﻿               SEQUENCE LISTING

<110> Universitaet zu Koeln

<120> Broadly neutralizing antibodies against HIV

<130> UK0702P-WO

<150> EP19212986.4
<151> 2019-12-02

<160> 80

<170> BiSSAP 1.3.6

<210> 1
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 1-18

<400> 1
Gln Gly Arg Leu Phe Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Trp Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Arg Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Leu Glu Leu Lys Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Ser Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Arg Ala Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Ala Val Ile 
        115                 120                 125             
Val Ser Ser 
    130     

<210> 2
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 1-18

<400> 2
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Arg Ala Ser Gln Gly Leu Asp Ser Ser 
            20                  25                  30          
His Leu Ala Trp Tyr Arg Phe Lys Arg Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Thr Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 3
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 1-21

<400> 3
Gln Arg Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Gln Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 4
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 1-21

<400> 4
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Gly Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Thr Ser Thr Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 5
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 1-33

<400> 5
Gln Gly Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Arg Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 6
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 1-33

<400> 6
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Gly Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Thr Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Val Gln 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 7
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 1-54

<400> 7
Gln Gly Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Gln Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Asp Leu Gln Ser Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Ser His Met Asp Val Trp Gly Gly Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 8
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 1-54

<400> 8
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Ser Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Ala Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 9
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 1-55

<400> 9
Gln Arg Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Pro Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Arg Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 10
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 1-55

<400> 10
Glu Ala Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Gly Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Ala Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 11
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 2-10

<400> 11
Gln Gly Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr His Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Tyr Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Gln Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asn Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 12
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 2-10

<400> 12
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Arg Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Ala Ser Thr Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 13
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 2-22

<400> 13
Gln Gly Arg Leu Phe Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Arg Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 14
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 2-22

<400> 14
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Gly Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Ala Thr Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Lys Val Gln 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 15
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 2-27

<400> 15
Gln Gly Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Tyr Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Arg Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 16
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 2-27

<400> 16
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Gly Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Ala Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 17
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 2-47

<400> 17
Gln Arg Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Tyr Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Gln Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Thr Leu Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 18
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 2-47

<400> 18
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Ser Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Ala Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ala 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 19
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 3-59

<400> 19
Gln Arg Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Trp Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Gln Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Gly Val Tyr Leu Glu Leu Lys Gly Leu Gln Leu Asp Asp 
                85                  90                  95      
Ser Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Arg Ala Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Ala Val Ile 
        115                 120                 125             
Val Ser Ser 
    130     

<210> 20
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 3-59

<400> 20
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ser Phe Ser Cys Arg Ala Ser Glu Gly Leu Asp Thr Ser 
            20                  25                  30          
Gln Leu Ala Trp Tyr Arg Phe Lys Arg Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Ala Thr Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Asn Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Ala Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 21
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 5-18

<400> 21
Gln Arg Arg Leu Phe Gln Ser Gly Thr Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Gln Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Phe Glu Leu Arg Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Met Tyr Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ala 
    130     

<210> 22
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 5-18

<400> 22
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Lys Ala Ser Glu Gly Leu Ser Ser Ser 
            20                  25                  30          
Asp Leu Ala Trp Tyr Arg Phe Lys Gly Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Thr Ser Thr Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 23
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 8-10

<400> 23
Gln Gly Arg Leu Phe Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Trp Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Arg Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Leu Glu Leu Lys Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Ser Gly Ile Tyr Phe Cys Ala Arg Asp Pro Phe Gly Asp Arg Ala Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Ala Val Ile 
        115                 120                 125             
Val Ser Ser 
    130     

<210> 24
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 8-10

<400> 24
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Arg Ala Ser Gln Gly Leu Asp Ser Ser 
            20                  25                  30          
His Leu Ala Trp Tyr Arg Phe Lys Arg Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Thr Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 25
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 9-23

<400> 25
Gln Ala His Leu Phe Gln Ser Gly Ala Glu Leu Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Tyr Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Gln Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Leu Glu Leu Arg Ser Leu Arg Leu Asp Asp 
                85                  90                  95      
Thr Gly Ile Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Glu Arg Ala Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Ala Gly Thr Thr Val Ile 
        115                 120                 125             
Val Ser Ser 
    130     

