               SEQUENCE LISTING

<110> AC Immune SA

<120> Novel molecules for therapy and diagnosis

<130> AC2287 PCT

<160> 863

<170> BiSSAP 1.3.6

<210> 1
<211> 140
<212> PRT
<213> Mammalia


<220> 
<223> FL-alpha-synuclein

<400> 1
Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              
Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      
Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 

<210> 2
<211> 5
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 2
Gly Val Leu Tyr Val 
1               5   

<210> 3
<211> 7
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 3
Gly Val Ala Thr Val Ala Glu 
1               5           

<210> 4
<211> 10
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 4
Asn Val Gly Gly Ala Val Val Thr Gly Val 
1               5                   10  

<210> 5
<211> 17
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 5
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
1               5                   10                  15      
Thr 
    

<210> 6
<400> 6
000

<210> 7
<211> 8
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 7
Ala Tyr Glu Met Pro Ser Glu Glu 
1               5               

<210> 8
<211> 8
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 8
Pro Ser Glu Glu Gly Tyr Gln Asp 
1               5               

<210> 9
<211> 10
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 9
Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
1               5                   10  

<210> 10
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VH

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Ile Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Ala Asp Ser Glu Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Val Gly Leu Arg Phe Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210> 11
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VH CDR1

<400> 11
Ile Tyr Ala Met Asn 
1               5   

<210> 12
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VH CDR2

<400> 12
Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VH CDR3

<400> 13
Val Gly Leu Arg Phe Tyr Ala Met Asp Tyr 
1               5                   10  

<210> 14
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VL

<400> 14
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser Gln Gly Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         



<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VL CDR1

<400> 15
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VL CDR2

<400> 16
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VL CDR3

<400> 17
Phe Gln Gly Ser Gln Gly Pro Leu Thr 
1               5                   

<210> 18
<211> 363
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VH

<400> 18
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc      60

tcatgtgcag cctctggatt cagcttcaat atctacgcca tgaactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttatgcaaca     180

tattatgccg attcagtgaa agacagattc accatctcca gagctgattc agaaagcatg     240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtaagg     300

gtgggcctac ggttctatgc tatggactac tggggtcaag gcacctcagt caccgtctcc     360

tca                                                                   363


<210> 19
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1101C8-Ab2 1101C8F7 VL

<400> 19
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg     120

tacttgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acaaggtccg     300

ctcacgttcg gtgctgggac caagctggag ctgaaa                               336


<210> 20
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VH

<400> 20
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala His Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      
Tyr Cys Thr Ile Tyr Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ala 
        

<210> 21
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VH CDR1

<400> 21
Asp Ala Trp Met 
1               

<210> 22
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VH CDR2

<400> 22
Glu Ile Arg Asn Lys Ala His Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      
Val Lys Gly 
            

<210> 23
<400> 23
000

<210> 24
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VL

<400> 24
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Thr Lys Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Thr Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Asn Thr Val Gln Thr 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Arg Ile Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VL CDR1

<400> 25
Lys Ala Ser Gln Ser Val Thr Lys Asp Val Ala 
1               5                   10      

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VL CDR2

<400> 26
Ser Thr Ser Asn Arg Tyr Ser 
1               5           

<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VL CDR3

<400> 27
Gln Gln Asp Tyr Arg Ile Pro Tyr Thr 
1               5                   

<210> 28
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VH

<400> 28
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc      60

tcttgtgctg cctctggatt cacttttagt gacgcctgga tgaactgggt ccgccagtct     120

ccagagaagg ggcttgagtg ggttgctgaa attagaaaca aagctcataa tcatgcaaca     180

tactatgctg agtctgtgaa agggaggttc accatctcag gagatgattc caaaagtagt     240

gtctacctgc aaatgaacaa cttaagagct gaagacactg gcatttatta ctgtaccatt     300

tactcttatt ggggccaagg gactctggtc actgtctctg ca                        342


<210> 29
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1102G3-Ab1 1102G3F2 VL

<400> 29
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc      60

ataacctgca aggccagtca gagtgtgact aaagatgtag cttggtacca acagaagcca     120

gggcagtctc ctaaactgct gatatactct acatccaatc gctacagtgg agtccctgat     180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcaatac tgtgcagact     240

gaagacctgg cagtttattt ctgtcagcag gattacagga ttccgtacac gttcggaggg     300

gggaccaagc tggaaataaa a                                               321


<210> 30
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VH

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Gly Ser Asn Tyr Ala Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly His Gly Ser Ser Tyr Phe Ser Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 

<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VH CDR1

<400> 31
Thr Tyr Ala Met His 
1               5   

<210> 32
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VH CDR2

<400> 32
Arg Ile Arg Ser Lys Gly Ser Asn Tyr Ala Thr Asn Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VH CDR3

<400> 33
Gly His Gly Ser Ser Tyr Phe Ser Tyr 
1               5                   

<210> 34
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VL

<400> 34
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser His Pro Pro Thr 
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     

<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VL CDR1

<400> 35
Ser Ala Ser Ser Ser Val Ser Tyr 
1               5               

<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VL CDR2

<400> 36
Asp Thr Ser Asn Leu Ala Ser 
1               5           

<210> 37
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VL CDR3

<400> 37
Gln Gln Trp Asn Ser His Pro Pro Thr 
1               5                   

<210> 38
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VH

<400> 38
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc      60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaggtagtaa ttatgcaaca     180

aattatgccg attcagtgaa agacagattc accatctcca gagatgattc gcaaagcatg     240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgaga     300

ggacacggta gtagctactt ttcttactgg ggccaaggga ctctggtcac tgtctctgca     360


<210> 39
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1106A8-Ab2 1106A8H3 VL

<400> 39
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc      60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tccaatctgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg aatagtcacc cacccacgtt cggtgctggg     300

accaagctgg aactgaaa                                                   318


<210> 40
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VH

<400> 40
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Asn Pro Asn Asn Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ile Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VH CDR1

<400> 41
Lys Tyr Trp Met His 
1               5   

<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VH CDR2

<400> 42
Asn Ile Asn Pro Asn Asn Gly Asp Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Ser 
    

<210> 43
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VH CDR3

<400> 43
Ala Met Asp Tyr 
1               

<210> 44
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VL

<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Phe Leu Gly 
1               5                   10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Asn 
            20                  25                  30          
Leu Asn Trp Phe Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              
Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Ser Glu Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Phe Gly Ser Ser Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 45
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VL CDR1

<400> 45
Arg Ala Ser Gln Asp Ile Gly Asn Asn Leu Asn 
1               5                   10      

<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VL CDR2

<400> 46
Ala Thr Ser Ser Leu Asp Ser 
1               5           

<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VL CDR3

<400> 47
Leu Gln Phe Gly Ser Ser Pro Leu Thr 
1               5                   

<210> 48
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VH

<400> 48
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaagctg      60

tcctgcaagg cttctggcta caccttcacc aaatactgga tgcactgggt gaagcagagg     120

cctggacaag gccttgagtg gattggaaat attaatccta acaatggtga tactaactac     180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac     240

atgcagctca gcagtctgac atctgaggac tctgcggtct attattgtgc aattgctatg     300

gactactggg gtcaaggaac ctcagtcacc gtctcctca                            339


<210> 49
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1107G5-Ab2 1107G5B6 VL

<400> 49
gacatccaga tgacccagtc tccatcctcc ttatctgcct ttctgggaga aagagtcagt      60

ctcacttgtc gggcaagtca ggacattggt aataacttaa actggtttca gcaggaacca     120

gatggaacta ttaaacgtct gatctacgcc acatccagtt tagattctgg tgtccccaaa     180

aggttcagtg gcagtaggtc tgggtcagaa tattctctca ccatcagcag ccttgagtct     240

gaagattttg tagactatta ctgtctacaa tttggtagtt ctccgctcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 50
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VH

<400> 50
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala His Asn His Ala Thr Asn Tyr Ala Glu 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      
Tyr Cys Thr Ile Tyr Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ala 
        

<210> 51
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VH CDR1

<400> 51
Asp Ala Trp Met 
1               

<210> 52
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VH CDR2

<400> 52
Glu Ile Arg Asn Lys Ala His Asn His Ala Thr Asn Tyr Ala Glu Ser 
1               5                   10                  15      
Val Lys Gly 
            

<210> 53
<400> 53
000

<210> 54
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VL

<400> 54
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Thr Asn Tyr 
            20                  25                  30          
Val Ala Trp Tyr His Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Asn Thr Val Gln Thr 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Arg Ile Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 55
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VL CDR1

<400> 55
Lys Ala Ser Gln Ser Val Thr Asn Tyr Val Ala 
1               5                   10      

<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VL CDR2

<400> 56
Ser Ala Ser Asn Arg Tyr Ser 
1               5           

<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VL CDR3

<400> 57
Gln Gln Asp Tyr Arg Ile Pro Tyr Thr 
1               5                   

<210> 58
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VH

<400> 58
gaggtgaagc tggtggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc      60

tcttgtactg cctctggatt cacttttagt gacgcctgga tgaactgggt ccgccagtct     120

ccagagaagg ggcttgagtg ggttgctgaa attagaaaca aagctcataa tcatgcaaca     180

aactatgctg agtctgtgaa ggggaggttc accatctcag gagatgattc caaaagtagt     240

gtctacctgc aaatgaacaa cttaagagct gaagacactg gcatttatta ctgtaccatt     300

tactcttttt ggggccaagg gactctggtc actgtctctg ca                        342


<210> 59
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108H1-Ab1 1108H1E1 VL

<400> 59
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc      60

ataacctgca aggccagtca gagtgtgact aattatgtag cttggtacca tcagaagcca     120

gggcagtctc ctaaactgct gatatactct gcatccaatc gctacagtgg agtccctgat     180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcaatac tgtgcagact     240

gaagacctgg cagtttattt ctgtcagcag gattacagga ttccgtacac gttcggaggg     300

gggactaagc tggaaataaa a                                               321


<210> 60
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VH

<400> 60
Gln Val Gln Leu Leu Gln Pro Gly Thr Ala Leu Val Met Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Asn Pro Ile Asn Gly Gly Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Ser Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ile Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VH CDR1

<400> 61
Thr Tyr Trp Met His 
1               5   

<210> 62
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VH CDR2

<400> 62
Asn Ile Asn Pro Ile Asn Gly Gly Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Ser 
    

<210> 63
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VH CDR3

<400> 63
Ala Met Asp Tyr 
1               

<210> 64
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VL

<400> 64
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ile Ser 
            20                  25                  30          
Leu Asn Trp Phe Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              
Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  
Asn Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Phe Ala Ser Ser Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 65
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VL CDR1

<400> 65
Arg Ala Ser Gln Asp Ile Gly Ile Ser Leu Asn 
1               5                   10      

<210> 66
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VL CDR2

<400> 66
Ala Thr Ser Ser Leu Asp Ser 
1               5           

<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VL CDR3

<400> 67
Leu Gln Phe Ala Ser Ser Pro Leu Thr 
1               5                   

<210> 68
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VH

<400> 68
caggtccaac tgctgcagcc tgggactgca ctggtgatgc ctggggcttc agtgaagctg      60

tcctgcaagg cttctggcta caccttcacc acctactgga tgcactgggt gaagcagagg     120

cctggacaag gccttgagtg gattggaaat attaatccta tcaatggtgg tagtaactac     180

aatgagaagt tcaagagcaa ggcctcactg actgtagaca agtcctccag cacagcctac     240

atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgt cattgctatg     300

gactactggg gtcaaggaac ctcagtcacc gtctcctca                            339


<210> 69
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1111B12-Ab2 1111B12H10 VL

<400> 69
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt      60

ctcacatgtc gggcaagtca ggacattggt attagcttaa actggtttca gcaggaacca     120

gatggaacta ttaaacgcct gatctacgcc acatccagtt tagattctgg tgtccccaaa     180

aggttcagtg gcaataggtc tgggtcagat tattctctca ccatcagtag ccttgagtct     240

gaagattttg cagactatta ctgtctacaa tttgctagtt ctccgctcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 70
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VH

<400> 70
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Ala 
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Glu Ile Arg Asn Lys Ala His Asn Tyr Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Asp Ile Ser Gly Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      
Tyr Cys Thr Ile Tyr Ser Tyr Trp Gly Pro Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ala 
        

<210> 71
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VH CDR1

<400> 71
Asp Ala Trp Met 
1               

<210> 72
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VH CDR2

<400> 72
Glu Ile Arg Asn Lys Ala His Asn Tyr Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      
Val Lys Gly 
            

<210> 73
<400> 73
000

<210> 74
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VL

<400> 74
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Met Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Thr Met Thr Cys Thr Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Asn Thr Val Gln Thr 
65                  70                  75                  80  
Glu Asp Met Ala Val Tyr Phe Cys Gln Gln Asp Tyr Thr Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 75
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VL CDR1

<400> 75
Thr Ala Ser Gln Ser Val Ser Asn Tyr Val Ala 
1               5                   10      

<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VL CDR2

<400> 76
Ser Ala Ser Asn Arg Phe Thr 
1               5           

<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VL CDR3

<400> 77
Gln Gln Asp Tyr Thr Ser Pro Tyr Thr 
1               5                   

<210> 78
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VH

<400> 78
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc      60

tcttgtgctg cctctggatt cacttttact gacgcctgga tgaactgggt ccgccagtct     120

ccagaaaagg ggcttgagtg gattgctgaa attagaaaca aagctcataa ttatgcaaca     180

tactatgctg agtctgtgaa agggaggttc gacatctcag gagatgattc caaaagtagt     240

gtctacctgc aaatgaacaa cttgagagtt gaagacactg gcatttatta ctgtaccatt     300

tactcttact ggggcccagg gactctggtc actgtctctg ca                        342


<210> 79
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1112H8-Ab2 1112H8C12 VL

<400> 79
agtattgtga tgacccagac tcccaaattc ctgcttatgt caccaggaga cagggttacc      60

atgacctgca cggccagtca gagtgtgagt aattatgtgg cttggtacca acagaagcca     120

gggcagtctc ctaaactgct gatatactct gcatccaatc gcttcactgg agtccctgat     180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcaacac tgtgcagact     240

gaagacatgg cagtttattt ctgtcagcag gattacacct ctccgtacac gttcgggggg     300

gggaccaagc tggaaataaa a                                               321


<210> 80
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VH

<400> 80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Gly Ser Asn Tyr Ala Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly His Gly Ser Ser Tyr Phe Ser Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 

<210> 81
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VH CDR1

<400> 81
Thr Tyr Ala Met His 
1               5   

<210> 82
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VH CDR2

<400> 82
Arg Ile Arg Ser Lys Gly Ser Asn Tyr Ala Thr Asn Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VH CDR3

<400> 83
Gly His Gly Ser Ser Tyr Phe Ser Tyr 
1               5                   

<210> 84
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VL

<400> 84
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ile Thr Met Thr Cys Ser Ala Asn Ser Ser Val Thr Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Lys Ser His Pro Pro Thr 
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     

<210> 85
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VL CDR1

<400> 85
Ser Ala Asn Ser Ser Val Thr Tyr Met His 
1               5                   10  

<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VL CDR2

<400> 86
Asp Thr Ser Asn Leu Ala Ser 
1               5           

<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VL CDR3

<400> 87
Gln Gln Trp Lys Ser His Pro Pro Thr 
1               5                   

<210> 88
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VH

<400> 88
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc      60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaggtagtaa ttatgcaaca     180

aattatgccg attcagtgaa agacagattc accatctcca gagatgattc gcaaagcatg     240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgaga     300

ggacacggta gtagctactt ttcttactgg ggccaaggga ctctggtcac tgtctctgca     360


<210> 89
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1108B11-Ab2 1108B11D3 VL

<400> 89
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaggatcacc      60

atgacctgca gtgccaactc aagtgttact tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tccaatctgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg aaaagtcacc cacccacgtt cggtgctggg     300

accaagctgg aactgaaa                                                   318


<210> 90
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VH

<400> 90
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Gly Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Gly Val Ser Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser 
        115                 

<210> 91
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VH CDR1

<400> 91
Thr Tyr Ala Leu His 
1               5   

<210> 92
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VH CDR2

<400> 92
Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 93
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VH CDR3

<400> 93
Gly Gly Val Ser Pro Phe Asp Tyr 
1               5               

<210> 94
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VL

<400> 94
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 95
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VL CDR1

<400> 95
Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  

<210> 96
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VL CDR2

<400> 96
Asp Thr Ser Lys Leu Ala Ser 
1               5           

<210> 97
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VL CDR3

<400> 97
Gln Gln Trp Ser Asn Asn Pro Pro Thr 
1               5                   

<210> 98
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VH

<400> 98
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc      60

tcatgtgccg cctctggttt caccttcaat acctatgccc tgcactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtagtaa ttatgcaaca     180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagcatg     240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag gcatgtatta ctgtgtaaga     300

gggggtgttt ctccctttga ctactggggc caaggcacca ctctcacagt ctcctca        357


<210> 99
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1113D10-Ab1 1113D10E3D5 VL

<400> 99
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc      60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa     240

gattctgcca cttattactg ccagcagtgg agtaataacc caccgacgtt cggtggaggc     300

accaagctgg aaatcaaa                                                   318


<210> 100
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VH

<400> 100
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Phe Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Arg Gly 
            20                  25                  30          
Phe Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Asp Asp Gly Asn Ser Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Phe Lys Asn Gln Val Phe 
65                  70                  75                  80  
Leu Arg Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Leu Leu Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 101
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VH CDR1

<400> 101
Arg Gly Phe Tyr Trp Asn 
1               5       

<210> 102
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VH CDR2

<400> 102
Tyr Ile Ser Asp Asp Gly Asn Ser Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      



<210> 103
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VH CDR3

<400> 103
Gly Asp Leu Leu 
1               

<210> 104
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VL

<400> 104
Asp Val Val Met Thr Gln Thr Ala Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 105
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VL CDR1

<400> 105
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Glu Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 106
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VL CDR2

