                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  CD19 AND CD22 CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

<130>  PAT058691-WO-PCT

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgaaattg tgatgaccca gtcacccgcc actcttagcc tttcacccgg tgagcgcgca      120

accctgtctt gcagagcctc ccaagacatc tcaaaatacc ttaattggta tcaacagaag      180

cccggacagg ctcctcgcct tctgatctac cacaccagcc ggctccattc tggaatccct      240

gccaggttca gcggtagcgg atctgggacc gactacaccc tcactatcag ctcactgcag      300

ccagaggact tcgctgtcta tttctgtcag caagggaaca ccctgcccta cacctttgga      360

cagggcacca agctcgagat taaaggtgga ggtggcagcg gaggaggtgg gtccggcggt      420

ggaggaagcc aggtccaact ccaagaaagc ggaccgggtc ttgtgaagcc atcagaaact      480

ctttcactga cttgtactgt gagcggagtg tctctccccg attacggggt gtcttggatc      540

agacagccac cggggaaggg tctggaatgg attggagtga tttggggctc tgagactact      600

tactaccaat catccctcaa gtcacgcgtc accatctcaa aggacaactc taagaatcag      660

gtgtcactga aactgtcatc tgtgaccgca gccgacaccg ccgtgtacta ttgcgctaag      720

cattactatt atggcgggag ctacgcaatg gattactggg gacagggtac tctggtcacc      780

gtgtccagct tggcagaagc cgccgcgaaa gaagtgcagc ttcaacaatc aggaccagga      840

ctcgtcaaac catcacagac cctctccctc acatgtgcca tctccgggga ctccatgttg      900

agcaattccg acacttggaa ttggattaga caaagcccgt cccggggtct ggaatggttg      960

ggacgcacct accaccggtc tacttggtac gacgactacg cgtcatccgt gcggggaaga     1020

gtgtccatca acgtggacac ctccaagaac cagtacagcc tgcagcttaa tgccgtgact     1080

cctgaggata cgggcgtcta ctactgcgcc cgcgtccgcc tgcaagacgg gaacagctgg     1140

agcgatgcat tcgatgtctg gggccaggga actatggtca ccgtgtcgtc tgggggcggt     1200

ggatcgggtg gcgggggttc ggggggcggc ggctctcagt ccgctcttac ccaaccggcc     1260

tcagcctcgg ggagccccgg ccagagcgtg accatttcct gcaccggcac ttcatccgac     1320

gtgggcggct acaactacgt gtcctggtac caacagcacc cgggaaaggc ccccaagctc     1380

atgatctacg acgtgtccaa caggccctcg ggagtgtcca accggttctc gggttcgaaa     1440

tcgggaaaca cagccagcct gaccatcagc ggactgcagg ctgaagatga agccgactac     1500

tactgctcct cctacacctc gtcatccacg ctctacgtgt tcggcactgg aactcagctg     1560

actgtgctga ccactacccc agcaccgagg ccacccaccc cggctcctac catcgcctcc     1620

cagcctctgt ccctgcgtcc ggaggcatgt agacccgcag ctggtggggc cgtgcatacc     1680

cggggtcttg acttcgcctg cgatatctac atttgggccc ctctggctgg tacttgcggg     1740

gtcctgctgc tttcactcgt gatcactctt tactgtaagc gcggtcggaa gaagctgctg     1800

tacatcttta agcaaccctt catgaggcct gtgcagacta ctcaagagga ggacggctgt     1860

tcatgccggt tcccagagga ggaggaaggc ggctgcgaac tgcgcgtgaa attcagccgc     1920

agcgcagatg ctccagccta ccagcagggg cagaaccagc tctacaacga actcaatctt     1980

ggtcggagag aggagtacga cgtgctggac aagcggagag gacgggaccc agaaatgggc     2040

gggaagccgc gcagaaagaa tccccaagag ggcctgtaca acgagctcca aaaggataag     2100

atggcagaag cctatagcga gattggtatg aaaggggaac gcagaagagg caaaggccac     2160

gacggactgt accagggact cagcaccgcc accaaggaca cctatgacgc tcttcacatg     2220

caggccctgc cgcctcgg                                                   2238


<210>  2
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Leu Ala Glu Ala Ala Ala Lys Glu Val 
            260                 265                 270         


Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
        275                 280                 285             


Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Met Leu Ser Asn Ser Asp 
    290                 295                 300                 


Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
305                 310                 315                 320 


Gly Arg Thr Tyr His Arg Ser Thr Trp Tyr Asp Asp Tyr Ala Ser Ser 
                325                 330                 335     


Val Arg Gly Arg Val Ser Ile Asn Val Asp Thr Ser Lys Asn Gln Tyr 
            340                 345                 350         


Ser Leu Gln Leu Asn Ala Val Thr Pro Glu Asp Thr Gly Val Tyr Tyr 
        355                 360                 365             


Cys Ala Arg Val Arg Leu Gln Asp Gly Asn Ser Trp Ser Asp Ala Phe 
    370                 375                 380                 


Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
                405                 410                 415     


Thr Gln Pro Ala Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
            420                 425                 430         


Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
        435                 440                 445             


Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
    450                 455                 460                 


Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys 
465                 470                 475                 480 


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
                485                 490                 495     


Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr Leu Tyr 
            500                 505                 510         


Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu Thr Thr Thr Pro Ala 
        515                 520                 525             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    530                 535                 540                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
545                 550                 555                 560 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                565                 570                 575     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            580                 585                 590         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        595                 600                 605             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    610                 615                 620                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
625                 630                 635                 640 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                645                 650                 655     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            660                 665                 670         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        675                 680                 685             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    690                 695                 700                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
705                 710                 715                 720 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                725                 730                 735     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745     


<210>  3
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgaagtgc agcttcaaca atcaggacca ggactcgtca aaccatcaca gaccctctcc      120

ctcacatgtg ccatctccgg ggactccatg ttgagcaatt ccgacacttg gaattggatt      180

agacaaagcc cgtcccgggg tctggaatgg ttgggacgca cctaccaccg gtctacttgg      240

tacgacgact acgcgtcatc cgtgcgggga agagtgtcca tcaacgtgga cacctccaag      300

aaccagtaca gcctgcagct taatgccgtg actcctgagg atacgggcgt ctactactgc      360

gcccgcgtcc gcctgcaaga cgggaacagc tggagcgatg cattcgatgt ctggggccag      420

ggaactatgg tcaccgtgtc gtctgggggc ggtggatcgg gtggcggggg ttcggggggc      480

ggcggctctc agtccgctct tacccaaccg gcctcagcct cggggagccc cggccagagc      540

gtgaccattt cctgcaccgg cacttcatcc gacgtgggcg gctacaacta cgtgtcctgg      600

taccaacagc acccgggaaa ggcccccaag ctcatgatct acgacgtgtc caacaggccc      660

tcgggagtgt ccaaccggtt ctcgggttcg aaatcgggaa acacagccag cctgaccatc      720

agcggactgc aggctgaaga tgaagccgac tactactgct cctcctacac ctcgtcatcc      780

acgctctacg tgttcggcac tggaactcag ctgactgtgc tgggaggggg agggagtgaa      840

attgtgatga cccagtcacc cgccactctt agcctttcac ccggtgagcg cgcaaccctg      900

tcttgcagag cctcccaaga catctcaaaa taccttaatt ggtatcaaca gaagcccgga      960

caggctcctc gccttctgat ctaccacacc agccggctcc attctggaat ccctgccagg     1020

ttcagcggta gcggatctgg gaccgactac accctcacta tcagctcact gcagccagag     1080

gacttcgctg tctatttctg tcagcaaggg aacaccctgc cctacacctt tggacagggc     1140

accaagctcg agattaaagg tggaggtggc agcggaggag gtgggtccgg cggtggagga     1200

agccaggtcc aactccaaga aagcggaccg ggtcttgtga agccatcaga aactctttca     1260

ctgacttgta ctgtgagcgg agtgtctctc cccgattacg gggtgtcttg gatcagacag     1320

ccaccgggga agggtctgga atggattgga gtgatttggg gctctgagac tacttactac     1380

caatcatccc tcaagtcacg cgtcaccatc tcaaaggaca actctaagaa tcaggtgtca     1440

ctgaaactgt catctgtgac cgcagccgac accgccgtgt actattgcgc taagcattac     1500

tattatggcg ggagctacgc aatggattac tggggacagg gtactctggt caccgtgtcc     1560

agcaccacta ccccagcacc gaggccaccc accccggctc ctaccatcgc ctcccagcct     1620

ctgtccctgc gtccggaggc atgtagaccc gcagctggtg gggccgtgca tacccggggt     1680

cttgacttcg cctgcgatat ctacatttgg gcccctctgg ctggtacttg cggggtcctg     1740

ctgctttcac tcgtgatcac tctttactgt aagcgcggtc ggaagaagct gctgtacatc     1800

tttaagcaac ccttcatgag gcctgtgcag actactcaag aggaggacgg ctgttcatgc     1860

cggttcccag aggaggagga aggcggctgc gaactgcgcg tgaaattcag ccgcagcgca     1920

gatgctccag cctaccagca ggggcagaac cagctctaca acgaactcaa tcttggtcgg     1980

agagaggagt acgacgtgct ggacaagcgg agaggacggg acccagaaat gggcgggaag     2040

ccgcgcagaa agaatcccca agagggcctg tacaacgagc tccaaaagga taagatggca     2100

gaagcctata gcgagattgg tatgaaaggg gaacgcagaa gaggcaaagg ccacgacgga     2160

ctgtaccagg gactcagcac cgccaccaag gacacctatg acgctcttca catgcaggcc     2220

ctgccgcctc gg                                                         2232


<210>  4
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Met Leu Ser Asn Ser Asp Thr Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr His Arg Ser Thr Trp 
65                  70                  75                  80  


