                         SEQUENCE LISTING

<110>  REVELATIONS BIOTECH PRIVATE LIMITED
 
<120>  NUCLEIC ACIDS, VECTORS, HOST CELL AND METHODS FOR PRODUCTION OF 
       BETA-FRUCTOFURANOSIDASE FROM ASPERGILLUS NIGER

<130>  IP51142

<150>  IN201941048686
<151>  2019-11-27

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  654
<212>  PRT
<213>  Aspergillus niger

<400>  1

Met Lys Leu Thr Thr Thr Thr Leu Ala Leu Ala Thr Gly Ala Ala Ala 
1               5                   10                  15      


Ala Glu Ala Ser Tyr His Leu Asp Thr Thr Ala Pro Pro Pro Thr Asn 
            20                  25                  30          


Leu Ser Thr Leu Pro Asn Asn Thr Leu Phe His Val Trp Arg Pro Arg 
        35                  40                  45              


Ala His Ile Leu Pro Ala Glu Gly Gln Ile Gly Asp Pro Cys Ala His 
    50                  55                  60                  


Tyr Thr Asp Pro Ser Thr Gly Leu Phe His Val Gly Phe Leu His Asp 
65                  70                  75                  80  


Gly Asp Gly Ile Ala Gly Ala Thr Thr Ala Asn Leu Ala Thr Tyr Thr 
                85                  90                  95      


Asp Thr Ser Asp Asn Gly Ser Phe Leu Ile Gln Pro Gly Gly Lys Asn 
            100                 105                 110         


Asp Pro Val Ala Val Phe Asp Gly Ala Val Ile Pro Val Gly Val Asn 
        115                 120                 125             


Asn Thr Pro Thr Leu Leu Tyr Thr Ser Val Ser Phe Leu Pro Ile His 
    130                 135                 140                 


Trp Ser Ile Pro Tyr Thr Arg Gly Ser Glu Thr Gln Ser Leu Ala Val 
145                 150                 155                 160 


Ala Arg Asp Gly Gly Arg Arg Phe Asp Lys Leu Asp Gln Gly Pro Val 
                165                 170                 175     


Ile Ala Asp His Pro Phe Ala Val Asp Val Thr Ala Phe Arg Asp Pro 
            180                 185                 190         


Phe Val Phe Arg Ser Ala Lys Leu Asp Val Leu Leu Ser Leu Asp Glu 
        195                 200                 205             


Glu Val Ala Arg Asn Glu Thr Ala Val Gln Gln Ala Val Asp Gly Trp 
    210                 215                 220                 


Thr Glu Lys Asn Ala Pro Trp Tyr Val Ala Val Ser Gly Gly Val His 
225                 230                 235                 240 


Gly Val Gly Pro Ala Gln Phe Leu Tyr Arg Gln Asn Gly Gly Asn Ala 
                245                 250                 255     


Ser Glu Phe Gln Tyr Trp Glu Tyr Leu Gly Glu Trp Trp Gln Glu Ala 
            260                 265                 270         


Thr Asn Ser Ser Trp Gly Asp Glu Gly Thr Trp Ala Gly Arg Trp Gly 
        275                 280                 285             


Phe Asn Phe Glu Thr Gly Asn Val Leu Phe Leu Thr Glu Glu Gly His 
    290                 295                 300                 


Asp Pro Gln Thr Gly Glu Val Phe Val Thr Leu Gly Thr Glu Gly Ser 
305                 310                 315                 320 


Gly Leu Pro Ile Val Pro Gln Val Ser Ser Ile His Asp Met Leu Trp 
                325                 330                 335     


Ala Ala Gly Glu Val Gly Val Gly Ser Glu Gln Glu Gly Ala Lys Val 
            340                 345                 350         


Glu Phe Ser Pro Ser Met Ala Gly Phe Leu Asp Trp Gly Phe Ser Ala 
        355                 360                 365             


Tyr Ala Ala Ala Gly Lys Val Leu Pro Ala Ser Ser Ala Val Ser Lys 
    370                 375                 380                 


Thr Ser Gly Val Glu Val Asp Arg Tyr Val Ser Phe Val Trp Leu Thr 
385                 390                 395                 400 


Gly Asp Gln Tyr Glu Gln Ala Asp Gly Phe Pro Thr Ala Gln Gln Gly 
                405                 410                 415     


Trp Thr Gly Ser Leu Leu Leu Pro Arg Glu Leu Lys Val Gln Thr Val 
            420                 425                 430         


Glu Asn Val Val Asp Asn Glu Leu Val Arg Glu Glu Gly Val Ser Trp 
        435                 440                 445             


Val Val Gly Glu Ser Asp Asn Gln Thr Ala Arg Leu Arg Thr Leu Gly 
    450                 455                 460                 


Ile Thr Ile Ala Arg Glu Thr Lys Ala Ala Leu Leu Ala Asn Gly Ser 
465                 470                 475                 480 


Val Thr Ala Glu Glu Asp Arg Thr Leu Gln Thr Ala Ala Val Val Pro 
                485                 490                 495     


Phe Ala Gln Ser Pro Ser Ser Lys Phe Phe Val Leu Thr Ala Gln Leu 
            500                 505                 510         


Glu Phe Pro Ala Ser Ala Arg Ser Ser Pro Leu Gln Ser Gly Phe Glu 
        515                 520                 525             


Ile Leu Ala Ser Glu Leu Glu Arg Thr Ala Ile Tyr Tyr Gln Phe Ser 
    530                 535                 540                 


Asn Glu Ser Leu Val Val Asp Arg Ser Gln Thr Ser Ala Ala Ala Pro 
545                 550                 555                 560 


Thr Asn Pro Gly Leu Asp Ser Phe Thr Glu Ser Gly Lys Leu Arg Leu 
                565                 570                 575     


Phe Asp Val Ile Glu Asn Gly Gln Glu Gln Val Glu Thr Leu Asp Leu 
            580                 585                 590         


Thr Val Val Val Asp Asn Ala Val Val Glu Val Tyr Ala Asn Gly Arg 
        595                 600                 605             


Phe Ala Leu Ser Thr Trp Ala Arg Ser Trp Tyr Asp Asn Ser Thr Gln 
    610                 615                 620                 


Ile Arg Phe Phe His Asn Gly Glu Gly Glu Val Gln Phe Arg Asn Val 
625                 630                 635                 640 


Ser Val Ser Glu Gly Leu Tyr Asn Ala Trp Pro Glu Arg Asn 
                645                 650                 


<210>  2
<211>  1965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified nucleic acid sequence of the gene encoding 
       beta-fructofuranosidase

