                         SEQUENCE LISTING

<110>  University of Maryland, Baltimore
       U.S. Department of Veterans Affairs
       The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
 
<120>  Broadly Neutralizing and Potent Antibodies Against HIV

<130>  UMB-069PCT1

<150>  62/940,572
<151>  2019-11-26

<160>  546   

<170>  PatentIn version 3.5

<210>  1
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Gly Leu Met Gln Ser Gly Ala Val Met Lys Asn Ser Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Gln Ala Asp Gly Tyr Asp Phe Ile Asp Tyr Val 
            20                  25                  30          


Ile His Trp Phe Arg Gln Arg Arg Gly Glu Gly Leu Glu Trp Leu Gly 
        35                  40                  45              


Trp Met Asn Pro Ser Gly Gly Gly Thr Asn Tyr Pro Arg Pro Phe Gln 
    50                  55                  60                  


Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Glu Thr Ala Tyr Leu 
65                  70                  75                  80  


Asp Val Arg Gly Leu Thr Tyr Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ala Asn Gly Ser Gly Arg Arg Arg Phe Glu Ser Val Asn 
            100                 105                 110         


Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr Gln Ile Thr Val Val Ser 
        115                 120                 125             


Pro Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        355                 360                 365             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  2
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Thr Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Gly 
65                  70                  75                  80  


His Tyr Phe Cys Trp Ala Phe Glu Asn Ile Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  3
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ser 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  4
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  5
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Lys Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Gln Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Arg Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Val His Ser Pro 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  6
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  7
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Ala Glu Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Gln Ala Tyr Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Val Tyr Gly Gln Val Asn Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Asp Ile Tyr Arg Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Val Arg Asp Leu Lys Thr Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Thr Gly Asp Gly Ser Arg Arg His Phe Asp Ser Ile Asn 
            100                 105                 110         


Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr Trp Ile Arg Val Ala Pro 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        355                 360                 365             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  8
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Cys Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Asn Ala Pro Lys Leu Leu Leu Tyr Asp Phe Asp 
        35                  40                  45              


Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly Ser Arg Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Phe Glu Ala Phe Gly Gly Gly Thr Lys Val 
                85                  90                  95      


Leu Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  9
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Asp Leu Val Gln Ser Gly Ala Val Met Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Arg Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asp Pro Pro Tyr Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Trp Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  10
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  11
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Pro Gly Tyr Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Trp Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  12
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Ser Ala Leu Thr Gln Pro Arg Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Ile Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  13
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Asn Ala Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Val Asp Tyr Phe 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met Gly 
        35                  40                  45              


Tyr Met Asp Pro Leu Asn Gly Arg Pro Asn Ile Ala Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Leu Ser Leu Ser Arg Asp Arg Ser Ser Glu Thr Ser Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Asn Gly Ser Gly Arg Arg Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Arg Val Ser Ile Phe Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  14
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Tyr Asp Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  15
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Ser Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Arg Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Ser Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  16
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Val Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  17
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Thr Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Ile Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Leu Gly 
        35                  40                  45              


Tyr Ile Asp Pro Met Asn Gly Arg Pro Asn Ile Ala Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Ile Glu Thr Ser Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Asn Gly Ser Gly Lys Arg Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Arg Val Ser Ile Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  18
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Arg Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Tyr Asp Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  19
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Thr Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Arg Thr Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Asn Gly Ser Gly Lys Arg Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Pro Val Thr Ile Ser Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  20
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Ser Ile Thr Gly Leu Gln Asp Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  21
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Val Asp Tyr Leu 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met Gly 
        35                  40                  45              


Tyr Met Asp Pro Met Asn Gly Arg Pro Asn Ile Ala Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Ile Glu Thr Ser Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Gly Gly Ser Gly Lys Leu Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Arg Val Ser Ile Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  22
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Tyr Asp Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  23
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Pro Gly Tyr Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Glu Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Trp Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Ile Thr Val His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  24
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Ala Leu Thr Gln Pro Arg Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Ile Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Ile Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  25
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asp Pro Ser Tyr Gly Gln Val Asn Ile Pro Arg Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Phe Arg Glu Thr Ala Tyr Leu 
65                  70                  75                  80  


Glu Leu Arg Gly Leu Gln Ser Asp Asp Lys Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser His Gly Ser Gly Arg Gln Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Asn Val Gln Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  26
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  27
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Leu Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asp Pro Ser Phe Gly Gln Met Asn Ile Pro Arg Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Met Tyr Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser His Gly Ser Gly Arg Leu Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val Gln Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  28
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  29
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Leu Met Asp Pro Ser Phe Gly Arg Met Asn Ile Pro Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Met Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Phe Arg Gly Leu Asn Phe Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser His Gly Ser Gly Arg Leu Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val Gln Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  30
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  31
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Ile Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Leu Met Asp Pro Thr Tyr Gly Arg Met Asn Ile Pro Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser His Gly Ser Gly Arg Leu Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val Gln Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  32
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  33
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Leu Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  34
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  35
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  35

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Thr Gly Tyr Lys Phe Met Asp Gln 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Met Asp Thr Glu Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Gly Glu Asn Tyr Pro Phe His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Arg Val Val Val Ser Ser Pro Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  36
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  37
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  37

His Ile Gln Leu Leu Gln Ser Gly Pro Gln Val Lys Lys Ser Gly Asp 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Asn Phe Val Asp Ser 
            20                  25                  30          


Arg Ile His Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu Gln Gly Gly Val Asn Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ile Arg Met Thr Arg Asp Thr Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Val Asp Leu Ser Gly Leu Thr Pro Ala Asp Thr Ala Tyr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Asp Gly Lys Ser Tyr Pro Phe His Phe Trp Gly His 
            100                 105                 110         


Gly Thr Arg Val Thr Val Phe Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  38
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Phe Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Thr Ile Thr Cys Ala Gly Gly Ser Val Ser Trp Phe His Phe 
            20                  25                  30          


Pro Pro Gly Lys Thr Pro Arg Leu Ile Ile Tyr Glu Ser Ser Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Gln Ser Gly Ser Thr 
    50                  55                  60                  


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ser Asp Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Phe Cys Ser Ile Leu Glu Phe Phe Gly Arg Gly Thr Leu Val Thr Val 
                85                  90                  95      


Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            100                 105                 110         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser 
        115                 120                 125             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
    130                 135                 140                 


Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
145                 150                 155                 160 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                165                 170                 175     


Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr 
            180                 185                 190         


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200             


<210>  39
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Val Arg Leu Val Gln Ser Gly Ala Gly Ala Arg Lys Thr Gly Ala 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ser Thr Ser Gly Tyr Thr Phe Thr Thr His 
            20                  25                  30          


His Gly His Phe Ile Asn Trp Val Arg Gln Ala Arg Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Trp Met Asn Pro Met Thr Gly Gln Met Asn Ile Glu 
    50                  55                  60                  


Gly Lys Phe Gln Gly Arg Val Thr Leu Thr Arg Asp Ile Tyr Ser Asp 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Met Thr Arg Leu Thr Thr Gly Asp Thr Gly Thr 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Asp Phe Gly Gln Asn Tyr Pro Phe His Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ser Leu Val Ile Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  40
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Asn Arg Tyr Leu Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu Ile Ile Tyr Asp Asp 
        35                  40                  45              


Asn Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Asp Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Thr Gly Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Trp Cys Ala Ser Tyr Glu Arg Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  41
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  41

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Thr Asp Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Gly Glu Asn Tyr Pro Phe His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Arg Val Val Val Ser Ser Pro Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  42
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  43
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  43

His Ile Gln Leu Leu Gln Ser Gly Pro Gln Val Lys Lys Ser Gly Asp 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Asn Phe Val Asp Ser 
            20                  25                  30          


Arg Ile His Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu His Gly Gly Val Asn Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ile Arg Met Thr Arg Asp Thr Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Val Asp Leu Ser Gly Leu Thr Pro Ala Asp Thr Ala Tyr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Asp Gly Lys Ser Tyr Pro Phe His Phe Trp Gly His 
            100                 105                 110         


Gly Thr Arg Val Thr Val Phe Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  44
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Phe Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Thr Ile Thr Cys Ala Gly Gly Ser Val Ser Trp Phe His Phe 
            20                  25                  30          


Pro Pro Gly Lys Thr Pro Arg Leu Ile Ile Tyr Glu Ser Ser Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Gln Ser Gly Ser Thr 
    50                  55                  60                  


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ser Asp Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Phe Cys Ser Ile Leu Glu Phe Phe Gly Arg Gly Thr Leu Val Thr Val 
                85                  90                  95      


Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            100                 105                 110         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser 
        115                 120                 125             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
    130                 135                 140                 


Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
145                 150                 155                 160 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                165                 170                 175     


Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr 
            180                 185                 190         


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200             


<210>  45
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  45

Arg Val Thr Leu Gln Gln Ser Gly Ala Ile Val Arg Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Phe Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile His Pro Arg Thr Gly Ala Val Lys Tyr Ala Pro Arg Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ser Met Thr Arg Asp Trp Ser Leu Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Thr Gly Leu Thr Leu Gly Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Phe Glu Ala Asp Ser Tyr Gly Ser Ser Tyr Pro Phe 
            100                 105                 110         


His His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  46
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  46

Ser Trp Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Met Ser Cys Thr Gly Phe Gly Asn Tyr Asn Pro Asp Ser 
            20                  25                  30          


Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Glu 
        35                  40                  45              


Asp Asn Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Ala Ser Arg 
    50                  55                  60                  


Leu Gly Ser Thr Ser Ser Leu Thr Ile Ser Asn Val Gln Ala Ala Asp 
65                  70                  75                  80  


Asp Ala His Tyr Val Cys Ala Ser Phe Glu Phe Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
            100                 105                 110         


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
        115                 120                 125             


Cys Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
    130                 135                 140                 


Ala Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser 
145                 150                 155                 160 


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
                165                 170                 175     


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His 
            180                 185                 190         


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205         


<210>  47
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  47

Arg Val Thr Leu Gln Gln Ser Gly Ala Thr Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Arg Ile His Pro Arg Thr Gly Ala Val Lys Tyr Ala Pro Ile Phe 
    50                  55                  60                  


Gln Gly Lys Val Ser Met Ser Arg Asp Leu Ser Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Thr Arg Leu Thr Leu Ala Asp Thr Ala Leu Phe Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Phe Glu Ala Asp Leu Ser Gly Pro Thr Tyr Pro Phe 
            100                 105                 110         


His His Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ala Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  48
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Trp Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Met Ser Cys Thr Gly Phe Gly Asn Tyr Asn Pro Asp Ser 
            20                  25                  30          


Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Glu 
        35                  40                  45              


Asp Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Ala Ser Arg 
    50                  55                  60                  


Leu Gly Ser Thr Ser Ser Leu Thr Ile Ser Asn Val Gln Ala Ala Asp 
65                  70                  75                  80  


Asp Ala His Tyr Val Cys Ala Ser Phe Glu Phe Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Ile Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
            100                 105                 110         


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
        115                 120                 125             


Cys Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
    130                 135                 140                 


Ala Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser 
145                 150                 155                 160 


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
                165                 170                 175     


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His 
            180                 185                 190         


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205         


<210>  49
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  49

Asn Val Gln Leu Met Gln Ser Gly Thr Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Glu Thr Ala Gly Phe Asn Phe Ile Asp Ser 
            20                  25                  30          


Val Ile His Trp Leu Arg Gln Ala Pro Gly Gly Gly Phe Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Arg Gly Ala Val Asn Tyr Pro Gln Phe Leu 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Asp Leu Ser Thr Asp Thr Val Tyr 
65                  70                  75                  80  


Met Val Leu Asn Gly Leu Thr Pro Asp Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Phe Arg Gly Gly Ser Pro Phe Gly Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  50
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Ser Ala Leu Ser Gln Pro Val Ser Val Ser Gly Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Ala Thr Thr Trp Tyr Gln Gln Leu 
            20                  25                  30          


Pro Gly Arg Pro Pro Lys Leu Ile Ile Tyr Asp Val Thr Asn Arg Pro 
        35                  40                  45              


Ser Gly Ile Ser Ser Arg Phe Ser Gly Ser Thr Ser Gly His Thr Ala 
    50                  55                  60                  


Ser Leu Thr Ile Ser Gly Leu Gln Val Asp Asp Glu Gly Leu Tyr His 
65                  70                  75                  80  


Cys Ala Ser Arg Glu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            100                 105                 110         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
        115                 120                 125             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
    130                 135                 140                 


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
145                 150                 155                 160 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                165                 170                 175     


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
            180                 185                 190         


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200         


<210>  51
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  51

Gln Val Arg Leu Val Gln Ser Gly Pro Gln Val Lys Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Leu Arg Leu Gly Pro Gly Glu Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu His Gly Ala Val Asn Tyr Glu Asn Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Asp Met Ser Arg Leu Thr Pro Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Ile Val Ala Asp Gly Trp Pro Tyr Gly His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  52
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  52

Ser Trp Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Ala Ile Ser Cys Ala Gly Gly Ser Val Ser Trp Tyr Gln Val 
            20                  25                  30          


Leu Pro Gly Arg Ala Pro Lys Leu Ile Ile Tyr Glu Gly Ala Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Ser Ala Arg Phe Ser Gly Ser Gln Ser Gly Asn Thr 
    50                  55                  60                  


Ala Tyr Leu Thr Ile Ser Asp Leu Gln Thr Glu Asp Glu Gly Ile Tyr 
65                  70                  75                  80  


Phe Cys Ser Ser Leu Gln Phe Phe Gly Gly Gly Thr Lys Leu Thr Val 
                85                  90                  95      


Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            100                 105                 110         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser 
        115                 120                 125             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
    130                 135                 140                 


Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
145                 150                 155                 160 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                165                 170                 175     


Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr 
            180                 185                 190         


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200             


<210>  53
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Val Arg Leu Gln Gln Ser Gly Val Val Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Phe Thr Phe Ile Asp His 
            20                  25                  30          


Ile Val His Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Arg Gly Ala Val Asp Tyr Ala Pro Gln Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Leu Thr Arg Asp Ile Tyr Ser Glu Thr Val Phe 
65                  70                  75                  80  


Ile Asp Val Ser Arg Leu Thr Ser Gly Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Cys Lys Ala Ala Ala Pro Glu Glu Ala Phe Pro Leu Gln Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Leu Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  54
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Leu His Pro Gly Arg Ala Pro Lys Leu Leu Ile Val Asp Asn Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Arg Thr Phe Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  55
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  55

Gln Val Arg Leu Gln Gln Ser Gly Val Val Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Glu Thr Ser Gly Phe Lys Phe Ile Asp His 
            20                  25                  30          


Ile Val Asn Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Gly Gly Val Ala Asp Tyr Ala Pro Gln His 
    50                  55                  60                  


Arg Gly Arg Ile Ser Leu Thr Arg Asp Ile Tyr Thr Glu Thr Val Phe 
65                  70                  75                  80  


Ile Asp Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Cys Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Leu Ile Val Ser Pro Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  56
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Ile Gln Pro Gly Arg Leu Pro Lys Leu Leu Ile Val Asp Asn Asn 
        35                  40                  45              


Arg Arg Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  57
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  57

Gln Val Arg Leu Val Gln Ser Gly Pro Val Met Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Phe Ala Phe Leu Asp His 
            20                  25                  30          


Ile Val His Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Val Lys Thr Ile Gly Gly Val Val Asp Tyr Ala Pro His Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Val Thr Arg Asp Val Phe Ser Glu Thr Val Phe 
65                  70                  75                  80  


Leu Asp Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ser Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  58
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Leu His Pro Gly Arg Ala Pro Lys Leu Leu Ile Leu Asp Asn Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Asp Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Arg Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  59
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Val Arg Leu Val Gln Ser Gly Pro Val Val Arg Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Phe Ala Phe Leu Asp His 
            20                  25                  30          


Ile Val His Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Val Lys Thr Ile Gly Gly Val Val Asp Tyr Ala Pro His Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Val Thr Arg Asp Val Phe Ser Glu Ile Val Phe 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ser Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  60
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Leu His Pro Gly Arg Ala Pro Lys Leu Leu Ile Val Asp Asn Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Asp Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Arg Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  61
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Val Gln Leu Val Gln Ser Gly Ala Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Thr Ser Gly Phe Lys Phe Thr Glu Tyr 
            20                  25                  30          


Phe Ile His Phe Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Leu Arg Gly Ala Val Asn Tyr Pro Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Ile Tyr Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Gly Leu Thr Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Asn Glu Ala Phe Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  62
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  62

Ser Trp Ala Gln Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Ile Val Ser Asp Ala Trp Tyr Gln 
            20                  25                  30          


Gln Tyr Pro Gly Arg Pro Pro Arg Leu Ile Leu Tyr Asp Gly Asp Lys 
        35                  40                  45              


Arg Pro Ser Gly Val Ser Pro Arg Phe Ser Ala Ser Arg Ala Gly Lys 
    50                  55                  60                  


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Tyr 
65                  70                  75                  80  


Tyr His Cys Ala Ser Arg Glu Phe Phe Gly Gly Val Thr Lys Leu Thr 
                85                  90                  95      


Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
            100                 105                 110         


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val 
        115                 120                 125             


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly 
    130                 135                 140                 


Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser 
145                 150                 155                 160 


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
                165                 170                 175     


Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser 
            180                 185                 190         


Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 


<210>  63
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  63

Gln Val Arg Leu Gln Gln Ser Gly Val Val Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Glu Thr Ser Gly Phe Lys Phe Ile Asp His 
            20                  25                  30          


Ile Val Asn Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Gly Gly Val Ala Asp Tyr Ala Pro Gln His 
    50                  55                  60                  


Arg Gly Arg Ile Ser Leu Thr Arg Asp Ile Tyr Thr Glu Thr Val Phe 
65                  70                  75                  80  


Ile Asp Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Cys Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Leu Ile Val Ser Pro Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  64
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Ile Gln Pro Gly Arg Leu Pro Lys Leu Leu Ile Val Asp Asn Asp 
        35                  40                  45              


Arg Arg Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  65
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  65

Gln Val Arg Leu Val Gln Ser Gly Pro Val Met Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Phe Ala Phe Leu Asp His 
            20                  25                  30          


Ile Val His Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Val Lys Thr Ile Gly Gly Val Val Asp Tyr Ala Pro His Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Val Thr Arg Asp Val Phe Ser Glu Thr Val Phe 
65                  70                  75                  80  


Leu Asp Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ser Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  66
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Leu His Pro Gly Arg Ala Pro Lys Leu Leu Ile Leu Asp Asn Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Asp Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Arg Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  67
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  67

His Val Gln Leu Arg Gln Ser Gly Thr Glu Ala Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Glu Thr Ala Gly Phe Asn Phe Ile Asp Ser 
            20                  25                  30          


Val Ile His Trp Leu Arg Gln Ala Pro Gly Gly Gly Phe Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Arg Gly Gly Val Asn Tyr Pro His Tyr Leu 
    50                  55                  60                  


Gln Gly Arg Ile Ser Met Thr Arg Asp Leu Ser Ser Asp Thr Val Tyr 
65                  70                  75                  80  


Met Val Leu Asn Arg Leu Thr Pro Ala Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Phe Gly Gly Ser Ser Pro Phe Gly Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  68
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  68

Gln Ser Ala Leu Ser Gln Pro Val Ser Val Ser Gly Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Glu Ala Thr Thr Trp Tyr Gln Gln Leu 
            20                  25                  30          


Pro Gly Lys Pro Pro Lys Leu Ile Ile Tyr Asp Val Thr Asn Arg Pro 
        35                  40                  45              


Ser Gly Ile Ser Ser Arg Phe Ser Gly Ser Met Ser Gly Arg Thr Ala 
    50                  55                  60                  


Ser Leu Thr Ile Ser Gly Leu Gln Val Asp Asp Glu Gly Leu Tyr His 
65                  70                  75                  80  


Cys Ala Ser Arg Glu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            100                 105                 110         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
        115                 120                 125             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
    130                 135                 140                 


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
145                 150                 155                 160 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                165                 170                 175     


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
            180                 185                 190         


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200         


<210>  69
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  69

His Val Gln Leu Met Gln Ser Gly Thr Gln Ala Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Glu Thr Ala Gly Phe Lys Phe Ile Asp Ser 
            20                  25                  30          


Val Ile His Trp Leu Arg Gln Ala Pro Gly Gly Gly Phe Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Gly Gly Ala Val Asn Tyr Pro Pro Tyr Leu 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Arg Asp Leu Ser Thr Asp Thr Ile Tyr 
65                  70                  75                  80  


Met Val Leu Asn Gly Leu Thr Pro Ala Asp Thr Gly Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Phe Gly Gly Gly Ser Pro Phe Gly Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  70
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Ser Ala Leu Ser Gln Pro Val Ser Val Ser Gly Ser Pro Gly Asp 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Phe Gly Ala Thr Thr Trp Tyr Gln Gln Leu 
            20                  25                  30          


Pro Gly Arg Pro Pro Lys Leu Ile Ile Tyr Asp Val Thr Asn Arg Pro 
        35                  40                  45              


Ser Gly Ile Ser Gly Arg Phe Ser Gly Ser Met Ser Gly Gln Lys Ala 
    50                  55                  60                  


Ser Leu Thr Ile Ser Gly Leu Gln Val Asp Asp Glu Gly Leu Tyr His 
65                  70                  75                  80  


Cys Ala Ser Arg Glu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            100                 105                 110         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
        115                 120                 125             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
    130                 135                 140                 


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
145                 150                 155                 160 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                165                 170                 175     


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
            180                 185                 190         


