                         SEQUENCE LISTING

<110>  Ultimovacs AB
 
<120>  Vaccine Conjugates

<130>  27.18.132030/02

<150>  GB 1917699.9
<151>  2019-12-04

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Clostridium tetani

<400>  1

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Tyr Ala Arg Thr Glu Asp Phe Phe 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Leu His Glu Thr Asp Ser Ala Val 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Leu Ser Leu Gly Phe Leu Phe Leu 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Met Pro Glu Gly Asp Leu Val Tyr 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Val Phe Arg Gly Asn Lys Val Lys 
1               5                   


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val Tyr Asp Pro Leu 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Gly Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu 
1               5                   10                  15  


<210>  12
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Arg Trp Trp 
1               


<210>  13
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate I SLP

<400>  13

Ala Arg Trp Trp Asn Tyr Ala Arg Thr Glu Asp Phe Phe Gln Gln Gln 
1               5                   10                  15      


Pro Pro Pro Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val Tyr Asp 
            20                  25                  30          


Pro Leu 
        


<210>  14
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate II SLP

<400>  14

Ala Arg Trp Trp Leu Leu His Glu Thr Asp Ser Ala Val Ala Ala Ala 
1               5                   10                  15      


Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu 
            20                  25                  30      


<210>  15
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate III SLP

<400>  15

Ala Arg Trp Trp Ser Leu Ser Leu Gly Phe Leu Phe Leu Ala Ala Ala 
1               5                   10                  15      


Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala 
            20                  25                  30      


<210>  16
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate IV SLP

<400>  16

Ala Arg Trp Trp Gly Met Pro Glu Gly Asp Leu Val Tyr Thr Gly Asn 
1               5                   10                  15      


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser 
            20                  25              


<210>  17
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate V SLP

<400>  17

Ala Arg Trp Trp Lys Val Phe Arg Gly Asn Lys Val Lys Asn Tyr Thr 
1               5                   10                  15      


Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu 
            20                  25              


<210>  18
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Leu Ala Met Pro Phe Ala Thr Pro Met 
1               5                   


<210>  20
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Ala Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met 
1               5                   10                  15      


Pro Phe Ala Thr Pro Met Glu Ala Glu Leu Ala 
            20                  25          


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B Cell Epitope Containing Peptide

<400>  21

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ala Ala Lys Tyr Ala Arg Val Arg Ala Lys Cys 
            20                  25                  


<210>  22
<211>  858
<212>  PRT
<213>  Clostridium tetani

<400>  22

Ser Leu Thr Asp Leu Gly Gly Glu Leu Cys Ile Lys Ile Lys Asn Glu 
1               5                   10                  15      


Asp Leu Thr Phe Ile Ala Glu Lys Asn Ser Phe Ser Glu Glu Pro Phe 
            20                  25                  30          


Gln Asp Glu Ile Val Ser Tyr Asn Thr Lys Asn Lys Pro Leu Asn Phe 
        35                  40                  45              


Asn Tyr Ser Leu Asp Lys Ile Ile Val Asp Tyr Asn Leu Gln Ser Lys 
    50                  55                  60                  


Ile Thr Leu Pro Asn Asp Arg Thr Thr Pro Val Thr Lys Gly Ile Pro 
65                  70                  75                  80  


Tyr Ala Pro Glu Tyr Lys Ser Asn Ala Ala Ser Thr Ile Glu Ile His 
                85                  90                  95      


Asn Ile Asp Asp Asn Thr Ile Tyr Gln Tyr Leu Tyr Ala Gln Lys Ser 
            100                 105                 110         


Pro Thr Thr Leu Gln Arg Ile Thr Met Thr Asn Ser Val Asp Asp Ala 
        115                 120                 125             


Leu Ile Asn Ser Thr Lys Ile Tyr Ser Tyr Phe Pro Ser Val Ile Ser 
    130                 135                 140                 


Lys Val Asn Gln Gly Ala Gln Gly Ile Leu Phe Leu Gln Trp Val Arg 
145                 150                 155                 160 


