                         SEQUENCE LISTING

<110>  Glycostem Therapeutics B.V.
 
<120>  Method for obtaining CAR-NK cells

<130>  IP-10

<150>  N2024334
<151>  2019-11-28

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ala Leu Ser Asn His 
            20                  25                  30          


Gly Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Val Tyr Ser Gly Ser Thr Tyr Tyr Ala Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ser 
                85                  90                  95      


Ala His Gly Gly Glu Ser Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Arg Ala Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
    210                 215                 220                 


Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  2
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Leu Leu Thr Gln Ser Pro Val Ile 
    130                 135                 140                 


Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn Gly 
                165                 170                 175     


Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser 
        195                 200                 205             


Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  3
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of CAR cassete - CD8a leader sequence

<400>  3

Met Asp Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15      


Leu His Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of CAR casette - FseI-SbfI flanked stuffer fragment

<400>  4

Gly Arg Pro Ser Leu Ser Glu Ser Cys Arg Ala 
1               5                   10      


<210>  5
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of CAR cassette - IgD hinge region

<400>  5

Ala Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro 
1               5                   10                  15      


Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu 
            20                  25      


<210>  6
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of CAR cassette - Optimized IgG1 heavy chain Fc part, 
       optimized

<400>  6

Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Gly Arg 
1               5                   10                  15      


Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu 
            20                  25                  30          


Arg Glu Thr Lys Thr Pro Glu Ala Ala Ala Val Glu Pro Lys Ser Cys 
        35                  40                  45              


Asp Lys Thr His Thr Cys Pro Pro Cys Ala Ala Pro Pro Val Ala Gly 
    50                  55                  60                  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
65                  70                  75                  80  


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                85                  90                  95      


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            100                 105                 110         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        115                 120                 125             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    130                 135                 140                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
145                 150                 155                 160 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                165                 170                 175     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            180                 185                 190         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        195                 200                 205             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    210                 215                 220                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
225                 230                 235                 240 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                245                 250                 255     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            260                 265                 270         


Gly Lys 
        


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of CAR cassette - CD28 transmembrane domain

<400>  7

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  8
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of CAR cassette - CD28 co-activation domain

<400>  8

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  9
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of CAR cassette - OX40 co-activation domain

<400>  9

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of CAR cassette - CD3zeta activation domain

<400>  10

Arg Val Lys Phe Ser Arg Ser Ala Glu Pro Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  11
<211>  8619
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLenti CMV GFP Puro (658-5)

<400>  11
aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca       60

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa      120

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt      180

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca      240

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag      300

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc      360

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca      420

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt      480

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct      540

gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt      600

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga      660

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact      720

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc      780

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga      840

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt      900

agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga      960

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact     1020

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga     1080

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     1140

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     1200

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     1260

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta     1320

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     1380

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     1440

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     1500

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     1560

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     1620

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     1680

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     1740

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     1800

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt     1860

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga     1920

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta     1980

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa     2040

tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat     2100

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta     2160

cgccaagcgc gcaattaacc ctcactaaag ggaacaaaag ctggagctgc aagcttaatg     2220

tagtcttatg caatactctt gtagtcttgc aacatggtaa cgatgagtta gcaacatgcc     2280

ttacaaggag agaaaaagca ccgtgcatgc cgattggtgg aagtaaggtg gtacgatcgt     2340

gccttattag gaaggcaaca gacgggtctg acatggattg gacgaaccac tgaattgccg     2400

cattgcagag atattgtatt taagtgccta gctcgataca taaacgggtc tctctggtta     2460

gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa     2520

taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac     2580

tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg cgcccgaaca     2640

gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact cggcttgctg     2700

aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta     2760

gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta     2820

gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac     2880

atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa     2940

catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag     3000

aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag     3060

agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga     3120

ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat     3180

tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc     3240

accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg     3300

ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg     3360

gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct     3420

attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca     3480

agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc     3540

tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct     3600

ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac     3660

acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa     3720

gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg     3780

ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt     3840

tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag     3900

acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga agaaggtgga     3960

gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta tcggttaact     4020

tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata     4080

gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaattcaa aattttatcg     4140