<210> 26
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 9-23

<400> 26
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Val Leu Ser Cys Arg Ala Ser Glu Gly Leu Asp Ser Ser 
            20                  25                  30          
Gln Leu Ala Trp Tyr Arg Phe Lys Asp Gly Gln Ile Pro Arg Leu Val 
        35                  40                  45              
Leu Phe Gly Val Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Gly Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  
Arg Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Phe Gly Ala Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Arg Leu Asp Met Asn 
            100                 105             

<210> 27
<211> 131
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 10-7

<400> 27
Gln Gly Arg Phe Phe Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Arg Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Trp Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Arg Pro Glu Trp Leu Gly Val Ile Ser Pro His Phe Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Arg Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Ala Val Tyr Leu Glu Leu Gln Gly Leu Gln Pro Asp Asp 
                85                  90                  95      
Ser Gly Ile Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Asp Arg Ala Pro 
            100                 105                 110         
His Tyr Asn Tyr His Met Asp Val Trp Gly Gly Gly Thr Ala Val Ile 
        115                 120                 125             
Val Ser Ser 
    130     

<210> 28
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 10-7

<400> 28
Glu Val Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Ile Leu Ser Cys Arg Ala Ser Glu Gly Leu Asp Pro Thr 
            20                  25                  30          
His Leu Ala Trp Tyr Arg Phe Lys Arg Gly Gln Ile Pro Thr Leu Val 
        35                  40                  45              
Ile Phe Gly Thr Ser Asn Arg Ala Arg Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Glu Ala Asp Phe Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Tyr Gly Gly Thr Pro 
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Thr Leu Asp Lys Lys 
            100                 105             

<210> 29
<211> 123
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 8-52

<400> 29
Gln Leu Val Gln Trp Gly Gly Gly Val Lys Arg Pro Gly Ala Ser Val 
1               5                   10                  15      
Arg Ile Ser Cys Gln Cys Pro Glu Asp Thr Phe Thr Lys Tyr Tyr Ile 
            20                  25                  30          
His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Leu Gly Met 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Phe His Thr Ser Glu Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Met Thr Arg Asp Ile His Glu Thr Thr His His Met Val 
65                  70                  75                  80  
Leu Ser Gly Leu Gly Val Ala Asp Ser Gly Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Pro Leu Gly Glu Lys Ser Pro Ala Tyr Ser His His Met Asp Val 
            100                 105                 110         
Trp Gly Gly Gly Ala Thr Val Ile Val Ser Ser 
        115                 120             

<210> 30
<211> 111
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 8-52

<400> 30
Ala Val Val Leu Thr Gln Ser Pro Val Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Thr Ala Ile Leu Ser Cys Arg Ala Ser His Gly Leu Asp Thr Arg 
            20                  25                  30          
His Val Thr Trp Phe Gln Gln Lys Arg Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Ala Thr Tyr Arg Arg Ala Ser Gly Val Ser Asp Arg Phe Arg 
    50                  55                  60                  
Ala Thr Asp Ser Gly Ser Ala Thr Asp Phe Asn Leu Thr Ile Thr Ala 
65                  70                  75                  80  
Val Glu Pro Ala Asp Phe Ala Thr Tyr Phe Cys Gln Thr Tyr Gly Ala 
                85                  90                  95      
Ile Thr Pro Ile Thr Phe Gly Gly Gly Thr Lys Val Asp Leu Lys 
            100                 105                 110     

<210> 31
<211> 123
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 9-89

<400> 31
Gln Leu Val Gln Trp Gly Gly Gly Val Lys Arg Pro Gly Ala Ser Val 
1               5                   10                  15      
Arg Ile Ser Cys Gln Cys Pro Glu Asp Thr Phe Thr Lys Tyr Tyr Ile 
            20                  25                  30          
His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Leu Gly Met 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Phe His Thr Ser Glu Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Met Thr Arg Glu Ile His Glu Thr Thr His His Met Val 
65                  70                  75                  80  
Leu Ser Gly Leu Gly Val Gly Asp Ser Gly Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Pro Leu Gly Glu Lys Ser Pro Ala Tyr Ser His His Met Asp Val 
            100                 105                 110         
Trp Gly Gly Gly Ala Thr Val Ile Val Ser Ser 
        115                 120             