Asp Ile Ile Asp Asp Phe Thr Asn Glu Ser Ser Gln Lys Thr Thr Ile 
                165                 170                 175     


Asp Lys Ile Ser Asp Val Ser Thr Ile Val Pro Tyr Ile Gly Pro Ala 
            180                 185                 190         


Leu Asn Ile Val Lys Gln Gly Tyr Glu Gly Asn Phe Ile Gly Ala Leu 
        195                 200                 205             


Glu Thr Thr Gly Val Val Leu Leu Leu Glu Tyr Ile Pro Glu Ile Thr 
    210                 215                 220                 


Leu Pro Val Ile Ala Ala Leu Ser Ile Ala Glu Ser Ser Thr Gln Lys 
225                 230                 235                 240 


Glu Lys Ile Ile Lys Thr Ile Asp Asn Phe Leu Glu Lys Arg Tyr Glu 
                245                 250                 255     


Lys Trp Ile Glu Val Tyr Lys Leu Val Lys Ala Lys Trp Leu Gly Thr 
            260                 265                 270         


Val Asn Thr Gln Phe Gln Lys Arg Ser Tyr Gln Met Tyr Arg Ser Leu 
        275                 280                 285             


Glu Tyr Gln Val Asp Ala Ile Lys Lys Ile Ile Asp Tyr Glu Tyr Lys 
    290                 295                 300                 


Ile Tyr Ser Gly Pro Asp Lys Glu Gln Ile Ala Asp Glu Ile Asn Asn 
305                 310                 315                 320 


Leu Lys Asn Lys Leu Glu Glu Lys Ala Asn Lys Ala Met Ile Asn Ile 
                325                 330                 335     


Asn Ile Phe Met Arg Glu Ser Ser Arg Ser Phe Leu Val Asn Gln Met 
            340                 345                 350         


Ile Asn Glu Ala Lys Lys Gln Leu Leu Glu Phe Asp Thr Gln Ser Lys 
        355                 360                 365             


Asn Ile Leu Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
    370                 375                 380                 


Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys Val Phe Ser Thr 
385                 390                 395                 400 


Pro Ile Pro Phe Ser Tyr Ser Lys Asn Leu Asp Cys Trp Val Asp Asn 
                405                 410                 415     


Glu Glu Asp Ile Asp Val Ile Leu Lys Lys Ser Thr Ile Leu Asn Leu 
            420                 425                 430         


Asp Ile Asn Asn Asp Ile Ile Ser Asp Ile Ser Gly Phe Asn Ser Ser 
        435                 440                 445             


Val Ile Thr Tyr Pro Asp Ala Gln Leu Val Pro Gly Ile Asn Gly Lys 
    450                 455                 460                 


Ala Ile His Leu Val Asn Asn Glu Ser Ser Glu Val Ile Val His Lys 
465                 470                 475                 480 


Ala Met Asp Ile Glu Tyr Asn Asp Met Phe Asn Asn Phe Thr Val Ser 
                485                 490                 495     


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gln Tyr 
            500                 505                 510         


Gly Thr Asn Glu Tyr Ser Ile Ile Ser Ser Met Lys Lys His Ser Leu 
        515                 520                 525             


Ser Ile Gly Ser Gly Trp Ser Val Ser Leu Lys Gly Asn Asn Leu Ile 
    530                 535                 540                 


Trp Thr Leu Lys Asp Ser Ala Gly Glu Val Arg Gln Ile Thr Phe Arg 
545                 550                 555                 560 


Asp Leu Pro Asp Lys Phe Asn Ala Tyr Leu Ala Asn Lys Trp Val Phe 
                565                 570                 575     


Ile Thr Ile Thr Asn Asp Arg Leu Ser Ser Ala Asn Leu Tyr Ile Asn 
            580                 585                 590         


Gly Val Leu Met Gly Ser Ala Glu Ile Thr Gly Leu Gly Ala Ile Arg 
        595                 600                 605             


Glu Asp Asn Asn Ile Thr Leu Lys Leu Asp Arg Cys Asn Asn Asn Asn 
    610                 615                 620                 


