                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> LONG-ACTING VEGF INHIBITORS FOR INTRAOCULAR NEOVASCULARIZATION

<130> 24978-0595

<140>
<141>

<150> 62/939,756
<151> 2019-11-25

<160> 18    

<170> PatentIn version 3.5

<210> 1
<211> 558
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210> 2
<211> 1674
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag      120

cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa      180

tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc      240

tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac      300

cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca      360

gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt      420

gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt      480

acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat      540

ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa      600

gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat      660

ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc      720

aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg      780

agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga      840

cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa      900

atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa      960

tctgttaaca cctcagtgca tatatatgat aaagacaaaa ctcacacatg cccaccgtgc     1020

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1080

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1140

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1200

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1260

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1320

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1380

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1440

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1500

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1560

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcac     1620

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           1674


<210> 3
<211> 459
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ile Phe Ile Ser Asp Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His 
        35                  40                  45              


Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro 
    50                  55                  60                  


Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro 
65                  70                  75                  80  


Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser 
                85                  90                  95      


Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val 
            100                 105                 110         


Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn 
        115                 120                 125             


Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val Lys Leu Leu 
    130                 135                 140                 


Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr Pro Leu Asn 
145                 150                 155                 160 


Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys Asn Lys Arg 
                165                 170                 175     


Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His Ala Asn Ile 
            180                 185                 190         


Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys Asp Lys Gly 
        195                 200                 205             


Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys Ser Val Asn 
    210                 215                 220                 


Thr Ser Val His Ile Tyr Asp Lys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 


<210> 4
<211> 1377
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggtat atttattagt gatacaggta gacctttcgt agagatgtac      120

agtgaaatcc ccgaaattat acacatgact gaaggaaggg agctcgtcat tccctgccgg      180

gttacgtcac ctaacatcac tgttacttta aaaaagtttc cacttgacac tttgatccct      240

gatggaaaac gcataatctg ggacagtaga aagggcttca tcatatcaaa tgcaacgtac      300

aaagaaatag ggcttctgac ctgtgaagca acagtcaatg ggcatttgta taagacaaac      360

tatctcacac atcgacaaac caatacaatc atagatgtcc aaataagcac accacgccca      420

gtcaaattac ttagaggcca tactcttgtc ctcaattgta ctgctaccac tcccttgaac      480

acgagagttc aaatgacctg gagttaccct gatgaaaaaa ataagagagc ttccgtaagg      540

cgacgaattg accaaagcaa ttcccatgcc aacatattct acagtgttct tactattgac      600

aaaatgcaga acaaagacaa aggactttat acttgtcgtg taaggagtgg accatcattc      660

aaatctgtta acacctcagt gcatatatat gataaagaca aaactcacac atgcccaccg      720

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      780

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      840

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      900

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      960

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1020

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1080

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1140

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1200

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1260

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1320

cacgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1377


<210> 5
<211> 659
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Val Gln Ile Ser 
                325                 330                 335     


Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn 
            340                 345                 350         


Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser 
        355                 360                 365             


Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp 
    370                 375                 380                 


Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp 
385                 390                 395                 400 


Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser 
                405                 410                 415     


Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys 
            420                 425                 430         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        435                 440                 445             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    450                 455                 460                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
465                 470                 475                 480 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                485                 490                 495     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            500                 505                 510         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        515                 520                 525             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    530                 535                 540                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
545                 550                 555                 560 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                565                 570                 575     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            580                 585                 590         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        595                 600                 605             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    610                 615                 620                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
625                 630                 635                 640 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                645                 650                 655     


Pro Gly Lys 
            


<210> 6
<211> 1977
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag      120

cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa      180

tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc      240

tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac      300

cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca      360

gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt      420

gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt      480

acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat      540

ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa      600

gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat      660

ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc      720

aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg      780

agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga      840

cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa      900

atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa      960

tctgttaaca cctcagtgca tatatatgat aaagcagtcc aaataagcac accacgccca     1020

gtcaaattac ttagaggcca tactcttgtc ctcaattgta ctgctaccac tcccttgaac     1080

acgagagttc aaatgacctg gagttaccct gatgaaaaaa ataagagagc ttccgtaagg     1140

cgacgaattg accaaagcaa ttcccatgcc aacatattct acagtgttct tactattgac     1200

aaaatgcaga acaaagacaa aggactttat acttgtcgtg taaggagtgg accatcattc     1260

aaatctgtta acacctcagt gcatatatat gataaagaca aaactcacac atgcccaccg     1320

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     1380

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     1440

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1500

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1560

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1620

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1680

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1740

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1800

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1860

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1920

cacgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1977


<210> 7
<211> 560
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ile Phe Ile Ser Asp Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His 
        35                  40                  45              


Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro 
    50                  55                  60                  


Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro 
65                  70                  75                  80  


Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser 
                85                  90                  95      


Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val 
            100                 105                 110         


Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn 
        115                 120                 125             


Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val Lys Leu Leu 
    130                 135                 140                 


Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr Pro Leu Asn 
145                 150                 155                 160 


Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys Asn Lys Arg 
                165                 170                 175     


Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His Ala Asn Ile 
            180                 185                 190         


Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys Asp Lys Gly 
        195                 200                 205             


Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys Ser Val Asn 
    210                 215                 220                 


Thr Ser Val His Ile Tyr Asp Lys Ala Val Gln Ile Ser Thr Pro Arg 
225                 230                 235                 240 


Pro Val Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala 
                245                 250                 255     


Thr Thr Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp 
            260                 265                 270         


Glu Lys Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn 
        275                 280                 285             


Ser His Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln 
    290                 295                 300                 


Asn Lys Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser 
305                 310                 315                 320 


Phe Lys Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210> 8
<211> 1680
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggtat atttattagt gatacaggta gacctttcgt agagatgtac      120

agtgaaatcc ccgaaattat acacatgact gaaggaaggg agctcgtcat tccctgccgg      180

gttacgtcac ctaacatcac tgttacttta aaaaagtttc cacttgacac tttgatccct      240

gatggaaaac gcataatctg ggacagtaga aagggcttca tcatatcaaa tgcaacgtac      300

aaagaaatag ggcttctgac ctgtgaagca acagtcaatg ggcatttgta taagacaaac      360

tatctcacac atcgacaaac caatacaatc atagatgtcc aaataagcac accacgccca      420

gtcaaattac ttagaggcca tactcttgtc ctcaattgta ctgctaccac tcccttgaac      480

acgagagttc aaatgacctg gagttaccct gatgaaaaaa ataagagagc ttccgtaagg      540

cgacgaattg accaaagcaa ttcccatgcc aacatattct acagtgttct tactattgac      600

aaaatgcaga acaaagacaa aggactttat acttgtcgtg taaggagtgg accatcattc      660

aaatctgtta acacctcagt gcatatatat gataaagcag tccaaataag cacaccacgc      720

ccagtcaaat tacttagagg ccatactctt gtcctcaatt gtactgctac cactcccttg      780

aacacgagag ttcaaatgac ctggagttac cctgatgaaa aaaataagag agcttccgta      840

aggcgacgaa ttgaccaaag caattcccat gccaacatat tctacagtgt tcttactatt      900

gacaaaatgc agaacaaaga caaaggactt tatacttgtc gtgtaaggag tggaccatca      960

ttcaaatctg ttaacacctc agtgcatata tatgataaag acaaaactca cacatgccca     1020

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1080

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1140

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1200

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1260

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1320

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1380

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1440

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1500

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1560

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1620

atgcacgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1680


<210> 9
<211> 655
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Asp Lys Thr His 
            420                 425                 430         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        435                 440                 445             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    450                 455                 460                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
465                 470                 475                 480 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                485                 490                 495     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            500                 505                 510         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        515                 520                 525             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    530                 535                 540                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
545                 550                 555                 560 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                565                 570                 575     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            580                 585                 590         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        595                 600                 605             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    610                 615                 620                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
625                 630                 635                 640 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650                 655 


<210> 10
<211> 1965
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggttc aaaattaaaa gatcctgaac tgagtttaaa aggcacccag      120

