               SEQUENCE LISTING

<110> Rijk Zwaan Zaadteelt en Zaadhandel B.V.

<120> CCA GENE FOR VIRUS RESISTANCE

<130> L/P167106PC01/JGE

<140> EPPCT/2019/083733
<141> 2019-12-04

<160> 19

<170> BiSSAP 1.3.6

<210> 1
<211> 1770
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> CCA1 cDNA|Sl3_00 Solanum lycopersicum (S) wildtype

<400> 1
atgaaggctt tgagtatagc cgtagcagca ttttcaacat tccatacaac tcgccctcgt      60

ctcttcactt tcccaaaccc ttctacttct tcttctctcc ttcttccgtc cttcaaacta     120

aagagatttt ctatcttctc cattcaacaa ccgccgccgg cgttagggtt ttacgccgga     180

gttacaacaa tggtggaggg ctcagcattt cagccgttgt cagttcaagt gaaggaccat     240

attgatttat cgccaaaaga ggagcagata ttcaaccgtc ttcttcaagt tgtcgagcat     300

tataatatgg gaacacagct tcgtgttgct ggtggttggg ttcgcgataa gctgctaggt     360

aaagagtgct atgatattga tattgctctt gacaacatgt atggacgaga attctgtgag     420

aaagtgaacg agtacttgtc agcatcaggt gaggaaaccc aaggagttgg tgttatccag     480

tgcaatcccg atcagtcaaa acacttggaa acagcgagga tgcgcctttt cgacgtatgg     540

attgattttg tcaacttaag agcagaagac tacagtgaga acagtcgaat tccaacaatg     600

aaatttggga ctgcaaaaca ggatgctgat cgcagggatt taaccattaa tagcttgttt     660

tacaacatta acaccagatc agtcgaagat cttacagaaa gaggcattgc agatctgaag     720

tctggaaaaa ttgtcactcc actacctcca aagcagacct ttttggatga tcccctaaga     780

gttcttcgag ctattcgttt tggtgcaagg tttgggttta tattagatga agaactaaag     840

aaggcagctg cagatgaaga cgtgagagtt gctattgctg ataaaattag cagagaacgc     900

ataggacatg aaattgatct tatgatgtct ggtgaccaac cggtcaaagc aatgacttat     960

attgctgact tgaagttatt ttcggctgta tttagtcttc cttctgattt tgagccatca    1020

attcctgatg gatgtgatag gctgtgtgtt acttgcttgg gttcagcttg ggaactttta    1080

aaccttattg gacgctcctc attttcagat gatcagagga gactttgcct gtatgctgct    1140

ttatttttgc cattcagaga gaccatttat agagataaca aagccaaaaa gattccagtt    1200

gtcaattata tttttcgcaa ttctctcaag ttgaaggcca gtgatgcgga aatagtcatg    1260

agcttgcata cggtaactag gaaatttgtc accttaatat cactactcat ttctaaagac    1320

gatatccaag ttcttgaagt tgattggaaa agggatacca ttgaggttcc aatagcttca    1380

aaacttagaa tattgactgg tttgctactt cgagaaatta aagaattttg gcgtgtcgct    1440

cttcttctat ctatgctgct acatcctgtt gacgttgtgt cctctacaag tttctcaaat    1500

gagaactttg aactggacaa gagtagcgga ttatttaaga cagtagagaa tgcagtaaga    1560

acactaggtc tggagaaggt ttgggaaatg aaaccactgg ttaatggaaa ggaaattatg    1620

aatattttgg agattaaaag tggagggcca gttgttagag aatggcaaca aaaactgctg    1680

gagtggcagc tcgcacaccc ttctggttca gctgaagaat gcatcgactg gatgaagcaa    1740

gcacagtcaa aacgtgcaag aaccgagtag                                     1770


<210> 2
<211> 589
<212> PRT
<213> Solanum lycopersicum


<220> 
<223> CCA1 protein|Wildtype CCA-adding enzyme

<400> 2
Met Lys Ala Leu Ser Ile Ala Val Ala Ala Phe Ser Thr Phe His Thr 
1               5                   10                  15      
Thr Arg Pro Arg Leu Phe Thr Phe Pro Asn Pro Ser Thr Ser Ser Ser 
            20                  25                  30          
Leu Leu Leu Pro Ser Phe Lys Leu Lys Arg Phe Ser Ile Phe Ser Ile 
        35                  40                  45              
Gln Gln Pro Pro Pro Ala Leu Gly Phe Tyr Ala Gly Val Thr Thr Met 
    50                  55                  60                  
Val Glu Gly Ser Ala Phe Gln Pro Leu Ser Val Gln Val Lys Asp His 
65                  70                  75                  80  
Ile Asp Leu Ser Pro Lys Glu Glu Gln Ile Phe Asn Arg Leu Leu Gln 
                85                  90                  95      
Val Val Glu His Tyr Asn Met Gly Thr Gln Leu Arg Val Ala Gly Gly 
            100                 105                 110         
Trp Val Arg Asp Lys Leu Leu Gly Lys Glu Cys Tyr Asp Ile Asp Ile 
        115                 120                 125             
Ala Leu Asp Asn Met Tyr Gly Arg Glu Phe Cys Glu Lys Val Asn Glu 
    130                 135                 140                 
Tyr Leu Ser Ala Ser Gly Glu Glu Thr Gln Gly Val Gly Val Ile Gln 
145                 150                 155                 160 
Cys Asn Pro Asp Gln Ser Lys His Leu Glu Thr Ala Arg Met Arg Leu 
                165                 170                 175     
Phe Asp Val Trp Ile Asp Phe Val Asn Leu Arg Ala Glu Asp Tyr Ser 
            180                 185                 190         
Glu Asn Ser Arg Ile Pro Thr Met Lys Phe Gly Thr Ala Lys Gln Asp 
        195                 200                 205             
Ala Asp Arg Arg Asp Leu Thr Ile Asn Ser Leu Phe Tyr Asn Ile Asn 
    210                 215                 220                 
Thr Arg Ser Val Glu Asp Leu Thr Glu Arg Gly Ile Ala Asp Leu Lys 