<400>  2
atgaaattga ctactactac tttggctttg gctactggtg ctgctgctgc tgaagcttct       60

taccatttgg atactactgc tccacctcca actaatttgt ctactttgcc taacaacact      120

ttgtttcatg tttggagacc aagagcccat attttgccag ctgaaggtca aattggagat      180

ccatgtgctc actacactga tccatctact ggtttgtttc atgttggttt cttgcacgat      240

ggagatggta ttgctggtgc tactactgct aatttggcta cttatactga tacttctgat      300

aacggttctt tcttgattca accaggtggt aaaaacgatc cagttgctgt tttcgatggt      360

gctgttattc ctgttggtgt taacaatact ccaactttgt tgtacacttc tgtttctttc      420

ttgcctattc attggtctat tccatatact agaggttctg aaactcaatc tttggctgtt      480

gctagagatg gtggtagaag attcgataaa ttggatcaag gtcctgttat tgctgatcac      540

ccatttgctg ttgatgttac tgctttcaga gatccttttg tttttagatc cgctaagttg      600

gatgttttgt tgtctttgga tgaagaggtt gctagaaatg agactgctgt tcaacaagct      660

gttgatggtt ggactgaaaa gaacgctcct tggtacgttg ctgtttctgg tggtgttcat      720

ggtgttggtc cagctcaatt tttgtataga caaaacggtg gtaatgcttc tgaattccaa      780

tactgggaat atttgggtga atggtggcaa gaagctacta attcttcttg gggagatgag      840

ggtacttggg ctggtagatg gggttttaac ttcgaaactg gtaacgtttt gtttttgact      900

gaagagggtc acgatccaca aactggagag gttttcgtta ctttgggtac tgaaggttct      960

ggtttgccta ttgttccaca agtttcttct attcacgata tgttgtgggc tgctggtgaa     1020

gttggtgttg gttctgaaca agagggtgct aaggttgaat tttctccttc tatggctggt     1080

ttcttggatt ggggtttctc tgcttacgct gctgctggta aagttttgcc agcttcttct     1140

gctgtttcta aaacttctgg tgttgaggtt gatagatacg tttcttttgt ttggttgact     1200

ggagatcaat atgaacaagc tgatggtttc cctactgctc aacaaggttg gactggttct     1260

ttgttgttgc caagagaatt gaaagttcaa actgttgaga acgttgttga taatgaattg     1320

gttagagaag agggtgtttc ttgggttgtt ggagagtctg ataatcaaac tgctagattg     1380

agaactttgg gtattactat tgctagagaa actaaggctg ctttgttggc taacggttct     1440

gttactgctg aagaggatag aactttgcaa actgctgctg ttgttccttt cgctcaatct     1500

ccatcttcta agtttttcgt tttgactgct caattggagt ttcctgcttc tgctagatcc     1560

tctccattgc aatctggttt cgaaattttg gcttctgaat tggagagaac tgctatctac     1620

taccaattct ctaacgagtc tttggttgtt gatagatccc aaacttctgc tgctgctcct     1680

actaacccag gtttggattc ttttactgag tctggtaaat tgagattgtt cgatgttatc     1740

gaaaacggtc aagaacaagt tgagactttg gatttgactg ttgttgttga taacgctgtt     1800

gttgaagttt acgctaatgg tagatttgct ttgtctactt gggctagatc ctggtacgat     1860

aactctactc aaatcagatt tttccacaat ggtgaaggag aggttcaatt cagaaacgtt     1920

tctgtttctg agggtttgta taacgcttgg ccagaaagaa attga                     1965


<210>  3
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Alpha-factor of S. cerevisiae (FAK)

<400>  3

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  4
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Alpha-factor full of S. cerevisiae (FAKS)

<400>  4

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Glu Ala Glu Ala 
                85                  


<210>  5
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Alpha factor_T of S. cerevisiae (AT)

<400>  5

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Leu Glu Lys Arg 
            20              


<210>  6
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Alpha-amylase of Aspergillus niger (AA)

<400>  6

Met Val Ala Trp Trp Ser Leu Phe Leu Tyr Gly Leu Gln Val Ala Ala 
1               5                   10                  15      


Pro Ala Leu Ala Leu Glu Lys Arg 
            20                  


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Glucoamylase of Aspergillus awamori (GA)

<400>  7

Met Ser Phe Arg Ser Leu Leu Ala Leu Ser Gly Leu Val Cys Ser Gly 
1               5                   10                  15      


Leu Ala Leu Glu Lys Arg 
            20          


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Inulinase of Kluyveromyces maxianus (IN)

<400>  8

Met Lys Leu Ala Tyr Ser Leu Leu Leu Pro Leu Ala Gly Val Ser Ala 
1               5                   10                  15      


Leu Glu Lys Arg 
            20  


<210>  9
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Invertase of S. cerevisiae (IV)

<400>  9

Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys 
1               5                   10                  15      


Ile Ser Ala Leu Glu Lys Arg 
            20              


<210>  10
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Killer protein of S. cerevisiae (KP)

<400>  10

Met Thr Lys Pro Thr Gln Val Leu Val Arg Ser Val Ser Ile Leu Phe 
1               5                   10                  15      


Phe Ile Thr Leu Leu His Leu Val Val Ala Leu Glu Lys Arg 
            20                  25                  30  


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Lysozyme of Gallus gallus (LZ)

<400>  11

Met Leu Gly Lys Asn Asp Pro Met Cys Leu Val Leu Val Leu Leu Gly 
1               5                   10                  15      


Leu Thr Ala Leu Leu Gly Ile Cys Gln Gly Leu Glu Lys Arg 
            20                  25                  30  


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Serum albumin of Homo sapiens (SA)

<400>  12

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Glu Lys Arg 
            20          


<210>  13
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha-factor (FAK) of S. cerevisiae fused to modified nucleic 
       acid of beta-fructofuranosidase gene

<400>  13
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga agagaatgaa attgactact actactttgg ctttggctac tggtgctgct      300