Tyr Asp Asp Tyr Ala Ser Ser Val Arg Gly Arg Val Ser Ile Asn Val 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn Ala Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Val Arg Leu Gln Asp Gly 
        115                 120                 125             


Asn Ser Trp Ser Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser Gly Ser 
                165                 170                 175     


Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val 
            180                 185                 190         


Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala 
        195                 200                 205             


Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser 
    210                 215                 220                 


Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile 
225                 230                 235                 240 


Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr 
                245                 250                 255     


Thr Ser Ser Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr 
            260                 265                 270         


Val Leu Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
        275                 280                 285             


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
    290                 295                 300                 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
305                 310                 315                 320 


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
                325                 330                 335     


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
            340                 345                 350         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
        355                 360                 365             


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
    370                 375                 380                 


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
                405                 410                 415     


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
            420                 425                 430         


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        435                 440                 445             


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu 
    450                 455                 460                 


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
465                 470                 475                 480 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
            500                 505                 510         


Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
        515                 520                 525             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    530                 535                 540                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
545                 550                 555                 560 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                565                 570                 575     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            580                 585                 590         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        595                 600                 605             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    610                 615                 620                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
625                 630                 635                 640 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                645                 650                 655     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            660                 665                 670         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        675                 680                 685             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    690                 695                 700                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
705                 710                 715                 720 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                725                 730                 735     


His Met Gln Ala Leu Pro Pro Arg 
            740                 


<210>  5
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccccagtccg ctcttaccca accggcctca gcctcgggga gccccggcca gagcgtgacc      120

atttcctgca ccggcacttc atccgacgtg ggcggctaca actacgtgtc ctggtaccaa      180

cagcacccgg gaaaggcccc caagctcatg atctacgacg tgtccaacag gccctcggga      240

gtgtccaacc ggttctcggg ttcgaaatcg ggaaacacag ccagcctgac catcagcgga      300

ctgcaggctg aagatgaagc cgactactac tgctcctcct acacctcgtc atccacgctc      360

tacgtgttcg gcactggaac tcagctgact gtgctgggcg gaggaggctc cgaagtgcag      420

cttcaacaat caggaccagg actcgtcaaa ccatcacaga ccctctccct cacatgtgcc      480

atctccgggg actccatgtt gagcaattcc gacacttgga attggattag acaaagcccg      540

tcccggggtc tggaatggtt gggacgcacc taccaccggt ctacttggta cgacgactac      600

gcgtcatccg tgcggggaag agtgtccatc aacgtggaca cctccaagaa ccagtacagc      660

ctgcagctta atgccgtgac tcctgaggat acgggcgtct actactgcgc ccgcgtccgc      720

ctgcaagacg ggaacagctg gagcgatgca ttcgatgtct ggggccaggg aactatggtc      780

accgtgtcgt ctggaggggg agggagtgaa attgtgatga cccagtcacc cgccactctt      840

agcctttcac ccggtgagcg cgcaaccctg tcttgcagag cctcccaaga catctcaaaa      900

taccttaatt ggtatcaaca gaagcccgga caggctcctc gccttctgat ctaccacacc      960

agccggctcc attctggaat ccctgccagg ttcagcggta gcggatctgg gaccgactac     1020

accctcacta tcagctcact gcagccagag gacttcgctg tctatttctg tcagcaaggg     1080

aacaccctgc cctacacctt tggacagggc accaagctcg agattaaagg tggaggtggc     1140

agcggaggag gtgggtccgg cggtggagga agccaggtcc aactccaaga aagcggaccg     1200

ggtcttgtga agccatcaga aactctttca ctgacttgta ctgtgagcgg agtgtctctc     1260

cccgattacg gggtgtcttg gatcagacag ccaccgggga agggtctgga atggattgga     1320

gtgatttggg gctctgagac tacttactac caatcatccc tcaagtcacg cgtcaccatc     1380

tcaaaggaca actctaagaa tcaggtgtca ctgaaactgt catctgtgac cgcagccgac     1440

accgccgtgt actattgcgc taagcattac tattatggcg ggagctacgc aatggattac     1500

tggggacagg gtactctggt caccgtgtcc agcaccacta ccccagcacc gaggccaccc     1560

accccggctc ctaccatcgc ctcccagcct ctgtccctgc gtccggaggc atgtagaccc     1620

gcagctggtg gggccgtgca tacccggggt cttgacttcg cctgcgatat ctacatttgg     1680

gcccctctgg ctggtacttg cggggtcctg ctgctttcac tcgtgatcac tctttactgt     1740

aagcgcggtc ggaagaagct gctgtacatc tttaagcaac ccttcatgag gcctgtgcag     1800

actactcaag aggaggacgg ctgttcatgc cggttcccag aggaggagga aggcggctgc     1860

gaactgcgcg tgaaattcag ccgcagcgca gatgctccag cctaccagca ggggcagaac     1920

cagctctaca acgaactcaa tcttggtcgg agagaggagt acgacgtgct ggacaagcgg     1980

agaggacggg acccagaaat gggcgggaag ccgcgcagaa agaatcccca agagggcctg     2040

tacaacgagc tccaaaagga taagatggca gaagcctata gcgagattgg tatgaaaggg     2100

gaacgcagaa gaggcaaagg ccacgacgga ctgtaccagg gactcagcac cgccaccaag     2160

gacacctatg acgctcttca catgcaggcc ctgccgcctc gg                        2202


<210>  6
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser 
            20                  25                  30          


Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser 
        35                  40                  45              


Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu 
                85                  90                  95      


Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser 
            100                 105                 110         


Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln 
        115                 120                 125             


Leu Thr Val Leu Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser 
    130                 135                 140                 


Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala 
145                 150                 155                 160 


Ile Ser Gly Asp Ser Met Leu Ser Asn Ser Asp Thr Trp Asn Trp Ile 
                165                 170                 175     


Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr His 
            180                 185                 190         


Arg Ser Thr Trp Tyr Asp Asp Tyr Ala Ser Ser Val Arg Gly Arg Val 
        195                 200                 205             


Ser Ile Asn Val Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn 
    210                 215                 220                 


Ala Val Thr Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Val Arg 
225                 230                 235                 240 


Leu Gln Asp Gly Asn Ser Trp Ser Asp Ala Phe Asp Val Trp Gly Gln 
                245                 250                 255     


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Ile Val 
            260                 265                 270         


Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
        275                 280                 285             


Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    290                 295                 300                 


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr 
305                 310                 315                 320 


Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            340                 345                 350         


Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        355                 360                 365             


Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
385                 390                 395                 400 


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser 
                405                 410                 415     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            420                 425                 430         


Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr 
        435                 440                 445             


Tyr Tyr Gln Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn 
    450                 455                 460                 


Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                485                 490                 495     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
            500                 505                 510         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        515                 520                 525             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    530                 535                 540                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
545                 550                 555                 560 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                565                 570                 575     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            580                 585                 590         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        595                 600                 605             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    610                 615                 620                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
625                 630                 635                 640 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                645                 650                 655     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            660                 665                 670         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        675                 680                 685             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    690                 695                 700                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
705                 710                 715                 720 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730                 


