                         SEQUENCE LISTING

<110>  Ohio State Innovation Foundation
 
<120>  METHODS AND COMPOSITIONS FOR CARDIOVASCULAR DISEASE DETECTION AND
        MANAGEMENT

<130>  10336-690WO1

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  2363
<212>  PRT
<213>  Mus musculus

<400>  1

Met Thr Thr Thr Val Ala Thr Asp Tyr Asp Asn Ile Glu Ile Gln Gln 
1               5                   10                  15      


Gln Tyr Ser Asp Val Asn Asn Arg Trp Asp Val Asp Asp Trp Asp Asn 
            20                  25                  30          


Glu Asn Ser Ser Ala Arg Leu Phe Glu Arg Ser Arg Ile Lys Ala Leu 
        35                  40                  45              


Ala Asp Glu Arg Glu Ala Val Gln Lys Lys Thr Phe Thr Lys Trp Val 
    50                  55                  60                  


Asn Ser His Leu Ala Arg Val Ser Cys Arg Ile Thr Asp Leu Tyr Thr 
65                  70                  75                  80  


Asp Leu Arg Asp Gly Arg Met Leu Ile Lys Leu Leu Glu Val Leu Ser 
                85                  90                  95      


Gly Glu Arg Leu Pro Lys Pro Thr Lys Gly Arg Met Arg Ile His Cys 
            100                 105                 110         


Leu Glu Asn Val Asp Lys Ala Leu Gln Phe Leu Lys Glu Gln Arg Val 
        115                 120                 125             


His Leu Glu Asn Met Gly Ser His Asp Ile Val Asp Gly Asn His Arg 
    130                 135                 140                 


Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu Arg Phe Gln Ile Gln 
145                 150                 155                 160 


Asp Ile Ser Val Glu Thr Glu Asp Asn Lys Glu Lys Lys Ser Ala Lys 
                165                 170                 175     


Asp Ala Leu Leu Leu Trp Cys Gln Met Lys Thr Ala Gly Tyr Pro Asn 
            180                 185                 190         


Val Asn Ile His Asn Phe Thr Thr Ser Trp Arg Asp Gly Met Ala Phe 
        195                 200                 205             


Asn Ala Leu Ile His Lys His Arg Pro Asp Leu Ile Asp Phe Asp Lys 
    210                 215                 220                 


Leu Lys Lys Ser Asn Ala His Tyr Asn Leu Gln Asn Ala Phe Asn Leu 
225                 230                 235                 240 


Ala Glu Gln His Leu Gly Leu Thr Lys Leu Leu Asp Pro Glu Asp Ile 
                245                 250                 255     


Ser Val Asp His Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Val Thr 
            260                 265                 270         


Tyr Tyr His Tyr Phe Ser Lys Met Lys Ala Leu Ala Val Glu Gly Lys 
        275                 280                 285             


Arg Ile Gly Lys Val Leu Asp Asn Ala Ile Glu Thr Glu Lys Met Ile 
    290                 295                 300                 


Glu Lys Tyr Glu Ser Leu Ala Ser Asp Leu Leu Glu Trp Ile Glu Gln 
305                 310                 315                 320 


Thr Ile Ile Ile Leu Asn Asn Arg Lys Phe Ala Asn Ser Leu Val Gly 
                325                 330                 335     


Val Gln Gln Gln Leu Gln Ala Phe Asn Thr Tyr Arg Thr Val Glu Lys 
            340                 345                 350         


Pro Pro Lys Phe Thr Glu Lys Gly Asn Leu Glu Val Leu Leu Phe Thr 
        355                 360                 365             


Ile Gln Ser Lys Met Arg Ala Asn Asn Gln Lys Val Tyr Met Pro Arg 
    370                 375                 380                 


Glu Gly Lys Leu Ile Ser Asp Ile Asn Lys Ala Trp Glu Arg Leu Glu 
385                 390                 395                 400 