gctgctgaag cttcttacca tttggatact actgctccac ctccaactaa tttgtctact      360

ttgcctaaca acactttgtt tcatgtttgg agaccaagag cccatatttt gccagctgaa      420

ggtcaaattg gagatccatg tgctcactac actgatccat ctactggttt gtttcatgtt      480

ggtttcttgc acgatggaga tggtattgct ggtgctacta ctgctaattt ggctacttat      540

actgatactt ctgataacgg ttctttcttg attcaaccag gtggtaaaaa cgatccagtt      600

gctgttttcg atggtgctgt tattcctgtt ggtgttaaca atactccaac tttgttgtac      660

acttctgttt ctttcttgcc tattcattgg tctattccat atactagagg ttctgaaact      720

caatctttgg ctgttgctag agatggtggt agaagattcg ataaattgga tcaaggtcct      780

gttattgctg atcacccatt tgctgttgat gttactgctt tcagagatcc ttttgttttt      840

agatccgcta agttggatgt tttgttgtct ttggatgaag aggttgctag aaatgagact      900

gctgttcaac aagctgttga tggttggact gaaaagaacg ctccttggta cgttgctgtt      960

tctggtggtg ttcatggtgt tggtccagct caatttttgt atagacaaaa cggtggtaat     1020

gcttctgaat tccaatactg ggaatatttg ggtgaatggt ggcaagaagc tactaattct     1080

tcttggggag atgagggtac ttgggctggt agatggggtt ttaacttcga aactggtaac     1140

gttttgtttt tgactgaaga gggtcacgat ccacaaactg gagaggtttt cgttactttg     1200

ggtactgaag gttctggttt gcctattgtt ccacaagttt cttctattca cgatatgttg     1260

tgggctgctg gtgaagttgg tgttggttct gaacaagagg gtgctaaggt tgaattttct     1320

ccttctatgg ctggtttctt ggattggggt ttctctgctt acgctgctgc tggtaaagtt     1380

ttgccagctt cttctgctgt ttctaaaact tctggtgttg aggttgatag atacgtttct     1440

tttgtttggt tgactggaga tcaatatgaa caagctgatg gtttccctac tgctcaacaa     1500

ggttggactg gttctttgtt gttgccaaga gaattgaaag ttcaaactgt tgagaacgtt     1560

gttgataatg aattggttag agaagagggt gtttcttggg ttgttggaga gtctgataat     1620

caaactgcta gattgagaac tttgggtatt actattgcta gagaaactaa ggctgctttg     1680

ttggctaacg gttctgttac tgctgaagag gatagaactt tgcaaactgc tgctgttgtt     1740

cctttcgctc aatctccatc ttctaagttt ttcgttttga ctgctcaatt ggagtttcct     1800

gcttctgcta gatcctctcc attgcaatct ggtttcgaaa ttttggcttc tgaattggag     1860

agaactgcta tctactacca attctctaac gagtctttgg ttgttgatag atcccaaact     1920

tctgctgctg ctcctactaa cccaggtttg gattctttta ctgagtctgg taaattgaga     1980

ttgttcgatg ttatcgaaaa cggtcaagaa caagttgaga ctttggattt gactgttgtt     2040

gttgataacg ctgttgttga agtttacgct aatggtagat ttgctttgtc tacttgggct     2100

agatcctggt acgataactc tactcaaatc agatttttcc acaatggtga aggagaggtt     2160

caattcagaa acgtttctgt ttctgagggt ttgtataacg cttggccaga aagaaattga     2220


<210>  14
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha-factor full (FAKS) of S. cerevisiae fused to modified 
       nucleic acid of beta-fructofuranosidase gene

<400>  14
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

ccagtcaaca ctacaacaga agatgaaacg gcacaaattc cggctgaagc tgtcatcggt      120

tactcagatt tagaagggga tttcgatgtt gctgttttgc cattttccaa cagcacaaat      180

aacgggttat tgtttataaa tactactatt gccagcattg ctgctaaaga agaaggggta      240

tctctcgaga agagagaggc tgaagctatg aaattgacta ctactacttt ggctttggct      300

actggtgctg ctgctgctga agcttcttac catttggata ctactgctcc acctccaact      360

aatttgtcta ctttgcctaa caacactttg tttcatgttt ggagaccaag agcccatatt      420

ttgccagctg aaggtcaaat tggagatcca tgtgctcact acactgatcc atctactggt      480

ttgtttcatg ttggtttctt gcacgatgga gatggtattg ctggtgctac tactgctaat      540

ttggctactt atactgatac ttctgataac ggttctttct tgattcaacc aggtggtaaa      600

aacgatccag ttgctgtttt cgatggtgct gttattcctg ttggtgttaa caatactcca      660

actttgttgt acacttctgt ttctttcttg cctattcatt ggtctattcc atatactaga      720

ggttctgaaa ctcaatcttt ggctgttgct agagatggtg gtagaagatt cgataaattg      780

gatcaaggtc ctgttattgc tgatcaccca tttgctgttg atgttactgc tttcagagat      840

ccttttgttt ttagatccgc taagttggat gttttgttgt ctttggatga agaggttgct      900

agaaatgaga ctgctgttca acaagctgtt gatggttgga ctgaaaagaa cgctccttgg      960

tacgttgctg tttctggtgg tgttcatggt gttggtccag ctcaattttt gtatagacaa     1020

aacggtggta atgcttctga attccaatac tgggaatatt tgggtgaatg gtggcaagaa     1080

gctactaatt cttcttgggg agatgagggt acttgggctg gtagatgggg ttttaacttc     1140

gaaactggta acgttttgtt tttgactgaa gagggtcacg atccacaaac tggagaggtt     1200

ttcgttactt tgggtactga aggttctggt ttgcctattg ttccacaagt ttcttctatt     1260

cacgatatgt tgtgggctgc tggtgaagtt ggtgttggtt ctgaacaaga gggtgctaag     1320

gttgaatttt ctccttctat ggctggtttc ttggattggg gtttctctgc ttacgctgct     1380

gctggtaaag ttttgccagc ttcttctgct gtttctaaaa cttctggtgt tgaggttgat     1440

agatacgttt cttttgtttg gttgactgga gatcaatatg aacaagctga tggtttccct     1500

actgctcaac aaggttggac tggttctttg ttgttgccaa gagaattgaa agttcaaact     1560

gttgagaacg ttgttgataa tgaattggtt agagaagagg gtgtttcttg ggttgttgga     1620

gagtctgata atcaaactgc tagattgaga actttgggta ttactattgc tagagaaact     1680

aaggctgctt tgttggctaa cggttctgtt actgctgaag aggatagaac tttgcaaact     1740

gctgctgttg ttcctttcgc tcaatctcca tcttctaagt ttttcgtttt gactgctcaa     1800

ttggagtttc ctgcttctgc tagatcctct ccattgcaat ctggtttcga aattttggct     1860

tctgaattgg agagaactgc tatctactac caattctcta acgagtcttt ggttgttgat     1920

agatcccaaa cttctgctgc tgctcctact aacccaggtt tggattcttt tactgagtct     1980

ggtaaattga gattgttcga tgttatcgaa aacggtcaag aacaagttga gactttggat     2040

ttgactgttg ttgttgataa cgctgttgtt gaagtttacg ctaatggtag atttgctttg     2100

tctacttggg ctagatcctg gtacgataac tctactcaaa tcagattttt ccacaatggt     2160

gaaggagagg ttcaattcag aaacgtttct gtttctgagg gtttgtataa cgcttggcca     2220

gaaagaaatt ga                                                         2232


<210>  15
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha-factor_T (AT) of S. cerevisiae fused to modified nucleic 
       acid of beta-fructofuranosidase gene

