                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Doudna, Jennifer A.
       Knott, Gavin
       Afsar Minhas, Fayyaz-ul-Amir
       Eitzinger, Simon
       Watters, Kyle E.
 
<120>  MODULATORS OF CAS9 POLYPEPTIDE ACTIVITY AND METHODS OF USE 
       THEREOF

<130>  BERK-421WO

<150>  US 62/941,332
<151>  2019-11-27

<160>  136   

<170>  PatentIn version 3.5

<210>  1
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Met Lys Asn Tyr Glu Val Thr Asn Glu Val Lys Asn Leu Asn Thr Gln 
1               5                   10                  15      


Val Glu Thr Ile Gly Gln Ala Val Asp Leu Tyr Lys Glu Tyr Gly Ser 
            20                  25                  30          


Asn Thr Ile Val Trp Ser Ile Asp Lys Asn Glu Asp Leu Ile Asp Glu 
        35                  40                  45              


Val Thr Glu Leu Val Ala Glu Tyr Ala Glu Lys Gly Thr Val Ile Lys 
    50                  55                  60                  


<210>  2
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Met Gly Lys Thr Tyr Trp Tyr Asn Glu Gly Thr Asp Thr Leu Leu Thr 
1               5                   10                  15      


Glu Lys Glu Tyr Lys Glu Leu Met Glu Arg Glu Ala Lys Ala Leu Tyr 
            20                  25                  30          


Glu Glu Val Gln Glu Glu Glu Lys Asp Phe Glu Ser Ser Glu Lys Thr 
        35                  40                  45              


Ser Phe Glu Glu Phe Leu Lys Thr Cys Tyr Glu Asn Glu Ser Asp Phe 
    50                  55                  60                  


Val Leu Ser Asp Asn Glu Gly Asn Lys Leu Glu Glu Trp 
65                  70                  75          


<210>  3
<211>  83
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Met Ser Lys Thr Met Tyr Lys Asn Asp Val Ile Glu Leu Ile Lys Asn 
1               5                   10                  15      


Ala Lys Thr Asn Asn Glu Glu Leu Leu Phe Thr Ser Val Glu Arg Asn 
            20                  25                  30          


Thr Arg Glu Ala Ala Thr Gln Tyr Phe Arg Cys Pro Glu Lys His Val 
        35                  40                  45              


Ser Asp Ala Gly Val Tyr Tyr Gly Glu Asp Phe Glu Phe Asp Gly Phe 
    50                  55                  60                  


Glu Ile Phe Glu Asp Asp Leu Ile Tyr Thr Arg Ser Tyr Asp Lys Glu 
65                  70                  75                  80  


Glu Leu Asn 
            


<210>  4
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Met Leu Arg Arg Val Asn His Val Lys Asn Val Leu Ala His Gly Glu 
1               5                   10                  15      


Phe Ala Glu Trp Ile Glu Asn Lys Ile Gly Ile His Tyr Arg Glu Ala 
            20                  25                  30          


Asn Arg Met Met Thr Val Ala Lys Gln Ile Pro Asn Val Ser Thr Leu 
        35                  40                  45              


Lys Tyr Leu Gly Ala Thr Ala Lys His Val Asn Gly Val Ala Lys Arg 
    50                  55                  60                  


Lys Gln Asn Phe Leu Ser Gln Ile Ser Leu Ile Pro Thr Asn Pro Gln 
65                  70                  75                  80  


Leu Pro His Gln Thr Ile Ile Asn Thr Tyr Leu Tyr Trp Gln Pro 
                85                  90                  95  


<210>  5
<211>  204
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Met Asn Arg Leu Lys Glu Leu Arg Lys Glu Lys Lys Leu Thr Gln Glu 
1               5                   10                  15      


Glu Leu Ala Gly Glu Ile Gly Val Ser Lys Ile Thr Ile Leu Arg Trp 
            20                  25                  30          


Glu Asn Gly Glu Arg Gln Ile Lys Pro Asp Lys Ala Lys Glu Leu Ala 
        35                  40                  45              


Lys Tyr Phe Asn Val Ser Val Gly Tyr Leu Leu Gly Tyr Ala Pro Asn 
    50                  55                  60                  