Lys Ala Glu His Glu Arg Glu Leu Ala Leu Arg Asn Glu Leu Ile Arg 
                405                 410                 415     


Gln Glu Lys Leu Glu Gln Leu Ala Arg Arg Phe Asp Arg Lys Ala Ala 
            420                 425                 430         


Met Arg Glu Thr Trp Leu Ser Glu Asn Gln Arg Leu Val Ser Gln Asp 
        435                 440                 445             


Asn Phe Gly Phe Asp Leu Pro Ala Val Glu Ala Ala Thr Lys Lys His 
    450                 455                 460                 


Glu Ala Ile Glu Thr Asp Ile Ala Ala Tyr Glu Glu Arg Val Gln Ala 
465                 470                 475                 480 


Val Val Ala Val Ala Arg Glu Leu Glu Ala Glu Asn Tyr His Asp Ile 
                485                 490                 495     


Lys Arg Ile Thr Ala Arg Lys Asp Asn Val Ile Arg Leu Trp Glu Tyr 
            500                 505                 510         


Leu Leu Glu Leu Leu Arg Ala Arg Arg Gln Arg Leu Glu Met Asn Leu 
        515                 520                 525             


Gly Leu Gln Lys Ile Phe Gln Glu Met Leu Tyr Ile Met Asp Trp Met 
    530                 535                 540                 


Asp Glu Met Lys Val Leu Leu Leu Ser Gln Asp Tyr Gly Lys His Leu 
545                 550                 555                 560 


Leu Gly Val Glu Asp Leu Leu Gln Lys His Ala Leu Val Glu Ala Asp 
                565                 570                 575     


Ile Ala Ile Gln Ala Glu Arg Val Arg Gly Val Asn Ala Ser Ala Gln 
            580                 585                 590         


Lys Phe Ala Thr Asp Gly Glu Gly Tyr Lys Pro Cys Asp Pro Gln Val 
        595                 600                 605             


Ile Arg Asp Arg Val Ala His Met Glu Phe Cys Tyr Gln Glu Leu Cys 
    610                 615                 620                 


Gln Leu Ala Ala Glu Arg Arg Ala Arg Leu Glu Glu Ser Arg Arg Leu 
625                 630                 635                 640 


Trp Lys Phe Phe Trp Glu Met Ala Glu Glu Glu Gly Trp Ile Arg Glu 
                645                 650                 655     


Lys Glu Lys Ile Leu Ser Ser Asp Asp Tyr Gly Lys Asp Leu Thr Ser 
            660                 665                 670         


Val Met Arg Leu Leu Ser Lys His Arg Ala Phe Glu Asp Glu Met Ser 
        675                 680                 685             


Gly Arg Ser Gly His Phe Glu Gln Ala Ile Lys Glu Gly Glu Asp Met 
    690                 695                 700                 


Ile Ala Glu Glu His Phe Gly Ser Glu Lys Ile Arg Glu Arg Ile Ile 
705                 710                 715                 720 


Tyr Ile Arg Glu Gln Trp Ala Asn Leu Glu Gln Leu Ser Ala Ile Arg 
                725                 730                 735     


Lys Lys Arg Leu Glu Glu Ala Ser Leu Leu His Gln Phe Gln Ala Asp 
            740                 745                 750         


Ala Asp Asp Ile Asp Ala Trp Met Leu Asp Ile Leu Lys Ile Val Ser 
        755                 760                 765             


Ser Asn Asp Val Gly His Asp Glu Tyr Ser Thr Gln Ser Leu Val Lys 
    770                 775                 780                 


Lys His Lys Asp Val Ala Glu Glu Ile Thr Asn Tyr Arg Pro Thr Ile 
785                 790                 795                 800 


Asp Thr Leu His Glu Gln Ala Ser Ala Leu Pro Gln Ala His Ala Glu 
                805                 810                 815     


Ser Pro Asp Val Lys Gly Arg Leu Ala Gly Ile Glu Glu Arg Cys Lys 
            820                 825                 830         