<210> 32
<211> 111
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 9-89

<400> 32
Ala Val Val Leu Thr Gln Ser Pro Val Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Ser Ala Val Leu Ser Cys Arg Ala Ser His Gly Leu Asp Thr Arg 
            20                  25                  30          
His Val Thr Trp Phe Gln Gln Lys Arg Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Ala Thr Ser Arg Arg Ala Ser Gly Val Ser Asp Arg Phe Arg 
    50                  55                  60                  
Ala Thr Asp Gly Gly Ser Ala Thr Asp Phe Asn Leu Thr Ile Thr Ala 
65                  70                  75                  80  
Val Glu Pro Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Gly Ala 
                85                  90                  95      
Ile Thr Pro Ile Thr Phe Gly Gly Gly Thr Lys Leu Asp Leu Lys 
            100                 105                 110     

<210> 33
<211> 126
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 9-71

<400> 33
Gln Leu Ala Gln Ser Gly Gly Gly Val Lys Lys Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Ile Ser Cys Val Thr Pro Glu Ser Thr Phe Thr Lys Tyr Trp Leu 
            20                  25                  30          
His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Leu Gly Val 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Met Phe Ala Asn Lys Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Leu Thr Arg Asp Ile His Thr Thr Thr His Tyr Met Glu 
65                  70                  75                  80  
Leu Arg Gly Leu Thr Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
                85                  90                  95      
Asp Ser Phe Gly Glu Thr Phe Arg His Ser Gly Asp Gln Pro Tyr Gln 
            100                 105                 110         
Met Asp Val Trp Gly Gly Gly Thr Asn Ile Val Val Ser Ser 
        115                 120                 125     

<210> 34
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 9-71

<400> 34
Glu Pro Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Phe Ser Val Asp 
            20                  25                  30          
His Leu Ala Trp Phe Gln Lys Arg Pro Gly Arg Pro Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Glu Thr Ser Arg Arg Ala Asn Gly Ser Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Ala Ser Gly Ala Glu Tyr Thr Leu Thr Ile Ser Asn Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Ile Thr 
                85                  90                  95      
Pro Leu Ile Phe Gly Gly Gly Thr Arg Val Asp Val Lys 
            100                 105                 

<210> 35
<211> 125
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 1-23

<400> 35
Gln Leu Val Gln Ser Gly Gly Gly Val Arg Arg Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Ile Ser Cys Glu Thr Pro Glu Tyr Thr Phe Thr Lys Tyr Trp Leu 
            20                  25                  30          
His Trp Leu Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met Gly Val 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Met Phe Ala Phe Glu Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Leu Thr Arg Asp Ile His Thr Thr Thr His Tyr Met Glu 
65                  70                  75                  80  
Leu Arg Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Ser Phe Gly Glu Thr Phe Arg Gly His Asp Gln Pro Tyr Gln Met 
            100                 105                 110         
Asp Val Trp Gly Gly Gly Thr Thr Val Val Val Ser Ser 
        115                 120                 125 

<210> 36
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 1-23

<400> 36
Glu Pro Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Gly Ala Thr Leu Ser Cys Arg Ala Arg Gln Gly Phe Ser Ala Asp 
            20                  25                  30          
His Val Ala Trp Phe Gln Lys Lys Pro Gly Arg Pro Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Glu Ala Ser Arg Arg Ala Ser Gly Thr Pro Glu Arg Phe Ser 
    50                  55                  60                  
Gly Gly Gly Ser Gly Pro Glu Tyr Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Ile Thr 
                85                  90                  95      
Pro Leu Val Phe Gly Gly Gly Thr Arg Val Asp Val Lys 
            100                 105                 

