                         SEQUENCE LISTING

<110>  NEWPEK S.A. DE C.V.
 
<120>  Phage-Resistant Microorganisms

<130>  524860WO

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic tfaD wildtype gene

<400>  1
attccagctg gcttcgtggc tgttttcaac agtgatgagt catcgtggca tctcgttgaa       60

gatcatcggg gtaaaacggt ttatgacgta gcgtcagggg acgcgttatt tatttctgaa      120

ctcggtccgt taccggaaaa tgttacctgg ttatcgccgg aaggggagtt tcagaagtgg      180

aacggtacag cctgggtgaa agatgcagaa gcagaaaaac tgttccggat tcgggaggcg      240

gaagaaacaa aaaacagcct gatgcaggta gccagtgagc atattgcgcc acttcaggat      300

gctgtagatc tggaaatcgc aacggaggaa gaaacctcat tgctggaagc ctggaaaaaa      360

tatcgggtgt tgctgaaccg tgttgataca tcaactgcac ctgatattga gtggcctacg      420

aaccctgtca gggagtaa                                                    438


<210>  2
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tfaD wildtype protein

<400>  2

Ile Pro Ala Gly Phe Val Ala Val Phe Asn Ser Asp Glu Ser Ser Trp 
1               5                   10                  15      


His Leu Val Glu Asp His Arg Gly Lys Thr Val Tyr Asp Val Ala Ser 
            20                  25                  30          


Gly Asp Ala Leu Phe Ile Ser Glu Leu Gly Pro Leu Pro Glu Asn Val 
        35                  40                  45              


Thr Trp Leu Ser Pro Glu Gly Glu Phe Gln Lys Trp Asn Gly Thr Ala 
    50                  55                  60                  


Trp Val Lys Asp Ala Glu Ala Glu Lys Leu Phe Arg Ile Arg Glu Ala 
65                  70                  75                  80  


Glu Glu Thr Lys Asn Ser Leu Met Gln Val Ala Ser Glu His Ile Ala 
                85                  90                  95      


Pro Leu Gln Asp Ala Val Asp Leu Glu Ile Ala Thr Glu Glu Glu Thr 
            100                 105                 110         


Ser Leu Leu Glu Ala Trp Lys Lys Tyr Arg Val Leu Leu Asn Arg Val 
        115                 120                 125             


Asp Thr Ser Thr Ala Pro Asp Ile Glu Trp Pro Thr Asn Pro Val Arg 
    130                 135                 140                 


Glu 
145 


<210>  3
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic tfaD mutated gene

<400>  3
attccagctg gcttcgtggc tgttttcaac agtgatgagt catcgtggca tctcgttgaa       60

gatcatcggg gtaaaacggt ttatgacgtg gcttccggcg acgcgttatt tatttctgaa      120

ctcggtccgt taccggaaaa tgttacctgg ttatcgccgg aaggggagtt tcagaagtgg      180

aacggcacag cctgggtgaa ggatacggaa gcagaaaaac tgttccggat ccgggaggcg      240

gaagaaacaa aaaacagcct gatgcaggta gccagtgagc atattgcgcc acttcaggat      300

gctgtagatc tggaaatcgc aacggaggaa gaaacctcat tgctggaagc ctggaaaaaa      360

tatcgggtgt tgctgaaccg tgttgataca tcaactgcac                            400


<210>  4
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tfaD mutated protein

<400>  4

Ile Pro Ala Gly Phe Val Ala Val Phe Asn Ser Asp Glu Ser Ser Trp 
1               5                   10                  15      


His Leu Val Glu Asp His Arg Gly Lys Thr Val Tyr Asp Val Ala Ser 
            20                  25                  30          


Gly Asp Ala Leu Phe Ile Ser Glu Leu Gly Pro Leu Pro Glu Asn Val 
        35                  40                  45              


Thr Trp Leu Ser Pro Glu Gly Glu Phe Gln Lys Trp Asn Gly Thr Ala 
    50                  55                  60                  


Trp Val Lys Asp Thr Glu Ala Glu Lys Leu Phe Arg Ile Arg Glu Ala 
65                  70                  75                  80  


Glu Glu Thr Lys Asn Ser Leu Met Gln Val Ala Ser Glu His Ile Ala 
                85                  90                  95      


Pro Leu Gln Asp Ala Val Asp Leu Glu Ile Ala Thr Glu Glu Glu Thr 
            100                 105                 110         


Ser Leu Leu Glu Ala Trp Lys Lys Tyr Arg Val Leu Leu Asn Arg Val 
        115                 120                 125             


Asp Thr Ser Thr Ala Pro Asp Ile Glu Trp Pro Thr Asn Pro Val Arg 
    130                 135                 140                 


Glu 
145 


<210>  5
<211>  3791
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic yejO wildtype gene