Lys Lys Ile Asp Phe Gln Leu Asn Leu Asp Gly Thr Thr Leu His Leu 
65                  70                  75                  80  


Thr Lys Glu Gln Phe Leu Ala Leu Glu Asn Thr Ser Lys Ser Ile Lys 
                85                  90                  95      


Lys Ile Lys Asn Thr Ile Asn Glu Ser Val Lys Gln Glu Glu Tyr Ile 
            100                 105                 110         


Lys Asn Ala Ser Lys Tyr Tyr Asp Phe Glu Lys Val Ser Arg Arg Leu 
        115                 120                 125             


Thr Asp Arg Leu Phe Glu Ile His Thr Asp Leu Ile Glu Leu Leu Met 
    130                 135                 140                 


Met Leu Asp His Phe Pro Ser Gly Glu Leu Ser Lys Ser Gln Gln Glu 
145                 150                 155                 160 


Ala Ile Phe Lys Phe Tyr Lys Gln Leu Asp Tyr Phe Val Thr Asp Thr 
                165                 170                 175     


Pro Ala Ser Phe Asp Tyr Phe Lys Lys Asn Leu Glu Ser Tyr Gly Tyr 
            180                 185                 190         


Lys Ile Tyr Thr Glu Gly Asp Lys Ile Asp Phe Asp 
        195                 200                 


<210>  6
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Met Leu Tyr Ile Asp Glu Phe Lys Glu Ala Ile Asp Lys Gly Tyr Ile 
1               5                   10                  15      


Leu Gly Gly Thr Val Ala Ile Val Arg Lys Asn Gly Lys Ile Phe Asp 
            20                  25                  30          


Tyr Val Leu Pro His Glu Glu Val Arg Glu Glu Glu Val Val Thr Val 
        35                  40                  45              


Glu Arg Val Glu Asp Val Met Arg Glu Leu Glu 
    50                  55                  


<210>  7
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Met Ile Lys Ile Tyr Phe Gly Lys Asp Ala Ala Leu Asn Gln Ala Ile 
1               5                   10                  15      


Gln Ser Arg Leu Asp Ser Tyr Gln Ile Asp Tyr Gln Ala Phe Ser Ser 
            20                  25                  30          


Lys Asp Ile Asp Ala Lys Thr Leu Met Glu Trp Leu Phe Lys Ser Thr 
        35                  40                  45              


Asp Ile Phe Glu Leu Leu Ser Thr Lys Met Leu Lys Tyr Lys Leu Asn 
    50                  55                  60                  


Thr Gln Ile Thr Leu Ser Gln Phe Val Arg Lys Ile Leu Lys Asp Val 
65                  70                  75                  80  


Asn Ser Thr Leu Lys Leu Pro Ile Val Val Thr Asp Glu Val Ile Tyr 
                85                  90                  95      


Ser Asn Met Ser Pro Asp Tyr Val Thr Val Leu Leu Pro Lys Glu Tyr 
            100                 105                 110         


Arg Lys Ile Lys Arg Ile Gln Leu Met Arg Lys Met Glu Gln Leu Asp 
        115                 120                 125             


Glu Gly Arg Leu Phe Trp Lys Asn Phe Glu Leu Phe Arg Lys Gln Ser 
    130                 135                 140                 


Glu Leu Arg Trp Phe Glu Leu Asn Glu Leu Leu Phe Ala Asp Val Ser 
145                 150                 155                 160 


Asp Asp Leu Gly Glu Ile Lys Lys Ala Lys Asp Arg Phe Phe Ser Tyr 
                165                 170                 175     


Lys Lys Asn Asn Gln Val Pro Pro Asn Glu Ile Ile Glu Arg Ile Leu 
            180                 185                 190         


Lys Ile Phe Leu Val Asp Arg Glu Asp Phe Phe Lys Lys Ser Pro Ser 
        195                 200                 205             


Asp Leu Gln Asn Phe 
    210             


<210>  8
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Met Asp Tyr Asp Asn Glu Asn Tyr Leu Ile Pro Lys Ile Leu Leu Gln 
1               5                   10                  15      


Asp Asp Phe Tyr Ser Ser Leu Ser Ala Lys Asp Ile Leu Val Tyr Ala 
            20                  25                  30          