<400> 106
Leu Val Ser Lys Leu Asp Ser 
1               5           

<210> 107
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VL CDR3

<400> 107
Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   

<210> 108
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VH

<400> 108
gatgtacaac ttcaggagtc aggacctggc ttcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggcta ctcaataacc agaggttttt actggaactg gatccgacag     120

tttccaggaa acaaactgga atggatgggc tacataagtg acgatggtaa tagtaactac     180

aatccctctc tcaaaaatcg aatctccatc actcgtgaca catttaagaa tcaggttttc     240

ctgaggttga actctgtgac tactgaggac actgccacat actattgtac aagaggagat     300

ctactttggg gccaaggcac cactctcaca gtctcctca                            339


<210> 109
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1116F2-Ab1 1116F2A2 VL

<400> 109
gatgttgtga tgacccagac tgcactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca aagcctctta gatagtgatg gagagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggtagt ggatcaggga cagatttcgc actgaaaatc     240

agcagagtgg aggctgagga cttgggaatt tattattgct ggcaaggtac acattttcct     300

cagacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 110
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VH

<400> 110
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Val Ile Ser Trp Val Lys Gln Gly Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Tyr Pro Gly Asn Asp Ser Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Glu Gly Val Ser Asn Gly Tyr Leu Tyr Leu Ser Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             

<210> 111
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VH CDR1

<400> 111
Asp Tyr Val Ile Ser 
1               5   

<210> 112
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VH CDR2

<400> 112
Glu Ile Tyr Pro Gly Asn Asp Ser Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 113
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VH CDR3

<400> 113
Glu Gly Val Ser Asn Gly Tyr Leu Tyr Leu Ser Met Asp Tyr 
1               5                   10                  

<210> 114
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VL

<400> 114
Asp Val Leu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      
Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 115
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VL CDR1

<400> 115
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 116
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VL CDR2

<400> 116
Leu Val Ser Lys Leu Asp Ser 
1               5           

<210> 117
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VL CDR3

<400> 117
Val Gln Gly Thr His Phe Pro Trp Thr 
1               5                   

<210> 118
<211> 369
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VH

<400> 118
caggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg      60

tcctgcaagg cttctggata cacattcact gactatgtta taagctgggt gaagcaggga     120

actggacagg gccttgagtg gattggagag atttatcctg gaaatgatag tacttactac     180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccaa cacagcctac     240

atgcagctca gcagcctgac atctgaggac tctgcggtct atttctgtgc aagagagggg     300

gtctctaatg gttacctata tttgtctatg gactactggg gtcaaggaac ctcagtcacc     360

gtctcctca                                                             369


<210> 119
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-1206E5-Ab1 1206E5D2 VL

<400> 119
gatgttttga tgacccaaac tccactcact ttgtcggtta ccattggaca accagcctct      60

atctcttgca agtcaagtca gagcctctta tatagtaatg gaaaaaccta tttgaattgg     120

ttattacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggaa cagattttac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattactgcg tgcaaggtac acattttccg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 120
<211> 14
<212> PRT
<213> Mammalia


<220> 
<223> Artificial peptide

<400> 120
Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly 
1               5                   10                  

<210> 121
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 121
Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val 
1               5                   10                  15  

<210> 122
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial peptide

<400> 122
Lys Ala Lys Glu Gly Val Val Ala Ala Ala Glu Lys Thr Lys Gln 
1               5                   10                  15  

<210> 123
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial Peptide

<400> 123
Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys Thr 
1               5                   10                  15  

<210> 124
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial Peptide

<400> 124
Glu Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser 
1               5                   10                  15  

<210> 125
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial Peptide

<400> 125
Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val Val His Gly 
1               5                   10                  15  

<210> 126
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial Peptide

<400> 126
Glu Gly Val Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys 
1               5                   10                  15  

<210> 127
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial Peptide

<400> 127
Val Ala Glu Lys Thr Lys Glu Gln Val Thr Asn Val Gly Gly Ala 
1               5                   10                  15  

<210> 128
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 128
Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala 
1               5                   10                  15  

<210> 129
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial peptide

<400> 129
Gly Val Thr Ala Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser 
1               5                   10                  15  

<210> 130
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 130
Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
1               5                   10                  15  

<210> 131
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 131
Ala Thr Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu 
1               5                   10                  15  

<210> 132
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial Peptide

<400> 132
Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile Leu Glu 
1               5                   10                  15  

<210> 133
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Artificial Peptide

<400> 133
Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu 
1               5                   10                  15  

<210> 134
<211> 15
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 134
Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly 
1               5                   10                  15  

<210> 135
<211> 14
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 135
Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
1               5                   10                  

<210> 136
<211> 8
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 136
Gly Val Ala Thr Val Ala Glu Lys 
1               5               

<210> 137
<211> 40
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 137
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
1               5                   10                  15      
Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            20                  25                  30          
Leu Glu Asp Met Pro Val Asp Pro 
        35                  40  

<210> 138
<211> 31
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 138
Val Val Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala 
1               5                   10                  15      
Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys 
            20                  25                  30      

<210> 139
<211> 23
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 139
Glu Ala Ala Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys 
1               5                   10                  15      
Thr Lys Glu Gly Val Val His 
            20              

<210> 140
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501G2-Ab2 2501G2E5 VH

<400> 140
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Thr Lys Ser Asn Asn Phe Ala Thr Tyr Tyr Ala His 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gln Gly Leu Ala Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210> 141
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501G2-Ab2 2501G2E5 VH CDR1

<400> 141
Thr Tyr Ala Met Asn 
1               5   

<210> 142
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501G2-Ab2 2501G2E5 VH CDR2

<400> 142
Arg Ile Arg Thr Lys Ser Asn Asn Phe Ala Thr Tyr Tyr Ala His Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 143
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501G2-Ab2 2501G2E5 VH CDR3

<400> 143
Gln Gly Leu Ala Tyr Tyr Ala Met Asp Tyr 
1               5                   10  

<210> 144
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501G2-Ab2 2501G2E5 VL

<400> 144
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser Gln Gly Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         



<210> 145
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501G2-Ab2 2501G2E5 VL CDR1

<400> 145
Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 146
<211> 30
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 146
Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu 
1               5                   10                  15      
Gly Val Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys 
            20                  25                  30  

<210> 147
<211> 45
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 147
Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly 
1               5                   10                  15      
Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met 
            20                  25                  30          
Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
        35                  40                  45  

<210> 148
<211> 363
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501G2-Ab2 2501G2E5 VH

<400> 148
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc      60

tcatgtgcag cctctggatt caacttcaat acctatgcca tgaactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaacta aaagtaataa ttttgcaaca     180

tattatgccc attcagtgaa agacagattc accatctcca gagatgattc agaaagcatg     240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgaga     300

cagggactag cctactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc     360

tca                                                                   363


<210> 149
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501G2-Ab2 2501G2E5 VL

<400> 149
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagtctcc      60

atctcttgca gatctagtca aaccattgta catagtaatg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acaaggtccg     300

ctcacgttcg gtgctgggac caaactggag ctgaaa                               336


<210> 150
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VH

<400> 150
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Leu Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Leu Gly Tyr Ile Asn Tyr Asp Gly Ser Asn Asn Phe Asn Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Lys Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Leu Arg Gly Asp Trp Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ala 
    

<210> 151
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VH CDR1

<400> 151
Ser Gly Tyr Tyr Trp Asn 
1               5       

<210> 152
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VH CDR2

<400> 152
Tyr Ile Asn Tyr Asp Gly Ser Asn Asn Phe Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      



<210> 153
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VH CDR3

<400> 153
Gly Asp Trp Asp 
1               

<210> 154
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VL

<400> 154
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Cys Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         



<210> 155
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VL CDR1

<400> 155
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Glu Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 156
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VL CDR2

<400> 156
Leu Val Ser Lys Leu Asp Ser 
1               5           

<210> 157
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VL CDR3

<400> 157
Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   

<210> 158
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VH

<400> 158
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccgacta     120

tttccaggaa acaaactgga atggctgggc tacataaact acgatggtag caataacttc     180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc     240

ctgaaattga attctgtgac ttctgaggac acagccacat atttctgttt aagaggggac     300

tgggactggg gccaagggac tctggtcact gtctctgca                            339


<210> 159
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2503C6-Ab1 2503C6H9 VL

<400> 159
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gagagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct gtctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cagacgttcg gtggaggcac caggctggaa atcaaa                               336


<210> 160
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VH

<400> 160
Gln Val Gln Leu Gln Gln Ser Gly Val Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Lys Trp Ile 
        35                  40                  45              
Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Thr Asp Tyr Asp Ala Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 161
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VH CDR1

<400> 161
Ser Tyr Gly Ile Ser 
1               5   

<210> 162
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VH CDR2

<400> 162
Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 163
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VH CDR3

<400> 163
Asp Tyr Asp Ala Tyr 
1               5   

<210> 164
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VL

<400> 164
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         



<210> 165
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VL CDR1

<400> 165
Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      



<210> 166
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VL CDR2

<400> 166
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 167
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VL CDR3

<400> 167
Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   

<210> 168
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VH

<400> 168
caggttcagc tgcagcagtc tggagttgag ctggcgaggc ctggggcttc agtgaaactg      60

tcctgcaagg cttctggcta caccttcaca agctatggta taagctgggt gaagcagaga     120

actggacagg gccttaagtg gattggagag atttatcctg gaagtggtaa tacttactac     180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac     240

atggagctcc gcagcctgac gtctgaggac tctgcggtct atttctgtgc aaccgattac     300

gacgcctact ggggccaagg caccactctc acagtctcct ca                        342


<210> 169
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2504A6-Ab1 2504A6C8 VL

<400> 169
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg     120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg     300

ctcacgttcg gtgctgggac caagctggag ctgaaa                               336


<210> 170
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VH

<400> 170
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Ser 
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Tyr Tyr Asp Gly Lys Phe 
    50                  55                  60                  
Lys Gly Lys Val Lys Leu Thr Thr Asp Lys Phe Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Trp Gly Gly Thr Asn Asp Glu Trp Phe Ala His Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Val 
        115                 120 

<210> 171
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VH CDR1

<400> 171
Asn Ser Trp Met Asn 
1               5   

<210> 172
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VH CDR2

<400> 172
Arg Ile Phe Pro Gly Asp Gly Asp Thr Tyr Tyr Asp Gly Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 173
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VH CDR3

<400> 173
Trp Gly Gly Thr Asn Asp Glu Trp Phe Ala His 
1               5                   10      

<210> 174
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VL

<400> 174
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          
Arg Asn Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Arg Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      
Asp Ile Pro Leu Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Ser 
            100                 105                 110     

<210> 175
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VL CDR1

<400> 175
Arg Ala Ser Gln Ser Val Ser Thr Ser Arg Asn Ser Tyr Met His 
1               5                   10                  15  

<210> 176
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VL CDR2

<400> 176
Tyr Ala Ser Asn Leu Glu Ser 
1               5           

<210> 177
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VL CDR3

<400> 177
Gln His Ser Trp Asp Ile Pro Leu Thr 
1               5                   

<210> 178
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VH

<400> 178
caggttcagt tgcagcagtc tggacctgag ctggtgaggc ctggggcctc agtgaagatt      60

tcctgcaagg cttctggcta cgcattcagt aactcctgga tgaactgggt gaagcagagg     120

cctggaaagg gtcttgagtg gattggacgg atttttcctg gagatggaga tacttactac     180

gatgggaagt tcaagggcaa ggtcaaactg acaacagaca aattctccaa cacagcctac     240

atgcaactcc gcagcctgac atctgaggac tctgcggtct acttctgtgc aagatggggg     300

ggtactaacg atgagtggtt tgctcactgg ggccaaggga ctctggtcac tgtctctgta     360


<210> 179
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506E2-Ab2 2506E2G4 VL

<400> 179
gacattgtgc tgacacagtc tcctgcttcc ttaactgtat ctctggggca gagggccacc      60

atctcatgca gggccagcca aagtgtcagt acatctagga atagttatat gcactggtac     120

caacagaaac caagacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct     180

ggggtccctg ccaggttcag tggcagtggg tctggggcag acttcaccct caacatccat     240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga tattccgctc     300

acgttcggta ctgggaccaa gctggagctg agt                                  333


<210> 180
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VH

<400> 180
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          
Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ile Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Met Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 181
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VH CDR1

<400> 181
Thr Tyr Trp Met Gln 
1               5   

<210> 182
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VH CDR2

<400> 182
Glu Ile Asp Pro Ser Asp Ser Tyr Ile Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 183
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VH CDR3

<400> 183
Gly Met Met Asp Tyr 
1               5   

<210> 184
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VL

<400> 184
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Lys Gly 
                85                  90                  95      
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 185
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VL CDR1

<400> 185
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 186
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VL CDR2

<400> 186
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 187
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VL CDR3

<400> 187
Phe Lys Gly Ser His Val Pro Tyr Thr 
1               5                   

<210> 188
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VH

<400> 188
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagctg      60

tcctgcaagg cttctggcta caccttcacc acctactgga tgcagtgggt aaaacagagg     120

cctggacagg gccttgagtg gatcggagag attgatcctt ctgatagcta tattaactac     180

aatcaaaagt tcaagggcaa ggccacattg actgtagaca catcctccag cacagccttc     240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagggggatg     300

atggactact ggggtcaagg aacctcagtc accgtctcct ca                        342


<210> 189
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2506F3-Ab1 2506F3E12 VL

<400> 189
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttaaaggttc acatgttccg     300

tacacgttcg gaggggggac caagctggaa ataaaa                               336


<210> 190
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VH

<400> 190
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Thr Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Glu Asn Ser Asn Phe Ala Lys Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met His Thr Leu Lys Thr Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Tyr Asn Gly Ser Ser Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 

<210> 191
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VH CDR1

<400> 191
Thr Tyr Ala Met His 
1               5   

<210> 192
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VH CDR2

<400> 192
Arg Ile Arg Ser Glu Asn Ser Asn Phe Ala Lys Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 193
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VH CDR3

<400> 193
Gly Tyr Asn Gly Ser Ser Leu Asp Tyr 
1               5                   

<210> 194
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VL

<400> 194
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Gly 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 195
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VL CDR1

<400> 195
Ser Ala Ser Ser Ser Val Asn Tyr Met His 
1               5                   10  

<210> 196
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VL CDR2

<400> 196
Asp Thr Ser Lys Leu Ala Ser 
1               5           

<210> 197
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VL CDR3

<400> 197
Gln Gln Trp Arg Ser Asn Pro Pro Thr 
1               5                   

<210> 198
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VH

<400> 198
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaagtc      60

tcatgtgccg cctctggttt caccttcaag acctatgcca tgcactgggt ccgccaggct     120

ccgggaaagg gtttggaatg ggttgctcgc ataagaagtg aaaacagtaa ttttgcaaaa     180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagtatg     240

ctctatctgc aaatgcacac cctgaaaact gaggacacag ccatctatta ttgtgtaagg     300

ggatataacg gcagtagcct tgactactgg ggccaaggca ccactctcac agtctcctca     360


<210> 199
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2507B3-Ab1 2507B3G8 VL

<400> 199
caaattgttc tcacccagtc tccagcaatc atgtctgcat ttccagggga gagggtcacc      60

atgacctgca gtgccagctc aagtgtaaat tacatgcact ggtaccagca gaagtccggc     120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggcg gtgggtctgg gacctcttac tctctcacaa tcagcaacat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg agaagtaatc cacccacttt cggagggggg     300

accaagctgg aaataaaa                                                   318


<210> 200
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3 2511B3B12 VH

<400> 200
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Phe Ser Ile Thr Ser Tyr 
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asp Trp Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ala 
    

<210> 201
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3 2511B3B12 VH CDR1

<400> 201
Ser Tyr Tyr Tyr Trp Asn 
1               5       

<210> 202
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3 2511B3B12 VH CDR2

<400> 202
Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      



<210> 203
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3 2511B3B12 VH CDR3

<400> 203
Gly Asp Trp Asp 
1               

<210> 204
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3 2511B3B12 VL

<400> 204
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Leu Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 205
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3 2511B3B12 VL CDR1

<400> 205
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Glu Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 206
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3 2511B3B12 VL CDR2

<400> 206
Leu Val Ser Lys Leu Glu Ser 
1               5           

<210> 207
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3 2511B3B12 VL CDR3

<400> 207
Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   

<210> 208
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3- 2511B3B12 VH

<400> 208
gatgtacagc ttcaggaatc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggctt ctccatcacc agttattatt actggaactg gatccggcag     120

tttccaggaa acaaactgga atggatggcc tacataagct acgatggtag caataactac     180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc     240

ctgaagttga attctgtgac tactgaggac acagccacat attactgtac aagaggggac     300

tgggactggg gccaagggac tctggtcact gtctctgca                            339


<210> 209
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2511B3-Ab3- 2511B3B12 VL

<400> 209
gatgttgtga tgacccagac tccactcact ttgtcgctta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gagagacata tttgaattgg     120

ttgttacaga ggccaggtca gtctccaaag cgcctaatct atctggtgtc taaactggaa     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagttttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaagggac acattttcct     300

cagacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 210
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VH

<400> 210
Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Asp Tyr Ala Ser Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu His Leu Ser Ser Leu Thr Ser Glu Asp Ala Ala Val Tyr Phe Cys 
                85                  90                  95      
Thr Thr Arg Gly Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser 
    

<210> 211
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VH CDR1

<400> 211
Asp Asp Tyr Ile His 
1               5   

<210> 212
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VH CDR2

<400> 212
Trp Ile Asp Pro Glu Asn Gly Asp Thr Asp Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 213
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VH CDR3

<400> 213
Arg Gly Phe Gly Tyr 
1               5   

<210> 214
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VL

<400> 214
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Asn Val 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 215
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VL CDR1

<400> 215
Lys Ala Ser Gln Asp Val Gly Asn Val Val Ala 
1               5                   10      

<210> 216
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VL CDR2

<400> 216
Trp Ala Ser Ser Arg His Thr 
1               5           

<210> 217
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VL CDR3

<400> 217
Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   

<210> 218
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VH

<400> 218
gagattcaac tgcagcagtc tggggctgag cttgtgaggc caggggcctc agtcaagttg      60

tcctgcacaa cttccggctt taacattaaa gacgactata ttcactgggt gaagcagagg     120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgattat     180

gcctcgaagt tccagggcaa ggccactata acagcagaca catcctccaa cacagcctac     240

ctgcacctca gcagcctgac atcagaggac gctgccgtct atttctgtac tacaagagga     300

tttggttact ggggccaagg gactctggtc actgtctct                            339


<210> 219
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2601B6-Ab1 2601B6D2 VL