<400>  5
atgcatcaat ctggttctgt ttctctttgt cgttccgcaa tatctgttct ggtggctaca       60

gcgttatgga aggtgcgaac aagtccctga tatgagatca tgtttgtcat ctggagccat      120

agaacagggt tcatcatgag tcatcaactt accttcgccg acagtgaatt cagcagtaag      180

cgccgtcaga ccagaaaaga gattttcttg tcccgcatgg agcagattct gccatggcaa      240

aacatggtgg aagtcatcga gccgttttac cccaaggctg gtaatggccg gcgaccttat      300

ccgctggaaa ccatgctacg cattcactgc atgcagcatt ggtacaacct gagcgatggc      360

gcgatggaag atgctctgta cgaaatcgcc tccatgcgtc tgtttgcccg gttatccctg      420

gatagcgcct tgccggaccg caccaccatc atgaatttcc gccacctgct ggagcagcat      480

caactggccc gccaattgtt caagaccatc aatcgctggc tggccgaagc aggcgtcatg      540

atgactcaag gcaccttggt cgatgccacc atcattgagg cacccagctc gaccaagaac      600

aaagagcagc aacgcgatcc ggagatgcat cagaccaaga aaggcaatca gtggcacttt      660

ggcatgaagg cccacattgg tgtcgatgcc aagagtggcc tgacccacag cctggtcacc      720

accgcggcca acgagcatga cctcaatcag ctgggtaatc tgctgcatgg agaggagcaa      780

tttgtctcag ccgatgccgg ctaccaaggg gcgccacagc gcgaggagct ggccgaggtg      840

gatgtggact ggctgatcgc cgagcgcccc ggcaaggtaa gaaccttgaa acagcatcca      900

cgcaagaaca aaacggccat caacatcgaa tacatgaaag ccagcatccg ggccagggtg      960

gagcacccat ttcgcatcat caagcgacag ttcggcttcg tgaaagccag atacaagggg     1020

ttgctgaaaa acgataacca actggcgatg ttattcacgc tggccaacct gtttcgggcg     1080

gaccaaatga tacgtcagtg ggagagatct cactaaaaac tggggataac gccttaaatg     1140

gcgaagaaac ggtctaaata ggctgattca aggcatttac gggagaaaaa atcggctcaa     1200

acatgaagaa atgaaatgac tgagtcagcc gagaagaatt tccccgctta ttcgcacctt     1260

ccttatattc acccatagca ttggcatcaa ctgttgagta tggtgagaca gttgatggtg     1320

ttgtcctgga aaaagatatc cagctggttt atgggaccgc caataatacg aaaatcaatc     1380

ctggcggaga acagcatata aaagaatttg gtgtaagtaa taatactgaa attaacggag     1440

ggtatcagta cattgaaatg aatggcgccg cagaatactc agtattaaat gacggttatc     1500

aaattgttca aatgggtggc gcggcaaacc agactacgct caataatggt gtgctacagg     1560

tttatggcgc agcgaatgat accacgatta aaggcgggcg cttaatcgtt gaaaaagatg     1620

ggggggccgt ctttgtcgct atcgaaaagg gaggactact ggaggttaaa gaggggggat     1680

ttgcatttgc ggtagatcag aaagcaggcg gtgctattaa aacaaccacg cgggccatgg     1740

aggtattcgg aacaaaccgt ctcggtcagt tcgatatcaa gaatggtatt gctaataata     1800

tgttgttgga aaacggcgga agtttgcgag ttgaagaaaa tgacttcgct tataatacca     1860

ctgtagatag tggcggctta ctggaggtta tggatggcgg gactgtaact ggcgttgata     1920

aaaaagcagg cggaaaatta attgtctcaa cgaatgcgct ggaagtgagt ggtccaaaca     1980

gtaaaggcca atttagtata aaagatggtg tgtcaaaaaa ttatgaactg gatgatggtt     2040

ccgggctcat tgttatggag gacacgcagg ccattgatac tatccttgat aagcatgcca     2100

ctatgcaatc gctgggaaag gatactggta cgaaagtgca ggcaaatgcg gtatatgatc     2160

tcggtcgatc atatcagaat ggaagtatca cgtattcctc aaaagccatc tctgaaaata     2220

tggttatcaa caatggccgc gctaacgtct gggctggcac aatggttaac gtttcagtca     2280

gagggaatga tggcattctt gaggtcatga agccgcaaat aaattatgca cccgcaatgt     2340

tggtgggtaa ggtagtggtt tctgagggcg cttcttttag aacgcatggt gccgtggata     2400

ccagcaaagc ggacgtttcg ctcgaaaata gcgtatggac catcattgcc gatatcacta     2460

cgacgaacca aaacaccctc ctcaacttag ccaaccttgc gatgtctgac gcaaatgtga     2520

ttatgatgga tgagccagtg actcgttcat cagtgacggc aagtgcggaa aatttcatta     2580

cgttgaccac caataccctg tcgggaaacg gcaattttta tatgcgtacc gatatggcta     2640

atcatcagag cgatcagctc aacgtcaccg gtcaggcaac aggtgatttc aaaatattcg     2700

tgacggacac cggtgccagc ccggcagcag gagatagcct tacactggta acaacgggcg     2760

gcggtgatgc tgcatttacg ttgggcaatg ccggaggcgt tgttgatatc ggtacgtatg     2820

aatatacctt gctggataat ggcaaccata gctggagtct ggcagagaat cgcgcgcaaa     2880

ttaccccttc aaccactgat gtgctgaata tggcggccgc acaaccgctg gtatttgatg     2940

cagaactgga caccgtgcgt gagcgtcttg gtagcgtaaa aggcgttagt tacgatacgg     3000

cgatgtggag ttcggcaatt aacacccgca acaacgtgac cactgatgcg ggagctggtt     3060

ttgagcaaac attgacgggc ctgacgctcg gtatcgatag ccgtttctcc cgtgaagaaa     3120

gcagtacaat tcgcggcttg atctttggtt actctcattc tgatattggt tttgatcgcg     3180

gcggcaaagg taatatcgat agctataccc tgggggctta tgccggttgg gagcatcaga     3240

acggtgccta tgttgatggg gtggtgaaag ttgaccgttt tgccaacacc atccatggca     3300