225                 230                 235                 240 
Ser Gly Lys Ile Val Thr Pro Leu Pro Pro Lys Gln Thr Phe Leu Asp 
                245                 250                 255     
Asp Pro Leu Arg Val Leu Arg Ala Ile Arg Phe Gly Ala Arg Phe Gly 
            260                 265                 270         
Phe Ile Leu Asp Glu Glu Leu Lys Lys Ala Ala Ala Asp Glu Asp Val 
        275                 280                 285             
Arg Val Ala Ile Ala Asp Lys Ile Ser Arg Glu Arg Ile Gly His Glu 
    290                 295                 300                 
Ile Asp Leu Met Met Ser Gly Asp Gln Pro Val Lys Ala Met Thr Tyr 
305                 310                 315                 320 
Ile Ala Asp Leu Lys Leu Phe Ser Ala Val Phe Ser Leu Pro Ser Asp 
                325                 330                 335     
Phe Glu Pro Ser Ile Pro Asp Gly Cys Asp Arg Leu Cys Val Thr Cys 
            340                 345                 350         
Leu Gly Ser Ala Trp Glu Leu Leu Asn Leu Ile Gly Arg Ser Ser Phe 
        355                 360                 365             
Ser Asp Asp Gln Arg Arg Leu Cys Leu Tyr Ala Ala Leu Phe Leu Pro 
    370                 375                 380                 
Phe Arg Glu Thr Ile Tyr Arg Asp Asn Lys Ala Lys Lys Ile Pro Val 
385                 390                 395                 400 
Val Asn Tyr Ile Phe Arg Asn Ser Leu Lys Leu Lys Ala Ser Asp Ala 
                405                 410                 415     
Glu Ile Val Met Ser Leu His Thr Val Thr Arg Lys Phe Val Thr Leu 
            420                 425                 430         
Ile Ser Leu Leu Ile Ser Lys Asp Asp Ile Gln Val Leu Glu Val Asp 
        435                 440                 445             
Trp Lys Arg Asp Thr Ile Glu Val Pro Ile Ala Ser Lys Leu Arg Ile 
    450                 455                 460                 
Leu Thr Gly Leu Leu Leu Arg Glu Ile Lys Glu Phe Trp Arg Val Ala 
465                 470                 475                 480 
Leu Leu Leu Ser Met Leu Leu His Pro Val Asp Val Val Ser Ser Thr 
                485                 490                 495     
Ser Phe Ser Asn Glu Asn Phe Glu Leu Asp Lys Ser Ser Gly Leu Phe 
            500                 505                 510         
Lys Thr Val Glu Asn Ala Val Arg Thr Leu Gly Leu Glu Lys Val Trp 
        515                 520                 525             
Glu Met Lys Pro Leu Val Asn Gly Lys Glu Ile Met Asn Ile Leu Glu 
    530                 535                 540                 
Ile Lys Ser Gly Gly Pro Val Val Arg Glu Trp Gln Gln Lys Leu Leu 
545                 550                 555                 560 
Glu Trp Gln Leu Ala His Pro Ser Gly Ser Ala Glu Glu Cys Ile Asp 
                565                 570                 575     
Trp Met Lys Gln Ala Gln Ser Lys Arg Ala Arg Thr Glu 
            580                 585                 

<210> 3
<211> 1001
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> Promoter of the wildtype CCA1 gene

<400> 3
atatactata tctatatata ttactttggt gtgttaaaag agtgagaatg agatattaca      60

tcaaaataat ttttcttcct tatttatttg tttggtttct taagtaaaat atatattttt     120

tgttaaattc tgatttctag ttatagtaca agaaaaactt gttgaataca cctttatcgg     180

tgaaatatcc ttaaggacag tgatttaggt atgcctcaag ttacgtgatt tccaatagtt     240

ttacaacaat aataatacaa atataaatca ttctttccat tttttttgtc tttctttctc     300

tcactttata caaacacaaa ttgtgtaaaa aattatacaa aatttgtgtt tgtataaaac     360

gagagagaga tttcatatac aaatatttta acttgattca attgtatacg agtttaaagt     420

ttatgcagat atacaaactg aatcattcat aaatatacat agtagttaga tatatacaat     480

tatctaattg atatacatat acaattcacc tctctcccct ctctatccca ctctagctcg     540

cctctctcat ctctctctct caatcttgct cgtcgctcta acctaacaca gagaacatat     600

acatatacaa acacaatatt catagacaca gacgaatgag cgctcgatta atataaattg     660

gcgcgattta tacaaattag atgctccata acaaacataa tctgattatg aagcataaat     720

aacaaaatta tagctgagaa ctctaatata aatttttttt tatctttgat acacctaaaa     780

tttactcaat aaaatgtgac tatatttatt ctaagctaat tacattattg tacttattca     840

tgttttaact ttaactattt ttattttttt ttaaatattt attttttttt aaataaaaaa     900

ataaacttgc cacatcatga aagatgtagt tgggatgacc cgacccgttt tctatgctta     960

tgagagcggg tcatcacttg tccgttagaa agagagaaga a                        1001


<210> 4
<211> 10
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> Deletion in the promoter sequence

<400> 4
atatttattt                                                           10


<210> 5
<211> 1101
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> CCA2 cDNA|Sl3_00 Solanum lycopersicum (S) wildtype