<400> 219
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      60

atcacctgca aggccagtca ggatgtgggt aatgttgttg cctggtatca acagaaacca     120

ggacaatctc ctaaactact gatttactgg gcatcctccc ggcacactgg agtccctgat     180

cgcttcacag gcagtggatc tgggacagaa ttcactctca ccattagcaa tgtgcagtct     240

gaagacttgg cagattattt ctgtcagcaa tatagcagct atccgctcac gttcggtgct     300

gggaccaagc tggagctgaa g                                               321


<210> 220
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VH

<400> 220
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Thr Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Gly Ser Asp Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Phe Cys Val Arg Gly Gly Ala Asp Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Thr 
        115                 120 

<210> 221
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VH CDR1

<400> 221
Thr Tyr Ala Met His 
1               5   

<210> 222
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VH CDR2

<400> 222
Arg Ile Arg Ser Lys Gly Ser Asp Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 223
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VH CDR3

<400> 223
Gly Gly Ala Asp Ser Trp Phe Ala Tyr 
1               5                   

<210> 224
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VL

<400> 224
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ile Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Ala Ser Tyr Thr Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Arg Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Gln Leu Ala Ile Lys 
            100                 105     

<210> 225
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VL CDR1

<400> 225
Thr Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  

<210> 226
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VL CDR2

<400> 226
Asp Thr Ser Lys Leu Ala Ser 
1               5           

<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VL CDR3

<400> 227
Gln Gln Trp Asn Arg Asn Pro Pro Thr 
1               5                   

<210> 228
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VH

<400> 228
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc      60

tcatgtgccg cctctggttt caccttcaag acctatgcca tgcactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaggtagtga ttatgcaaca     180

tattatgccg attcagtgaa ggacagattc accatctcca gagatgattc acaaagcatg     240

ctctatctgc aaatgaacaa cctgaaaact gaggatacag ccatgtattt ctgtgtgaga     300

gggggtgctg actcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctaca     360


<210> 229
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2602G4-Ab4 2602G4H1 VL

<400> 229
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaggatcacc      60

atgacctgca ctgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg ggcctcttat actctcacaa tcagcagcat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg aatcgtaacc caccgacgtt cggtggaggc     300

acccagctgg caatcaaa                                                   318


<210> 230
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VH

<400> 230
Gln Val Gln Leu Gln Gln Pro Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met Gln Trp Thr Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Tyr Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Leu Tyr Asp Gly Pro Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser 
        

<210> 231
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VH CDR1

<400> 231
Ser Tyr Trp Met Gln 
1               5   

<210> 232
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VH CDR2

<400> 232
Glu Ile Asp Pro Ser Asp Ser Tyr Ala Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 233
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VH CDR3

<400> 233
Tyr Asp Gly Pro Ser Tyr 
1               5       

<210> 234
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VL

<400> 234
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Gly Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Pro Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 235
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VL CDR1

<400> 235
Ser Ala Gly Ser Ser Val Ser Tyr Met His 
1               5                   10  

<210> 236
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VL CDR2

<400> 236
Asp Thr Ser Lys Leu Pro Ser 
1               5           

<210> 237
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VL CDR3

<400> 237
Phe Gln Gly Ser Gly Tyr Pro Tyr Thr 
1               5                   

<210> 238
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VH

<400> 238
caggtccaac tgcagcaacc tggggctgac cttgtgaagc ctggggcttc agtgaagctg      60

tcctgtaagg cttctggcta caccttcacc agttactgga tgcagtggac aaaacagagg     120

cctggacagg gccttgagtg gatcggagag attgatcctt ctgatagcta tgctaactac     180

aatcaaaagt tcaagggcaa ggccacattg actgttgaca aatattccag cacagcctac     240

atgcagctca acagcctgac atctgaggac tctgcggtct attactgtgc cctctatgat     300

ggtccctctt actggggcca agggactctg gtcactgtct ct                        342


<210> 239
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603C1-Ab3 2603C1H6 VL

<400> 239
gaaaatgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga aaaggtcacc      60

atgacctgca gtgccggctc aagtgtaagt tacatgcact ggttccaaca gaagtcaagc     120

acctccccca aactctggat ttatgacaca tccaaactgc cttctggagt cccaggtcgc     180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa     240

gatgttgcca cttattactg ttttcagggg agtgggtacc cgtacacgtt cggagggggg     300

accaagctgg aaataaaa                                                   318


<210> 240
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VH

<400> 240
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Gly Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Gly Gly Asp Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 

<210> 241
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VH CDR1

<400> 241
Thr Tyr Ala Met His 
1               5   

<210> 242
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VH CDR2

<400> 242
Arg Ile Arg Ser Lys Gly Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VH CDR3

<400> 243
Gly Gly Gly Asp Ser Trp Phe Ala Tyr 
1               5                   

<210> 244
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VL

<400> 244
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Ala Ser Tyr Thr Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Gln Leu Ala Ile Lys 
            100                 105     

<210> 245
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VL CDR1

<400> 245
Thr Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  

<210> 246
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VL CDR2

<400> 246
Asp Thr Ser Lys Leu Ala Ser 
1               5           

<210> 247
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VL CDR3

<400> 247
Gln Gln Trp Asn Ser Asn Pro Pro Thr 
1               5                   

<210> 248
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VH

<400> 248
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc      60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaggtagtaa ttatgcaaca     180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagcatg     240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgaga     300

gggggtggtg actcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca     360


<210> 249
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2603F3-Ab1 2603F3H3 VL

<400> 249
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gagggtcacc      60

atgacctgca ctgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg ggcctcttat actctcacaa tcagcagcat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg aatagtaacc caccgacgtt cggtggaggc     300

acccagctgg caatcaaa                                                   318


<210> 250
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VH

<400> 250
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Lys Thr Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Gly Gly Asn Tyr Ala Thr Tyr Phe Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Asn Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Val Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Phe Cys Val Arg Gly Gly Asn Tyr Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 

<210> 251
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VH CDR1

<400> 251
Thr Tyr Ala Met His 
1               5   

<210> 252
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VH CDR2

<400> 252
Arg Ile Arg Ser Lys Gly Gly Asn Tyr Ala Thr Tyr Phe Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 253
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VH CDR3

<400> 253
Gly Gly Asn Tyr Ser Trp Phe Ala Tyr 
1               5                   

<210> 254
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VL

<400> 254
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Gln Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser His Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Arg Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Ala Ile Lys 
            100                 105     

<210> 255
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VL CDR1

<400> 255
Ser Ala Ser Ser Ser Val Thr Tyr Met His 
1               5                   10  

<210> 256
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VL CDR2

<400> 256
Asp Thr Ser Gln Leu Ala Ser 
1               5           

<210> 257
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VL CDR3

<400> 257
Gln Gln Trp Thr Arg Asn Pro Pro 
1               5               

<210> 258
<211> 360
<212> DNA
<213> Mammalia


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VH

<400> 258
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc      60

tcatgtgccg cctctggttt catctttaaa acctatgcca tgcattgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcga ataagaagta aaggtggtaa ttatgcaaca     180

tattttgccg attcagtgaa agacagattc accatctcca gagatgattc acaaaatatg     240

ctctatctgc aagtgaacaa cctgaaaatt gaggacacag ccatgtattt ctgtgtgaga     300

gggggtaatt actcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca     360


<210> 259
<211> 318
<212> DNA
<213> Mammalia


<220> 
<223> ACI-7079-2605B3-Ab2 2605B3D1 VL

<400> 259
caaattgttc tcacccagtc tccagcaatc atgtctgctt ctccagggga gaaggtcacc      60

atgacctgca gtgccagctc aagtgtaact tacatgcatt ggtaccagca gaagtcaggc     120

acctccccca aaagatggat ttatgacaca tcccaactgg cttctggagt ccctgctcgc     180

ttcagtggca gtgggtctgg gacctctcac tctctcacaa tcagcagcat ggagactgaa     240

gatgctgcca cttattactg ccaacaatgg actagaaacc caccgacgtt cggtggaggc     300

accaagctgg caatcaaa                                                   318


<210> 260
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VH

<400> 260
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Ala Phe Ser Ser Ser 
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asn Tyr Asp Arg Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Trp Thr Gly Gly Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala 
        115                 

<210> 261
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VH CDR1

<400> 261
Ser Ser Trp Met Asn 
1               5   

<210> 262
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VH CDR2

<400> 262
Arg Ile Phe Pro Gly Asp Gly Asp Thr Asn Tyr Asp Arg Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210> 263
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VH CDR3

<400> 263
Trp Thr Gly Gly Tyr Asp Trp Phe Ala Tyr 
1               5                   10  

<210> 264
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VL

<400> 264
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          
Asn Tyr Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Thr Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Gly Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      
Glu Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     

<210> 265
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VL CDR1

<400> 265
Arg Ala Ser Gln Ser Val Ser Thr Ser Asn Tyr Asn Tyr Leu His 
1               5                   10                  15  

<210> 266
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VL CDR2

<400> 266
Tyr Ala Ser Asn Leu Glu Ser 
1               5           

<210> 267
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VL CDR3

<400> 267
Gln His Ser Trp Glu Ile Pro Leu Thr 
1               5                   

<210> 268
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VH

<400> 268
caggttcagc tgcaacagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt      60

tcctgcaagg cttctggctt cgcattcagt agctcctgga tgaactgggt gaagcagagg     120

cctggaaagg gtcttgagtg ggttggacgg atttttcctg gagatggaga tactaactac     180

gataggaagt tcaaggacaa ggccacactg actgcagaca aatcctccag cacagcctac     240

atgcaactca gcagcctgac atctgaggac tctgcggtct acttctgtgc aagatggacg     300

gggggttacg actggtttgc ttactggggc caagggactc tggtcactgt ctctgca        357


<210> 269
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2606A6-Ab2 2606A6D5 VL

<400> 269
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc      60

atctcatgca gggccagcca aagtgtcagt acatctaact ataattatct tcactggtac     120

caacagaaac caggacagcc acccaaactc ctcatcacgt atgcatccaa cctagaatct     180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat     240

cctgtggagg agggagatac tgcaacatat tactgtcaac acagttggga gattccgctc     300

acgttcggtg ctgggaccaa gctggagctg aaa                                  333


<210> 270
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VH

<400> 270
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Leu Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          
Asn Met His Trp Val Lys Gln Ser Arg Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Ile Asn Pro Asn Asn Gly Val Pro Thr Tyr Lys Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Val Asn Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Ile Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Gly Asp His Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ala 
        115         

<210> 271
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VH CDR1

<400> 271
Asp Tyr Asn Met His 
1               5   

<210> 272
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VH CDR2

<400> 272
Tyr Ile Asn Pro Asn Asn Gly Val Pro Thr Tyr Lys Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 273
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VH CDR3

<400> 273
Gly Gly Asp His Arg Phe Ala Tyr 
1               5               

<210> 274
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VL

<400> 274
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          
Gly Phe Ser Phe Val Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Lys Gly Ser Gly Val Pro Val 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Ser Ile His 
65                  70                  75                  80  
Pro Met Glu Ala Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Asn Lys 
                85                  90                  95      
Glu Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     

<210> 275
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VL CDR1

<400> 275
Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Phe Ser Phe Val Asn 
1               5                   10                  15  

<210> 276
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VL CDR2

<400> 276
Ser Ala Ser Tyr Lys Gly Ser 
1               5           

<210> 277
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VL CDR3

<400> 277
Gln Gln Asn Lys Glu Val Pro Leu Thr 
1               5                   

<210> 278
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VH

<400> 278
gaggtccagc tgcaacagtc tggacctgaa ctggtgaagc ctggggcttc gctgaagatg      60

tcctgcaagg cttctggata ctcattcact gactacaaca tgcactgggt gaaacagagc     120

cgtggaaaga gccttgagtg gattggatat attaacccta acaatggtgt tcccacgtat     180

aagcagaagt tcaagggcag ggccaccttg actgtaaacc agtcctccag cacagcctac     240

atggagatcc gcagcctgac atcggaagat tctgcagtct attactgtac aagagggggt     300

gatcaccggt ttgcttactg gggccaaggg actctggtca ctgtctctgc a              351


<210> 279
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2509E5-Ab2 2509E5E5 VL

<400> 279
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      60

atctcctgca gagccagcga aagtgttgat tattatggct ttagttttgt gaactggttc     120

caacagaaac caggacagcc acccaaactc ctcatctata gtgcgtccta caaaggatcc     180

ggggtccctg tcaggttcag tggcagtggg tctgggacag acttcagtct cagcatccat     240

cctatggagg cggatgatac tgcaatgtat ttctgtcagc aaaataagga ggttccgctc     300

acgttcggtg ctgggaccaa gctggagctg aaa                                  333


<210> 280
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VH

<400> 280
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Phe 
            20                  25                  30          
Trp Met Asn Trp Met Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Tyr Pro Gly Asp Gly Asp Ala His Tyr Asn Gly Glu Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Lys Gly Asp Phe Tyr Gly Ser Asn Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 

<210> 281
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VH CDR1

<400> 281
Ser Phe Trp Met 
1               

<210> 282
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VH CDR2

<400> 282
Arg Ile Tyr Pro Gly Asp Gly Asp Ala His Tyr Asn Gly Glu Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 283
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VH CDR3

<400> 283
Lys Gly Asp Phe Tyr Gly Ser Asn Tyr Asp Tyr 
1               5                   10      

<210> 284
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VL

<400> 284
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
His Leu Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 

<210> 285
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VL CDR1

<400> 285
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  

<210> 286
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VL CDR2

<400> 286
Gly Thr Asn Asn Arg Ala Pro 
1               5           

<210> 287
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VL CDR3

<400> 287
Ala Leu Trp Tyr Ser Asn His Leu Val 
1               5                   

<210> 288
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VH

<400> 288
caggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt      60

tcctgcaagg cttctggcta cgcattcagt agtttctgga tgaactggat gaaacagagg     120

cctggaaagg gtcttgagtg gattggacgg atttatcctg gagatggaga tgctcactac     180

aatggggagt tcaagggcag ggccacactg actgcagaca aatcctccag cacagcctac     240

atgcaactca gcagcctgac atctgaggac tctgcggtct acttctgtgc aagaaagggg     300

gatttctacg gtagtaacta cgactattgg ggccaaggca ccactctcac agtctcctca     360


<210> 289
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501B11-Ab3 2501B11C7 VL

<400> 289
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc      60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa     120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt     180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca     240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca tttggtgttc     300

ggtggaggaa ccagactgac tgtccta                                         327


<210> 290
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VH

<400> 290
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Thr Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Glu Asn Ser Asn Phe Ala Lys Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Tyr Asn Gly Ser Ser Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 

<210> 291
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VH CDR1

<400> 291
Thr Tyr Ala Met His 
1               5   

<210> 292
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VH CDR2

<400> 292
Arg Ile Arg Ser Glu Asn Ser Asn Phe Ala Lys Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 293
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VH CDR3

<400> 293
Gly Tyr Asn Gly Ser Ser Leu Asp Tyr 
1               5                   

<210> 294
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VL

<400> 294
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Gly 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 295
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VL CDR1

<400> 295
Ser Ala Ser Ser Ser Val Asn Tyr Met His 
1               5                   10  

<210> 296
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VL CDR2

<400> 296
Asp Thr Ser Lys Leu Ala Ser 
1               5           

<210> 297
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VL CDR3

<400> 297
Gln Gln Trp Arg Ser Asn Pro Pro Thr 
1               5                   

<210> 298
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VH

<400> 298
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaagtc      60

tcatgtgccg cctctggttt caccttcaag acctatgcca tgcactgggt ccgccaggct     120

ccgggaaagg gtttggaatg ggttgctcgc ataagaagtg aaaacagtaa ttttgcaaaa     180

tattatgccg attcagtgaa ggacagattc accatctcca gagatgattc acaaagtatg     240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ttgtgtaagg     300

ggatataacg gcagtagcct tgactactgg ggccaaggca ccactctcac agtctcctca     360


<210> 299
<211> 318
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-2501D10-Ab1 2501D10C3 VL

<400> 299
caaattgttc tcacccagtc tccagcaatc atgtctgcat ttccagggga gagggtcacc      60

atgacctgca gtgccagctc aagtgtaaat tacatgcact ggtaccagca gaagtccggc     120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc     180

ttcagtggcg gtgggtctgg gacctcttac tctctcacaa tcagcaacat ggaggctgaa     240

gatgctgcca cttattactg ccagcagtgg agaagtaatc cacccacttt cggagggggg     300

accaagctgg aaataaaa                                                   318


<210> 300
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4119E10-Ab2 VH

<400> 300
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          
Glu Met Asn Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Phe Leu Leu Ile Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Leu Thr Val Ser Ser 
        115         

<210> 301
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4119E10-Ab2 VH CDR1

<400> 301
Asp Tyr Glu Met Asn 
1               5   

<210> 302
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4119E10-Ab2 VH CDR2

<400> 302
Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 303
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4119E10-Ab2 VH CDR3

<400> 303
Phe Leu Leu Ile Asp Phe Asp Tyr 
1               5               

<210> 304
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4119E10-Ab2 VL

<400> 304
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Lys Lys Ala Gly Gln Ser 
        35                  40                  45              
Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile Lys 
            100                 105                 110         



<210> 305
<400> 305
000

<210> 306
<400> 306
000

<210> 307
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4119E10-Ab2 VL CDR3

<400> 307
Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   

<210> 308
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7087-4119E10-Ab2 VH

<400> 308
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgacgctg      60

tcctgcaagg cttcgggcta cacattttct gactatgaaa tgaactgggt gaagcagaca     120

cctgtgcatg gcctggaatg gattggagct attgatcctg aaactggtgg tactgcctac     180

aatcagaagt tcaagggcaa ggccatactg acttcagaca aatcctccag cacagcctac     240

atggagctcc gcagcctgac atctgaggac tctgccgtct attactgtac aagattcctg     300

ttaatcgact ttgactattg gggccaaggc accactctca cagtctcctc a              351


<210> 309
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7087-4119E10-Ab2 VL