agatgagtaa tggggcaaca gcgtttggcg attacaatag taacggcgcg ggtgctcatg     3360

ttgagagcgg gttccgttgg gttgacggat tgtggagtgt tagaccctat ctggccttta     3420

ccggctttac cacagatggt caggactaca cgttatcaaa cggcatgcgc gcggatgtgg     3480

gaaatacccg gatattacgc gctgaagcgg gaacggcggt aagctatcac atggacctgc     3540

aaaacggtac gacgctggaa ccctggctga aagcggccgt gcgtcaggaa tacgccgatt     3600

ctaaccaggt gaaagttaat gacgatggca aatttaataa tgatgtggct ggaaccagtg     3660

gcgtttatca ggctggtata aggtcatcgt ttaccccgac gttaagcggt catttgtcag     3720

tcagctatgg caatggcgca ggggtagaat cgccgtggaa tactcaggcg ggtgtggtct     3780

ggacgttctg a                                                          3791


<210>  6
<211>  1221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic yejO wildtype protein

<400>  6

Met His Gln Ser Gly Ser Val Ser Leu Cys Arg Ser Ala Ile Ser Val 
1               5                   10                  15      


Leu Val Ala Thr Ala Leu Trp Lys Val Arg Thr Ser Pro Tyr Glu Ile 
            20                  25                  30          


Met Phe Val Ile Trp Ser His Arg Thr Gly Phe Ile Met Ser His Gln 
        35                  40                  45              


Leu Thr Phe Ala Asp Ser Glu Phe Ser Ser Lys Arg Arg Gln Thr Arg 
    50                  55                  60                  


Lys Glu Ile Phe Leu Ser Arg Met Glu Gln Ile Leu Pro Trp Gln Asn 
65                  70                  75                  80  


Met Val Glu Val Ile Glu Pro Phe Tyr Pro Lys Ala Gly Asn Gly Arg 
                85                  90                  95      


Arg Pro Tyr Pro Leu Glu Thr Met Leu Arg Ile His Cys Met Gln His 
            100                 105                 110         


Trp Tyr Asn Leu Ser Asp Gly Ala Met Glu Asp Ala Leu Tyr Glu Ile 
        115                 120                 125             


Ala Ser Met Arg Leu Phe Ala Arg Leu Ser Leu Asp Ser Ala Leu Pro 
    130                 135                 140                 


Asp Arg Thr Thr Ile Met Asn Phe Arg His Leu Leu Glu Gln His Gln 
145                 150                 155                 160 


Leu Ala Arg Gln Leu Phe Lys Thr Ile Asn Arg Trp Leu Ala Glu Ala 
                165                 170                 175     


Gly Val Met Met Thr Gln Gly Thr Leu Val Asp Ala Thr Ile Ile Glu 
            180                 185                 190         


Ala Pro Ser Ser Thr Lys Asn Lys Glu Gln Gln Arg Asp Pro Glu Met 
        195                 200                 205             


His Gln Thr Lys Lys Gly Asn Gln Trp His Phe Gly Met Lys Ala His 
    210                 215                 220                 


Ile Gly Val Asp Ala Lys Ser Gly Leu Thr His Ser Leu Val Thr Thr 
225                 230                 235                 240 


Ala Ala Asn Glu His Asp Leu Asn Gln Leu Gly Asn Leu Leu His Gly 
                245                 250                 255     


Glu Glu Gln Phe Val Ser Ala Asp Ala Gly Tyr Gln Gly Ala Pro Gln 
            260                 265                 270         


Arg Glu Glu Leu Ala Glu Val Asp Val Asp Trp Leu Ile Ala Glu Arg 
        275                 280                 285             


Pro Gly Lys Val Arg Thr Leu Lys Gln His Pro Arg Lys Asn Lys Thr 
    290                 295                 300                 


Ala Ile Asn Ile Glu Tyr Met Lys Ala Ser Ile Arg Ala Arg Val Glu 
305                 310                 315                 320 


His Pro Phe Arg Ile Ile Lys Arg Gln Phe Gly Phe Val Lys Ala Arg 
                325                 330                 335     


Tyr Lys Gly Leu Leu Lys Asn Asp Asn Gln Leu Ala Met Leu Phe Thr 
            340                 345                 350         


Leu Ala Asn Leu Phe Arg Ala Asp Gln Met Ile Arg Gln Trp Glu Arg 
        355                 360                 365             


Ser His Lys Leu Gly Ile Thr Pro Met Ala Lys Lys Arg Ser Lys Ala 
    370                 375                 380                 


Asp Ser Arg His Leu Arg Glu Lys Lys Ser Ala Gln Thr Arg Asn Glu 
385                 390                 395                 400 


Met Thr Glu Ser Ala Glu Lys Asn Phe Pro Ala Tyr Ser His Leu Pro 
                405                 410                 415     