<400>  15
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctctc       60

gagaagagaa tgaaattgac tactactact ttggctttgg ctactggtgc tgctgctgct      120

gaagcttctt accatttgga tactactgct ccacctccaa ctaatttgtc tactttgcct      180

aacaacactt tgtttcatgt ttggagacca agagcccata ttttgccagc tgaaggtcaa      240

attggagatc catgtgctca ctacactgat ccatctactg gtttgtttca tgttggtttc      300

ttgcacgatg gagatggtat tgctggtgct actactgcta atttggctac ttatactgat      360

acttctgata acggttcttt cttgattcaa ccaggtggta aaaacgatcc agttgctgtt      420

ttcgatggtg ctgttattcc tgttggtgtt aacaatactc caactttgtt gtacacttct      480

gtttctttct tgcctattca ttggtctatt ccatatacta gaggttctga aactcaatct      540

ttggctgttg ctagagatgg tggtagaaga ttcgataaat tggatcaagg tcctgttatt      600

gctgatcacc catttgctgt tgatgttact gctttcagag atccttttgt ttttagatcc      660

gctaagttgg atgttttgtt gtctttggat gaagaggttg ctagaaatga gactgctgtt      720

caacaagctg ttgatggttg gactgaaaag aacgctcctt ggtacgttgc tgtttctggt      780

ggtgttcatg gtgttggtcc agctcaattt ttgtatagac aaaacggtgg taatgcttct      840

gaattccaat actgggaata tttgggtgaa tggtggcaag aagctactaa ttcttcttgg      900

ggagatgagg gtacttgggc tggtagatgg ggttttaact tcgaaactgg taacgttttg      960

tttttgactg aagagggtca cgatccacaa actggagagg ttttcgttac tttgggtact     1020

gaaggttctg gtttgcctat tgttccacaa gtttcttcta ttcacgatat gttgtgggct     1080

gctggtgaag ttggtgttgg ttctgaacaa gagggtgcta aggttgaatt ttctccttct     1140

atggctggtt tcttggattg gggtttctct gcttacgctg ctgctggtaa agttttgcca     1200

gcttcttctg ctgtttctaa aacttctggt gttgaggttg atagatacgt ttcttttgtt     1260

tggttgactg gagatcaata tgaacaagct gatggtttcc ctactgctca acaaggttgg     1320

actggttctt tgttgttgcc aagagaattg aaagttcaaa ctgttgagaa cgttgttgat     1380

aatgaattgg ttagagaaga gggtgtttct tgggttgttg gagagtctga taatcaaact     1440

gctagattga gaactttggg tattactatt gctagagaaa ctaaggctgc tttgttggct     1500

aacggttctg ttactgctga agaggataga actttgcaaa ctgctgctgt tgttcctttc     1560

gctcaatctc catcttctaa gtttttcgtt ttgactgctc aattggagtt tcctgcttct     1620

gctagatcct ctccattgca atctggtttc gaaattttgg cttctgaatt ggagagaact     1680

gctatctact accaattctc taacgagtct ttggttgttg atagatccca aacttctgct     1740

gctgctccta ctaacccagg tttggattct tttactgagt ctggtaaatt gagattgttc     1800

gatgttatcg aaaacggtca agaacaagtt gagactttgg atttgactgt tgttgttgat     1860

aacgctgttg ttgaagttta cgctaatggt agatttgctt tgtctacttg ggctagatcc     1920

tggtacgata actctactca aatcagattt ttccacaatg gtgaaggaga ggttcaattc     1980

agaaacgttt ctgtttctga gggtttgtat aacgcttggc cagaaagaaa ttga           2034


<210>  16
<211>  2037
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha-amylase (AA) of Aspergillus niger fused to modified nucleic
       acid of beta-fructofuranosidase gene

<400>  16
atggttgctt ggtggagtct tttcctatac ggtctacagg tggcagctcc agcccttgcc       60

ctcgagaaga gaatgaaatt gactactact actttggctt tggctactgg tgctgctgct      120

gctgaagctt cttaccattt ggatactact gctccacctc caactaattt gtctactttg      180

cctaacaaca ctttgtttca tgtttggaga ccaagagccc atattttgcc agctgaaggt      240

caaattggag atccatgtgc tcactacact gatccatcta ctggtttgtt tcatgttggt      300

ttcttgcacg atggagatgg tattgctggt gctactactg ctaatttggc tacttatact      360

gatacttctg ataacggttc tttcttgatt caaccaggtg gtaaaaacga tccagttgct      420

gttttcgatg gtgctgttat tcctgttggt gttaacaata ctccaacttt gttgtacact      480

tctgtttctt tcttgcctat tcattggtct attccatata ctagaggttc tgaaactcaa      540

tctttggctg ttgctagaga tggtggtaga agattcgata aattggatca aggtcctgtt      600

attgctgatc acccatttgc tgttgatgtt actgctttca gagatccttt tgtttttaga      660

tccgctaagt tggatgtttt gttgtctttg gatgaagagg ttgctagaaa tgagactgct      720

gttcaacaag ctgttgatgg ttggactgaa aagaacgctc cttggtacgt tgctgtttct      780

ggtggtgttc atggtgttgg tccagctcaa tttttgtata gacaaaacgg tggtaatgct      840

tctgaattcc aatactggga atatttgggt gaatggtggc aagaagctac taattcttct      900

tggggagatg agggtacttg ggctggtaga tggggtttta acttcgaaac tggtaacgtt      960

ttgtttttga ctgaagaggg tcacgatcca caaactggag aggttttcgt tactttgggt     1020

actgaaggtt ctggtttgcc tattgttcca caagtttctt ctattcacga tatgttgtgg     1080

gctgctggtg aagttggtgt tggttctgaa caagagggtg ctaaggttga attttctcct     1140

tctatggctg gtttcttgga ttggggtttc tctgcttacg ctgctgctgg taaagttttg     1200

ccagcttctt ctgctgtttc taaaacttct ggtgttgagg ttgatagata cgtttctttt     1260

gtttggttga ctggagatca atatgaacaa gctgatggtt tccctactgc tcaacaaggt     1320

tggactggtt ctttgttgtt gccaagagaa ttgaaagttc aaactgttga gaacgttgtt     1380

gataatgaat tggttagaga agagggtgtt tcttgggttg ttggagagtc tgataatcaa     1440

actgctagat tgagaacttt gggtattact attgctagag aaactaaggc tgctttgttg     1500

gctaacggtt ctgttactgc tgaagaggat agaactttgc aaactgctgc tgttgttcct     1560

ttcgctcaat ctccatcttc taagtttttc gttttgactg ctcaattgga gtttcctgct     1620

tctgctagat cctctccatt gcaatctggt ttcgaaattt tggcttctga attggagaga     1680

actgctatct actaccaatt ctctaacgag tctttggttg ttgatagatc ccaaacttct     1740

gctgctgctc ctactaaccc aggtttggat tcttttactg agtctggtaa attgagattg     1800

ttcgatgtta tcgaaaacgg tcaagaacaa gttgagactt tggatttgac tgttgttgtt     1860

gataacgctg ttgttgaagt ttacgctaat ggtagatttg ctttgtctac ttgggctaga     1920

tcctggtacg ataactctac tcaaatcaga tttttccaca atggtgaagg agaggttcaa     1980

ttcagaaacg tttctgtttc tgagggtttg tataacgctt ggccagaaag aaattga        2037


<210>  17
<211>  2031
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Glucoamylase (GA) of Aspergillus awamori fused to modified 
       nucleic acid of beta-fructofuranosidase gene