<400> 309
gatgtcttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg     120

tacctgaaga aagcaggcca gtctccaaag gtcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaaaatc     240

agcagggtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg     300

tacacattcg gaggggggac cgagctggaa ataaaa                               336


<210> 310
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4125E6-Ab1 VH

<400> 310
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Gly Leu His Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 311
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4125E6-Ab1 VH CDR1

<400> 311
Ser Tyr Trp Met His 
1               5   

<210> 312
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4125E6-Ab1 VH CDR2

<400> 312
Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210> 313
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4125E6-Ab1 VH CDR3

<400> 313
Gly Leu His Tyr 
1               

<210> 314
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4125E6-Ab1 VL

<400> 314
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          
Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              
Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Phe Ala Ser Ser Pro Leu 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 315
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7087-4125E6-Ab1 VL CDR1

<400> 315
Arg Ala Ser Gln Asp Ile Gly Asn Tyr Leu Asn 
1               5                   10      

<210> 316
<400> 316
000

<210> 317
<400> 317
000

<210> 318
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7087-4125E6-Ab1 VH

<400> 318
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaggctg      60

tcctgcaagg cttctggcta cgccttcacc agctactgga tgcactgggt gaagcagagg     120

cctggacaag gccttgagtg gattggaaat attaatccta gcaatggtgg tactaactac     180

aatgagaagt tcaagaacaa ggccacactg actgtagaca aatcctccag cacagcctat     240

atgcagctca gcggcctgac atctgaggac tctgcggtct attattgtgc aacgggcctt     300

cactactggg gccaaggcac cactctcaca gtctcctca                            339


<210> 319
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7087-4125E6-Ab1 VL

<400> 319
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcact      60

ctcacttgtc gggcaagtca ggacattggt aattacttaa actggcttca gcaggaacca     120

gatggaacta ttaaacgcct gatctacgcc acatccagtt tagattctgg tgtccccaaa     180

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct     240

gaagattttg tagactatta ctgtctacaa tttgctagtt ctccgctcac gttcggtcct     300

gggaccaaac tggaactgaa a                                               321


<210> 320
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VH

<400> 320
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Ser Asp Asn Thr Lys His Asn Asp Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Asp Tyr Asp Val Gly Phe Gly Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 321
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VH CDR1

<400> 321
Ser Tyr Tyr Ile His 
1               5   

<210> 322
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VH CDR2

<400> 322
Trp Ile Tyr Pro Gly Ser Asp Asn Thr Lys His Asn Asp Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 323
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VH CDR3

<400> 323
Asp Tyr Asp Val Gly Phe Gly Tyr 
1               5               

<210> 324
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VL

<400> 324
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ile Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  
Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Gln 
                85                  90                  95      
Glu Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     

<210> 325
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VL CDR1

<400> 325
Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  

<210> 326
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VL CDR2

<400> 326
Ala Ala Ser Asn Gln Gly Ser 
1               5           

<210> 327
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VL CDR3

<400> 327
Gln Gln Ser Gln Glu Val Pro Leu Thr 
1               5                   

<210> 328
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VH

<400> 328
caggtccagc tgcagcagtc tggacctgag ctggtgaggc ctggggcttc agtgaagata      60

tcctgcaagg cttctggcta caggttcaca agctactata tacactgggt gaagcagagg     120

cctggacagg gacttgagtg gattggatgg atttatcctg gaagtgataa tactaagcac     180

aatgacaagt tcaagggcaa ggccacactg acggcagaca catcctccag cactgcctac     240

atgcagctca gcagcctaac atctgaggac tctgcggtct atttctgtgc aagagactac     300

gacgtggggt ttggttactg gggccaaggg actctggtca ctgtctctgc a              351


<210> 329
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301D5-Ab2 VL

<400> 329
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc     120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc     180

ggggtccctg ccaggtttag tggcattggg tctgggacag acttcagcct caacatccat     240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtcagga ggttccgctc     300

acgttcggtg ctgggaccaa gctggagctg aaa                                  333


<210> 330
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301E12-Ab2 VH

<400> 330
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Asp Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Leu Phe 
65                  70                  75                  80  
Met Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Ser Arg Leu Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ala 
    

<210> 331
<400> 331
000

<210> 332
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301E12-Ab2 VH CDR2

<400> 332
Tyr Ile Ser Asp Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      



<210> 333
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301E12-Ab2 VH CDR3

<400> 333
Gly Asp Ser Arg 
1               

<210> 334
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301E12-Ab2 VL

<400> 334
Asp Val Val Leu Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Ile 
            100                 105                 110         



<210> 335
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301E12-Ab2 VL CDR1

<400> 335
Arg Ser Ser Gln Asn Leu Leu Asp Ser Asp Gly Glu Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 336
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301E12-Ab2 VL CDR2

<400> 336
Leu Val Ser Glu Leu Asp Ser 
1               5           

<210> 337
<400> 337
000

<210> 338
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301E12-Ab2 VH

<400> 338
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag     120

tttccaggaa acaaactgga atggatgggc tacataagcg acgatggtag taaaaattac     180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagcttttc     240

atgaagttga attctgtgac tactgaggac acagccacat attactgtgc aagaggcgat     300

tcccgcctgg gccaagggac tctggtcact gtctctgca                            339


<210> 339
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301E12-Ab2 VL

<400> 339
gatgttgtgt tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca ggtcaagtca gaacctctta gatagtgatg gagagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc tgagctggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cagacgttcg gtggaggcac caagctggaa atcatt                               336


<210> 340
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VH

<400> 340
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30          
Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 341
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VH CDR1

<400> 341
Asp Tyr Phe Met Asn 
1               5   

<210> 342
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VH CDR2

<400> 342
Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 343
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VH CDR3

<400> 343
Gly Arg Asn Tyr Ala Met Asp Tyr 
1               5               

<210> 344
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VL

<400> 344
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asp Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 345
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VL CDR1

<400> 345
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 346
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VL CDR2

<400> 346
Ser Ala Ser Thr Arg Glu Ser 
1               5           

<210> 347
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VL CDR3

<400> 347
Lys Gln Ser Tyr Asp Leu Trp Thr 
1               5               

<210> 348
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VH

<400> 348
gaggtccagc tgcaacaatc tggacctgaa ctggtgaagc ctggggcttc agtgaagata      60

tcttgtaagg cttctggata cacgttcgct gactacttca tgaactgggt gaagcagagc     120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactacctac     180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccaa cacagcctac     240

atggagctcc gcagcctgac atctgaggac tctgcagtct actactgtgc aagaggtaga     300

aactacgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a              351


<210> 349
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4301H3-Ab2 VL

<400> 349
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact      60

atgagctgca aatccagtca gagtctcctc aacagtagaa cccgaaagaa ttatttggct     120

tggtaccagc agaaaccagg gcagtctcct aaattgttga tctactcggc atccactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatttg ggacagattt cactctcacc     240

atcagcagtg tgcaggctga ggacctggca gtttattact gcaagcaatc ttatgatctg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 350
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VH

<400> 350
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Asn Gly Asp Ser Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Lys Thr Trp Gly Thr Ala Gln Ala Leu Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala 
        115                 

<210> 351
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VH CDR1

<400> 351
Asp Asp Tyr Met His 
1               5   

<210> 352
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VH CDR2

<400> 352
Trp Ile Asp Pro Glu Asn Gly Asp Ser Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 353
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VH CDR3

<400> 353
Trp Gly Thr Ala Gln Ala Leu Phe Pro Tyr 
1               5                   10  

<210> 354
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VL

<400> 354
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ser 
            20                  25                  30          
Val Gly Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
His Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Met Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 355
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VL CDR1

<400> 355
Lys Ala Ser Gln Asn Val Gly Thr Ser Val Gly 
1               5                   10      

<210> 356
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VL CDR2

<400> 356
Ser Ala Ser Asn Arg Tyr Thr 
1               5           

<210> 357
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VL CDR3

<400> 357
Gln Gln Tyr Arg Ser Tyr Pro Leu Thr 
1               5                   

<210> 358
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VH

<400> 358
gaggttcagc tgcagcagtc tggggctgaa cttgtgaggc caggggcctc agtcaagttg      60

tcctgcacag cttctggctt taacattaaa gacgactata tgcactgggt gaaacagagg     120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga ttctgaatat     180

gcctcgaagt tccagggcaa ggccactatg acagcagaca catcctccaa cacagcctac     240

ctgcaactca gcagcctgac atctgaggac actgccgtct attattgtaa aacatggggg     300

acagctcagg ccctctttcc ttactggggc caagggactc tggtcactgt ctctgca        357


<210> 359
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A1-Ab1 VL

<400> 359
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc      60

atcacctgca aggccagtca gaatgtgggt acttctgtag gctggtatca acaaaaagca     120

ggacaatctc ctaaactact gattcactcg gcatctaatc ggtacactgg agtccctgat     180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcaacaa tatgcagtct     240

gaagacctgg cagattattt ctgccagcaa tatagaagtt atccgctcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 360
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VH

<400> 360
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Asp Pro Glu Thr Gly Gly Ala Val Gln Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Asn Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Asn Cys 
                85                  90                  95      
Ala Met Gly Ala Ala Leu Arg Leu Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 361
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VH CDR1

<400> 361
Asp Tyr Glu Met His 
1               5   

<210> 362
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VH CDR2

<400> 362
Val Ile Asp Pro Glu Thr Gly Gly Ala Val Gln Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 363
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VH CDR3

<400> 363
Gly Ala Ala Leu Arg Leu Ala Tyr 
1               5               

<210> 364
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VL

<400> 364
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Ser Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 365
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VL CDR1

<400> 365
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Ser Tyr Leu Glu 
1               5                   10                  15      



<210> 366
<400> 366
000

<210> 367
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VL CDR3

<400> 367
Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   

<210> 368
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VH

<400> 368
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgacgctg      60

tcctgcaagg cttcgggcta cacatttact gactatgaaa tgcactgggt gaaacagaca     120

cctgtgcatg gcctggagtg gattggagtt attgatcctg aaactggtgg tgctgtccag     180

aatcagaagt tcaagggcaa ggccatactg actgcagaca attcctccag cacagcctac     240

atggacctcc gcagcctgac atctgaggac tctgccgtct ataactgtgc aatgggtgcg     300

gcattacggc ttgcttactg gggccaaggg actctggtca ctgtctctgc a              351


<210> 369
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303A3-Ab1 VL

<400> 369
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcattgta catagtaatg gaaactccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

aacagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcca     300

ttcacgttcg gctcggggac aaagttggaa ataaaa                               336


<210> 370
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303B6-Ab2 VH

<400> 370
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Gly Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Tyr Ser Gly Ser Arg Leu Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Ser Gln Gly Ser Ser Val Thr Val Ser Ser 
        115                 120             

<210> 371
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303B6-Ab2 VH CDR1

<400> 371
Asp Tyr Tyr Met Asn 
1               5   

<210> 372
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303B6-Ab2 VH CDR2

<400> 372
Asp Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210> 373
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303B6-Ab2 VH CDR3

<400> 373
Ser Gly Tyr Ser Gly Ser Arg Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  

<210> 374
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303B6-Ab2 VL

<400> 374
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Arg 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asp Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 375
<400> 375
000

<210> 376
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303B6-Ab2 VL CDR2

<400> 376
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 377
<400> 377
000

<210> 378
<211> 369
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303B6-Ab2 VH

<400> 378
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagata      60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc     120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactacctac     180

aaccagaagt tcaaggacaa ggccacattg actgtggaca ggtcctccag cacagcctac     240

atggaactcc gcagcctgac atctggggac tctgcagtct attactgtgc aagatcgggg     300

tactccggta gtcgcctcta ctatgctatg gactactgga gtcaaggatc ctcagtcacc     360

gtctcctca                                                             369


<210> 379
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303B6-Ab2 VL

<400> 379
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcacgaga gaaggtcact      60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct     120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tcttctgggc ttccactagg     180

gaatctgggg tccctgatcg cttcactggc agtggatctg ggacagattt cactctcacc     240

atcagcagtg tgcaggctga agacctggca gtttattact gcaaacaatc ttatgatctg     300

tggacgttcg gtggcggcac caagctggaa atcaaa                               336


<210> 380
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VH

<400> 380
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Gln Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Arg Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Ala Gly Ser Gly Val Gln Leu Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ala 
        115                 

<210> 381
<400> 381
000

<210> 382
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VH CDR2

<400> 382
Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 383
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VH CDR3

<400> 383
Ala Gly Ser Gly Val Gln Leu Phe Asp Tyr 
1               5                   10  

<210> 384
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VL

<400> 384
Asp Ile Leu Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              
Ser Ser Ala Ser Ser Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 385
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VL CDR1

<400> 385
Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      

<210> 386
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VL CDR2

<400> 386
Ser Ala Ser Ser Arg Tyr Ser 
1               5           

<210> 387
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VL CDR3

<400> 387
Gln Gln Tyr Asn Arg Tyr Pro Leu Thr 
1               5                   

<210> 388
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VH

<400> 388
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctc agtcaagttg      60

tcctgcacag cttctggctt taacattcaa gacgactata tgcactgggt gaagcagagg     120

cctgaacagg gcctggagtg gattggttgg attgatcctg agaatggtga tactgaatat     180

gcctcgaaat tccagggcaa ggccacttta acagcagaca catcctccaa cacagcctac     240

ctgcagctca gcagactgac atctgaggac actgccgtct attactgtac tacagcgggc     300

tcaggcgtcc aactctttga ctactggggc caaggcacca ctctcacagt ctcctca        357


<210> 389
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4303H6-Ab1 VL

<400> 389
gacattttga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc      60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca     120

gggcaatctc ctaaaccact gatttcctcg gcatcctccc ggtacagtgg cgtccctgat     180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct     240

gaagacttgg cagactattt ctgtcagcaa tataaccgct atcctctcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 390
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4305H7-Ab1 VH

<400> 390
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Met Ile Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Lys Thr Trp Gly Thr Thr Gln Ala Leu Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 391
<400> 391
000

<210> 392
<400> 392
000

<210> 393
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4305H7-Ab1 VH CDR3

<400> 393
Trp Gly Thr Thr Gln Ala Leu Phe Pro Tyr 
1               5                   10  

<210> 394
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4305H7-Ab1 VL

<400> 394
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          
Val Gly Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
His Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Met Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 395
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4305H7-Ab1 VL CDR1

<400> 395
Lys Ala Ser Gln Asn Val Gly Thr Ala Val Gly 
1               5                   10      

<210> 396
<400> 396
000

<210> 397
<400> 397
000

<210> 398
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4305H7-Ab1 VH

<400> 398
gaggttcagc tgcagcagtc tggggctgaa cttgtgaggc caggggcctc agtcaagttg      60

tcctgcacag cttctggctt taacattaaa gacgactata tgcactgggt gaagcagagg     120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat     180

gcctcgaagt tccagggcaa ggccactatg atagcagaca catcctccaa cacagcctac     240

ctgcaactca gcagcctgac atctgaggac actgccgtct attattgtaa aacatggggg     300

acaactcagg ccctctttcc ttactggggc caagggactc tggtcactgt ctctgca        357


<210> 399
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4305H7-Ab1 VL

<400> 399
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc      60

atcacctgca aggccagtca gaatgtgggt actgctgtag gctggtatca acaaaaagca     120

ggacaatctc ctaaactact gattcactcg gcatccaatc ggtacactgg agtccctgat     180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcaacaa tatgcagtct     240

gaagacctgg cagattattt ctgccagcaa tatagaagtt atccgctcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 400
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4317A4-Ab1 VH

<400> 400
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Lys Thr Trp Gly Thr Thr Gln Ala Leu Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala 
        115                 

<210> 401
<400> 401
000

<210> 402
<400> 402
000

<210> 403
<400> 403
000

<210> 404
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4317A4-Ab1 VL

<400> 404
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Tyr Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Ala 
            20                  25                  30          
Val Gly Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
His Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Met Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 405
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7088-4317A4-Ab1 VL CDR1

<400> 405
Lys Ala Ser Gln Asn Val Gly Asn Ala Val Gly 
1               5                   10      

<210> 406
<400> 406
000

<210> 407
<400> 407
000

<210> 408
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4317A4-Ab1 VH

<400> 408
gaggttcagc tgcagcagtc tggggctgaa cttgtgaggc caggggcctc agtcaagttg      60

tcctgcacag cttctggctt taacattaaa gacgactata tgcactgggt gaagcagagg     120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat     180

gcctcgaagt tccagggcaa ggccactatg acagcagaca catcctccaa cacagcctac     240

ctgcaactca gcagcctgac atctgaggac actgccgtct attattgtaa aacatggggg     300

acaactcagg ccctctttcc ttactggggc caagggactc tggtcactgt ctctgca        357


<210> 409
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7088-4317A4-Ab1 VL

<400> 409
gacattgtga tgacccagtc tcaaaagttc atgtacacat cagtgggaga cagggtcagc      60

atcacctgca aggccagtca gaatgtgggt aatgctgtag gctggtatca acaaaaagca     120

ggacaatctc ctaaactact gattcactcg gcatccaatc ggtacactgg agtccctgat     180

cgcttcacag gcactggatc tgggacagat ttcactctca ccatcaacaa tatgcagtct     240

gaagacctgg cagattattt ctgccagcaa tatagaagtt atccgctcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 410
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4409F1-Ab1 VH

<400> 410
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Arg Gly 
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Arg Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Lys Leu Lys Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Asp Ser Asn Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         
Ala 
    

<210> 411
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4409F1-Ab1 VH CDR1

<400> 411
Arg Gly Tyr Tyr Trp Asn 
1               5       

<210> 412
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4409F1-Ab1 VH CDR2

<400> 412
Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Arg Asn 
1               5                   10                  15      



<210> 413
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4409F1-Ab1 VH CDR3

<400> 413
Gly Asp Ser Asn 
1               

<210> 414
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4409F1-Ab1 VL

<400> 414
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 415
<400> 415
000