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200         


<210>  71
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  71

His Val Gln Leu Arg Gln Ser Gly Thr Glu Ala Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Glu Thr Ala Gly Phe Asn Phe Ile Asp Ser 
            20                  25                  30          


Val Ile His Trp Leu Arg Gln Ala Pro Gly Gly Gly Phe Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Arg Gly Gly Val Asn Tyr Pro His Tyr Leu 
    50                  55                  60                  


Gln Gly Arg Ile Ser Met Thr Arg Asp Leu Ser Ser Asp Thr Val Tyr 
65                  70                  75                  80  


Met Val Leu Asn Arg Leu Thr Pro Asp Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Phe Gly Gly Ser Ser Pro Phe Gly Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  72
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Ser Ala Leu Ser Gln Pro Val Ser Val Ser Gly Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Glu Ala Thr Thr Trp Tyr Gln Gln Leu 
            20                  25                  30          


Pro Gly Arg Ser Pro Lys Leu Ile Ile Tyr Asp Val Thr Asn Arg Pro 
        35                  40                  45              


Ser Gly Ile Ser Ser Arg Phe Ser Gly Ser Met Ser Gly Arg Thr Ala 
    50                  55                  60                  


Ser Leu Thr Ile Ser Gly Leu Gln Val Asp Asp Glu Gly Leu Tyr His 
65                  70                  75                  80  


Cys Ala Ser Arg Glu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            100                 105                 110         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
        115                 120                 125             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
    130                 135                 140                 


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
145                 150                 155                 160 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                165                 170                 175     


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
            180                 185                 190         


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200         


<210>  73
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  73

Arg Val Thr Leu Gln Gln Ser Gly Ala Thr Val Arg Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Glu Thr Ser Gly Phe Thr Phe Ile Lys Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Arg Ile His Pro Arg Thr Gly Ala Val Lys Phe Ala Pro Ile Phe 
    50                  55                  60                  


Gln Gly Lys Phe Ser Met Ser Arg Asp Leu Ser Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Thr Arg Leu Thr Leu Ala Asp Thr Ala Leu Phe Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Phe Glu Ala Asp Leu Tyr Gly Pro Thr Tyr Pro Phe 
            100                 105                 110         


His His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ala Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  74
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  74

Ser Trp Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Met Ser Cys Thr Gly Phe Gly Ser Tyr Asn Pro Asp Ser 
            20                  25                  30          


Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
        35                  40                  45              


Asp Asn Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Ala Ser Arg 
    50                  55                  60                  


Leu Gly Ser Thr Ser Ser Leu Thr Ile Ser Asn Val Gln Ala Ala Asp 
65                  70                  75                  80  


Asp Ala His Tyr Val Cys Ala Ser Phe Glu Phe Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
            100                 105                 110         


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
        115                 120                 125             


Cys Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
    130                 135                 140                 


Ala Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser 
145                 150                 155                 160 


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
                165                 170                 175     


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His 
            180                 185                 190         


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205         


<210>  75
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  75

His Ile Gln Leu Leu Gln Ser Gly Pro Gln Val Lys Lys Ser Gly Asp 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Asn Phe Val Asp Ser 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu Gln Gly Gly Val Asn Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ile Arg Met Thr Arg Asp Thr Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Val Asp Leu Ser Gly Leu Thr Pro Ala Asp Thr Ala Tyr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Asp Gly Asn Ser Tyr Pro Phe His Phe Trp Gly His 
            100                 105                 110         


Gly Thr Arg Val Thr Val Phe Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  76
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  76

Arg Phe Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Thr Ile Thr Cys Ala Gly Gly Ser Val Ser Trp Phe His Phe 
            20                  25                  30          


Pro Pro Gly Lys Thr Pro Arg Leu Ile Ile Tyr Glu Ser Ser Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Gln Ser Gly Ser Thr 
    50                  55                  60                  


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ser Asp Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Phe Cys Ser Ile Leu Glu Phe Phe Gly Arg Gly Thr Leu Leu Thr Val 
                85                  90                  95      


Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            100                 105                 110         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser 
        115                 120                 125             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
    130                 135                 140                 


Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
145                 150                 155                 160 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                165                 170                 175     


Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr 
            180                 185                 190         


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200             


<210>  77
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  77
gcgggactga tgcagtctgg ggctgtgatg aagaattcgg gggcctcagt gagggtctct       60

tgtcaggctg atggatacga cttcattgac tatgtcattc actggtttcg acaaagacgt      120

ggagaaggtc ttgagtggct gggatggatg aatccctcgg gaggcggcac aaactatccg      180

cgaccatttc agggcaaagt caccatgacc agggacacgt ccaccgagac agcctattta      240

gatgtcagag gacttacata tgacgacacg gccgtctatt attgtgtgag agacagggcc      300

aacggttcgg gaagaagacg ttttgagtcg gtgaattggt tcctggatct gtggggccgc      360

ggcacccaaa taacagtcgt ctcgccctcc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg      960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1080

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1374


<210>  78
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  78
cagtctgccc taactcagcc tcgctcagtg tccgcatctc ctggtcagtc agtcaccatc       60

tcctgcactg gaacacacaa ttatgtgtcc tggtgtcaac agaaaccggg ccaagccccc      120

aaattattaa tttacgattt caataaacgg ccctcagggg tctctgatcg cttctctggc      180

tccacgtctg gcaacacggc ctccctgacc atctctggac tccaggctga cgatgagggt      240

cattattttt gttgggcgtt tgaaaatatc ggcggaggga ccaagctgac cgtcctgcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  79
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  79
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc atcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  80
<211>  609
<212>  DNA
<213>  Homo sapiens

<400>  80
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  81
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  81
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatacaa atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ttgagtggat ggggtggatt aatccaatgg gcggacaagt aaacattcca      180

tggcagtttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccctctatt attgcgtgag agatcgaagt      300

aatggatcgg gaaggcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgcggtca ctgttcattc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  82
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  82
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  83
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  83
tcggcggaat tggtgcaatc tggggctgtg gtgaagaagc ctgggacctc cgtgaaggtc       60

tcttgtcagg cttatggata cacttttacc gactacctta ttcattggct tcgacaggcc      120

cctggacaag gacttgaatg gatgggatgg atgaatcctg tttatggaca agtaaattat      180

gcccaaaact ttcagggcag ggtctccatg accagggaca tttacaggga aacagcattt      240

ctagaggtgc gcgacctgaa gactgacgac acaggcactt attattgtgt gagagacaca      300

ggcgacggtt cgcggagaca ctttgactcc atcaattggt ttctcgatct ttggggccgc      360

gggacatgga taagggtcgc cccagcctcc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg      960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1080

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1374


<210>  84
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  84
cagtgtgtct tgactcagcc tcgctcagtg tccggatctc ctggacaatc agtcaccatc       60

tcctgcactg gaactcacaa ttatgtctcc tggtgtcaac accacccagg caacgccccc      120

aaattattac tttatgattt cgacaagcgg ccctcaggaa tctctgatcg cttctctggc      180

tctaggtctg gcaacacggc ctccctgacc atctctggcc tccagcctga ggatgaggcc      240

gattactttt gttgggcctt tgaagccttt ggcggaggga ccaaggtgct cgtccttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  85
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  85
gcggacttgg tgcagtctgg ggctgtgatg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc gaggatacac attcactgac tacgtcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggtggatt gatccacctt atggacaagt aaatattcca      180

tggaattttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

aatggatggg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcactc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  86
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  86
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagagccccc      120

aagttattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctaacc atcagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac tgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  87
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  87
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc aaggatacac attcactgac tacgtcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggtggatt aatccaggtt atggacaagt aaatattcca      180

tggaactttc agggcagggt ctccatgacc cgagacacgt ccatcgaaac agcatttctg      240

gacttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

aatggatggg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcactc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  88
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  88
cagtctgccc tgactcagcc tcgctcaatg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcagtggac tccaggatga cgatgacgcc      240

gaatacattt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  89
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  89
gcggacttgg tgcagtctgg ggctgtggtg aaaaatgctg gggcctcagt gagggtctcc       60

tgtgaggctt atggatacac attcgtggac tacttcattc attgggtccg acaggcccct      120

ggacaaggct ttgaatggat gggatacatg gatcccttga acgggcgccc aaacattgcg      180

cgaaaatttc agggcaggct ctccctgagt cgagataggt ccagcgaaac ttcatttctg      240

gacttaagtg gactgaggtc tgacgactcg gccgtctatt attgtgtgag agacaagagt      300

aatggatcgg gcagacggtt tgactcgtct aattggtttc tcgatctgtg gggccgtgga      360

acccgggtca gtattttctc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  90
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  90
cagtctgccc tgactcagcc tcgctcagtg tccgcaactc ctggacagtc agtcaccatc       60

tcctgcactg gaacccacaa ttatgtctct tggtgtcaac aacatccagg cagagccccc      120

aaattactaa tttatgactt caataagagg ccctcagggg tcccggatcg cttctctggc      180

tccggatctg gcggcacggc ctccctaacc atcactggac tccaggatga cgatgaagcg      240

gactattttt gttgggccta tgatgctttt ggcggaggga ccaagttgac cgtcctgcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  91
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  91
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagggtctcc       60

tgtgaggctt atggatacac attcagtgac tacatcattc attggattcg acgggcccct      120

ggacgaggcc ttgaatggat gggatggatg aatccgatgg gcggacaagt gaatattccg      180

tggaactttc aggggagagt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactgaggtc tgacgacacg gccgtctatt actgtgtgag agatcgcagc      300

aatggatcgg gcaagcgatt tgagtcctcc aattggttcc tcgatctgtg gggccgcggg      360

accgcggtca ctatttcctc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  92
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  92
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtttct tggtgtcaac atcacccagg cagagccccc      120

aagttattaa tttatgactt caataagaga ccctcaggtg tccctgatcg tttctctggc      180

tccgggtctg gcggcacggc ctccctaacc atcactggac tccaggatga cgatgaggct      240

gaatattttt gttgggcgta tgaagttttt ggcggaggga ccaagttgac cgtgcttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  93
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  93
gcggacttgg tgcagtctgg ggctgtggtg aagacgcctg gggcctcagt gagggtctcc       60

tgtgaggctt atggatacac attcattgac tacatcattc attgggtccg acaggcccct      120

ggacaaggtt ttgaatggct gggatacatc gatcctatga acgggcgccc aaacattgcg      180

cgaaaatttc agggcaggct ctccctgagc cgggatacgt ccatcgaaac atcatttctg      240

gacttaagtg gactgaggtc tgacgactcg gccgtctatt attgtgtgag agacaagagt      300

aatggatcgg gcaaacgatt tgactcctct aattggtttc tcgatctgtg gggccgtgga      360

acgcgggtca gcatttcttc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  94
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  94
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc agtcaccatc       60

tcctgcactg gaacccacaa ttatgtctct tggtgtcaac aacatccagg cagagccccc      120

aaattactaa tttatgactt caataagagg ccctcagggg tcccggatcg cttctctggc      180

tccggatctg gcggcacggc ctccctaacc atcactagac tccaggatga cgatgacgct      240

gactattttt gttgggcgta tgatgctttt ggcggaggga ccaagttgac cgtcctgcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  95
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  95
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggcctcagt gagggtctcc       60

tgtgaggctt atggatacac attcactgac tacatcattc attggattcg acaggcccct      120

ggacaaggcc ttgaatggat gggatggatg aatcctatgg gcgggcgcac aaatattccg      180

tggaaatttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagtg gactaacgtc tgacgacacg gccgtctatt attgcgtgag agacaagagt      300

aatggatcgg gcaaacgatt tgactcctct aattggttcc tcgatctgtg gggccgcgga      360

accccggtca ctatttcctc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  96
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  96
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac aacacccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctaagt atcactggac tccaggatga cgatgaagct      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgtccttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  97
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  97
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggcctcagt gcgggtctcc       60

tgtgaggctt atggatatac attcgttgac tacctcattc attgggtccg acaggccccc      120

ggacaaggtt ttgaatggat gggatacatg gatcctatga acgggcgccc aaatattgcg      180

cgaaaatttc agggcaggct ctccctgagc cgagatacgt ccatcgaaac atcatttctg      240

gacttaagtg gactgaggtc tgacgactcg gccgtctatt attgtgtgag agacaagagt      300

ggtggatcgg gcaaactatt tgactcctct aattggtttc tcgatctgtg gggccgtgga      360

acccgggtca gcatttcttc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  98
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  98
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc agtcaccatc       60

tcctgcaccg gaactcacaa ttatgtctct tggtgtcaac aacatccagg cagagccccc      120

aaattactaa tttatgactt caataagagg ccctcagggg tcccggatcg cttctctggc      180

tccggatctg gcggcacggc ctccctaacc atcactggac tccaggatga cgatgacgct      240

gattattttt gttgggcgta tgatgctttt ggcggaggga ccaagttgac cgtcctgcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  99
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  99
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc aaggatacac attcactgac tacgtcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggtggatt aatccaggtt atggacaagt aaatattcca      180

tggaactttc agggcagggt ctccatgacc cgagacacgt ccatcgaaac agcttttctg      240

gagttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

aatggatggg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtgatta ctgttcactc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  100
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  100
cagtctgccc tgactcagcc tcgctcaatg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatacattt gttgggcata tgaagctttc ggcggaggga ccaagttgac catacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  101
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  101
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc agggatatac attcaccgac tacgtcattc attggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggtggatg gatccaagtt atggacaagt caatattcca      180

cggaactttc agggcagggt ctccatgacc cgggacacgt tcagggaaac agcatatctg      240

gaattaagag gtctacagtc tgacgacaag ggcctctatt attgtgtgag agatcgaagt      300

cacggatcgg gaaggcaatt cgagtcctcc aactggttcc tcgatctgtg gggccgcggc      360

actgtggtca atgttcagtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  102
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  102
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacctccc      120

aaattattaa tttatgactt caataagagg gcttcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc attagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  103
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  103
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcact gagaatctcc       60

tgtgaggctc aaggatacac attcactgac tacgtcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat gggatggatg gatccaagtt ttggacaaat gaacattcca      180

cggaactttc agggcagggt ctccatgacc cgtgacatgt acatcgaaac agcatttctg      240

gacttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

catggatcgg gaaggctatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcagtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  104
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  104
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacctccc      120

aaattattaa tttatgactt caataagagg gcttcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc attagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  105
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  105
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc aaggatacag attcactgac tacgtcattc attggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggttgatg gatccaagtt ttggacgaat gaatattcca      180

cggaaatttc agggcagggt ctccatgacc cgggacacgt ccatggaaac agcatttctg      240

gacttcagag gtctaaattt tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

catggatcgg gaagactatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcagtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  106
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  106
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacctccc      120

aaattattaa tttatgactt caataagagg gcatcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcagtggac tccaagatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  107
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  107
ccggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatttcc       60

tgtgaggctc aaggatacac attcattgac tacgtcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggttgatg gatccaactt atggacgaat gaatattcca      180

cggaagtttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gtctaaaatc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

catggatcgg gaaggctatt cgagtcctcc aactggttcc tggatctgtg gggccgcggc      360

actgtggtca ctgttcagtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  108
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  108
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacctccc      120

aaattattaa tttatgactt caataagagg gcttcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcagtggac tccaagatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  109
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  109
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatacag atttcttgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat gggatggatg aatccaatgg gcggacaagt aaacattcca      180

tggaactttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggg      360

actgcggtca ctattcattc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  110
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  110
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  111
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  111
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgactggata taaattcatg gaccaactca taaactgggt gcggcaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaatccaa catatggaca agtaaattat      180

tcatggagat ttgaaggaag ggtcaccatg accagggaca tggacaccga gacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgc gagggggccc      300

tctggggaaa attatccttt tcactattgg ggccagggtg tccgagtggt cgtctcgtca      360

ccctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  112
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  112
gcatctgccc tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacgtaca tttgcaatac atatgaattc tttggcggag ggaccagatt gaccgtccta      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  113
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  113
cacattcagt tgctacagtc ggggcctcaa gttaagaagt ctggggacac agtgagaatc       60

tcctgtgaga cctctggata taacttcgtc gactcccgta tccactgggt ccgacagacc      120

ccggaaaaac gtctcagatg gatgggctgg atcaatcctc tccaaggtgg tgtgaattac      180

gcgccggaat ttcagggcag aatcaggatg accagggaca catttataga cacagtttac      240

gtggacctga gcggactgac accggccgac acggcctatt attactgcgc gcgagggatc      300

gatggcaagt cttacccctt tcatttctgg ggccacggaa cccgggtcac cgtcttctcg      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  114
<211>  609
<212>  DNA
<213>  Homo sapiens

<400>  114
cgatttgccc tgactcaacc tgcctccgtg tctgggtctc ctggacagac gatcaccata       60

acctgcgctg gaggcagcgt ctcctggttt catttccctc caggcaaaac ccccagactc      120

attatttatg agtcttctaa gcgaccctct ggggtctctc ctcgattctc tgggtcccag      180

tctggcagca cggcctccct tataatttct ggcctccagt ctgatgacga agggacatac      240

ttctgttcta ttcttgaatt tttcggcaga gggactcttg tcaccgtcct gagtcagccc      300

aaggctgccc cctcggtcac tctgttccca ccctcctctg aggagcttca agccaacaag      360

gccacactgg tgtgtctcgt aagtgacttc tacccgggag ccgtgacagt ggcctggaag      420

gcagatggca gccccgtcaa ggtgggagtg gagaccacca aaccctccaa acaaagcaac      480

aacaagtatg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga      540

agctacagct gccgggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctgca      600

gaatgctct                                                              609


<210>  115
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  115
caggtgcgct tggtgcagtc tggggctggg gcgaggaaga ctggggcctc aatgaaactt       60

tcctgctcga cctctggata caccttcacc actcatcacg gccacttcat aaattgggtg      120

cgacaggccc gtggacaagg gcttgagtgg atggggtgga tgaatcccat gactgggcag      180

atgaatattg aggggaaatt tcagggcaga gtcaccctca ctcgagacat atacagtgac      240

acggcttaca tggaaatgac cagactgaca actggcgaca cgggcactta ttactgtgcg      300

cgaggcgatt tcggacagaa ttatcccttt cattattggg gccagggaag cctggtcatc      360

gtctcctcgg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210>  116
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  116
ctgtctgccc tgactcagcc tgcctccgtg tctgggtctc ctgggcagtc ggtcaccatc       60

tcctgctctg gaacgaaccg ttaccttgtc tcctggtatc aacaacaccc tgacaaagcc      120

cccaaactca tcatttatga cgacaataag cggccctcag gaatttctga tcgcttctca      180

gcctccaggc ctgacgacac ggcctccctg acaatctctg gactccagac tggggacgag      240

gctacttatt ggtgtgcctc atatgaacgt tttggcggcg ggacgaggct gaccgtcctt      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  117
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  117
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accagggaca tgtacaccga cacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgc gagggggccc      300

tctggggaaa attatccttt tcactattgg ggccagggtg tccgagtggt cgtctcgtca      360

ccctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  118
<211>  609
<212>  DNA
<213>  Homo sapiens

<400>  118
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  119
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  119
cacattcagt tgctacagtc ggggcctcaa gttaagaagt ctggggacac agtgagaatc       60

tcctgtgaga cctctggata taacttcgtc gactcccgta tccactgggt ccgacagacc      120

ccggaaaaac gtctcagatg gatgggctgg atcaatcctc tccacggtgg tgtgaattac      180

gcgccggaat ttcagggcag aatcaggatg accagggaca catttataga cacagtttac      240

gtggacctga gcggactgac accggccgac acggcctatt attactgcgc gcgagggatc      300

gatggcaagt cttacccctt tcatttctgg ggccacggaa cccgggtcac cgtcttctcg      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  120
<211>  609
<212>  DNA
<213>  Homo sapiens

<400>  120
cgatttgccc tgactcaacc tgcctccgtg tctgggtctc ctggacagac gatcaccata       60

acctgcgctg gaggcagcgt ctcctggttt catttccctc caggcaaaac ccccagactc      120

attatttatg agtcttctaa gcgaccctct ggggtctctc ctcgattctc tgggtcccag      180

tctggcagca cggcctccct cataatttct ggcctccagt ctgatgacga agggacatac      240

ttctgttcta ttcttgaatt tttcggcaga gggactcttg tcaccgtcct gagtcagccc      300

aaggctgccc cctcggtcac tctgttccca ccctcctctg aggagcttca agccaacaag      360

gccacactgg tgtgtctcgt aagtgacttc tacccgggag ccgtgacagt ggcctggaag      420

gcagatggca gccccgtcaa ggtgggagtg gagaccacca aaccctccaa acaaagcaac      480

aacaagtatg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga      540

agctacagct gccgggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctgca      600

gaatgctct                                                              609


<210>  121
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  121
cgtgttacat tacaacaatc tggggctata gtgaggcagc ctggggcctc agtgaccgtc       60

tcctgcgaga cttctggata tactttcacc aagtatttca tctactgggt gcgacaggcc      120

cctggacagg gtcttgagtg gctgggcaga atacaccccc gaaccggtgc cgtgaagtat      180

gcaccgagat ttcagggtag actgtccatg accagagact ggtcactcga cacagcctac      240

ctcggattga ccggactgac actcggcgac acggctctat atttctgtgc gaggggggcc      300

tttgaggcag attcatatgg gtcaagttat ccctttcacc actggggcca gggaacccta      360

gtcaccgtct ccgcggcctc caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1365