Glu Met Ala Glu Leu Thr Arg Leu Arg Lys Gln Ala Leu Gln Asp Thr 
        835                 840                 845             


Leu Ala Leu Tyr Lys Met Phe Ser Glu Ala Asp Ala Cys Glu Leu Trp 
    850                 855                 860                 


Ile Asp Glu Lys Glu Gln Trp Leu Asn Asn Met Gln Ile Pro Glu Lys 
865                 870                 875                 880 


Leu Glu Asp Leu Glu Val Ile Gln His Arg Phe Glu Ser Leu Glu Pro 
                885                 890                 895     


Glu Met Asn Asn Gln Ala Ser Arg Val Ala Val Val Asn Gln Ile Ala 
            900                 905                 910         


Arg Gln Leu Met His Asn Gly His Pro Ser Glu Lys Glu Ile Arg Ala 
        915                 920                 925             


Gln Gln Asp Lys Leu Asn Thr Arg Trp Ser Gln Phe Arg Glu Leu Val 
    930                 935                 940                 


Asp Arg Lys Lys Asp Ala Leu Leu Ser Ala Leu Ser Ile Gln Asn Tyr 
945                 950                 955                 960 


His Leu Glu Cys Asn Glu Thr Lys Ser Trp Ile Arg Glu Lys Thr Lys 
                965                 970                 975     


Val Ile Glu Ser Thr Gln Asp Leu Gly Asn Asp Leu Ala Gly Val Met 
            980                 985                 990         


Ala Leu Gln Arg Lys Leu Thr Gly  Met Glu Arg Asp Leu  Val Ala Ile 
        995                 1000                 1005             


Glu Ala  Lys Leu Ser Asp Leu  Gln Lys Glu Ala Glu  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  His Pro Asp Gln Ala  Gln Ala Ile Leu Ser  Arg Leu Ala 
    1025                 1030                 1035             


Glu Ile  Ser Asp Val Trp Glu  Glu Met Lys Thr Thr  Leu Lys Asn 
    1040                 1045                 1050             


Arg Glu  Ala Ser Leu Gly Glu  Ala Ser Lys Leu Gln  Gln Phe Leu 
    1055                 1060                 1065             


Arg Asp  Leu Asp Asp Phe Gln  Ser Trp Leu Ser Arg  Thr Gln Thr 
    1070                 1075                 1080             


Ala Ile  Ala Ser Glu Asp Met  Pro Asn Thr Leu Thr  Glu Ala Glu 
    1085                 1090                 1095             


Lys Leu  Leu Thr Gln His Glu  Asn Ile Lys Asn Glu  Ile Asp Asn 
    1100                 1105                 1110             


Tyr Glu  Glu Asp Tyr Gln Lys  Met Arg Asp Met Gly  Glu Met Val 
    1115                 1120                 1125             


Thr Gln  Gly Gln Thr Asp Ala  Gln Tyr Met Phe Leu  Arg Gln Arg 
    1130                 1135                 1140             


Leu Gln  Ala Leu Asp Thr Gly  Trp Asn Glu Leu His  Lys Met Trp 
    1145                 1150                 1155             


Glu Asn  Arg Gln Asn Leu Leu  Ser Gln Ser His Ala  Tyr Gln Gln 
    1160                 1165                 1170             


Phe Leu  Arg Asp Thr Lys Gln  Ala Glu Ala Phe Leu  Asn Asn Gln 
    1175                 1180                 1185             


Glu Tyr  Val Leu Ala His Thr  Glu Met Pro Thr Thr  Leu Glu Gly 
    1190                 1195                 1200             


Ala Glu  Ala Ala Ile Lys Lys  Gln Glu Asp Phe Met  Thr Thr Met 
    1205                 1210                 1215             


Asp Ala  Asn Glu Glu Lys Ile  Asn Ala Val Val Glu  Thr Gly Arg 
    1220                 1225                 1230             