<210> 416
<400> 416
000

<210> 417
<400> 417
000

<210> 418
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4409F1-Ab1 VH

<400> 418
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggcta ctccatcacc aggggttatt actggaactg gatccggcag     120

tttccaggaa acaaactgga atggatgggc tacataagct acgatggtag caataactac     180

aacccatctc tcagaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc     240

ctgaagttga aatctgtgac tactgaggac acagccacat atttctgtgc aagaggggat     300

agtaactggg gccaaggcac cactctcaca gtctcctca                            339


<210> 419
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4409F1-Ab1 VL

<400> 419
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gagagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggtagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cagacgttcg gtggaggcac caagttggaa atcaaa                               336


<210> 420
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VH

<400> 420
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          
Gly Ile Ser Trp Leu Lys His Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Gly Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ala 
            100                 105                 110         



<210> 421
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VH CDR1

<400> 421
Ser Ser Gly Ile Ser 
1               5   

<210> 422
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VH CDR2

<400> 422
Asp Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210> 423
<400> 423
000

<210> 424
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VL

<400> 424
Asp Ile Val Ile Thr Gln Asp Asp Leu Ser Asn Pro Val Thr Ser Gly 
1               5                   10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile 
65                  70                  75                  80  
Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu 
                85                  90                  95      
Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         



<210> 425
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VL CDR1

<400> 425
Arg Ser Ser Lys Ser Leu Leu Tyr Lys Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 426
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VL CDR2

<400> 426
Leu Met Ser Thr Arg Ala Ser 
1               5           

<210> 427
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VL CDR3

<400> 427
Gln Gln Leu Leu Glu Tyr Pro Leu Thr 
1               5                   

<210> 428
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VH

<400> 428
caggttcagc tgcagcagtc tggagctgag ctggcgaggc ctggggcttc agtgaaggtg      60

tcctgcaagg cttctggcta caccttcaca agctctggta taagctggtt gaagcacaga     120

actggacagg gccttgagtg gattggagac atttatccta gaagtggtaa tacttactac     180

aatgagaaat tcaaggacaa ggccacactg actgcagaca aatcctccag cacggcgtac     240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagtggtaac     300

tactggggcc aaggcaccac tctcacagtc tcctca                               336


<210> 429
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4415G5-Ab1 VL

<400> 429
gatattgtga taacccagga tgacctctcc aatcctgtca cttctggaga atcagtttcc      60

atctcctgca ggtctagtaa gagtctccta tataaggatg ggaagacata cttgaattgg     120

tttctgcaga gaccaggaca atctcctcag ctcctgatct atttgatgtc cacccgtgca     180

tcaggagtct cagaccggtt tagtggcagt gggtcaggaa cagatttcac cctggaaatc     240

agtagagtga aggctgagga tgtgggtgtg tattactgtc aacaactttt agagtatccg     300

ctcacgttcg gtgctgggac caagctggag ctgaaa                               336


<210> 430
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VH

<400> 430
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          
Glu Met His Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly Ala 
        35                  40                  45              
Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Ile Gln Lys Phe Lys Gly 
    50                  55                  60                  
Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  
Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
                85                  90                  95      
Gly Trp Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ala 
        

<210> 431
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VH CDR1

<400> 431
Gly Tyr Glu Met His 
1               5   

<210> 432
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VH CDR2

<400> 432
Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Ile Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 433
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VH CDR3

<400> 433
Gly Trp Asp Tyr Phe Asp Tyr 
1               5           

<210> 434
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VL

<400> 434
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Phe Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 435
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VL CDR1

<400> 435
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Phe Thr Tyr Leu His 
1               5                   10                  15      



<210> 436
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VL CDR2

<400> 436
Arg Val Ser Asn Arg Phe Ser 
1               5           

<210> 437
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VL CDR3

<400> 437
Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   

<210> 438
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VH

<400> 438
caggttcaac tgcagcagtc tggggctgag ttggtgaggc ctggggcttc agtgacgctg      60

tcctgcaagg cttcgggcta cacatttact ggctatgaaa tgcactgggt gaagcagaca     120

cctgtgcatg gcctggaatg gattggagct attgatcctg aaaccggtgg aactgcctat     180

attcagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac     240

atggagctcc gcagcctgac atctgaggac tctgccgtct attactgtac aagaggctgg     300

gactattttg actactgggg ccaaggcacc actctcacag tctcctca                  348


<210> 439
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4417G6-Ab1 VL

<400> 439
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagccttcta cacagtaatg gattcaccta tttacattgg     120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acagagtttc caatcgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg     300

tacacgttcg gaggggggac caagctggaa ataaaa                               336


<210> 440
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4418C5-Ab1 VH

<400> 440
Asp Gly Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Asn Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Lys Phe Asn Phe Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Asp Val Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 441
<400> 441
000

<210> 442
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4418C5-Ab1 VH CDR2

<400> 442
Tyr Ile Asn Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      



<210> 443
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4418C5-Ab1 VH CDR3

<400> 443
Gly Asp Val Tyr 
1               

<210> 444
<400> 444
000

<210> 445
<400> 445
000

<210> 446
<400> 446
000

<210> 447
<400> 447
000

<210> 448
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4418C5-Ab1 VH

<400> 448
gatggacaac ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggcta ctccatcacc agtggatatt actggaactg gatccggcag     120

tttccaggaa acaaactgga atggatgggc tacataaact acgatggtag caataactac     180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa tcagtttttc     240

ctgaagttca attttgtgac tactgaggac acagccacat attactgtgt gaggggggac     300

gtctactggg gccaaggcac cactctcaca gtctcctca                            339


<210> 449
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4418C5-Ab1 VL

<400> 449
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gagagacata tttgaattgg     120

ttattacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cagacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 450
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7089-4418F6-Ab1 VH

<400> 450
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          
Gly Ile Ser Trp Leu Lys His Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ser Ser Gly Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         



<210> 451
<400> 451
000

<210> 452
<400> 452
000

<210> 453
<400> 453
000

<210> 454
<400> 454
000

<210> 455
<400> 455
000

<210> 456
<400> 456
000

<210> 457
<400> 457
000

<210> 458
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4418F6-Ab1 VH

<400> 458
caggttcagc tgcagcagtc tggagctgag ctggcgaggc ctggggcttc agtgaaggtg      60

tcctgcaagg cttctggcta caccttcaca agttctggta taagctggtt gaagcacaga     120

actggacagg gccttgagtg gattggagac atttatccta gaagtggtaa tacttactac     180

aatgagaaat tcaaggacaa ggccacactg actgcagaca aatcctccag cacggcgtac     240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgttc aagtggtaac     300

tactggggcc aaggcaccac tctcacagtc tcctca                               336


<210> 459
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7089-4418F6-Ab1 VL

<400> 459
gatattgtga taacccagga tgacctctcc aatcctgtca cttctggaga atcagtttcc      60

atctcctgta ggtctagtaa gagtctccta tataaggatg ggaagacata cttgaattgg     120

tttctgcaga gaccaggaca atctcctcag ctcctgatct atttgatgtc cacccgtgca     180

tcaggagtct cagaccggtt tagtggcagt gggtcaggaa cagatttcac cctggaaatc     240

agtagagtga aggctgagga tgtgggtgtg tattactgtc aacaactttt agagtatccg     300

ctcacgttcg gtgctgggac caagctggag ctgaaa                               336


<210> 460
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VH

<400> 460
Gln Val His Leu Lys Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Ser Ala Glu Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Val Val Gly Tyr Tyr Gly Ala Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 461
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VH CDR1

<400> 461
Asp Tyr Tyr Ile Asn 
1               5   

<210> 462
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VH CDR2

<400> 462
Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 463
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VH CDR3

<400> 463
Gly Tyr Tyr Gly Ala 
1               5   

<210> 464
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VL

<400> 464
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Lys Thr His Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 465
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VL CDR1

<400> 465
Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Lys Thr His Leu His 
1               5                   10                  15      



<210> 466
<400> 466
000

<210> 467
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VL CDR3

<400> 467
Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   

<210> 468
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VH

<400> 468
caggtccacc tgaagcagtc tggggctgac ctggtgaggc ctggggcttc agtgaagctg      60

tcctgcaagg cgtctggcta cactttcact gactactata taaactgggt gaagcagagg     120

cctggacagg gacttgagtg gattgcaagg atttatcctg gaagtggtaa tacttactac     180

aatgagaagt tcaagggcag ggccacactg agtgcagaaa aatcctccac cactgcctac     240

atgcagctca gcagcctgac atctgaggac tctgctgtct atttctgtgt agtggggtac     300

tacggtgcct ggggccaagg caccactctc acagtctcct ca                        342


<210> 469
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-5A12-Ab1 VL

<400> 469
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgta gatctagtca gagccttgta cacagtaatg gaaaaaccca tttacattgg     120

tacctgcaga agccaggcca gtctccaaag ctcctgatct ataaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 470
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VH

<400> 470
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Ser Asn Asn Phe Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Glu Ser Glu Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 471
<400> 471
000

<210> 472
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VH CDR2

<400> 472
Arg Ile Arg Ser Lys Ser Asn Asn Phe Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 473
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VH CDR3

<400> 473
Ser Phe Asp Tyr 
1               

<210> 474
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VL

<400> 474
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              
Tyr Arg Ala Lys Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe 
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 475
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VL CDR1

<400> 475
Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      

<210> 476
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VL CDR2

<400> 476
Arg Ala Lys Arg Leu Val Asp 
1               5           

<210> 477
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VL CDR3

<400> 477
Leu Gln Tyr Asp Glu Phe Pro Phe Thr 
1               5                   

<210> 478
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VH

<400> 478
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc      60

tcatgtgcag cctctggatt cagcttcaat acctacgcca tgaactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttttgcaaca     180

tattatgccg attcagtgaa agacagattc accatctcca gagatgaatc agaaagcatg     240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgagg     300

tcctttgact actggggcca aggcaccact ctcacagtct cctca                     345


<210> 479
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-25A3-Ab1 VL

<400> 479
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact      60

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca     120

gggaaatctc ctaagaccct aatctatcgt gcaaaaagat tggtagatgg ggtcccatca     180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat     240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttccattcac gttcggctcg     300

gggacaaagt tggaaataaa a                                               321


<210> 480
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1G10-Ab1 VH

<400> 480
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Val Phe Leu Thr Cys Thr Val Thr Gly Ile Ser Ile Thr Thr Gly 
            20                  25                  30          
Asn Tyr Arg Trp Ser Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Ile Thr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Thr Ser Arg Thr Thr Ile Thr Arg Asp Thr Pro Lys Asn Gln Phe 
65                  70                  75                  80  
Phe Leu Glu Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser 
        115                 

<210> 481
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1G10-Ab1 VH CDR1

<400> 481
Thr Gly Asn Tyr Arg Trp Ser 
1               5           

<210> 482
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1G10-Ab1 VH CDR2

<400> 482
Tyr Ile Tyr Tyr Ser Gly Thr Ile Thr Tyr Asn Pro Ser Leu Thr Ser 
1               5                   10                  15      



<210> 483
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1G10-Ab1 VH CDR3

<400> 483
Ile Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   

<210> 484
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1G10-Ab1 VL

<400> 484
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 485
<400> 485
000

<210> 486
<400> 486
000

<210> 487
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1G10-Ab1 VL CDR3

<400> 487
Ser Gln Ser Thr His Val Pro His Thr 
1               5                   

<210> 488
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-1G10-Ab1 VH

<400> 488
gatgtgcagc ttcaggagtc aggacctggc ctggtgaaac cttctcagac agtgttcctc      60

acctgcactg tcactggcat ttccatcacc actggaaatt acaggtggag ctggatccgg     120

cagtttccag gaaacaaact ggagtggata gggtacatat actacagtgg taccattacc     180

tacaatccat ctctcacaag tcgaaccacc atcactagag acactcccaa gaaccagttc     240

ttcctggaaa tgaactcttt gactgctgag gacacagcca catactactg tgcacggatt     300

tactacggta atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctca        357


<210> 489
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-1G10-Ab1 VL

<400> 489
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg     120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct     300

cacacgttcg gaggggggac caagctggaa ataaaa                               336


<210> 490
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VH

<400> 490
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      
Tyr Cys Val Ser Glu Ser Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ala 
        115 

<210> 491
<400> 491
000

<210> 492
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VH CDR2

<400> 492
Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Val Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 493
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VH CDR3

<400> 493
Glu Ser Ala Tyr 
1               

<210> 494
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VL

<400> 494
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 495
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VL CDR1

<400> 495
Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      



<210> 496
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VL CDR2

<400> 496
Lys Val Ser Asn Arg Leu Ser 
1               5           

<210> 497
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VL CDR3

<400> 497
Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   

<210> 498
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VH

<400> 498
gaggtgcaac ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc      60

tcatgtgcag cctctggatt cagcttcaat acctacgcca tgaactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttatgcaaca     180

tattatgtcg attcagtgaa agacagattc accatctcca gagatgattc agaaagcatg     240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccctgtatta ctgtgtgagc     300

gaatccgctt actggggcca agggactctg gtcactgtct ctgca                     345


<210> 499
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-19A2-Ab1 VL

<400> 499
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttatattgg     120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgactt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcca     300

ttcacgttcg gctcggggac aaagttggaa ataaaa                               336


<210> 500
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-8C10-Ab1 VH

<400> 500
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Gln Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Asn Asp Gly Ser Ser Lys Thr Asn Pro Ser Leu 
    50                  55                  60                  
Thr Asn Arg Ile Ser Val Thr Arg Asp Thr Ser Lys Asn Gln Val Phe 
65                  70                  75                  80  
Leu Lys Leu Lys Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Asp Gln His Trp Gly Gln Gly Thr Ala Leu Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 501
<400> 501
000

<210> 502
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-8C10-Ab1 VH CDR2

<400> 502
Tyr Ile Ser Asn Asp Gly Ser Ser Lys Thr Asn Pro Ser Leu Thr Asn 
1               5                   10                  15      



<210> 503
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-8C10-Ab1 VH CDR3

<400> 503
Gly Asp Gln His 
1               

<210> 504
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-8C10-Ab1 VL

<400> 504
Asp Val Val Leu Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Ser 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Leu Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 505
<400> 505
000

<210> 506
<400> 506
000

<210> 507
<400> 507
000

<210> 508
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-8C10-Ab1 VH

<400> 508
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggcca atccatcacc agtggttatt actggaactg gatccggcaa     120

tttccaggaa acaaactgga atggatgggc tacataagca acgatggtag cagtaaaacc     180

aacccatctc tcacaaatcg aatctccgtc actcgtgaca catctaagaa ccaggttttc     240

ctgaagttga aatctgtgac tactgaggac acagccacat attactgtgt aagaggggac     300

cagcactggg gccaaggcac cgctctcaca gtctcctca                            339


<210> 509
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-8C10-Ab1 VL

<400> 509
gatgttgtgt tgacccagac tccactcact ttgtcagtta ccattgggca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gagagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc tgaactggac     180

tctggagtct ctgacaggtt cactggcagt ggttcaggga cagatttcac actgaaaatc     240

agcagactgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cagacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 510
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VH

<400> 510
Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Asn Leu Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Asn Val Asn Pro Asn Asn Ser Asp Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Arg Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Pro Tyr Tyr Gly Gly Arg Tyr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 

<210> 511
<400> 511
000

<210> 512
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VH CDR2

<400> 512
Asn Val Asn Pro Asn Asn Ser Asp Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Arg 
    

<210> 513
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VH CDR3

<400> 513
Ser Pro Tyr Tyr Gly Gly Arg Tyr Leu Asp Tyr 
1               5                   10      

<210> 514
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VL

<400> 514
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Arg 
            20                  25                  30          
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Phe Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210> 515
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VL CDR1

<400> 515
Lys Ser Ser Gln Ser Leu Leu Tyr Arg Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 516
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VL CDR2

<400> 516
Trp Ala Phe Thr Arg Glu Ser 
1               5           

<210> 517
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VL CDR3

<400> 517
Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr 
1               5                   

<210> 518
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VH

<400> 518
caggtccaac tacagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaacctg      60

ccctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg     120

cctggtcaag gccttgattg gattggaaat gttaatccta acaatagtga tagtaattac     180

aatgagaagt tcaagaggaa ggccacactg actgtagaca aatcctccag cacagcctac     240

atgcacctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagatctcct     300

tactacggtg gccgttacct tgactactgg ggccaaggca ccactctcac agtctcctca     360


<210> 519
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-7A2-Ab1 VL

<400> 519
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact      60

atgacctgca agtccagtca gagcctttta tatagaagca atcaaaagaa ctacttggcc     120

tggtaccagc agaaaccagg acagtctcct aaactgttga tttactgggc attcactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc     240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat     300

cctctcacgt tcggtgctgg gaccaagctg gagctgaaa                            339


<210> 520
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1A12-Ab1 VH

<400> 520
Gln Val His Leu Lys Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Phe 
            20                  25                  30          
Tyr Ile Asn Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Arg Ile Tyr Pro Gly Asn Asn Asn Thr Phe Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Ser Ala Glu Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Val Val Gly Tyr Tyr Gly Ala Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 521
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1A12-Ab1 VH CDR1

<400> 521
Asp Phe Tyr Ile Asn 
1               5   

<210> 522
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1A12-Ab1 VH CDR2

<400> 522
Arg Ile Tyr Pro Gly Asn Asn Asn Thr Phe Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 523
<400> 523
000

<210> 524
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1A12-Ab1 VL

<400> 524
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr His Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Phe Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 525
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1A12-Ab1 VL CDR1

<400> 525
Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr His Leu His 
1               5                   10                  15      