Val Leu Lys Asp Arg Gln Ile Glu Ala Leu Glu Lys Gly Trp Ile Asp 
        35                  40                  45              


Thr Asp Gly Ser Ile Tyr Leu Asn Phe Lys Leu Ile Glu Leu Ala Lys 
    50                  55                  60                  


Met Phe Ser Cys Ser Arg Thr Thr Met Ile Asp Val Met Gln Arg Leu 
65                  70                  75                  80  


Glu Glu Val Asn Leu Ile Glu Arg Glu Arg Val Asp Val Phe Tyr Gly 
                85                  90                  95      


Tyr Ser Leu Pro Tyr Lys Thr Tyr Ile Asn Glu Val 
            100                 105             


<210>  9
<211>  93
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Met Thr Glu Gly Phe Thr Ile Gln Leu Pro Lys Val Thr Glu Lys Lys 
1               5                   10                  15      


Leu Leu Ala Arg Tyr Asp Asp Met Leu Gln Lys Ala Ile Glu Lys Ala 
            20                  25                  30          


Leu Glu Asp Lys Glu Leu Tyr Lys Pro Ile Val Arg Met Ala Gly Leu 
        35                  40                  45              


Cys Arg Trp Leu Asp Val Ser Thr Thr Thr Val Val Lys Trp Gln Lys 
    50                  55                  60                  


Gln Gly Gly Met Pro His Met Val Ile Asp Gly Val Thr Leu Tyr Asp 
65                  70                  75                  80  


Lys His Lys Val Ala Gln Trp Leu Gln Gln Phe Glu Arg 
                85                  90              


<210>  10
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Met Asn Ile Glu Asp Ile Glu Arg Ile Ile Ser Glu Tyr Leu Ile Phe 
1               5                   10                  15      


Arg Ser Asp Ile Asp Gly Cys Ala Val Ile Asp Ile Glu Asp Phe Leu 
            20                  25                  30          


Lys His Ile Arg Phe Ser Tyr Glu Arg Leu Lys 
        35                  40              


<210>  11
<211>  7
<212>  PRT
<213>  SV40 virus

<400>  11

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  12
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  nucleoplasmin bipartite NLS

<400>  12

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  13
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  c-myc NLS

<400>  13

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  14
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  c-myc NLS

<400>  14

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  15
<211>  38
<212>  PRT
<213>  Unknown

<220>
<223>  hRNPA1 M9 NLS

<400>  15

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  16
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  IBB domain from importin-alpha

<400>  16

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  17
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  myoma T protein

<400>  17

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  myoma T protein

<400>  18

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  20
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  20

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  21
<211>  5
<212>  PRT
<213>  Influenza virus

<400>  21

Asp Arg Leu Arg Arg 
1               5   


<210>  22
<211>  7
<212>  PRT
<213>  Influenza virus

<400>  22

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  23
<211>  10
<212>  PRT
<213>  Hepatitus virus

<400>  23

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  24

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  25
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  26
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  27
<211>  11
<212>  PRT
<213>  HIV-1

<400>  27

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  28
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  29
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  30
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  31
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  32
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  34
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  37
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  The amino acids at positions 1 to 5 repeat n times, where n is an
       integer of at least one

<400>  37

Gly Ser Gly Gly Ser 
1               5   


<210>  38
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  REPEAT
<222>  (1)..(6)
<223>  The amino acids at positions 1 to 6 repeat n times, where n is an
       integer of at least one

<400>  38

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  39
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  The amino acids at positions 1 to 5 repeat n times, where n is an
       integer of at least one

<400>  39

Gly Gly Gly Gly Ser 
1               5   


<210>  40
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  40

Gly Gly Ser Gly 
1               


<210>  41
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  41

Gly Gly Ser Gly Gly 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  42

Gly Ser Gly Ser Gly 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  43

Gly Ser Gly Gly Gly 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  44

Gly Gly Gly Ser Gly 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  45

Gly Ser Ser Ser Gly 
1               5   


<210>  46
<211>  20
<212>  DNA
<213>  Streptococcus pyogenes, Streptococcus iniae

<400>  46
gatggtaagc cctcccgtat                                                   20


<210>  47
<211>  24
<212>  DNA
<213>  Acidaminococcus sp.

