               SEQUENCE LISTING

<110> CSIC - Consejo Superior de Investigaciones Científicas
      Fundación Científica de la Asociación Española Contra el
      Cáncer

<120> Tools and methods to detect and isolate colibactin producing bacteria

<130> PCT1641.1497

<150> EP19383077
<151> 2019-12-04

<160> 11

<170> BiSSAP 1.3.6

<210> 1
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Isolated peptide from colibactinH protein

<400> 1
Leu Asp Asp His Gly Asn Pro Val Ala Asp Gly Glu Glu Gly Glu Leu 
1               5                   10                  15      
Tyr Leu Ala Gly 
            20  

<210> 2
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Isolated peptide from colibactinH protein

<400> 2
Trp Arg Asp Gly Glu Ser Gln Gln Ile His Tyr Ile Gly Arg Asn Asp 
1               5                   10                  15      
Phe Gln Ile Lys 
            20  

<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Isolated peptide from colibactinC protein

<400> 3
Ala Ala Gly Asp Arg Ile Tyr Ala Val Ile Arg Gly Ser Ala Val Asn 
1               5                   10                  15      
Asn Asp Gly Lys 
            20  

<210> 4
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Isolated peptide from colibactinB protein

<400> 4
Phe Asn Thr Leu Val Val Leu Glu Asn Tyr Pro Val Asp Met Thr Leu 
1               5                   10                  15      
Leu Ser Cys Ala 
            20  