<210>  7
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
atggccctgc ccgtgactgc gctcctgctt ccgttggccc tgctcctgca tgccgccaga       60

cctcagtccg ctctgactca gccggcctca gcttcggggt cccctggtca aagcgtcact      120

atttcctgta ccggaacctc atcagacgtg ggcggctaca attacgtgtc ctggtaccaa      180

cagcaccccg gaaaggctcc taagcttatg atctacgacg tgtccaaccg gccgtcagga      240

gtgtccaaca gattctccgg ctccaagagc ggaaacactg ccagcttgac cattagcggc      300

ttgcaggccg aggacgaagc cgactactac tgctctagct acacatcctc gtctaccctc      360

tacgtgtttg gaacggggac ccagctgact gtgctcgggg gtggaggatc agaggtgcaa      420

ctccagcagt ccggtcctgg cctcgtgaaa ccgtcccaaa ccctgtccct gacttgcgcc      480

atctcgggcg actccatgct gtccaattcc gacacctgga actggattag acaatcgcct      540

agccggggac tcgaatggct gggccggacc taccaccggt ccacgtggta tgacgactac      600

gcaagctccg tccggggaag ggtgtccatt aacgtcgata cctccaagaa ccagtacagc      660

cttcagctga acgctgtgac ccccgaggat accggcgtct actactgtgc aagagtgcga      720

ttgcaggatg gaaactcgtg gtcggacgca ttcgatgtct ggggacaggg aactatggtg      780

accgtgtcct cgggcggagg cgggagcgga ggaggaggct ctggcggagg aggaagcgag      840

attgtcatga ctcagtcccc ggccacactc tccctgtcac ccggagaaag agcaaccctg      900

agctgcaggg cgtcccagga catctcgaag tacctgaact ggtaccagca gaagcctgga      960

caagcacccc gcctcctgat ctaccacacc tcgcggctgc attcgggaat ccccgccaga     1020

ttctcaggga gcggatcagg aaccgactac accctgacta tctcgagcct gcaaccagag     1080

gatttcgccg tgtacttctg ccagcaagga aacaccctgc cctacacctt tggacaggga     1140

accaagctcg agattaaggg gggtggtgga tcgggagggg gtggatcagg aggaggcggc     1200

tcacaagtcc agctgcaaga atccggtccg ggacttgtga agccgtccga aaccctgtca     1260

ctgacttgca ctgtgtccgg ggtgtcattg cccgactacg gcgtgagctg gattcggcag     1320

ccccctggaa agggattgga atggatcggc gtgatctggg gttcggaaac tacctactat     1380

cagtcctcac tgaagtcccg cgtgaccatc agcaaggata attccaaaaa ccaagtgtct     1440

ctgaagctct ccagcgtcac tgccgccgat actgccgtgt actactgcgc caagcactac     1500

tattacggcg gttcgtacgc catggactac tggggccaag ggacactcgt gaccgtgtca     1560

tccaccacta ccccagcacc gaggccaccc accccggctc ctaccatcgc ctcccagcct     1620

ctgtccctgc gtccggaggc atgtagaccc gcagctggtg gggccgtgca tacccggggt     1680

cttgacttcg cctgcgatat ctacatttgg gcccctctgg ctggtacttg cggggtcctg     1740

ctgctttcac tcgtgatcac tctttactgt aagcgcggtc ggaagaagct gctgtacatc     1800

tttaagcaac ccttcatgag gcctgtgcag actactcaag aggaggacgg ctgttcatgc     1860

cggttcccag aggaggagga aggcggctgc gaactgcgcg tgaaattcag ccgcagcgca     1920

gatgctccag cctaccagca ggggcagaac cagctctaca acgaactcaa tcttggtcgg     1980

agagaggagt acgacgtgct ggacaagcgg agaggacggg acccagaaat gggcgggaag     2040

ccgcgcagaa agaatcccca agagggcctg tacaacgagc tccaaaagga taagatggca     2100

gaagcctata gcgagattgg tatgaaaggg gaacgcagaa gaggcaaagg ccacgacgga     2160

ctgtaccagg gactcagcac cgccaccaag gacacctatg acgctcttca catgcaggcc     2220

ctgccgcctc gg                                                         2232


<210>  8
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser 
            20                  25                  30          


Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser 
        35                  40                  45              


Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu 
                85                  90                  95      


Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser 
            100                 105                 110         


Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln 
        115                 120                 125             


Leu Thr Val Leu Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser 
    130                 135                 140                 


Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala 
145                 150                 155                 160 


Ile Ser Gly Asp Ser Met Leu Ser Asn Ser Asp Thr Trp Asn Trp Ile 
                165                 170                 175     


Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr His 
            180                 185                 190         


Arg Ser Thr Trp Tyr Asp Asp Tyr Ala Ser Ser Val Arg Gly Arg Val 
        195                 200                 205             


Ser Ile Asn Val Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn 
    210                 215                 220                 


Ala Val Thr Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Val Arg 
225                 230                 235                 240 


Leu Gln Asp Gly Asn Ser Trp Ser Asp Ala Phe Asp Val Trp Gly Gln 
                245                 250                 255     


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
        275                 280                 285             


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
    290                 295                 300                 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
305                 310                 315                 320 


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
                325                 330                 335     


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
            340                 345                 350         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
        355                 360                 365             


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
    370                 375                 380                 


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
                405                 410                 415     


Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
            420                 425                 430         


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        435                 440                 445             


Ile Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu 
    450                 455                 460                 


Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser 
465                 470                 475                 480 


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
            500                 505                 510         


Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
        515                 520                 525             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    530                 535                 540                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
545                 550                 555                 560 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                565                 570                 575     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            580                 585                 590         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        595                 600                 605             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    610                 615                 620                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
625                 630                 635                 640 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                645                 650                 655     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            660                 665                 670         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        675                 680                 685             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    690                 695                 700                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
705                 710                 715                 720 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                725                 730                 735     


His Met Gln Ala Leu Pro Pro Arg 
            740                 


<210>  9
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
atggccctgc ccgtgactgc gctcctgctt ccgttggccc tgctcctgca tgccgccaga       60

cctcagtccg ctctgactca gccggcctca gcttcggggt cccctggtca aagcgtcact      120

atttcctgta ccggaacctc atcagacgtg ggcggctaca attacgtgtc ctggtaccaa      180

cagcaccccg gaaaggctcc taagcttatg atctacgacg tgtccaaccg gccgtcagga      240

gtgtccaaca gattctccgg ctccaagagc ggaaacactg ccagcttgac cattagcggc      300

ttgcaggccg aggacgaagc cgactactac tgctctagct acacatcctc gtctaccctc      360

tacgtgtttg gaacggggac ccagctgact gtgctcgggg gtggaggatc agaggtgcaa      420

ctccagcagt ccggtcctgg cctcgtgaaa ccgtcccaaa ccctgtccct gacttgcgcc      480

atctcgggcg actccatgct gtccaattcc gacacctgga actggattag acaatcgcct      540

agccggggac tcgaatggct gggccggacc taccaccggt ccacgtggta tgacgactac      600

gcaagctccg tccggggaag ggtgtccatt aacgtcgata cctccaagaa ccagtacagc      660

cttcagctga acgctgtgac ccccgaggat accggcgtct actactgtgc aagagtgcga      720

ttgcaggatg gaaactcgtg gtcggacgca ttcgatgtct ggggacaggg aactatggtc      780

actgtgtcct ccggcggtgg aggctcgggg gggggcggct caggaggagg cggctcacaa      840

gtccagctgc aagaatccgg tccgggactt gtgaagccgt ccgaaaccct gtcactgact      900

tgcactgtgt ccggggtgtc attgcccgac tacggcgtga gctggattcg gcagccccct      960

ggaaagggat tggaatggat cggcgtgatc tggggttcgg aaactaccta ctatcagtcc     1020

tcactgaagt cccgcgtgac catcagcaag gataattcca aaaaccaagt gtctctgaag     1080

ctctccagcg tcactgccgc cgatactgcc gtgtactact gcgccaagca ctactattac     1140

ggcggttcgt acgccatgga ctactgggga caaggcactc ttgtgactgt gtcaagcggc     1200

ggtggaggga gcggtggggg cggttcagga ggaggcggat cagagatcgt gatgacccaa     1260

tccccagcca ccctgtccct cagccctgga gaaagagcca ccctgagctg ccgggcctcc     1320

caggatatca gcaagtactt gaactggtac caacaaaagc cggggcaggc gccccggctc     1380

ctgatctacc acacctcgcg cctccactca ggtatccccg ccagattctc agggagcggc     1440

tccggtactg actacaccct gactatttcc tcactgcagc cagaggactt tgccgtgtac     1500

ttctgccagc agggaaacac tctgccgtac accttcgggc agggaacgaa gcttgaaatt     1560

aagaccacta ccccagcacc gaggccaccc accccggctc ctaccatcgc ctcccagcct     1620

ctgtccctgc gtccggaggc atgtagaccc gcagctggtg gggccgtgca tacccggggt     1680

cttgacttcg cctgcgatat ctacatttgg gcccctctgg ctggtacttg cggggtcctg     1740

ctgctttcac tcgtgatcac tctttactgt aagcgcggtc ggaagaagct gctgtacatc     1800

tttaagcaac ccttcatgag gcctgtgcag actactcaag aggaggacgg ctgttcatgc     1860

cggttcccag aggaggagga aggcggctgc gaactgcgcg tgaaattcag ccgcagcgca     1920

gatgctccag cctaccagca ggggcagaac cagctctaca acgaactcaa tcttggtcgg     1980

agagaggagt acgacgtgct ggacaagcgg agaggacggg acccagaaat gggcgggaag     2040

ccgcgcagaa agaatcccca agagggcctg tacaacgagc tccaaaagga taagatggca     2100

gaagcctata gcgagattgg tatgaaaggg gaacgcagaa gaggcaaagg ccacgacgga     2160

ctgtaccagg gactcagcac cgccaccaag gacacctatg acgctcttca catgcaggcc     2220

ctgccgcctc gg                                                         2232


<210>  10
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser 
            20                  25                  30          


Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser 
        35                  40                  45              


Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu 
                85                  90                  95      


Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser 
            100                 105                 110         


Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln 
        115                 120                 125             


Leu Thr Val Leu Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser 
    130                 135                 140                 


Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala 
145                 150                 155                 160 


Ile Ser Gly Asp Ser Met Leu Ser Asn Ser Asp Thr Trp Asn Trp Ile 
                165                 170                 175     


Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr His 
            180                 185                 190         


Arg Ser Thr Trp Tyr Asp Asp Tyr Ala Ser Ser Val Arg Gly Arg Val 
        195                 200                 205             


Ser Ile Asn Val Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn 
    210                 215                 220                 


Ala Val Thr Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Val Arg 
225                 230                 235                 240 


Leu Gln Asp Gly Asn Ser Trp Ser Asp Ala Phe Asp Val Trp Gly Gln 
                245                 250                 255     


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
        275                 280                 285             


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser 
    290                 295                 300                 


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser Glu Thr Thr 
                325                 330                 335     


Tyr Tyr Gln Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn 
            340                 345                 350         


Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
    370                 375                 380                 


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
                405                 410                 415     


Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
            420                 425                 430         


Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His 
    450                 455                 460                 


Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
                485                 490                 495     


Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe 
            500                 505                 510         


Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
        515                 520                 525             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    530                 535                 540                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
545                 550                 555                 560 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                565                 570                 575     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            580                 585                 590         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        595                 600                 605             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    610                 615                 620                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
625                 630                 635                 640 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                645                 650                 655     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            660                 665                 670         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        675                 680                 685             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    690                 695                 700                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
705                 710                 715                 720 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                725                 730                 735     


His Met Gln Ala Leu Pro Pro Arg 
            740                 


<210>  11
<211>  2985
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgaagtgc agctgcagca gtcagggcct ggcctggtca agccgtcgca gaccctctcc      120

ctgacatgcg ccattagcgg ggactccatg ctgagcaact cggacacctg gaactggatt      180

cggcagtccc cttcccgggg actcgagtgg ctcggacgca cctaccatcg gagcacttgg      240

tacgacgact acgcctcctc cgtgagaggt cgcgtgtcga tcaacgtgga tacctcgaag      300

aaccagtata gcttgcaact gaacgccgtg acccctgagg ataccggagt gtactattgt      360

gcgagagtca ggctgcaaga cggaaactcc tggtccgacg catttgatgt ctggggacag      420

ggtactatgg tcacggtgtc atctggaggc ggaggatcgc aaagcgccct gactcagccg      480

gcttcggcta gcggttcacc ggggcagtcc gtgactatct cctgcaccgg gacttcctcc      540

gacgtgggag gctacaatta cgtgtcctgg taccagcaac accccggcaa agccccaaag      600

ctgatgatct acgacgtcag caacagaccc agcggagtgt ccaaccggtt cagcggctcc      660

aagtccggca acaccgcctc cctgaccatc agcgggcttc aggccgaaga tgaggcggat      720

tactactgct cctcgtacac ctcaagctca actctgtacg tgttcggcac cggtactcag      780

ctcaccgtgc tgaccactac cccagcaccg aggccaccca ccccggctcc taccatcgcc      840

tcccagcctc tgtccctgcg tccggaggca tgtagacccg cagctggtgg ggccgtgcat      900

acccggggtc ttgacttcgc ctgcgatatc tacatttggg cccctctggc tggtacttgc      960

ggggtcctgc tgctttcact cgtgatcact ctttactgta agcgcggtcg gaagaagctg     1020

ctgtacatct ttaagcaacc cttcatgagg cctgtgcaga ctactcaaga ggaggacggc     1080

tgttcatgcc ggttcccaga ggaggaggaa ggcggctgcg aactgcgcgt gaaattcagc     1140

cgcagcgcag atgctccagc ctaccagcag gggcagaacc agctctacaa cgaactcaat     1200

cttggtcgga gagaggagta cgacgtgctg gacaagcgga gaggacggga cccagaaatg     1260

ggcgggaagc cgcgcagaaa gaatccccaa gagggcctgt acaacgagct ccaaaaggat     1320

aagatggcag aagcctatag cgagattggt atgaaagggg aacgcagaag aggcaaaggc     1380

cacgacggac tgtaccaggg actcagcacc gccaccaagg acacctatga cgctcttcac     1440

atgcaggccc tgccgcctcg gggaagcgga gctactaact tcagcctgct gaagcaggct     1500

ggagacgtgg aggagaaccc tggacctatg gccttaccag tgaccgcctt gctcctgccg     1560

ctggccttgc tgctccacgc cgccaggccg gaaattgtga tgacccagtc acccgccact     1620

cttagccttt cacccggtga gcgcgcaacc ctgtcttgca gagcctccca agacatctca     1680

aaatacctta attggtatca acagaagccc ggacaggctc ctcgccttct gatctaccac     1740

accagccggc tccattctgg aatccctgcc aggttcagcg gtagcggatc tgggaccgac     1800

tacaccctca ctatcagctc actgcagcca gaggacttcg ctgtctattt ctgtcagcaa     1860

gggaacaccc tgccctacac ctttggacag ggcaccaagc tcgagattaa aggtggaggt     1920

ggcagcggag gaggtgggtc cggcggtgga ggaagccagg tccaactcca agaaagcgga     1980

ccgggtcttg tgaagccatc agaaactctt tcactgactt gtactgtgag cggagtgtct     2040

ctccccgatt acggggtgtc ttggatcaga cagccaccgg ggaagggtct ggaatggatt     2100

ggagtgattt ggggctctga gactacttac taccaatcat ccctcaagtc acgcgtcacc     2160

atctcaaagg acaactctaa gaatcaggtg tcactgaaac tgtcatctgt gaccgcagcc     2220

gacaccgccg tgtactattg cgctaagcat tactattatg gcgggagcta cgcaatggat     2280

tactggggac agggtactct ggtcaccgtg tccagcacca cgacgccagc gccgcgacca     2340

ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg     2400

ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc     2460

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac     2520

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta     2580

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     2640

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag     2700

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     2760

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     2820

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     2880

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     2940

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     2985


<210>  12
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Met Leu Ser Asn Ser Asp Thr Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr His Arg Ser Thr Trp 
65                  70                  75                  80  


Tyr Asp Asp Tyr Ala Ser Ser Val Arg Gly Arg Val Ser Ile Asn Val 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn Ala Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Val Arg Leu Gln Asp Gly 
        115                 120                 125             


Asn Ser Trp Ser Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
145                 150                 155                 160 


Ala Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr 
                165                 170                 175     


Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln 
            180                 185                 190         


Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn 
        195                 200                 205             


Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val Phe Gly 
                245                 250                 255     


Thr Gly Thr Gln Leu Thr Val Leu Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
    530                 535                 540                 


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser 
545                 550                 555                 560 


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
                565                 570                 575     


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe 
            580                 585                 590         


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
        595                 600                 605             


Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
    610                 615                 620                 


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
                645                 650                 655     


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
            660                 665                 670         


Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp 
        675                 680                 685             


Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp 
    690                 695                 700                 


Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser Arg Val Thr 
705                 710                 715                 720 


Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser 
                725                 730                 735     


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr 
            740                 745                 750         


Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        755                 760                 765             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    770                 775                 780                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
785                 790                 795                 800 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                805                 810                 815     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            820                 825                 830         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        835                 840                 845             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    850                 855                 860                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
865                 870                 875                 880 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                885                 890                 895     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            900                 905                 910         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        915                 920                 925             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    930                 935                 940                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
945                 950                 955                 960 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                965                 970                 975     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            980                 985                 990         


Pro Pro Arg 
        995 


<210>  13
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Met Leu Ser Asn Ser Asp Thr Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr His Arg Ser Thr Trp 
65                  70                  75                  80  


Tyr Asp Asp Tyr Ala Ser Ser Val Arg Gly Arg Val Ser Ile Asn Val 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn Ala Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Val Arg Leu Gln Asp Gly 
        115                 120                 125             


Asn Ser Trp Ser Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
145                 150                 155                 160 


Ala Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr 
                165                 170                 175     


Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln 
            180                 185                 190         


Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn 
        195                 200                 205             


Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val Phe Gly 
                245                 250                 255     


Thr Gly Thr Gln Leu Thr Val Leu Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505             


<210>  14
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15      


Leu His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
145                 150                 155                 160 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys 
        195                 200                 205             


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
    210                 215                 220                 