<400>  47
acgttttcca atgatgagca cttt                                              24


<210>  48
<211>  19
<212>  DNA
<213>  Staphylococcus aureus

<400>  48
tatcgtagtt atctacacg                                                    19


<210>  49
<211>  30
<212>  DNA
<213>  Streptococcus iniae

<400>  49
ttgataagta taatttcctg tctttgtttt                                        30


<210>  50
<211>  30
<212>  DNA
<213>  Streptococcus iniae

<400>  50
taaggaattt gaagcaatac gtcttaattt                                        30


<210>  51
<211>  30
<212>  DNA
<213>  Streptococcus iniae

<400>  51
caaaaaagtt cggtaactta cggtaactta                                        30


<210>  52
<211>  30
<212>  DNA
<213>  Streptococcus iniae

<400>  52
tctaaaaaat caaaagttac cgtgttaccg                                        30


<210>  53
<211>  30
<212>  DNA
<213>  Streptococcus iniae

<400>  53
aatatgactt ttgggaaatt aactaatcaa                                        30


<210>  54
<211>  30
<212>  DNA
<213>  Streptococcus iniae

<400>  54
tttttgagtg tactgatgtt gcttttgagc                                        30


<210>  55
<211>  30
<212>  DNA
<213>  Streptococcus iniae

<400>  55
ataatcaatc acattaatgc tgacatcaac                                        30


<210>  56
<211>  30
<212>  DNA
<213>  Streptococcus iniae

<400>  56
gagtttaatt aagtgacata atatcttcat                                        30


<210>  57
<211>  30
<212>  DNA
<213>  Streptococcus pyogenes

<400>  57
tcgtcagatt tgtcagtata gtaatcatca                                        30


<210>  58
<211>  30
<212>  DNA
<213>  Streptococcus pyogenes

<400>  58
ctatattgtt gagctgtggg ctttgcataa                                        30


<210>  59
<211>  30
<212>  DNA
<213>  Streptococcus pyogenes

<400>  59
gtaataatag cattgcctgt tctatcctgt                                        30


<210>  60
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  60
tatttgatag cggtaacggg tcatatacaa                                        30


<210>  61
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  61
tggtggtatt tataatgtac gagcaaatcg                                        30


<210>  62
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  62
accttgctcc gatgacacca tcgcgaacct                                        30


<210>  63
<211>  30
<212>  DNA
<213>  Streptococcus pyogenes

<400>  63
atcgtaaggc aacagattat cgtaagatct                                        30


<210>  64
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  64
atttgcaact ttctcaagtg ttgcgagaga                                        30


<210>  65
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  65
gcaagcacta aatgaagcta ctagacttaa                                        30


<210>  66
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  66
taatgacatg tggattgata tctcagagaa                                        30


<210>  67
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  67
tgtcattgtt aaaatcattt gcatattttt                                        30


<210>  68
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  68
tacttgacga attgaagatg acggaattta                                        30


<210>  69
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  69
aaggcacgcg caagatgaat tcatttctaa                                        30


<210>  70
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  70
tgatgttctt tatcaaacat tctaaatact                                        30


<210>  71
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  71
gagccttgct tgagtttgtg gagctttata                                        30


<210>  72
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  72
gtataattta gttaagctta aatttaacca                                        30


<210>  73
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  73
gaaaaaggcg atgtagctta gaaaggagaa                                        30


<210>  74
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  74
tacgaaaagg ttgtgataaa agccatatca                                        30


<210>  75
<211>  33
<212>  DNA
<213>  Streptococcus agalactiae

<400>  75
aacaactttc ttacaaaagg ttctagtttt ctt                                    33


<210>  76
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  76
acgctctgag gcagatgagg aacaggcgca                                        30


<210>  77
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  77
tgaaaacaag cgcaaagctg tcagaaaaca                                        30


<210>  78
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  78
gaaacttcga ttagtttgcg tactcgctca                                        30


<210>  79
<211>  31
<212>  DNA
<213>  Streptococcus agalactiae

<400>  79
ttgctgctag acccaaacag tttattttta g                                      31


<210>  80
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  80
tatttcatca tagaaaatcc tgctagtggt                                        30