<400>  17
atgtctttcc gatctctttt agccctatct ggacttgttt gttcaggttt ggctctcgag       60

aagagaatga aattgactac tactactttg gctttggcta ctggtgctgc tgctgctgaa      120

gcttcttacc atttggatac tactgctcca cctccaacta atttgtctac tttgcctaac      180

aacactttgt ttcatgtttg gagaccaaga gcccatattt tgccagctga aggtcaaatt      240

ggagatccat gtgctcacta cactgatcca tctactggtt tgtttcatgt tggtttcttg      300

cacgatggag atggtattgc tggtgctact actgctaatt tggctactta tactgatact      360

tctgataacg gttctttctt gattcaacca ggtggtaaaa acgatccagt tgctgttttc      420

gatggtgctg ttattcctgt tggtgttaac aatactccaa ctttgttgta cacttctgtt      480

tctttcttgc ctattcattg gtctattcca tatactagag gttctgaaac tcaatctttg      540

gctgttgcta gagatggtgg tagaagattc gataaattgg atcaaggtcc tgttattgct      600

gatcacccat ttgctgttga tgttactgct ttcagagatc cttttgtttt tagatccgct      660

aagttggatg ttttgttgtc tttggatgaa gaggttgcta gaaatgagac tgctgttcaa      720

caagctgttg atggttggac tgaaaagaac gctccttggt acgttgctgt ttctggtggt      780

gttcatggtg ttggtccagc tcaatttttg tatagacaaa acggtggtaa tgcttctgaa      840

ttccaatact gggaatattt gggtgaatgg tggcaagaag ctactaattc ttcttgggga      900

gatgagggta cttgggctgg tagatggggt tttaacttcg aaactggtaa cgttttgttt      960

ttgactgaag agggtcacga tccacaaact ggagaggttt tcgttacttt gggtactgaa     1020

ggttctggtt tgcctattgt tccacaagtt tcttctattc acgatatgtt gtgggctgct     1080

ggtgaagttg gtgttggttc tgaacaagag ggtgctaagg ttgaattttc tccttctatg     1140

gctggtttct tggattgggg tttctctgct tacgctgctg ctggtaaagt tttgccagct     1200

tcttctgctg tttctaaaac ttctggtgtt gaggttgata gatacgtttc ttttgtttgg     1260

ttgactggag atcaatatga acaagctgat ggtttcccta ctgctcaaca aggttggact     1320

ggttctttgt tgttgccaag agaattgaaa gttcaaactg ttgagaacgt tgttgataat     1380

gaattggtta gagaagaggg tgtttcttgg gttgttggag agtctgataa tcaaactgct     1440

agattgagaa ctttgggtat tactattgct agagaaacta aggctgcttt gttggctaac     1500

ggttctgtta ctgctgaaga ggatagaact ttgcaaactg ctgctgttgt tcctttcgct     1560

caatctccat cttctaagtt tttcgttttg actgctcaat tggagtttcc tgcttctgct     1620

agatcctctc cattgcaatc tggtttcgaa attttggctt ctgaattgga gagaactgct     1680

atctactacc aattctctaa cgagtctttg gttgttgata gatcccaaac ttctgctgct     1740

gctcctacta acccaggttt ggattctttt actgagtctg gtaaattgag attgttcgat     1800

gttatcgaaa acggtcaaga acaagttgag actttggatt tgactgttgt tgttgataac     1860

gctgttgttg aagtttacgc taatggtaga tttgctttgt ctacttgggc tagatcctgg     1920

tacgataact ctactcaaat cagatttttc cacaatggtg aaggagaggt tcaattcaga     1980

aacgtttctg tttctgaggg tttgtataac gcttggccag aaagaaattg a              2031


<210>  18
<211>  2025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inulinase (IN) of Kluyveromyces maxianus fused to modified 
       nucleic acid of beta-fructofuranosidase gene

<400>  18
atgaagttgg cttattctct tcttcttcct ctggccggag tgtctgccct cgagaagaga       60

atgaaattga ctactactac tttggctttg gctactggtg ctgctgctgc tgaagcttct      120

taccatttgg atactactgc tccacctcca actaatttgt ctactttgcc taacaacact      180

ttgtttcatg tttggagacc aagagcccat attttgccag ctgaaggtca aattggagat      240

ccatgtgctc actacactga tccatctact ggtttgtttc atgttggttt cttgcacgat      300

ggagatggta ttgctggtgc tactactgct aatttggcta cttatactga tacttctgat      360

aacggttctt tcttgattca accaggtggt aaaaacgatc cagttgctgt tttcgatggt      420

gctgttattc ctgttggtgt taacaatact ccaactttgt tgtacacttc tgtttctttc      480

ttgcctattc attggtctat tccatatact agaggttctg aaactcaatc tttggctgtt      540

gctagagatg gtggtagaag attcgataaa ttggatcaag gtcctgttat tgctgatcac      600

ccatttgctg ttgatgttac tgctttcaga gatccttttg tttttagatc cgctaagttg      660

gatgttttgt tgtctttgga tgaagaggtt gctagaaatg agactgctgt tcaacaagct      720

gttgatggtt ggactgaaaa gaacgctcct tggtacgttg ctgtttctgg tggtgttcat      780

ggtgttggtc cagctcaatt tttgtataga caaaacggtg gtaatgcttc tgaattccaa      840

tactgggaat atttgggtga atggtggcaa gaagctacta attcttcttg gggagatgag      900

ggtacttggg ctggtagatg gggttttaac ttcgaaactg gtaacgtttt gtttttgact      960

gaagagggtc acgatccaca aactggagag gttttcgtta ctttgggtac tgaaggttct     1020

ggtttgccta ttgttccaca agtttcttct attcacgata tgttgtgggc tgctggtgaa     1080

gttggtgttg gttctgaaca agagggtgct aaggttgaat tttctccttc tatggctggt     1140

ttcttggatt ggggtttctc tgcttacgct gctgctggta aagttttgcc agcttcttct     1200

gctgtttcta aaacttctgg tgttgaggtt gatagatacg tttcttttgt ttggttgact     1260

ggagatcaat atgaacaagc tgatggtttc cctactgctc aacaaggttg gactggttct     1320

ttgttgttgc caagagaatt gaaagttcaa actgttgaga acgttgttga taatgaattg     1380

gttagagaag agggtgtttc ttgggttgtt ggagagtctg ataatcaaac tgctagattg     1440

agaactttgg gtattactat tgctagagaa actaaggctg ctttgttggc taacggttct     1500

gttactgctg aagaggatag aactttgcaa actgctgctg ttgttccttt cgctcaatct     1560

ccatcttcta agtttttcgt tttgactgct caattggagt ttcctgcttc tgctagatcc     1620

tctccattgc aatctggttt cgaaattttg gcttctgaat tggagagaac tgctatctac     1680

taccaattct ctaacgagtc tttggttgtt gatagatccc aaacttctgc tgctgctcct     1740

actaacccag gtttggattc ttttactgag tctggtaaat tgagattgtt cgatgttatc     1800

gaaaacggtc aagaacaagt tgagactttg gatttgactg ttgttgttga taacgctgtt     1860

gttgaagttt acgctaatgg tagatttgct ttgtctactt gggctagatc ctggtacgat     1920

aactctactc aaatcagatt tttccacaat ggtgaaggag aggttcaatt cagaaacgtt     1980

tctgtttctg agggtttgta taacgcttgg ccagaaagaa attga                     2025


<210>  19
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Invertase (IV) of S.cerevisiae fused to modified nucleic acid of 
       beta-fructofuranosidase gene