Tyr Ile His Pro His Trp His Gln Leu Leu Ser Met Val Arg Gln Leu 
            420                 425                 430         


Met Val Leu Ser Trp Lys Lys Ile Ser Ser Trp Phe Met Gly Pro Pro 
        435                 440                 445             


Ile Ile Arg Lys Ser Ile Leu Ala Glu Asn Ser Ile Lys Asn Leu Val 
    450                 455                 460                 


Val Ile Ile Leu Lys Leu Thr Glu Gly Ile Ser Thr Leu Lys Met Ala 
465                 470                 475                 480 


Pro Gln Asn Thr Gln Tyr Met Thr Val Ile Lys Leu Phe Lys Trp Val 
                485                 490                 495     


Ala Arg Gln Thr Arg Leu Arg Ser Ile Met Val Cys Tyr Arg Phe Met 
            500                 505                 510         


Ala Gln Arg Met Ile Pro Arg Leu Lys Ala Gly Ala Ser Leu Lys Lys 
        515                 520                 525             


Met Gly Gly Pro Ser Leu Ser Leu Ser Lys Arg Glu Asp Tyr Trp Arg 
    530                 535                 540                 


Leu Lys Arg Gly Asp Leu His Leu Arg Ile Arg Lys Gln Ala Val Leu 
545                 550                 555                 560 


Leu Lys Gln Pro Arg Gly Pro Trp Arg Tyr Ser Glu Gln Thr Val Ser 
                565                 570                 575     


Val Ser Ser Ile Ser Arg Met Val Leu Leu Ile Ile Cys Cys Trp Lys 
            580                 585                 590         


Thr Ala Glu Val Cys Glu Leu Lys Lys Met Thr Ser Leu Ile Ile Pro 
        595                 600                 605             


Leu Ile Val Ala Ala Tyr Trp Arg Leu Trp Met Ala Gly Leu Leu Ala 
    610                 615                 620                 


Leu Ile Lys Lys Gln Ala Glu Asn Leu Ser Gln Arg Met Arg Trp Lys 
625                 630                 635                 640 


Val Val Gln Thr Val Lys Ala Asn Leu Val Lys Met Val Cys Gln Lys 
                645                 650                 655     


Ile Met Asn Trp Met Met Val Pro Gly Ser Leu Leu Trp Arg Thr Arg 
            660                 665                 670         


Arg Pro Leu Ile Leu Ser Leu Ile Ser Met Pro Leu Cys Asn Arg Trp 
        675                 680                 685             


Glu Arg Ile Leu Val Arg Lys Cys Arg Gln Met Arg Tyr Met Ile Ser 
    690                 695                 700                 


Val Asp His Ile Arg Met Glu Val Ser Arg Ile Pro Gln Lys Pro Ser 
705                 710                 715                 720 


Leu Lys Ile Trp Leu Ser Thr Met Ala Ala Leu Thr Ser Gly Leu Ala 
                725                 730                 735     


Gln Trp Leu Thr Phe Gln Ser Glu Gly Met Met Ala Phe Leu Arg Ser 
            740                 745                 750         


Ser Arg Lys Ile Met His Pro Gln Cys Trp Trp Val Arg Trp Phe Leu 
        755                 760                 765             


Arg Ala Leu Leu Leu Glu Arg Met Val Pro Trp Ile Pro Ala Lys Arg 
    770                 775                 780                 


Thr Phe Arg Ser Lys Ile Ala Tyr Gly Pro Ser Leu Pro Ile Ser Leu 
785                 790                 795                 800 


Arg Arg Thr Lys Thr Pro Ser Ser Thr Pro Thr Leu Arg Cys Leu Thr 
                805                 810                 815     


Gln Met Leu Trp Met Ser Gln Leu Val His Gln Arg Gln Val Arg Lys 
            820                 825                 830         


Ile Ser Leu Arg Pro Pro Ile Pro Cys Arg Glu Thr Ala Ile Phe Ile 
        835                 840                 845             


Cys Val Pro Ile Trp Leu Ile Ile Arg Ala Ile Ser Ser Thr Ser Pro 
    850                 855                 860                 


Val Arg Gln Gln Val Ile Ser Lys Tyr Ser Arg Thr Pro Val Pro Ala 
865                 870                 875                 880 


Arg Gln Gln Glu Ile Ala Leu His Trp Gln Arg Ala Ala Val Met Leu 
                885                 890                 895     


His Leu Arg Trp Ala Met Pro Glu Ala Leu Leu Ile Ser Val Arg Met 
            900                 905                 910         


Asn Ile Pro Cys Trp Ile Met Ala Thr Ile Ala Gly Val Trp Gln Arg 
        915                 920                 925             


Ile Ala Arg Lys Leu Pro Leu Gln Pro Leu Met Cys Ile Trp Arg Pro 
    930                 935                 940                 


His Asn Arg Trp Tyr Leu Met Gln Asn Trp Thr Pro Cys Val Ser Val 
945                 950                 955                 960 


Leu Val Ala Lys Ala Leu Val Thr Ile Arg Arg Cys Gly Val Arg Gln 
                965                 970                 975     


Leu Thr Pro Ala Thr Thr Pro Leu Met Arg Glu Leu Val Leu Ser Lys 
            980                 985                 990         