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  15
<211>  2985
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaaattg tgatgaccca gtcacccgcc actcttagcc tttcacccgg tgagcgcgca      120

accctgtctt gcagagcctc ccaagacatc tcaaaatacc ttaattggta tcaacagaag      180

cccggacagg ctcctcgcct tctgatctac cacaccagcc ggctccattc tggaatccct      240

gccaggttca gcggtagcgg atctgggacc gactacaccc tcactatcag ctcactgcag      300

ccagaggact tcgctgtcta tttctgtcag caagggaaca ccctgcccta cacctttgga      360

cagggcacca agctcgagat taaaggtgga ggtggcagcg gaggaggtgg gtccggcggt      420

ggaggaagcc aggtccaact ccaagaaagc ggaccgggtc ttgtgaagcc atcagaaact      480

ctttcactga cttgtactgt gagcggagtg tctctccccg attacggggt gtcttggatc      540

agacagccac cggggaaggg tctggaatgg attggagtga tttggggctc tgagactact      600

tactaccaat catccctcaa gtcacgcgtc accatctcaa aggacaactc taagaatcag      660

gtgtcactga aactgtcatc tgtgaccgca gccgacaccg ccgtgtacta ttgcgctaag      720

cattactatt atggcgggag ctacgcaatg gattactggg gacagggtac tctggtcacc      780

gtgtccagca ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg aagcggagct actaacttca gcctgctgaa gcaggctgga     1500

gacgtggagg agaaccctgg acctatggcc ctccctgtca ccgccctgct gcttccgctg     1560

gctcttctgc tccacgccgc tcggcccgaa gtgcagctgc agcagtcagg gcctggcctg     1620

gtcaagccgt cgcagaccct ctccctgaca tgcgccatta gcggggactc catgctgagc     1680

aactcggaca cctggaactg gattcggcag tccccttccc ggggactcga gtggctcgga     1740

cgcacctacc atcggagcac ttggtacgac gactacgcct cctccgtgag aggtcgcgtg     1800

tcgatcaacg tggatacctc gaagaaccag tatagcttgc aactgaacgc cgtgacccct     1860

gaggataccg gagtgtacta ttgtgcgaga gtcaggctgc aagacggaaa ctcctggtcc     1920

gacgcatttg atgtctgggg acagggtact atggtcacgg tgtcatctgg aggcggagga     1980

tcgcaaagcg ccctgactca gccggcttcg gctagcggtt caccggggca gtccgtgact     2040

atctcctgca ccgggacttc ctccgacgtg ggaggctaca attacgtgtc ctggtaccag     2100

caacaccccg gcaaagcccc aaagctgatg atctacgacg tcagcaacag acccagcgga     2160

gtgtccaacc ggttcagcgg ctccaagtcc ggcaacaccg cctccctgac catcagcggg     2220

cttcaggccg aagatgaggc ggattactac tgctcctcgt acacctcaag ctcaactctg     2280

tacgtgttcg gcaccggtac tcagctcacc gtgctgacca ctaccccagc accgaggcca     2340

cccaccccgg ctcctaccat cgcctcccag cctctgtccc tgcgtccgga ggcatgtaga     2400

cccgcagctg gtggggccgt gcatacccgg ggtcttgact tcgcctgcga tatctacatt     2460

tgggcccctc tggctggtac ttgcggggtc ctgctgcttt cactcgtgat cactctttac     2520

tgtaagcgcg gtcggaagaa gctgctgtac atctttaagc aacccttcat gaggcctgtg     2580

cagactactc aagaggagga cggctgttca tgccggttcc cagaggagga ggaaggcggc     2640

tgcgaactgc gcgtgaaatt cagccgcagc gcagatgctc cagcctacca gcaggggcag     2700

aaccagctct acaacgaact caatcttggt cggagagagg agtacgacgt gctggacaag     2760

cggagaggac gggacccaga aatgggcggg aagccgcgca gaaagaatcc ccaagagggc     2820

ctgtacaacg agctccaaaa ggataagatg gcagaagcct atagcgagat tggtatgaaa     2880

ggggaacgca gaagaggcaa aggccacgac ggactgtacc agggactcag caccgccacc     2940

aaggacacct atgacgctct tcacatgcag gccctgccgc ctcgg                     2985


<210>  16
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro 
            500                 505                 510         


Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg 
        515                 520                 525             


Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser 
    530                 535                 540                 


Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Met Leu Ser 
545                 550                 555                 560 


Asn Ser Asp Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu 
                565                 570                 575     


Glu Trp Leu Gly Arg Thr Tyr His Arg Ser Thr Trp Tyr Asp Asp Tyr 
            580                 585                 590         


Ala Ser Ser Val Arg Gly Arg Val Ser Ile Asn Val Asp Thr Ser Lys 
        595                 600                 605             


Asn Gln Tyr Ser Leu Gln Leu Asn Ala Val Thr Pro Glu Asp Thr Gly 
    610                 615                 620                 


Val Tyr Tyr Cys Ala Arg Val Arg Leu Gln Asp Gly Asn Ser Trp Ser 
625                 630                 635                 640 


Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser 
            660                 665                 670         


Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser 
        675                 680                 685             


Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly 
    690                 695                 700                 


Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly 
705                 710                 715                 720 


Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu 
                725                 730                 735     


Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser 
            740                 745                 750         


Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln 
        755                 760                 765             


Leu Thr Val Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    770                 775                 780                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
785                 790                 795                 800 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                805                 810                 815     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            820                 825                 830         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        835                 840                 845             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    850                 855                 860                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
865                 870                 875                 880 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                885                 890                 895     


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            900                 905                 910         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        915                 920                 925             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    930                 935                 940                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
945                 950                 955                 960 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                965                 970                 975     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            980                 985                 990         


Pro Pro Arg 
        995 


<210>  17
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505         


<210>  18
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15      


Leu His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly 
        35                  40                  45              


Asp Ser Met Leu Ser Asn Ser Asp Thr Trp Asn Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr His Arg Ser Thr 
65                  70                  75                  80  


Trp Tyr Asp Asp Tyr Ala Ser Ser Val Arg Gly Arg Val Ser Ile Asn 
                85                  90                  95      


Val Asp Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn Ala Val Thr 
            100                 105                 110         


Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Val Arg Leu Gln Asp 
        115                 120                 125             


Gly Asn Ser Trp Ser Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln 
145                 150                 155                 160 


Pro Ala Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys 
                165                 170                 175     


Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr 
            180                 185                 190         


Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser 
        195                 200                 205             


Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly 
    210                 215                 220                 


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
225                 230                 235                 240 


Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val Phe 
                245                 250                 255     


Gly Thr Gly Thr Gln Leu Thr Val Leu Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  19
<211>  2985
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
atggcacttc ccgtcaccgc cctgctgctc ccactcgccc tccttctgca cgccgcccgc       60