<210>  122
<211>  621
<212>  DNA
<213>  Homo sapiens

<400>  122
tcctgggccc tgactcaacc cgcctccgtg tctgcgtctc ctgggcagtc ggtcaccatg       60

tcctgcactg gattcggaaa ttataaccct gactcctggt accaacaata cccaggcaaa      120

gcccccaaac tcatcattta tgaagacaat aaaagaccct cgggggtctc tgatcgcttc      180

tctgcctcca gacttggcag cacgtcttcc ctgacaatct ctaacgtcca ggctgcggac      240

gacgcccatt atgtctgcgc ctcctttgaa tttttcggcg gagggaccaa gctgaccgtc      300

ctgagtcagc ccaaggctgc cccctcggtc actctgttcc caccctcctc tgaggagctt      360

caagccaaca aggccacact ggtgtgtctc gtaagtgact tctacccggg agccgtgaca      420

gtggcctgga aggcagatgg cagccccgtc aaggtgggag tggagaccac caaaccctcc      480

aaacaaagca acaacaagta tgcggccagc agctacctga gcctgacgcc cgagcagtgg      540

aagtcccaca gaagctacag ctgccgggtc acgcatgaag ggagcaccgt ggagaagaca      600

gtggcccctg cagaatgctc t                                                621


<210>  123
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  123
cgtgtgacat tacaacaatc tggggctaca gtgaagcagc ctggggcctc agtgaccgtc       60

tcctgcgaga cttctggata cactttcacc aagtatacca ttcactgggt gcgacaggcc      120

cctggacagg gtcttcagtg ggtgggcaga atacaccccc gaaccggtgc cgtgaagtat      180

gcaccgatat ttcagggtaa agtgtccatg agtcgagact tgtcacgcga cacagcctac      240

ctcggattga ccagactgac gctcgccgac acggctctat ttttctgtgc gaggggggcc      300

tttgaggcag atttaagtgg gccaacttac ccctttcacc actggggcca aggaacccta      360

gtcatcgtct ccgcggcctc caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1365


<210>  124
<211>  621
<212>  DNA
<213>  Homo sapiens

<400>  124
tcctgggccc tgactcaacc cgcctccgtg tctgcgtctc ctgggcagtc ggtcaccatg       60

tcctgcactg gattcggaaa ttataaccct gactcctggt accaacaata cccaggcaaa      120

gcccccaaac tcatcattta tgaggacaat aaaagaccct cgggagtctc taatcgcttc      180

tctgcctcca gacttggcag cacgtcttcc ctgacaatct ctaacgtcca ggccgctgac      240

gacgcccatt atgtctgcgc ctcctttgaa tttttcggcg gagggaccaa gctgatcgtc      300

ctgagtcagc ccaaggctgc cccctcggtc actctgttcc caccctcctc tgaggagctt      360

caagccaaca aggccacact ggtgtgtctc gtaagtgact tctacccggg agccgtgaca      420

gtggcctgga aggcagatgg cagccccgtc aaggtgggag tggagaccac caaaccctcc      480

aaacaaagca acaacaagta tgcggccagc agctacctga gcctgacgcc cgagcagtgg      540

aagtcccaca gaagctacag ctgccgggtc acgcatgaag ggagcaccgt ggagaagaca      600

gtggcccctg cagaatgctc t                                                621


<210>  125
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  125
aacgtgcagt tgatgcagtc tgggactgag gtgaagaagt ctggggcctc ggtgacaatc       60

tcttgtgaga ccgctggatt caacttcatc gactccgtca tacactggct gcgccaggcc      120

cctggaggag gatttcagtg gatggggtgg atcaagcctc ttagaggtgc cgtcaattat      180

ccacagtttt tgcagggcag ggtctccatg acccgggact tgtccaccga cacggtgtac      240

atggtcttga atggactgac acctgacgac acaggccttt attactgcgc gaaaggggcc      300

tttagagggg gttctccctt tggcttctgg ggccagggaa ctctgctcac cgtctcccca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  126
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  126
cagtctgccc tgtctcagcc tgtctccgtg tctgggtctc ctggagagtc gatcaccatt       60

tcctgtactg gagccaccac ctggtatcaa caactcccag gcagaccccc caaactcatc      120

atttatgacg tcactaaccg gccctcaggc atttctagtc gtttctctgg ctccacgtct      180

ggccacacgg cctccctgac aatctccggt ctccaggttg acgacgaggg tctgtatcac      240

tgcgcctcac gtgaattttt cggcggaggg accaagctga ccgtcctgag tcagcccaag      300

gctgccccct cggtcactct gttcccaccc tcctctgagg agcttcaagc caacaaggcc      360

acactggtgt gtctcgtaag tgacttctac ccgggagccg tgacagtggc ctggaaggca      420

gatggcagcc ccgtcaaggt gggagtggag accaccaaac cctccaaaca aagcaacaac      480

aagtatgcgg ccagcagcta cctgagcctg acgcccgagc agtggaagtc ccacagaagc      540

tacagctgcc gggtcacgca tgaagggagc accgtggaga agacagtggc ccctgcagaa      600

tgctct                                                                 606


<210>  127
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  127
caggtgcgac tggtgcagtc tgggcctcag gtgaagaaga ctggggcctc agtgagggtc       60

tcctgcgaaa cctctggata cacgttcacc tcctacttca tccattggtt acgactgggc      120

cccggagagg ggcttcagtg gatggggtgg atcaaccctt tacatggtgc cgtgaattat      180

gaaaacaaat ttaggggcag ggtcacaatc accagggaca cgtccacaga cacagtgtat      240

ttggacatga gcagactgac ccctgacgac acggccgtct atttctgcac aagaggaatc      300

gttgctgatg ggtggcccta tggccactgg ggccagggaa cccaagtcac cgtctccccg      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  128
<211>  609
<212>  DNA
<213>  Homo sapiens

<400>  128
tcctgggccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc ggtcgccatc       60

tcctgcgctg gcggcagcgt ctcctggtac caggtgctcc caggcagagc ccccaaactc      120

atcatttatg agggcgctaa gcgaccctca ggggtttctg ctcgcttctc tggctcccag      180

tctggcaaca cggcttacct gacaatttct gacctccaga ctgaggacga gggcatctac      240

ttctgctctt cacttcaatt cttcggcgga gggaccaaac tgaccgtcct aagtcagccc      300

aaggctgccc cctcggtcac tctgttccca ccctcctctg aggagcttca agccaacaag      360

gccacactgg tgtgtctcgt aagtgacttc tacccgggag ccgtgacagt ggcctggaag      420

gcagatggca gccccgtcaa ggtgggagtg gagaccacca aaccctccaa acaaagcaac      480

aacaagtatg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga      540

agctacagct gccgggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctgca      600

gaatgctct                                                              609


<210>  129
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  129
caggtgcgac ttcagcagtc tggtgtcgtg gtgaggaagc ctggggcctc agtgagaatt       60

tcctgcgaga cttctggatt caccttcatc gaccacattg tccattgggt gcggcgggcc      120

cctggacgag gctttgaatg gatgggttgg atcaagcctc ttaggggtgc cgtagattat      180

gcaccccaac ttcggggcag gatctccctg acgagggaca tttacagtga aaccgtcttt      240

atagacgtga gtcgactgac gtctggcgac acggcgatat acttttgttg taaggccgcc      300

gcccctgaag aagcattccc ccttcaatac tggggccagg ggacccaact tatcgtctcc      360

tcggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  130
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  130
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcctgccttt atgccaatgt agatatctgc tggtatcaac tacacccggg cagagccccc      120

aaacttctaa ttgttgacaa taataagcgg ccctcaggag tctctcctcg cttctctggc      180

tccaagtctg gcaccacggc ctccctgaca atctctggac ttcaggctga cgacgaggct      240

gaatatcact gctcttcaag aacatttttt ggcgggggga ccaagttgac cgtcctgagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  131
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  131
caggtgcgac ttcagcagtc tggtgtcgtg gtgaggaagc ctggggcctc agtgagactt       60

tcctgcgaga cgtctggatt caaattcatc gaccacattg tcaactgggt gcggcgggcc      120

cctggacgag gctttgaatg gatgggttgg atcaagcctc ttgggggtgt cgctgattat      180

gcaccccaac atcggggcag gatctcactg acgagggaca tttacactga aaccgtcttt      240

atagacctga gtcgactgac gtctggcgac acggcgattt atttctgttg taaggccgcc      300

gcccctgatg aagcattccc ccttgaatac tggggccagg ggacccaact tatcgtctcc      360

ccggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  132
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  132
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcctgccttt atgccaatgt agatatctgc tggtatcaaa tacagccggg cagattaccc      120

aaacttctga ttgttgacaa taataggcga ccctcaggag tctctcctcg cttctctggc      180

tccaagtctg gcaccacggc ctccctgaca atctctggac ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacatttttt ggcgggggga ccaagttgac cgtcctcagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  133
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  133
caggtgcgac ttgtgcagtc tggtcccgtg atgagaaagc ctggggcctc agtgagaatt       60

tcttgcgaga catctggatt cgccttcttg gaccacattg tccactgggt gcggcgggcc      120

cctggacgcg gctttgaatg gatgggttgg gttaagacca ttgggggtgt cgttgattat      180

gcaccccacc ttaggggcag gatctccgtg acgagagacg tctttagtga aaccgtcttt      240

ctggacttga gtcgactgac gtctggcgac acggcgatgt atttttgttc taaggccgcc      300

gcccctgacg aagccttccc ccttgaattt tggggccagg ggacccaagt catcgtctcc      360

tcggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  134
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  134
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcttgccttt atgccaatgt ggatatctgc tggtatcaac ttcacccggg cagagccccc      120

aaacttctta ttcttgacaa taataaacgg ccctcaggag tctctagtcg cttctccggt      180

tccaagtctg gcaccacggc ctccctaacc atctctgacc ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacatttttt ggcgggggga ccaggttgac cgtcctgagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  135
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  135
caggtgcgac ttgtgcagtc tggtcccgtg gtgagaaagc ctgggacctc agtgagaatt       60

tcttgcgaga catctggatt cgccttcttg gaccacattg tccactgggt gcggcgggcc      120

cctggacgcg gctttgaatg gatgggttgg gttaagacca ttgggggtgt cgttgattat      180

gcaccccacc ttaggggcag gatctccgtg acgagggacg tatttagtga aatcgtcttt      240

atggagttga gtcgactgac gtctggcgac acggcgatgt atttttgttc taaggccgcc      300

gcccctgacg aagccttccc ccttgaattt tggggccagg ggacccaagt catcgtctcc      360

tcggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  136
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  136
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcctgccttt atgccaatgt ggatatctgc tggtatcaac ttcacccggg cagagccccc      120

aaacttctaa ttgttgacaa taataagcgg ccctcaggag tctctagtcg cttctctggt      180

tccaagtctg gcaccacggc ctccctaaca atctctgatc ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacatttttt ggcgggggga ccaggttgac cgtcctgagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  137
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  137
caagtgcaac tggtgcagtc tggggctggg gtgaagaagc ctggggcctc agtgagggtc       60

tcctgcgaga catccggatt caagttcacc gagtacttta tccacttttt acgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ctcaaccctc tcagaggtgc cgtcaactat      180

ccacggaagt ttcagggcag agtcactttg accagggaca tctacaccac caccgtctac      240

atgcaactta acggtctgac ccctgacgac acggccgtct actactgtgc cagagcggtc      300

tttaatgaag ctttcccctt tgactactgg ggccagggaa gcctggtcac cgtctcctca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  138
<211>  612
<212>  DNA
<213>  Homo sapiens

<400>  138
tcctgggccc agactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcgctg gaatcgtcag tgatgcctgg taccagcaat acccaggcag accccccaga      120

ctcatccttt atgacggcga taagcggccc tcaggggttt ctcctcgttt ttctgcctcc      180

agggccggca agacggcctc cctgacaatt tctgggctgc aggctgacga cgaggcttat      240

tatcactgcg cgtcaaggga attttttgga ggcgtgacca agttgaccgt cctaagtcag      300

cccaaggctg ccccctcggt cactctgttc ccaccctcct ctgaggagct tcaagccaac      360

aaggccacac tggtgtgtct cgtaagtgac ttctacccgg gagccgtgac agtggcctgg      420

aaggcagatg gcagccccgt caaggtggga gtggagacca ccaaaccctc caaacaaagc      480

aacaacaagt atgcggccag cagctacctg agcctgacgc ccgagcagtg gaagtcccac      540

agaagctaca gctgccgggt cacgcatgaa gggagcaccg tggagaagac agtggcccct      600

gcagaatgct ct                                                          612


<210>  139
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  139
caggtgcgac ttcagcagtc tggtgtcgtg gtgaggaagc ctggggcctc agtgagactt       60

tcctgcgaga cgtctggctt caaattcatc gaccacattg tcaactgggt gcggcgggcc      120

cctggacgag gctttgaatg gatgggttgg atcaagcctc ttgggggtgt cgctgattat      180

gcaccccaac atcggggcag gatctcactg acgagggaca tttacactga aaccgtcttt      240

atagacctga gtcgactgac gtctggcgac acggcgattt atttttgttg taaggccgcc      300

gcccctgatg aagcattccc ccttgaatac tggggccagg ggacccaact tatcgtctcc      360

ccggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  140
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  140
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcctgccttt atgccaatgt agatatctgc tggtatcaaa tacagccggg cagattaccc      120

aaacttctga ttgttgacaa tgataggcga ccctcaggag tctctcctcg cttctctggc      180

tccaagtctg gcaccacggc ctccctgaca atctctggac ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacatttttt ggcgggggga ccaagttgac cgtcctcagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  141
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  141
caggtgcgac ttgtgcagtc tggtcccgtg atgagaaagc ctggggcctc agtgagaatt       60

tcttgcgaga catctggatt cgccttcttg gaccacattg tccactgggt gcggcgggcc      120

cctggacgcg gctttgaatg gatgggttgg gttaagacca ttgggggtgt cgttgattat      180

gcaccccacc ttaggggcag gatctccgtg acgagagacg tctttagtga aaccgtcttt      240

ctggacttga gtcgactgac gtctggcgac acggcgatgt atttttgttc taaggccgcc      300

gcccctgacg aagccttccc ccttgaattt tggggccagg ggacccaagt catcgtctcc      360

tcggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  142
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  142
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcttgccttt atgccaatgt ggatatctgc tggtatcaac ttcacccggg cagagccccc      120

aaacttctaa ttcttgacaa taataaacgg ccctcaggag tctctagtcg cttctccggt      180

tccaagtctg gcaccacggc ctccctaacc atctctgacc ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacttttttt ggcgggggga ccaggttgac cgtcctgagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  143
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  143
cacgtgcagt tgaggcagtc tgggactgag gcgaagaagt ctggggcctc ggtgacaatc       60

tcttgtgaga ccgctggatt caacttcatc gactccgtca tacactggct gcgccaggcc      120

cctggtgggg gatttcagtg gatggggtgg atcaagcctc ttagaggtgg cgtcaattat      180

ccacattatt tgcagggcag aatctccatg acccgggact tgtccagtga cacggtttac      240

atggtcttaa atagactgac acctgccgac acaggccttt attactgcgc gaaaggggcc      300

tttgggggga gttctccctt tggcttctgg ggccagggaa ctctgctcac cgtctcccca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  144
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  144
cagtctgccc tgtctcagcc tgtctccgtg tctgggtctc ctggagagtc gatcaccatt       60

tcctgtactg aagccaccac ctggtatcaa caactcccag gcaaaccccc caaactcatc      120

atttatgacg tgaccaaccg gccctcaggc atttcaagtc gtttctctgg ctccatgtct      180

ggtcgcacgg cctccctgac aatctccggt ctccaggttg acgacgaggg tctctatcac      240

tgtgcctcac gtgaattttt cggcgggggg accaagctga ccgtcctgag tcagcccaag      300

gctgccccct cggtcactct gttcccaccc tcctctgagg agcttcaagc caacaaggcc      360

acactggtgt gtctcgtaag tgacttctac ccgggagccg tgacagtggc ctggaaggca      420

gatggcagcc ccgtcaaggt gggagtggag accaccaaac cctccaaaca aagcaacaac      480

aagtatgcgg ccagcagcta cctgagcctg acgcccgagc agtggaagtc ccacagaagc      540

tacagctgcc gggtcacgca tgaagggagc accgtggaga agacagtggc ccctgcagaa      600

tgctct                                                                 606


<210>  145
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  145
cacgtgcaat tgatgcagtc tgggactcag gcgaagaagt ctggggcctc ggtgacaatt       60

tcttgtgaga ccgctggatt caagttcatc gactccgtca tacactggct gcgccaggcc      120

cctggagggg gatttcagtg gatggggtgg atcaagcctc ttggaggtgc cgtcaactat      180

ccaccctatt tgcagggcag gatctccttg acccgtgact tgtccaccga cacaatttac      240

atggtcttga atggactgac acctgccgac acaggctttt attactgcgc caaaggggcc      300

tttggggggg gttctccctt tggcttctgg ggccagggga ctctgctcac cgtctcccca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  146
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  146
cagtctgccc tgtctcagcc tgtctccgtg tctgggtctc ctggagactc gatcaccatt       60

tcttgttttg gagccaccac ctggtatcaa caactcccag gcagaccccc caaactcatc      120

atttatgacg tgactaaccg gccctcaggc atttcaggtc gtttctctgg ctccatgtct      180

ggtcaaaagg cctccctgac aatctccggt ctccaggttg acgacgaggg tctctatcac      240

tgcgcctcac gtgaattttt cggcgggggg accaaactga ccgtcctgag tcagcccaag      300

gctgccccct cggtcactct gttcccaccc tcctctgagg agcttcaagc caacaaggcc      360

acactggtgt gtctcgtaag tgacttctac ccgggagccg tgacagtggc ctggaaggca      420

gatggcagcc ccgtcaaggt gggagtggag accaccaaac cctccaaaca aagcaacaac      480

aagtatgcgg ccagcagcta cctgagcctg acgcccgagc agtggaagtc ccacagaagc      540

tacagctgcc gggtcacgca tgaagggagc accgtggaga agacagtggc ccctgcagaa      600

tgctct                                                                 606


<210>  147
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  147
cacgtgcagt tgaggcagtc tgggactgag gcgaagaagt ctggggcctc ggtgacaatc       60

tcttgtgaga ccgctggatt caacttcatc gactccgtca tacactggct gcgccaggcc      120

cctggtgggg gatttcagtg gatggggtgg atcaagcctc ttagaggtgg cgtcaattat      180

ccacattatt tgcagggcag aatctccatg acccgggact tgtccagtga cacggtttac      240

atggtcttaa atagactgac acctgacgac acaggccttt actactgcgc gaaaggggcc      300

tttgggggga gttctccctt tggcttctgg ggccagggaa ctctgctcac cgtctcccca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  148
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  148
cagtctgccc tgtctcagcc tgtctccgtg tctgggtctc ctggagagtc gatcaccatt       60

tcctgtactg aagccaccac ctggtatcaa caactcccag ggagatcccc caaactcatt      120

atttatgacg tgaccaaccg gccctcaggc atttcaagtc gtttctctgg ctccatgtct      180

ggtcgcacgg cctccctgac aatctccggt ctccaggttg acgacgaggg tctctatcac      240

tgtgcctcac gtgaattttt cggcgggggg accaagctga ccgtcctcag tcagcccaag      300

gctgccccct cggtcactct gttcccaccc tcctctgagg agcttcaagc caacaaggcc      360

acactggtgt gtctcgtaag tgacttctac ccgggagccg tgacagtggc ctggaaggca      420

gatggcagcc ccgtcaaggt gggagtggag accaccaaac cctccaaaca aagcaacaac      480

aagtatgcgg ccagcagcta cctgagcctg acgcccgagc agtggaagtc ccacagaagc      540

tacagctgcc gggtcacgca tgaagggagc accgtggaga agacagtggc ccctgcagaa      600

tgctct                                                                 606


<210>  149
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  149
cgtgttacat tacaacagtc tggggctaca gtgaggcagc ctggggcctc agtcaccgtc       60

tcctgcgaga cttctggatt caccttcatc aaatatacca ttcactgggt gcgacaggcc      120

cctggacagg gtcttcagtg ggtgggaaga atacaccccc gaaccggtgc cgtgaagttt      180

gcaccgatat ttcagggtaa attttccatg agtcgagact tgtcacgcga cacagcctac      240

ctcggattga ccagactgac actcgccgac acggctctat ttttctgtgc gaggggggcc      300

tttgaggcag atttatatgg gccaacttac ccctttcacc actggggcca aggaacccaa      360

gtcaccgtct ccgcggcctc caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1365