His Arg Ala Arg Ser Val Ser Ile  Ala Val Ser Pro Val  Lys Lys Ala 
        995                 1000                 1005             


Val Gln  Phe Ala Ala Ser Leu  Val Thr Leu Ile Leu  Ile Leu Val 
    1010                 1015                 1020             


Leu Ile  Ala Ala Ala Lys Val  Ile Ser Ile Ala Ile  Pro Trp Gly 
    1025                 1030                 1035             


Leu Met  Pro Val Gly Ser Ile  Arg Thr Val Pro Met  Leu Met Gly 
    1040                 1045                 1050             


Trp Lys  Leu Thr Val Leu Pro  Thr Pro Ser Met Ala  Arg Val Met 
    1055                 1060                 1065             


Gly Gln  Gln Arg Leu Ala Ile  Thr Ile Val Thr Ala  Arg Val Leu 
    1070                 1075                 1080             


Met Leu  Arg Ala Gly Ser Val  Gly Leu Thr Asp Cys  Gly Val Leu 
    1085                 1090                 1095             


Asp Pro  Ile Trp Pro Leu Pro  Ala Leu Pro Gln Met  Val Arg Thr 
    1100                 1105                 1110             


Thr Arg  Tyr Gln Thr Ala Cys  Ala Arg Met Trp Glu  Ile Pro Gly 
    1115                 1120                 1125             


Tyr Tyr  Ala Leu Lys Arg Glu  Arg Arg Ala Ile Thr  Trp Thr Cys 
    1130                 1135                 1140             


Lys Thr  Val Arg Arg Trp Asn  Pro Gly Lys Arg Pro  Cys Val Arg 
    1145                 1150                 1155             


Asn Thr  Pro Ile Leu Thr Arg  Lys Leu Met Thr Met  Ala Asn Leu 
    1160                 1165                 1170             


Ile Met  Met Trp Leu Glu Pro  Val Ala Phe Ile Arg  Leu Val Gly 
    1175                 1180                 1185             


His Arg  Leu Pro Arg Arg Ala  Val Ile Cys Gln Ser  Ala Met Ala 
    1190                 1195                 1200             


Met Ala  Gln Gly Asn Arg Arg  Gly Ile Leu Arg Arg  Val Trp Ser 
    1205                 1210                 1215             


Gly Arg  Ser 
    1220     


<210>  7
<211>  3791
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic yejO mutated gene

<400>  7
atgcatcaat ctggttctgt ttctctttgt cgttccgcaa tatctgttct ggtggctaca       60