<210> 526
<400> 526
000

<210> 527
<400> 527
000

<210> 528
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-1A12-Ab1 VH

<400> 528
caggtccacc tgaagcagtc tggggctgac ctggtgaggc ctggggcttc agtgaagctg      60

tcctgcaagg cgtctggcta cagtttcact gacttttata taaattgggt gaagcagacg     120

cctggacagg gacttgagtg gattgcgagg atttatcctg gaaataataa tactttctac     180

aatgagaaat tcaagggcaa ggccacactg agtgcagaaa aatcctccac cactgcctac     240

atgcagctca gcagcctgac atctgaggac tctgctgtct atttctgtgt agtggggtac     300

tacggtgcct ggggccaagg caccactctc acagtctcct ca                        342


<210> 529
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-1A12-Ab1 VL

<400> 529
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccca tttgcattgg     120

tacctgcaga agccaggcca gtctccaaag ctcctgatct ataaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctaggattt tatttctgct ctcaaagtac acatgttccg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 530
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-4F3-Ab1 VH

<400> 530
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Thr Gly Thr Asn Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Ala Ser Leu Thr Val Asp Lys Phe Ser Ser Ala Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr Gly Tyr Gly Asp Pro Ile Ser Ser Tyr Tyr Tyr Ala Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 

<210> 531
<400> 531
000

<210> 532
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-4F3-Ab1 VH CDR2

<400> 532
Asp Ile Asn Pro Asn Thr Gly Thr Asn Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 533
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-4F3-Ab1 VH CDR3

<400> 533
Thr Gly Tyr Gly Asp Pro Ile Ser Ser Tyr Tyr Tyr Ala Leu Asp Tyr 
1               5                   10                  15      



<210> 534
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-4F3-Ab1 VL

<400> 534
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 535
<400> 535
000

<210> 536
<400> 536
000

<210> 537
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-4F3-Ab1 VL CDR3

<400> 537
Lys Gln Ser Tyr Asn Leu Trp Thr 
1               5               

<210> 538
<211> 375
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-4F3-Ab1 VH

<400> 538
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagata      60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc     120

catggaaaga gccttgaatg gattggagat attaatccta acactggtac taatagctac     180

aaccagaagt tcaagggcag ggcctcactg actgtagaca agttctccag cgcagcctac     240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagaaccggc     300

tatggcgacc ctatttcctc atattactat gctctggact actggggtca aggaacctca     360

gtcaccgtct cctca                                                      375


<210> 539
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-4F3-Ab1 VL

<400> 539
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact      60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct     120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc     240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 540
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-17F5-Ab1 VH

<400> 540
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Ile Asp Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Asp Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr Ser 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 541
<400> 541
000

<210> 542
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-17F5-Ab1 VH CDR2

<400> 542
Asp Ile Asn Pro Asn Ile Asp Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 543
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-17F5-Ab1 VH CDR3

<400> 543
Gly Arg Asp Tyr Ala Met Asp Phe 
1               5               

<210> 544
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-17F5-Ab1 VL

<400> 544
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asp Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 545
<400> 545
000

<210> 546
<400> 546
000

<210> 547
<400> 547
000

<210> 548
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-17F5-Ab1 VH

<400> 548
gaggtccaac tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagata      60

tcctgtaagg cttctggata cacgttcact gactacttca tgaactgggt gaagcagagc     120

catggaaaga gccttgagtg gattggagat attaatccta acattgatgt tactaactac     180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac     240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagagggcgg     300

gactatgcta tggacttctg gggtcaagga acctcagtca ccgtctcctc a              351


<210> 549
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-17F5-Ab1 VL

<400> 549
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact      60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct     120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt caccctcacc     240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttatgatctg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 550
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VH

<400> 550
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Ile Thr Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Asp Ile Tyr Pro Gly Gly Gly Val Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Thr Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Ala Gln Thr Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ala 
        115     

<210> 551
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VH CDR1

<400> 551
Ser Tyr Trp Ile Thr 
1               5   

<210> 552
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VH CDR2

<400> 552
Asp Ile Tyr Pro Gly Gly Gly Val Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Thr 
    

<210> 553
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VH CDR3

<400> 553
Ala Gln Thr Thr Phe Ala Tyr 
1               5           

<210> 554
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VL

<400> 554
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Asn 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 555
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VL CDR1

<400> 555
Arg Ser Ser Gln Asn Ile Val His Asn Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 556
<400> 556
000

<210> 557
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VL CDR3

<400> 557
Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   

<210> 558
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VH

<400> 558
caggtccaac tccagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagatg      60

tcctgcaagg ctgctggcta caccttcagc agctactgga taacctgggt gaggcagagg     120

cctggacaag gccttgactg gattggagat atttatcctg gtggaggtgt tactaactac     180

aatgagaagt tcaagaccaa ggccacactg actgtagaca catcctccag cacagcctac     240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc gacagctcag     300

actacgtttg cttactgggg ccaagggact ctggtcactg tctctgca                  348


<210> 559
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-18C11-Ab1 VL

<400> 559
gatgttttga tgacccaaac tccactgtcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gaacattgta cataataatg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct     300

cggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 560
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18D12-Ab1 VH

<400> 560
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Ile Thr Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Asp Ile Tyr Pro Gly Gly Gly Val Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Thr Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Thr Ala Gln Thr Thr Phe Ala His Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ala 
        115     

<210> 561
<400> 561
000

<210> 562
<400> 562
000

<210> 563
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18D12-Ab1 VH CDR3

<400> 563
Ala Gln Thr Thr Phe Ala His 
1               5           

<210> 564
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18D12-Ab1 VL

<400> 564
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Ala His Asn 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 565
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-18D12-Ab1 VL CDR1

<400> 565
Arg Ser Ser Gln Asn Ile Ala His Asn Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 566
<400> 566
000

<210> 567
<400> 567
000

<210> 568
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-18D12-Ab1 VH

<400> 568
caggtccaac tccagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagatg      60

tcctgcaagg cttctggcta caccttcacc agctactgga taacctgggt gaggcagagg     120

cctggacaag gccttgactg gattggagat atttatcctg gtggaggtgt tactaactac     180

aatgagaagt tcaagaccaa ggccacactg actgtagaca catcctccag cacagcctac     240

atgcacctca gcagcctgac atctgaggac tctgcggtct atttctgtgc gacagctcag     300

actacgtttg ctcactgggg ccaagggact ctggtcactg tctctgca                  348


<210> 569
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-18D12-Ab1 VL

<400> 569
gatgttttga tgacccaaac tccactctcc ctgcccgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gaatattgca cataataatg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct     300

cggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 570
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1F8-Ab1 VH

<400> 570
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          
Phe Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Ile Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Lys Leu Lys Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Asp Val Asp Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 571
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1F8-Ab1 VH CDR1

<400> 571
Ser Gly Phe Tyr Trp Asn 
1               5       

<210> 572
<400> 572
000

<210> 573
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1F8-Ab1 VH CDR3

<400> 573
Gly Asp Val Asp 
1               

<210> 574
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-1F8-Ab1 VL

<400> 574
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Leu Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 575
<400> 575
000

<210> 576
<400> 576
000

<210> 577
<400> 577
000

<210> 578
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-1F8-Ab1 VH

<400> 578
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggcta ctccatcacc agtgggtttt actggaactg gatccggcaa     120

tttccaggaa ataaactgga atggatgggc tacataagct acgatggtag caataactac     180

aacccatctc tcaaaaatcg aatctccatt attcgtgaca catctaagaa ccagtttttc     240

ctgaagttga aatctgtgac ttctgaggac acagccacat attattgtgt aagaggggac     300

gtcgactggg gccaaggcac cactctcact gtctcctca                            339


<210> 579
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-1F8-Ab1 VL

<400> 579
gatgttgtga tgacccagac tccactcact ttgtcggtca ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gagagacata tttgaattgg     120

ttgtttcaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg agcctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cagacgctcg gtggaggcac caagctggaa atcaaa                               336


<210> 580
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VH

<400> 580
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Asn Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gln Leu Arg Arg Asp Gly Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 581
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VH CDR1

<400> 581
Ser Tyr Gly Met Ser 
1               5   

<210> 582
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VH CDR2

<400> 582
Thr Ile Ser Asn Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 583
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VH CDR3

<400> 583
Gln Leu Arg Arg Asp Gly Trp Tyr Phe Asp Val 
1               5                   10      

<210> 584
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VL

<400> 584
Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          
Lys Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Leu Trp 
        35                  40                  45              
Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      
Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             

<210> 585
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VL CDR1

<400> 585
Ser Val Ser Ser Ser Ile Ser Ser Ser Lys Leu His 
1               5                   10          

<210> 586
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VL CDR2

<400> 586
Gly Thr Ser Asn Leu Ala Ser 
1               5           

<210> 587
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VL CDR3

<400> 587
Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   

<210> 588
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VH

<400> 588
gaggtgcaac tagtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc      60

tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact     120

ccagacaaga ggctggagtg ggtcgcaacc attagtaatg gtggtagtta cacctactat     180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac     240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacaatta     300

cgacgggacg gttggtactt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca     360


<210> 589
<211> 324
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-22E5-Ab1 VL

<400> 589
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc      60

atcacctgca gtgtcagctc aagtataagt tccagcaagt tgcactggta ccagcagaag     120

tcagaaacct cccccaaact ctggatttat ggcacatcca acctggcttc tggagtccct     180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag     240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gttacccact cacgttcggt     300

gctgggacca agctggagct gaaa                                            324


<210> 590
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-27D8-Ab1 VH

<400> 590
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Ser Asn Asn Phe Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Glu Ser Glu Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 591
<400> 591
000

<210> 592
<400> 592
000

<210> 593
<400> 593
000

<210> 594
<400> 594
000

<210> 595
<400> 595
000

<210> 596
<400> 596
000

<210> 597
<400> 597
000

<210> 598
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-27D8-Ab1 VH

<400> 598
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc      60

tcatgtgcag cctctggatt caccttcaat acctacgcca tgaactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttttgcaaca     180

tattatgccg attcagtgaa agacagattc accatctcca gagatgaatc agaaagcatg     240

ctctatctgc aaatgaacaa cttgaaagct gaggacacag ccatgtatta ctgtgtgagg     300

tcctttgact actggggcca aggcaccact ctcacagtct cctca                     345


<210> 599
<400> 599
000

<210> 600
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-21C8-Ab1 VH

<400> 600
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Ile Thr Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Asp Ile Tyr Pro Gly Gly Gly Val Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Thr Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Thr Ala Gln Thr Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ala 
        115     

<210> 601
<400> 601
000

<210> 602
<400> 602
000

<210> 603
<400> 603
000

<210> 604
<400> 604
000

<210> 605
<400> 605
000

<210> 606
<400> 606
000

<210> 607
<400> 607
000

<210> 608
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-21C8-Ab1 VH

<400> 608
caggtccaac tccagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagatg      60

tcctgcaagg cttctggcta caccttcacc agctactgga taacctgggt gaggcagagg     120

cctggacaag gccttgactg gattggagat atttatcctg gtggaggtgt tactaactac     180

aatgagaagt tcaagaccaa ggccacactg actgtagaca catcctccag cacagcctac     240

atgcacctca gcagcctgac atctgaggac tctgcggtct atttctgtgc gacagctcag     300

actacgtttg cttactgggg ccaagggact ctggtcactg tctctgca                  348


<210> 609
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-21C8-Ab1 VL

<400> 609
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gaacattgta cataataatg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct     300

cggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 610
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VH

<400> 610
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Arg Tyr 
            20                  25                  30          
Ile Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Thr Gly Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Glu Tyr Gly Tyr Asp Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala 
        115                 

<210> 611
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VH CDR1

<400> 611
Arg Tyr Ile Ile Asn 
1               5   

<210> 612
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VH CDR2

<400> 612
Val Ile Trp Thr Gly Gly Gly Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      



<210> 613
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VH CDR3

<400> 613
Glu Tyr Gly Tyr Asp Gly Ala Trp Phe Ala Tyr 
1               5                   10      

<210> 614
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VL

<400> 614
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 615
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VL CDR1

<400> 615
Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 616
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VL CDR2

<400> 616
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 617
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VL CDR3

<400> 617
Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   

<210> 618
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VH

<400> 618
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      60

acatgcactg tctctggctt ctcattaacc aggtatatta taaattgggt tcgccagcca     120

ccaggaaagg gtctggagtg gcttggagta atctggactg gtggaggcac agattataat     180

tcagctctca aatccagact gagcatcagc aaagacaact ccaagagtca agttttctta     240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag agagtatggt     300

tacgacgggg cctggtttgc ttactggggc caagggactc ttgtcactgt ctctgca        357


<210> 619
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3101E3-Ab1 VL

<400> 619
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gaccattgta catagtaatg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg     300

tacacgttcg gaggggggac caagctggaa ataaaa                               336


<210> 620
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VH

<400> 620
Gln Val Ser Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Asp 
        35                  40                  45              
Trp Leu Thr His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Gly 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  
Phe Leu Glu Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Gly Asp Tyr Tyr Gly Thr Arg Gly Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             

<210> 621
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VH CDR1

<400> 621
Thr Phe Gly Met Gly Val Gly 
1               5           

<210> 622
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VH CDR2

<400> 622
His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Gly Leu Lys Ser 
1               5                   10                  15      



<210> 623
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VH CDR3

<400> 623
Ile Gly Asp Tyr Tyr Gly Thr Arg Gly Tyr Phe Asp Val 
1               5                   10              

<210> 624
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VL

<400> 624
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Met Ser Leu Gly 
1               5                   10                  15      
Gln Thr Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Glu Arg Phe Ile Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Asn Val Gln Ser Glu Asp Leu Thr Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      
His Tyr Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 625
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VL CDR1

<400> 625
Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn His Leu 
1               5                   10                  15      
Ala 
    

<210> 626
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VL CDR2

<400> 626
Phe Ala Ser Thr Arg Glu Ser 
1               5           

<210> 627
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VL CDR3

<400> 627
Gln Gln His Tyr Ser Thr Pro Tyr Thr 
1               5                   

<210> 628
<211> 369
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VH

<400> 628
caggtttctc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg      60

acttgctctt tctctgggtt ttcactgagc acttttggta tgggtgtagg ctggattcgt     120

cagccttcag ggaagggtct ggactggctg acacacattt ggtgggatga tgataagtac     180

tataatccag gcctgaagag tcgcctcaca atctccaagg atacctccaa aaaccaggta     240

ttcctcgaga tcgccaatgt ggacactgca gatactgcca catattactg tgcgcgaata     300

ggagattact acggtactag agggtacttc gatgtctggg gcacagggac cacggtcacc     360

gtctcctca                                                             369


<210> 629
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103D9-Ab1 VL

<400> 629
gacattgtga tgacacagtc tccatcctcc ctgactatgt cactaggaca gacggtcact      60

atgagctgca agtccagtca gagcctttta aatagtagca atcaaaagaa ccatctggcc     120

tggtaccagc agagaccagg acagtctccc aaacttctgg tatactttgc atccactagg     180

gaatctgggg tccctgagcg cttcataggc ggtggatctg ggacagattt cactcttacc     240

atcagcaatg tgcagtctga agacctgaca gattacttct gtcagcaaca ttatagcact     300

ccgtacacgt tcggaggggg gaccaagctg gaaataaaa                            339


<210> 630
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VH

<400> 630
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Met Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Asp Trp His Trp Ile Arg His Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Arg Ile Ser Ile Thr His Asp Thr Ser Lys Asn His Phe Phe 
65                  70                  75                  80  
Leu Lys Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Thr Val Asp Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala 
        115             

<210> 631
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VH CDR1

<400> 631
Ser Gly Tyr Asp Trp His 
1               5       

<210> 632
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VH CDR2

<400> 632
Tyr Ile Thr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 633
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VH CDR3

<400> 633
Asp Thr Val Asp Ala Trp Phe Ala Tyr 
1               5                   

<210> 634
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VL

<400> 634
Asp Val Leu Met Thr Gln Ala Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 635
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VL CDR1

<400> 635
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asp Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 636
<400> 636
000

<210> 637
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VL CDR3

<400> 637
Phe Gln Gly Ser His Val Pro Pro Thr 
1               5                   

<210> 638
<211> 354
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VH

<400> 638
gatgtgcagc ttcaggagtc aggacctggc atggtgaaac cttctcagtc actttccctc      60

acctgcactg tcactggcta ctccatcacc agtggttatg actggcactg gatccgacat     120

tttccaggaa acaaactgga gtggatgggc tacataacct acagtggtag cactaactac     180

aacccatccc tcaaaagtcg aatctccatc actcatgaca catctaagaa ccatttcttc     240

ctgaagttga cttctgtgac tactgaggac acagccacat attactgtgc aagagacacg     300

gtagacgcct ggtttgctta ctggggccag gggactctgg tcactgtctc tgca           354


<210> 639
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3103G12-Ab2 VL

<400> 639
gatgttttga tgacccaagc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcgtgca gatctagtca gagcattgta catagtaatg gagacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct     300

ccgacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 640
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3104F12-Ab2 VH

<400> 640
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Val Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Phe 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Asp 
        35                  40                  45              
Trp Leu Thr His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  
Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Gly Asp Phe Tyr Gly Ser Arg Gly Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             

<210> 641
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3104F12-Ab2 VH CDR1

<400> 641
Thr Phe Gly Leu Gly Val Gly 
1               5           

<210> 642
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3104F12-Ab2 VH CDR2

<400> 642
His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      



<210> 643
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3104F12-Ab2 VH CDR3

<400> 643
Ile Gly Asp Phe Tyr Gly Ser Arg Gly Tyr Phe Asp Val 
1               5                   10              

<210> 644
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3104F12-Ab2 VL

<400> 644
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      
Gln Lys Val Thr Leu Arg Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Leu Cys Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      
His Tyr Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 645
<400> 645
000

<210> 646
<400> 646
000

<210> 647
<400> 647
000

<210> 648
<211> 369
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3104F12-Ab2 VH