<400>  19
atgcttttgc aggctttcct gttcttgctg gccggattcg ctgctaaaat ttccgctctc       60

gagaagagaa tgaaattgac tactactact ttggctttgg ctactggtgc tgctgctgct      120

gaagcttctt accatttgga tactactgct ccacctccaa ctaatttgtc tactttgcct      180

aacaacactt tgtttcatgt ttggagacca agagcccata ttttgccagc tgaaggtcaa      240

attggagatc catgtgctca ctacactgat ccatctactg gtttgtttca tgttggtttc      300

ttgcacgatg gagatggtat tgctggtgct actactgcta atttggctac ttatactgat      360

acttctgata acggttcttt cttgattcaa ccaggtggta aaaacgatcc agttgctgtt      420

ttcgatggtg ctgttattcc tgttggtgtt aacaatactc caactttgtt gtacacttct      480

gtttctttct tgcctattca ttggtctatt ccatatacta gaggttctga aactcaatct      540

ttggctgttg ctagagatgg tggtagaaga ttcgataaat tggatcaagg tcctgttatt      600

gctgatcacc catttgctgt tgatgttact gctttcagag atccttttgt ttttagatcc      660

gctaagttgg atgttttgtt gtctttggat gaagaggttg ctagaaatga gactgctgtt      720

caacaagctg ttgatggttg gactgaaaag aacgctcctt ggtacgttgc tgtttctggt      780

ggtgttcatg gtgttggtcc agctcaattt ttgtatagac aaaacggtgg taatgcttct      840

gaattccaat actgggaata tttgggtgaa tggtggcaag aagctactaa ttcttcttgg      900

ggagatgagg gtacttgggc tggtagatgg ggttttaact tcgaaactgg taacgttttg      960

tttttgactg aagagggtca cgatccacaa actggagagg ttttcgttac tttgggtact     1020

gaaggttctg gtttgcctat tgttccacaa gtttcttcta ttcacgatat gttgtgggct     1080

gctggtgaag ttggtgttgg ttctgaacaa gagggtgcta aggttgaatt ttctccttct     1140

atggctggtt tcttggattg gggtttctct gcttacgctg ctgctggtaa agttttgcca     1200

gcttcttctg ctgtttctaa aacttctggt gttgaggttg atagatacgt ttcttttgtt     1260

tggttgactg gagatcaata tgaacaagct gatggtttcc ctactgctca acaaggttgg     1320

actggttctt tgttgttgcc aagagaattg aaagttcaaa ctgttgagaa cgttgttgat     1380

aatgaattgg ttagagaaga gggtgtttct tgggttgttg gagagtctga taatcaaact     1440

gctagattga gaactttggg tattactatt gctagagaaa ctaaggctgc tttgttggct     1500

aacggttctg ttactgctga agaggataga actttgcaaa ctgctgctgt tgttcctttc     1560

gctcaatctc catcttctaa gtttttcgtt ttgactgctc aattggagtt tcctgcttct     1620

gctagatcct ctccattgca atctggtttc gaaattttgg cttctgaatt ggagagaact     1680

gctatctact accaattctc taacgagtct ttggttgttg atagatccca aacttctgct     1740

gctgctccta ctaacccagg tttggattct tttactgagt ctggtaaatt gagattgttc     1800

gatgttatcg aaaacggtca agaacaagtt gagactttgg atttgactgt tgttgttgat     1860

aacgctgttg ttgaagttta cgctaatggt agatttgctt tgtctacttg ggctagatcc     1920

tggtacgata actctactca aatcagattt ttccacaatg gtgaaggaga ggttcaattc     1980

agaaacgttt ctgtttctga gggtttgtat aacgcttggc cagaaagaaa ttga           2034


<210>  20
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Killer protein (KP) of S.cerevisiae fused to modified nucleic 
       acid of beta-fructofuranosidase gene

<400>  20
atgaccaaac caactcaagt tttggtgagg tctgtgtcaa tcctgttctt cattacttta       60