Gln Tyr Val Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala Leu Asn 
625                 630                 635                 640 


Pro Lys Glu Ile Glu Lys Leu Tyr Thr Ser Tyr Leu Ser Ile Thr Phe 
                645                 650                 655     


Leu Arg Asp Phe Trp Gly Asn Pro Leu Arg Tyr Asp Thr Glu Tyr Tyr 
            660                 665                 670         


Leu Ile Pro Val Ala Ser Ser Ser Lys Asp Val Gln Leu Lys Asn Ile 
        675                 680                 685             


Thr Asp Tyr Met Tyr Leu Thr Asn Ala Pro Ser Tyr Thr Asn Gly Lys 
    690                 695                 700                 


Leu Asn Ile Tyr Tyr Arg Arg Leu Tyr Asn Gly Leu Lys Phe Ile Ile 
705                 710                 715                 720 


Lys Arg Tyr Thr Pro Asn Asn Glu Ile Asp Ser Phe Val Lys Ser Gly 
                725                 730                 735     


Asp Phe Ile Lys Leu Tyr Val Ser Tyr Asn Asn Asn Glu His Ile Val 
            740                 745                 750         


Gly Tyr Pro Lys Asp Gly Asn Ala Phe Asn Asn Leu Asp Arg Ile Leu 
        755                 760                 765             


Arg Val Gly Tyr Asn Ala Pro Gly Ile Pro Leu Tyr Lys Lys Met Glu 
    770                 775                 780                 


Ala Val Lys Leu Arg Asp Leu Lys Thr Tyr Ser Val Gln Leu Lys Leu 
785                 790                 795                 800 


Tyr Asp Asp Lys Asn Ala Ser Leu Gly Leu Val Gly Thr His Asn Gly 
                805                 810                 815     


Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu Ile Ala Ser Asn Trp 
            820                 825                 830         


Tyr Phe Asn His Leu Lys Asp Lys Ile Leu Gly Cys Asp Trp Tyr Phe 
        835                 840                 845             


Val Pro Thr Asp Glu Gly Trp Thr Asn Asp 
    850                 855             


<210>  23
<211>  8
<212>  PRT
<213>  Clostridium tetani

<400>  23

Gly Ile Thr Glu Leu Lys Lys Leu 
1               5               


<210>  24
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  25
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  26
<211>  1314
<212>  PRT
<213>  Clostridium tetani

<400>  26

Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val Asn Asn Asp 
1               5                   10                  15      


Thr Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu Asp Ile Tyr 
            20                  25                  30          


Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Val Pro Glu Arg 
        35                  40                  45              


Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn Pro Pro Ser Ser Leu 
    50                  55                  60                  


Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro Asn Tyr Leu Arg Thr Asp 
65                  70                  75                  80  


Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu Phe Asn Arg 
                85                  90                  95      


Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu Asp Lys Ile Ile Asn 
            100                 105                 110         


Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser Leu Leu Asp Lys Phe Asp 
        115                 120                 125             


Thr Asn Ser Asn Ser Val Ser Phe Asn Leu Leu Glu Gln Asp Pro Ser 
    130                 135                 140                 


Gly Ala Thr Thr Lys Ser Ala Met Leu Thr Asn Leu Ile Ile Phe Gly 
145                 150                 155                 160 


Pro Gly Pro Val Leu Asn Lys Asn Glu Val Arg Gly Ile Val Leu Arg 
                165                 170                 175     


Val Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe Gly Ser Ile 
            180                 185                 190         


Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro Thr Phe Asp Asn Val 
        195                 200                 205             


Ile Glu Asn Ile Thr Ser Leu Thr Ile Gly Lys Ser Lys Tyr Phe Gln 
    210                 215                 220                 


Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His Gly 
225                 230                 235                 240 


Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile Pro Ser Lys Gln 
                245                 250                 255     


Glu Ile Tyr Met Gln His Thr Tyr Pro Ile Ser Ala Glu Glu Leu Phe 
            260                 265                 270         


Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys Asn 
        275                 280                 285             


Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys 
    290                 295                 300                 


Leu Ser Gln Val Thr Ser Cys Asn Asp Pro Asn Ile Asp Ile Asp Ser 
305                 310                 315                 320 


Tyr Lys Gln Ile Tyr Gln Gln Lys Tyr Gln Phe Asp Lys Asp Ser Asn 
                325                 330                 335     


Gly Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln Ile Leu Tyr Asn Ser 
            340                 345                 350         


Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly Lys Lys Phe Asn Ile 
        355                 360                 365             


Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His Asp Pro Val Lys Ile 
    370                 375                 380                 


Pro Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp Thr Glu Gly Phe Asn 
385                 390                 395                 400 


Ile Glu Ser Lys Asp Leu Lys Ser Glu Tyr Lys Gly Gln Asn Met Arg 
                405                 410                 415     


Val Asn Thr Asn Ala Phe Arg Asn Val Asp Gly Ser Gly Leu Val Ser 
            420                 425                 430         


Lys Leu Ile Gly Leu Cys Lys Lys Ile Ile Pro Pro Thr Asn Ile Arg 
        435                 440                 445             


Glu Asn Leu Tyr Asn Arg Thr Ala Ser Leu Thr Asp Leu Gly Gly Glu 
    450                 455                 460                 


Leu Cys Ile Lys Ile Lys Asn Glu Asp Leu Thr Phe Ile Ala Glu Lys 
465                 470                 475                 480 


Asn Ser Phe Ser Glu Glu Pro Phe Gln Asp Glu Ile Val Ser Tyr Asn 
                485                 490                 495     


Thr Lys Asn Lys Pro Leu Asn Phe Asn Tyr Ser Leu Asp Lys Ile Ile 
            500                 505                 510         


Val Asp Tyr Asn Leu Gln Ser Lys Ile Thr Leu Pro Asn Asp Arg Thr 
        515                 520                 525             


Thr Pro Val Thr Lys Gly Ile Pro Tyr Ala Pro Glu Tyr Lys Ser Asn 
    530                 535                 540                 


Ala Ala Ser Thr Ile Glu Ile His Asn Ile Asp Asp Asn Thr Ile Tyr 
545                 550                 555                 560 


Gln Tyr Leu Tyr Ala Gln Lys Ser Pro Thr Thr Leu Gln Arg Ile Thr 
                565                 570                 575     


Met Thr Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile Tyr 
            580                 585                 590         


Ser Tyr Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala Gln Gly 
        595                 600                 605             


Ile Leu Phe Leu Gln Trp Val Arg Asp Ile Ile Asp Asp Phe Thr Asn 
    610                 615                 620                 


Glu Ser Ser Gln Lys Thr Thr Ile Asp Lys Ile Ser Asp Val Ser Thr 
625                 630                 635                 640 


Ile Val Pro Tyr Ile Gly Pro Ala Leu Asn Ile Val Lys Gln Gly Tyr 
                645                 650                 655     


Glu Gly Asn Phe Ile Gly Ala Leu Glu Thr Thr Gly Val Val Leu Leu 
            660                 665                 670         


Leu Glu Tyr Ile Pro Glu Ile Thr Leu Pro Val Ile Ala Ala Leu Ser 
        675                 680                 685             


Ile Ala Glu Ser Ser Thr Gln Lys Glu Lys Ile Ile Lys Thr Ile Asp 
    690                 695                 700                 


Asn Phe Leu Glu Lys Arg Tyr Glu Lys Trp Ile Glu Val Tyr Lys Leu 
705                 710                 715                 720 


Val Lys Ala Lys Trp Leu Gly Thr Val Asn Thr Gln Phe Gln Lys Arg 
                725                 730                 735     


Ser Tyr Gln Met Tyr Arg Ser Leu Glu Tyr Gln Val Asp Ala Ile Lys 
            740                 745                 750         


Lys Ile Ile Asp Tyr Glu Tyr Lys Ile Tyr Ser Gly Pro Asp Lys Glu 
        755                 760                 765             