<210>  81
<211>  32
<212>  DNA
<213>  Streptococcus agalactiae

<400>  81
acacctagtt tcaagttttt agcagatttt tt                                     32


<210>  82
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  82
attgactgtt tacgatttcc ttccaccgtt                                        30


<210>  83
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  83
tgatgagatt tttaaaagac tcactgatat                                        30


<210>  84
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  84
cgcttagatg aagtacagat tgtaacaagt                                        30


<210>  85
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  85
aacacagctt cctcgaaagg gatatatcta                                        30


<210>  86
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  86
attaagttgc ttagtgcttt cataatcatc                                        30


<210>  87
<211>  30
<212>  DNA
<213>  Streptococcus agalactiae

<400>  87
ttccatttct gatttgattc aacagcagca                                        30


<210>  88
<211>  30
<212>  DNA
<213>  Streptococcus oralis

<400>  88
tacagcggat acaaccccac caatagcctc                                        30


<210>  89
<211>  30
<212>  DNA
<213>  Streptococcus pasteurianus

<400>  89
tttattcggc atcggctggt gttatggact                                        30


<210>  90
<211>  30
<212>  DNA
<213>  Streptococcus pyogenes

<400>  90
tagagtaaac cgaatctttg ccatctctgg                                        30


<210>  91
<211>  29
<212>  DNA
<213>  Streptococcus pyogenes

<400>  91
tggtctaact gcgtctggtc tgtgaatga                                         29


<210>  92
<211>  30
<212>  DNA
<213>  Listeria monocytogenes

<400>  92
ggtaaaacaa gcatcggcga agcagtaaca                                        30


<210>  93
<211>  30
<212>  DNA
<213>  Listeria monocytogenes

<400>  93
taggtttagg gagtaaatta gctcctttgg                                        30


<210>  94
<211>  30
<212>  DNA
<213>  Listeria monocytogenes

<400>  94
taactttaga tactgctaaa gaattagcaa                                        30


<210>  95
<211>  30
<212>  DNA
<213>  Listeria monocytogenes

<400>  95
ttgggcaaaa tgaccgtaat aaatccattc                                        30


<210>  96
<211>  66
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  n is a, c, g, or u

<400>  96
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn guuuuagagc uguguuauuu ugaauggucc       60

caaaac                                                                  66


<210>  97
<211>  72
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  97
aacacagcaa guuaaaauaa ggcuugucgu aaucaaccuu gaaaaaguga acaccgauuc       60

gguguuuuuu uu                                                           72


<210>  98
<211>  111
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  98
nnnnnnnnnn nnnnnnnnnn guuuuagagc uguguugaaa aacacagcaa guuaaaauaa       60

ggcuuguccg uaaucaacuu gaaaaaguga acaccgauuc gguguuuuuu u               111


<210>  99
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  99
cgttcgtaag tagcctagat aaataaaata atc                                    33


<210>  100
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  100
aataatggtt tcttagacgt caggtggc                                          28


<210>  101
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  101
gtcgaaatta atacgactca ctataggccg tatctgatga ggccttcggg ccg              53


<210>  102
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  102
gatgaggcct tcgggccgaa acggtgaaag ccgtaatacg ggag                        44


<210>  103
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  103
gaaagccgta atacgggagg gcttaccatc gttttagagc tatgctgttt tggaaacaa        59


<210>  104
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  104
atgctgtttt ggaaacaaaa cagcatagca agttaaaata aggctagtcc gttatcaac        59


<210>  105
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  105
aaaaaaagca ccgactcggt gccacttttt caagttgata acggactagc ctt              53


<210>  106
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  106
aaaaatctcg ccaacaagtt gacgagataa acacggcatt ttgccttgtt ttag             54


<210>  107
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  107
gccgtaatac gggagggctt accatcgttt tagagctgtg ttgaaaaac                   49


<210>  108
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  108
cgttttagag ctgtgttgaa aaacacagca agttaaaata aggcttgtcc gtaatcaac        59


<210>  109
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  109
aaaaaaacac cgaatcggtg ttcacttttt caagttgatt acggacaagc c                51


<210>  110
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  110
tatacacctg caatatcatt gcattggatt ggaagtacag g                           41