gcgttaagga aggtgcgaac aagtccctga tatgagatca tgtttgtcat ctggagccat      120

agaacagggt tcatcatgag tcatcaactt accttcgccg acagtgaatt cagcagtaag      180

cgccgtcaga ccagaaaaga gattttcttg tcccgcatgg agcagattct gccatggcaa      240

aacatggtgg aagtcatcga gccgttttac cccaaggctg gtaatggccg gcgaccttat      300

ccgctggaaa ccatgctacg cattcactgc atgcagcatt ggtacaacct gagcgatggc      360

gcgatggaag atgctctgta cgaaatcgcc tccatgcgtc tgtttgcccg gttatccctg      420

gatagcgcct tgccggaccg caccaccatc atgaatttcc gccacctgct ggagcagcat      480

caactggccc gccaattgtt caagaccatc aatcgctggc tggccgaagc aggcgtcatg      540

atgactcaag gcaccttggt cgatgccacc atcattgagg cacccagctc gaccaagaac      600

aaagagcagc aacgcgatcc ggagatgcat cagaccaaga aaggcaatca gtggcacttt      660

ggcatgaagg cccacattgg tgtcgatgcc aagagtggcc tgacccacag cctggtcacc      720

accgcggcca acgagcatga cctcaatcag ctgggtaatc tgctgcatgg agaggagcaa      780

tttgtctcag ccgatgccgg ctaccaaggg gcgccacagc gcgaggagct ggccgaggtg      840

gatgtggact ggctgatcgc cgagcgcccc ggcaaggtaa gaaccttgaa acagcatcca      900

cgcaagaaca aaacggccat caacatcgaa tacatgaaag ccagcatccg ggccagggtg      960

gagcacccat ttcgcatcat caagcgacag ttcggcttcg tgaaagccag atacaagggg     1020

ttgctgaaaa acgataacca actggcgatg ttattcacgc tggccaacct gtttcgggcg     1080

gaccaaatga tacgtcagtg ggagagatct cactaaaaac tggggataac gccttaaatg     1140

gcgaagaaac ggtctaaata ggctgattca aggcatttac gggagaaaaa atcggctcaa     1200

acatgaagaa atgaaatgac tgagtcagcc gagaagaatt tccccgctta ttcgcacctt     1260

ccttatattc acccatagca ttggcatcaa ctgttgagta tggtgagaca gttgatggtg     1320

ttgtcctgga aaaagatatc cagctggttt atgggaccgc caataatacg aaaatcaatc     1380

ctggcggaga acagcatata aaagaatttg gtgtaagtaa taatactgaa attaacggag     1440

ggtatcagta cattgaaatg aatggcgccg cagaatactc agtattaaat gacggttatc     1500

aaattgttca aatgggtggc gcggcaaacc agactacgct caataatggt gtgctacagg     1560

tttatggcgc agcgaatgat accacgatta aaggcgggcg cttaatcgtt gaaaaagatg     1620

ggggggccgt ctttgtcgct atcgaaaagg gaggactact ggaggttaaa gaggggggat     1680

ttgcatttgc ggtagatcag aaagcaggcg gtgctattaa aacaaccacg cgggccatgg     1740

aggtattcgg aacaaaccgt ctcggtcagt tcgatatcaa gaatggtatt gctaataata     1800

tgttgttgga aaacggcgga agtttgcgag ttgaagaaaa tgacttcgct tataatacca     1860

ctgtagatag tggcggctta ctggaggtta tggatggcgg gactgtaact ggcgttgata     1920

aaaaagcagg cggaaaatta attgtctcaa cgaatgcgct ggaagtgagt ggtccaaaca     1980

gtaaaggcca atttagtata aaagatggtg tgtcaaaaaa ttatgaactg gatgatggtt     2040

ccgggctcat tgttatggag gacacgcagg ccattgatac tatccttgat aagcatgcca     2100

ctatgcaatc gctgggaaag gatactggta cgaaagtgca ggcaaatgcg gtatatgatc     2160

tcggtcgatc atatcagaat ggaagtatca cgtattcctc aaaagccatc tctgaaaata     2220

tggttatcaa caatggccgc gctaacgtct gggctggcac aatggttaac gtttcagtca     2280

gagggaatga tggcattctt gaggtcatga agccgcaaat aaattatgca cccgcaatgt     2340

tggtgggtaa ggtagtggtt tctgagggcg cttcttttag aacgcatggt gccgtggata     2400

ccagcaaagc ggacgtttcg ctcgaaaata gcgtatggac catcattgcc gatatcacta     2460

cgacgaacca aaacaccctc ctcaacttag ccaaccttgc gatgtctgac gcaaatgtga     2520

ttatgatgga tgagccagtg actcgttcat cagtgacggc aagtgcggaa aatttcatta     2580

cgttgaccac caataccctg tcgggaaacg gcaattttta tatgcgtacc gatatggcta     2640

atcatcagag cgatcagctc aacgtcaccg gtcaggcaac aggtgatttc aaaatattcg     2700

tgacggacac cggtgccagc ccggcagcag gagatagcct tacactggta acaacgggcg     2760

gcggtgatgc tgcatttacg ttgggcaatg ccggaggcgt tgttgatatc ggtacgtatg     2820

aatatacctt gctggataat ggcaaccata gctggagtct ggcagagaat cgcgcgcaaa     2880

ttaccccttc aaccactgat gtgctgaata tggcggccgc acaaccgctg gtatttgatg     2940

cagaactgga caccgtgcgt gagcgtcttg gtagcgtaaa aggcgttagt tacgatacgg     3000

cgatgtggag ttcggcaatt aacacccgca acaacgtgac cactgatgcg ggagctggtt     3060

ttgagcaaac attgacgggc ctgacgctcg gtatcgatag ccgtttctcc cgtgaagaaa     3120

gcagtacaat tcgcggcttg atctttggtt actctcattc tgatattggt tttgatcgcg     3180

gcggcaaagg taatatcgat agctataccc tgggggctta tgccggttgg gagcatcaga     3240

acggtgccta tgttgatggg gtggtgaaag ttgaccgttt tgccaacacc atccatggca     3300

agatgagtaa tggggcaaca gcgtttggcg attacaatag taacggcgcg ggtgctcatg     3360

ttgagagcgg gttccgttgg gttgacggat tgtggagtgt tagaccctat ctggccttta     3420

ccggctttac cacagatggt caggactaca cgttatcaaa cggcatgcgc gcggatgtgg     3480

gaaatacccg gatattacgc gctgaagcgg gaacggcggt aagctatcac atggacctgc     3540

aaaacggtac gacgctggaa ccctggctga aagcggccgt gcgtcaggaa tacgccgatt     3600

ctaaccaggt gaaagttaat gacgatggca aatttaataa tgatgtggct ggaaccagtg     3660

gcgtttatca ggctggtata aggtcatcgt ttaccccgac gttaagcggt catttgtcag     3720

tcagctatgg caatggcgca ggggtagaat cgccgtggaa tactcaggcg ggtgtggtct     3780

ggacgttctg a                                                          3791


<210>  8
<211>  1221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic yejO mutated protein

<400>  8

Met His Gln Ser Gly Ser Val Ser Leu Cys Arg Ser Ala Ile Ser Val 
1               5                   10                  15      


Leu Val Ala Thr Ala Leu Arg Lys Val Arg Thr Ser Pro Tyr Glu Ile 
            20                  25                  30          


Met Phe Val Ile Trp Ser His Arg Thr Gly Phe Ile Met Ser His Gln 
        35                  40                  45              


Leu Thr Phe Ala Asp Ser Glu Phe Ser Ser Lys Arg Arg Gln Thr Arg 
    50                  55                  60                  


Lys Glu Ile Phe Leu Ser Arg Met Glu Gln Ile Leu Pro Trp Gln Asn 
65                  70                  75                  80  


Met Val Glu Val Ile Glu Pro Phe Tyr Pro Lys Ala Gly Asn Gly Arg 
                85                  90                  95      