Arg Leu  Val Ser Asp Gly Asn  Ile Asn Ser Asp Arg  Ile Gln Glu 
    1235                 1240                 1245             


Lys Val  Asp Ser Ile Asp Asp  Arg His Arg Lys Asn  Arg Glu Ala 
    1250                 1255                 1260             


Ala Ser  Glu Leu Leu Met Arg  Leu Lys Asp Asn Arg  Asp Leu Gln 
    1265                 1270                 1275             


Lys Phe  Leu Gln Asp Cys Gln  Glu Leu Ser Leu Trp  Ile Asn Glu 
    1280                 1285                 1290             


Lys Met  Leu Thr Ala Gln Asp  Met Ser Tyr Asp Glu  Ala Arg Asn 
    1295                 1300                 1305             


Leu His  Ser Lys Trp Leu Lys  His Gln Ala Phe Met  Ala Glu Leu 
    1310                 1315                 1320             


Ala Ser  Asn Lys Glu Trp Leu  Asp Lys Ile Glu Lys  Glu Gly Met 
    1325                 1330                 1335             


Gln Leu  Ile Ser Glu Lys Pro  Glu Thr Glu Ala Val  Val Lys Glu 
    1340                 1345                 1350             


Lys Leu  Thr Gly Leu His Lys  Met Trp Glu Val Leu  Glu Ser Thr 
    1355                 1360                 1365             


Thr Gln  Thr Lys Ala Gln Arg  Leu Phe Asp Ala Asn  Lys Ala Glu 
    1370                 1375                 1380             


Leu Phe  Thr Gln Ser Cys Ala  Asp Leu Asp Lys Trp  Leu His Gly 
    1385                 1390                 1395             


Leu Glu  Ser Gln Ile Gln Ser  Asp Asp Tyr Gly Lys  Asp Leu Thr 
    1400                 1405                 1410             


Ser Val  Asn Ile Leu Leu Lys  Lys Gln Gln Met Leu  Glu Asn Gln 
    1415                 1420                 1425             


Met Glu  Val Arg Lys Lys Glu  Ile Glu Glu Leu Gln  Ser Gln Ala 
    1430                 1435                 1440             


Gln Ala  Leu Ser Gln Glu Gly  Lys Ser Thr Asp Glu  Val Asp Ser 
    1445                 1450                 1455             


Lys Arg  Leu Thr Val Gln Thr  Lys Phe Met Glu Leu  Leu Glu Pro 
    1460                 1465                 1470             


Leu Ser  Glu Arg Lys His Asn  Leu Leu Ala Ser Lys  Glu Ile His 
    1475                 1480                 1485             


Gln Phe  Asn Arg Asp Val Glu  Asp Glu Ile Leu Trp  Val Gly Glu 
    1490                 1495                 1500             


Arg Met  Pro Leu Ala Thr Ser  Thr Asp His Gly His  Asn Leu Gln 
    1505                 1510                 1515             


Thr Val  Gln Leu Leu Ile Lys  Lys Asn Gln Thr Leu  Gln Lys Glu 
    1520                 1525                 1530             


Ile Gln  Gly His Gln Pro Arg  Ile Asp Asp Ile Phe  Glu Arg Ser 
    1535                 1540                 1545             


Gln Asn  Ile Ile Thr Asp Ser  Ser Ser Leu Asn Ala  Glu Ala Ile 
    1550                 1555                 1560             


Arg Gln  Arg Leu Ala Asp Leu  Lys Gln Leu Trp Gly  Leu Leu Ile 
    1565                 1570                 1575             


Glu Glu  Thr Glu Lys Arg His  Arg Arg Leu Glu Glu  Ala His Lys 
    1580                 1585                 1590             


Ala Gln  Gln Tyr Tyr Phe Asp  Ala Ala Glu Ala Glu  Ala Trp Met 
    1595                 1600                 1605             