<210> 37
<211> 125
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 1-29

<400> 37
Gln Leu Val Gln Ser Gly Gly Gly Val Arg Arg Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Val Ser Cys Glu Thr Pro Glu Tyr Thr Phe Thr Lys Tyr Trp Leu 
            20                  25                  30          
His Trp Leu Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met Gly Val 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Met Phe Ala Phe Glu Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Leu Thr Arg Asp Ile His Thr Thr Thr His Tyr Met Glu 
65                  70                  75                  80  
Leu Arg Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      
Asp Ser Phe Gly Glu Thr Phe Arg Gly His Asp Gln Pro Tyr Gln Met 
            100                 105                 110         
Asp Leu Trp Gly Gly Gly Thr Thr Val Val Val Ser Ser 
        115                 120                 125 

<210> 38
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 1-29

<400> 38
Glu Pro Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Gly Val Thr Leu Ser Cys Arg Ala Arg Gln Gly Phe Ser Ala Asp 
            20                  25                  30          
His Val Ala Trp Phe Gln Lys Lys Pro Gly Arg Pro Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Glu Thr Ser Arg Arg Ala Ser Gly Thr Pro Glu Arg Phe Ser 
    50                  55                  60                  
Gly Gly Gly Ser Gly Pro Glu Tyr Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Ile Thr 
                85                  90                  95      
Pro Leu Val Phe Gly Gly Gly Thr Arg Val Asp Val Lys 
            100                 105                 

<210> 39
<211> 125
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 2-12

<400> 39
Gln Leu Val Gln Ser Gly Gly Gly Val Arg Arg Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Ile Ser Cys Glu Thr Pro Glu Asp Thr Phe Thr Lys Tyr Trp Leu 
            20                  25                  30          
His Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Val 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Met Phe Ala Phe Glu Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Leu Thr Arg Asp Ile His Thr Thr Thr His Phe Met Glu 
65                  70                  75                  80  
Leu Arg Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      
Asp Pro Phe Gly Glu Thr Phe Arg Gly His Asp Gln Pro Tyr Arg Met 
            100                 105                 110         
Asp Val Trp Gly Gly Gly Thr Thr Ile Val Val Ser Ser 
        115                 120                 125 

<210> 40
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 2-12

<400> 40
Glu Pro Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Gly Ala Thr Leu Ser Cys Arg Ala Arg Gln Gly Phe Ser Ala Asp 
            20                  25                  30          
His Val Ala Trp Phe Gln Lys Lys Pro Gly Arg Pro Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Glu Ala Ser Arg Arg Ala Ser Gly Thr Pro Glu Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Pro Glu Tyr Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  
Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Ile Thr 
                85                  90                  95      
Pro Leu Val Phe Gly Gly Gly Thr Arg Val Asp Val Lys 
            100                 105                 

<210> 41
<211> 125
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 2-21

<400> 41
Gln Leu Val Gln Ser Gly Gly Gly Val Lys Arg Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Ile Ser Cys Glu Thr Pro Glu Tyr Thr Phe Thr Lys Tyr Trp Leu 
            20                  25                  30          
His Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Val 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Met Phe Ala Phe Glu Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Leu Thr Arg Asp Ile His Thr Thr Thr His Tyr Met Glu 
65                  70                  75                  80  
Leu Gly Gly Leu Thr Leu Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      
Asp Pro Phe Gly Glu Thr Phe Arg Gly Arg Glu Gln Pro Tyr Gln Met 
            100                 105                 110         
Asp Val Trp Gly Gly Gly Thr Thr Ile Val Val Thr Ser 
        115                 120                 125 

<210> 42
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 2-21

<400> 42
Glu Ala Leu Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Gly Ala Thr Leu Ser Cys Arg Ala Arg Gln Gly Phe Ser Ala Asp 
            20                  25                  30          
His Val Ala Trp Phe Gln Lys Lys Pro Gly Arg Pro Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Glu Ala Ser Arg Arg Ala Ser Gly Thr Pro Glu Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Pro Glu Tyr Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Ile Thr 
                85                  90                  95      
Pro Leu Val Phe Gly Gly Gly Thr Arg Val Asp Val Lys 
            100                 105                 