<210>  111
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  111
tatacacctg cctaatatga ttggaagtgg ataacggatc c                           41


<210>  112
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  112
tatacacctg caatagcatt gcattggatt ggaagtacag g                           41


<210>  113
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  113
tatacacctg cctaatggga ttggaagtgg ataacggatc c                           41


<210>  114
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  114
tatacacctg cccaacccat tatttccctc caagtttgga caaatc                      46


<210>  115
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  115
tatacacctg catacatgcg taaaccttat tcaattggac ttg                         43


<210>  116
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  116
tatacacctg cctgataaat ggcattcgca acaaagaaaa tc                          42


<210>  117
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  117
tatacacctg cgccatttat cagtttagca gaaaggcgtc c                           41


<210>  118
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  118
tatacacctg ccactagatt ttgcaaagat aataaagcat gagcaag                     47


<210>  119
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  119
tatacacctg ccaaaatcta gtgaagaatc attaattaat tgcatgaagt ttc              53


<210>  120
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  120
tatacacctg cagttatgaa taagccttat tccattggct tagatattg                   49


<210>  121
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  121
tatacacctg cctgccatat cagtcttccc ctaacttccc                             40


<210>  122
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  122
gctgacaatg atacgaacga gacacacgct cacgactcag                             40


<210>  123
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  123
ctgagtcgtg agcgtgtgtc tcgttcgtat cattgtcagc                             40


<210>  124
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  124
gtcgaaatta atacgactca ctataggcta cgatactgat gaggccttcg ggcc             54


<210>  125
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  125
gaggccttcg ggccgaaacg gtgaaagccg tatatcgtag ttatctacac gac              53


<210>  126
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  126
cgtatatcgt agttatctac acgacggttt tagtactctg gaaacagaat ctac             54


<210>  127
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  127
gttttagtac tctggaaaca gaatctacta aaacaaggca aaatgccg                    48


<210>  128
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  128

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  129
<211>  1054
<212>  PRT
<213>  Staphylococcus aureus

<400>  129

Met Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser 
1               5                   10                  15      


Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala 
            20                  25                  30          


Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg 
        35                  40                  45              


Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg 
    50                  55                  60                  


Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp 
65                  70                  75                  80  


His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly 
                85                  90                  95      


Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His 
            100                 105                 110         


Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp 
        115                 120                 125             


Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys 
    130                 135                 140                 


Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys 
145                 150                 155                 160 


Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp 
                165                 170                 175     


Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His 
            180                 185                 190         


Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr 
        195                 200                 205             


Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp 
    210                 215                 220                 


Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu 
                245                 250                 255     


Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu 
            260                 265                 270         


Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile 
    290                 295                 300                 


Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly 
305                 310                 315                 320 


Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile 
                325                 330                 335     


Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile 
            340                 345                 350         


Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu 
        355                 360                 365             


Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile 
    370                 375                 380                 


Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala 
385                 390                 395                 400 


Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile 
                405                 410                 415     


Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser 
            420                 425                 430         


Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala 
    450                 455                 460                 


Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr 
            500                 505                 510         


Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His 
        515                 520                 525             


Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr 
            580                 585                 590         


Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His 
        595                 600                 605             


Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys 
625                 630                 635                 640 


Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly 
                645                 650                 655     


Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val 
            660                 665                 670         


Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys 
705                 710                 715                 720 


Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu 
                725                 730                 735     


Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys 
            740                 745                 750         


Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys 
        755                 760                 765             


Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu 
    770                 775                 780                 


Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr 
785                 790                 795                 800 


Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys 
                805                 810                 815     


Leu Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His 
            820                 825                 830         


His Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr 
        835                 840                 845             


Gly Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn 
    850                 855                 860                 


Tyr Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys 
865                 870                 875                 880 


Ile Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp 
                885                 890                 895     


Asp Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro 
            900                 905                 910         


Tyr Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr 
        915                 920                 925             


Val Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn 
    930                 935                 940                 


Ser Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln 
945                 950                 955                 960 


Ala Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn 
                965                 970                 975     


Gly Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg 
            980                 985                 990         


Ile Glu Val Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
        995                 1000                 1005             


Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile Lys Thr  Ile Ala Ser 
    1010                 1015                 1020             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1025                 1030                 1035             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1040                 1045                 1050             