<210>  150
<211>  621
<212>  DNA
<213>  Homo sapiens

<400>  150
tcctgggccc tgactcaacc cgcctccgtg tctgcgtctc ctgggcagtc ggtcaccatg       60

tcctgcactg gattcggaag ttataatcct gactcctggt accagcaata cccaggcaaa      120

gcccccaaac tcatcattta tgatgacaat aaaagaccct cgggggtctc tgatcgcttc      180

tctgcctcca gacttggcag cacatcttca ctgacaatct ctaacgtcca ggccgctgac      240

gacgcccatt atgtctgcgc ctcctttgag tttttcggcg gggggaccaa gctgaccgtc      300

ctgagtcagc ccaaggctgc cccctcggtc actctgttcc caccctcctc tgaggagctt      360

caagccaaca aggccacact ggtgtgtctc gtaagtgact tctacccggg agccgtgaca      420

gtggcctgga aggcagatgg cagccccgtc aaggtgggag tggagaccac caaaccctcc      480

aaacaaagca acaacaagta tgcggccagc agctacctga gcctgacgcc cgagcagtgg      540

aagtcccaca gaagctacag ctgccgggtc acgcatgaag ggagcaccgt ggagaagaca      600

gtggcccctg cagaatgctc t                                                621


<210>  151
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  151
cacattcagt tgctacagtc ggggcctcaa gttaagaagt ctggggacac agtgagaatc       60

tcctgtgaga cctctggata taatttcgtc gactccctta tccactgggt ccgacagacc      120

ccggaaaaac gtctcagatg gatgggctgg atcaatcctc tccaaggtgg tgtgaattac      180

gcgccggaat ttcagggcag aatcaggatg accagggaca cgtttataga cacagtttac      240

gtggacttga gcggactgac accggccgac acggcctatt attactgcgc gcgagggatc      300

gatggcaatt cttacccctt tcatttctgg ggccacggaa cccgggtcac cgtcttctcg      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  152
<211>  609
<212>  DNA
<213>  Homo sapiens

<400>  152
cgatttgccc tgactcaacc tgcctccgtg tctgggtctc ctggacagac gatcaccata       60

acctgcgctg gaggcagcgt ctcctggttc catttccctc caggcaaaac ccccagactc      120

attatttatg agtcttctaa gagaccctca ggggtctctc ctcgattctc tgggtcccag      180

tctggcagca cggcctccct aataatttct ggcctccagt ctgatgacga agggacatac      240

ttctgttcta ttcttgaatt tttcggcaga gggactcttc tcaccgtcct gagtcagccc      300

aaggctgccc cctcggtcac tctgttccca ccctcctctg aggagcttca agccaacaag      360

gccacactgg tgtgtctcgt aagtgacttc tacccgggag ccgtgacagt ggcctggaag      420

gcagatggca gccccgtcaa ggtgggagtg gagaccacca aaccctccaa acaaagcaac      480

aacaagtatg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga      540

agctacagct gccgggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctgca      600

gaatgctct                                                              609


<210>  153
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  153

Ala Gly Leu Met Gln Ser Gly Ala Val Met Lys Asn Ser Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Gln Ala Asp Gly Tyr Asp Phe Ile Asp Tyr Val 
            20                  25                  30          


Ile His Trp Phe Arg Gln Arg Arg Gly Glu Gly Leu Glu Trp Leu Gly 
        35                  40                  45              


Trp Met Asn Pro Ser Gly Gly Gly Thr Asn Tyr Pro Arg Pro Phe Gln 
    50                  55                  60                  


Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Glu Thr Ala Tyr Leu 
65                  70                  75                  80  


Asp Val Arg Gly Leu Thr Tyr Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ala Asn Gly Ser Gly Arg Arg Arg Phe Glu Ser Val Asn 
            100                 105                 110         


Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr Gln Ile Thr Val Val Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  154
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  154
gcgggactga tgcagtctgg ggctgtgatg aagaattcgg gggcctcagt gagggtctct       60

tgtcaggctg atggatacga cttcattgac tatgtcattc actggtttcg acaaagacgt      120

ggagaaggtc ttgagtggct gggatggatg aatccctcgg gaggcggcac aaactatccg      180

cgaccatttc agggcaaagt caccatgacc agggacacgt ccaccgagac agcctattta      240

gatgtcagag gacttacata tgacgacacg gccgtctatt attgtgtgag agacagggcc      300

aacggttcgg gaagaagacg ttttgagtcg gtgaattggt tcctggatct gtggggccgc      360

ggcacccaaa taacagtcgt ctcggcctcc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg      960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1080

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1374


<210>  155
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  155

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Thr Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Gly 
65                  70                  75                  80  


His Tyr Phe Cys Trp Ala Phe Glu Asn Ile Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  156
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  156
cagtctgccc taactcagcc tcgctcagtg tccgcatctc ctggtcagtc agtcaccatc       60

tcctgcactg gaacacacaa ttatgtgtcc tggtgtcaac agaaaccggg ccaagccccc      120

aaattattaa tttacgattt caataaacgg ccctcagggg tctctgatcg cttctctggc      180

tccacgtctg gcaacacggc ctccctgacc atctctggac tccaggctga cgatgagggt      240

cattattttt gttgggcgtt tgaaaatatc ggcggaggga ccaagctgac cgtcctgggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  157
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  157

Ala Gly Leu Met Gln Ser Gly Ala Val Met Lys Asn Ser Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Gln Ala Asp Gly Tyr Asp Phe Ile Asp Tyr Val 
            20                  25                  30          


Ile His Trp Phe Arg Gln Arg Arg Gly Glu Gly Leu Glu Trp Leu Gly 
        35                  40                  45              


Trp Met Asn Pro Ser Gly Gly Gly Thr Asn Tyr Pro Arg Pro Phe Gln 
    50                  55                  60                  


Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Glu Thr Ala Tyr Leu 
65                  70                  75                  80  


Asp Val Arg Gly Leu Thr Tyr Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ala Asn Gly Ser Gly Arg Arg Arg Phe Glu Ser Val Asn 
            100                 105                 110         


Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr Gln Ile Thr Val Val Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  158
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  158
gcgggactga tgcagtctgg ggctgtgatg aagaattcgg gggcctcagt gagggtctct       60

tgtcaggctg atggatacga cttcattgac tatgtcattc actggtttcg acaaagacgt      120

ggagaaggtc ttgagtggct gggatggatg aatccctcgg gaggcggcac aaactatccg      180

cgaccatttc agggcaaagt caccatgacc agggacacgt ccaccgagac agcctattta      240

gatgtcagag gacttacata tgacgacacg gccgtctatt attgtgtgag agacagggcc      300

aacggttcgg gaagaagacg ttttgagtcg gtgaattggt tcctggatct gtggggccgc      360

ggcacccaaa taacagtcgt ctcggcctcc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg      960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1080

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1374


<210>  159
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  159

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Thr Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Gly 
65                  70                  75                  80  


His Tyr Phe Cys Trp Ala Phe Glu Asn Ile Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  160
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  160
cagtctgccc taactcagcc tcgctcagtg tccgcatctc ctggtcagtc agtcaccatc       60

tcctgcactg gaacacacaa ttatgtgtcc tggtgtcaac agaaaccggg ccaagccccc      120

aaattattaa tttacgattt caataaacgg ccctcagggg tctctgatcg cttctctggc      180

tccacgtctg gcaacacggc ctccctgacc atctctggac tccaggctga cgatgagggt      240

cattattttt gttgggcgtt tgaaaatatc ggcggaggga ccaagctgac cgtcctgggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  161
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  161

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  162
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  162
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  163
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  163

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  164
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  164
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  165
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  165

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ser 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  166
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  166
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc atcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  167
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  167

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  168
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  168
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  169
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  169

Ala Asp Leu Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser Val 
1               5                   10                  15      


Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile Ile 
            20                  25                  30          


His Trp Ile Arg Arg Ala Val Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  170
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  170
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  171
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  171

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Ala 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  172
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  172
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tgggctcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  173
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  173

Ala Asp Leu Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser Val 
1               5                   10                  15      


Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile Ile 
            20                  25                  30          


His Trp Ile Arg Arg Ala Val Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  174
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  174
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  175
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  175

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Phe 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  176
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  176
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtttcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  177
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  177

Ala Asp Leu Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser Val 
1               5                   10                  15      


Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile Ile 
            20                  25                  30          


His Trp Ile Arg Arg Ala Val Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  178
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  178
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  179
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  179

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Ser 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  180
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  180
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtctcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  181
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  181

Ala Asp Leu Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser Val 
1               5                   10                  15      


Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile Ile 
            20                  25                  30          


His Trp Ile Arg Arg Ala Val Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  182
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  182
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  183
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  183

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Tyr 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  184
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  184
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtatcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  185
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  185

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  186
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  186
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaacgt acggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  187
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  187

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  188
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  188
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  189
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  189

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  190
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  190
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gctgcatgag     1320

gctctgcaca gccactacac gcagaagagc ctctccctgt ccccgggtaa a              1371


<210>  191
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  191

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  192
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  192
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  193
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  193

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  194
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  194
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gctgcatgag     1320

gctctgcaca gccactacac gcagaagagc ctctccctgt ccccgggtaa a              1371


<210>  195
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  195

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  196
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  196
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  197
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  197

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  198
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  198
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctctatatca cccgggagcc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  199
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  199

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  200
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  200
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  201
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  201

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  202
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  202
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  203
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  203

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Thr Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Gly 
65                  70                  75                  80  


His Tyr Phe Cys Trp Ala Phe Glu Asn Ile Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  204
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  204
cagtctgccc taactcagcc tcgctcagtg tccgcatctc ctggtcagtc agtcaccatc       60

tcctgcactg gaacacacaa ttatgtgtcc tggtgtcaac agaaaccggg ccaagccccc      120

aaattattaa tttacgattt caataaacgg ccctcagggg tctctgatcg cttctctggc      180

tccacgtctg gcaacacggc ctccctgacc atctctggac tccaggctga cgatgagggt      240

cattattttt gttgggcgtt tgaaaatatc ggcggaggga ccaagctgac cgtcctgggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  205
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  205

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  206
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  206
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  207
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  207

Gln Cys Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Asn Ala Pro Lys Leu Leu Leu Tyr Asp Phe Asp 
        35                  40                  45              


Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly Ser Arg Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Phe Glu Ala Phe Gly Gly Gly Thr Lys Val 
                85                  90                  95      


Leu Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  208
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  208
cagtgtgtct tgactcagcc tcgctcagtg tccggatctc ctggacaatc agtcaccatc       60

tcctgcactg gaactcacaa ttatgtctcc tggtgtcaac accacccagg caacgccccc      120

aaattattac tttatgattt cgacaagcgg ccctcaggaa tctctgatcg cttctctggc      180

tctaggtctg gcaacacggc ctccctgacc atctctggcc tccagcctga ggatgaggcc      240

gattactttt gttgggcctt tgaagccttt ggcggaggga ccaaggtgct cgtccttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  209
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  209

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ser 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  210
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  210
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc atcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  211
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  211

Ala Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  212
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  212
gcatctgccc tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacgtaca tttgcaatac atatgaattc tttggcggag ggaccagatt gaccgtccta      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  213
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  213

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ser 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  214
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  214
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc atcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  215
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  215

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Tyr Asp Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  216
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  216
cagtctgccc tgactcagcc tcgctcagtg tccgcaactc ctggacagtc agtcaccatc       60

tcctgcactg gaacccacaa ttatgtctct tggtgtcaac aacatccagg cagagccccc      120

aaattactaa tttatgactt caataagagg ccctcagggg tcccggatcg cttctctggc      180

tccggatctg gcggcacggc ctccctaacc atcactggac tccaggatga cgatgaagcg      240

gactattttt gttgggccta tgatgctttt ggcggaggga ccaagttgac cgtcctgcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  217
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  217

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg Ser 
    130                 135                 140                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Val Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Ile Lys Thr Cys Gly Gly Gly Ser Lys Pro Pro Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro 
    290                 295                 300                 


Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Gln Lys Thr Ile Ser Lys Asp 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Glu Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Val Val Glu Trp Glu Ser Ser Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Thr Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Tyr Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  218
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  218
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgtggg      360

actgcggtca caattcaatc agcctcgacc aagggcccat cggtcttccc cctggcgccc      420

tcctccagga gcacctccga gagcacagcg gccctgggct gcctggtcaa ggactacttc      480

cctgaacccg tgaccgtgtc gtggaactca ggctccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc agggctctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacgtctgc aacgtaaacc acaagcccag caacaccaag      660

gtggacaaga gagttgagat aaaaacatgt ggtggtggca gcaaacctcc cacgtgccca      720

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      780

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt agacgtgagc      840

caggaagacc ccgatgtcaa gttcaactgg tacgtaaatg gcgcggaggt gcatcatgcc      900

cagacgaagc cacgggagac gcagtacaac agcacatatc gtgtggtcag cgtcctcacc      960

gtcacgcacc aggactggct gaacggcaag gagtacacgt gcaaggtctc caacaaagcc     1020

ctcccggccc ccatccagaa aaccatctcc aaagacaaag ggcagccccg agagcctcag     1080

gtgtacaccc tgcccccgtc ccgggaggag ctgaccaaga accaggtcag cctgacctgc     1140

ctggtcaaag gcttctaccc cagtgacatc gtcgtggagt gggagagcag cgggcagccg     1200

gagaacacct acaagaccac cccgcccgtg ctggactccg acggctccta cttcctctac     1260

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1320

ctgcatgagg ctctgcacag ccactacacg cagaagagcc tctccctgtc cccgggtaaa     1380


<210>  219
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  219

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Glu Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Ala Val Asn Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Ser Asp 
                165                 170                 175     


Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  220
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  220
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cgagcgagga gcttcaagcc      360

aacaaggcca cactagtgtg tctgatcagt gacttctacc cgggagccgt ggaagtggcc      420

tggaaggcag atggcagcgc tgtcaacgcg ggagtggaga ccaccaaacc ctccaaacag      480

agcaacaaca agtacgcggc cagcagctac ctgagcctga cgtccgacca gtggaagtcc      540

cacaagagct acagctgcca ggtcacgcac gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gttca                                                       615


<210>  221
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  221

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Lys Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Gln Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Arg Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Val His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  222
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  222
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatacaa atttcctgac tacatcattc actggattcg acgcgcccct      120

ggacaaggcc ttgagtggat ggggtggatt aatccaatgg gcggacaagt aaacattcca      180

tggcagtttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccctctatt attgcgtgag agatcgaagt      300

aatggatcgg gaaggcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgcggtca ctgttcattc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  223
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  223

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  224
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  224
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  225
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  225

Ser Ala Glu Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Gln Ala Tyr Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Val Tyr Gly Gln Val Asn Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Asp Ile Tyr Arg Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Val Arg Asp Leu Lys Thr Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Thr Gly Asp Gly Ser Arg Arg His Phe Asp Ser Ile Asn 
            100                 105                 110         


Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr Trp Ile Arg Val Ala Pro 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  226
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  226
tcggcggaat tggtgcaatc tggggctgtg gtgaagaagc ctgggacctc cgtgaaggtc       60

tcttgtcagg cttatggata cacttttacc gactacctta ttcattggct tcgacaggcc      120

cctggacaag gacttgaatg gatgggatgg atgaatcctg tttatggaca agtaaattat      180

gcccaaaact ttcagggcag ggtctccatg accagggaca tttacaggga aacagcattt      240

ctagaggtgc gcgacctgaa gactgacgac acaggcactt attattgtgt gagagacaca      300

ggcgacggtt cgcggagaca ctttgactcc atcaattggt ttctcgatct ttggggccgc      360

gggacatgga taagggtcgc cccagcctcc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg      960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1080

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1374


<210>  227
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  227

Gln Cys Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Asn Ala Pro Lys Leu Leu Leu Tyr Asp Phe Asp 
        35                  40                  45              


Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly Ser Arg Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Phe Glu Ala Phe Gly Gly Gly Thr Lys Val 
                85                  90                  95      


Leu Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  228
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  228
cagtgtgtct tgactcagcc tcgctcagtg tccggatctc ctggacaatc agtcaccatc       60

tcctgcactg gaactcacaa ttatgtctcc tggtgtcaac accacccagg caacgccccc      120

aaattattac tttatgattt cgacaagcgg ccctcaggaa tctctgatcg cttctctggc      180

tctaggtctg gcaacacggc ctccctgacc atctctggcc tccagcctga ggatgaggcc      240

gattactttt gttgggcctt tgaagccttt ggcggaggga ccaaggtgct cgtccttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  229
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  229

Ala Asp Leu Val Gln Ser Gly Ala Val Met Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Arg Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asp Pro Pro Tyr Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Trp Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  230
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  230
gcggacttgg tgcagtctgg ggctgtgatg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc gaggatacac attcactgac tacgtcattc actggattcg acgcgcccct      120

ggacaaggcc ttgaatggat ggggtggatt gatccacctt atggacaagt aaatattcca      180

tggaattttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

aatggatggg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcactc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  231
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  231

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  232
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  232
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagagccccc      120

aagttattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctaacc atcagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac tgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  233
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  233

Ala Asp Leu Val Gln Ser Gly Ala Val Met Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Arg Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asp Pro Pro Tyr Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Trp Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  234
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  234
gcggacttgg tgcagtctgg ggctgtgatg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc gaggatacac attcactgac tacgtcattc actggattcg acgcgcccct      120

ggacaaggcc ttgaatggat ggggtggatt gatccacctt atggacaagt aaatattcca      180

tggaattttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

aatggatggg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcactc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  235
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  235

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  236
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  236
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagagccccc      120

aagttattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctaacc atcagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac tgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  237
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  237

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Pro Gly Tyr Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Trp Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  238
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  238
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc aaggatacac attcactgac tacgtcattc actggattcg acgcgcccct      120

ggacaaggcc ttgaatggat ggggtggatt aatccaggtt atggacaagt aaatattcca      180

tggaactttc agggcagggt ctccatgacc cgagacacgt ccatcgaaac agcatttctg      240

gacttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

aatggatggg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcactc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  239
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  239

Gln Ser Ala Leu Thr Gln Pro Arg Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Ile Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  240
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  240
cagtctgccc tgactcagcc tcgctcaatg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcagtggac tccaggatga cgatgacgcc      240

gaatacattt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  241
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  241

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Asn Ala Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Val Asp Tyr Phe 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met Gly 
        35                  40                  45              


Tyr Met Asp Pro Leu Asn Gly Arg Pro Asn Ile Ala Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Leu Ser Leu Ser Arg Asp Arg Ser Ser Glu Thr Ser Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Asn Gly Ser Gly Arg Arg Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Arg Val Ser Ile Phe Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  242
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  242
gcggacttgg tgcagtctgg ggctgtggtg aaaaatgctg gggcctcagt gagggtctcc       60

tgtgaggctt atggatacac attcgtggac tacttcattc attgggtccg acaggcccct      120

ggacaaggct ttgaatggat gggatacatg gatcccttga acgggcgccc aaacattgcg      180

cgaaaatttc agggcaggct ctccctgagt cgagataggt ccagcgaaac ttcatttctg      240

gacttaagtg gactgaggtc tgacgactcg gccgtctatt attgtgtgag agacaagagt      300

aatggatcgg gcagacggtt tgactcgtct aattggtttc tcgatctgtg gggccgtgga      360

acccgggtca gtattttctc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  243
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  243

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Tyr Asp Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  244
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  244
cagtctgccc tgactcagcc tcgctcagtg tccgcaactc ctggacagtc agtcaccatc       60

tcctgcactg gaacccacaa ttatgtctct tggtgtcaac aacatccagg cagagccccc      120

aaattactaa tttatgactt caataagagg ccctcagggg tcccggatcg cttctctggc      180

tccggatctg gcggcacggc ctccctaacc atcactggac tccaggatga cgatgaagcg      240

gactattttt gttgggccta tgatgctttt ggcggaggga ccaagttgac cgtcctgcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  245
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  245

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Ser Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Arg Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  246
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  246
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagggtctcc       60

tgtgaggctt atggatacac attcagtgac tacatcattc attggattcg acgggcccct      120

ggacgaggcc ttgaatggat gggatggatg aatccgatgg gcggacaagt gaatattccg      180

tggaactttc aggggagagt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactgaggtc tgacgacacg gccgtctatt actgtgtgag agatcgcagc      300

aatggatcgg gcaagcgatt tgagtcctcc aattggttcc tcgatctgtg gggccgcggg      360

accgcggtca ctatttcctc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  247
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  247

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Val Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  248
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  248
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtttct tggtgtcaac atcacccagg cagagccccc      120

aagttattaa tttatgactt caataagaga ccctcaggtg tccctgatcg tttctctggc      180

tccgggtctg gcggcacggc ctccctaacc atcactggac tccaggatga cgatgaggct      240

gaatattttt gttgggcgta tgaagttttt ggcggaggga ccaagttgac cgtgcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  249
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  249

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Thr Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Ile Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Leu Gly 
        35                  40                  45              


Tyr Ile Asp Pro Met Asn Gly Arg Pro Asn Ile Ala Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Ile Glu Thr Ser Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Asn Gly Ser Gly Lys Arg Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Arg Val Ser Ile Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  250
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  250
gcggacttgg tgcagtctgg ggctgtggtg aagacgcctg gggcctcagt gagggtctcc       60

tgtgaggctt atggatacac attcattgac tacatcattc attgggtccg acaggcccct      120

ggacaaggtt ttgaatggct gggatacatt gatcctatga acgggcgccc aaacattgcg      180

cgaaaatttc agggcaggct ctccctgagc cgggatacgt ccatcgaaac atcatttctg      240

gacttaagtg gactgaggtc tgacgactcg gccgtctatt attgtgtgag agacaagagt      300

aatggatcgg gcaaacgatt tgactcctct aattggtttc tcgatctgtg gggccgtgga      360

acgcgggtca gcatttcttc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  251
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  251