<210> 43
<211> 125
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 3-07

<400> 43
Gln Leu Val Gln Ser Gly Gly Gly Val Arg Arg Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Ile Ser Cys Glu Thr Pro Glu Asp Thr Phe Thr Lys Tyr Trp Leu 
            20                  25                  30          
His Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Val 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Met Phe Ala Phe Glu Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Leu Thr Arg Asp Ile His Thr Thr Thr His Phe Met Glu 
65                  70                  75                  80  
Leu Gly Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      
Asp Pro Phe Gly Glu Thr Phe Arg Gly His Asp Gln Pro Tyr Arg Met 
            100                 105                 110         
Asp Val Trp Gly Gly Gly Thr Thr Ile Val Val Ser Ser 
        115                 120                 125 

<210> 44
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 3-07

<400> 44
Glu Pro Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Gly Ala Thr Leu Ser Cys Arg Ala Arg Gln Gly Phe Ser Ala Asp 
            20                  25                  30          
His Val Ala Trp Phe Gln Lys Lys Pro Gly Arg Pro Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Glu Ala Ser Arg Arg Ala Ser Gly Thr Pro Glu Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Pro Glu Tyr Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Ile Thr 
                85                  90                  95      
Pro Leu Val Phe Gly Gly Gly Thr Arg Val Asp Val Lys 
            100                 105                 

<210> 45
<211> 125
<212> PRT
<213> Homo sapiens


<220> 
<223> Heavy chain of antibody 3-78

<400> 45
Gln Leu Val Gln Ser Gly Gly Gly Val Arg Arg Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Ile Ser Cys Glu Thr Pro Glu Tyr Thr Phe Thr Lys Tyr Trp Leu 
            20                  25                  30          
His Trp Leu Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met Gly Val 
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Met Phe Ala Phe Glu Phe Arg Asp 
    50                  55                  60                  
Arg Leu Thr Leu Thr Arg Asp Ile His Thr Thr Thr His Tyr Met Glu 
65                  70                  75                  80  
Leu Gly Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      
Asp Pro Phe Gly Glu Thr Phe Arg Gly His Asp Gln Pro Tyr Gln Met 
            100                 105                 110         
Asp Val Trp Gly Gly Gly Thr Thr Ile Val Val Ser Ser 
        115                 120                 125 

<210> 46
<211> 109
<212> PRT
<213> Homo sapiens


<220> 
<223> Light chain of antibody 3-78

<400> 46
Glu Pro Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Arg Gln Gly Phe Ser Ala Asp 
            20                  25                  30          
His Val Ala Trp Phe Gln Lys Lys Pro Gly Arg Pro Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Glu Ala Ser Arg Arg Ala Ser Gly Thr Pro Glu Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Pro Glu Tyr Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Ser Tyr Gly Ser Ile Thr 
                85                  90                  95      
Pro Leu Val Phe Gly Gly Gly Thr Arg Val Asp Val Lys 
            100                 105                 

<210> 47
<211> 131
<212> PRT
<213> Homo sapiens


<220>
<221> SITE
<222> 2, 3, 4, 9, 11, 19, 39, 50, 61, 71, 84, 87, 90, 91, 93, 
94, 97, 101, 109, 110, 111, 116, 123, 126, 127, 131
<223> Xaa can indicate any amino acid or no amino acid

<400> 47
Gln Xaa Xaa Xaa Phe Gln Ser Gly Xaa Glu Xaa Lys Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Xaa Ile Ser Cys Arg Ala Asp Asp Asp Pro Tyr Thr Asp Asp 
            20                  25                  30          
Asp Thr Phe Thr Lys Tyr Xaa Thr His Trp Ile Arg Gln Ala Pro Gly 
        35                  40                  45              
Gln Xaa Pro Glu Trp Leu Gly Val Ile Ser Pro His Xaa Ala Arg Pro 
    50                  55                  60                  
Ile Tyr Ser Tyr Lys Phe Xaa Asp Arg Leu Thr Leu Thr Arg Asp Ser 
65                  70                  75                  80  
Ser Leu Thr Xaa Val Tyr Xaa Glu Leu Xaa Xaa Leu Xaa Xaa Asp Asp 
                85                  90                  95      
Xaa Gly Ile Tyr Xaa Cys Ala Arg Asp Pro Phe Gly Xaa Xaa Xaa Pro 
            100                 105                 110         
His Tyr Asn Xaa His Met Asp Val Trp Gly Xaa Gly Thr Xaa Xaa Ile 
        115                 120                 125             
Val Ser Xaa 
    130     