Gln Ile Ala Asp Glu Ile Asn Asn Leu Lys Asn Lys Leu Glu Glu Lys 
    770                 775                 780                 


Ala Asn Lys Ala Met Ile Asn Ile Asn Ile Phe Met Arg Glu Ser Ser 
785                 790                 795                 800 


Arg Ser Phe Leu Val Asn Gln Met Ile Asn Glu Ala Lys Lys Gln Leu 
                805                 810                 815     


Leu Glu Phe Asp Thr Gln Ser Lys Asn Ile Leu Met Gln Tyr Ile Lys 
            820                 825                 830         


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
        835                 840                 845             


Lys Ile Asn Lys Val Phe Ser Thr Pro Ile Pro Phe Ser Tyr Ser Lys 
    850                 855                 860                 


Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile Leu 
865                 870                 875                 880 


Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile Ser 
                885                 890                 895     


Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala Gln 
            900                 905                 910         


Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn Glu 
        915                 920                 925             


Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn Asp 
    930                 935                 940                 


Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
945                 950                 955                 960 


Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile Ile 
                965                 970                 975     


Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser Val 
            980                 985                 990         


Ser Leu Lys Gly Asn Asn Leu Ile  Trp Thr Leu Lys Asp  Ser Ala Gly 
        995                 1000                 1005             


Glu Val  Arg Gln Ile Thr Phe  Arg Asp Leu Pro Asp  Lys Phe Asn 
    1010                 1015                 1020             


Ala Tyr  Leu Ala Asn Lys Trp  Val Phe Ile Thr Ile  Thr Asn Asp 
    1025                 1030                 1035             


Arg Leu  Ser Ser Ala Asn Leu  Tyr Ile Asn Gly Val  Leu Met Gly 
    1040                 1045                 1050             


Ser Ala  Glu Ile Thr Gly Leu  Gly Ala Ile Arg Glu  Asp Asn Asn 
    1055                 1060                 1065             


Ile Thr  Leu Lys Leu Asp Arg  Cys Asn Asn Asn Asn  Gln Tyr Val 
    1070                 1075                 1080             


Ser Ile  Asp Lys Phe Arg Ile  Phe Cys Lys Ala Leu  Asn Pro Lys 
    1085                 1090                 1095             


Glu Ile  Glu Lys Leu Tyr Thr  Ser Tyr Leu Ser Ile  Thr Phe Leu 
    1100                 1105                 1110             


Arg Asp  Phe Trp Gly Asn Pro  Leu Arg Tyr Asp Thr  Glu Tyr Tyr 
    1115                 1120                 1125             


Leu Ile  Pro Val Ala Ser Ser  Ser Lys Asp Val Gln  Leu Lys Asn 
    1130                 1135                 1140             


Ile Thr  Asp Tyr Met Tyr Leu  Thr Asn Ala Pro Ser  Tyr Thr Asn 
    1145                 1150                 1155             


Gly Lys  Leu Asn Ile Tyr Tyr  Arg Arg Leu Tyr Asn  Gly Leu Lys 
    1160                 1165                 1170             


Phe Ile  Ile Lys Arg Tyr Thr  Pro Asn Asn Glu Ile  Asp Ser Phe 
    1175                 1180                 1185             


Val Lys  Ser Gly Asp Phe Ile  Lys Leu Tyr Val Ser  Tyr Asn Asn 
    1190                 1195                 1200             


Asn Glu  His Ile Val Gly Tyr  Pro Lys Asp Gly Asn  Ala Phe Asn 
    1205                 1210                 1215             


Asn Leu  Asp Arg Ile Leu Arg  Val Gly Tyr Asn Ala  Pro Gly Ile 
    1220                 1225                 1230             


Pro Leu  Tyr Lys Lys Met Glu  Ala Val Lys Leu Arg  Asp Leu Lys 
    1235                 1240                 1245             


Thr Tyr  Ser Val Gln Leu Lys  Leu Tyr Asp Asp Lys  Asn Ala Ser 
    1250                 1255                 1260             