<400> 5
atgaaggctt tgagtatagc cgtagcagca ttttcaacat tccatacaac tcgccctcgt      60

ctcttcactt tcccaaaccc ttctacttct tcttctctcc ttcttccgtc cttcaaacta     120

aagagatttt ctatcttctc cgttcaacaa acgccgccgg cgttagggtt ttacgccgga     180

gttacaacaa tggtggaggg ctcagcattt cagccgttgt cagttcaagt gaaggaccat     240

attgatttat cgccgaaaga ggagcagata ttcaaccgtc ttcttcaagt tgtcgagcat     300

tataatatgg gaacacagct tcgtgttgct ggtggttggg ttcgcgataa gctgctaggt     360

aaagagtgct atgatattga tattgctctt gacaacatgt atggacgaga attctgtgag     420

aaagtgaacg agtacttgtc agcatcaggt gaggaaaccc aaggagttgg tgttatccaa     480

tgcaatcctg atcagtcaaa acacttggaa acagcaagga tgcgcctttc cgacgtatgg     540

attgattttg tcaacttaag agcagaagac tacagtgaga acagtcgaat tccaacaatg     600

aaatttggca ctgcaaaaca ggatgctgat tgcagggatt taaccatcaa tagcttgttt     660

tacaacatta acaccagatc agtcgaagat cttacagaaa gaggcattgc agatctgaag     720

tctggaaaaa ttgtcactcc actacctcca aaacagacct ttttggatga tcccctaaga     780

gttcttcgag ctattcgttt tggtgcaagg tttgggttta tattagatga agaactaaag     840

aaggcagctg cagatgaaga cgtgagagtt gctattgctg ataaaattag cagagaacgc     900

ataggacatg aaattgatct tatgatgtct ggtgaccaac cggtcaaagc aatgacttat     960

attgctgact tgaagttatt ttcggctgta tttagtcttc cttctgattt tgagccatca    1020

attcctgatg gatgtgatag gctgtgtgtt tcttgcttgg gaacttttaa accttattgg    1080

acgctcctca ttttcagatg a                                              1101


<210> 6
<211> 11
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> Deletion in a CCA gene

<400> 6
ttcagcttgg g                                                         11


<210> 7
<211> 366
<212> PRT
<213> Solanum lycopersicum


<220> 
<223> CCA2 protein|Wildtype CCA-adding enzyme

<400> 7
Met Lys Ala Leu Ser Ile Ala Val Ala Ala Phe Ser Thr Phe His Thr 
1               5                   10                  15      
Thr Arg Pro Arg Leu Phe Thr Phe Pro Asn Pro Ser Thr Ser Ser Ser 
            20                  25                  30          
Leu Leu Leu Pro Ser Phe Lys Leu Lys Arg Phe Ser Ile Phe Ser Val 
        35                  40                  45              
Gln Gln Thr Pro Pro Ala Leu Gly Phe Tyr Ala Gly Val Thr Thr Met 
    50                  55                  60                  
Val Glu Gly Ser Ala Phe Gln Pro Leu Ser Val Gln Val Lys Asp His 
65                  70                  75                  80  
Ile Asp Leu Ser Pro Lys Glu Glu Gln Ile Phe Asn Arg Leu Leu Gln 
                85                  90                  95      
Val Val Glu His Tyr Asn Met Gly Thr Gln Leu Arg Val Ala Gly Gly 
            100                 105                 110         
Trp Val Arg Asp Lys Leu Leu Gly Lys Glu Cys Tyr Asp Ile Asp Ile 
        115                 120                 125             
Ala Leu Asp Asn Met Tyr Gly Arg Glu Phe Cys Glu Lys Val Asn Glu 
    130                 135                 140                 
Tyr Leu Ser Ala Ser Gly Glu Glu Thr Gln Gly Val Gly Val Ile Gln 
145                 150                 155                 160 
Cys Asn Pro Asp Gln Ser Lys His Leu Glu Thr Ala Arg Met Arg Leu 
                165                 170                 175     
Ser Asp Val Trp Ile Asp Phe Val Asn Leu Arg Ala Glu Asp Tyr Ser 
            180                 185                 190         
Glu Asn Ser Arg Ile Pro Thr Met Lys Phe Gly Thr Ala Lys Gln Asp 
        195                 200                 205             
Ala Asp Cys Arg Asp Leu Thr Ile Asn Ser Leu Phe Tyr Asn Ile Asn 
    210                 215                 220                 
Thr Arg Ser Val Glu Asp Leu Thr Glu Arg Gly Ile Ala Asp Leu Lys 
225                 230                 235                 240 
Ser Gly Lys Ile Val Thr Pro Leu Pro Pro Lys Gln Thr Phe Leu Asp 
                245                 250                 255     
Asp Pro Leu Arg Val Leu Arg Ala Ile Arg Phe Gly Ala Arg Phe Gly 
            260                 265                 270         
Phe Ile Leu Asp Glu Glu Leu Lys Lys Ala Ala Ala Asp Glu Asp Val 
        275                 280                 285             
Arg Val Ala Ile Ala Asp Lys Ile Ser Arg Glu Arg Ile Gly His Glu 
    290                 295                 300                 
Ile Asp Leu Met Met Ser Gly Asp Gln Pro Val Lys Ala Met Thr Tyr 
305                 310                 315                 320 
Ile Ala Asp Leu Lys Leu Phe Ser Ala Val Phe Ser Leu Pro Ser Asp 
                325                 330                 335     
Phe Glu Pro Ser Ile Pro Asp Gly Cys Asp Arg Leu Cys Val Ser Cys 
            340                 345                 350         
Leu Gly Thr Phe Lys Pro Tyr Trp Thr Leu Leu Ile Phe Arg 
        355                 360                 365     