<210> 48
<211> 108
<212> PRT
<213> Homo sapiens


<220>
<221> SITE
<222> 2, 13, 20, 21, 24, 30, 31, 32, 33, 41, 46, 51, 52, 54, 
64, 66, 69, 70, 77, 78, 81, 92, 94, 104, 107, 108 
<223> Xaa can indicate any amino acid or no amino acid

<220>
<221> SITE
<222> 49
<223> Xaa can be Leu or Ile

<400> 48
Glu Xaa Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Xaa Ser Pro Gly 
1               5                   10                  15      
Asp Arg Val Xaa Xaa Ser Cys Xaa Ala Ser Glx Gly Leu Xaa Xaa Xaa 
            20                  25                  30          
Xaa Leu Ala Trp Tyr Arg Phe Lys Xaa Gly Gln Ile Pro Xaa Leu Val 
        35                  40                  45              
Xaa Phe Xaa Xaa Ser Xaa Arg Ala Arg Gly Thr Pro Asp Arg Phe Xaa  
    50                  55                  60                  
Gly Xaa Gly Ser Xaa Xaa Asp Phe Thr Leu Thr Ile Xaa Xaa Val Glx  
65                  70                  75                  80  
Xaa Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Xaa Gly Xaa Thr Pro  
                85                  90                  95      
Ile Thr Phe Gly Gly Gly Thr Xaa Leu Asp Xaa Xaa 
            100                 105         

<210> 49
<211> 126
<212> PRT
<213> Homo sapiens


<220>
<221> SITE
<222> 3, 5, 10, 11, 17, 18, 21, 22, 25, 31, 35, 41, 43, 46, 48, 
57, 58, 59, 60, 61, 68, 71, 74, 78, 80, 82, 85, 86, 87, 89, 90, 
91, 93, 98, 99, 102, 103, 104, 105, 106, 107, 108, 109, 110, 
111, 112, 115, 120, 121, 122, 123, 125 
<223> Xaa can indicate any amino acid or no amino acid

<220>
<221> SITE
<222> 32
<223> Xaa can be Leu or Ile

<400> 49
Gln Leu Xaa Gln Xaa Gly Gly Gly Val Xaa Xaa Pro Gly Ala Ser Val 
1               5                   10                  15      
Xaa Xaa Ser Cys Xaa Xaa Pro Glu Xaa Thr Phe Thr Lys Tyr Xaa Xaa  
            20                  25                  30          
His Trp Xaa Arg Gln Ala Pro Gly Xaa Gly Xaa Glu Trp Xaa Gly Xaa  
        35                  40                  45              
Val Ser Pro His Gly Gly Arg Pro Xaa Xaa Xaa Xaa Xaa Phe Arg Asp  
    50                  55                  60                  
Arg Leu Thr Xaa Thr Arg Xaa Ile His Xaa Thr Thr His Xaa Met Xaa  
65                  70                  75                  80  
Leu Xaa Gly Leu Xaa Xaa Xaa Asp Xaa Xaa Xaa Tyr Xaa Cys Ala Arg  
                85                  90                  95      
Asp Xaa Xaa Gly Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
            100                 105                 110         
Met Asp Xaa Trp Gly Gly Gly Xaa Xaa Xaa Xaa Val Xaa Ser 
        115                 120                 125 