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Arg Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Tyr Asp Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  252
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  252
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc agtcaccatc       60

tcctgcactg gaacccacaa ttatgtctct tggtgtcaac aacatccagg cagagccccc      120

aaattactaa tttatgactt caataagagg ccctcagggg tcccggatcg cttctctggc      180

tccggatctg gcggcacggc ctccctaacc atcactagac tccaggatga cgatgacgct      240

gactattttt gttgggcgta tgatgctttt ggcggaggga ccaagttgac cgtcctgggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  253
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  253

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Thr Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Ile Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Leu Gly 
        35                  40                  45              


Tyr Ile Asp Pro Met Asn Gly Arg Pro Asn Ile Ala Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Ile Glu Thr Ser Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Asn Gly Ser Gly Lys Arg Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Arg Val Ser Ile Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  254
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  254
gcggacttgg tgcagtctgg ggctgtggtg aagacgcctg gggcctcagt gagggtctcc       60

tgtgaggctt atggatacac attcattgac tacatcattc attgggtccg acaggcccct      120

ggacaaggtt ttgaatggct gggatacatt gatcctatga acgggcgccc aaacattgcg      180

cgaaaatttc agggcaggct ctccctgagc cgggatacgt ccatcgaaac atcatttctg      240

gacttaagtg gactgaggtc tgacgactcg gccgtctatt attgtgtgag agacaagagt      300

aatggatcgg gcaaacgatt tgactcctct aattggtttc tcgatctgtg gggccgtgga      360

acgcgggtca gcatttcttc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  255
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  255

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Arg Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Tyr Asp Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  256
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  256
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc agtcaccatc       60

tcctgcactg gaacccacaa ttatgtctct tggtgtcaac aacatccagg cagagccccc      120

aaattactaa tttatgactt caataagagg ccctcagggg tcccggatcg cttctctggc      180

tccggatctg gcggcacggc ctccctaacc atcactagac tccaggatga cgatgacgct      240

gactattttt gttgggcgta tgatgctttt ggcggaggga ccaagttgac cgtcctgcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  257
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  257

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Thr Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Arg Thr Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Asn Gly Ser Gly Lys Arg Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Pro Val Thr Ile Ser Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  258
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  258
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggcctcagt gagggtctcc       60

tgtgaggctt atggatacac attcactgac tacatcattc attggattcg acaggcccct      120

ggacaaggcc ttgaatggat gggatggatg aatcctatgg gcgggcgcac aaatattccg      180

tggaaatttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagtg gactaacgtc tgacgacacg gccgtctatt attgcgtgag agacaagagt      300

aatggatcgg gcaaacgatt tgactcctct aattggttcc tcgatctgtg gggccgcgga      360

accccggtca ctatttcctc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  259
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  259

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Ser Ile Thr Gly Leu Gln Asp Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  260
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  260
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac aacacccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctaagt atcactggac tccaggatga cgatgaagct      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgtccttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  261
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  261

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Val Ser Cys Glu Ala Tyr Gly Tyr Thr Phe Val Asp Tyr Leu 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met Gly 
        35                  40                  45              


Tyr Met Asp Pro Met Asn Gly Arg Pro Asn Ile Ala Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Leu Ser Leu Ser Arg Asp Thr Ser Ile Glu Thr Ser Phe Leu 
65                  70                  75                  80  


Asp Leu Ser Gly Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Lys Ser Gly Gly Ser Gly Lys Leu Phe Asp Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Arg Val Ser Ile Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  262
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  262
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggcctcagt gcgggtctcc       60

tgtgaggctt atggatatac attcgttgac tacctcattc attgggtccg acaggccccc      120

ggacaaggtt ttgaatggat gggatacatg gatcctatga acgggcgccc aaatattgcg      180

cgaaaatttc agggcaggct ctccctgagc cgagatacgt ccatcgaaac atcatttctg      240

gacttaagtg gactgaggtc tgacgactcg gccgtctatt attgtgtgag agacaagagt      300

ggtggatcgg gcaaactatt tgactcctct aattggtttc tcgatctgtg gggccgtgga      360

acccgggtca gcatttcttc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  263
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  263

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Tyr Val Ser Trp Cys 
            20                  25                  30          


Gln Gln His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Asp Tyr Phe Cys Trp Ala Tyr Asp Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  264
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  264
cagtctgccc tgactcagcc tcgctcagtg tccgcagctc ctggacagtc agtcaccatc       60

tcctgcaccg gaactcacaa ttatgtctct tggtgtcaac aacatccagg cagagccccc      120

aaattactaa tttatgactt caataagagg ccctcagggg tcccggatcg cttctctggc      180

tccggatctg gcggcacggc ctccctaacc atcactggac tccaggatga cgatgacgct      240

gattattttt gttgggcgta tgatgctttt ggcggaggga ccaagttgac cgtcctgcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  265
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  265

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Asn Pro Gly Tyr Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Glu Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Trp Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Ile Thr Val His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  266
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  266
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc aaggatacac attcactgac tacgtcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggtggatt aatccaggtt atggacaagt aaatattcca      180

tggaactttc agggcagggt ctccatgacc cgagacacgt ccatcgaaac agcttttctg      240

gagttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

aatggatggg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtgatta ctgttcactc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  267
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  267

Gln Ser Ala Leu Thr Gln Pro Arg Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Ile Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Ile Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  268
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  268
cagtctgccc tgactcagcc tcgctcaatg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatacattt gttgggcata tgaagctttc ggcggaggga ccaagttgac catacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  269
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  269

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asp Pro Ser Tyr Gly Gln Val Asn Ile Pro Arg Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Phe Arg Glu Thr Ala Tyr Leu 
65                  70                  75                  80  


Glu Leu Arg Gly Leu Gln Ser Asp Asp Lys Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser His Gly Ser Gly Arg Gln Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Asn Val Gln Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  270
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  270
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc agggatatac attcaccgac tacgtcattc attggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggtggatg gatccaagtt atggacaagt caatattcca      180

cggaactttc agggcagggt ctccatgacc cgggacacgt tcagggaaac agcatatctg      240

gaattaagag gtctacagtc tgacgacaag ggcctctatt attgtgtgag agatcgaagt      300

cacggatcgg gaaggcaatt cgagtcctcc aactggttcc tcgatctgtg gggccgcggc      360

actgtggtca atgttcagtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  271
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  271

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  272
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  272
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacctccc      120

aaattattaa tttatgactt caataagagg gcttcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc attagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  273
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  273

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Leu Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asp Pro Ser Phe Gly Gln Met Asn Ile Pro Arg Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Met Tyr Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser His Gly Ser Gly Arg Leu Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val Gln Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  274
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  274
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcact gagaatctcc       60

tgtgaggctc aaggatacac attcactgac tacgtcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat gggatggatg gatccaagtt ttggacaaat gaacattcca      180

cggaactttc agggcagggt ctccatgacc cgtgacatgt acatcgaaac agcatttctg      240

gacttaagag gtctaaagtc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

catggatcgg gaaggctatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcagtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  275
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  275

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  276
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  276
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacctccc      120

aaattattaa tttatgactt caataagagg gcttcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc attagtggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  277
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  277

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Thr Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Leu Met Asp Pro Ser Phe Gly Arg Met Asn Ile Pro Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Met Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Phe Arg Gly Leu Asn Phe Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser His Gly Ser Gly Arg Leu Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val Gln Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  278
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  278
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatctcc       60

tgtgaggctc aaggatacag attcactgac tacgtcattc attggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggttgatg gatccaagtt ttggacgaat gaatattcca      180

cggaaatttc agggcagggt ctccatgacc cgggacacgt ccatggaaac agcatttctg      240

gacttcagag gtctaaattt tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

catggatcgg gaagactatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggc      360

actgtggtca ctgttcagtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  279
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  279

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  280
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  280
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacctccc      120

aaattattaa tttatgactt caataagagg gcatcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcagtggac tccaagatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  281
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  281

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Thr Phe Ile Asp Tyr Val 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Leu Met Asp Pro Thr Tyr Gly Arg Met Asn Ile Pro Arg Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Gly Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser His Gly Ser Gly Arg Leu Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Val Val Thr Val Gln Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  282
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  282
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gagaatttcc       60

tgtgaggctc aaggatacac attcattgac tacgtcattc actggattcg acgggcccct      120

ggacaaggcc ttgaatggat ggggttgatg gatccaactt atggacgaat gaatattcca      180

cggaagtttc agggcagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gtctaaaatc tgacgacacg ggcctctatt attgcgtgag agatcgaagt      300

catggatcgg gaaggctatt cgagtcctcc aactggttcc tggatctgtg gggccgcggc      360

actgtggtca ctgttcagtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  283
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  283

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Pro Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  284
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  284
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagacctccc      120

aaattattaa tttatgactt caataagagg gcttcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcagtggac tccaagatga cgatgacgcc      240

gaatattttt gttgggcata tgaagctttc ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  285
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  285

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Leu Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile His Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  286
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  286
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatacag atttcttgac tacatcattc actggattcg acgagcccct      120

ggacaaggcc ttgaatggat gggatggatg aatccaatgg gcggacaagt aaacattcca      180

tggaactttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggg      360

actgcggtca ctattcattc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  287
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  287

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  288
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  288
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgtacttcgt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  289
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  289

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Leu Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Asn Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp 
            100                 105                 110         


Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile His Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  290
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  290
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatacag atttcttgac tacatcattc actggattcg acgagcccct      120

ggacaaggcc ttgaatggat gggatggatg aatccaatgg gcggacaagt aaacattcca      180

tggaactttc agggtagggt ctccatgacc cgggacacgt ccatcgaaac agcatttctg      240

gacttaagag gactaaagtc tgacgacacg gccgtctatt attgcgtgag agatcgcagt      300

aatggatcgg gaaagcgatt cgagtcctcc aattggttcc tcgatctgtg gggccgcggg      360

actgcggtca ctattcattc agcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  291
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  291

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His His Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  292
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  292
cagtctgccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcacccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgtacttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  293
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  293

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Thr Gly Tyr Lys Phe Met Asp Gln 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Met Asp Thr Glu Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Gly Glu Asn Tyr Pro Phe His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Arg Val Val Val Ser Ser Pro Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  294
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  294
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgactggata taaattcatg gaccaactca taaactgggt gcggcaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaatccaa catatggaca agtaaattat      180

tcatggagat ttgaaggaag ggtcaccatg accagggaca tggacaccga gacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgc gaggggaccc      300

tctggggaaa attatccttt tcactattgg ggccagggtg tccgagtggt cgtctcgtca      360

ccctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  295
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  295

Ala Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  296
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  296
gcatctgccc tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacgtaca tttgcaatac atatgaattc tttggcggag ggaccagatt gaccgtccta      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  297
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  297

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Thr Gly Tyr Lys Phe Met Asp Gln 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Met Asp Thr Glu Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Gly Glu Asn Tyr Pro Phe His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Arg Val Val Val Ser Ser Pro Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  298
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  298
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgactggata taaattcatg gaccaactca taaactgggt gcggcaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaatccaa catatggaca agtaaattat      180

tcatggagat ttgaaggaag ggtcaccatg accagggaca tggacaccga gacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgc gaggggaccc      300

tctggggaaa attatccttt tcactattgg ggccagggtg tccgagtggt cgtctcgtca      360

ccctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  299
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  299

Ala Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205     


<210>  300
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  300
gcatctgccc tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacgtaca tttgcaatac atatgaattc tttggcggag ggaccagatt gaccgtccta      300

agtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      420

gcttggaaag cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      480

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      540

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctacag aatgttca                                                    618


<210>  301
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  301

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Thr Gly Tyr Lys Phe Met Asp Gln 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Met Asp Thr Glu Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Gly Glu Asn Tyr Pro Phe His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Arg Val Val Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  302
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  302
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgactggata taaattcatg gaccaactca taaactgggt gcggcaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaatccaa catatggaca agtaaattat      180

tcatggagat ttgaaggaag ggtcaccatg accagggaca tggacaccga gacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgc gaggggaccc      300

tctggggaaa attatccttt tcactattgg ggccagggtg tccgagtggt cgtctcgtca      360

tcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  303
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  303

Ala Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  304
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  304
gcatctgccc tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacgtaca tttgcaatac atatgaattc tttggcggag ggaccagatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  305
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  305

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Thr Gly Tyr Lys Phe Met Asp Gln 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Met Asp Thr Glu Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn 
            100                 105                 110         


Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Pro Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  306
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  306
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgactggata taaattcatg gaccaactca taaactgggt gcggcaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaatccaa catatggaca agtaaattat      180

tcatggagat ttgaaggaag ggtcaccatg accagggaca tggacaccga gacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgt gagagatcgc      300

agtaatggat cgggaaagcg attcgagtcc tccaattggg gccagggtgt ccgagtggtc      360

gtctcgtcac cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210>  307
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  307

Ala Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  308
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  308
gcatctgccc tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacgtaca tttgcaatac atatgaattc tttggcggag ggaccagatt gaccgtccta      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  309
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  309

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Thr Gly Tyr Lys Phe Met Asp Gln 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Met Asp Thr Glu Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn 
            100                 105                 110         


Trp Phe Leu Asp Leu Trp Gly Gln Gly Val Arg Val Val Val Ser Ser 
        115                 120                 125             


Pro Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  310
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  310
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgactggata taaattcatg gaccaactca taaactgggt gcggcaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaatccaa catatggaca agtaaattat      180

tcatggagat ttgaaggaag ggtcaccatg accagggaca tggacaccga gacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgt gagagatcgc      300

agtaatggat cgggaaagcg attcgagtcc tccaattggt tcctcgatct gtggggccag      360

ggtgtccgag tggtcgtctc gtcaccctcc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg      960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1080

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1374


<210>  311
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  311

Ala Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  312
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  312
gcatctgccc tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacgtaca tttgcaatac atatgaattc tttggcggag ggaccagatt gaccgtccta      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  313
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  313

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Thr Gly Tyr Lys Phe Met Asp Gln 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Met Asp Thr Glu Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn 
            100                 105                 110         


Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser 
        115                 120                 125             


Ser Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  314
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  314
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgactggata taaattcatg gaccaactca taaactgggt gcggcaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaatccaa catatggaca agtaaattat      180

tcatggagat ttgaaggaag ggtcaccatg accagggaca tggacaccga gacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgt gagagatcgc      300

agtaatggat cgggaaagcg attcgagtcc tccaattggt tcctcgatct gtggggccgt      360

gggactgcgg tcacaattca atcatcctcc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg      960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1080

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1374


<210>  315
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  315

Ala Ser Ala Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  316
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  316
gcatctgccc tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacgtaca tttgcaatac atatgaattc tttggcggag ggaccagatt gaccgtccta      300

cgtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  317
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  317

His Ile Gln Leu Leu Gln Ser Gly Pro Gln Val Lys Lys Ser Gly Asp 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Asn Phe Val Asp Ser 
            20                  25                  30          


Arg Ile His Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu Gln Gly Gly Val Asn Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ile Arg Met Thr Arg Asp Thr Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Val Asp Leu Ser Gly Leu Thr Pro Ala Asp Thr Ala Tyr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Asp Gly Lys Ser Tyr Pro Phe His Phe Trp Gly His 
            100                 105                 110         


Gly Thr Arg Val Thr Val Phe Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  318
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  318
cacattcagt tgctacagtc ggggcctcaa gttaagaagt ctggggacac agtgagaatc       60

tcctgtgaga cctctggata taacttcgtc gactcccgta tccactgggt ccgacagacc      120

ccggaaaaac gtctcagatg gatgggctgg atcaatcctc tccaaggtgg tgtgaattac      180

gcgccggaat ttcagggcag aatcaggatg accagggaca catttataga cacagtttac      240

gtggacctga gcggactgac accggccgac acggcctatt attactgcgc gcgagggatc      300

gatggcaagt cttacccctt tcatttctgg ggccacggaa cccgggtcac cgtcttctcg      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  319
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  319

Arg Phe Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Thr Ile Thr Cys Ala Gly Gly Ser Val Ser Trp Phe His Phe 
            20                  25                  30          


Pro Pro Gly Lys Thr Pro Arg Leu Ile Ile Tyr Glu Ser Ser Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Gln Ser Gly Ser Thr 
    50                  55                  60                  


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ser Asp Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Phe Cys Ser Ile Leu Glu Phe Phe Gly Arg Gly Thr Leu Val Thr Val 
                85                  90                  95      


Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            100                 105                 110         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser 
        115                 120                 125             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
    130                 135                 140                 


Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
145                 150                 155                 160 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                165                 170                 175     


Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr 
            180                 185                 190         


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200             


<210>  320
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  320
cgatttgccc tgactcaacc tgcctccgtg tctgggtctc ctggacagac gatcaccata       60

acctgcgctg gaggcagcgt ctcctggttt catttccctc caggcaaaac ccccagactc      120

attatttatg agtcttctaa gcgaccctct ggggtctctc ctcgattctc tgggtcccag      180

tctggcagca cggcctccct tataatttct ggcctccagt ctgatgacga agggacatac      240

ttctgttcta ttcttgaatt tttcggcaga gggactcttg tcaccgtcct gagtcagccc      300

aaggctgccc cctcggtcac tctgttccca ccctcctctg aggagcttca agccaacaag      360

gccacactgg tgtgtctcgt aagtgacttc tacccgggag ccgtgacagt ggcctggaag      420

gcagatggca gccccgtcaa ggtgggagtg gagaccacca aaccctccaa acaaagcaac      480

aacaagtatg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga      540

agctacagct gccgggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctgca      600

gaatgctct                                                              609


<210>  321
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  321

Gln Val Arg Leu Val Gln Ser Gly Ala Gly Ala Arg Lys Thr Gly Ala 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ser Thr Ser Gly Tyr Thr Phe Thr Thr His 
            20                  25                  30          


His Gly His Phe Ile Asn Trp Val Arg Gln Ala Arg Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Trp Met Asn Pro Met Thr Gly Gln Met Asn Ile Glu 
    50                  55                  60                  


Gly Lys Phe Gln Gly Arg Val Thr Leu Thr Arg Asp Ile Tyr Ser Asp 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Met Thr Arg Leu Thr Thr Gly Asp Thr Gly Thr 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Asp Phe Gly Gln Asn Tyr Pro Phe His Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ser Leu Val Ile Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  322
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  322
caggtgcgct tggtgcagtc tggggctggg gcgaggaaga ctggggcctc aatgaaactt       60

tcctgctcga cctctggata caccttcacc actcatcacg gccacttcat aaattgggtg      120

cgacaggccc gtggacaagg gcttgagtgg atggggtgga tgaatcccat gactgggcag      180

atgaatattg aggggaaatt tcagggcaga gtcaccctca ctcgagacat atacagtgac      240

acggcttaca tggaaatgac cagactgaca actggcgaca cgggcactta ttactgtgcg      300

cgaggcgatt tcggacagaa ttatcccttt cattattggg gccagggaag cctggtcatc      360

gtctcctcgg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210>  323
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  323

Leu Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Asn Arg Tyr Leu Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu Ile Ile Tyr Asp Asp 
        35                  40                  45              


Asn Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Asp Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Thr Gly Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Trp Cys Ala Ser Tyr Glu Arg Phe Gly Gly Gly Thr Arg 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  324
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  324
ctgtctgccc tgactcagcc tgcctccgtg tctgggtctc ctgggcagtc ggtcaccatc       60

tcctgctctg gaacgaaccg ttaccttgtc tcctggtatc aacaacaccc tgacaaagcc      120

cccaaactca tcatttatga cgacaataag cggccctcag gaatttctga tcgcttctca      180

gcctccaggc ctgacgacac ggcctccctg acaatctctg gactccagac tggggacgag      240

gctacttatt ggtgtgcctc atatgaacgt tttggcggcg ggacgaggct gaccgtcctt      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  325
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  325

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Thr Asp Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Gly Glu Asn Tyr Pro Phe His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Arg Val Val Val Ser Ser Pro Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  326
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  326
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accagggaca tgtacaccga cacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgc gaggggaccc      300

tctggggaaa attatccttt tcactattgg ggccagggtg tccgagtggt cgtctcgtca      360

ccctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  327
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  327

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  328
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  328
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

cgtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  329
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  329

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Thr Asp Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Gly Glu Asn Tyr Pro Phe His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Arg Val Val Val Ser Ser Pro Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  330
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  330
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accagggaca tgtacaccga cacggccttc      240

atggagttga gaggactgag agtggacgac acggccgtct attattgcgc gaggggaccc      300

tctggggaaa attatccttt tcactattgg ggccagggtg tccgagtggt cgtctcgtca      360

ccctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  331
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  331

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  332
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  332
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

agtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  333
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  333

His Ile Gln Leu Leu Gln Ser Gly Pro Gln Val Lys Lys Ser Gly Asp 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Asn Phe Val Asp Ser 
            20                  25                  30          


Arg Ile His Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu His Gly Gly Val Asn Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ile Arg Met Thr Arg Asp Thr Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Val Asp Leu Ser Gly Leu Thr Pro Ala Asp Thr Ala Tyr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Asp Gly Lys Ser Tyr Pro Phe His Phe Trp Gly His 
            100                 105                 110         