Leu Gly  Leu Val Gly Thr His  Asn Gly Gln Ile Gly  Asn Asp Pro 
    1265                 1270                 1275             


Asn Arg  Asp Ile Leu Ile Ala  Ser Asn Trp Tyr Phe  Asn His Leu 
    1280                 1285                 1290             


Lys Asp  Lys Ile Leu Gly Cys  Asp Trp Tyr Phe Val  Pro Thr Asp 
    1295                 1300                 1305             


Glu Gly  Trp Thr Asn Asp 
    1310                 


<210>  27
<211>  456
<212>  PRT
<213>  Clostridium tetani

<400>  27

Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val Asn Asn Asp 
1               5                   10                  15      


Thr Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu Asp Ile Tyr 
            20                  25                  30          


Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Val Pro Glu Arg 
        35                  40                  45              


Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn Pro Pro Ser Ser Leu 
    50                  55                  60                  


Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro Asn Tyr Leu Arg Thr Asp 
65                  70                  75                  80  


Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu Phe Asn Arg 
                85                  90                  95      


Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu Asp Lys Ile Ile Asn 
            100                 105                 110         


Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser Leu Leu Asp Lys Phe Asp 
        115                 120                 125             


Thr Asn Ser Asn Ser Val Ser Phe Asn Leu Leu Glu Gln Asp Pro Ser 
    130                 135                 140                 


Gly Ala Thr Thr Lys Ser Ala Met Leu Thr Asn Leu Ile Ile Phe Gly 
145                 150                 155                 160 


Pro Gly Pro Val Leu Asn Lys Asn Glu Val Arg Gly Ile Val Leu Arg 
                165                 170                 175     


Val Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe Gly Ser Ile 
            180                 185                 190         


Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro Thr Phe Asp Asn Val 
        195                 200                 205             


Ile Glu Asn Ile Thr Ser Leu Thr Ile Gly Lys Ser Lys Tyr Phe Gln 
    210                 215                 220                 


Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His Gly 
225                 230                 235                 240 


Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile Pro Ser Lys Gln 
                245                 250                 255     


Glu Ile Tyr Met Gln His Thr Tyr Pro Ile Ser Ala Glu Glu Leu Phe 
            260                 265                 270         


Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys Asn 
        275                 280                 285             


Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys 
    290                 295                 300                 


Leu Ser Gln Val Thr Ser Cys Asn Asp Pro Asn Ile Asp Ile Asp Ser 
305                 310                 315                 320 


Tyr Lys Gln Ile Tyr Gln Gln Lys Tyr Gln Phe Asp Lys Asp Ser Asn 
                325                 330                 335     


Gly Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln Ile Leu Tyr Asn Ser 
            340                 345                 350         


Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly Lys Lys Phe Asn Ile 
        355                 360                 365             


Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His Asp Pro Val Lys Ile 
    370                 375                 380                 


Pro Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp Thr Glu Gly Phe Asn 
385                 390                 395                 400 


Ile Glu Ser Lys Asp Leu Lys Ser Glu Tyr Lys Gly Gln Asn Met Arg 
                405                 410                 415     


Val Asn Thr Asn Ala Phe Arg Asn Val Asp Gly Ser Gly Leu Val Ser 
            420                 425                 430         


Lys Leu Ile Gly Leu Cys Lys Lys Ile Ile Pro Pro Thr Asn Ile Arg 
        435                 440                 445             


Glu Asn Leu Tyr Asn Arg Thr Ala 
    450                 455     


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer Sequence

<400>  28

Ala Ala Lys Tyr Ala Arg Val Arg Ala Lys 
1               5                   10  


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate I Spacer Sequence

<400>  29

Gln Gln Gln Pro Pro Pro 
1               5       


<210>  30
<211>  12
<212>  PRT
<213>  Clostridium tetani

<400>  30

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Clostridium tetani

<400>  31

Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10          


<210>  32
<211>  14
<212>  PRT
<213>  Clostridium tetani

<400>  32

Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
1               5                   10                  