<210> 5
<211> 1599
<212> PRT
<213> Escherichia coli


<400> 5
Met Glu Gln Gln Gly Ile Met Arg Gln Leu Pro Thr Asp Asp Gln Thr 
1               5                   10                  15      
Ile Val Asp Tyr Leu Tyr Arg Ile Ala Gly Glu Tyr Gly Glu Lys Ala 
            20                  25                  30          
Ala Val Leu Met Gly Asp Ala Ala Leu Ser Tyr His Asp Leu Asn Ala 
        35                  40                  45              
Arg Ser Asn Gln Leu Ala His Tyr Leu Arg Gly Leu Gly Ile Gly Glu 
    50                  55                  60                  
Asp Arg Val Val Ala Ile Arg Leu Pro Arg Gly Met Ala Met Leu Ile 
65                  70                  75                  80  
Ala Ile Phe Ala Ile Val Lys Ala Gly Gly Ala Tyr Leu Pro Leu Ala 
                85                  90                  95      
Tyr Asn Ala Pro Pro Arg Ser Arg Ile Glu Asn Ile Leu Ser Asn Ser 
            100                 105                 110         
Gly Ala Val Cys Leu Ile Gly Thr Asp Asp Gly Asp Arg Trp Pro Ile 
        115                 120                 125             
Pro Arg Val Glu Ile Asp Ser Ala Ala Val Ser Ala Met Pro Thr Thr 
    130                 135                 140                 
Asp Leu Arg Tyr Arg Pro His Ala Arg Gln Leu Ala Tyr Ile Ile Tyr 
145                 150                 155                 160 
Thr Ser Gly Ser Thr Gly Val Pro Lys Gly Val Ala Thr Glu His Ala 
                165                 170                 175     
Ala Leu Leu Asn Arg Ile Val Trp Met Gln Asn Ala Tyr Pro Ile Ser 
            180                 185                 190         
Ser Gln Asp Val Leu Phe Gln Lys Thr Val Tyr Thr Phe Asp Val Ser 
        195                 200                 205             
Val Trp Glu Met Phe Trp Trp Ala Met Tyr Gly Ala Ser Val Val Leu 
    210                 215                 220                 
Leu Pro Ser Gly Leu Glu Ser Asp Pro Arg Thr Leu Ala Arg Leu Ile 
225                 230                 235                 240 
Gln Arg His Arg Val Ser Val Val His Phe Val Pro Ser Met Leu Asn 
                245                 250                 255     
Leu Phe Val Glu Tyr Leu Glu Met Lys Gln Asp Pro Arg Leu Thr Ala 
            260                 265                 270         
Ser Leu Arg Leu Val Phe Ser Ser Gly Glu Lys Leu Thr Val His Ser 
        275                 280                 285             
Val Ala Arg Phe Tyr Gln Ser Val Ala Gln Gly Asp Leu Ile Asn Leu 
    290                 295                 300                 
Tyr Gly Pro Thr Glu Ala Ala Ile Asp Val Ser His His Arg Cys Leu 
305                 310                 315                 320 
Arg Gly Tyr Asp Tyr Asp Asp Ile Pro Ile Gly Gln Ala Ile Asp Gly 
                325                 330                 335     
Cys Arg Leu Tyr Val Leu Asp Asp His Gly Asn Pro Val Ala Asp Gly 
            340                 345                 350         
Glu Glu Gly Glu Leu Tyr Leu Ala Gly Ile Gly Leu Ala Arg Gly Tyr 
        355                 360                 365             
Leu Asn Asn Val Ala Leu Thr Asp Arg Cys Phe Thr Ile His Pro Thr 
    370                 375                 380                 
Leu Arg His Leu Gly Lys Pro Glu Arg Leu Tyr Lys Thr Gly Asp Leu 
385                 390                 395                 400 
Val Trp Arg Asp Gly Glu Ser Gln Gln Ile His Tyr Ile Gly Arg Asn 
                405                 410                 415     
Asp Phe Gln Ile Lys Ile Arg Gly Leu Arg Val Glu Leu Gly Glu Ile 
            420                 425                 430         
Glu Ala His Ala Met Arg Phe Pro Gly Val Gln Gln Ala Val Val Val 
        435                 440                 445             
Ala Asp Gln Asp Asp Pro Asp Asn Gln Leu Ile Tyr Ala Phe Val Val 
    450                 455                 460                 
Ser Ser Val Pro Leu Asn Leu Ala Ala Leu Met Asp Ala Leu Ser Lys 
465                 470                 475                 480 
Asn Leu Pro Ala Tyr Met Leu Pro Asn Arg Leu Leu Ala Met Ser Glu 
                485                 490                 495     
Leu Pro Leu Ser Asp Asn Gly Lys Cys Cys Arg Lys Thr Leu Leu Asp 
            500                 505                 510         
Leu Ala Arg Ala Tyr Ser Ala Ser Arg Val Asp Leu Arg Glu Thr Pro 
        515                 520                 525             
