                         SEQUENCE LISTING

<110>  Firmenich
        
 
<120>  NOVEL POLYPEPTIDES FOR PRODUCING ALBICANOL AND/OR DRIMENOL 
       COMPOUNDS

<130>  13150/WO

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  1599
<212>  DNA
<213>  Bazzania sp.


<220>
<221>  misc_feature
<223>  BazzHAD1_wt_nucleic acid sequence

<400>  1
atggctcctc ctttcggatt tattggtggg aatgcaacga gtgtgacgac ttccccagat       60

gtcctcgact acaactatga cggtggccct cctactggcc aatacaagag tttgatttta      120

gacattggtg gagtgttgct tcagcccaac cttgacagga gctatggcac gattgtacca      180

cctgtgcaat tcaaacgtat gttgcgctcg cacatctggt tcaattactc aatgggaaag      240

atgtctgcgg aggaagtgtt tcggcagctc tccgtgaagt ctggctaccc ggcagaagat      300

atccggagtt ttggtcgcaa agcgagagag tctcttgtcc ccatcacaca aataacggat      360

cttctgttca aactcagcaa ggaatcgaag gtcagactgt tctgtatgac caattgccct      420

gcagaagact tcgaatacct ctcacaggca tatcccaagc ttttcggctt gttcgagagg      480

atttttacgt cggcatccac cggtatgcgc aagccaaaca ggaatttctt ccgacatgta      540

ctccaggaga cgggaatcag agcgtcggag actattttcg tagacgacct ggtaccgaac      600

attatggccg ccgaggcgct ggacttcacg gcgattcacg tttctccaga gtcgcccgcc      660

gagaccgtga ggttgctgat gttccatctc cgtaagccag aagagcggct ggcggcggcg      720

cgcgactatc tcctgcgcaa ccgtggagtg gacaaagctc tctctctcac atctgatgga      780

gtccgagtcc aggtttattt cgaccacttc gtggtcgccg aagtgctcaa cgacgagcga      840

ttcttgccaa tcactgcagc tccggagtcc gggactatga actttttccc gaaggaggaa      900

cgcaaagcga ctcgagatat aacgaccaat gcagtcacac acgtggacct tcccgatgat      960

cttgactcca cctctgtcgc cttatcggtc ctttacaaat tctccaaagt ggggatggag     1020

acggttcaaa gggtcctgga tatgatggag aaacgtgtgg atgatgacgg catttttcaa     1080

acgtacttcg atcctttgcg gctgcgtgtt gacccggtgg ccgctactaa caccgtctac     1140

ctcttccatc taggaggtcg tcccggacct actcagcaga cggaacaatt cctctccaag     1200

ttactggaaa agagatctta tctccgcggc acactctact accggacccc cgaggcattt     1260

ctctatcaac tcaccagatt ggtggtatca tttgaggagt atttcagaaa gacaggcttc     1320

ctggaaatgc tcaagaaaag gctgagtgag cgagtgggca tagagagcga tgcattcacg     1380

ttggcgatga ggattctagc gtgtgtgaat tgtggaatcc ctgttgctga gctgaacaga     1440

gatatggaca gactagcacg gatgcaaaat gtggatggtt catgggacgt ctgcccttac     1500

tacagctaca atgatcccaa gagttggttt gggaacgagc ttcttaccac agcttttgct     1560

gctgccgctc ttgagcagtc tgagcccaac tttaactga                            1599


<210>  2
<211>  1599
<212>  DNA
<213>  Bazzania sp.


<220>
<221>  misc_feature
<223>  BazzHAD1_E. coli optimized

<400>  2
atggctccgc cgttcggctt tatcggtggc aacgcgacca gcgttaccac cagcccggat       60