<210> 8
<211> 589
<212> PRT
<213> Solanum lycopersicum


<220> 
<223> CCA1 protein|NCIMB43511, NCIMB43512

<400> 8
Met Lys Ala Leu Ser Ile Ala Val Ala Ala Phe Ser Thr Phe His Thr 
1               5                   10                  15      
Thr Arg Pro Arg Leu Phe Thr Phe Pro Asn Pro Ser Thr Ser Ser Ser 
            20                  25                  30          
Leu Leu Leu Pro Ser Phe Lys Leu Lys Arg Phe Ser Ile Phe Ser Ile 
        35                  40                  45              
Gln Gln Pro Pro Pro Ala Leu Gly Phe Tyr Ala Gly Val Thr Thr Met 
    50                  55                  60                  
Val Glu Gly Ser Ala Phe Gln Pro Leu Ser Val Gln Val Lys Asp His 
65                  70                  75                  80  
Ile Asp Leu Ser Pro Lys Glu Glu Gln Ile Phe Asn Arg Leu Leu Gln 
                85                  90                  95      
Val Val Glu His Tyr Asn Met Gly Thr Gln Leu Arg Val Ala Gly Gly 
            100                 105                 110         
Trp Val Arg Asp Lys Leu Leu Gly Lys Glu Cys Tyr Asp Ile Asp Ile 
        115                 120                 125             
Ala Leu Asp Asn Met Tyr Gly Arg Glu Phe Cys Glu Lys Val Asn Glu 
    130                 135                 140                 
Tyr Leu Ser Ala Ser Gly Glu Glu Thr Gln Gly Val Gly Val Ile Gln 
145                 150                 155                 160 
Cys Asn Pro Asp Gln Ser Lys His Leu Glu Thr Ala Arg Met Arg Leu 
                165                 170                 175     
Phe Asp Val Trp Ile Asp Phe Val Asn Leu Arg Ala Glu Asp Tyr Ser 
            180                 185                 190         
Glu Asn Ser Arg Ile Pro Thr Met Lys Phe Gly Thr Ala Lys Gln Asp 
        195                 200                 205             
Ala Asp Arg Arg Asp Leu Thr Ile Asn Ser Leu Phe Tyr Asn Ile Asn 
    210                 215                 220                 
Thr Arg Ser Val Glu Asp Leu Thr Glu Arg Gly Ile Ala Asp Leu Lys 
225                 230                 235                 240 
Ser Gly Lys Ile Val Thr Pro Leu Pro Pro Lys Gln Thr Phe Leu Asp 
                245                 250                 255     
Asp Pro Leu Arg Val Leu Arg Ala Ile Arg Phe Gly Ala Arg Phe Gly 
            260                 265                 270         
Phe Ile Leu Asp Glu Glu Leu Lys Lys Ala Ala Ala Asp Glu Asp Val 
        275                 280                 285             
Arg Val Ala Ile Ala Asp Lys Ile Ser Arg Glu Arg Ile Gly His Glu 
    290                 295                 300                 
Ile Asp Leu Met Met Ser Gly Asp Gln Pro Val Lys Ala Met Thr Tyr 
305                 310                 315                 320 
Ile Ala Asp Leu Lys Leu Phe Ser Ala Val Phe Ser Leu Pro Ser Asp 
                325                 330                 335     
Phe Glu Pro Ser Ile Pro Asp Gly Cys Asp Arg Leu Cys Val Thr Cys 
            340                 345                 350         
Leu Gly Ser Ala Trp Glu Leu Leu Asn Leu Ile Gly Arg Ser Ser Phe 
        355                 360                 365             
Ser Asp Asp Gln Arg Arg Leu Cys Leu Tyr Ala Ala Leu Phe Leu Pro 
    370                 375                 380                 
Phe Arg Glu Thr Ile Tyr Arg Asp Asn Lys Ala Lys Lys Ile Pro Val 
385                 390                 395                 400 
Val Asn Tyr Ile Phe Arg Asn Ser Leu Lys Leu Lys Ala Ser Asp Ala 
                405                 410                 415     
Glu Ile Val Met Ser Leu His Thr Val Thr Arg Lys Phe Val Thr Leu 
            420                 425                 430         
Ile Ser Leu Leu Ile Ser Lys Asp Asp Ile Gln Val Leu Glu Val Asp 
        435                 440                 445             
Trp Lys Arg Asp Thr Ile Glu Val Pro Ile Ala Ser Lys Leu Arg Ile 
    450                 455                 460                 
Leu Thr Gly Leu Leu Leu Arg Glu Ile Lys Glu Phe Trp Arg Val Ala 
465                 470                 475                 480 
Leu Leu Leu Ser Met Leu Leu His Pro Val Asp Val Val Ser Ser Thr 
                485                 490                 495     
Ser Phe Ser Asn Glu Asn Phe Glu Leu Asp Lys Ser Ser Gly Leu Phe 
            500                 505                 510         
Lys Thr Val Glu Asn Ala Val Arg Thr Leu Gly Leu Glu Lys Val Trp 
        515                 520                 525             
Glu Met Lys Pro Leu Val Asp Gly Lys Glu Ile Met Asn Ile Leu Glu 
    530                 535                 540                 
Ile Lys Ser Gly Gly Pro Val Val Ser Glu Trp Gln Gln Lys Leu Leu 
545                 550                 555                 560 
Glu Trp Gln Leu Ala His Pro Ser Gly Ser Ala Glu Glu Cys Ile Asp 
                565                 570                 575     
Trp Met Asn Gln Ala Gln Ser Lys Arg Ala Arg Thr Glu 
            580                 585                 

