                         SEQUENCE LISTING

<110>  UCL Business Ltd
 
<120>  TREATMENT OF HEPATITIS B VIRUS (HBV) INFECTION

<130>  P118760PCT

<140>  PCT/GB2020/053034
<141>  2020-11-27

<150>  GB 1917498.6
<151>  2019-11-29

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Leu Ala Ala Leu Leu Arg Ser Gly Ala Arg Ser Arg Ser 
1               5                   10                  15      


Pro Leu Leu Arg Arg Leu Val Gln Glu Ile Arg Tyr Val Glu Arg Ser 
            20                  25                  30          


Tyr Val Ser Lys Pro Thr Leu Lys Glu Val Val Ile Val Ser Ala Thr 
        35                  40                  45              


Arg Thr Pro Ile Gly Ser Phe Leu Gly Ser Leu Ser Leu Leu Pro Ala 
    50                  55                  60                  


Thr Lys Leu Gly Ser Ile Ala Ile Gln Gly Ala Ile Glu Lys Ala Gly 
65                  70                  75                  80  


Ile Pro Lys Glu Glu Val Lys Glu Ala Tyr Met Gly Asn Val Leu Gln 
                85                  90                  95      


Gly Gly Glu Gly Gln Ala Pro Thr Arg Gln Ala Val Leu Gly Ala Gly 
            100                 105                 110         


Leu Pro Ile Ser Thr Pro Cys Thr Thr Ile Asn Lys Val Cys Ala Ser 
        115                 120                 125             


Gly Met Lys Ala Ile Met Met Ala Ser Gln Ser Leu Met Cys Gly His 
    130                 135                 140                 


Gln Asp Val Met Val Ala Gly Gly Met Glu Ser Met Ser Asn Val Pro 
145                 150                 155                 160 


Tyr Val Met Asn Arg Gly Ser Thr Pro Tyr Gly Gly Val Lys Leu Glu 
                165                 170                 175     


Asp Leu Ile Val Lys Asp Gly Leu Thr Asp Val Tyr Asn Lys Ile His 
            180                 185                 190         


Met Gly Ser Cys Ala Glu Asn Thr Ala Lys Lys Leu Asn Ile Ala Arg 
        195                 200                 205             


Asn Glu Gln Asp Ala Tyr Ala Ile Asn Ser Tyr Thr Arg Ser Lys Ala 
    210                 215                 220                 


Ala Trp Glu Ala Gly Lys Phe Gly Asn Glu Val Ile Pro Val Thr Val 
225                 230                 235                 240 


Thr Val Lys Gly Gln Pro Asp Val Val Val Lys Glu Asp Glu Glu Tyr 
                245                 250                 255     


Lys Arg Val Asp Phe Ser Lys Val Pro Lys Leu Lys Thr Val Phe Gln 
            260                 265                 270         


Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Thr Leu Asn Asp 
        275                 280                 285             


Gly Ala Ala Ala Leu Val Leu Met Thr Ala Asp Ala Ala Lys Arg Leu 
    290                 295                 300                 


Asn Val Thr Pro Leu Ala Arg Ile Val Ala Phe Ala Asp Ala Ala Val 
305                 310                 315                 320 


Glu Pro Ile Asp Phe Pro Ile Ala Pro Val Tyr Ala Ala Ser Met Val 
                325                 330                 335     


Leu Lys Asp Val Gly Leu Lys Lys Glu Asp Ile Ala Met Trp Glu Val 
            340                 345                 350         


Asn Glu Ala Phe Ser Leu Val Val Leu Ala Asn Ile Lys Met Leu Glu 
        355                 360                 365             


Ile Asp Pro Gln Lys Val Asn Ile Asn Gly Gly Ala Val Ser Leu Gly 
    370                 375                 380                 


His Pro Ile Gly Met Ser Gly Ala Arg Ile Val Gly His Leu Thr His 
385                 390                 395                 400 


Ala Leu Lys Gln Gly Glu Tyr Gly Leu Ala Ser Ile Cys Asn Gly Gly 
                405                 410                 415     


Gly Gly Ala Ser Ala Met Leu Ile Gln Lys Leu 
            420                 425         


<210>  2
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Ala Gly Ser Asp Pro Val Val Ile Val Ser Ala Ala Arg Thr 
1               5                   10                  15      


Ile Ile Gly Ser Phe Asn Gly Ala Leu Ala Ala Val Pro Val Gln Asp 
            20                  25                  30          


Leu Gly Ser Thr Val Ile Lys Glu Val Leu Lys Arg Ala Thr Val Ala 
        35                  40                  45              