Gly 
    


<210>  130
<211>  1368
<212>  PRT
<213>  Streptococcus iniae

<400>  130

Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 
            20                  25                  30          


Arg Ile Gln Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 
65                  70                  75                  80  


Glu Leu Gln Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 
                85                  90                  95      


Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 
            100                 105                 110         


Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 
        115                 120                 125             


His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gln Thr Leu Ala Asp 
    130                 135                 140                 


Arg Asp Gln Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 
                165                 170                 175     


Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 
            180                 185                 190         


Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 
        195                 200                 205             


Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Glu Ile Pro Asn Gln Lys Arg Asn Met Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 
                245                 250                 255     


Glu Leu Leu Glu Asp Ala Lys Leu Gln Ile Ser Lys Asp Ser Tyr Glu 
            260                 265                 270         


Glu Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Val Gln Arg Tyr Glu Glu His Gln Gln Asp Leu Ala Leu Leu Lys 
                325                 330                 335     


Asn Leu Val Lys Lys Gln Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 
            340                 345                 350         


Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asn 
    370                 375                 380                 


Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Asn Glu Leu Lys Ala Ile Ile Arg Arg Gln Glu Lys Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Glu Asn Gln Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gln Ser Ser Phe Ala Trp 
    450                 455                 460                 


Leu Lys Arg Gln Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Gln Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Gln Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 
    530                 535                 540                 


Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Asp Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 
                565                 570                 575     


Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 
        595                 600                 605             


Asp Glu Ala Asn Gln Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Gln Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 
625                 630                 635                 640 


Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Gln Lys Leu Ile Asn Gly Ile Lys Asp 
            660                 665                 670         


Lys Gln Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile Asn Asp Ser Ser Leu Asp Phe 
    690                 695                 700                 


Ala Lys Ile Ile Lys His Glu Gln Glu Lys Thr Ile Lys Asn Glu Ser 
705                 710                 715                 720 


Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
                725                 730                 735     


Gly Ile Leu Gln Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 
            740                 745                 750         


Gly Gln Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Ser Thr Met Gln Gly Ile Lys Asn Ser Arg Gln Arg Leu Arg Lys Leu 
    770                 775                 780                 


Glu Glu Val His Lys Asn Thr Gly Ser Lys Ile Leu Lys Glu Tyr Asn 
785                 790                 795                 800 


Val Ser Asn Thr Gln Leu Gln Ser Asp Arg Leu Tyr Leu Tyr Leu Leu 
                805                 810                 815     


Gln Asp Gly Lys Asp Met Tyr Thr Gly Lys Glu Leu Asp Tyr Asp Asn 
            820                 825                 830         


Leu Ser Gln Tyr Asp Ile Asp His Ile Ile Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asn Ser Ile Asp Asn Ile Val Leu Thr Thr Gln Ala Ser Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Asn Ile Glu Ile Val Asn Lys Met Lys 
865                 870                 875                 880 


Ser Phe Trp Tyr Lys Gln Leu Lys Asn Gly Ala Ile Ser Gln Arg Lys 
                885                 890                 895     


Phe Asp His Leu Thr Lys Ala Glu Arg Gly Ala Leu Ser Asp Phe Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Phe Asn Ser Asn Leu Thr 
    930                 935                 940                 


Glu Asp Ser Lys Ser Asn Arg Asn Val Lys Ile Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Met Val Ser Asp Phe Arg Lys Asp Phe Gly Phe Tyr Lys Leu Arg 
                965                 970                 975     


Glu Val Asn Asp Tyr His His Ala Gln Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Leu Lys Lys  Tyr Pro Lys Leu Glu  Ala Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys His  Tyr Asp Leu Ala Lys  Leu Met Ile 
    1010                 1015                 1020             


Gln Pro  Asp Ser Ser Leu Gly  Lys Ala Thr Thr Arg  Met Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Leu Met Asn Phe  Phe Lys Lys Glu Ile  Lys Leu Ala 
    1040                 1045                 1050             


Asp Asp  Thr Ile Phe Thr Arg  Pro Gln Ile Glu Val  Asn Thr Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Val Lys Asp Met  Gln Thr Ile 
    1070                 1075                 1080             