<400> 648
caggttactc tgaaagagtc tggccctgga atagtgcagc cctcccagac cctcagtctg      60

acttgctctt tctctggatt ttcactgaac acttttggtt tgggtgtagg ctggattcgt     120

cagccttcag ggaagggtct ggactggctg acacacattt ggtgggatga tgataagtac     180

tataatccag ccctgaagag tcggctcaca atctccaagg atacctccaa aaaccaggta     240

ttcctcaaga tcgccaatgt ggacactgca gatactgcca catactactg tgctcgaata     300

ggcgatttct acggtagtag aggatatttc gatgtctggg gcacagggac cacggtcacc     360

gtctcctca                                                             369


<210> 649
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3104F12-Ab2 VL

<400> 649
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagttggaca gaaggtcact      60

ttgaggtgca agtccagtca gagcctttta aatagtagta atcaaaagaa ccatttggcc     120

tggtaccagc agaaaccagg acagtctcct aaacttctgc tatgctttgc atccactagg     180

gaatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc     240

atcagtagtg tgcaggctga agacctggca gattacttct gtcagcaaca ttatagcact     300

ccgtacacgt tcggaggggg gaccaagctg gaaataaaa                            339


<210> 650
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106C5-Ab1 VH

<400> 650
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Thr His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Pro Ser Lys Asn Gln Val 
65                  70                  75                  80  
Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Gly Asp Tyr Tyr Gly Ser Arg Gly Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             

<210> 651
<400> 651
000

<210> 652
<400> 652
000

<210> 653
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106C5-Ab1 VH CDR3

<400> 653
Ile Gly Asp Tyr Tyr Gly Ser Arg Gly Tyr Phe Asp Val 
1               5                   10              

<210> 654
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106C5-Ab1 VL

<400> 654
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      
Gln Lys Val Thr Met Ser Cys Lys Ser Arg Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      
His Tyr Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 655
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106C5-Ab1 VL CDR1

<400> 655
Lys Ser Arg Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn His Leu 
1               5                   10                  15      
Ala 
    

<210> 656
<400> 656
000

<210> 657
<400> 657
000

<210> 658
<211> 368
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106C5-Ab1 VH

<400> 658
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg      60

acttgttctt tctctgggtt ttcactgagt acttttggta tgggtgtagg ctggattcgt     120

cagccttcag ggaagggtct ggagtggcta acacacattt ggtgggatga tgataagtac     180

tataacccag ccctgaagag tcggctcaca atctccaggg atccctccaa aaaccaggta     240

ttctcaagat cgccaatgtg gacactgcag atactgccac atactactgt gctcgaatag     300

gggattacta cggtagtaga ggatacttcg atgtctgggg cacagggacc acggtcaccg     360

tctcctca                                                              368


<210> 659
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106C5-Ab1

<400> 659
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact      60

atgagctgca agtccaggca gagcctttta aatagtagta atcaaaagaa tcatttggcc     120

tggtaccagc agaaaccagg acagtctcct aaacttctgg tatactttgc atccactagg     180

gaatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc     240

atcagcagtg tgcaggctga agacctggca gattacttct gtcagcaaca ttatagcact     300

ccgtacacgt tcgggggggg gaccaagctg gaaataaaa                            339


<210> 660
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VH

<400> 660
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Val Lys Asp Asp 
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Gly Leu Thr Ser Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Ala Gly Thr Ser Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser 
        115                 

<210> 661
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VH CDR1

<400> 661
Asp Asp Tyr Met His 
1               5   

<210> 662
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VH CDR2

<400> 662
Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 663
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VH CDR3

<400> 663
Ala Gly Thr Ser Pro Tyr Tyr Phe Asp Tyr 
1               5                   10  

<210> 664
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VL

<400> 664
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Val Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 665
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VL CDR1

<400> 665
Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      

<210> 666
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VL CDR2

<400> 666
Ser Ala Ser Tyr Arg Tyr Ser 
1               5           

<210> 667
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VL CDR3

<400> 667
Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   

<210> 668
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VH

<400> 668
gaggttcagc tgcagcagtc tggggctgag cttgtgaggc caggggcctc agtcaagttg      60

tcctgcacag cttctggctt taacgttaaa gacgactata tgcactgggt gaagcagagg     120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat     180

gcctcgaagt tccagggcaa ggccacttta acagcagaca catcctccaa cacagcctac     240

ctgcagctca gcggcctgac atctgtggac actgccgtct attactgtac tacagccggt     300

actagcccgt actactttga ctactggggc caaggcacca ctctcacagt ctcctcc        357


<210> 669
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3106F2-Ab1 VL

<400> 669
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc      60

gtcacctgca aggccagtca gaatgtggga actaatgtag cctggtatca acagaaagta     120

ggacaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat     180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct     240

gaagacttgg cagactattt ctgtcagcaa tataacagct atcctctcac gttcggctcg     300

gggacaaagt tggaaataaa a                                               321


<210> 670
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VH

<400> 670
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          
Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Ser Ser Tyr Ile Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ser Asn Tyr Ala Met Asp Ser Trp Gly Gln Gly Thr Ser 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 671
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VH CDR1

<400> 671
Asp Tyr Phe Met Asn 
1               5   

<210> 672
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VH CDR2

<400> 672
Asp Ile Asn Pro Asn Asn Gly Gly Ser Ser Tyr Ile Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 673
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VH CDR3

<400> 673
Gly Ser Asn Tyr Ala Met Asp Ser 
1               5               

<210> 674
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VL

<400> 674
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asp Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 675
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VL CDR1

<400> 675
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 676
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VL CDR2

<400> 676
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 677
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VL CDR3

<400> 677
Lys Gln Ser Tyr Asp Leu Trp Thr 
1               5               

<210> 678
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VH

<400> 678
gaggtccagc tgcaacaatc tggacctgaa ctggtgaagc ctggggcttc agtgaagata      60

tcctgtaagg cttctggata cacgttcagt gactacttca tgaactgggt gaagcagagt     120

catggaaaaa gccttgagtg gattggagat attaatccta acaatggtgg ttctagctac     180

atccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccac cacagcctat     240

atggagctcc gcagcctgac atctgaggac tcagcagtct attactgtgc aagaggtagc     300

aactatgcta tggactcctg gggtcaggga acctcagtca ccgtctcctc a              351


<210> 679
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3112H1-Ab1 VL

<400> 679
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact      60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccggaagaa ctacttggct     120

tggtaccagc agaaaccagg acagtctcct aaactgctga tctactgggc atccactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc     240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttatgatctg     300

tggacgttcg gtgggggcac caagctggaa atcaaa                               336


<210> 680
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3107E6-Ab1 VH

<400> 680
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Thr His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ala Ser Lys Asn Gln Met 
65                  70                  75                  80  
Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      
Cys Ala Arg Ile Gly Asp Tyr Tyr Gly Ser Arg Gly Phe Phe Asp Val 
            100                 105                 110         
Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             

<210> 681
<400> 681
000

<210> 682
<400> 682
000

<210> 683
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3107E6-Ab1 VH CDR3

<400> 683
Ile Gly Asp Tyr Tyr Gly Ser Arg Gly Phe Phe Asp Val 
1               5                   10              

<210> 684
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3107E6-Ab1 VL

<400> 684
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      
Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      
His Tyr Ser Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 685
<400> 685
000

<210> 686
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3107E6-Ab1 VL CDR2

<400> 686
Phe Ala Ser Thr Arg Asp Ser 
1               5           

<210> 687
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3107E6-Ab1 VL CDR3

<400> 687
Gln Gln His Tyr Ser Thr Pro Tyr Thr 
1               5                   

<210> 688
<211> 369
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3107E6-Ab1 VH

<400> 688
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg      60

acttgttctt tctctgggtt ttcactgagc acttttggta tgggtgtagg ctggattcgt     120

cagccttcag ggaagggtct ggagtggctg acacacattt ggtgggatga tgataaatac     180

tataacccag cccttaagag tcggctcaca atctccaagg atgcctccaa aaaccagatg     240

ttcctcaaga tcgccaatgt ggacactgca gatactgcca catacttctg tgctcgaata     300

ggggattact acggtagtag agggttcttc gatgtctggg gcacagggac cacggtcacc     360

gtctcctca                                                             369


<210> 689
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3107E6-Ab1 VL

<400> 689
gacattgtga tgacacagtc tccatcctcc ctggccatgt cagtaggaca gaaggtcact      60

atgagctgca agtccagtca gagcctttta aatagtagca atcaaaagaa ccatttggcc     120

tggtatcagc agaaaccagg acagtctcct aaacttctgg tatactttgc atccactagg     180

gactctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc     240

atcagcagtg tgcaggctga ggacctggca gattacttct gtcagcaaca ttatagcact     300

ccgtacacgt tcggaggggg gaccaagctg gaaataaaa                            339


<210> 690
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VH

<400> 690
Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Ala Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Asp Gly Gly Thr Tyr Thr Phe Tyr Ser Asp Asn Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Ala Gly Ser Gly His Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 691
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VH CDR1

<400> 691
Asn Tyr Ala Met Ser 
1               5   

<210> 692
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VH CDR2

<400> 692
Thr Ile Ser Asp Gly Gly Thr Tyr Thr Phe Tyr Ser Asp Asn Val Lys 
1               5                   10                  15      
Gly 
    

<210> 693
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VH CDR3

<400> 693
Ala Gly Ser Gly His 
1               5   

<210> 694
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VL

<400> 694
Asp Val Val Met Thr Gln Thr Pro Arg Thr Leu Ser Val Ile Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Val Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr Tyr Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 695
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VL CDR1

<400> 695
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Ser 
1               5                   10                  15      



<210> 696
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VL CDR2

<400> 696
Leu Val Ser Lys Val Asp Ser 
1               5           

<210> 697
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VL CDR3

<400> 697
Trp Gln Gly Thr Tyr Phe Pro Arg Thr 
1               5                   

<210> 698
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VH

<400> 698
gaactgcagc tggtggagtc tgggggaggc ttagtgaggc ctggagggtc cctgaaactc      60

tcctgtgcaa cctctggatt cactttcaga aactatgcca tgtcttgggt tcgccagact     120

ccggcaaaga ggctggagtg ggtcgcaacc attagtgatg gtggtactta caccttctat     180

tcagacaatg taaagggccg attcaccatc tccagagaca atgtcaagaa caccttgtac     240

cttcaaatga gccatctgaa gtctgaggac acagccatgt attactgttc aagagccggc     300

tctggccact ggggccaagg caccactctc acagtctcct ca                        342


<210> 699
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7079-3108C10-Ab2 VL

<400> 699
gatgttgtga tgacccagac tccacgcact ttgtcggtaa tcattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata cttgagttgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaagtggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac atattttcct     300

cggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 700
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VH

<400> 700
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          
Tyr Ile His Trp Met Lys Gln Arg Pro Gly Gln Gly Pro Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Arg Gly Tyr Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Ala Gln Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Trp Glu Thr Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ala 
        115         

<210> 701
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VH CDR1

<400> 701
Thr Tyr Tyr Ile His 
1               5   

<210> 702
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VH CDR2

<400> 702
Trp Ile Tyr Pro Gly Arg Gly Tyr Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210> 703
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VH CDR3

<400> 703
Asp Trp Glu Thr Gly Phe Pro Tyr 
1               5               

<210> 704
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VL

<400> 704
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Gly 
            20                  25                  30          
Gly Asp Ser Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Asp Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Gly 
                85                  90                  95      
Glu Asp Pro Phe Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105                 110     

<210> 705
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VL CDR1

<400> 705
Lys Ala Ser Gln Ser Val Asp Tyr Gly Gly Asp Ser Trp Leu Asn 
1               5                   10                  15  

<210> 706
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VL CDR2

<400> 706
Ala Ala Ser Asn Leu Asp Ser 
1               5           

<210> 707
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VL CDR3

<400> 707
Gln Gln Ser Gly Glu Asp Pro Phe Thr 
1               5                   

<210> 708
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VH

<400> 708
caggtccagc tgcagcagtc tggacctgaa ctggtgaagc ctggggcttc agtgaagata      60

tcctgcaagg cttctggcta cagcttcaca acctactata tacactggat gaagcagagg     120

cctggacagg gacctgagtg gattggatgg atttatcctg gaaggggtta tactaagtac     180

aatgagaagt tcaaggacaa ggccgcacag acggcagaca catcctccaa cactgcctac     240

atgcagctca gcagcctaag atctgaggac tctgcggtct attactgtgc aagagactgg     300

gaaaccggat ttccttactg gggccaaggt actctggtca ctgtctctgc a              351


<210> 709
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8030-6106F5-Ab1 VL

<400> 709
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      60

atctcctgca aggccagcca aagtgttgat tatggtggtg atagttggct gaactggtac     120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagattct     180

gggatcccag ccaggtttgg tggcagtggg tctgggacag acttcaccct caacatccat     240

cctgtggagg aggaggatgc tgcaacctat tactgtcaac aaagtggaga ggatccgttc     300

acgttcggag gggggaccaa tctggaaata aaa                                  333


<210> 710
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VH

<400> 710
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ile Thr His Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         
Ser Ser 
        

<210> 711
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VH CDR1

<400> 711
Ser Tyr Trp Met Asn 
1               5   

<210> 712
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VH CDR2

<400> 712
Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 713
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VH CDR3

<400> 713
Thr His Tyr Asp Tyr 
1               5   

<210> 714
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VL

<400> 714
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Arg 
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 715
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VL CDR1

<400> 715
Arg Ala Ser Gln Ser Ile Gly Thr Arg Ile His 
1               5                   10      

<210> 716
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VL CDR2

<400> 716
Tyr Ala Ser Glu Ser Ile Ser 
1               5           

<210> 717
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VL CDR3

<400> 717
Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   

<210> 718
<211> 342
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VH

<400> 718
caggttcagc tgcagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt      60

tcctgcaaag cttctggcta cgcattcagt agctactgga tgaactgggt gaagcagagg     120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac     180

aacggaaagt tcaagggcaa ggccacactg actgcagaca gatcctccag cacagcctac     240

atgcagctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aattacgcac     300

tatgactact ggggccaagg caccactctc acagtctcct ca                        342


<210> 719
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8031-6207G10-Ab1 VL

<400> 719
gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga tagagtcagt      60

ttctcctgca gggccagtca gagcattggc acaaggatac actggtatca gcaaagaaca     120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gaccccttcc     180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct     240

gaagatattg cagattatta ctgtcaacaa agtaatagtt ggccactcac gttcggtgct     300

gggaccaagc tggagctgaa a                                               321


<210> 720
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301A10-Ab2 VH

<400> 720
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Glu Ser Tyr Tyr Gly Asp Tyr Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         
Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 721
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301A10-Ab2 VH CDR1

<400> 721
Ser Tyr Gly Ile Ser 
1               5   

<210> 722
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301A10-Ab2 VH CDR2

<400> 722
Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 723
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301A10-Ab2 VH CDR3

<400> 723
Glu Ser Tyr Tyr Gly Asp Tyr Asp Trp Tyr Phe Asp Val 
1               5                   10              

<210> 724
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301A10-Ab2 VL

<400> 724
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser His Ser Ile Glu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Cys Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              
Pro Lys Phe Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 725
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301A10-Ab2 VL CDR1

<400> 725
Arg Ser Ser His Ser Ile Glu His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 726
<400> 726
000

<210> 727
<400> 727
000

<210> 728
<211> 366
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301A10-Ab2 VH

<400> 728
caggttcagc tgcagcagtc tggagctgaa ctggcgaggc ctggggcttc agtgaagctg      60

tcctgcaagg cttctggcta caccttcaca agctatggta tcagctgggt gaagcagaga     120

actggacagg gccttgagtg gattggagag atttatccta gaagtggtaa tacttactac     180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac     240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagtgagagc     300

tactatggtg actacgactg gtacttcgat gtctggggca ctgggaccac ggtcaccgtc     360

tcctca                                                                366


<210> 729
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301A10-Ab2 VL

<400> 729
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca cagcattgaa catagtaatg gaaacaccta tttagaatgg     120

tgcctgcaga aaccaggcca gcctccaaag ttcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaggatc     240

agtagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct     300

ccgacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 730
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301C8-Ab2 VH

<400> 730
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Glu Ser Tyr Tyr Gly Asp Tyr Ala Trp Tyr Phe Asp Val Trp 
            100                 105                 110         
Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 731
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301C8-Ab2 VH CDR1

<400> 731
Thr Tyr Gly Ile Ser 
1               5   

<210> 732
<400> 732
000

<210> 733
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301C8-Ab2 VH CDR3

<400> 733
Glu Ser Tyr Tyr Gly Asp Tyr Ala Trp Tyr Phe Asp Val 
1               5                   10              

<210> 734
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301C8-Ab2 VL

<400> 734
Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp His Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 735
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301C8-Ab2 VL CDR1

<400> 735
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 736
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301C8-Ab2 VL CDR2

<400> 736
Glu Val Ser Asn Arg Phe Ser 
1               5           

<210> 737
<400> 737
000

<210> 738
<211> 366
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301C8-Ab2 VH

<400> 738
caggttcagc tgcagcagtc tggagctgaa ctggcgaggc ctgggacttc agtgaagctg      60

tcctgcaagg cttctggcta caccttcaca acctatggta taagctgggt gaagcagaga     120

actggacagg gccttgagtg gattggagag atttatccta gaagtggtaa tacttactac     180

aatgagaaat tcaagggcaa ggccacactg actgcagaca agccctccag cacagcgtac     240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagtgagagt     300

tactatggtg actacgcctg gtacttcgat gtctggggca cagggaccac ggtcaccgtc     360

tcctca                                                                366


<210> 739
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301C8-Ab2 VL

<400> 739
gatgttttga tgacccaaat tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg     120

cacctgcaga aaccaggcca gtctccaaag ctcctgatct acgaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaatatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct     300

ccgacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 740
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301G2-Ab2 VH

<400> 740
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Ile Gly Val Thr Asn Tyr Asn Pro Lys Phe 
    50                  55                  60                  
Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Ser Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Thr Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Gly Ser Asn Pro Leu Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         

<210> 741
<400> 741
000

<210> 742
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301G2-Ab2 VH CDR2

<400> 742
Asp Ile Asn Pro Asn Ile Gly Val Thr Asn Tyr Asn Pro Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210> 743
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301G2-Ab2 VH CDR3

<400> 743
Gly Gly Gly Ser Asn Pro Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10              

<210> 744
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301G2-Ab2 VL

<400> 744
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asp Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 745
<400> 745
000

<210> 746
<400> 746
000

<210> 747
<400> 747
000

<210> 748
<211> 366
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301G2-Ab2 VH