Ala Val Arg Tyr Leu Pro Leu Ser Ser Ala Gln Ser Ser Met Trp Phe 
    530                 535                 540                 
Met Gln Gln Leu Ala Pro His Thr Ala Leu Tyr Asn Asn Pro Thr Ala 
545                 550                 555                 560 
Leu Leu Leu Glu Gly Glu Leu Asp Arg Thr Arg Met Asp Gly Ala Ile 
                565                 570                 575     
Arg Gln Leu Met Ser Arg His Thr Leu Leu Arg Ala Met Ala Glu Thr 
            580                 585                 590         
His Asn Gly Gln Pro Val Leu Ala Val Pro Gln Cys Val Ser Ser Gln 
        595                 600                 605             
Ala Leu Leu Thr Ile Val Pro Leu Pro Ser Val Ser Asp Asp Asn Ala 
    610                 615                 620                 
Leu Gln Ala Met Ile Asn Gln Arg Ala Ala His Pro Met Pro Leu Thr 
625                 630                 635                 640 
Ser Gly Thr Pro Leu Cys Arg Phe Glu Leu Leu Thr Leu Asp Asp Asp 
                645                 650                 655     
Arg Ser Val Leu Leu Ile His Leu His His Ile Ile Ser Asp Gly Trp 
            660                 665                 670         
Ser Lys Gly Val Leu Leu Arg Glu Leu Gln Ala Ala Tyr Asn Gly Glu 
        675                 680                 685             
Ser Leu Thr Pro Glu Pro Leu Leu Glu Tyr Ala Asp Tyr Met Glu Tyr 
    690                 695                 700                 
Gln Glu Glu Trp Arg Gln Ser Asp Ala Tyr Gln Asp Ala Met Arg Tyr 
705                 710                 715                 720 
Trp Gln Asn Thr Leu Ala Gly Thr Leu Pro Ile Leu Asp Ile Pro Thr 
                725                 730                 735     
Asp Gln Pro Arg Gln Lys Val Ala Arg Tyr Gln Gly Ala Phe Val Ala 
            740                 745                 750         
Phe Ala Leu Ser Ala Asn Thr Cys Glu Arg Val Leu Ala Ala Ala Arg 
        755                 760                 765             
Ala Gln Arg Val Ser Leu Tyr Asn Tyr Leu Leu Thr Ala Phe Val Leu 
    770                 775                 780                 
Leu Leu His Arg Asn Ala Arg Gln Gln Glu Tyr Ile Val Gly Met Pro 
785                 790                 795                 800 
Ile Ala Ala Arg Leu Thr Lys Glu Gln Glu His Met Ile Ala Pro Leu 
                805                 810                 815     
Val Asn Val Leu Pro Leu Arg Leu Pro Leu Asp Glu Ala Ala Ser Phe 
            820                 825                 830         
Ser Glu Leu Val Gln Thr Ile Arg Gly Ile Leu Phe Ala Ala Phe Arg 
        835                 840                 845             
His Gln Arg Leu Glu Phe Thr Asp Ile Val Arg Ala Val Asn Val Asp 
    850                 855                 860                 
Arg Ser Ala Gly His Phe Pro Ile Tyr Gln Cys Met Phe Gln Leu Asp 
865                 870                 875                 880 
Asn Met Pro Leu Ala Ser Pro Thr Leu Asn Gly Val Asn Val Thr Pro 
                885                 890                 895     
Leu Leu Leu Asp Thr Ser Ala Ser Gln Val Asp Ile Ser Leu Ser Met 
            900                 905                 910         
Gln His Ile Asp Gly Arg Ile Thr Gly Thr Phe Glu Tyr Asp Ala Gly 
        915                 920                 925             
Leu Tyr Ser Ala Asp Arg Ile Gln His Leu Val Ala Gln Trp Arg Glu 
    930                 935                 940                 
Leu Leu Asp Glu Ala Ser Ser Gln Pro Thr Gln Leu Val Arg Asp Leu 
945                 950                 955                 960 
Ile Arg Phe Thr Pro Arg Glu His Ala Trp Leu Ala Arg His Asn Ala 
                965                 970                 975     
Thr Glu Val Ala Leu Pro Pro Val Asp Asn Leu Leu Ala Leu Val Leu 
            980                 985                 990         
Pro His Cys Gln Gln Arg Pro Thr Gln Val Ala Leu Arg His Ala Asp 
        995                 1000                1005            
Asp Ala Met Thr Tyr Gly Glu Leu Gln Gln Ala Thr Met Gln Met Cys 
    1010                1015                1020                
Thr Trp Leu Arg Ala Gln Gly Val Lys Arg Gly Glu Ser Val Ala Leu 
1025                1030                1035                1040
Gln Leu Pro Phe Cys Phe Glu Leu Ile Ile Ala Gln Leu Ala Ile Leu 
                1045                1050                1055    
Ser Leu Gly Ala Ser Tyr Val Pro Leu Asp Gly Asn Ala Pro Ala Ala 