ctgcaccttg tagtcgcact cgagaagaga atgaaattga ctactactac tttggctttg      120

gctactggtg ctgctgctgc tgaagcttct taccatttgg atactactgc tccacctcca      180

actaatttgt ctactttgcc taacaacact ttgtttcatg tttggagacc aagagcccat      240

attttgccag ctgaaggtca aattggagat ccatgtgctc actacactga tccatctact      300

ggtttgtttc atgttggttt cttgcacgat ggagatggta ttgctggtgc tactactgct      360

aatttggcta cttatactga tacttctgat aacggttctt tcttgattca accaggtggt      420

aaaaacgatc cagttgctgt tttcgatggt gctgttattc ctgttggtgt taacaatact      480

ccaactttgt tgtacacttc tgtttctttc ttgcctattc attggtctat tccatatact      540

agaggttctg aaactcaatc tttggctgtt gctagagatg gtggtagaag attcgataaa      600

ttggatcaag gtcctgttat tgctgatcac ccatttgctg ttgatgttac tgctttcaga      660

gatccttttg tttttagatc cgctaagttg gatgttttgt tgtctttgga tgaagaggtt      720

gctagaaatg agactgctgt tcaacaagct gttgatggtt ggactgaaaa gaacgctcct      780

tggtacgttg ctgtttctgg tggtgttcat ggtgttggtc cagctcaatt tttgtataga      840

caaaacggtg gtaatgcttc tgaattccaa tactgggaat atttgggtga atggtggcaa      900

gaagctacta attcttcttg gggagatgag ggtacttggg ctggtagatg gggttttaac      960

ttcgaaactg gtaacgtttt gtttttgact gaagagggtc acgatccaca aactggagag     1020

gttttcgtta ctttgggtac tgaaggttct ggtttgccta ttgttccaca agtttcttct     1080

attcacgata tgttgtgggc tgctggtgaa gttggtgttg gttctgaaca agagggtgct     1140

aaggttgaat tttctccttc tatggctggt ttcttggatt ggggtttctc tgcttacgct     1200

gctgctggta aagttttgcc agcttcttct gctgtttcta aaacttctgg tgttgaggtt     1260

gatagatacg tttcttttgt ttggttgact ggagatcaat atgaacaagc tgatggtttc     1320

cctactgctc aacaaggttg gactggttct ttgttgttgc caagagaatt gaaagttcaa     1380

actgttgaga acgttgttga taatgaattg gttagagaag agggtgtttc ttgggttgtt     1440

ggagagtctg ataatcaaac tgctagattg agaactttgg gtattactat tgctagagaa     1500

actaaggctg ctttgttggc taacggttct gttactgctg aagaggatag aactttgcaa     1560

actgctgctg ttgttccttt cgctcaatct ccatcttcta agtttttcgt tttgactgct     1620

caattggagt ttcctgcttc tgctagatcc tctccattgc aatctggttt cgaaattttg     1680

gcttctgaat tggagagaac tgctatctac taccaattct ctaacgagtc tttggttgtt     1740

gatagatccc aaacttctgc tgctgctcct actaacccag gtttggattc ttttactgag     1800

tctggtaaat tgagattgtt cgatgttatc gaaaacggtc aagaacaagt tgagactttg     1860

gatttgactg ttgttgttga taacgctgtt gttgaagttt acgctaatgg tagatttgct     1920

ttgtctactt gggctagatc ctggtacgat aactctactc aaatcagatt tttccacaat     1980

ggtgaaggag aggttcaatt cagaaacgtt tctgtttctg agggtttgta taacgcttgg     2040

ccagaaagaa attga                                                      2055


<210>  21
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lysozyme (LZ) of Gallus gallus fused to modified nucleic acid of 
       beta-fructofuranosidase gene

<400>  21
atgctaggca aaaatgaccc tatgtgtttg gttctggttt tgcttggttt aaccgcttta       60

cttggtatct gtcaaggtct cgagaagaga atgaaattga ctactactac tttggctttg      120

gctactggtg ctgctgctgc tgaagcttct taccatttgg atactactgc tccacctcca      180

actaatttgt ctactttgcc taacaacact ttgtttcatg tttggagacc aagagcccat      240

attttgccag ctgaaggtca aattggagat ccatgtgctc actacactga tccatctact      300

ggtttgtttc atgttggttt cttgcacgat ggagatggta ttgctggtgc tactactgct      360

aatttggcta cttatactga tacttctgat aacggttctt tcttgattca accaggtggt      420

aaaaacgatc cagttgctgt tttcgatggt gctgttattc ctgttggtgt taacaatact      480

ccaactttgt tgtacacttc tgtttctttc ttgcctattc attggtctat tccatatact      540

agaggttctg aaactcaatc tttggctgtt gctagagatg gtggtagaag attcgataaa      600

ttggatcaag gtcctgttat tgctgatcac ccatttgctg ttgatgttac tgctttcaga      660

gatccttttg tttttagatc cgctaagttg gatgttttgt tgtctttgga tgaagaggtt      720

gctagaaatg agactgctgt tcaacaagct gttgatggtt ggactgaaaa gaacgctcct      780

tggtacgttg ctgtttctgg tggtgttcat ggtgttggtc cagctcaatt tttgtataga      840

caaaacggtg gtaatgcttc tgaattccaa tactgggaat atttgggtga atggtggcaa      900

gaagctacta attcttcttg gggagatgag ggtacttggg ctggtagatg gggttttaac      960

ttcgaaactg gtaacgtttt gtttttgact gaagagggtc acgatccaca aactggagag     1020

gttttcgtta ctttgggtac tgaaggttct ggtttgccta ttgttccaca agtttcttct     1080

attcacgata tgttgtgggc tgctggtgaa gttggtgttg gttctgaaca agagggtgct     1140

aaggttgaat tttctccttc tatggctggt ttcttggatt ggggtttctc tgcttacgct     1200

gctgctggta aagttttgcc agcttcttct gctgtttcta aaacttctgg tgttgaggtt     1260

gatagatacg tttcttttgt ttggttgact ggagatcaat atgaacaagc tgatggtttc     1320

cctactgctc aacaaggttg gactggttct ttgttgttgc caagagaatt gaaagttcaa     1380

actgttgaga acgttgttga taatgaattg gttagagaag agggtgtttc ttgggttgtt     1440

ggagagtctg ataatcaaac tgctagattg agaactttgg gtattactat tgctagagaa     1500

actaaggctg ctttgttggc taacggttct gttactgctg aagaggatag aactttgcaa     1560

actgctgctg ttgttccttt cgctcaatct ccatcttcta agtttttcgt tttgactgct     1620

caattggagt ttcctgcttc tgctagatcc tctccattgc aatctggttt cgaaattttg     1680

gcttctgaat tggagagaac tgctatctac taccaattct ctaacgagtc tttggttgtt     1740

gatagatccc aaacttctgc tgctgctcct actaacccag gtttggattc ttttactgag     1800

tctggtaaat tgagattgtt cgatgttatc gaaaacggtc aagaacaagt tgagactttg     1860

gatttgactg ttgttgttga taacgctgtt gttgaagttt acgctaatgg tagatttgct     1920

ttgtctactt gggctagatc ctggtacgat aactctactc aaatcagatt tttccacaat     1980

ggtgaaggag aggttcaatt cagaaacgtt tctgtttctg agggtttgta taacgcttgg     2040

ccagaaagaa attga                                                      2055


<210>  22
<211>  2031
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Serum albumin (SA) of Homo sapiens fused to modified nucleic acid
       of beta-fructofuranosidase gene

<400>  22
atgaagtggg taacatttat ttccctactg tttctttttt cttcagctta ctctctcgag       60