<210>  33
<211>  14
<212>  PRT
<213>  Clostridium tetani

<400>  33

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  34
<211>  16
<212>  PRT
<213>  Clostridium tetani

<400>  34

Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
1               5                   10                  15      


<210>  35
<211>  16
<212>  PRT
<213>  Clostridium tetani

<400>  35

Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  15      


<210>  36
<211>  18
<212>  PRT
<213>  Clostridium tetani

<400>  36

Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu 
1               5                   10                  15      


Glu Ser 
        


<210>  37
<211>  18
<212>  PRT
<213>  Clostridium tetani

<400>  37

Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
1               5                   10                  15      


Lys Ile 
        


<210>  38
<211>  20
<212>  PRT
<213>  Clostridium tetani

<400>  38

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys 
1               5                   10                  15      


Lys Leu Glu Ser 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Clostridium tetani

<400>  39

Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu 
1               5                   10                  15      


Glu Ser Lys Ile 
            20  


<210>  40
<211>  22
<212>  PRT
<213>  Clostridium tetani

<400>  40

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys 
1               5                   10                  15      


Lys Leu Glu Ser Lys Ile 
            20          


<210>  41
<211>  20
<212>  PRT
<213>  Clostridium tetani

<400>  41

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ser Thr 
            20  


<210>  42
<211>  19
<212>  PRT
<213>  Clostridium tetani

<400>  42

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ser 
            


<210>  43
<211>  18
<212>  PRT
<213>  Clostridium tetani

<400>  43

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  44
<211>  17
<212>  PRT
<213>  Clostridium tetani

<400>  44

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val 
    


<210>  45
<211>  16
<212>  PRT
<213>  Clostridium tetani

<400>  45

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


<210>  46
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  46

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn 
1               5                   10                  15  


<210>  47
<211>  14
<212>  PRT
<213>  Clostridium tetani

<400>  47

Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Clostridium tetani

<400>  48

Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  


<210>  49
<211>  14
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  FORMYLATION

<400>  49

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  50
<211>  14
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  FORMYLATION

<400>  50

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  51
<211>  14
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  FORMYLATION

<400>  51

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  52
<211>  14
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  MOD_RES
<222>  (8)..(9)
<223>  FORMYLATION

<400>  52

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  53
<211>  14
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  FORMYLATION

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  FORMYLATION

<400>  53

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  54

Ala Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  55

Phe Ala Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  56
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  56

Phe Ile Ala Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  57

Phe Ile Gly Ile Thr Ala Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  58

Phe Ile Gly Ile Thr Glu Ala Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  59

Phe Ile Gly Ile Thr Glu Leu Ala Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  60

Phe Ile Gly Ile Thr Glu Leu Lys Ala Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  61
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  61

Phe Ile Gly Ile Thr Glu Leu Lys Lys Ala Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  62
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  62

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Ala Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  63
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  63

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ala Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  64
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  64

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Ala Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  65

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ala Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  66

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Ala Lys 
1               5                   10                  15      


Val Phe 
        


<210>  67
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  67

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Ala 
1               5                   10                  15      


Val Phe 
        


<210>  68
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  68

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Ala Phe 
        


<210>  69
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  69

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Ala 
        


<210>  70
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  70

Tyr Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  71
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  71

Phe Leu Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  72
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  72

Phe Ile Ser Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  73
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  73

Phe Ile Gly Leu Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  74
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  74

Phe Ile Gly Ile Ser Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  75
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  75

Phe Ile Gly Ile Thr Asp Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  76
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  76

Phe Ile Gly Ile Thr Glu Ile Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  77

Phe Ile Gly Ile Thr Glu Leu Arg Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  78
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  78

Phe Ile Gly Ile Thr Glu Leu Lys Arg Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  79
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  79

Phe Ile Gly Ile Thr Glu Leu Lys Lys Ile Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  80
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  80

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Thr Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  81
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  81

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Arg Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  82
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  82

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Leu Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  83
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  83

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Gln Lys 
1               5                   10                  15      


Val Phe 
        


<210>  84
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  84

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Arg 
1               5                   10                  15      