Arg Lys  Val Met Ser Tyr Pro  Gln Val Asn Ile Val  Met Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Gly Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Ser  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Ile Ile Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Ile Ala  Lys Gly Lys Thr Gln  Lys Leu Lys 
    1145                 1150                 1155             


Thr Ile  Lys Glu Leu Val Gly  Ile Lys Ile Met Glu  Gln Asp Glu 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Ala  Phe Leu Glu Lys Lys  Gly Tyr Gln 
    1175                 1180                 1185             


Asp Ile  Gln Thr Ser Ser Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Leu Leu Ala  Ser Ala Lys 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Asn  Lys Tyr Val 
    1220                 1225                 1230             


Lys Phe  Leu Tyr Leu Ala Ser  His Tyr Thr Lys Phe  Thr Gly Lys 
    1235                 1240                 1245             


Glu Glu  Asp Arg Glu Lys Lys  Arg Ser Tyr Val Glu  Ser His Leu 
    1250                 1255                 1260             


Tyr Tyr  Phe Asp Glu Ile Met  Gln Ile Ile Val Glu  Tyr Ser Asn 
    1265                 1270                 1275             


Arg Tyr  Ile Leu Ala Asp Ser  Asn Leu Ile Lys Ile  Gln Asn Leu 
    1280                 1285                 1290             


Tyr Lys  Glu Lys Asp Asn Phe  Ser Ile Glu Glu Gln  Ala Ile Asn 
    1295                 1300                 1305             


Met Leu  Asn Leu Phe Thr Phe  Thr Asp Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Phe Phe Asn Gly Asp  Ile Asp Arg Lys Arg  Tyr Ser Ser 
    1325                 1330                 1335             


Thr Asn  Glu Ile Ile Asn Ser  Thr Leu Ile Tyr Gln  Ser Pro Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Lys Leu  Gly Gly Lys 
    1355                 1360                 1365             


<210>  131
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp.

<400>  131

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  132
<211>  123
<212>  DNA
<213>  Streptococcus pyogenes

<400>  132
atacgggagg gcttaccatc gttttagagc tatgctgttt tggaaacaaa acagcatagc       60

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt      120

ttt                                                                    123


<210>  133
<211>  103
<212>  DNA
<213>  Staphylococcus aureus

<400>  133
tatcgtagtt atctacacga cggttttagt actctggaaa cagaatctac taaaacaagg       60

caaaatgccg tgtttatctc gtcaacttgt tggcgagatt ttt                        103


<210>  134
<211>  111
<212>  DNA
<213>  Streptococcus iniae

<400>  134
atacgggagg gcttaccatc gttttagagc tgtgttgaaa aacacagcaa gttaaaataa       60

ggcttgtccg taatcaactt gaaaaagtga acaccgattc ggtgtttttt t               111


<210>  135
<211>  43
<212>  RNA
<213>  Acidaminococcus sp.

<400>  135
aauuucuacu cuuguagaua aagugcucau cauuggaaaa cgu                         43


<210>  136
<211>  2182
<212>  DNA
<213>  Streptococcus pyogenes, Staphylococcus aureus, Streptococcus iniae, Acidaminococcus sp.

<400>  136
aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat       60

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata      120

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct      180

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa      240

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa      300

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt      360

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg      420

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca      480

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa      540

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt      600

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc      660

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa      720

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga      780

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc      840

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga      900

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga      960

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     1020

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     1080

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     1140

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     1200

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     1260

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     1320

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     1380

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     1440

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     1500

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     1560

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     1620

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     1680

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     1740

atgctcgtca ggggggcgga gcctgtggaa aaacgccagc aacgcggcct ttttacggtt     1800

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     1860

ggataaccgt attaccgcag agtttgtaga aacgcaaaaa ggccatccgt caggatggcc     1920

ttctgcttaa tttgatgcct ggcagtttat ggcgggcgtc ctgcccgcca ccctccgggc     1980

cgttgcttcg caacgttcaa atccgctccc ggcggttgag aagagaaaag aaaaccgccg     2040

atcctgtcca ccgcattact gcaaggtagt ggacaagacc ggcggtctta agttttttgg     2100

ctgaaatgcc tggcagttcc ctactctcgc atggggctcg cggttaactg attattttat     2160

ttatctaggc tacttacgaa cg                                              2182