<400> 748
gaggtccaac tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagata      60

tcctgtaagg cttctggata cacgttcact gactacttca tgaactgggt gaagcagagc     120

catggaaaga gccttgagtg gattggagat attaatccta acattggtgt tactaactac     180

aacccgaagt tcaaggacag ggccacattg actgtagaca agtcctccag ctcagcctac     240

atggagctcc gcagcctgac atctgaggac tctacagtct attactgtgc aagaggggga     300

gggagtaatc ccctttacta tgctatggac tactggggtc aaggaacctc agtcaccgtc     360

tcctca                                                                366


<210> 749
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6301G2-Ab2 VL

<400> 749
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact      60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct     120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc     240

atcagcagtg tgcaggctga agacctggca gtttatttct gcaagcaatc ttatgatctg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 750
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6304F3-Ab1 VH

<400> 750
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Gly Val Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Glu Ser Tyr Tyr Gly Asp Tyr Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         
Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 751
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6304F3-Ab1 VH CDR1

<400> 751
Ser Tyr Gly Val Ser 
1               5   

<210> 752
<400> 752
000

<210> 753
<400> 753
000

<210> 754
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6304F3-Ab1 VL

<400> 754
Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      
Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Pro Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 755
<400> 755
000

<210> 756
<400> 756
000

<210> 757
<400> 757
000

<210> 758
<211> 366
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6304F3-Ab1 VH

<400> 758
caggttcagc tgcagcagtc tggagctgag ctggcgagac ctggggcttc agtgaagctg      60

tcctgcaagg cttctggcta caccttcaca agctatggtg taagctgggt gaagcagaga     120

actggacagg gccttgagtg gattggagag atttatccta gaagtggtaa tacttactac     180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac     240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagtgagagc     300

tactatggtg actacgactg gtatttcgat gtctggggca cagggaccac ggtcaccgtc     360

tcctca                                                                366


<210> 759
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6304F3-Ab1 VL

<400> 759
gatgttttga tgacccaaat tccactctcc ctgcctgtca gtcctggaga tcaagtttcc      60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag cccctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct     300

ccgacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 760
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6307F1-Ab2 VH

<400> 760
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Glu Ser Tyr Tyr Gly Asp Tyr Ala Trp Tyr Phe Asp Val Trp 
            100                 105                 110         
Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 761
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6307F1-Ab2 VH CDR1

<400> 761
Ser Tyr Gly Met Ser 
1               5   

<210> 762
<400> 762
000

<210> 763
<400> 763
000

<210> 764
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6307F1-Ab2 VL

<400> 764
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 765
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6307F1-Ab2 VL CDR1

<400> 765
Arg Ser Ser Gln Ser Val Val His Ser Asn Gly Ile Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 766
<400> 766
000

<210> 767
<400> 767
000

<210> 768
<211> 366
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6307F1-Ab2 VH

<400> 768
caggttcagc tgcagcagtc tggagctgag ctggcgaggc ctggggcttc agtgaagctg      60

tcctgcaagg cttctggcta caccttcaca agctatggta tgagttgggt gaaacagaga     120

actggacagg gccttgagtg gattggagag atttatccta gaagtggtaa tacttactac     180

aatgagaagt tcaagggcaa ggccacactg acttcagaca aatcctccag cacatcatac     240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagtgagagc     300

tactatggtg actacgcctg gtacttcgat gtctggggca cagggaccac ggtcaccgtc     360

tcctca                                                                366


<210> 769
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6307F1-Ab2 VL

<400> 769
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagcgttgta catagtaatg gaatcaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga catatttcac actcaagatc     240

agcagagtgg aggctgagga tcttggagtt tattactgct ttcaaggttc acatgttcct     300

ccgacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 770
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6313G2-Ab1 VH

<400> 770
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Val Thr Ser Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr Gly Tyr Tyr Gly Thr Ser Leu Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             

<210> 771
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6313G2-Ab1 VH CDR1

<400> 771
Asp Tyr Tyr Met Asn 
1               5   

<210> 772
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6313G2-Ab1 VH CDR2

<400> 772
Asp Ile Asp Pro Asn Asn Gly Val Thr Ser Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 773
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6313G2-Ab1 VH CDR3

<400> 773
Thr Gly Tyr Tyr Gly Thr Ser Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  

<210> 774
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6313G2-Ab1 VL

<400> 774
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asp Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 775
<400> 775
000

<210> 776
<400> 776
000

<210> 777
<400> 777
000

<210> 778
<211> 369
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6313G2-Ab1 VH

<400> 778
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagata      60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc     120

catggaaaga gccttgagtg gattggagat attgatccta acaatggtgt tactagttac     180

agccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac     240

atggagctcc gcagcctgac atctgaagac tctgcagtct attactgtgc aaggacgggg     300

tactacggta cttctctata ctatgctatg gactactggg gtcaaggaac ctcagtcacc     360

gtctcctca                                                             369


<210> 779
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6313G2-Ab1 VL

<400> 779
gacattgtga tgtcacagtc gccatcctcc ctggctgtgt cagcaggaga gaaggtcact      60

atgaactgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct     120

tggtaccagc agaaaccagg gcagtctcca aaactactga tctactgggc atccactagg     180

gaatctgggg tccctgatcg cttcataggc agtggatctg ggacaggttt cactctcacc     240

attagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttatgatctg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 780
<400> 780
000

<210> 781
<400> 781
000

<210> 782
<400> 782
000

<210> 783
<400> 783
000

<210> 784
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8032-6314A3-Ab3 VL

<400> 784
Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Pro Gly 
1               5                   10                  15      
Asp Gln Val Phe Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Pro Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 785
<400> 785
000

<210> 786
<400> 786
000

<210> 787
<400> 787
000

<210> 788
<400> 788
000

<210> 789
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8032-6314A3-Ab3 VL

<400> 789
gatgttttga tgacccaaat tccactctcc ctgcctgtca gtcctggaga tcaagttttc      60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg     120

tacctgcaga aaccaggcca gtctccaaag cccctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc     240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct     300

ccgacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 790
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VH

<400> 790
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Tyr Pro Gly Asn Gly Asp Val Asp Tyr Ser Glu Ile Phe 
    50                  55                  60                  
Lys Asn Lys Ala Lys Met Thr Val Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr His Cys 
                85                  90                  95      
Val Leu Gly Gln Thr Ser Phe Gly His Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ala 
        115     

<210> 791
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VH CDR1

<400> 791
Asn Tyr Trp Ile Thr 
1               5   

<210> 792
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VH CDR2

<400> 792
Asp Ile Tyr Pro Gly Asn Gly Asp Val Asp Tyr Ser Glu Ile Phe Lys 
1               5                   10                  15      
Asn 
    

<210> 793
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VH CDR3

<400> 793
Gly Gln Thr Ser Phe Gly His 
1               5           

<210> 794
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VL

<400> 794
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Val His Val 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Thr Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 795
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VL CDR1

<400> 795
Arg Ser Ser Gln Ser Val Val His Val Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      



<210> 796
<400> 796
000

<210> 797
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VL CDR3

<400> 797
Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   

<210> 798
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VH

<400> 798
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagatg      60

tcctgcaagg cttctggcta caccttcacc aactactgga ttacctgggt aaaacagagg     120

cctggacaag gccttgagtg gattggggat atttatcctg gtaatggtga tgttgactac     180

agtgagatct tcaagaataa ggccaaaatg actgtagaca catcctccac cacagcctac     240

atgcagctca gcagcctgac atctgaggac tctgcggtct atcactgtgt cttgggtcag     300

acttcctttg gtcattgggg ccaagggact ctggtcactg tctctgca                  348


<210> 799
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6401F2-Ab1 VL

<400> 799
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      60

atctcttgca gatctagtca gagtgttgtg catgttaatg gaaacaccta tttagattgg     120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt     180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac gctcaggatc     240

accagagtgg aggctgagga tctgggaatt tattactgtt ttcaaggttc acatgttcct     300

cggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 800
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E2-Ab2 VH

<400> 800
Glu Val Gln Leu Gln His Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Ser Asn Tyr Tyr Ala Met Asp Ser Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser 
        115                 

<210> 801
<400> 801
000

<210> 802
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E2-Ab2 VH CDR2

<400> 802
Asp Ile Asn Pro Asn Asn Gly Asp Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 803
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E2-Ab2 VH CDR3

<400> 803
Ser Gly Ser Asn Tyr Tyr Ala Met Asp Ser 
1               5                   10  

<210> 804
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E2-Ab2 VL

<400> 804
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asp Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 805
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E2-Ab2 VL CDR1

<400> 805
Lys Ser Ser Gln Ser Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 806
<400> 806
000

<210> 807
<400> 807
000

<210> 808
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E2-Ab2 VH

<400> 808
gaggtccagc tgcaacattc tggacctgac ctggtgaagc ctggggcttc agtgaagata      60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaaacagagc     120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtga tactacctac     180

aaccagaagt tcaagggcag ggccacattg actgtagaca agtcctccag cacagcctac     240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagatcgggg     300

agtaattact atgctatgga ctcctggggt caaggaacct cagtcaccgt ctcctca        357


<210> 809
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E2-Ab2 VL

<400> 809
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gagggtcact      60

atgagctgca aatccagtca gagtctgttc aacagtagaa cccgaaagaa ctacttggct     120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg     180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cagtctcaac     240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttatgatctg     300

tggacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 810
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VH

<400> 810
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Val Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Ser Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Lys Leu Asp Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Val Arg Ala Asp Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 811
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VH CDR1

<400> 811
Ser Gly Tyr Tyr Trp Asn 
1               5       

<210> 812
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VH CDR2

<400> 812
Tyr Ile Ser Ser Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      



<210> 813
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VH CDR3

<400> 813
Ala Asp Asn Tyr 
1               

<210> 814
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VL

<400> 814
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Val Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 815
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VL CDR1

<400> 815
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Glu Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 816
<400> 816
000

<210> 817
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VL CDR3

<400> 817
Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   

<210> 818
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VH

<400> 818
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac ctgttcagtc tttgtctctc      60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag     120

tttccaggaa acaaactgga atggatgggc tacataagct ccgatggtag caataactac     180

aacccatctc tcaaaaatcg aatctccatc tctcgtgaca catctaagaa ccagtttttc     240

ctgaagttgg attctgtgac tactgaggac acagccacat attactgtgt aagagcggac     300

aactactggg gccaaggcac cactctcaca gtctcctcg                            339


<210> 819
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6402E10-Ab1 VL

<400> 819
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatagtgatg gagagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaagtggac     180

tctggagtcc ctgacaggtt cactggcaga ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggcac acattttcct     300

cagacgttcg gtggaggcac caagctggaa atcaag                               336


<210> 820
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VH

<400> 820
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Thr Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 821
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VH CDR1

<400> 821
Thr Tyr Ala Met Asn 
1               5   

<210> 822
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VH CDR2

<400> 822
Arg Ile Arg Ser Lys Ser Asn Asn Tyr Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 823
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VH CDR3

<400> 823
Thr Met Asp Tyr 
1               

<210> 824
<211> 105
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VL

<400> 824
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      
Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile His 
        35                  40                  45              
Ser Thr Phe Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Tyr Thr Phe 
                85                  90                  95      
Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 

<210> 825
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VL CDR1

<400> 825
Ser Ala Ser Ser Ser Ile Ser Tyr Met His 
1               5                   10  

<210> 826
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VL CDR2

<400> 826
Ser Thr Phe Asn Leu Ala Ser 
1               5           

<210> 827
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VL CDR3

<400> 827
His Gln Trp Ser Ser Tyr Tyr Thr 
1               5               

<210> 828
<211> 345
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VH

<400> 828
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc      60

tcatgtgcag cctctggatt cagtttcaat acctacgcca tgaactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttatacaaca     180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc agaaagcatg     240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgaga     300

actatggact actggggtca aggaacctca gtcaccgtct cctca                     345


<210> 829
<211> 315
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403A4-Ab1 VL

<400> 829
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga ggagatcacc     60

ctaacctgca gtgccagttc gagtataagt tacatgcact ggtaccagca gaagtcaggc    120

acttctccca aactcttgat tcatagcaca ttcaacctgg cttctggagt cccttctcgc    180

ttcagtggca gtgggtctgg gaccttttat tctctcacaa tcagcagtgt ggaggctgaa    240

gatgctgccg attattactg ccatcagtgg agtagttatt acacgttcgg aggggggacc    300

aagctggaaa taaaa                                                     315


<210> 830
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VH

<400> 830
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Ile Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Ile Arg Gly Asp Val Asn Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 831
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VH CDR1

<400> 831
Ser Ala Tyr Tyr Trp Asn 
1               5       

<210> 832
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VH CDR2

<400> 832
Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Ile Pro Ser Leu Lys Asn 
1               5                   10                  15      



<210> 833
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VH CDR3

<400> 833
Gly Asp Val Asn 
1               

<210> 834
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VL

<400> 834
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Gly 
            20                  25                  30          
Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      
Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 835
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VL CDR1

<400> 835
Lys Ser Ser Gln Ser Leu Leu Asp Gly Asp Gly Glu Thr Tyr Leu Asn 
1               5                   10                  15      



<210> 836
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VL CDR2

<400> 836
Leu Val Ser Lys Leu Asp Ser 
1               5           

<210> 837
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VL CDR3

<400> 837
Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   

<210> 838
<211> 339
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VH

<400> 838
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc      60

acctgctctg tcactggcta ctccatcacc agtgcttatt actggaactg gatccggcag     120

tttccaggaa acaaactgga atggatgggc tacataagct acgatggtag caataactac     180

atcccttctc tcaaaaatcg aatctccatc agtcgtgaca catctaagaa ccagtttttc     240

ctgaagttga attctgtgac tactgaggac acagccacat attactgtat aagaggggat     300

gttaactggg gccaaggcac cactctcaca gtctcctca                            339


<210> 839
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-8033-6403E11-Ab2 VL

<400> 839
gatgttgtga tgacccagac tccactcact ttgtcggtca ccattggaca accagcctcc      60

atctcttgca agtcaagtca gagcctctta gatggtgatg gagagacata tttgaattgg     120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtatc taaactggac     180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc     240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct     300

cagacgttcg gtggaggcac caagctggaa atcaaa                               336


<210> 840
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VH

<400> 840
Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val His Pro Lys Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Arg Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  
Val Tyr Leu Glu Met Asn Asn Leu Glu Ala Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      
Tyr Cys Val Arg Gly Gly Arg Glu Ala Met Asp Phe Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser 
        115                 

<210> 841
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 CDR1

<400> 841
Ser Tyr Ala Met His 
1               5   

<210> 842
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VH CDR2

<400> 842
Arg Ile Arg Ser Lys Arg Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 843
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VH CDR3

<400> 843
Gly Gly Arg Glu Ala Met Asp Phe 
1               5               

<210> 844
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VL

<400> 844
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210> 845
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VL CDR1

<400> 845
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  

<210> 846
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VL CDR2

<400> 846
Gly Thr Asn Asn Arg Ala Pro 
1               5           

<210> 847
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VL CDR3

<400> 847
Ala Leu Trp Tyr Ser Asn His 
1               5           

<210> 848
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VH

<400> 848
gaggtgcagc tggaggagtc tggtggagga ttggtgcacc ctaaaggatc attgaaactc      60

tcatgtgccg cctctggttt caccttcaat tcctatgcca tgcactgggt ccgccaggct     120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagaagtaa ttatgcaaca     180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagcatg     240

gtctatctgg aaatgaacaa cctggaagct gaggacacag ccacgtatta ctgtgtgaga     300

gggggacgag aggctatgga cttctggggt caaggaacct cagtcaccgt ctcctca        357


<210> 849
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACI-7067-4813-R4A-G7-rec1 VL

<400> 849
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc      60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa     120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt     180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca     240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ttgggtgttc     300

ggtggaggaa ccaaactgac tgtccta                                         327


<210> 850
<211> 60
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 850
Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              
Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys 
    50                  55                  60  

<210> 851
<211> 35
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 851
Glu Gln Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala 
1               5                   10                  15      
Val Ala Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr 
            20                  25                  30          
Gly Phe Val 
        35  

<210> 852
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region A_HC

<400> 852
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Leu 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 853
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region B_HC

<400> 853
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 854
<211> 105
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region C_LC

<400> 854
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
1               5                   10                  15      
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            20                  25                  30          
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        35                  40                  45              
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    50                  55                  60                  
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
65                  70                  75                  80  
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                85                  90                  95      
Asp Lys Lys Val Glu Pro Lys Ser Cys 
            100                 105 

<210> 855
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region D_HC

<400> 855
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 856
<211> 334
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region E_HC

<400> 856
Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr His Thr 
            100                 105                 110         
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    130                 135                 140                 
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
145                 150                 155                 160 
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                165                 170                 175     
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        195                 200                 205             
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    210                 215                 220                 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
225                 230                 235                 240 
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
                245                 250                 255     
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            260                 265                 270         
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        275                 280                 285             
Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    290                 295                 300                 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
305                 310                 315                 320 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330                 

<210> 857
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region F_HC

<400> 857
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 858
<211> 358
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region G_HC

<400> 858
Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu 
1               5                   10                  15      
Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
            20                  25                  30          
Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val 
        35                  40                  45              
Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu 
    50                  55                  60                  
Lys Glu Gln Pro Ala Leu Gln Asp Ser Arg Tyr Ala Leu Ser Ser Arg 
65                  70                  75                  80  
Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
                85                  90                  95      
Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
            100                 105                 110         
Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
        115                 120                 125             
Arg Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     
Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn 
            260                 265                 270         
Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         
Ser Leu Ser Pro Gly Lys 
        355             

<210> 859
<211> 95
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region H_LC

<400> 859
Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          
Thr Gln Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              
Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  
Ala Trp Ser Gln Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Gln Asn 
65                  70                  75                  80  
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
                85                  90                  95  

<210> 860
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region I_HC

<400> 860
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 861
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region J_HC

<400> 861
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Cys Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 862
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Region K_LC

<400> 862
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Cys Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ser 
            100                 105         

<210> 863
<211> 120
<212> PRT
<213> Mammalia


<220> 
<223> Binding Epitope

<400> 863
Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              
Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      
Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         
Leu Glu Asp Met Pro Val Asp Pro 
        115                 120 