Gly Thr Arg Val Thr Val Phe Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  334
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  334
cacattcagt tgctacagtc ggggcctcaa gttaagaagt ctggggacac agtgagaatc       60

tcctgtgaga cctctggata taacttcgtc gactcccgta tccactgggt ccgacagacc      120

ccggaaaaac gtctcagatg gatgggctgg atcaatcctc tccacggtgg tgtgaattac      180

gcgccggaat ttcagggcag aatcaggatg accagggaca catttataga cacagtttac      240

gtggacctga gcggactgac accggccgac acggcctatt attactgcgc gcgagggatc      300

gatggcaagt cttacccctt tcatttctgg ggccacggaa cccgggtcac cgtcttctcg      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  335
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  335

Arg Phe Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Thr Ile Thr Cys Ala Gly Gly Ser Val Ser Trp Phe His Phe 
            20                  25                  30          


Pro Pro Gly Lys Thr Pro Arg Leu Ile Ile Tyr Glu Ser Ser Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Gln Ser Gly Ser Thr 
    50                  55                  60                  


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ser Asp Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Phe Cys Ser Ile Leu Glu Phe Phe Gly Arg Gly Thr Leu Val Thr Val 
                85                  90                  95      


Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            100                 105                 110         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser 
        115                 120                 125             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
    130                 135                 140                 


Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
145                 150                 155                 160 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                165                 170                 175     


Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr 
            180                 185                 190         


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200             


<210>  336
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  336
cgatttgccc tgactcaacc tgcctccgtg tctgggtctc ctggacagac gatcaccata       60

acctgcgctg gaggcagcgt ctcctggttt catttccctc caggcaaaac ccccagactc      120

attatttatg agtcttctaa gcgaccctct ggggtctctc ctcgattctc tgggtcccag      180

tctggcagca cggcctccct cataatttct ggcctccagt ctgatgacga agggacatac      240

ttctgttcta ttcttgaatt tttcggcaga gggactcttg tcaccgtcct gagtcagccc      300

aaggctgccc cctcggtcac tctgttccca ccctcctctg aggagcttca agccaacaag      360

gccacactgg tgtgtctcgt aagtgacttc tacccgggag ccgtgacagt ggcctggaag      420

gcagatggca gccccgtcaa ggtgggagtg gagaccacca aaccctccaa acaaagcaac      480

aacaagtatg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga      540

agctacagct gccgggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctgca      600

gaatgctct                                                              609


<210>  337
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  337

Arg Val Thr Leu Gln Gln Ser Gly Ala Ile Val Arg Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Phe Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile His Pro Arg Thr Gly Ala Val Lys Tyr Ala Pro Arg Phe 
    50                  55                  60                  


Gln Gly Arg Leu Ser Met Thr Arg Asp Trp Ser Leu Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Thr Gly Leu Thr Leu Gly Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Phe Glu Ala Asp Ser Tyr Gly Ser Ser Tyr Pro Phe 
            100                 105                 110         


His His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  338
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  338
cgtgttacat tacaacaatc tggggctata gtgaggcagc ctggggcctc agtgaccgtc       60

tcctgcgaga cttctggata tactttcacc aagtatttca tctactgggt gcgacaggcc      120

cctggacagg gtcttgagtg gctgggcaga atacaccccc gaaccggtgc cgtgaagtat      180

gcaccgagat ttcagggtag actgtccatg accagagact ggtcactcga cacagcctac      240

ctcggattga ccggactgac actcggcgac acggctctat atttctgtgc gaggggggcc      300

tttgaggcag attcatatgg gtcaagttat ccctttcacc actggggcca gggaacccta      360

gtcaccgtct ccgcggcctc caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1365


<210>  339
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  339

Ser Trp Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Met Ser Cys Thr Gly Phe Gly Asn Tyr Asn Pro Asp Ser 
            20                  25                  30          


Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Glu 
        35                  40                  45              


Asp Asn Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Ala Ser Arg 
    50                  55                  60                  


Leu Gly Ser Thr Ser Ser Leu Thr Ile Ser Asn Val Gln Ala Ala Asp 
65                  70                  75                  80  


Asp Ala His Tyr Val Cys Ala Ser Phe Glu Phe Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
            100                 105                 110         


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
        115                 120                 125             


Cys Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
    130                 135                 140                 


Ala Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser 
145                 150                 155                 160 


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
                165                 170                 175     


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His 
            180                 185                 190         


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205         


<210>  340
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  340
tcctgggccc tgactcaacc cgcctccgtg tctgcgtctc ctgggcagtc ggtcaccatg       60

tcctgcactg gattcggaaa ttataaccct gactcctggt accaacaata cccaggcaaa      120

gcccccaaac tcatcattta tgaagacaat aaaagaccct cgggggtctc tgatcgcttc      180

tctgcctcca gacttggcag cacgtcttcc ctgacaatct ctaacgtcca ggctgcggac      240

gacgcccatt atgtctgcgc ctcctttgaa tttttcggcg gagggaccaa gctgaccgtc      300

ctgagtcagc ccaaggctgc cccctcggtc actctgttcc caccctcctc tgaggagctt      360

caagccaaca aggccacact ggtgtgtctc gtaagtgact tctacccggg agccgtgaca      420

gtggcctgga aggcagatgg cagccccgtc aaggtgggag tggagaccac caaaccctcc      480

aaacaaagca acaacaagta tgcggccagc agctacctga gcctgacgcc cgagcagtgg      540

aagtcccaca gaagctacag ctgccgggtc acgcatgaag ggagcaccgt ggagaagaca      600

gtggcccctg cagaatgctc t                                                621


<210>  341
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  341

Arg Val Thr Leu Gln Gln Ser Gly Ala Thr Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Arg Ile His Pro Arg Thr Gly Ala Val Lys Tyr Ala Pro Ile Phe 
    50                  55                  60                  


Gln Gly Lys Val Ser Met Ser Arg Asp Leu Ser Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Thr Arg Leu Thr Leu Ala Asp Thr Ala Leu Phe Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Phe Glu Ala Asp Leu Ser Gly Pro Thr Tyr Pro Phe 
            100                 105                 110         


His His Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ala Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  342
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  342
cgtgtgacat tacaacaatc tggggctaca gtgaagcagc ctggggcctc agtgaccgtc       60

tcctgcgaga cttctggata cactttcacc aagtatacca ttcactgggt gcgacaggcc      120

cctggacagg gtcttcagtg ggtgggcaga atacaccccc gaaccggtgc cgtgaagtat      180

gcaccgatat ttcagggtaa agtgtccatg agtcgagact tgtcacgcga cacagcctac      240

ctcggattga ccagactgac gctcgccgac acggctctat ttttctgtgc gaggggggcc      300

tttgaggcag atttaagtgg gccaacttac ccctttcacc actggggcca aggaacccta      360

gtcatcgtct ccgcggcctc caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1365


<210>  343
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  343

Ser Trp Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Met Ser Cys Thr Gly Phe Gly Asn Tyr Asn Pro Asp Ser 
            20                  25                  30          


Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Glu 
        35                  40                  45              


Asp Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Ala Ser Arg 
    50                  55                  60                  


Leu Gly Ser Thr Ser Ser Leu Thr Ile Ser Asn Val Gln Ala Ala Asp 
65                  70                  75                  80  


Asp Ala His Tyr Val Cys Ala Ser Phe Glu Phe Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Ile Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
            100                 105                 110         


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
        115                 120                 125             


Cys Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
    130                 135                 140                 


Ala Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser 
145                 150                 155                 160 


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
                165                 170                 175     


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His 
            180                 185                 190         


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205         


<210>  344
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  344
tcctgggccc tgactcaacc cgcctccgtg tctgcgtctc ctgggcagtc ggtcaccatg       60

tcctgcactg gattcggaaa ttataaccct gactcctggt accaacaata cccaggcaaa      120

gcccccaaac tcatcattta tgaggacaat aaaagaccct cgggagtctc taatcgcttc      180

tctgcctcca gacttggcag cacgtcttcc ctgacaatct ctaacgtcca ggccgctgac      240

gacgcccatt atgtctgcgc ctcctttgaa tttttcggcg gagggaccaa gctgatcgtc      300

ctgagtcagc ccaaggctgc cccctcggtc actctgttcc caccctcctc tgaggagctt      360

caagccaaca aggccacact ggtgtgtctc gtaagtgact tctacccggg agccgtgaca      420

gtggcctgga aggcagatgg cagccccgtc aaggtgggag tggagaccac caaaccctcc      480

aaacaaagca acaacaagta tgcggccagc agctacctga gcctgacgcc cgagcagtgg      540

aagtcccaca gaagctacag ctgccgggtc acgcatgaag ggagcaccgt ggagaagaca      600

gtggcccctg cagaatgctc t                                                621


<210>  345
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  345

Asn Val Gln Leu Met Gln Ser Gly Thr Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Glu Thr Ala Gly Phe Asn Phe Ile Asp Ser 
            20                  25                  30          


Val Ile His Trp Leu Arg Gln Ala Pro Gly Gly Gly Phe Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Arg Gly Ala Val Asn Tyr Pro Gln Phe Leu 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Asp Leu Ser Thr Asp Thr Val Tyr 
65                  70                  75                  80  


Met Val Leu Asn Gly Leu Thr Pro Asp Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Phe Arg Gly Gly Ser Pro Phe Gly Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  346
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  346
aacgtgcagt tgatgcagtc tgggactgag gtgaagaagt ctggggcctc ggtgacaatc       60

tcttgtgaga ccgctggatt caacttcatc gactccgtca tacactggct gcgccaggcc      120

cctggaggag gatttcagtg gatggggtgg atcaagcctc ttagaggtgc cgtcaattat      180

ccacagtttt tgcagggcag ggtctccatg acccgggact tgtccaccga cacggtgtac      240

atggtcttga atggactgac acctgacgac acaggccttt attactgcgc gaaaggggcc      300

tttagagggg gttctccctt tggcttctgg ggccagggaa ctctgctcac cgtctcccca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  347
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  347

Gln Ser Ala Leu Ser Gln Pro Val Ser Val Ser Gly Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Ala Thr Thr Trp Tyr Gln Gln Leu 
            20                  25                  30          


Pro Gly Arg Pro Pro Lys Leu Ile Ile Tyr Asp Val Thr Asn Arg Pro 
        35                  40                  45              


Ser Gly Ile Ser Ser Arg Phe Ser Gly Ser Thr Ser Gly His Thr Ala 
    50                  55                  60                  


Ser Leu Thr Ile Ser Gly Leu Gln Val Asp Asp Glu Gly Leu Tyr His 
65                  70                  75                  80  


Cys Ala Ser Arg Glu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            100                 105                 110         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
        115                 120                 125             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
    130                 135                 140                 


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
145                 150                 155                 160 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                165                 170                 175     


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
            180                 185                 190         


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200         


<210>  348
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  348
cagtctgccc tgtctcagcc tgtctccgtg tctgggtctc ctggagagtc gatcaccatt       60

tcctgtactg gagccaccac ctggtatcaa caactcccag gcagaccccc caaactcatc      120

atttatgacg tcactaaccg gccctcaggc atttctagtc gtttctctgg ctccacgtct      180

ggccacacgg cctccctgac aatctccggt ctccaggttg acgacgaggg tctgtatcac      240

tgcgcctcac gtgaattttt cggcggaggg accaagctga ccgtcctgag tcagcccaag      300

gctgccccct cggtcactct gttcccaccc tcctctgagg agcttcaagc caacaaggcc      360

acactggtgt gtctcgtaag tgacttctac ccgggagccg tgacagtggc ctggaaggca      420

gatggcagcc ccgtcaaggt gggagtggag accaccaaac cctccaaaca aagcaacaac      480

aagtatgcgg ccagcagcta cctgagcctg acgcccgagc agtggaagtc ccacagaagc      540

tacagctgcc gggtcacgca tgaagggagc accgtggaga agacagtggc ccctgcagaa      600

tgctct                                                                 606


<210>  349
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  349

Gln Val Arg Leu Val Gln Ser Gly Pro Gln Val Lys Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Leu Arg Leu Gly Pro Gly Glu Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu His Gly Ala Val Asn Tyr Glu Asn Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Asp Met Ser Arg Leu Thr Pro Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Ile Val Ala Asp Gly Trp Pro Tyr Gly His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  350
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  350
caggtgcgac tggtgcagtc tgggcctcag gtgaagaaga ctggggcctc agtgagggtc       60

tcctgcgaaa cctctggata cacgttcacc tcctacttca tccattggtt acgactgggc      120

cccggagagg ggcttcagtg gatggggtgg atcaaccctt tacatggtgc cgtgaattat      180

gaaaacaaat ttaggggcag ggtcacaatc accagggaca cgtccacaga cacagtgtat      240

ttggacatga gcagactgac ccctgacgac acggccgtct atttctgcac aagaggaatc      300

gttgctgatg ggtggcccta tggccactgg ggccagggaa cccaagtcac cgtctccccg      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  351
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  351

Ser Trp Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Ala Ile Ser Cys Ala Gly Gly Ser Val Ser Trp Tyr Gln Val 
            20                  25                  30          


Leu Pro Gly Arg Ala Pro Lys Leu Ile Ile Tyr Glu Gly Ala Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Ser Ala Arg Phe Ser Gly Ser Gln Ser Gly Asn Thr 
    50                  55                  60                  


Ala Tyr Leu Thr Ile Ser Asp Leu Gln Thr Glu Asp Glu Gly Ile Tyr 
65                  70                  75                  80  


Phe Cys Ser Ser Leu Gln Phe Phe Gly Gly Gly Thr Lys Leu Thr Val 
                85                  90                  95      


Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            100                 105                 110         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser 
        115                 120                 125             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
    130                 135                 140                 


Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
145                 150                 155                 160 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                165                 170                 175     


Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr 
            180                 185                 190         


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200             


<210>  352
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  352
tcctgggccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc ggtcgccatc       60

tcctgcgctg gcggcagcgt ctcctggtac caggtgctcc caggcagagc ccccaaactc      120

atcatttatg agggcgctaa gcgaccctca ggggtttctg ctcgcttctc tggctcccag      180

tctggcaaca cggcttacct gacaatttct gacctccaga ctgaggacga gggcatctac      240

ttctgctctt cacttcaatt cttcggcgga gggaccaaac tgaccgtcct aagtcagccc      300

aaggctgccc cctcggtcac tctgttccca ccctcctctg aggagcttca agccaacaag      360

gccacactgg tgtgtctcgt aagtgacttc tacccgggag ccgtgacagt ggcctggaag      420

gcagatggca gccccgtcaa ggtgggagtg gagaccacca aaccctccaa acaaagcaac      480

aacaagtatg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga      540

agctacagct gccgggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctgca      600

gaatgctct                                                              609


<210>  353
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  353

Gln Val Arg Leu Gln Gln Ser Gly Val Val Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Phe Thr Phe Ile Asp His 
            20                  25                  30          


Ile Val His Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Arg Gly Ala Val Asp Tyr Ala Pro Gln Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Leu Thr Arg Asp Ile Tyr Ser Glu Thr Val Phe 
65                  70                  75                  80  


Ile Asp Val Ser Arg Leu Thr Ser Gly Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Cys Lys Ala Ala Ala Pro Glu Glu Ala Phe Pro Leu Gln Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Leu Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  354
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  354
caggtgcgac ttcagcagtc tggtgtcgtg gtgaggaagc ctggggcctc agtgagaatt       60

tcctgcgaga cttctggatt caccttcatc gaccacattg tccattgggt gcggcgggcc      120

cctggacgag gctttgaatg gatgggttgg atcaagcctc ttaggggtgc cgtagattat      180

gcaccccaac ttcggggcag gatctccctg acgagggaca tttacagtga aaccgtcttt      240

atagacgtga gccgactgac gtctggcgac acggcgatat acttttgttg taaggccgcc      300

gcccctgaag aagcattccc ccttcaatac tggggccagg ggacccaact tatcgtctcc      360

tcggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  355
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  355

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Leu His Pro Gly Arg Ala Pro Lys Leu Leu Ile Val Asp Asn Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Arg Thr Phe Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  356
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  356
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcctgccttt atgccaatgt agatatctgc tggtatcaac tacacccggg cagagccccc      120

aaacttctaa ttgttgacaa taataagcgg ccctcaggag tctctcctcg cttctctggc      180

tccaagtctg gcaccacggc ctccctgaca atctctggac ttcaggctga cgacgaggct      240

gaatatcact gctcttcaag aacatttttt ggcgggggga ccaagttgac cgtcctgagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  357
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  357

Gln Val Arg Leu Gln Gln Ser Gly Val Val Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Glu Thr Ser Gly Phe Lys Phe Ile Asp His 
            20                  25                  30          


Ile Val Asn Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Gly Gly Val Ala Asp Tyr Ala Pro Gln His 
    50                  55                  60                  


Arg Gly Arg Ile Ser Leu Thr Arg Asp Ile Tyr Thr Glu Thr Val Phe 
65                  70                  75                  80  


Ile Asp Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Cys Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Leu Ile Val Ser Pro Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  358
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  358
caggtgcgac ttcagcagtc tggtgtcgtg gtgaggaagc ctggggcctc agtgagactt       60

tcctgcgaga cgtctggatt caaattcatc gaccacattg tcaactgggt gcggcgggcc      120

cctggacgag gctttgaatg gatgggttgg atcaagcctc ttgggggtgt cgctgattat      180

gcaccccaac atcggggcag gatctcactg acgagggaca tttacactga aaccgtcttt      240

atagacctga gtcgactgac gtctggcgac acggcgattt atttctgttg taaggccgcc      300

gcccctgatg aagcattccc ccttgaatac tggggccagg ggacccaact tatcgtctcc      360

ccggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  359
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  359

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Ile Gln Pro Gly Arg Leu Pro Lys Leu Leu Ile Val Asp Asn Asn 
        35                  40                  45              


Arg Arg Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  360
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  360
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcctgccttt atgccaatgt agatatctgc tggtatcaaa tacagccggg cagattaccc      120

aaacttctga ttgttgacaa taataggcga ccctcaggag tctctcctcg cttctctggc      180

tccaagtctg gcaccacggc ctccctgaca atctctggac ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacatttttt ggcgggggga ccaagttgac cgtcctcagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  361
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  361

Gln Val Arg Leu Val Gln Ser Gly Pro Val Met Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Phe Ala Phe Leu Asp His 
            20                  25                  30          


Ile Val His Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Val Lys Thr Ile Gly Gly Val Val Asp Tyr Ala Pro His Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Val Thr Arg Asp Val Phe Ser Glu Thr Val Phe 
65                  70                  75                  80  


Leu Asp Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ser Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  362
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  362
caggtgcgac ttgtgcagtc tggtcccgtg atgagaaagc ctggggcctc agtgagaatt       60

tcttgcgaga catctggatt cgccttcttg gaccacattg tccactgggt gcggcgggcc      120

cctggacgcg gctttgaatg gatgggttgg gttaagacca ttgggggtgt cgttgattat      180

gcaccccacc ttaggggcag gatctccgtg acgagagacg tctttagtga aaccgtcttt      240

ctggacttga gccgactgac gtctggcgac acggcgatgt atttttgttc taaggccgcc      300

gcccctgacg aagccttccc ccttgaattt tggggccagg ggacccaagt catcgtctcc      360

tcggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  363
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  363

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Leu His Pro Gly Arg Ala Pro Lys Leu Leu Ile Leu Asp Asn Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Asp Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Arg Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  364
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  364
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcttgccttt atgccaatgt ggatatctgc tggtatcaac ttcacccggg cagagccccc      120

aaacttctta ttcttgacaa taataaacgg ccctcaggag tctctagtcg cttctccggt      180

tccaagtctg gcaccacggc ctccctaacc atctctgacc ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacatttttt ggcgggggga ccaggttgac cgtcctgagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  365
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  365

Gln Val Arg Leu Val Gln Ser Gly Pro Val Val Arg Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Phe Ala Phe Leu Asp His 
            20                  25                  30          


Ile Val His Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Val Lys Thr Ile Gly Gly Val Val Asp Tyr Ala Pro His Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Val Thr Arg Asp Val Phe Ser Glu Ile Val Phe 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ser Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  366
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  366
caggtgcgac ttgtgcagtc tggtcccgtg gtgagaaagc ctgggacctc agtgagaatt       60

tcttgcgaga catctggatt cgccttcttg gaccacattg tccactgggt gcggcgggcc      120

cctggacgcg gctttgaatg gatgggttgg gttaagacca ttgggggtgt cgttgattat      180

gcaccccacc ttaggggcag gatctccgtg acgagggacg tatttagtga aatcgtcttt      240

atggagttga gtcgactgac gtctggcgac acggcgatgt atttttgttc taaggccgcc      300

gcccctgacg aagccttccc ccttgaattt tggggccagg ggacccaagt catcgtctcc      360

tcggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  367
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  367

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Leu His Pro Gly Arg Ala Pro Lys Leu Leu Ile Val Asp Asn Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Asp Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Arg Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  368
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  368
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcctgccttt atgccaatgt ggatatctgc tggtatcaac ttcacccggg cagagccccc      120

aaacttctaa ttgttgacaa taataagcgg ccctcaggag tctctagtcg cttctctggt      180

tccaagtctg gcaccacggc ctccctaaca atctctgatc ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacatttttt ggcgggggga ccaggttgac cgtcctgagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  369
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  369