ataagcttgg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc     4200

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg     4260

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca     4320

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc     4380

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt     4440

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata     4500

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt     4560

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca     4620

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg     4680

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgactcta     4740

gaggatccac cggtcgccac catggtgagc aagggcgagg agctgttcac cggggtggtg     4800

cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag     4860

ggcgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac caccggcaag     4920

ctgcccgtgc cctggcccac cctcgtgacc accctgacct acggcgtgca gtgcttcagc     4980

cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac     5040

gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg     5100

aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag     5160

gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa cgtctatatc     5220

atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag     5280

gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc     5340

gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac     5400

gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat cactctcggc     5460

atggacgagc tgtacaagta aagcggccgc gtcgacaatc aacctctgga ttacaaaatt     5520

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct     5580

gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg     5640

tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc     5700

gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt     5760

cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc     5820

gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg     5880

ttgtcgggga agctgacgtc ctttccatgg ctgctcgcct gtgttgccac ctggattctg     5940

cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc     6000

ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg     6060

atctcccttt gggccgcctc cccgcctgga attctaccgg gtaggggagg cgcttttccc     6120

aaggcagtct ggagcatgcg ctttagcagc cccgctgggc acttggcgct acacaagtgg     6180

cctctggcct cgcacacatt ccacatccac cggtaggcgc caaccggctc cgttctttgg     6240

tggccccttc gcgccacctt ctactcctcc cctagtcagg aagttccccc ccgccccgca     6300

gctcgcgtcg tgcaggacgt gacaaatgga agtagcacgt ctcactagtc tcgtgcagat     6360

ggacagcacc gctgagcaat ggaagcgggt aggcctttgg ggcagcggcc aatagcagct     6420

ttgctccttc gctttctggg ctcagaggct gggaaggggt gggtccgggg gcgggctcag     6480

gggcgggctc aggggcgggg cgggcgcccg aaggtcctcc ggaggcccgg cattctgcac     6540

gcttcaaaag cgcacgtctg ccgcgctgtt ctcctcttcc tcatctccgg gcctttcgac     6600

ctgcagccca agcttaccat gaccgagtac aagcccacgg tgcgcctcgc cacccgcgac     6660

gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc cgccacgcgc     6720

cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga actcttcctc     6780

acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc cgcggtggcg     6840

gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat cggcccgcgc     6900

atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg cctcctggcg     6960

ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggcgtctc gcccgaccac     7020

cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc cgagcgcgcc     7080

ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta cgagcggctc     7140

ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg gtgcatgacc     7200

cgcaagcccg gtgcctgacg cccgccccac gacccgcagc gcccgaccga aaggagcgca     7260

cgaccccatg catctcgagg gcccggtacc tttaagacca atgacttaca aggcagctgt     7320

agatcttagc cactttttaa aagaaaaggg gggactggaa gggctagctc actcccaacg     7380

aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg     7440

ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt     7500

gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc     7560

cttttagtca gtgtggaaaa tctctagcag tagtagttca tgtcatctta ttattcagta     7620

tttataactt gcaaagaaat gaatatcaga gagtgagagg aacttgttta ttgcagctta     7680

taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact     7740

gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggctctagct     7800

atcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     7860

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag     7920

ctattccaga agtagtgagg aggctttttt ggaggcctag ggacgtaccc aattcgccct     7980

atagtgagtc gtattacgcg cgctcactgg ccgtcgtttt acaacgtcgt gactgggaaa     8040

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     8100

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     8160

gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     8220

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     8280

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     8340

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     8400

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     8460

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     8520

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     8580

ttaacgcgaa ttttaacaaa atattaacgc ttacaattt                            8619