Val Phe 
        


<210>  85
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  85

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Leu Phe 
        


<210>  86
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified MTTE

<400>  86

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Tyr 
        


<210>  87
<211>  19
<212>  PRT
<213>  Gallus gallus

<400>  87

Leu Glu Gln Leu Glu Ser Ile Ile Asn Phe Glu Lys Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Lys 
            


<210>  88
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scrambled SLP

<400>  88

Asp Gly Leu Gln Gly Leu Leu Leu Gly Leu Arg Gln Arg Ile Glu Thr 
1               5                   10                  15      


Leu Glu Gly Lys 
            20  


<210>  89
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  89

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  90
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  90

Ile Leu Leu Trp Gln Pro Ile Pro Val 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  91

Tyr Leu Pro Phe Arg Asn Cys Pro Arg 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  92

Leu Tyr Cys Glu Ser Val His Asn Phe 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Met Asn Asp Gln Leu Met Phe Leu 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  94

Val Leu Ala Gly Gly Phe Phe Leu Leu 
1               5                   


<210>  95
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  95

Leu Leu Ala Val Thr Ser Ile Pro Ser Val 
1               5                   10  


<210>  96
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  96

Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu Leu Ser 
1               5                   10                  15  


<210>  97
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  97

Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu 
1               5                   10  


<210>  98
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scrambled MTTE

<400>  98

Glu Lys Leu Ile Asn Lys Leu Ser Lys Ile Phe Lys Gly Thr Ile Glu 
1               5                   10                  15      


Val Phe 
        


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer Sequence

<400>  99

Ala Glu Lys Tyr Ala Arg Val Arg Ala Lys 
1               5                   10  


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B Cell Epitope Containing Peptide

<400>  100

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ala Glu Lys Tyr Ala Arg Val Arg Ala Lys Cys 
            20                  25                  


<210>  101
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  101

Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu 
1               5                   10                  15  


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer Sequence

<400>  102

Ala Ala Lys Tyr Ala Arg Val Arg Ala Lys Cys 
1               5                   10      


<210>  103
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scrambled MTTE with Spacer

<400>  103

Glu Lys Leu Ile Asn Lys Leu Ser Lys Ile Phe Lys Gly Thr Ile Glu 
1               5                   10                  15      


Val Phe Ser Ser Ala Phe Ala Asp Val Glu Ala Ala 
            20                  25              


<210>  104
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTTE with Spacer

<400>  104

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ser Ser Ala Phe Ala Asp Val Glu Ala Ala 
            20                  25              


<210>  105
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTTE with Spacer

<400>  105

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ala Ala Lys Tyr Ala Arg Val Arg Ala 
            20                  25          


<210>  106
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate I SLP without TAP Sequence

<400>  106

Asn Tyr Ala Arg Thr Glu Asp Phe Phe Gln Gln Gln Pro Pro Pro Gly 
1               5                   10                  15      


Gln Asp Leu Phe Gly Ile Trp Ser Lys Val Tyr Asp Pro Leu 
            20                  25                  30  


<210>  107
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate II SLP without TAP Sequence

<400>  107

Leu Leu His Glu Thr Asp Ser Ala Val Ala Ala Ala Arg Gln Ile Tyr 
1               5                   10                  15      


Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu 
            20                  25          


<210>  108
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate III SLP without TAP Sequence

<400>  108

Ser Leu Ser Leu Gly Phe Leu Phe Leu Ala Ala Ala Gly Lys Val Phe 
1               5                   10                  15      


Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala 
            20                  25          


<210>  109
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate IV SLP without TAP Sequence

<400>  109

Gly Met Pro Glu Gly Asp Leu Val Tyr Thr Gly Asn Phe Ser Thr Gln 
1               5                   10                  15      


Lys Val Lys Met His Ile His Ser 
            20                  


<210>  110
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate V SLP without TAP Sequence

<400>  110

Lys Val Phe Arg Gly Asn Lys Val Lys Asn Tyr Thr Leu Arg Val Asp 
1               5                   10                  15      


Cys Thr Pro Leu Met Tyr Ser Leu 
            20                  