Ser Glu  Gln Glu Leu Tyr Met  Met Ser Glu Glu Lys  Ala Lys Asp 
    1610                 1615                 1620             


Glu Gln  Ser Ala Val Ser Met  Leu Lys Lys His Gln  Ile Leu Glu 
    1625                 1630                 1635             


Gln Ala  Val Glu Asp Tyr Ala  Glu Thr Val His Gln  Leu Ser Lys 
    1640                 1645                 1650             


Thr Ser  Arg Ala Leu Val Ala  Asp Ser His Pro Glu  Ser Glu Arg 
    1655                 1660                 1665             


Ile Ser  Met Arg Gln Ser Lys  Val Asp Lys Leu Tyr  Ala Gly Leu 
    1670                 1675                 1680             


Lys Asp  Leu Ala Glu Glu Arg  Arg Gly Lys Leu Asp  Glu Arg His 
    1685                 1690                 1695             


Arg Leu  Phe Gln Leu Asn Arg  Glu Val Asp Asp Leu  Glu Gln Trp 
    1700                 1705                 1710             


Ile Ala  Glu Arg Glu Val Val  Ala Gly Ser His Glu  Leu Gly Gln 
    1715                 1720                 1725             


Asp Tyr  Glu His Val Thr Met  Leu Gln Glu Arg Phe  Arg Glu Phe 
    1730                 1735                 1740             


Ala Arg  Asp Thr Gly Asn Ile  Gly Gln Glu Arg Val  Asp Thr Val 
    1745                 1750                 1755             


Asn Asn  Met Ala Asp Glu Leu  Ile Asn Ser Gly His  Ser Asp Ala 
    1760                 1765                 1770             


Ala Thr  Ile Ala Glu Trp Lys  Asp Gly Leu Asn Glu  Ala Trp Ala 
    1775                 1780                 1785             


Asp Leu  Leu Glu Leu Ile Asp  Thr Arg Thr Gln Ile  Leu Ala Ala 
    1790                 1795                 1800             


Ser Tyr  Glu Leu His Lys Phe  Tyr His Asp Ala Lys  Glu Ile Phe 
    1805                 1810                 1815             


Gly Arg  Ile Gln Asp Lys His  Lys Lys Leu Pro Glu  Glu Leu Gly 
    1820                 1825                 1830             


Arg Asp  Gln Asn Thr Val Glu  Thr Leu Gln Arg Met  His Thr Thr 
    1835                 1840                 1845             


Phe Glu  His Asp Ile Gln Ala  Leu Gly Thr Gln Val  Arg Gln Leu 
    1850                 1855                 1860             


Gln Glu  Asp Ala Ala Arg Leu  Gln Ala Ala Tyr Ala  Gly Asp Lys 
    1865                 1870                 1875             


Ala Asp  Asp Ile Gln Lys Arg  Glu Asn Glu Val Leu  Glu Ala Trp 
    1880                 1885                 1890             


Lys Ser  Leu Leu Asp Ala Cys  Glu Gly Arg Arg Val  Arg Leu Val 
    1895                 1900                 1905             


Asp Thr  Gly Asp Lys Phe Arg  Phe Phe Ser Met Val  Arg Asp Leu 
    1910                 1915                 1920             


Met Leu  Trp Met Glu Asp Val  Ile Arg Gln Ile Glu  Ala Gln Glu 
    1925                 1930                 1935             


Lys Pro  Arg Asp Val Ser Ser  Val Glu Leu Leu Met  Asn Asn His 
    1940                 1945                 1950             


Gln Gly  Ile Lys Ala Glu Ile  Asp Ala Arg Asn Asp  Ser Phe Thr 
    1955                 1960                 1965             


Ala Cys  Ile Glu Leu Gly Lys  Ser Leu Leu Ala Arg  Lys His Tyr 
    1970                 1975                 1980             


Ala Ser  Glu Glu Ile Lys Glu  Lys Leu Leu Gln Leu  Thr Glu Lys 
    1985                 1990                 1995             