Arg Pro Tyr Pro Leu Glu Thr Met Leu Arg Ile His Cys Met Gln His 
            100                 105                 110         


Trp Tyr Asn Leu Ser Asp Gly Ala Met Glu Asp Ala Leu Tyr Glu Ile 
        115                 120                 125             


Ala Ser Met Arg Leu Phe Ala Arg Leu Ser Leu Asp Ser Ala Leu Pro 
    130                 135                 140                 


Asp Arg Thr Thr Ile Met Asn Phe Arg His Leu Leu Glu Gln His Gln 
145                 150                 155                 160 


Leu Ala Arg Gln Leu Phe Lys Thr Ile Asn Arg Trp Leu Ala Glu Ala 
                165                 170                 175     


Gly Val Met Met Thr Gln Gly Thr Leu Val Asp Ala Thr Ile Ile Glu 
            180                 185                 190         


Ala Pro Ser Ser Thr Lys Asn Lys Glu Gln Gln Arg Asp Pro Glu Met 
        195                 200                 205             


His Gln Thr Lys Lys Gly Asn Gln Trp His Phe Gly Met Lys Ala His 
    210                 215                 220                 


Ile Gly Val Asp Ala Lys Ser Gly Leu Thr His Ser Leu Val Thr Thr 
225                 230                 235                 240 


Ala Ala Asn Glu His Asp Leu Asn Gln Leu Gly Asn Leu Leu His Gly 
                245                 250                 255     


Glu Glu Gln Phe Val Ser Ala Asp Ala Gly Tyr Gln Gly Ala Pro Gln 
            260                 265                 270         


Arg Glu Glu Leu Ala Glu Val Asp Val Asp Trp Leu Ile Ala Glu Arg 
        275                 280                 285             


Pro Gly Lys Val Arg Thr Leu Lys Gln His Pro Arg Lys Asn Lys Thr 
    290                 295                 300                 


Ala Ile Asn Ile Glu Tyr Met Lys Ala Ser Ile Arg Ala Arg Val Glu 
305                 310                 315                 320 


His Pro Phe Arg Ile Ile Lys Arg Gln Phe Gly Phe Val Lys Ala Arg 
                325                 330                 335     


Tyr Lys Gly Leu Leu Lys Asn Asp Asn Gln Leu Ala Met Leu Phe Thr 
            340                 345                 350         


Leu Ala Asn Leu Phe Arg Ala Asp Gln Met Ile Arg Gln Trp Glu Arg 
        355                 360                 365             


Ser His Lys Leu Gly Ile Thr Pro Met Ala Lys Lys Arg Ser Lys Ala 
    370                 375                 380                 


Asp Ser Arg His Leu Arg Glu Lys Lys Ser Ala Gln Thr Arg Asn Glu 
385                 390                 395                 400 


Met Thr Glu Ser Ala Glu Lys Asn Phe Pro Ala Tyr Ser His Leu Pro 
                405                 410                 415     


Tyr Ile His Pro His Trp His Gln Leu Leu Ser Met Val Arg Gln Leu 
            420                 425                 430         


Met Val Leu Ser Trp Lys Lys Ile Ser Ser Trp Phe Met Gly Pro Pro 
        435                 440                 445             


Ile Ile Arg Lys Ser Ile Leu Ala Glu Asn Ser Ile Lys Asn Leu Val 
    450                 455                 460                 


Val Ile Ile Leu Lys Leu Thr Glu Gly Ile Ser Thr Leu Lys Met Ala 
465                 470                 475                 480 


Pro Gln Asn Thr Gln Tyr Met Thr Val Ile Lys Leu Phe Lys Trp Val 
                485                 490                 495     


Ala Arg Gln Thr Arg Leu Arg Ser Ile Met Val Cys Tyr Arg Phe Met 
            500                 505                 510         


Ala Gln Arg Met Ile Pro Arg Leu Lys Ala Gly Ala Ser Leu Lys Lys 
        515                 520                 525             


Met Gly Gly Pro Ser Leu Ser Leu Ser Lys Arg Glu Asp Tyr Trp Arg 
    530                 535                 540                 


Leu Lys Arg Gly Asp Leu His Leu Arg Ile Arg Lys Gln Ala Val Leu 
545                 550                 555                 560 


Leu Lys Gln Pro Arg Gly Pro Trp Arg Tyr Ser Glu Gln Thr Val Ser 
                565                 570                 575     


Val Ser Ser Ile Ser Arg Met Val Leu Leu Ile Ile Cys Cys Trp Lys 
            580                 585                 590         


Thr Ala Glu Val Cys Glu Leu Lys Lys Met Thr Ser Leu Ile Ile Pro 
        595                 600                 605             


Leu Ile Val Ala Ala Tyr Trp Arg Leu Trp Met Ala Gly Leu Leu Ala 
    610                 615                 620                 


Leu Ile Lys Lys Gln Ala Glu Asn Leu Ser Gln Arg Met Arg Trp Lys 
625                 630                 635                 640 


Val Val Gln Thr Val Lys Ala Asn Leu Val Lys Met Val Cys Gln Lys 
                645                 650                 655     


Ile Met Asn Trp Met Met Val Pro Gly Ser Leu Leu Trp Arg Thr Arg 
            660                 665                 670         