            1060                1065                1070        
Arg Asn Ala Leu Ile Leu Ala Gln Ala Thr Pro Cys Met Leu Leu Val 
        1075                1080                1085            
Ala Gln Pro Leu Glu Ser Pro His Gly Leu Thr Ile Pro Trp Val Leu 
    1090                1095                1100                
Val Pro Asp Trp Arg Ser Leu Leu Thr Glu Ile Pro Asn Leu Pro Val 
1105                1110                1115                1120
Ser Val Ala Pro Asp Ala Leu Asp Cys Asp Ala Val Val Ile Phe Thr 
                1125                1130                1135    
Ser Gly Thr Thr Gly Gln Pro Lys Gly Val Arg Leu Ser Gln Arg Asn 
            1140                1145                1150        
Leu Val Asn Leu Thr Ala Ser Phe Ile Ser Ser Tyr Gln Val Thr His 
        1155                1160                1165            
Gln Asp Val Leu Leu Pro Ile Thr Ser Val Ala Ser Ala Ser Phe Val 
    1170                1175                1180                
Gly Glu Val Leu Pro Leu Leu Ala Ala Gly Gly Thr Leu Val Leu Ala 
1185                1190                1195                1200
Gln Lys Ala Gln Ser Leu Asp Ser Asp Ala Leu Ile Ala Leu Leu Ala 
                1205                1210                1215    
Ser Gln Arg Val Thr Ile Leu Ser Thr Thr Pro Ser Leu Ser Ala Ser 
            1220                1225                1230        
Leu Ser Val Leu Ala Gln Ser Met Gly Ser Leu Arg Leu Phe Leu Cys 
        1235                1240                1245            
Gly Gly Glu Ala Leu Glu Tyr Glu Gln Ile Ala Pro Leu Leu Pro His 
    1250                1255                1260                
Met Ala Val Val Asn Gly Tyr Gly Leu Thr Glu Ser Gly Ile Cys Ser 
1265                1270                1275                1280
Thr Tyr Phe Pro Val Ala Lys Arg Arg Glu Gln Glu Thr Gly Ala Leu 
                1285                1290                1295    
Pro Ile Gly Arg Pro Ile Gln Asn Thr Gln Ala Tyr Val Val Asp Ala 
            1300                1305                1310        
Tyr Asn Arg Leu Val Pro Pro Gly Ala Cys Gly Glu Leu Cys Phe Ser 
        1315                1320                1325            
Gly Leu Gly Ile Ser Pro Gly Tyr Leu Asp Ala Arg Gln Asp Pro Glu 
    1330                1335                1340                
Arg Phe Val Glu Leu Pro Glu Tyr Pro Gly Val Arg Val Leu Lys Thr 
1345                1350                1355                1360
Gly Asp Arg Ala Arg Trp Ala Thr Asp Gly Met Leu Phe Tyr Leu Gly 
                1365                1370                1375    
Arg Gln Asp Arg Gln Val Gln Ile Arg Gly Tyr Arg Val Glu Leu Gly 
            1380                1385                1390        
Asp Ile Glu Ser Leu Leu Lys Gln His Pro Asp Ile Ala Asp Ala Trp 
        1395                1400                1405            
Val Asp Val Arg Arg Asn Ala Ala Ala Thr Pro Leu Leu Val Ala Phe 
    1410                1415                1420                
Tyr Cys Ser Val Asn Gly Val Ala Leu Asp Ala Gln Gln Leu Arg Val 
1425                1430                1435                1440
Trp Leu Ser Leu Arg Leu Pro Leu His Met Leu Pro Leu Leu Tyr Val 
                1445                1450                1455    
Pro Leu Ser Ala Met Pro Leu Gly Val Asn Gly Lys Ile Asp Pro Gln 
            1460                1465                1470        
Cys Leu Pro Leu Val Asp Leu Arg Gln Leu Glu Gly Pro Gly Glu Tyr 
        1475                1480                1485            
Val Pro Pro Ala Thr Glu Leu Glu Gln Arg Leu Ala Glu Ile Trp Gln 
    1490                1495                1500                
Gln Leu Leu Gly Leu Glu Arg Val Gly Thr Thr Thr Asn Phe Phe Asp 
1505                1510                1515                1520
Leu Gly Gly His Ser Leu Leu Leu Val Gln Met Gln Gln Tyr Ile Gly 
                1525                1530                1535    
Gln Gln Cys Gly Gln His Val Ala Leu Val Asp Leu Leu Arg Phe Thr 
            1540                1545                1550        
Thr Ile Lys Arg Leu Ala Glu Phe Leu Leu Ala Pro Asp Ala Ala Gln 
        1555                1560                1565            
Gly Thr Thr Gly Asp Gln Thr Gln Leu Arg Ala Ala Lys Gln Arg Leu 
    1570                1575                1580                
Ala Phe Gly His Thr Arg Trp Ala Ala Thr Thr Asp Ser His His 
1585                1590                1595                