cccgaagtgc agctgcagca gtcaggaccg ggcctggtca aaccttcgca gactctgtcc      120

ctgacttgcg ctataagcgg ggactccatg ctgagcaatt cggacacttg gaactggatt      180

cgccaaagcc ccagccgggg tctggaatgg ctgggaagga cctaccatcg ctctacttgg      240

tacgacgact acgccagctc cgtgcgagga cgcgtgtcca tcaacgtgga cacctccaag      300

aaccagtact cgcttcaact caacgcagtg acccctgaag ataccggagt ctactattgc      360

gcccgcgtgc ggctccagga cgggaactcc tggtcggacg ctttcgatgt ctggggacag      420

ggcactatgg tcaccgtcag ctccggcggc ggcggtagcc aatcggcgct gacacagccg      480

gcttccgcct cgggatcgcc tggacagtcg gtgaccatct cgtgcactgg aacctcctcc      540

gacgtgggcg gctacaatta tgtgtcatgg taccagcagc acccgggaaa ggcccctaag      600

ctgatgatct acgacgtgtc caatagacct agcggggtgt caaacagatt ctccggatcc      660

aaatccggaa acactgcctc cctgaccatt tccggactgc aggccgagga cgaagccgat      720

tactactgct cctcttacac ctcctcatcc accctctacg tgtttgggac tgggacccag      780

ctgaccgtcc tcactaccac cccggccccg cggcccccta caccggcacc gactattgcc      840

agccagcctc tctcgctgcg gccggaggcc tgccgcccag ccgccggcgg agccgtgcac      900

acccgcggtc tggacttcgc gtgcgatatc tacatctggg ctccgctggc cgggacttgt      960

ggcgtgctgc tgctgtctct ggtcatcaca ctgtactgca agcgcggaag aaagaagctg     1020

ctctacatct tcaagcaacc cttcatgcgg cctgtgcaga ccacccagga agaggatggc     1080

tgctcctgcc ggttcccgga ggaagaagag ggcggatgcg aactgcgcgt gaagttcagc     1140

cgaagcgccg acgccccggc ctaccagcag ggccagaacc aactgtacaa cgaactcaac     1200

ctgggtcgga gagaagagta cgacgtgctg gacaaaagac gcggcaggga ccccgagatg     1260

ggcggaaagc ctcgccgcaa gaacccgcag gagggcctct acaacgagct gcagaaggac     1320

aagatggccg aagcctactc agagatcggc atgaaggggg agcggaggcg cgggaagggc     1380

cacgacggtt tgtaccaagg actttccact gcgaccaagg acacctacga tgccctccat     1440

atgcaagccc tgccgccccg gggttccgga gctaccaact tctcgctgtt gaagcaggcc     1500

ggagatgtcg aggaaaaccc gggacctatg gccctgccag tgaccgcgct cctgctgccc     1560

ctggctctgc tgcttcacgc ggcccggcct gagattgtga tgactcagag cccggcgacc     1620

ctgtccctgt cccccgggga gagagcaacc ctgtcgtgcc gggcctccca agacatctca     1680

aagtacctca attggtatca gcagaagcca ggacaggctc cacggttgct gatctaccac     1740

acttcgagac tgcactcagg aatccccgcg cggttttccg gttccggctc cgggaccgac     1800

tacaccctga ccatcagctc gctccagcct gaggatttcg cagtgtactt ctgtcagcaa     1860

ggaaacaccc ttccatacac cttcggacag ggtaccaagc tggaaatcaa gggaggagga     1920

ggatctgggg gcggtggttc cggaggcggt ggaagccaag tgcagctcca ggaaagcgga     1980

cccgggctgg tcaagccgag cgaaaccctc tcactgactt gtactgtgtc cggagtgtcc     2040

ctgcctgact atggagtgtc ctggatccga cagccccccg gaaagggtct ggagtggatt     2100

ggggtcatct ggggctccga aactacctac taccagagca gcctcaagag ccgggtcacc     2160

atttcaaagg ataactccaa gaatcaagtg tccctgaagc tgtcctcagt gacagccgca     2220

gacaccgccg tgtactactg cgccaagcac tactactacg gaggctccta cgcaatggac     2280

tactggggac aaggcacttt ggtcactgtg tcaagcacca ccacccctgc gcctcggcct     2340

cctaccccgg ctcccactat cgcgagccag ccgctgagcc tgcggcctga ggcttgccga     2400

ccggccgctg gcggcgccgt gcatactcgg ggcctcgact ttgcctgtga catctacatc     2460

tgggcccccc tggccggaac gtgcggagtg ctgctgctgt cgctggtcat taccctgtat     2520

tgcaaacgcg gaaggaagaa gctgttgtac attttcaagc agcccttcat gcgcccggtg     2580

caaactactc aggaggaaga tggctgttcc tgtcggttcc ccgaagagga agaaggcggc     2640

tgcgagttga gggtcaagtt ctcccggtcc gccgatgctc ccgcctacca acaggggcag     2700

aaccagcttt ataacgaact gaacctgggc aggagggagg aatatgatgt gttggataag     2760

cgccggggcc gggacccaga aatgggggga aagcccagaa gaaagaaccc tcaagaggga     2820

ctttacaacg aattgcagaa agacaaaatg gccgaggcct actccgagat tgggatgaag     2880

ggcgaaagac ggagaggaaa ggggcacgac gggctctacc agggactcag caccgccacc     2940

aaagatacct acgacgccct gcatatgcag gcgctgccgc cgcgc                     2985


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Ser Asn Ser Asp Thr Trp Asn 
1               5           


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Arg Thr Tyr His Arg Ser Thr Trp Tyr Asp Asp Tyr Ala Ser Ser Val 
1               5                   10                  15      


Arg Gly 
        


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Val Arg Leu Gln Asp Gly Asn Ser Trp Ser Asp Ala Phe Asp Val 
1               5                   10                  15  


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Gly Asp Ser Met Leu Ser Asn Ser Asp 
1               5                   


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Tyr His Arg Ser Thr Trp Tyr 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Gly Asp Ser Met Leu Ser Asn Ser Asp Thr 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Thr Tyr His Arg Ser Thr Trp Tyr Asp 
1               5                   


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Ala Arg Val Arg Leu Gln Asp Gly Asn Ser Trp Ser Asp Ala Phe Asp 
1               5                   10                  15      


Val 
    


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Ser Ser Tyr Thr Ser Ser Ser Thr Leu Tyr Val 
1               5                   10      


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   10  


<210>  32
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Asp Val Ser 
1           


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Tyr Thr Ser Ser Ser Thr Leu Tyr 
1               5               


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
1               5                   10  


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser 
1               5                   10                  15      


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
1               5                   10                  15      


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Ser 
1               5                   10                  15      


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

His Thr Ser Arg Leu His Ser 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  43
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
gaaattgtga tgacccagtc acccgccact cttagccttt cacccggtga gcgcgcaacc       60

ctgtcttgca gagcctccca agacatctca aaatacctta attggtatca acagaagccc      120

ggacaggctc ctcgccttct gatctaccac accagccggc tccattctgg aatccctgcc      180

aggttcagcg gtagcggatc tgggaccgac tacaccctca ctatcagctc actgcagcca      240

gaggacttcg ctgtctattt ctgtcagcaa gggaacaccc tgccctacac ctttggacag      300

ggcaccaagc tcgagattaa aggtggaggt ggcagcggag gaggtgggtc cggcggtgga      360

ggaagccagg tccaactcca agaaagcgga ccgggtcttg tgaagccatc agaaactctt      420

tcactgactt gtactgtgag cggagtgtct ctccccgatt acggggtgtc ttggatcaga      480

cagccaccgg ggaagggtct ggaatggatt ggagtgattt ggggctctga gactacttac      540

taccaatcat ccctcaagtc acgcgtcacc atctcaaagg acaactctaa gaatcaggtg      600

tcactgaaac tgtcatctgt gaccgcagcc gacaccgccg tgtactattg cgctaagcat      660

tactattatg gcgggagcta cgcaatggat tactggggac agggtactct ggtcaccgtg      720

tccagc                                                                 726


<210>  44
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  45
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
gagattgtca tgactcagtc cccggccaca ctctccctgt cacccggaga aagagcaacc       60

ctgagctgca gggcgtccca ggacatctcg aagtacctga actggtacca gcagaagcct      120

ggacaagcac cccgcctcct gatctaccac acctcgcggc tgcattcggg aatccccgcc      180

agattctcag ggagcggatc aggaaccgac tacaccctga ctatctcgag cctgcaacca      240

gaggatttcg ccgtgtactt ctgccagcaa ggaaacaccc tgccctacac ctttggacag      300

ggaaccaagc tcgagattaa ggggggtggt ggatcgggag ggggtggatc aggaggaggc      360

ggctcacaag tccagctgca agaatccggt ccgggacttg tgaagccgtc cgaaaccctg      420

tcactgactt gcactgtgtc cggggtgtca ttgcccgact acggcgtgag ctggattcgg      480

cagccccctg gaaagggatt ggaatggatc ggcgtgatct ggggttcgga aactacctac      540

tatcagtcct cactgaagtc ccgcgtgacc atcagcaagg ataattccaa aaaccaagtg      600

tctctgaagc tctccagcgt cactgccgcc gatactgccg tgtactactg cgccaagcac      660

tactattacg gcggttcgta cgccatggac tactggggcc aagggacact cgtgaccgtg      720

tcatcc                                                                 726


<210>  46
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
caagtccagc tgcaagaatc cggtccggga cttgtgaagc cgtccgaaac cctgtcactg       60

acttgcactg tgtccggggt gtcattgccc gactacggcg tgagctggat tcggcagccc      120

cctggaaagg gattggaatg gatcggcgtg atctggggtt cggaaactac ctactatcag      180

tcctcactga agtcccgcgt gaccatcagc aaggataatt ccaaaaacca agtgtctctg      240

aagctctcca gcgtcactgc cgccgatact gccgtgtact actgcgccaa gcactactat      300

tacggcggtt cgtacgccat ggactactgg ggacaaggca ctcttgtgac tgtgtcaagc      360

ggcggtggag ggagcggtgg gggcggttca ggaggaggcg gatcagagat cgtgatgacc      420

caatccccag ccaccctgtc cctcagccct ggagaaagag ccaccctgag ctgccgggcc      480

tcccaggata tcagcaagta cttgaactgg taccaacaaa agccggggca ggcgccccgg      540

ctcctgatct accacacctc gcgcctccac tcaggtatcc ccgccagatt ctcagggagc      600

ggctccggta ctgactacac cctgactatt tcctcactgc agccagagga ctttgccgtg      660

tacttctgcc agcagggaaa cactctgccg tacaccttcg ggcagggaac gaagcttgaa      720

attaag                                                                 726


<210>  47
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  48
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
gagattgtga tgactcagag cccggcgacc ctgtccctgt cccccgggga gagagcaacc       60