<210> 50
<211> 111
<212> PRT
<213> Homo sapiens


<220>
<221> SITE
<222> 1, 2, 3, 9, 13, 18, 19, 20, 26, 27, 29, 30, 31, 32, 34, 
35, 39, 40, 41, 43, 44, 51, 52, 53, 57, 59, 60, 61, 64, 65, 66,
67, 68, 69, 71, 72, 73, 74, 75, 79, 80, 83, 84, 88, 90, 93, 96, 
101, 107, 108, 110
<223> Xaa can indicate any amino acid or no amino acid

<220>
<221> SITE
<222> 100
<223> Xaa can be Leu or Ile

<400> 50
Xaa Xaa Xaa Leu Thr Gln Ser Pro Xaa Thr Leu Ser Xaa Ser Pro Gly 
1               5                   10                  15      
Glu Xaa Xaa Xaa Leu Ser Cys Arg Ala Xaa Xaa Gly Xaa Xaa Xaa Xaa 
            20                  25                  30          
His Xaa Xaa Trp Phe Gln Xaa Xaa Xaa Gly Xaa Xaa Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Xaa Xaa Xaa Arg Arg Ala Xaa Gly Xaa Xaa Xaa Arg Phe Xaa 
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Leu Thr Ile Xaa Xaa 
65                  70                  75                  80  
Val Glu Xaa Xaa Asp Phe Ala Xaa Tyr Xaa Cys Gln Xaa Tyr Gly Xaa 
                85                  90                  95      
Ile Thr Pro Xaa Xaa Phe Gly Gly Gly Thr Xaa Xaa Asp Xaa Lys 
            100                 105                 110 

<210> 51
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> Loop D (aa 274-284) of HIV-1 gp120 (YU2 wild-type sequence)

<400> 51
Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile 
1               5                   10      

<210> 52
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> β23/V5 Loop (aa 458-471) of HIV-1 gp120 (YU2 wild-type sequence)

<400> 52
Gly Gly Lys Asp Thr Asn Gly Thr Glu Ile Phe Arg Pro Gly 
1               5                   10                  

<210> 53
<211> 6
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> V1 Loop (aa 159-164) of HIV-1 gp120 (YU2 wild-type sequence)

<400> 53
Phe Asn Ile Thr Thr Ser 
1               5       

<210> 54
<211> 19
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> V3 Loop (aa 299-321) of HIV-1 gp120 (YU2 wild-type sequence)

<400> 54
Asn Asn Thr Arg Lys Ser Ile Asn Ile Gly Pro Gly Arg Ala Leu Tyr 
1               5                   10                  15      
Thr Thr Gly 
            

<210> 55
<211> 13
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> CD4-binding Loop (aa 363-375) of HIV-1 gp120 (YU2 wild-type
      sequence)

<400> 55
Pro Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser 
1               5                   10              

<210> 56
<211> 9
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> β20/β21 Loop (aa 425-433) of HIV-1 gp120 (YU2 wild-type sequence)

<400> 56
Asn Met Trp Gln Glu Val Gly Lys Ala 
1               5                   

<210> 57
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> T278I/N279K mutant of Loop D from mouse 1021

<400> 57
Ser Glu Asn Phe Ile Lys Asn Ala Lys Thr Ile 
1               5                   10      

<210> 58
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> A281T mutant of Loop D from mouse 1021 and 1186

<400> 58
Ser Glu Asn Phe Thr Asn Asn Thr Lys Thr Ile 
1               5                   10      

<210> 59
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> A281D mutant of Loop D from mouse 1021, 1211 and 1087

<400> 59
Ser Glu Asn Phe Thr Asn Asn Asp Lys Thr Ile 
1               5                   10      

<210> 60
<211> 12
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459D/T462del/N463del/G471E mutant of β23/V5 Loop from mouse 1021

<400> 60
Gly Asp Lys Asp Gly Thr Glu Ile Phe Arg Pro Glu 
1               5                   10          

<210> 61
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459D/G471E mutant of β23/V5 Loop from mouse 1021

<400> 61
Gly Asp Lys Asp Thr Asn Gly Thr Glu Ile Phe Arg Pro Glu 
1               5                   10                  

<210> 62
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> K282E mutant of Loop D from mouse 1135 and 1140