Pro Glu Asp Val Ser Glu Val Ile Phe Gly His Val Leu Ala Ala Gly 
    50                  55                  60                  


Cys Gly Gln Asn Pro Val Arg Gln Ala Ser Val Gly Ala Gly Ile Pro 
65                  70                  75                  80  


Tyr Ser Val Pro Ala Trp Ser Cys Gln Met Ile Cys Gly Ser Gly Leu 
                85                  90                  95      


Lys Ala Val Cys Leu Ala Val Gln Ser Ile Gly Ile Gly Asp Ser Ser 
            100                 105                 110         


Ile Val Val Ala Gly Gly Met Glu Asn Met Ser Lys Ala Pro His Leu 
        115                 120                 125             


Ala Tyr Leu Arg Thr Gly Val Lys Ile Gly Glu Met Pro Leu Thr Asp 
    130                 135                 140                 


Ser Ile Leu Cys Asp Gly Leu Thr Asp Ala Phe His Asn Cys His Met 
145                 150                 155                 160 


Gly Ile Thr Ala Glu Asn Val Ala Lys Lys Trp Gln Val Ser Arg Glu 
                165                 170                 175     


Asp Gln Asp Lys Val Ala Val Leu Ser Gln Asn Arg Thr Glu Asn Ala 
            180                 185                 190         


Gln Lys Ala Gly His Phe Asp Lys Glu Ile Val Pro Val Leu Val Ser 
        195                 200                 205             


Thr Arg Lys Gly Leu Ile Glu Val Lys Thr Asp Glu Phe Pro Arg His 
    210                 215                 220                 


Gly Ser Asn Ile Glu Ala Met Ser Lys Leu Lys Pro Tyr Phe Leu Thr 
225                 230                 235                 240 


Asp Gly Thr Gly Thr Val Thr Pro Ala Asn Ala Ser Gly Ile Asn Asp 
                245                 250                 255     


Gly Ala Ala Ala Val Val Leu Met Lys Lys Ser Glu Ala Asp Lys Arg 
            260                 265                 270         


Gly Leu Thr Pro Leu Ala Arg Ile Val Ser Trp Ser Gln Val Gly Val 
        275                 280                 285             


Glu Pro Ser Ile Met Gly Ile Gly Pro Ile Pro Ala Ile Lys Gln Ala 
    290                 295                 300                 


Val Thr Lys Ala Gly Trp Ser Leu Glu Asp Val Asp Ile Phe Glu Ile 
305                 310                 315                 320 


Asn Glu Ala Phe Ala Ala Val Ser Ala Ala Ile Val Lys Glu Leu Gly 
                325                 330                 335     


Leu Asn Pro Glu Lys Val Asn Ile Glu Gly Gly Ala Ile Ala Leu Gly 
            340                 345                 350         


His Pro Leu Gly Ala Ser Gly Cys Arg Ile Leu Val Thr Leu Leu His 
        355                 360                 365             


Thr Leu Glu Arg Met Gly Arg Ser Arg Gly Val Ala Ala Leu Cys Ile 
    370                 375                 380                 


Gly Gly Gly Met Gly Ile Ala Met Cys Val Gln Arg Glu 
385                 390                 395         


<210>  3
<211>  1537
<212>  DNA
<213>  Homo sapiens

<400>  3
agtctacgcc tgtggagccg atactcagcc ctctgcgacc atggctgtgc tggcggcact       60