ctgtcgtgcc gggcctccca agacatctca aagtacctca attggtatca gcagaagcca      120

ggacaggctc cacggttgct gatctaccac acttcgagac tgcactcagg aatccccgcg      180

cggttttccg gttccggctc cgggaccgac tacaccctga ccatcagctc gctccagcct      240

gaggatttcg cagtgtactt ctgtcagcaa ggaaacaccc ttccatacac cttcggacag      300

ggtaccaagc tggaaatcaa gggaggagga ggatctgggg gcggtggttc cggaggcggt      360

ggaagccaag tgcagctcca ggaaagcgga cccgggctgg tcaagccgag cgaaaccctc      420

tcactgactt gtactgtgtc cggagtgtcc ctgcctgact atggagtgtc ctggatccga      480

cagccccccg gaaagggtct ggagtggatt ggggtcatct ggggctccga aactacctac      540

taccagagca gcctcaagag ccgggtcacc atttcaaagg ataactccaa gaatcaagtg      600

tccctgaagc tgtcctcagt gacagccgca gacaccgccg tgtactactg cgccaagcac      660

tactactacg gaggctccta cgcaatggac tactggggac aaggcacttt ggtcactgtg      720

tcaagc                                                                 726


<210>  49
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
gaagtgcagc tgcagcagtc agggcctggc ctggtcaagc cgtcgcagac cctctccctg       60

acatgcgcca ttagcgggga ctccatgctg agcaactcgg acacctggaa ctggattcgg      120

cagtcccctt cccggggact cgagtggctc ggacgcacct accatcggag cacttggtac      180

gacgactacg cctcctccgt gagaggtcgc gtgtcgatca acgtggatac ctcgaagaac      240

cagtatagct tgcaactgaa cgccgtgacc cctgaggata ccggagtgta ctattgtgcg      300

agagtcaggc tgcaagacgg aaactcctgg tccgacgcat ttgatgtctg gggacagggt      360

actatggtca cggtgtcatc tggaggcgga ggatcgcaaa gcgccctgac tcagccggct      420

tcggctagcg gttcaccggg gcagtccgtg actatctcct gcaccgggac ttcctccgac      480

gtgggaggct acaattacgt gtcctggtac cagcaacacc ccggcaaagc cccaaagctg      540

atgatctacg acgtcagcaa cagacccagc ggagtgtcca accggttcag cggctccaag      600

tccggcaaca ccgcctccct gaccatcagc gggcttcagg ccgaagatga ggcggattac      660

tactgctcct cgtacacctc aagctcaact ctgtacgtgt tcggcaccgg tactcagctc      720

accgtgctg                                                              729


<210>  50
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Met Leu Ser Asn 
            20                  25                  30          


Ser Asp Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr His Arg Ser Thr Trp Tyr Asp Asp Tyr Ala 
    50                  55                  60                  


Ser Ser Val Arg Gly Arg Val Ser Ile Asn Val Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Tyr Ser Leu Gln Leu Asn Ala Val Thr Pro Glu Asp Thr Gly Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Val Arg Leu Gln Asp Gly Asn Ser Trp Ser Asp 
            100                 105                 110         


Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser Gly 
    130                 135                 140                 


Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
145                 150                 155                 160 


Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val 
            180                 185                 190         


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
    210                 215                 220                 


Tyr Thr Ser Ser Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln Leu 
225                 230                 235                 240 


Thr Val Leu 
            


<210>  51
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
gaagtgcagc tgcagcagtc aggaccgggc ctggtcaaac cttcgcagac tctgtccctg       60

acttgcgcta taagcgggga ctccatgctg agcaattcgg acacttggaa ctggattcgc      120

caaagcccca gccggggtct ggaatggctg ggaaggacct accatcgctc tacttggtac      180

gacgactacg ccagctccgt gcgaggacgc gtgtccatca acgtggacac ctccaagaac      240

cagtactcgc ttcaactcaa cgcagtgacc cctgaagata ccggagtcta ctattgcgcc      300

cgcgtgcggc tccaggacgg gaactcctgg tcggacgctt tcgatgtctg gggacagggc      360

actatggtca ccgtcagctc cggcggcggc ggtagccaat cggcgctgac acagccggct      420

tccgcctcgg gatcgcctgg acagtcggtg accatctcgt gcactggaac ctcctccgac      480

gtgggcggct acaattatgt gtcatggtac cagcagcacc cgggaaaggc ccctaagctg      540

atgatctacg acgtgtccaa tagacctagc ggggtgtcaa acagattctc cggatccaaa      600

tccggaaaca ctgcctccct gaccatttcc ggactgcagg ccgaggacga agccgattac      660

tactgctcct cttacacctc ctcatccacc ctctacgtgt ttgggactgg gacccagctg      720

accgtcctc                                                              729


<210>  52
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
gaagtgcagc ttcaacaatc aggaccagga ctcgtcaaac catcacagac cctctccctc       60

acatgtgcca tctccgggga ctccatgttg agcaattccg acacttggaa ttggattaga      120

caaagcccgt cccggggtct ggaatggttg ggacgcacct accaccggtc tacttggtac      180

gacgactacg cgtcatccgt gcggggaaga gtgtccatca acgtggacac ctccaagaac      240

cagtacagcc tgcagcttaa tgccgtgact cctgaggata cgggcgtcta ctactgcgcc      300

cgcgtccgcc tgcaagacgg gaacagctgg agcgatgcat tcgatgtctg gggccaggga      360

actatggtca ccgtgtcgtc tgggggcggt ggatcgggtg gcgggggttc ggggggcggc      420

ggctctcagt ccgctcttac ccaaccggcc tcagcctcgg ggagccccgg ccagagcgtg      480

accatttcct gcaccggcac ttcatccgac gtgggcggct acaactacgt gtcctggtac      540

caacagcacc cgggaaaggc ccccaagctc atgatctacg acgtgtccaa caggccctcg      600

ggagtgtcca accggttctc gggttcgaaa tcgggaaaca cagccagcct gaccatcagc      660

ggactgcagg ctgaagatga agccgactac tactgctcct cctacacctc gtcatccacg      720

ctctacgtgt tcggcactgg aactcagctg actgtgctg                             759


<210>  53
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Met Leu Ser Asn 
            20                  25                  30          


Ser Asp Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr His Arg Ser Thr Trp Tyr Asp Asp Tyr Ala 
    50                  55                  60                  


Ser Ser Val Arg Gly Arg Val Ser Ile Asn Val Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Tyr Ser Leu Gln Leu Asn Ala Val Thr Pro Glu Asp Thr Gly Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Val Arg Leu Gln Asp Gly Asn Ser Trp Ser Asp 
            100                 105                 110         


Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser 
    130                 135                 140                 


Ala Leu Thr Gln Pro Ala Ser Ala Ser Gly Ser Pro Gly Gln Ser Val 
145                 150                 155                 160 


Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
                165                 170                 175     


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
            180                 185                 190         


Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly 
        195                 200                 205             


Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr 
225                 230                 235                 240 


Leu Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
                245                 250             


<210>  54
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
cagtccgctc ttacccaacc ggcctcagcc tcggggagcc ccggccagag cgtgaccatt       60

tcctgcaccg gcacttcatc cgacgtgggc ggctacaact acgtgtcctg gtaccaacag      120

cacccgggaa aggcccccaa gctcatgatc tacgacgtgt ccaacaggcc ctcgggagtg      180

tccaaccggt tctcgggttc gaaatcggga aacacagcca gcctgaccat cagcggactg      240

caggctgaag atgaagccga ctactactgc tcctcctaca cctcgtcatc cacgctctac      300

gtgttcggca ctggaactca gctgactgtg ctgggcggag gaggctccga agtgcagctt      360

caacaatcag gaccaggact cgtcaaacca tcacagaccc tctccctcac atgtgccatc      420

tccggggact ccatgttgag caattccgac acttggaatt ggattagaca aagcccgtcc      480

cggggtctgg aatggttggg acgcacctac caccggtcta cttggtacga cgactacgcg      540

tcatccgtgc ggggaagagt gtccatcaac gtggacacct ccaagaacca gtacagcctg      600

cagcttaatg ccgtgactcc tgaggatacg ggcgtctact actgcgcccg cgtccgcctg      660

caagacggga acagctggag cgatgcattc gatgtctggg gccagggaac tatggtcacc      720

gtgtcgtct                                                              729


<210>  55
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 
        115                 120                 125             


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser 
    130                 135                 140                 


Met Leu Ser Asn Ser Asp Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser 
145                 150                 155                 160 


Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr His Arg Ser Thr Trp Tyr 
                165                 170                 175     


Asp Asp Tyr Ala Ser Ser Val Arg Gly Arg Val Ser Ile Asn Val Asp 
            180                 185                 190         


Thr Ser Lys Asn Gln Tyr Ser Leu Gln Leu Asn Ala Val Thr Pro Glu 
        195                 200                 205             


Asp Thr Gly Val Tyr Tyr Cys Ala Arg Val Arg Leu Gln Asp Gly Asn 
    210                 215                 220                 