<400> 62
Ser Glu Asn Phe Thr Asn Asn Ala Glu Thr Ile 
1               5                   10      

<210> 63
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459D/G464E mutant of β23/V5 Loop from mouse 1135, 1140 and 940

<400> 63
Gly Asp Lys Asp Thr Asn Glu Thr Glu Ile Phe Arg Pro Gly 
1               5                   10                  

<210> 64
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459D mutant of β23/V5 Loop from mouse 1140, 1130, 940, 1087,
      1186, 1214 and 1069

<400> 64
Gly Asp Lys Asp Thr Asn Gly Thr Glu Ile Phe Arg Pro Gly 
1               5                   10                  

<210> 65
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459E mutant of β23/V5 Loop from mouse 1211

<400> 65
Gly Glu Lys Asp Thr Asn Gly Thr Glu Ile Phe Arg Pro Gly 
1               5                   10                  

<210> 66
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> K282R mutant of Loop D from mouse 1211

<400> 66
Ser Glu Asn Phe Thr Asn Asn Ala Arg Thr Ile 
1               5                   10      

<210> 67
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> N280D mutant of Loop D from mouse 1050, 1130, 1161 and 1087

<400> 67
Ser Glu Asn Phe Thr Asn Asp Ala Lys Thr Ile 
1               5                   10      

<210> 68
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459V mutant of β23/V5 Loop from mouse 1050

<400> 68
Gly Val Lys Asp Thr Asn Gly Thr Glu Ile Phe Arg Pro Gly 
1               5                   10                  

<210> 69
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459V/K460E mutant of β23/V5 Loop from mouse 1050

<400> 69
Gly Val Glu Asp Thr Asn Gly Thr Glu Ile Phe Arg Pro Gly 
1               5                   10                  

<210> 70
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> N279S mutant of Loop D from mouse 1130

<400> 70
Ser Glu Asn Phe Thr Ser Asn Ala Lys Thr Ile 
1               5                   10      

<210> 71
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459D/T465N mutant of β23/V5 Loop from mouse 1130

<400> 71
Gly Asp Lys Asp Thr Asn Gly Asn Glu Ile Phe Arg Pro Gly 
1               5                   10                  

<210> 72
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459D/T465N/G471E mutant of β23/V5 Loop from mouse 1130

<400> 72
Gly Asp Lys Asp Thr Asn Gly Asn Glu Ile Phe Arg Pro Glu 
1               5                   10                  

<210> 73
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> N279Y mutant of Loop D from mouse 1210

<400> 73
Ser Glu Asn Phe Thr Tyr Asn Ala Lys Thr Ile 
1               5                   10      

<210> 74
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> T278A/A281T mutant of Loop D from mouse 1210

<400> 74
Ser Glu Asn Phe Ala Asn Asn Thr Lys Thr Ile 
1               5                   10      

<210> 75
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> N279K mutant of Loop D from mouse 940

<400> 75
Ser Glu Asn Phe Thr Lys Asn Ala Lys Thr Ile 
1               5                   10      

<210> 76
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> S274F mutant of Loop D from mouse 940 and 1087

<400> 76
Phe Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile 
1               5                   10      

<210> 77
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G459D/K460E mutant of β23/V5 Loop from mouse 1186

<400> 77
Gly Asp Glu Asp Thr Asn Gly Thr Glu Ile Phe Arg Pro Gly 
1               5                   10                  

<210> 78
<211> 11
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> S274Y mutant of Loop D from mouse 1214

<400> 78
Tyr Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile 
1               5                   10      

<210> 79
<211> 9
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> M426I mutant of β20/β21 Loop from mouse 1069

<400> 79
Asn Ile Trp Gln Glu Val Gly Lys Ala 
1               5                   

<210> 80
<211> 14
<212> PRT
<213> Human immunodeficiency virus 1


<220> 
<223> G471R mutant of β23/V5 Loop from mouse 1069

<400> 80
Gly Gly Lys Asp Thr Asn Gly Thr Glu Ile Phe Arg Pro Arg 
1               5                   10                  