<210> 9
<211> 589
<212> PRT
<213> Solanum lycopersicum


<220> 
<223> CCA1 protein|TO1

<400> 9
Met Lys Ala Leu Ser Ile Ala Val Ala Ala Phe Ser Thr Phe His Thr 
1               5                   10                  15      
Thr Arg Pro Arg Leu Phe Thr Phe Pro Asn Pro Ser Thr Ser Ser Ser 
            20                  25                  30          
Leu Leu Leu Pro Ser Phe Lys Leu Lys Arg Phe Ser Ile Phe Ser Ile 
        35                  40                  45              
Gln Gln Pro Pro Pro Ala Leu Gly Phe Tyr Ala Gly Val Thr Thr Met 
    50                  55                  60                  
Val Glu Gly Ser Ala Phe Gln Pro Leu Ser Val Gln Val Lys Asp His 
65                  70                  75                  80  
Ile Asp Leu Ser Pro Lys Glu Glu Gln Ile Phe Asn Arg Leu Leu Gln 
                85                  90                  95      
Val Val Glu His Tyr Asn Met Gly Thr Gln Leu Arg Val Ala Gly Gly 
            100                 105                 110         
Trp Val Arg Asp Lys Leu Leu Gly Lys Glu Cys Tyr Asp Ile Asp Ile 
        115                 120                 125             
Ala Leu Asp Asn Met Tyr Gly Arg Glu Phe Cys Glu Lys Val Asn Glu 
    130                 135                 140                 
Tyr Leu Ser Ala Ser Gly Glu Glu Thr Gln Gly Val Gly Val Ile Gln 
145                 150                 155                 160 
Cys Asn Pro Asp Gln Ser Lys His Leu Glu Thr Ala Arg Met Arg Leu 
                165                 170                 175     
Phe Asp Val Trp Ile Asp Phe Val Asn Leu Arg Ala Glu Asp Tyr Ser 
            180                 185                 190         
Glu Asn Ser Arg Ile Pro Thr Met Lys Phe Gly Thr Ala Lys Gln Asp 
        195                 200                 205             
Ala Asp Arg Arg Asp Leu Thr Ile Asn Ser Leu Phe Tyr Asn Ile Asn 
    210                 215                 220                 
Thr Arg Ser Val Glu Asp Leu Thr Glu Arg Gly Ile Ala Asp Leu Lys 
225                 230                 235                 240 
Ser Gly Lys Ile Val Thr Pro Leu Pro Pro Lys Gln Thr Phe Leu Asp 
                245                 250                 255     
Asp Pro Leu Arg Val Leu Arg Ala Ile Arg Phe Gly Ala Arg Phe Gly 
            260                 265                 270         
Phe Ile Leu Asp Glu Glu Leu Lys Lys Ala Ala Ala Asp Glu Asp Val 
        275                 280                 285             
Arg Val Ala Ile Ala Asp Lys Ile Ser Arg Glu Arg Ile Gly His Glu 
    290                 295                 300                 
Ile Asp Leu Met Met Ser Gly Asp Gln Pro Val Lys Ala Met Thr Tyr 
305                 310                 315                 320 
Ile Ala Asp Leu Lys Leu Phe Ser Ala Val Phe Ser Leu Pro Ser Asp 
                325                 330                 335     
Phe Glu Pro Ser Ile Pro Asp Gly Cys Asp Arg Leu Cys Val Thr Cys 
            340                 345                 350         
Leu Gly Ser Ala Trp Glu Leu Leu Asn Leu Ile Gly Arg Ser Ser Phe 
        355                 360                 365             
Ser Asp Asp Gln Arg Arg Leu Cys Leu Tyr Ala Ala Leu Phe Leu Pro 
    370                 375                 380                 
Phe Arg Glu Thr Ile Tyr Arg Asp Asn Lys Ala Lys Lys Ile Pro Val 
385                 390                 395                 400 
Val Asn Tyr Ile Phe Arg Asn Ser Leu Lys Leu Lys Ala Ser Asp Ala 
                405                 410                 415     
Glu Ile Val Met Ser Leu His Thr Val Thr Arg Lys Phe Val Thr Leu 
            420                 425                 430         
Ile Ser Leu Leu Ile Ser Lys Asp Asp Ile Gln Val Leu Glu Val Asp 
        435                 440                 445             
Trp Glu Arg Asp Thr Ile Glu Val Pro Ile Ala Ser Lys Leu Arg Ile 
    450                 455                 460                 
Leu Thr Gly Leu Leu Leu Arg Glu Ile Lys Glu Phe Trp Arg Val Ala 
465                 470                 475                 480 
Leu Leu Leu Ser Met Leu Leu His Pro Val Asp Val Val Ser Ser Thr 
                485                 490                 495     
Ser Phe Ser Asn Glu Asn Phe Glu Leu Asp Lys Ser Ser Gly Leu Phe 
            500                 505                 510         
Lys Thr Val Glu Asn Ala Val Arg Thr Leu Gly Leu Glu Lys Val Trp 
        515                 520                 525             
Glu Met Lys Pro Leu Val Asn Gly Lys Glu Ile Met Asn Ile Leu Glu 
    530                 535                 540                 
Ile Lys Ser Gly Gly Pro Val Val Ser Glu Trp Gln Gln Lys Leu Leu 
545                 550                 555                 560 
Glu Trp Gln Leu Ala His Pro Ser Gly Ser Ala Glu Glu Cys Ile Asp 
                565                 570                 575     
Trp Met Asn Gln Ala Gln Ser Lys Arg Ala Arg Thr Glu 
            580                 585                 