aagagaatga aattgactac tactactttg gctttggcta ctggtgctgc tgctgctgaa      120

gcttcttacc atttggatac tactgctcca cctccaacta atttgtctac tttgcctaac      180

aacactttgt ttcatgtttg gagaccaaga gcccatattt tgccagctga aggtcaaatt      240

ggagatccat gtgctcacta cactgatcca tctactggtt tgtttcatgt tggtttcttg      300

cacgatggag atggtattgc tggtgctact actgctaatt tggctactta tactgatact      360

tctgataacg gttctttctt gattcaacca ggtggtaaaa acgatccagt tgctgttttc      420

gatggtgctg ttattcctgt tggtgttaac aatactccaa ctttgttgta cacttctgtt      480

tctttcttgc ctattcattg gtctattcca tatactagag gttctgaaac tcaatctttg      540

gctgttgcta gagatggtgg tagaagattc gataaattgg atcaaggtcc tgttattgct      600

gatcacccat ttgctgttga tgttactgct ttcagagatc cttttgtttt tagatccgct      660

aagttggatg ttttgttgtc tttggatgaa gaggttgcta gaaatgagac tgctgttcaa      720

caagctgttg atggttggac tgaaaagaac gctccttggt acgttgctgt ttctggtggt      780

gttcatggtg ttggtccagc tcaatttttg tatagacaaa acggtggtaa tgcttctgaa      840

ttccaatact gggaatattt gggtgaatgg tggcaagaag ctactaattc ttcttgggga      900

gatgagggta cttgggctgg tagatggggt tttaacttcg aaactggtaa cgttttgttt      960

ttgactgaag agggtcacga tccacaaact ggagaggttt tcgttacttt gggtactgaa     1020

ggttctggtt tgcctattgt tccacaagtt tcttctattc acgatatgtt gtgggctgct     1080

ggtgaagttg gtgttggttc tgaacaagag ggtgctaagg ttgaattttc tccttctatg     1140

gctggtttct tggattgggg tttctctgct tacgctgctg ctggtaaagt tttgccagct     1200

tcttctgctg tttctaaaac ttctggtgtt gaggttgata gatacgtttc ttttgtttgg     1260

ttgactggag atcaatatga acaagctgat ggtttcccta ctgctcaaca aggttggact     1320

ggttctttgt tgttgccaag agaattgaaa gttcaaactg ttgagaacgt tgttgataat     1380

gaattggtta gagaagaggg tgtttcttgg gttgttggag agtctgataa tcaaactgct     1440

agattgagaa ctttgggtat tactattgct agagaaacta aggctgcttt gttggctaac     1500

ggttctgtta ctgctgaaga ggatagaact ttgcaaactg ctgctgttgt tcctttcgct     1560

caatctccat cttctaagtt tttcgttttg actgctcaat tggagtttcc tgcttctgct     1620

agatcctctc cattgcaatc tggtttcgaa attttggctt ctgaattgga gagaactgct     1680

atctactacc aattctctaa cgagtctttg gttgttgata gatcccaaac ttctgctgct     1740

gctcctacta acccaggttt ggattctttt actgagtctg gtaaattgag attgttcgat     1800

gttatcgaaa acggtcaaga acaagttgag actttggatt tgactgttgt tgttgataac     1860

gctgttgttg aagtttacgc taatggtaga tttgctttgt ctacttgggc tagatcctgg     1920

tacgataact ctactcaaat cagatttttc cacaatggtg aaggagaggt tcaattcaga     1980

aacgtttctg tttctgaggg tttgtataac gcttggccag aaagaaattg a              2031


<210>  23
<211>  1965
<212>  DNA
<213>  Aspergillus niger

<400>  23
atgaagctca ccactaccac cctggcgctc gccaccggcg cagcagcagc agaagcctca       60

taccacctgg acaccacggc cccgccgccg accaacctca gcaccctccc caacaacacc      120

ctcttccacg tgtggcggcc gcgcgcgcac atcctgcccg ccgagggcca gatcggcgac      180

ccctgcgcgc actacaccga cccatccacc ggcctcttcc acgtggggtt cctgcacgac      240

ggggacggca tcgcgggcgc caccacggcc aacctggcca cctacaccga tacctccgat      300

aacgggagct tcctgatcca gccgggcggg aagaacgacc ccgtcgccgt gttcgacggc      360

gccgtcatcc ccgtcggcgt caacaacacc cccaccttac tctacacctc cgtctccttc      420

ctgcccatcc actggtccat cccctacacc cgcggcagcg agacgcagtc gttggccgtc      480

gcgcgcgacg gcggccgccg cttcgacaag ctcgaccagg gccccgtcat cgccgaccac      540

cccttcgccg tcgacgtcac cgccttccgc gatccgtttg tcttccgcag tgccaagttg      600

gatgtgctgc tgtcgttgga tgaggaggtg gcgcggaatg agacggccgt gcagcaggcc      660

gtcgatggct ggaccgagaa gaacgccccc tggtatgtcg cggtctctgg cggggtgcac      720

ggcgtcgggc ccgcgcagtt cctctaccgc cagaacggcg ggaacgcttc cgagttccag      780

tactgggagt acctcgggga gtggtggcag gaggcgacca actccagctg gggcgacgag      840

ggcacctggg ccgggcgctg ggggttcaac ttcgagacgg ggaatgtgct cttcctcacc      900

gaggagggcc atgaccccca gacgggcgag gtgttcgtca ccctcggcac ggaggggtct      960

ggcctgccaa tcgtgccgca ggtctccagt atccacgata tgctgtgggc ggcgggtgag     1020

gtcggggtgg gcagtgagca ggagggtgcc aaggtcgagt tctccccctc catggccggg     1080

tttctggact gggggttcag cgcctacgct gcggcgggca aggtgctgcc ggccagctcg     1140

gcggtgtcga agaccagcgg cgtggaggtg gatcggtatg tctcgttcgt ctggttgacg     1200

ggcgaccagt acgagcaggc ggacgggttc cccacggccc agcaggggtg gacggggtcg     1260

ctgctgctgc cgcgcgagct gaaggtgcag acggtggaga acgtcgtcga caacgagctg     1320

gtgcgcgagg agggcgtgtc gtgggtggtg ggggagtcgg acaaccagac ggccaggctg     1380

cgcacgctgg ggatcacgat cgcccgggag accaaggcgg ccctgctggc caacggctcg     1440

gtgaccgcgg aggaggaccg cacgctgcag acggcggccg tcgtgccgtt cgcgcaatcg     1500

ccgagctcca agttcttcgt gctgacggcc cagctggagt tccccgcgag cgcgcgctcg     1560

tccccgctcc agtccgggtt cgaaatcctg gcgtcggagc tggagcgcac ggccatctac     1620

taccagttca gcaacgagtc gctggtcgtc gaccgcagcc agactagtgc ggcggcgccc     1680

acgaaccccg ggctggatag ctttactgag tccggcaagt tgcggttgtt cgacgtgatc     1740

gagaacggcc aggagcaggt cgagacgttg gatctcactg tcgtcgtgga taacgcggtt     1800

gtcgaggtgt atgccaacgg gcgctttgcg ttgagcacct gggcgagatc gtggtacgac     1860

aactccaccc agatccgctt cttccacaac ggcgagggcg aggtgcagtt caggaatgtc     1920

tccgtgtcgg aggggctcta taacgcctgg ccggagagaa attga                     1965


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved bioactive fragment of beta-fructofuranosidase of 
       Aspergillus niger (Position 57-62)

<400>  24

Gln Ile Gly Asp Pro Cys 
1               5       


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved bioactive fragment of beta-fructofuranosidase of 
       Aspergillus niger (Position 119-132)

<400>  25

Asp Gly Ala Val Ile Pro Val Gly Val Asn Asn Thr Pro Thr 
1               5                   10                  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved bioactive fragment of beta-fructofuranosidase of 
       Aspergillus niger (Position 320-330)

<400>  26

Ser Gly Leu Pro Ile Val Pro Gln Val Ser 
1               5                   10  


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conserved bioactive fragment of beta-fructofuranosidase of 
       Aspergillus niger (Position 401-416)

<400>  27

Gly Asp Gln Tyr Glu Gln Ala Asp Gly Phe Pro Thr Ala Gln Gln Gly 
1               5                   10                  15      