Gln Val Gln Leu Val Gln Ser Gly Ala Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Thr Ser Gly Phe Lys Phe Thr Glu Tyr 
            20                  25                  30          


Phe Ile His Phe Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Pro Leu Arg Gly Ala Val Asn Tyr Pro Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Ile Tyr Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Gly Leu Thr Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Asn Glu Ala Phe Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  370
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  370
caagtgcaac tggtgcagtc tggggctggg gtgaagaagc ctggggcctc agtgagggtc       60

tcctgcgaga catccggatt caagttcacc gagtacttta tccacttttt acgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ctcaaccctc tcagaggtgc cgtcaactat      180

ccacggaagt ttcagggcag agtcactttg accagggaca tctacaccac caccgtctac      240

atgcaactta acggtctgac ccctgacgac acggccgtct actactgtgc cagagcggtc      300

tttaatgaag ctttcccctt tgactactgg ggccagggaa gcctggtcac cgtctcctca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  371
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  371

Ser Trp Ala Gln Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Ile Val Ser Asp Ala Trp Tyr Gln 
            20                  25                  30          


Gln Tyr Pro Gly Arg Pro Pro Arg Leu Ile Leu Tyr Asp Gly Asp Lys 
        35                  40                  45              


Arg Pro Ser Gly Val Ser Pro Arg Phe Ser Ala Ser Arg Ala Gly Lys 
    50                  55                  60                  


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Tyr 
65                  70                  75                  80  


Tyr His Cys Ala Ser Arg Glu Phe Phe Gly Gly Val Thr Lys Leu Thr 
                85                  90                  95      


Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
            100                 105                 110         


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val 
        115                 120                 125             


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly 
    130                 135                 140                 


Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser 
145                 150                 155                 160 


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
                165                 170                 175     


Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser 
            180                 185                 190         


Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 


<210>  372
<211>  612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  372
tcctgggccc agactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcgctg gaatcgtcag tgatgcctgg taccagcaat acccaggcag accccccaga      120

ctcatccttt atgacggcga taagcggccc tcaggggttt ctcctcgttt ttctgcctcc      180

agggccggca agacggcctc cctgacaatt tctgggctgc aggctgacga cgaggcttat      240

tatcactgcg cgtcaaggga attttttgga ggcgtgacca agttgaccgt cctaagtcag      300

cccaaggctg ccccctcggt cactctgttc ccaccctcct ctgaggagct tcaagccaac      360

aaggccacac tggtgtgtct cgtaagtgac ttctacccgg gagccgtgac agtggcctgg      420

aaggcagatg gcagccccgt caaggtggga gtggagacca ccaaaccctc caaacaaagc      480

aacaacaagt atgcggccag cagctacctg agcctgacgc ccgagcagtg gaagtcccac      540

agaagctaca gctgccgggt cacgcatgaa gggagcaccg tggagaagac agtggcccct      600

gcagaatgct ct                                                          612


<210>  373
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  373

Gln Val Arg Leu Gln Gln Ser Gly Val Val Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Glu Thr Ser Gly Phe Lys Phe Ile Asp His 
            20                  25                  30          


Ile Val Asn Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Gly Gly Val Ala Asp Tyr Ala Pro Gln His 
    50                  55                  60                  


Arg Gly Arg Ile Ser Leu Thr Arg Asp Ile Tyr Thr Glu Thr Val Phe 
65                  70                  75                  80  


Ile Asp Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Cys Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Leu Ile Val Ser Pro Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  374
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  374
caggtgcgac ttcagcagtc tggtgtcgtg gtgaggaagc ctggggcctc agtgagactt       60

tcctgcgaga cgtctggctt caaattcatc gaccacattg tcaactgggt gcggcgggcc      120

cctggacgag gctttgaatg gatgggttgg atcaagcctc ttgggggtgt cgctgattat      180

gcaccccaac atcggggcag gatctcactg acgagggaca tttacactga aaccgtcttt      240

atagacctga gtcgactgac gtctggcgac acggcgattt atttttgttg taaggccgcc      300

gcccctgatg aagcattccc ccttgaatac tggggccagg ggacccaact tatcgtctcc      360

ccggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  375
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  375

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Ile Gln Pro Gly Arg Leu Pro Lys Leu Leu Ile Val Asp Asn Asp 
        35                  40                  45              


Arg Arg Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  376
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  376
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcctgccttt atgccaatgt agatatctgc tggtatcaaa tacagccggg cagattaccc      120

aaacttctga ttgttgacaa tgataggcga ccctcaggag tctctcctcg cttctctggc      180

tccaagtctg gcaccacggc ctccctgaca atctctggac ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacatttttt ggcgggggga ccaagttgac cgtcctcagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  377
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  377

Gln Val Arg Leu Val Gln Ser Gly Pro Val Met Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Phe Ala Phe Leu Asp His 
            20                  25                  30          


Ile Val His Trp Val Arg Arg Ala Pro Gly Arg Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Val Lys Thr Ile Gly Gly Val Val Asp Tyr Ala Pro His Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Val Thr Arg Asp Val Phe Ser Glu Thr Val Phe 
65                  70                  75                  80  


Leu Asp Leu Ser Arg Leu Thr Ser Gly Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ser Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Ile Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  378
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  378
caggtgcgac ttgtgcagtc tggtcccgtg atgagaaagc ctggggcctc agtgagaatt       60

tcttgcgaga catctggatt cgccttcttg gaccacattg tccactgggt gcggcgggcc      120

cctggacgcg gctttgaatg gatgggttgg gttaagacca ttgggggtgt cgttgattat      180

gcaccccacc ttaggggcag gatctccgtg acgagagacg tctttagtga aaccgtcttt      240

ctggacttga gtcgactgac gtctggcgac acggcgatgt atttttgttc taaggccgcc      300

gcccctgacg aagccttccc ccttgaattt tggggccagg ggacccaagt catcgtctcc      360

tcggcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  379
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  379

Gln Ala Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Leu Tyr Ala Asn Val Asp Ile Cys Trp Tyr 
            20                  25                  30          


Gln Leu His Pro Gly Arg Ala Pro Lys Leu Leu Ile Leu Asp Asn Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Thr Thr Ala Ser Leu Thr Ile Ser Asp Leu Gln Ala Asp Asp Glu Ala 
65                  70                  75                  80  


Glu Tyr His Cys Ser Ser Thr Thr Phe Phe Gly Gly Gly Thr Arg Leu 
                85                  90                  95      


Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205 


<210>  380
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  380
caggctgccc tgactcagcc cgcctccgtg tccggctctc ctggacagtc ggtcaccatt       60

tcttgccttt atgccaatgt ggatatctgc tggtatcaac ttcacccggg cagagccccc      120

aaacttctaa ttcttgacaa taataaacgg ccctcaggag tctctagtcg cttctccggt      180

tccaagtctg gcaccacggc ctccctaacc atctctgacc ttcaggctga cgacgaggct      240

gaatatcact gctcttcaac aacttttttt ggcgggggga ccaggttgac cgtcctgagt      300

cagcccaagg ctgccccctc ggtcactctg ttcccaccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcgtaagt gacttctacc cgggagccgt gacagtggcc      420

tggaaggcag atggcagccc cgtcaaggtg ggagtggaga ccaccaaacc ctccaaacaa      480

agcaacaaca agtatgcggc cagcagctac ctgagcctga cgcccgagca gtggaagtcc      540

cacagaagct acagctgccg ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctgcagaat gctct                                                       615


<210>  381
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  381

His Val Gln Leu Arg Gln Ser Gly Thr Glu Ala Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Glu Thr Ala Gly Phe Asn Phe Ile Asp Ser 
            20                  25                  30          


Val Ile His Trp Leu Arg Gln Ala Pro Gly Gly Gly Phe Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Arg Gly Gly Val Asn Tyr Pro His Tyr Leu 
    50                  55                  60                  


Gln Gly Arg Ile Ser Met Thr Arg Asp Leu Ser Ser Asp Thr Val Tyr 
65                  70                  75                  80  


Met Val Leu Asn Arg Leu Thr Pro Ala Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Phe Gly Gly Ser Ser Pro Phe Gly Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  382
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  382
cacgtgcagt tgaggcagtc tgggactgag gcgaagaagt ctggggcctc ggtgacaatc       60

tcttgtgaga ccgctggatt caacttcatc gactccgtca tacactggct gcgccaggcc      120

cctggtgggg gatttcagtg gatggggtgg atcaagcctc ttagaggtgg cgtcaattat      180

ccacattatt tgcagggcag aatctccatg acccgggact tgtccagtga cacggtttac      240

atggtcttaa atagactgac acctgccgac acaggccttt attactgcgc gaaaggggcc      300

tttgggggga gttctccctt tggcttctgg ggccagggaa ctctgctcac cgtctcccca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  383
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  383

Gln Ser Ala Leu Ser Gln Pro Val Ser Val Ser Gly Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Glu Ala Thr Thr Trp Tyr Gln Gln Leu 
            20                  25                  30          


Pro Gly Lys Pro Pro Lys Leu Ile Ile Tyr Asp Val Thr Asn Arg Pro 
        35                  40                  45              


Ser Gly Ile Ser Ser Arg Phe Ser Gly Ser Met Ser Gly Arg Thr Ala 
    50                  55                  60                  


Ser Leu Thr Ile Ser Gly Leu Gln Val Asp Asp Glu Gly Leu Tyr His 
65                  70                  75                  80  


Cys Ala Ser Arg Glu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            100                 105                 110         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
        115                 120                 125             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
    130                 135                 140                 


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
145                 150                 155                 160 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                165                 170                 175     


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
            180                 185                 190         


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200         


<210>  384
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  384
cagtctgccc tgtctcagcc tgtctccgtg tctgggtctc ctggagagtc gatcaccatt       60

tcctgtactg aagccaccac ctggtatcaa caactcccag gcaaaccccc caaactcatc      120

atttatgacg tgaccaaccg gccctcaggc atttcaagtc gtttctctgg ctccatgtct      180

ggtcgcacgg cctccctgac aatctccggt ctccaggttg acgacgaggg tctctatcac      240

tgtgcctcac gtgaattttt cggcgggggg accaagctga ccgtcctgag tcagcccaag      300

gctgccccct cggtcactct gttcccaccc tcctctgagg agcttcaagc caacaaggcc      360

acactggtgt gtctcgtaag tgacttctac ccgggagccg tgacagtggc ctggaaggca      420

gatggcagcc ccgtcaaggt gggagtggag accaccaaac cctccaaaca aagcaacaac      480

aagtatgcgg ccagcagcta cctgagcctg acgcccgagc agtggaagtc ccacagaagc      540

tacagctgcc gggtcacgca tgaagggagc accgtggaga agacagtggc ccctgcagaa      600

tgctct                                                                 606


<210>  385
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  385

His Val Gln Leu Met Gln Ser Gly Thr Gln Ala Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Glu Thr Ala Gly Phe Lys Phe Ile Asp Ser 
            20                  25                  30          


Val Ile His Trp Leu Arg Gln Ala Pro Gly Gly Gly Phe Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Gly Gly Ala Val Asn Tyr Pro Pro Tyr Leu 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Arg Asp Leu Ser Thr Asp Thr Ile Tyr 
65                  70                  75                  80  


Met Val Leu Asn Gly Leu Thr Pro Ala Asp Thr Gly Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Phe Gly Gly Gly Ser Pro Phe Gly Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  386
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  386
cacgtgcaat tgatgcagtc tgggactcag gcgaagaagt ctggggcctc ggtgacaatt       60

tcttgtgaga ccgctggatt caagttcatc gactccgtca tacactggct gcgccaggcc      120

cctggagggg gatttcagtg gatggggtgg atcaagcctc ttggaggtgc cgtcaactat      180

ccaccctatt tgcagggcag gatctccttg acccgtgact tgtccaccga cacaatttac      240

atggtcttga atggactgac acctgccgac acaggctttt attactgcgc caaaggggcc      300

tttggggggg gttctccctt tggcttctgg ggccagggga ctctgctcac cgtctcccca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  387
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  387

Gln Ser Ala Leu Ser Gln Pro Val Ser Val Ser Gly Ser Pro Gly Asp 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Phe Gly Ala Thr Thr Trp Tyr Gln Gln Leu 
            20                  25                  30          


Pro Gly Arg Pro Pro Lys Leu Ile Ile Tyr Asp Val Thr Asn Arg Pro 
        35                  40                  45              


Ser Gly Ile Ser Gly Arg Phe Ser Gly Ser Met Ser Gly Gln Lys Ala 
    50                  55                  60                  


Ser Leu Thr Ile Ser Gly Leu Gln Val Asp Asp Glu Gly Leu Tyr His 
65                  70                  75                  80  


Cys Ala Ser Arg Glu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            100                 105                 110         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
        115                 120                 125             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
    130                 135                 140                 


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
145                 150                 155                 160 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                165                 170                 175     


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
            180                 185                 190         


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200         


<210>  388
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  388
cagtctgccc tgtctcagcc tgtctccgtg tctgggtctc ctggagactc gatcaccatt       60

tcttgttttg gagccaccac ctggtatcaa caactcccag gcagaccccc caaactcatc      120

atttatgacg tgactaaccg gccctcaggc atttcaggtc gtttctctgg ctccatgtct      180

ggtcaaaagg cctccctgac aatctccggt ctccaggttg acgacgaggg tctctatcac      240

tgcgcctcac gtgaattttt cggcgggggg accaaactga ccgtcctgag tcagcccaag      300

gctgccccct cggtcactct gttcccaccc tcctctgagg agcttcaagc caacaaggcc      360

acactggtgt gtctcgtaag tgacttctac ccgggagccg tgacagtggc ctggaaggca      420

gatggcagcc ccgtcaaggt gggagtggag accaccaaac cctccaaaca aagcaacaac      480

aagtatgcgg ccagcagcta cctgagcctg acgcccgagc agtggaagtc ccacagaagc      540

tacagctgcc gggtcacgca tgaagggagc accgtggaga agacagtggc ccctgcagaa      600

tgctct                                                                 606


<210>  389
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  389

His Val Gln Leu Arg Gln Ser Gly Thr Glu Ala Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Glu Thr Ala Gly Phe Asn Phe Ile Asp Ser 
            20                  25                  30          


Val Ile His Trp Leu Arg Gln Ala Pro Gly Gly Gly Phe Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Leu Arg Gly Gly Val Asn Tyr Pro His Tyr Leu 
    50                  55                  60                  


Gln Gly Arg Ile Ser Met Thr Arg Asp Leu Ser Ser Asp Thr Val Tyr 
65                  70                  75                  80  


Met Val Leu Asn Arg Leu Thr Pro Asp Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Phe Gly Gly Ser Ser Pro Phe Gly Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Leu Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  390
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  390
cacgtgcagt tgaggcagtc tgggactgag gcgaagaagt ctggggcctc ggtgacaatc       60

tcttgtgaga ccgctggatt caacttcatc gactccgtca tacactggct gcgccaggcc      120

cctggtgggg gatttcagtg gatggggtgg atcaagcctc ttagaggtgg cgtcaattat      180

ccacattatt tgcagggcag aatctccatg acccgggact tgtccagtga cacggtttac      240

atggtcttaa atagactgac acctgacgac acaggccttt actactgcgc gaaaggggcc      300

tttgggggga gttctccctt tggcttctgg ggccagggaa ctctgctcac cgtctcccca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  391
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  391

Gln Ser Ala Leu Ser Gln Pro Val Ser Val Ser Gly Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Glu Ala Thr Thr Trp Tyr Gln Gln Leu 
            20                  25                  30          


Pro Gly Arg Ser Pro Lys Leu Ile Ile Tyr Asp Val Thr Asn Arg Pro 
        35                  40                  45              


Ser Gly Ile Ser Ser Arg Phe Ser Gly Ser Met Ser Gly Arg Thr Ala 
    50                  55                  60                  


Ser Leu Thr Ile Ser Gly Leu Gln Val Asp Asp Glu Gly Leu Tyr His 
65                  70                  75                  80  


Cys Ala Ser Arg Glu Phe Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                85                  90                  95      


Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            100                 105                 110         


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
        115                 120                 125             


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
    130                 135                 140                 


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
145                 150                 155                 160 


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
                165                 170                 175     


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
            180                 185                 190         


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200         


<210>  392
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  392
cagtctgccc tgtctcagcc tgtctccgtg tctgggtctc ctggagagtc gatcaccatt       60

tcctgtactg aagccaccac ctggtatcaa caactcccag ggagatcccc caaactcatt      120

atttatgacg tgaccaaccg gccctcaggc atttcaagtc gtttctctgg ctccatgtct      180

ggtcgcacgg cctccctgac aatctccggt ctccaggttg acgacgaggg tctctatcac      240

tgtgcctcac gtgaattttt cggcgggggg accaagctga ccgtcctcag tcagcccaag      300

gctgccccct cggtcactct gttcccaccc tcctctgagg agcttcaagc caacaaggcc      360

acactggtgt gtctcgtaag tgacttctac ccgggagccg tgacagtggc ctggaaggca      420

gatggcagcc ccgtcaaggt gggagtggag accaccaaac cctccaaaca aagcaacaac      480

aagtatgcgg ccagcagcta cctgagcctg acgcccgagc agtggaagtc ccacagaagc      540

tacagctgcc gggtcacgca tgaagggagc accgtggaga agacagtggc ccctgcagaa      600

tgctct                                                                 606


<210>  393
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  393

Arg Val Thr Leu Gln Gln Ser Gly Ala Thr Val Arg Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Glu Thr Ser Gly Phe Thr Phe Ile Lys Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Arg Ile His Pro Arg Thr Gly Ala Val Lys Phe Ala Pro Ile Phe 
    50                  55                  60                  


Gln Gly Lys Phe Ser Met Ser Arg Asp Leu Ser Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Thr Arg Leu Thr Leu Ala Asp Thr Ala Leu Phe Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Phe Glu Ala Asp Leu Tyr Gly Pro Thr Tyr Pro Phe 
            100                 105                 110         


His His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ala Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  394
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  394
cgtgttacat tacaacagtc tggggctaca gtgaggcagc ctggggcctc agtcaccgtc       60

tcctgcgaga cttctggatt caccttcatc aaatatacca ttcactgggt gcgacaggcc      120

cctggacagg gtcttcagtg ggtgggaaga atacaccccc gaaccggtgc cgtgaagttt      180

gcaccgatat ttcagggtaa attttccatg agtcgagact tgtcacgcga cacagcctac      240

ctcggattga ccagactgac actcgccgac acggctctat ttttctgtgc gaggggggcc      300

tttgaggcag atttatatgg gccaacttac ccctttcacc actggggcca aggaacccaa      360

gtcaccgtct ccgcggcctc caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1365


<210>  395
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  395

Ser Trp Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Met Ser Cys Thr Gly Phe Gly Ser Tyr Asn Pro Asp Ser 
            20                  25                  30          


Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
        35                  40                  45              


Asp Asn Lys Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Ala Ser Arg 
    50                  55                  60                  


Leu Gly Ser Thr Ser Ser Leu Thr Ile Ser Asn Val Gln Ala Ala Asp 
65                  70                  75                  80  


Asp Ala His Tyr Val Cys Ala Ser Phe Glu Phe Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
            100                 105                 110         


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
        115                 120                 125             


Cys Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
    130                 135                 140                 


Ala Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser 
145                 150                 155                 160 


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
                165                 170                 175     


Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His 
            180                 185                 190         


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205         


<210>  396
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  396
tcctgggccc tgactcaacc cgcctccgtg tctgcgtctc ctgggcagtc ggtcaccatg       60

tcctgcactg gattcggaag ttataatcct gactcctggt accagcaata cccaggcaaa      120

gcccccaaac tcatcattta tgatgacaat aaaagaccct cgggggtctc tgatcgcttc      180

tctgcctcca gacttggcag cacatcttca ctgacaatct ctaacgtcca ggccgctgac      240

gacgcccatt atgtctgcgc ctcctttgag tttttcggcg gggggaccaa gctgaccgtc      300

ctgagtcagc ccaaggctgc cccctcggtc actctgttcc caccctcctc tgaggagctt      360

caagccaaca aggccacact ggtgtgtctc gtaagtgact tctacccggg agccgtgaca      420

gtggcctgga aggcagatgg cagccccgtc aaggtgggag tggagaccac caaaccctcc      480

aaacaaagca acaacaagta tgcggccagc agctacctga gcctgacgcc cgagcagtgg      540

aagtcccaca gaagctacag ctgccgggtc acgcatgaag ggagcaccgt ggagaagaca      600

gtggcccctg cagaatgctc t                                                621


<210>  397
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  397

His Ile Gln Leu Leu Gln Ser Gly Pro Gln Val Lys Lys Ser Gly Asp 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Asn Phe Val Asp Ser 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu Gln Gly Gly Val Asn Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ile Arg Met Thr Arg Asp Thr Phe Ile Asp Thr Val Tyr 
65                  70                  75                  80  


Val Asp Leu Ser Gly Leu Thr Pro Ala Asp Thr Ala Tyr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Asp Gly Asn Ser Tyr Pro Phe His Phe Trp Gly His 
            100                 105                 110         