<210> 10
<211> 366
<212> PRT
<213> Solanum lycopersicum


<220> 
<223> CCA2 protein|NCIMB43512

<400> 10
Met Lys Ala Leu Ser Ile Ala Val Ala Ala Phe Ser Thr Phe His Thr 
1               5                   10                  15      
Thr Arg Pro Arg Leu Phe Thr Phe Pro Asn Pro Ser Thr Ser Ser Ser 
            20                  25                  30          
Leu Leu Leu Pro Ser Phe Lys Leu Lys Arg Phe Ser Ile Phe Ser Val 
        35                  40                  45              
Gln Gln Thr Pro Pro Ala Leu Gly Phe Tyr Ala Gly Val Thr Thr Met 
    50                  55                  60                  
Val Glu Gly Ser Ala Phe Gln Pro Leu Ser Val Gln Val Lys Asp His 
65                  70                  75                  80  
Ile Asp Leu Ser Pro Lys Glu Glu Gln Ile Phe Asn Arg Leu Leu Gln 
                85                  90                  95      
Val Val Glu His Tyr Asn Met Gly Thr Gln Leu Arg Val Ala Gly Gly 
            100                 105                 110         
Trp Val Arg Asp Lys Leu Leu Gly Lys Glu Cys Tyr Asp Ile Asp Ile 
        115                 120                 125             
Ala Leu Asp Asn Met Tyr Gly Arg Glu Phe Cys Glu Lys Val Asn Glu 
    130                 135                 140                 
Tyr Leu Ser Ala Ser Gly Glu Glu Thr Gln Gly Val Gly Val Ile Gln 
145                 150                 155                 160 
Cys Asn Pro Asp Gln Ser Lys His Leu Glu Thr Ala Arg Met Arg Leu 
                165                 170                 175     
Ser Asp Val Trp Ile Asp Phe Val Asn Leu Arg Ala Glu Asp Tyr Ser 
            180                 185                 190         
Glu Asn Ser Arg Ile Pro Thr Met Lys Phe Gly Thr Ala Lys Gln Asp 
        195                 200                 205             
Ala Asp Cys Arg Asp Leu Thr Ile Asn Ser Leu Phe Tyr Asn Ile Asn 
    210                 215                 220                 
Thr Arg Ser Val Glu Asp Leu Thr Glu Arg Gly Ile Ala Asp Leu Lys 
225                 230                 235                 240 
Ser Gly Lys Ile Val Thr Pro Leu Pro Pro Lys Gln Thr Phe Leu Asp 
                245                 250                 255     
Asp Pro Leu Arg Val Leu Arg Ala Ile Arg Phe Gly Ala Arg Phe Gly 
            260                 265                 270         
Phe Ile Leu Asp Glu Glu Leu Lys Lys Ala Ala Ala Asp Glu Asp Val 
        275                 280                 285             
Arg Val Ala Ile Ala Asp Lys Ile Ser Arg Glu Arg Ile Gly His Glu 
    290                 295                 300                 
Ile Asp Leu Met Met Ser Gly Asp Gln Pro Val Asn Val Met Thr Tyr 
305                 310                 315                 320 
Ile Ala Asp Leu Lys Leu Phe Ser Ala Val Phe Ser Leu Pro Ser Asp 
                325                 330                 335     
Phe Glu Pro Ser Ile Pro Asp Gly Cys Asp Arg Leu Cys Val Ser Cys 
            340                 345                 350         
Leu Gly Thr Phe Lys Pro Tyr Trp Thr Leu Leu Ile Phe Arg 
        355                 360                 365     

<210> 11
<211> 366
<212> PRT
<213> Solanum lycopersicum


<220> 
<223> CCA2 protein|TO1

<400> 11
Met Lys Ala Leu Ser Ile Ala Val Ala Ala Phe Ser Thr Phe His Thr 
1               5                   10                  15      
Thr Arg Pro Arg Leu Phe Thr Phe Pro Asn Pro Ser Thr Ser Ser Ser 
            20                  25                  30          
Leu Leu Leu Pro Ser Phe Lys Leu Lys Arg Phe Ser Ile Phe Ser Val 
        35                  40                  45              
Gln Gln Thr Pro Pro Ala Leu Gly Phe Tyr Ala Gly Val Thr Thr Met 
    50                  55                  60                  
Val Glu Gly Ser Ala Phe Gln Pro Leu Ser Val Gln Val Lys Asp His 
65                  70                  75                  80  
Ile Asp Leu Ser Pro Lys Glu Glu Gln Ile Phe Asn Arg Leu Leu Gln 
                85                  90                  95      
Val Val Glu His Tyr Asn Met Gly Thr Gln Leu Arg Val Ala Gly Gly 
            100                 105                 110         
Trp Val Arg Asp Lys Leu Leu Gly Lys Glu Cys Tyr Asp Ile Asp Ile 
        115                 120                 125             
Ala Leu Asp Asn Met Tyr Gly Arg Glu Phe Cys Glu Lys Val Asn Glu 
    130                 135                 140                 
Tyr Leu Ser Ala Ser Gly Glu Glu Thr Gln Gly Val Gly Val Ile Gln 
145                 150                 155                 160 
Cys Asn Pro Asp Gln Ser Lys His Leu Glu Thr Ala Arg Met Arg Leu 
                165                 170                 175     
Ser Asp Val Trp Ile Asp Phe Val Asn Leu Arg Ala Glu Asp Tyr Ser 
            180                 185                 190         
Glu Asn Ser Arg Ile Pro Thr Met Lys Phe Gly Thr Ala Lys Gln Asp 
        195                 200                 205             
Ala Asp Arg Arg Asp Leu Thr Ile Asn Ser Leu Phe Tyr Asn Ile Asn 
    210                 215                 220                 
Thr Arg Ser Val Glu Asp Leu Thr Glu Arg Gly Ile Ala Asp Leu Lys 
225                 230                 235                 240 
Ser Gly Lys Ile Val Thr Pro Leu Pro Pro Lys Gln Thr Phe Leu Asp 
                245                 250                 255     
Asp Pro Leu Arg Val Leu Arg Ala Ile Arg Phe Gly Ala Arg Phe Gly 
            260                 265                 270         
Phe Ile Leu Asp Glu Glu Leu Lys Lys Ala Ala Ala Asp Glu Asp Val 
        275                 280                 285             
Arg Val Ala Ile Ala Asp Lys Ile Ser Arg Glu Arg Ile Gly His Glu 
    290                 295                 300                 
Ile Asp Leu Met Met Ser Gly Asp Gln Pro Val Lys Ala Met Thr Tyr 
305                 310                 315                 320 
Ile Ala Asp Leu Lys Leu Phe Ser Ala Val Phe Ser Leu Pro Ser Asp 
                325                 330                 335     
Phe Glu Pro Ser Ile Pro Asp Gly Cys Asp Arg Leu Cys Val Ser Cys 
            340                 345                 350         
Leu Gly Thr Phe Lys Pro Tyr Trp Thr Leu Leu Ile Phe Arg 
        355                 360                 365     