cacatcatgc aagcaggcca gacactgcat ctccaatgca ggggggaagc agcccataaa      180

tggtctttgc ctgaaatggt gagtaaggaa agcgaaaggc tgagcataac taaatctgcc      240

tgtggaagaa atggcaaaca attctgcagt actttaacct tgaacacagc tcaagcaaac      300

cacactggct tctacagctg caaatatcta gctgtaccta cttcaaagaa gaaggaaaca      360

gaatctgcaa tctatatatt tattagtgat acaggtagac ctttcgtaga gatgtacagt      420

gaaatccccg aaattataca catgactgaa ggaagggagc tcgtcattcc ctgccgggtt      480

acgtcaccta acatcactgt tactttaaaa aagtttccac ttgacacttt gatccctgat      540

ggaaaacgca taatctggga cagtagaaag ggcttcatca tatcaaatgc aacgtacaaa      600

gaaatagggc ttctgacctg tgaagcaaca gtcaatgggc atttgtataa gacaaactat      660

ctcacacatc gacaaaccaa tacaatcata gatgtccaaa taagcacacc acgcccagtc      720

aaattactta gaggccatac tcttgtcctc aattgtactg ctaccactcc cttgaacacg      780

agagttcaaa tgacctggag ttaccctgat gaaaaaaata agagagcttc cgtaaggcga      840

cgaattgacc aaagcaattc ccatgccaac atattctaca gtgttcttac tattgacaaa      900

atgcagaaca aagacaaagg actttatact tgtcgtgtaa ggagtggacc atcattcaaa      960

tctgttaaca cctcagtgca tatatatgat aaagcattca tcactgtgaa acatcgaaaa     1020

cagcaggtgc ttgaaaccgt agctggcaag cggtcttacc ggctctctat gaaagtgaag     1080

gcatttccct cgccggaagt tgtatggtta aaagatgggt tacctgcgac tgagaaatct     1140

gctcgctatt tgactcgtgg ctactcgtta attatcaagg acgtaactga agaggatgca     1200

gggaattata caatcttgct gagcataaaa cagtcaaatg tgtttaaaaa cctcactgcc     1260

actctaattg tcaatgtgaa acccgacaaa actcacacat gcccaccgtg cccagcacct     1320

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     1380

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1440

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1500

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1560

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1620

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1680

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1740

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1800

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1860

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca cgaggctctg     1920

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1965


<210> 11
<211> 556
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ile Phe Ile Ser Asp Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His 
        35                  40                  45              


Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro 
    50                  55                  60                  


Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro 
65                  70                  75                  80  


Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser 
                85                  90                  95      


Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val 
            100                 105                 110         


Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn 
        115                 120                 125             


Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val Lys Leu Leu 
    130                 135                 140                 


Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr Pro Leu Asn 
145                 150                 155                 160 


Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys Asn Lys Arg 
                165                 170                 175     


Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His Ala Asn Ile 
            180                 185                 190         


Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys Asp Lys Gly 
        195                 200                 205             


Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys Ser Val Asn 
    210                 215                 220                 


Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val Lys His Arg 
225                 230                 235                 240 


Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser Tyr Arg Leu 
                245                 250                 255     


Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val Trp Leu Lys 
            260                 265                 270         


Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu Thr Arg Gly 
        275                 280                 285             


Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala Gly Asn Tyr 
    290                 295                 300                 


Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys Asn Leu Thr 
305                 310                 315                 320 


Ala Thr Leu Ile Val Asn Val Lys Pro Asp Lys Thr His Thr Cys Pro 
                325                 330                 335     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            340                 345                 350         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        355                 360                 365             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    370                 375                 380                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
385                 390                 395                 400 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                405                 410                 415     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            420                 425                 430         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        435                 440                 445             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    450                 455                 460                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
465                 470                 475                 480 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                485                 490                 495     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            500                 505                 510         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        515                 520                 525             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    530                 535                 540                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555     


<210> 12
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggtat atttattagt gatacaggta gacctttcgt agagatgtac      120

agtgaaatcc ccgaaattat acacatgact gaaggaaggg agctcgtcat tccctgccgg      180

gttacgtcac ctaacatcac tgttacttta aaaaagtttc cacttgacac tttgatccct      240

gatggaaaac gcataatctg ggacagtaga aagggcttca tcatatcaaa tgcaacgtac      300

aaagaaatag ggcttctgac ctgtgaagca acagtcaatg ggcatttgta taagacaaac      360

tatctcacac atcgacaaac caatacaatc atagatgtcc aaataagcac accacgccca      420

gtcaaattac ttagaggcca tactcttgtc ctcaattgta ctgctaccac tcccttgaac      480

acgagagttc aaatgacctg gagttaccct gatgaaaaaa ataagagagc ttccgtaagg      540

cgacgaattg accaaagcaa ttcccatgcc aacatattct acagtgttct tactattgac      600

aaaatgcaga acaaagacaa aggactttat acttgtcgtg taaggagtgg accatcattc      660

aaatctgtta acacctcagt gcatatatat gataaagcat tcatcactgt gaaacatcga      720

aaacagcagg tgcttgaaac cgtagctggc aagcggtctt accggctctc tatgaaagtg      780

aaggcatttc cctcgccgga agttgtatgg ttaaaagatg ggttacctgc gactgagaaa      840

tctgctcgct atttgactcg tggctactcg ttaattatca aggacgtaac tgaagaggat      900

gcagggaatt atacaatctt gctgagcata aaacagtcaa atgtgtttaa aaacctcact      960

gccactctaa ttgtcaatgt gaaacccgac aaaactcaca catgcccacc gtgcccagca     1020

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc     1080

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct     1140

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     1200

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1260

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1320

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1380

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1440

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1500

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1560

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcacgaggct     1620

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1668


<210> 13
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ile Phe Ile Ser Asp Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His 
        35                  40                  45              


Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro 
    50                  55                  60                  


Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro 
65                  70                  75                  80  


Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser 
                85                  90                  95      


Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val 
            100                 105                 110         


Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn 
        115                 120                 125             


Thr Ile Ile Asp Val Phe Ile Thr Val Lys His Arg Lys Gln Gln Val 
    130                 135                 140                 


Leu Glu Thr Val Ala Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val 
145                 150                 155                 160 


Lys Ala Phe Pro Ser Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro 
                165                 170                 175     


Ala Thr Glu Lys Ser Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile 
            180                 185                 190         


Ile Lys Asp Val Thr Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu 
        195                 200                 205             


Ser Ile Lys Gln Ser Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile 
    210                 215                 220                 


Val Asn Val Lys Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210> 14
<211> 1368
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
atggtcagct actgggacac cggggtcctg ctgtgcgcgc tgctcagctg tctgcttctc       60

acaggatcta gttcaggtat atttattagt gatacaggta gacctttcgt agagatgtac      120

agtgaaatcc ccgaaattat acacatgact gaaggaaggg agctcgtcat tccctgccgg      180

gttacgtcac ctaacatcac tgttacttta aaaaagtttc cacttgacac tttgatccct      240

gatggaaaac gcataatctg ggacagtaga aagggcttca tcatatcaaa tgcaacgtac      300

aaagaaatag ggcttctgac ctgtgaagca acagtcaatg ggcatttgta taagacaaac      360

tatctcacac atcgacaaac caatacaatc atagatgtct tcatcactgt gaaacatcga      420

aaacagcagg tgcttgaaac cgtagctggc aagcggtctt accggctctc tatgaaagtg      480

aaggcatttc cctcgccgga agttgtatgg ttaaaagatg ggttacctgc gactgagaaa      540

tctgctcgct atttgactcg tggctactcg ttaattatca aggacgtaac tgaagaggat      600

gcagggaatt atacaatctt gctgagcata aaacagtcaa atgtgtttaa aaacctcact      660

gccactctaa ttgtcaatgt gaaacccgac aaaactcaca catgcccacc gtgcccagca      720

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcacgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1368


<210> 15
<211> 97
<212> PRT
<213> Homo sapiens

<400> 15
Pro Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln 
1               5                   10                  15      


Thr Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu 
            20                  25                  30          


Pro Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser 
        35                  40                  45              


Ala Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn 
    50                  55                  60                  


Thr Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala 
65                  70                  75                  80  


Val Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe 
                85                  90                  95      


Ile 
    


<210> 16
<211> 93
<212> PRT
<213> Homo sapiens

<400> 16
Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr 
1               5                   10                  15      


Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile 
            20                  25                  30          


Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly 
        35                  40                  45              


Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala 
    50                  55                  60                  


Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly 
65                  70                  75                  80  


His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr 
                85                  90              


<210> 17
<211> 100
<212> PRT
<213> Homo sapiens

<400> 17
Val Gln Ile Ser Thr Pro Arg Pro Val Lys Leu Leu Arg Gly His Thr 
1               5                   10                  15      


Leu Val Leu Asn Cys Thr Ala Thr Thr Pro Leu Asn Thr Arg Val Gln 
            20                  25                  30          


Met Thr Trp Ser Tyr Pro Asp Glu Lys Asn Lys Arg Ala Ser Val Arg 
        35                  40                  45              


Arg Arg Ile Asp Gln Ser Asn Ser His Ala Asn Ile Phe Tyr Ser Val 
    50                  55                  60                  


Leu Thr Ile Asp Lys Met Gln Asn Lys Asp Lys Gly Leu Tyr Thr Cys 
65                  70                  75                  80  


Arg Val Arg Ser Gly Pro Ser Phe Lys Ser Val Asn Thr Ser Val His 
                85                  90                  95      


Ile Tyr Asp Lys 
            100 


<210> 18
<211> 96
<212> PRT
<213> Homo sapiens

<400> 18
Phe Ile Thr Val Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala 
1               5                   10                  15      


Gly Lys Arg Ser Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser 
            20                  25                  30          


Pro Glu Val Val Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser 
        35                  40                  45              


Ala Arg Tyr Leu Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr 
    50                  55                  60                  


Glu Glu Asp Ala Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser 
65                  70                  75                  80  


Asn Val Phe Lys Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro 
                85                  90                  95      



