiens

<400> 4
Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
1               5                   10                  15  


<210> 5
<211> 20
<212> PRT
<213> Homo sapiens

<400> 5
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys 
            20  


<210> 6
<211> 17
<212> PRT
<213> Homo sapiens

<400> 6
Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr 
1               5                   10                  15      


Cys 
    


<210> 7
<211> 24
<212> PRT
<213> Homo sapiens

<400> 7
Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
1               5                   10                  15      


Cys Gly Glu Arg Gly Phe Phe Tyr 
            20                  


<210> 8
<211> 24
<212> PRT
<213> Homo sapiens

<400> 8
Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys 
1               5                   10                  15      


Gly Glu Arg Gly Phe Phe Tyr Thr 
            20                  


<210> 9
<211> 20
<212> PRT
<213> Homo sapiens

<400> 9
Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg 
1               5                   10                  15      


Gly Phe Phe Tyr 
            20  


<210> 10
<211> 86
<212> PRT
<213> Homo sapiens

<400> 10
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 11
<211> 86
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Great ape insulin sequence

<400> 11
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 12
<211> 86
<212> PRT
<213> Macaca fascicularis

<400> 12
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Pro Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 13
<211> 86
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Rabbit insulin sequence

<400> 13
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ser Arg Arg 
            20                  25                  30          


Glu Val Glu Glu Leu Gln Val Gly Gln Ala Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Gly Leu Gln Pro Ser Ala Leu Glu Leu Ala Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 14
<211> 86
<212> PRT
<213> Canis sp.

<400> 14
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Arg Arg 
            20                  25                  30          


Glu Val Glu Asp Leu Gln Val Arg Asp Val Glu Leu Ala Gly Ala Pro 
        35                  40                  45              


Gly Glu Gly Gly Leu Gln Pro Leu Ala Leu Glu Gly Ala Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 15
<211> 86
<212> PRT
<213> Equus sp.


<220>
<221> MOD_RES
<222> (31)..(32)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (64)..(65)
<223> Any amino acid

<400> 15
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Xaa Xaa 
            20                  25                  30          


Glu Ala Glu Asp Pro Gln Val Gly Glu Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Leu Gly Gly Leu Gln Pro Leu Ala Leu Ala Gly Pro Gln Gln Xaa 
    50                  55                  60                  


Xaa Gly Ile Val Glu Gln Cys Cys Thr Gly Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 16
<211> 84
<212> PRT
<213> Sus scrofa

<400> 16
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Arg Arg 
            20                  25                  30          


Glu Ala Glu Asn Pro Gln Ala Gly Ala Val Glu Leu Gly Gly Gly Leu 
        35                  40                  45              


Gly Gly Leu Gln Ala Leu Ala Leu Glu Gly Pro Pro Gln Lys Arg Gly 
    50                  55                  60                  


Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
65                  70                  75                  80  


Asn Tyr Cys Asn 
                


<210> 17
<211> 86
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Hamster insulin sequence

<400> 17
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ser Arg Arg 
            20                  25                  30          


Gly Val Glu Asp Pro Gln Val Ala Gln Leu Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Asp Asp Leu Gln Thr Leu Ala Leu Glu Val Ala Gln Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Asp Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 18
<211> 86
<212> PRT
<213> Rattus sp.

<400> 18
Phe Val Lys Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Met Ser Arg Arg 
            20                  25                  30          


Glu Val Glu Asp Pro Gln Val Ala Gln Leu Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Asp Leu Gln Thr Leu Ala Leu Glu Val Ala Arg Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Asp Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 19
<211> 86
<212> PRT
<213> Mus sp.

<400> 19
Phe Val Lys Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Met Ser Arg Arg 
            20                  25                  30          


Glu Val Glu Asp Pro Gln Val Ala Gln Leu Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Asp Leu Gln Thr Leu Ala Leu Glu Val Ala Gln Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Asp Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 20
<211> 86
<212> PRT
<213> Felis sp.

<400> 20
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Gly Lys Asp Ala Glu Leu Gly Glu Ala Pro 
        35                  40                  45              


Gly Ala Gly Gly Leu Gln Pro Ser Ala Leu Glu Ala Pro Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Ala Ser Val Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu His Tyr Cys Asn 
                85      


<210> 21
<211> 86
<212> PRT
<213> Rattus sp.

<400> 21
Phe Val Lys Gln His Leu Cys Gly Pro His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ser Arg Arg 
            20                  25                  30          


Glu Val Glu Asp Pro Gln Val Pro Gln Leu Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Glu Ala Gly Asp Leu Gln Thr Leu Ala Leu Glu Val Ala Arg Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Asp Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 22
<211> 84
<212> PRT
<213> Mus sp.

<400> 22
Phe Val Lys Gln His Leu Cys Gly Pro His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ser Arg Arg 
            20                  25                  30          


Glu Val Glu Asp Pro Gln Val Glu Gln Leu Glu Leu Gly Gly Ser Pro 
        35                  40                  45              


Gly Asp Leu Gln Thr Leu Ala Leu Glu Val Ala Arg Gln Lys Arg Gly 
    50                  55                  60                  


Ile Val Asp Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
65                  70                  75                  80  


Asn Tyr Cys Asn 
                


<210> 23
<211> 81
<212> PRT
<213> Bos sp.

<400> 23
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Arg Arg 
            20                  25                  30          


Glu Val Glu Gly Pro Gln Val Gly Ala Leu Glu Leu Ala Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Gly Leu Glu Gly Pro Pro Gln Lys Arg Gly Ile Val Glu 
    50                  55                  60                  


Gln Cys Cys Ala Ser Val Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
65                  70                  75                  80  


Asn 
    


<210> 24
<211> 81
<212> PRT
<213> Ovis aries

<400> 24
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Arg Arg 
            20                  25                  30          


Glu Val Glu Gly Pro Gln Val Gly Ala Leu Glu Leu Ala Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Gly Leu Glu Gly Pro Pro Gln Lys Arg Gly Ile Val Glu 
    50                  55                  60                  


Gln Cys Cys Ala Gly Val Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
65                  70                  75                  80  


Asn 
    