<210> 6
<211> 866
<212> PRT
<213> Escherichia coli


<400> 6
Met Glu Tyr Ala Ser Glu Met Asn Gly Met Glu Ile Ala Ile Ile Gly 
1               5                   10                  15      
Met Ala Val Arg Phe Pro Gln Ser Arg Thr Leu His Glu Phe Trp His 
            20                  25                  30          
Asn Ile Val Gln Gly Lys Glu Cys Val Thr Phe Phe Ser Glu Glu Glu 
        35                  40                  45              
Leu Leu Ala Glu Gly Val Glu Gln Ser Thr Leu Asp Asn Pro Ala Tyr 
    50                  55                  60                  
Val Arg Ala Lys Pro Tyr Ile Lys Gly Ile Cys Asp Phe Asp Ala Ala 
65                  70                  75                  80  
Phe Phe Gly Tyr Ser His Lys Glu Ala Gln Thr Leu Asp Pro Lys Ser 
                85                  90                  95      
Arg Val Leu His Glu Val Ala Tyr His Ala Leu Glu Asp Ala Gly Tyr 
            100                 105                 110         
Ala Gln Arg Thr Ser Asp Leu Ile Thr Gly Val Phe Val Gly Ala Ser 
        115                 120                 125             
Glu Asp Val Asp Trp Leu Arg Arg Ser Leu Ser Gln Ile Gly Gly Asp 
    130                 135                 140                 
Ala Leu Asn Arg Phe Glu Ser Gly Ile Tyr Gly His Lys Asp Leu Leu 
145                 150                 155                 160 
Ala His Leu Ile Ala Tyr Ser Leu Asn Leu Asn Gly Pro Val Tyr Ser 
                165                 170                 175     
Leu Tyr Thr Ser Cys Ser Thr Ser Leu Ser Ala Thr His Ile Ala Cys 
            180                 185                 190         
Arg Ser Leu Leu Phe Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Ile 
        195                 200                 205             
Thr Ile Asp Leu Pro Gln Lys Ser Gly Tyr Phe Cys Gln Gln Gly Met 
    210                 215                 220                 
Ile His Ser Thr Asp Gly His Cys Arg Pro Phe Asp Ser Gln Ala Ser 
225                 230                 235                 240 
Gly Thr Leu Phe Gly Asp Gly Ala Gly Val Val Val Leu Arg Arg Leu 
                245                 250                 255     
Glu Asp Ala Leu Ala Ala Gly Asp Arg Ile Tyr Ala Val Ile Arg Gly 
            260                 265                 270         
Ser Ala Val Asn Asn Asp Gly Lys Gln Lys Ile Gly Phe Val Ala Pro 
        275                 280                 285             
Gly His Glu Gly Gln Lys Ala Val Ile Cys Ala Ala Cys His Leu Ala 
    290                 295                 300                 
Glu Val Ser Pro Glu Ser Ile Gly Tyr Val Glu Thr His Gly Thr Gly 
305                 310                 315                 320 
Thr Arg Ile Gly Asp Leu Ile Glu Phe Ala Ala Leu Thr Glu Ala Phe 
                325                 330                 335     
Asp Thr Ser His Arg Gln Tyr Cys Ala Leu Gly Ala Val Lys Ala Asn 
            340                 345                 350         
Ile Gly His Thr His Ala Ala Ala Gly Val Ala Gly Leu Ile Lys Thr 
        355                 360                 365             
Ala Leu Val Leu His His Arg Thr Ile Pro Pro Leu Ala Asn Tyr Gln 
    370                 375                 380                 
Met Pro Asn Ser Lys Leu Asp Leu Ala His Ser Pro Phe Tyr Ile Pro 
385                 390                 395                 400 
Ile Gln Pro Gln Glu Trp Pro Ala Ser Arg Met Pro Pro Arg Ala Gly 
                405                 410                 415     
Val Ser Ser Phe Gly Ile Gly Gly Thr Asn Val His Met Ile Leu Glu 
            420                 425                 430         
Gly Leu Asn Pro Ala Val Arg Asp Asp His Asp Gln Val Arg Ala Pro 
        435                 440                 445             
Val Phe Ile Pro Leu Ser Ala Pro Ser Phe Glu Gln Leu Asp Glu Leu 
    450                 455                 460                 
Thr Gln Gln Leu Thr Pro Leu Leu Ala Thr Leu Asp Ala Ser Thr Leu 
465                 470                 475                 480 
Ala Tyr Thr Gln Gln Val Ala Arg Pro Val Phe Asp Cys Arg Arg Val 