tctgcgcagc ggcgcccgca gccgcagccc cctgctccgg aggctggtgc aggaaataag      120

atatgtggaa cggagttatg tatcaaaacc cactttgaag gaagtggtca tagtaagtgc      180

tacaagaaca cccattggat cttttttagg cagcctttcc ttgctgccag ccactaagct      240

tggttccatt gcaattcagg gagccattga aaaggcaggg attccaaaag aagaagtgaa      300

agaagcatac atgggtaatg ttctacaagg aggtgaagga caagctccta caaggcaggc      360

agtattgggt gcaggcttac ctatttctac tccatgtacc accataaaca aagtttgtgc      420

ttcaggaatg aaagccatca tgatggcctc tcaaagtctt atgtgtggac atcaggatgt      480

gatggtggca ggtgggatgg agagcatgtc caatgttcca tatgtaatga acagaggatc      540

aacaccatat ggtggggtaa agcttgaaga tttgattgta aaagacgggc taactgatgt      600

ctacaataaa attcatatgg gcagctgtgc tgagaataca gcaaagaagc tgaatattgc      660

acgaaatgaa caggacgctt atgctattaa ttcttatacc agaagtaaag cagcatggga      720

agctgggaaa tttggaaatg aagttattcc tgtcacagtt acagtaaaag gtcaaccaga      780

tgtagtggtg aaagaagatg aagaatataa acgtgttgat tttagcaaag ttccaaagct      840

gaagacagtt ttccagaaag aaaatggcac agtaacagct gccaatgcca gtacactgaa      900

tgatggagca gctgctctgg ttctcatgac ggcagatgca gcgaagaggc tcaatgttac      960

accactggca agaatagtag catttgctga cgctgctgta gaacctattg attttccaat     1020

tgctcctgta tatgctgcat ctatggttct taaagatgtg ggattgaaaa aagaagatat     1080

tgcaatgtgg gaagtaaatg aagcctttag tctggttgta ctagcaaaca ttaaaatgtt     1140

ggagattgat ccccaaaaag tgaatatcaa tggaggagct gtttctctgg gacatccaat     1200

tgggatgtct ggagccagga ttgttggtca tttgactcat gccttgaagc aaggagaata     1260

cggtcttgcc agtatttgca atggaggagg aggtgcttct gccatgctaa ttcagaagct     1320

gtagacaacc tctgctattt aaggagacaa ccctatgtga ccagaaggcc tgctgtaatc     1380

agtgtgacta ctgtgggtca gcttatattc agataagctg tttcattttt tattattttc     1440

tatgttaact tttaaaaatc aaaatgatga aatcccaaaa cattttgaaa ttaaaaataa     1500

atttcttctt ctgctttttt cttggtaacc ttgaaaa                              1537


<210>  4
<211>  1520
<212>  DNA
<213>  Homo sapiens

<400>  4
agcttgcagg cagcgcaggg cagacggcgg caggagaagc aagatgaatg caggctcaga       60

tcctgtggtc atcgtctcgg cggcgcggac catcataggt tccttcaatg gtgccttagc      120

tgctgttcct gtccaggacc tgggctccac tgtcatcaaa gaagtcttga agagggccac      180

tgtggctccg gaagatgtgt ctgaggtcat ctttggacat gtcttggcag caggctgtgg      240

gcagaatcct gttagacaag ccagtgtggg tgcaggaatt ccctactctg ttccagcatg      300

gagctgccag atgatctgtg ggtcaggcct aaaagctgtg tgccttgcag tccagtcaat      360

agggatagga gactccagca ttgtggttgc aggaggcatg gaaaatatga gcaaggctcc      420

tcacttggct tacttgagaa caggagtaaa gataggtgag atgccactga ctgacagtat      480

actctgtgat ggtcttacag atgcatttca caactgtcat atgggtatta cagctgaaaa      540

tgtagccaaa aaatggcaag tgagtagaga agatcaggac aaggttgcag ttctgtccca      600

gaacaggaca gagaatgcac agaaagctgg ccattttgac aaagagattg taccagtttt      660

ggtgtcaact agaaaaggtc ttattgaagt taaaacagat gagtttcctc gccatgggag      720

caacatagaa gccatgtcca agctaaagcc ttactttctt actgatggaa cgggaacagt      780

caccccagcc aatgcttcag gaataaatga tggtgctgca gctgtcgttc ttatgaagaa      840

gtcagaagct gataaacgtg ggcttacacc tttagcacgg atagtttcct ggtcccaagt      900

gggtgtggag ccttccatta tgggaatagg accaattcca gccataaagc aagctgttac      960

aaaagcaggt tggtcactgg aagatgttga catatttgaa atcaatgaag cctttgcagc     1020

tgtctctgct gcaatagtta aagaacttgg attaaaccca gagaaggtca atattgaagg     1080

aggggctata gccttgggcc accctcttgg agcatctggc tgtcgaattc ttgtgaccct     1140

gttacacaca ctggagagaa tgggcagaag tcgtggtgtt gcagccctgt gcattggggg     1200

tgggatggga atagcaatgt gtgttcagag agaatgaatt gcttaaactt tgaacaacct     1260

caatttcttt ttaaactaat aaagtactag gttgcaatat gtgaaatcag aggaccaaag     1320

tacagatgga aaccatttcc tacatcacaa aaacccaagt ttacagcttg tactttactt     1380

taatgtgtaa tactcaactc aaggtacaag acaattgcat ttaacattgt tataaataaa     1440

aggaacatca gatcaatcat taagggctcc agagtgaaca gcatcttcat aacttccatg     1500

tttatcatct ttactttctg                                                 1520