Gly Thr Arg Val Thr Val Phe Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  398
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  398
cacattcagt tgctacagtc ggggcctcaa gttaagaagt ctggggacac agtgagaatc       60

tcctgtgaga cctctggata taatttcgtc gactccctta tccactgggt ccgacagacc      120

ccggaaaaac gtctcagatg gatgggctgg atcaatcctc tccaaggtgg tgtgaattac      180

gcgccggaat ttcagggcag aatcaggatg accagggaca cgtttataga cacagtttac      240

gtggacttga gcggactgac accggccgac acggcctatt attactgcgc gcgagggatc      300

gatggcaatt cttacccctt tcatttctgg ggccacggaa cccgggtcac cgtcttctcg      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  399
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  399

Arg Phe Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ile Thr Ile Thr Cys Ala Gly Gly Ser Val Ser Trp Phe His Phe 
            20                  25                  30          


Pro Pro Gly Lys Thr Pro Arg Leu Ile Ile Tyr Glu Ser Ser Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Ser Pro Arg Phe Ser Gly Ser Gln Ser Gly Ser Thr 
    50                  55                  60                  


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ser Asp Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Phe Cys Ser Ile Leu Glu Phe Phe Gly Arg Gly Thr Leu Leu Thr Val 
                85                  90                  95      


Leu Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
            100                 105                 110         


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser 
        115                 120                 125             


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
    130                 135                 140                 


Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
145                 150                 155                 160 


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
                165                 170                 175     


Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr 
            180                 185                 190         


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200             


<210>  400
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody variant

<400>  400
cgatttgccc tgactcaacc tgcctccgtg tctgggtctc ctggacagac gatcaccata       60

acctgcgctg gaggcagcgt ctcctggttc catttccctc caggcaaaac ccccagactc      120

attatttatg agtcttctaa gagaccctca ggggtctctc ctcgattctc tgggtcccag      180

tctggcagca cggcctccct aataatttct ggcctccagt ctgatgacga agggacatac      240

ttctgttcta ttcttgaatt tttcggcaga gggactcttc tcaccgtcct gagtcagccc      300

aaggctgccc cctcggtcac tctgttccca ccctcctctg aggagcttca agccaacaag      360

gccacactgg tgtgtctcgt aagtgacttc tacccgggag ccgtgacagt ggcctggaag      420

gcagatggca gccccgtcaa ggtgggagtg gagaccacca aaccctccaa acaaagcaac      480

aacaagtatg cggccagcag ctacctgagc ctgacgcccg agcagtggaa gtcccacaga      540

agctacagct gccgggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctgca      600

gaatgctct                                                              609


<210>  401
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  401

Gly Tyr Asp Phe Ile Asp Tyr Val 
1               5               


<210>  402
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  402

Met Asn Pro Ser Gly Gly Gly Thr 
1               5               


<210>  403
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  403

Val Arg Asp Arg Ala Asn Gly Ser Gly Arg Arg Arg Phe Glu Ser Val 
1               5                   10                  15      


Asn Trp Phe Leu Asp Leu 
            20          


<210>  404
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  404

Trp Ala Phe Glu Asn 
1               5   


<210>  405
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  405

Gly Tyr Lys Phe Pro Asp Tyr Ile 
1               5               


<210>  406
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  406

Ile Asn Pro Met Gly Gly Gln Val 
1               5               


<210>  407
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  407

Val Arg Asp Arg Ser Asn Gly Ser Gly Arg Arg Phe Glu Ser Ser Asn 
1               5                   10                  15      


<210>  408
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  408

Trp Ala Tyr Glu Ala 
1               5   


<210>  409
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  409

Gly Tyr Thr Phe Thr Asp Tyr Leu 
1               5               


<210>  410
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  410

Met Asn Pro Val Tyr Gly Gln Val 
1               5               


<210>  411
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  411

Val Arg Asp Thr Gly Asp Gly Ser Arg Arg His Phe Asp Ser Ile Asn 
1               5                   10                  15      


Trp Phe Leu Asp Leu 
            20      


<210>  412
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  412

Trp Ala Phe Glu Ala 
1               5   


<210>  413
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  413

Gly Tyr Thr Phe Thr Asp Tyr Val 
1               5               


<210>  414
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  414

Ile Asp Pro Pro Tyr Gly Gln Val 
1               5               


<210>  415
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  415

Val Arg Asp Arg Ser Asn Gly Trp Gly Lys Arg Phe Glu Ser Ser Asn 
1               5                   10                  15      


Trp Phe Leu Asp Leu 
            20      


<210>  416
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  416

Gly Tyr Thr Phe Val Asp Tyr Phe 
1               5               


<210>  417
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  417

Met Asp Pro Leu Asn Gly Arg Pro 
1               5               


<210>  418
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  418

Val Arg Asp Lys Ser Asn Gly Ser Gly Arg Arg Phe Asp Ser Ser Asn 
1               5                   10                  15      


Trp Phe Leu Asp Leu 
            20      


<210>  419
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  419

Trp Ala Tyr Asp Ala 
1               5   


<210>  420
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  420

Gly Tyr Thr Phe Ser Asp Tyr Ile 
1               5               


<210>  421
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  421

Met Asn Pro Met Gly Gly Gln Val 
1               5               


<210>  422
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  422

Trp Ala Tyr Glu Val 
1               5   


<210>  423
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  423

Gly Tyr Thr Phe Ile Asp Tyr Ile 
1               5               


<210>  424
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  424

Ile Asp Pro Met Asn Gly Arg Pro 
1               5               


<210>  425
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  425

Val Arg Asp Lys Ser Asn Gly Ser Gly Lys Arg Phe Asp Ser Ser Asn 
1               5                   10                  15      


Trp Phe Leu Asp Leu 
            20      


<210>  426
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  426

Gly Tyr Thr Phe Thr Asp Tyr Ile 
1               5               


<210>  427
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  427

Met Asn Pro Met Gly Gly Arg Thr 
1               5               


<210>  428
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  428

Gly Tyr Thr Phe Val Asp Tyr Leu 
1               5               


<210>  429
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  429

Met Asp Pro Met Asn Gly Arg Pro 
1               5               


<210>  430
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  430

Val Arg Asp Lys Ser Gly Gly Ser Gly Lys Leu Phe Asp Ser Ser Asn 
1               5                   10                  15      


Trp Phe Leu Asp Leu 
            20      


<210>  431
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  431

Ile Asn Pro Gly Tyr Gly Gln Val 
1               5               


<210>  432
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  432

Met Asp Pro Ser Tyr Gly Gln Val 
1               5               


<210>  433
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  433

Val Arg Asp Arg Ser His Gly Ser Gly Arg Gln Phe Glu Ser Ser Asn 
1               5                   10                  15      


Trp Phe Leu Asp Leu 
            20      


<210>  434
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  434

Met Asp Pro Ser Phe Gly Gln Met 
1               5               


<210>  435
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  435

Val Arg Asp Arg Ser His Gly Ser Gly Arg Leu Phe Glu Ser Ser Asn 
1               5                   10                  15      


Trp Phe Leu Asp Leu 
            20      


<210>  436
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  436

Gly Tyr Arg Phe Thr Asp Tyr Val 
1               5               


<210>  437
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  437

Met Asp Pro Ser Phe Gly Arg Met 
1               5               


<210>  438
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  438

Gly Tyr Thr Phe Ile Asp Tyr Val 
1               5               


<210>  439
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  439

Met Asp Pro Thr Tyr Gly Arg Met 
1               5               


<210>  440
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  440

Gly Tyr Arg Phe Leu Asp Tyr Ile 
1               5               


<210>  441
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  441

Val Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn 
1               5                   10                  15      


Trp Phe Leu Asp Leu 
            20      


<210>  442
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  442

Gly Tyr Lys Phe Met Asp Gln Leu 
1               5               


<210>  443
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  443

Met Asn Pro Thr Tyr Gly Gln Val 
1               5               


<210>  444
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  444

Ala Arg Gly Pro Ser Gly Glu Asn Tyr Pro Phe His Tyr 
1               5                   10              


<210>  445
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  445

Arg His Ile Ile 
1               


<210>  446
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  446

Asn Thr Tyr Glu Phe 
1               5   


<210>  447
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  447

Gly Tyr Asn Phe Val Asp Ser Arg 
1               5               


<210>  448
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  448

Ile Asn Pro Leu Gln Gly Gly Val 
1               5               


<210>  449
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  449

Ala Arg Gly Ile Asp Gly Lys Ser Tyr Pro Phe His Phe 
1               5                   10              


<210>  450
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  450

Ser Ile Leu Glu Phe 
1               5   


<210>  451
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  451

Gly Tyr Thr Phe Thr Lys Tyr Phe 
1               5               


<210>  452
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  452

Ile His Pro Arg Thr Gly Ala Val 
1               5               


<210>  453
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  453

Ala Arg Gly Ala Phe Glu Ala Asp Ser Tyr Gly Ser Ser Tyr Pro Phe 
1               5                   10                  15      


His His 
        


<210>  454
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  454

Gly Asn Tyr Asn Pro 
1               5   


<210>  455
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  455

Ala Ser Phe Glu Phe 
1               5   


<210>  456
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  456

Gly Tyr Thr Phe Thr Lys Tyr Thr 
1               5               


<210>  457
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  457

Ala Arg Gly Ala Phe Glu Ala Asp Leu Ser Gly Pro Thr Tyr Pro Phe 
1               5                   10                  15      


His His 
        


<210>  458
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  458

Gly Phe Asn Phe Ile Asp Ser Val 
1               5               


<210>  459
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  459

Ile Lys Pro Leu Arg Gly Ala Val 
1               5               


<210>  460
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  460

Ala Lys Gly Ala Phe Arg Gly Gly Ser Pro Phe Gly Phe 
1               5                   10              


<210>  461
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  461

Ala Ser Arg Glu Phe 
1               5   


<210>  462
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  462

Met Asn Pro Met Thr Gly Gln Met 
1               5               


<210>  463
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  463

Ala Arg Gly Asp Phe Gly Gln Asn Tyr Pro Phe His Tyr 
1               5                   10              


<210>  464
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  464

Asn Arg Tyr Leu 
1               


<210>  465
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  465

Ala Ser Tyr Glu Arg 
1               5   


<210>  466
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  466

Gly Tyr Asn Phe Met Asp Gln Phe 
1               5               


<210>  467
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  467

Met Asn Pro Ile Tyr Gly Gln Val 
1               5               


<210>  468
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  468

Ile Asn Pro Leu His Gly Gly Val 
1               5               


<210>  469
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  469

Gly Tyr Thr Phe Thr Ser Tyr Phe 
1               5               


<210>  470
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  470

Ile Asn Pro Leu His Gly Ala Val 
1               5               


<210>  471
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  471

Thr Arg Gly Ile Val Ala Asp Gly Trp Pro Tyr Gly His 
1               5                   10              


<210>  472
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  472

Ser Ser Leu Gln Phe 
1               5   


<210>  473
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  473

Gly Phe Thr Phe Ile Asp His Ile 
1               5               


<210>  474
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  474

Cys Lys Ala Ala Ala Pro Glu Glu Ala Phe Pro Leu Gln Tyr 
1               5                   10                  


<210>  475
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  475

Ser Ser Arg Thr Phe 
1               5   


<210>  476
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  476

Gly Phe Lys Phe Ile Asp His Ile 
1               5               


<210>  477
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  477

Ile Lys Pro Leu Gly Gly Val Ala 
1               5               


<210>  478
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  478

Cys Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Tyr 
1               5                   10                  


<210>  479
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  479

Ser Ser Thr Thr Phe 
1               5   


<210>  480
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  480

Gly Phe Ala Phe Leu Asp His 
1               5           


<210>  481
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  481

Val Lys Thr Ile Gly Gly Val Val 
1               5               


<210>  482
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  482

Ser Lys Ala Ala Ala Pro Asp Glu Ala Phe Pro Leu Glu Phe 
1               5                   10                  


<210>  483
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  483

Gly Phe Lys Phe Thr Glu Tyr Phe 
1               5               


<210>  484
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  484

Leu Asn Pro Leu Arg Gly Ala Val 
1               5               


<210>  485
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  485

Ala Arg Ala Val Phe Asn Glu Ala Phe Pro Phe Asp Tyr 
1               5                   10              


<210>  486
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  486

Gly Phe Ala Phe Leu Asp His Ile 
1               5               


<210>  487
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  487

Gly Phe Lys Phe Ile Asp Ser Val 
1               5               


<210>  488
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  488

Ile Lys Pro Leu Gly Gly Ala Val 
1               5               


<210>  489
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  489

Ala Lys Gly Ala Phe Gly Gly Gly Ser Pro Phe Gly Phe 
1               5                   10              


<210>  490
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  490

Ile Lys Pro Leu Arg Gly Gly Val 
1               5               


<210>  491
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  491

Ala Lys Gly Ala Phe Gly Gly Ser Ser Pro Phe Gly Phe 
1               5                   10              


<210>  492
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  492

Gly Phe Thr Phe Ile Lys Tyr Thr 
1               5               


<210>  493
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  493

Ala Arg Gly Ala Phe Glu Ala Asp Leu Tyr Gly Pro Thr Tyr Pro Phe 
1               5                   10                  15      


His His 
        


<210>  494
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  494

Gly Ser Tyr Asn Pro 
1               5   


<210>  495
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  495

Gly Tyr Asn Phe Val Asp Ser Leu 
1               5               


<210>  496
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  496

Ala Arg Gly Ile Asp Gly Asn Ser Tyr Pro Phe His Phe 
1               5                   10              


<210>  497
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  497

Gly Tyr Arg Phe Pro Asp Tyr Ile 
1               5               


<210>  498
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  498

Val Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn 
1               5                   10                  15      


<210>  499
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  499

Asn Thr Tyr Glu Phe Phe 
1               5       


<210>  500
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  500

Gly Tyr Thr Phe Thr Thr His His Gly His Phe 
1               5                   10      


<210>  501
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  501

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp Pro 
65                  70                  75                  80  


Asp Trp Gly Thr Ala Phe Leu Asp Leu Arg Gly Leu Lys Ser Asp Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Val Arg Asp Arg Ser Asn Gly Ser Gly Lys 
            100                 105                 110         


Arg Phe Glu Ser Ser Asn Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr 
        115                 120                 125             


Ala Val Thr Ile Gln Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  502
<211>  1392
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  502
gcggacttgg tgcagtctgg ggctgtggtg aagaagcctg gggactcagt gaggatctcc       60

tgtgaggctc aaggatatag atttcctgac tacatcattc actggattcg acgggcccct      120

ggacaaggcc ctgaatggat gggatggatg aatccaatgg gcggacaagt aaatattcca      180

tggaaatttc agggtagggt ctccatgacc cggcaattat ctcaagaccc agacgacccg      240

gactggggca cagcatttct ggacttaaga ggactaaagt ctgacgacac ggccgtctat      300

tattgcgtga gagatcgcag taatggatcg ggaaagcgat tcgagtcctc caattggttc      360

ctcgatctgt ggggccgtgg gactgcggtc acaattcaat cagcctccac caagggccca      420

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      480

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      540

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      600

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      660

cacaagccca gcaacaccaa ggtggacaag agagttgagc ccaaatcttg tgacaaaact      720

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      780

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      840

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      900

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgggtggtc      960

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1020

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1080

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1140

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1200

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1260

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1380

tctccgggta aa                                                         1392


<210>  503
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  503

Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        195                 200                 205 


<210>  504
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  504
gccc tgactcagcc tcgctcagtg tccgcatctc ctgggcagtc cgtcaccatt       60

tcctgcactg gaacccacaa tttggtctct tggtgtcaac atcagccagg cagagccccc      120

aaattattaa tttatgactt caataagagg ccctcagggg tccctgatcg cttctctggc      180

tccgggtctg gcggcacggc ctccctgacc atcactggac tccaggatga cgatgacgcc      240

gaatattttt gttgggcgta tgaagctttt ggcggaggga ccaagttgac cgttcttggt      300

cagcccaagg ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc      360

aacaaggcca cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggct      420

tggaaagcag atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa      480

agcaacaaca agtacgcggc cagcagctat ctgagcctga cgcctgagca gtggaagtcc      540

cacagaagct acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc      600

cctacagaat gttca                                                       615


<210>  505
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  505

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Thr Gly Tyr Lys Phe Met Asp Gln 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Thr Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  506
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  506
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgactggata taaattcatg gaccaactca taaactgggt gcggcaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaatccaa catatggaca agtaaattat      180

tcatggagat ttgaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  507
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  507

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Pro 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  508
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  508
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc accctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  509
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  509

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  510
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  510
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc agcgtccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  511
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  511

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  512
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  512
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  513
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  513

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Trp Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  514
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  514
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatggggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc agcgtccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  515
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  515

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  516
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Antibody light chain

<400>  516
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  517
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody heavy chain

<400>  517

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Phe Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  518
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  518
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatttggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc agcgtccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  519
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  519

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  520
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  520
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  521
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  521

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Leu Phe Ser Gln Asp Leu Tyr Tyr 
65                  70                  75                  80  


Pro Asp Arg Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  522
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  522
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggctat tctctcaaga cctatactac      240

ccggaccggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc agcgtccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  523
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  523

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  524
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  524
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  525
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  525

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asp Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  526
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  526
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata cgacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc agcgtccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  527
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  527

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  528
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  528
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  529
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  529

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asp Phe Ile Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  530
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  530
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata cgacttcatt gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc agcgtccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  531
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  531

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  532
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  532
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  533
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  533

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  534
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  534
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc agcgtccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gctgcatgag     1320

gctctgcaca gccactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  535
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  535

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  536
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  536
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  537
<211>  457
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  537

His Val Gln Leu Val Gln Ser Gly Gly Gly Val Lys Lys Ile Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Glu Val Ser Gly Tyr Asn Phe Met Asp Gln 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Ile Tyr Gly Gln Val Asn Tyr Ser Trp Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Gln Leu Ser Gln Asp Pro Asp Asp 
65                  70                  75                  80  


Pro Asp Trp Gly Thr Ala Phe Met Glu Leu Arg Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Pro Ser Gly Glu Asn Tyr 
            100                 105                 110         


Pro Phe His Tyr Trp Gly Gln Gly Val Arg Val Val Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  538
<211>  1371
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody heavy chain

<400>  538
cacgtccaat tggtgcagtc tggaggtggg gtgaagaaga ttggggccgc tgtgaggatc       60

tcctgcgagg tgtctggata caacttcatg gaccaattca taaattgggt gcgacaggcc      120

cccggtcagg gccttgagtg gatgggatgg atgaacccaa tatatggaca agtaaattat      180

tcatggagat ttcaaggaag ggtcaccatg accaggcaat tatctcaaga cccagacgac      240

ccggactggg gcacggcctt catggagttg agaggactga gagtggacga cacggccgtc      300

tattattgcg cgaggggacc ctctggggaa aattatcctt ttcactattg gggccagggt      360

gtccgagtgg tcgtctcgtc agcgtccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctctatatca cccgggagcc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1371


<210>  539
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  539

Leu Thr Gln Pro Ala Ser Met Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Thr Arg His Ile Ile Ser Ala Trp 
            20                  25                  30          


Phe Gln Gln Tyr Pro Gly Lys Pro Pro Lys Leu Ile Ile Phe Asp Asp 
        35                  40                  45              


Asp Lys Arg Pro Ser Gly Val Pro Ser Arg Phe Ser Ala Ser Arg Pro 
    50                  55                  60                  


Gly Asp Thr Ala Ser Leu Thr Ile Ser Asn Val Gln Pro Glu Asp Glu 
65                  70                  75                  80  


Ala Thr Tyr Ile Cys Asn Thr Tyr Glu Phe Phe Gly Gly Gly Thr Lys 
                85                  90                  95      


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
            100                 105                 110         


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
        115                 120                 125             


Leu Val Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
    130                 135                 140                 


Asp Gly Ser Pro Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys 
145                 150                 155                 160 


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
                165                 170                 175     


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu 
            180                 185                 190         


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
        195                 200                 205     


<210>  540
<211>  609
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody light chain

<400>  540
c tgactcagcc tgcctccatg tctgcgtccc ctggacagtc ggtaaccatc       60

tcgtgctctg gaaccagaca cataatctct gcttggttcc aacaatatcc aggcaaacca      120

cccaaactca taatttttga cgacgataag cgtccctctg gagttcctag tcgcttctct      180

gcctccaggc ctggcgacac ggcctccctg acaatctcta atgttcaacc tgaggacgag      240

gcgacataca tttgcaatac atatgaattc tttggcggag ggaccaaatt gaccgtccta      300

ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa      360

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      420

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      480

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      540

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      600

gcccctgcag aatgctct                                                    618


<210>  541
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain sequence

<400>  541

Gln Leu Ser Gln Asp Pro Asp Asp Pro Asp Trp Gly 
1               5                   10          


<210>  542
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  antibody heavy chain sequence

<400>  542

Leu Phe Ser Gln Asp Leu Tyr Tyr Pro Asp Arg Gly 
1               5                   10          


<210>  543
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  543

Met Asn Pro Ile Trp Gly Gln Val 
1               5               


<210>  544
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  544

Met Asn Pro Ile Phe Gly Gln Val 
1               5               


<210>  545
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  545

Gly Tyr Asp Phe Met Asp Gln Phe 
1               5               


<210>  546
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR

<400>  546

Gly Tyr Asp Phe Ile Asp Gln Phe 
1               5               