<210> 12
<211> 1000
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> CCA1 promotor|NCIMB43511, NCIMB43512

<400> 12
atggtatgaa atttaccata tacatatcta tatatattac tttggtgtgt taaaagagtg      60

agaatgagat attacatcaa aataattttt cttccttatt tatttgtttg gtttcttaag     120

taaaatatat attttttgtt aaattctgat ttctagttat agtacaagaa aaacttgttg     180

aatacacctt tatcggtgaa atatccttaa ggacagtgat ataggtatgc ctcaagttac     240

gtgatttcca atagttttac aacaataata atacaaatat aaatcattct ttccatcttt     300

tttgtctttc tttctctcac tttatacaaa cacaaattgt gtaaaaaatt atacaaaatt     360

tgtgtttgta taaaacgaga gagagatttc ataaacaaat attttaactt gattcaattg     420

tatacgaatt taaagtttat gcagatatac aaactgaatc attcataaat atacatagta     480

gttagatata tacaattatc taattgatat acatatacaa ttcacctctc tcccctctct     540

atcccactct agctcgcctc tctcatctct ctctctcaat cttgctcgtc gctctaacct     600

aacacagaga acatatacat atacaaacac aatattcata gacacagacg aatgagcgct     660

cgattaatat aaattggcgc gatttataca aattagatgc tccataacaa acataatctg     720

attatgaagc ataaataaca aaattatagc tgagaactct aatataaatt tttttttatc     780

tttgatacac ctaaaattta ctcaataaaa tgtgactata tttattctaa gctaattaca     840

ttattgtact tattcatgtt ttaactttaa ctatttttat ttttttttta aataaaaaaa     900

taaacttgcc acatcatgaa agatgtagtt gggatgaccc gacccgtttt ctatgcttat     960

gagagcgggt catcacttgt ccgttagaaa gagagaagaa                          1000


<210> 13
<211> 1001
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> CCA1 promotor|TO1

<400> 13
aatggtatga aatttaccat atacaatatc tatatatatt actttggtgt gttaaaagag      60

tgagaatgag atattacatc aaaataattt ttcttcctta tttatttgtt tggtttctta     120

agtaaaatat atattttttg ttaaattctg atttctagtt atagtacaag aaaaacttgt     180

tgaatacacc tttatcggtg aaatatcctt aaggacagtg atataggtat gcctcaagtt     240

acgtgatttc caatagtttt acaacaataa taatacaaat ataaatcatt ctttccatct     300

tttttgtctt tctttctctc actttataca aacacaaatt gtgtaaaaaa ttatacaaaa     360

tttgtgtttg tataaaacga gagagagatt tcataaacaa atattttaac ttgattcaat     420

tgtatacgaa tttaaagttt atgcagatat acaaactgaa tcattcataa atatacatag     480

tagttagata tatacaatta tctaattgat atacatatac aattcacctc tctcccctct     540

ctatcccact ctagctcgcc tctctcatct ctctctctca atcttgctcg tcgctctaac     600

ctaacacaga gaacatatac atatacaaac acaatattca tagacacaga cgaatgagcg     660

ctcgattaat ataaattggc gcgatttata caaattagat gctccataac aaacataatc     720

tgattatgaa gcataaataa caaaattata gctgagaact ctaatataaa ttttttttta     780

tctttgatac acctaaaatt tactcaataa aatgtgacta tatttattct aagctaatta     840

cattattgta cttattcatg ttttaacttt aactattttt attttttttt aaataaaaaa     900

ataaacttgc cacatcatga aagatgtagt tgggatgacc cgacccgttt tctatgctta     960

tgagagcggg tcatcacttg tccgttagaa agagagaaga a                        1001


<210> 14
<211> 1002
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> CCA2 promotor|NCIMB43511

<400> 14
aagactgaag ggtatggaat ttaccatata ctatatctat atatattact ttggtttgtt      60

aaaagaggga caatgagata ttacatcaaa ataatttttc ttttcttcct tatttattta     120

tttggtttct taagtaaaat atattttttt gttagattct ttattcctaa ttttagtaca     180

agaaaaactt gttgaataca catttactgg tgaaatatcc ttaaggataa tgacataggc     240

acgcctcaag ttacgtgact tccaatagtt ttacaacaat aattatacaa atataaatat     300

ttcttgccat ctttttttgt ctctctctca ctttatacaa acacaagtta tacaaaagac     360

aatataaaat ttgtgtttgt ataaaacgag agagagattt catatacaaa tgttttaact     420

tgattcaatt atatacgaat ttaaatttta tgtagatata tagactgaat cattcattaa     480

tatacatagt agttaaatat atacaattat ctaatcggta tacatataca attcacctct     540

ctccactctc tacccactct agctcgtctc tctcatctct ctctctcaat ctcgctcgtc     600

gctctaacca aacacagaga acatatacat atacaaacac aatttcatag acacagacga     660

atgagcgctc gattaataca attggagcga tttatacaaa ttagatgctc cataacaaac     720

ataatctggt tatgaagcgt aaataacaaa attatagctg tagagctcta atataatttt     780

ttatctttga tactcctaaa atttactcaa taaaatgtga ctatatttat tctaagctaa     840

ttacattatt gtatttattc atgttttaac tttaactata tattttttta aaaataaaaa     900

aataaacttg ccacatcatg aaagatgtgg ttgagatgac ccgacccgtt tcttatgctt     960

atgagagcgg gtcatcactt gtccgttaga aagagagaag aa                       1002


<210> 15
<211> 1002
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> CCA2 promotor|NCIMB43512