Arg Lys  Glu Met Ile Asp Lys  Trp Glu Asp Arg Trp  Glu Trp Leu 
    2000                 2005                 2010             


Arg Leu  Ile Leu Glu Val His  Gln Phe Ser Arg Asp  Ala Ser Val 
    2015                 2020                 2025             


Ala Glu  Ala Trp Leu Leu Gly  Gln Glu Pro Tyr Leu  Ser Ser Arg 
    2030                 2035                 2040             


Glu Ile  Gly Gln Ser Val Asp  Glu Val Glu Lys Leu  Ile Lys Arg 
    2045                 2050                 2055             


His Glu  Ala Phe Glu Lys Ser  Ala Ala Thr Trp Asp  Glu Arg Phe 
    2060                 2065                 2070             


Ser Ala  Leu Glu Arg Leu Thr  Thr Leu Glu Leu Leu  Glu Val Arg 
    2075                 2080                 2085             


Arg Gln  Gln Glu Glu Glu Glu  Arg Lys Arg Arg Pro  Pro Ser Pro 
    2090                 2095                 2100             


Asp Pro  Asn Thr Lys Val Ser  Glu Glu Ala Glu Ser  Gln Gln Trp 
    2105                 2110                 2115             


Asp Thr  Ser Lys Gly Asp Gln  Val Ser Gln Asn Gly  Leu Pro Ala 
    2120                 2125                 2130             


Glu Gln  Gly Ser Pro Arg Met  Ala Gly Thr Met Glu  Thr Ser Glu 
    2135                 2140                 2145             


Met Val  Asn Gly Ala Ala Glu  Gln Arg Thr Ser Ser  Lys Glu Ser 
    2150                 2155                 2160             


Ser Pro  Val Pro Ser Pro Thr  Leu Asp Arg Lys Ala  Lys Ser Ala 
    2165                 2170                 2175             


Leu Pro  Ala Gln Ser Ala Ala  Thr Leu Pro Ala Arg  Thr Leu Glu 
    2180                 2185                 2190             


Thr Pro  Ala Ala Gln Met Glu  Gly Phe Leu Asn Arg  Lys His Glu 
    2195                 2200                 2205             


Trp Glu  Ala His Asn Lys Lys  Ala Ser Ser Arg Ser  Trp His Asn 
    2210                 2215                 2220             


Val Tyr  Cys Val Ile Asn Asn  Gln Glu Met Gly Phe  Tyr Lys Asp 
    2225                 2230                 2235             


Ala Lys  Ser Ala Ala Ser Gly  Ile Pro Tyr His Ser  Glu Val Pro 
    2240                 2245                 2250             


Val Ser  Leu Lys Glu Ala Ile  Cys Glu Val Ala Leu  Asp Tyr Lys 
    2255                 2260                 2265             


Lys Lys  Lys His Val Phe Lys  Leu Arg Leu Ser Asp  Gly Asn Glu 
    2270                 2275                 2280             


Tyr Leu  Phe Gln Ala Lys Asp  Asp Glu Glu Met Asn  Thr Trp Ile 
    2285                 2290                 2295             


Gln Ala  Ile Ser Ser Ala Ile  Ser Ser Asp Lys His  Asp Thr Ser 
    2300                 2305                 2310             


Ala Ser  Thr Gln Ser Thr Pro  Ala Ser Ser Arg Ala  Gln Thr Leu 
    2315                 2320                 2325             


Pro Thr  Ser Val Val Thr Ile  Thr Ser Glu Ser Ser  Pro Gly Lys 
    2330                 2335                 2340             


Arg Glu  Lys Asp Lys Glu Lys  Asp Lys Glu Lys Arg  Phe Ser Leu 
    2345                 2350                 2355             


Phe Gly  Lys Lys Lys 
    2360                   





<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Val Ser Tyr Arg Ser Gln Thr Tyr 
1               5               