Ser Trp Ser Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  56
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
cagtccgctc tgactcagcc ggcctcagct tcggggtccc ctggtcaaag cgtcactatt       60

tcctgtaccg gaacctcatc agacgtgggc ggctacaatt acgtgtcctg gtaccaacag      120

caccccggaa aggctcctaa gcttatgatc tacgacgtgt ccaaccggcc gtcaggagtg      180

tccaacagat tctccggctc caagagcgga aacactgcca gcttgaccat tagcggcttg      240

caggccgagg acgaagccga ctactactgc tctagctaca catcctcgtc taccctctac      300

gtgtttggaa cggggaccca gctgactgtg ctcgggggtg gaggatcaga ggtgcaactc      360

cagcagtccg gtcctggcct cgtgaaaccg tcccaaaccc tgtccctgac ttgcgccatc      420

tcgggcgact ccatgctgtc caattccgac acctggaact ggattagaca atcgcctagc      480

cggggactcg aatggctggg ccggacctac caccggtcca cgtggtatga cgactacgca      540

agctccgtcc ggggaagggt gtccattaac gtcgatacct ccaagaacca gtacagcctt      600

cagctgaacg ctgtgacccc cgaggatacc ggcgtctact actgtgcaag agtgcgattg      660

caggatggaa actcgtggtc ggacgcattc gatgtctggg gacagggaac tatggtgacc      720

gtgtcctcg                                                              729


<210>  57
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
cagtccgctc tgactcagcc ggcctcagct tcggggtccc ctggtcaaag cgtcactatt       60

tcctgtaccg gaacctcatc agacgtgggc ggctacaatt acgtgtcctg gtaccaacag      120

caccccggaa aggctcctaa gcttatgatc tacgacgtgt ccaaccggcc gtcaggagtg      180

tccaacagat tctccggctc caagagcgga aacactgcca gcttgaccat tagcggcttg      240

caggccgagg acgaagccga ctactactgc tctagctaca catcctcgtc taccctctac      300

gtgtttggaa cggggaccca gctgactgtg ctcgggggtg gaggatcaga ggtgcaactc      360

cagcagtccg gtcctggcct cgtgaaaccg tcccaaaccc tgtccctgac ttgcgccatc      420

tcgggcgact ccatgctgtc caattccgac acctggaact ggattagaca atcgcctagc      480

cggggactcg aatggctggg ccggacctac caccggtcca cgtggtatga cgactacgca      540

agctccgtcc ggggaagggt gtccattaac gtcgatacct ccaagaacca gtacagcctt      600

cagctgaacg ctgtgacccc cgaggatacc ggcgtctact actgtgcaag agtgcgattg      660

caggatggaa actcgtggtc ggacgcattc gatgtctggg gacagggaac tatggtcact      720

gtgtcctcc                                                              729


<210>  58
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccc                                                                     63


<210>  59
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  60
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
atggccctgc ccgtgactgc gctcctgctt ccgttggccc tgctcctgca tgccgccaga       60

cct                                                                     63


<210>  61
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  62
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
atggcacttc ccgtcaccgc cctgctgctc ccactcgccc tccttctgca cgccgcccgc       60

ccc                                                                     63


<210>  63
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
atggccctgc cagtgaccgc gctcctgctg cccctggctc tgctgcttca cgcggcccgg       60

cct                                                                     63


<210>  64
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
accactaccc cagcaccgag gccacccacc ccggctccta ccatcgcctc ccagcctctg       60

tccctgcgtc cggaggcatg tagacccgca gctggtgggg ccgtgcatac ccggggtctt      120

gacttcgcct gcgatatcta catttgggcc cctctggctg gtacttgcgg ggtcctgctg      180

ctttcactcg tgatcactct ttactgt                                          207


<210>  65
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  66
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
actaccaccc cggccccgcg gccccctaca ccggcaccga ctattgccag ccagcctctc       60

tcgctgcggc cggaggcctg ccgcccagcc gccggcggag ccgtgcacac ccgcggtctg      120

gacttcgcgt gcgatatcta catctgggct ccgctggccg ggacttgtgg cgtgctgctg      180

ctgtctctgg tcatcacact gtactgc                                          207


<210>  67
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgc                                          207


<210>  68
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
accaccaccc ctgcgcctcg gcctcctacc ccggctccca ctatcgcgag ccagccgctg       60

agcctgcggc ctgaggcttg ccgaccggcc gctggcggcg ccgtgcatac tcggggcctc      120

gactttgcct gtgacatcta catctgggcc cccctggccg gaacgtgcgg agtgctgctg      180

ctgtcgctgg tcattaccct gtattgc                                          207


<210>  69
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
aagcgcggtc ggaagaagct gctgtacatc tttaagcaac ccttcatgag gcctgtgcag       60

actactcaag aggaggacgg ctgttcatgc cggttcccag aggaggagga aggcggctgc      120

gaactg                                                                 126


<210>  70
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  71
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  72
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  72
aagcgcggaa gaaagaagct gctctacatc ttcaagcaac ccttcatgcg gcctgtgcag       60

accacccagg aagaggatgg ctgctcctgc cggttcccgg aggaagaaga gggcggatgc      120

gaactg                                                                 126


<210>  73
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  73
aaacgcggaa ggaagaagct gttgtacatt ttcaagcagc ccttcatgcg cccggtgcaa       60

actactcagg aggaagatgg ctgttcctgt cggttccccg aagaggaaga aggcggctgc      120

gagttg                                                                 126


<210>  74
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  74
cgcgtgaaat tcagccgcag cgcagatgct ccagcctacc agcaggggca gaaccagctc       60

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga      120

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac      180

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc      240

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc      300

tatgacgctc ttcacatgca ggccctgccg cctcgg                                336


<210>  75
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  76
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  76
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  77
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  77
cgcgtgaagt tcagccgaag cgccgacgcc ccggcctacc agcagggcca gaaccaactg       60

tacaacgaac tcaacctggg tcggagagaa gagtacgacg tgctggacaa aagacgcggc      120

agggaccccg agatgggcgg aaagcctcgc cgcaagaacc cgcaggaggg cctctacaac      180

gagctgcaga aggacaagat ggccgaagcc tactcagaga tcggcatgaa gggggagcgg      240

aggcgcggga agggccacga cggtttgtac caaggacttt ccactgcgac caaggacacc      300

tacgatgccc tccatatgca agccctgccg ccccgg                                336


<210>  78
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  78
agggtcaagt tctcccggtc cgccgatgct cccgcctacc aacaggggca gaaccagctt       60

tataacgaac tgaacctggg caggagggag gaatatgatg tgttggataa gcgccggggc      120

cgggacccag aaatgggggg aaagcccaga agaaagaacc ctcaagaggg actttacaac      180

gaattgcaga aagacaaaat ggccgaggcc tactccgaga ttgggatgaa gggcgaaaga      240

cggagaggaa aggggcacga cgggctctac cagggactca gcaccgccac caaagatacc      300

tacgacgccc tgcatatgca ggcgctgccg ccgcgc                                336


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  79
ttggcagaag ccgccgcgaa a                                                 21


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  80

Leu Ala Glu Ala Ala Ala Lys 
1               5           


<210>  81
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  81
ggtggaggtg gcagcggagg aggtgggtcc ggcggtggag gaagc                       45


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  82

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  83
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  83
ggcggaggcg ggagcggagg aggaggctct ggcggaggag gaagc                       45


<210>  84
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  84
ggcggtggag gctcgggggg gggcggctca ggaggaggcg gctca                       45


<210>  85
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  85
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  86
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  86

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  87
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  87
ggttccggag ctaccaactt ctcgctgttg aagcaggccg gagatgtcga ggaaaacccg       60

ggacct                                                                  66


<210>  88
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  88
ggtggaggtg gcagc                                                        15


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  89

Gly Gly Gly Gly Ser 
1               5   


<210>  90
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  90

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  91
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  91

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser His His His His His His His His 
            260                 265                 270     


<210>  92
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  92

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  93
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  93

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  94
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  95
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  95

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  96
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  96

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  97
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  98
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  99
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  100
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  101
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  102
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  102

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  103
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
        275                 280                 285             


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    290                 295                 300                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  104
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  104

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  105
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  105

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly 
        275                 280                 285             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    290                 295                 300                 


Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
305                 310                 315                 320 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                325                 330                 335     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
385                 390                 395                 400 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                405                 410                 415     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            420                 425                 430         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        435                 440                 445             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460     


<210>  106
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  106

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  107
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  107

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  108
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  108

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  109
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  109

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
        115                 120                 125             


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
    130                 135                 140                 


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
145                 150                 155                 160 


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
                165                 170                 175     


Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
            180                 185                 190         


Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro 
        195                 200                 205             


Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala 
    210                 215                 220                 


Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys 
225                 230                 235                 240 


Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His 
                245                 250                 255     


Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser 
            260                 265                 270         


Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
        275                 280                 