<400> 15
aagactgaag ggtatggaat ttaccatata ctatatctat atatattact ttggtttgtt      60

aaaagaggga caatgagata ttacatcaaa ataatttttc ttttcttcct tatttattta     120

tttggtttct taagtaaaat atattttttt gttagattct ttattcctaa ttttagtaca     180

agaaaaactt gttgaataca catttactgg tgaaatatcc ttaaggataa tgacataggc     240

acgcctcaag ttacgtgact tccaatagtt ttacaacaat aattatacaa atataaatat     300

ttcttgccat ctttttttgt ctctctctca ctttatacaa acacaagtta tacaaaagac     360

aatataaaat ttgtgtttgt ataaaacgag agagagattt catatacaaa tgttttaact     420

tgattcaatt atatacgaat ttaaatttta tgtagatata tagactgaat cattcattaa     480

tatacatagt agttaaatat atacaattat ctaatcggta tacatataca attcacctct     540

ctccactctc tacccactct agctcgtctc tctcatctct ctctctcaat ctcgctcgtc     600

gctctaacca aacacagaga acatatacat atacaaacac aatttcatat acacagacga     660

atgagcgctc gattaataca attggagcga tttatacaaa ttagatgctc cataacaaac     720

ataatctggt tatgaagcgt aaataacaaa attatagctg tagagctcta atataatttt     780

ttatctttga tactcctaaa atttactcaa taaaatgtga ctatatttat tctaagctaa     840

ttacattatt gtatttattc atgttttaac tttaactata tattttttta aaaataaaaa     900

aataaacttg ccacatcatg aaagatgtgg ttgagatgac ccgacccgtt tcttatgctt     960

atgagagcgg gtcatcactt gtccgttaga aagagagaag aa                       1002


<210> 16
<211> 988
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> CCA2 promotor|TO1

<400> 16
aagactgaag ggtatggaat ttaccatata ctatatctat atatattact ttggtttgtt      60

aaaagaggga caatgagata ttacatcaaa ataatttttc ttttcttcct tatttattta     120

tttggtttct taagtaaaat atattttttg ttagattctt tattcctaat tttagtacaa     180

gaaaaacttg ttgaatacac atttactggt gaaatatcct taaggataat gacataggca     240

cgcctcaagt tacgtgactt ccaatagttt tacaacaata attatacaaa tataaatatt     300

tcttgccatc tttttttgtc tctctctcac tttatacaaa cacaagttat acaaaagaca     360

atataaaatt tgtgtttgta taaaacgaga gagagatttc atatacaaat gttttaactt     420

gattcaatta tatacgaatt taaattttat gcagatatat agactgaatc attcattaat     480

atacatagta gttaaatata tacaattatc taatcggtat acatatacaa ttcacctctc     540

tccactctct acccactcta gctcgtctct ctcaatctcg ctcgtcgctc taaccaaaca     600

cagaaaacat atacatatac aaacacaatt tcatagacac agacgaatga gcgctcgatt     660

aatacaattg gagcgattta tacaaattag atgctccata acaaacataa tctggttatg     720

aagcgtaaat aacaaaatta tagctgtaga gctctaatat aattttttat ctttgatact     780

cctaaaattt actcaataaa atgtgactat atttattcta agctaattac attattgtat     840

ttattcatgt tttaacttta actatatatt tttttaaaaa taaaaaaata aacttgccac     900

atcatgaaag atgtagttga gatgacccga cccgtttctt atgcttatga gagcgggtca     960

tcacttgtcc gttagaaaga gagaagaa                                        988


<210> 17
<211> 1001
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> Promoter of the wildtype CCA2 gene

<400> 17
aagactgaag ggtatggaat ttaccatata ctatatctat atatattact ttggtttgtt      60

aaaagaggga caatgagata ttacatcaaa ataatttttc ttttcttcct tatttattta     120

tttggtttct taagtaaaat atattttttg ttagattctt tattcctaat tttagtacaa     180

gaaaaacttg ttgaatatac atttactggt gaaatatcct taaagataat gacataggca     240

cgcctcaagt tacgtgactt ccaatagttt tacaacaata attatacaaa tataaatatt     300

tcttgccatc tttttttgtc tctctctcac tttatacaaa cacaagttat acaaaagaca     360

atataaaatt tgtgtttgta taaaacgaga gagagatttc atatacaaat gttttaactt     420

gattcaatta tatacgaatt taaattttat gcagatatat agactgaatc attcattaat     480

atacatagta gttaaatata tacaattatc taatcggtat acatatacaa ttcacctctc     540

tccactctct acccactcta gctcgtctct ctcatctctc tctctcaatc tcgctcgtcg     600

ctctaaccaa acacagagaa catatacata tacaaacaca atttcataga cacaaacgaa     660

tgagcgctcg attaatacaa ttggagcgat ttatacaaat tagatgctcc ataacaaaca     720

taatctggtt atgaagcgta aataacaaaa ttatagctgt agagctctaa tataattttt     780

tatctttgat actcctaaaa tttactcaat aaaatgtgac tatatttatt ctaagctaat     840

tacattattg tatttattca tgttttaact ttaactatat atttttttaa aaataaaaaa     900

ataaacttgc cacatcatga aagatgtagt tgagatgacc cgacccgttt cttatgctta     960

tgagagcggg tcatcacttg tccgttagaa agagagaaga a                        1001


<210> 18
<211> 17
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> Deletion in the promoter sequence

<400> 18
tttttaaata tttattt                                                   17


<210> 19
<211> 17
<212> DNA
<213> Solanum lycopersicum


<220> 
<223> Deletion in the promoter sequence

<400> 19
aaatatttat ttttttt                                                   17