Arg Pro Leu Ile Leu Ser Leu Ile Ser Met Pro Leu Cys Asn Arg Trp 
        675                 680                 685             


Glu Arg Ile Leu Val Arg Lys Cys Arg Gln Met Arg Tyr Met Ile Ser 
    690                 695                 700                 


Val Asp His Ile Arg Met Glu Val Ser Arg Ile Pro Gln Lys Pro Ser 
705                 710                 715                 720 


Leu Lys Ile Trp Leu Ser Thr Met Ala Ala Leu Thr Ser Gly Leu Ala 
                725                 730                 735     


Gln Trp Leu Thr Phe Gln Ser Glu Gly Met Met Ala Phe Leu Arg Ser 
            740                 745                 750         


Ser Arg Lys Ile Met His Pro Gln Cys Trp Trp Val Arg Trp Phe Leu 
        755                 760                 765             


Arg Ala Leu Leu Leu Glu Arg Met Val Pro Trp Ile Pro Ala Lys Arg 
    770                 775                 780                 


Thr Phe Arg Ser Lys Ile Ala Tyr Gly Pro Ser Leu Pro Ile Ser Leu 
785                 790                 795                 800 


Arg Arg Thr Lys Thr Pro Ser Ser Thr Pro Thr Leu Arg Cys Leu Thr 
                805                 810                 815     


Gln Met Leu Trp Met Ser Gln Leu Val His Gln Arg Gln Val Arg Lys 
            820                 825                 830         


Ile Ser Leu Arg Pro Pro Ile Pro Cys Arg Glu Thr Ala Ile Phe Ile 
        835                 840                 845             


Cys Val Pro Ile Trp Leu Ile Ile Arg Ala Ile Ser Ser Thr Ser Pro 
    850                 855                 860                 


Val Arg Gln Gln Val Ile Ser Lys Tyr Ser Arg Thr Pro Val Pro Ala 
865                 870                 875                 880 


Arg Gln Gln Glu Ile Ala Leu His Trp Gln Arg Ala Ala Val Met Leu 
                885                 890                 895     


His Leu Arg Trp Ala Met Pro Glu Ala Leu Leu Ile Ser Val Arg Met 
            900                 905                 910         


Asn Ile Pro Cys Trp Ile Met Ala Thr Ile Ala Gly Val Trp Gln Arg 
        915                 920                 925             


Ile Ala Arg Lys Leu Pro Leu Gln Pro Leu Met Cys Ile Trp Arg Pro 
    930                 935                 940                 


His Asn Arg Trp Tyr Leu Met Gln Asn Trp Thr Pro Cys Val Ser Val 
945                 950                 955                 960 


Leu Val Ala Lys Ala Leu Val Thr Ile Arg Arg Cys Gly Val Arg Gln 
                965                 970                 975     


Leu Thr Pro Ala Thr Thr Pro Leu Met Arg Glu Leu Val Leu Ser Lys 
            980                 985                 990         


His Arg Ala Arg Ser Val Ser Ile  Ala Val Ser Pro Val  Lys Lys Ala 
        995                 1000                 1005             


Val Gln  Phe Ala Ala Ser Leu  Val Thr Leu Ile Leu  Ile Leu Val 
    1010                 1015                 1020             


Leu Ile  Ala Ala Ala Lys Val  Ile Ser Ile Ala Ile  Pro Trp Gly 
    1025                 1030                 1035             


Leu Met  Pro Val Gly Ser Ile  Arg Thr Val Pro Met  Leu Met Gly 
    1040                 1045                 1050             


Trp Lys  Leu Thr Val Leu Pro  Thr Pro Ser Met Ala  Arg Val Met 
    1055                 1060                 1065             


Gly Gln  Gln Arg Leu Ala Ile  Thr Ile Val Thr Ala  Arg Val Leu 
    1070                 1075                 1080             


Met Leu  Arg Ala Gly Ser Val  Gly Leu Thr Asp Cys  Gly Val Leu 
    1085                 1090                 1095             


Asp Pro  Ile Trp Pro Leu Pro  Ala Leu Pro Gln Met  Val Arg Thr 
    1100                 1105                 1110             


Thr Arg  Tyr Gln Thr Ala Cys  Ala Arg Met Trp Glu  Ile Pro Gly 
    1115                 1120                 1125             


Tyr Tyr  Ala Leu Lys Arg Glu  Arg Arg Ala Ile Thr  Trp Thr Cys 
    1130                 1135                 1140             


Lys Thr  Val Arg Arg Trp Asn  Pro Gly Lys Arg Pro  Cys Val Arg 
    1145                 1150                 1155             


Asn Thr  Pro Ile Leu Thr Arg  Lys Leu Met Thr Met  Ala Asn Leu 
    1160                 1165                 1170             


Ile Met  Met Trp Leu Glu Pro  Val Ala Phe Ile Arg  Leu Val Gly 
    1175                 1180                 1185             


His Arg  Leu Pro Arg Arg Ala  Val Ile Cys Gln Ser  Ala Met Ala 
    1190                 1195                 1200             


Met Ala  Gln Gly Asn Arg Arg  Gly Ile Leu Arg Arg  Val Trp Ser 
    1205                 1210                 1215             


Gly Arg  Ser 
    1220     