                485                 490                 495     
Ile Gln Val Glu Asn Asp Gly Thr Gln Ala Met Leu Ala Ser Leu Asp 
            500                 505                 510         
Asn Leu Met Pro Asp Ala Pro Trp Gly Leu His Cys Pro Asp Leu Arg 
        515                 520                 525             
Thr Thr Asn Asp Cys Thr Tyr Ala Gln Trp Leu Ala His Ser Ala His 
    530                 535                 540                 
Tyr Gln Arg Glu Ala Thr Ala Leu Thr Ala Leu Leu Asp Gly Met Asn 
545                 550                 555                 560 
Ile Pro Pro Ala Tyr Cys His Ala Glu Thr Trp Ala Ala Gln Ala Asn 
                565                 570                 575     
Ser Ser Leu Leu Ile Arg Gly Cys Gln Thr Ile Ala Ala Leu Lys Thr 
            580                 585                 590         
Trp Met Asn Leu Leu Pro Thr Leu Thr Leu Leu Ser Gly Ala Gly Thr 
        595                 600                 605             
Gly Leu Leu Pro Ala Ala Ala Ala Ser Gly Met Ile Ala Thr Gln Asp 
    610                 615                 620                 
Val Leu His Leu Leu Trp Glu Met Glu Gln Lys Ala Leu His Leu Trp 
625                 630                 635                 640 
Leu Pro Glu Arg His Glu Pro Ile Pro Gly Tyr Val Leu Ala Trp Gln 
                645                 650                 655     
Gly Asn Pro Ile Thr Asp Ala Gln Arg Asn Asp Arg Gly Phe Trp Ser 
            660                 665                 670         
Glu Ala Leu Leu Ala Asp Thr Arg Glu Leu Gly Glu Gly Val His Ser 
        675                 680                 685             
Ile Asn Trp Val Arg Leu Pro Pro Glu Ile Arg Glu Asp Val Asp Val 
    690                 695                 700                 
Leu Arg Tyr Val Ala Gln Leu Trp Cys Ala Gly Ile Asn Val Asp Trp 
705                 710                 715                 720 
Ala Val Trp Tyr Gly Thr Pro Leu Pro Gln Arg Gly Ser Ala Ser Ala 
                725                 730                 735     
Tyr Pro Phe Ala His Asn His Tyr Pro Leu Pro Gly Arg Val Met Gly 
            740                 745                 750         
Ser Val Glu Thr Gln Pro Glu Ala Gly Pro Glu Thr His His Pro Tyr 
        755                 760                 765             
Gln Ala Arg Pro Val Leu Ser Val Pro Phe Val Ala Ala His Ser Arg 
    770                 775                 780                 
Gly Met Gln Tyr Ile Thr Gly Leu Met Glu Leu Leu Leu Glu Ile Ser 
785                 790                 795                 800 
Pro Val Gly Val Asp Asp Asp Phe Phe Glu Leu Gly Gly His Ser Leu 
                805                 810                 815     
Leu Val Thr Gln Leu Thr Ser Arg Leu Glu Arg Asp Phe Asn Val His 
            820                 825                 830         
Ile Asp Leu Leu Thr Leu Met Glu Asn Pro Asn Pro Arg Asn Ile Tyr 
        835                 840                 845             
Ala His Ile Ala Ala Gln Leu Gly Gly Glu Asp Asn Leu Glu Ile Ala 
    850                 855                 860                 
Cys Gln 
865     

<210> 7
<211> 20
<212> PRT
<213> Artificial sequence


<220> 
<223> Variable region of antibody of invention

<400> 7
Trp Arg Asp Gly Glu Ser Gln Gln Ile His Tyr Ile Gly Arg Asn Asp 
1               5                   10                  15      
Phe Gln Ile Lys 
            20  

<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> ClbB1 reverse primer 1

<400> 8
ccatttcccg tttgagcaca c                                              21


<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> clbB1 forward primer 1

<400> 9
gatttggata ctggcgataa ccg                                            23


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> clbB2 reverse primer 1

<400> 10
gcgctctatg ctcatcaacc                                                20


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> clbB2 forward primer 1

<400> 11
gcgcatcctc aagagtaaat a                                              21