gtgctggact acaactatga tggtggcccg ccgaccggcc agtacaaaag cctgatcctg      120

gatattggtg gcgttctgct gcaaccgaac ctggaccgta gctatggcac catcgttccg      180

ccggtgcagt tcaagcgtat gctgcgtagc cacatttggt ttaactacag catgggtaaa      240

atgagcgcgg aggaagtttt ccgtcaactg agcgtgaaga gcggttatcc ggcggaggat      300

atccgtagct ttggccgtaa agcgcgtgaa agcctggttc cgatcaccca gattaccgac      360

ctgctgttca agctgagcaa agagagcaaa gtgcgtctgt tctgcatgac caactgcccg      420

gcggaggact ttgaatacct gagccaagcg tatccgaaac tgttcggtct gtttgaacgt      480

atttttacca gcgcgagcac cggcatgcgt aagccgaacc gtaacttctt tcgtcacgtg      540

ctgcaggaga ccggcatccg tgcgagcgaa accattttcg ttgacgatct ggtgccgaac      600

atcatggcgg cggaggcgct ggattttacc gcgattcacg ttagcccgga gagcccggcg      660

gaaaccgtgc gtctgctgat gttccacctg cgtaaaccgg aggaacgtct ggcggcggcg      720

cgtgactacc tgctgcgtaa ccgtggtgtt gataaagcgc tgagcctgac cagcgatggt      780

gtgcgtgttc aggtgtattt cgatcacttt gtggttgcgg aagtgctgaa cgacgaacgt      840

tttctgccga tcaccgcggc gccggaaagc ggcaccatga acttctttcc gaaagaggaa      900

cgcaaggcga cccgtgatat taccaccaac gcggttaccc acgtggatct gccggacgat      960

ctggacagca ccagcgttgc gctgagcgtg ctgtacaaat tcagcaaggt tggtatggag     1020

accgttcagc gtgtgctgga catgatggaa aagcgtgtgg acgatgacgg catcttccaa     1080

acctactttg atccgctgcg tctgcgtgtt gacccggtgg cggcgaccaa caccgtttac     1140

ctgttccatc tgggtggccg tccgggtccg acccagcaaa ccgagcagtt tctgagcaaa     1200

ctgctggaaa agcgtagcta tctgcgtggc accctgtact atcgtacccc ggaggcgttc     1260

ctgtaccaac tgacccgtct ggtggttagc ttcgaggaat attttcgtaa aaccggtttc     1320

ctggaaatgc tgaagaaacg tctgagcgag cgtgtgggca ttgaaagcga tgcgtttacc     1380

ctggcgatgc gtatcctggc gtgcgttaac tgcggtattc cggtggcgga gctgaaccgt     1440

gatatggacc gtctggcgcg tatgcagaac gttgatggta gctgggacgt gtgcccgtac     1500

tatagctaca acgacccgaa gagctggttc ggcaacgaac tgctgaccac cgcgtttgcg     1560

gcggcggcgc tggagcaaag cgaaccgaac ttcaactaa                            1599


<210>  3
<211>  532
<212>  PRT
<213>  Bazzania sp.


<220>
<221>  MISC_FEATURE
<223>  BazzHAD1_amino acid sequence

<400>  3

Met Ala Pro Pro Phe Gly Phe Ile Gly Gly Asn Ala Thr Ser Val Thr 
1               5                   10                  15      


Thr Ser Pro Asp Val Leu Asp Tyr Asn Tyr Asp Gly Gly Pro Pro Thr 
            20                  25                  30          


Gly Gln Tyr Lys Ser Leu Ile Leu Asp Ile Gly Gly Val Leu Leu Gln 
        35                  40                  45              


Pro Asn Leu Asp Arg Ser Tyr Gly Thr Ile Val Pro Pro Val Gln Phe 
    50                  55                  60                  


Lys Arg Met Leu Arg Ser His Ile Trp Phe Asn Tyr Ser Met Gly Lys 
65                  70                  75                  80  


Met Ser Ala Glu Glu Val Phe Arg Gln Leu Ser Val Lys Ser Gly Tyr 
                85                  90                  95      


Pro Ala Glu Asp Ile Arg Ser Phe Gly Arg Lys Ala Arg Glu Ser Leu 
            100                 105                 110         


Val Pro Ile Thr Gln Ile Thr Asp Leu Leu Phe Lys Leu Ser Lys Glu 
        115                 120                 125             


Ser Lys Val Arg Leu Phe Cys Met Thr Asn Cys Pro Ala Glu Asp Phe 
    130                 135                 140                 


Glu Tyr Leu Ser Gln Ala Tyr Pro Lys Leu Phe Gly Leu Phe Glu Arg 
145                 150                 155                 160 


Ile Phe Thr Ser Ala Ser Thr Gly Met Arg Lys Pro Asn Arg Asn Phe 
                165                 170                 175     


Phe Arg His Val Leu Gln Glu Thr Gly Ile Arg Ala Ser Glu Thr Ile 
            180                 185                 190         


Phe Val Asp Asp Leu Val Pro Asn Ile Met Ala Ala Glu Ala Leu Asp 
        195                 200                 205             


Phe Thr Ala Ile His Val Ser Pro Glu Ser Pro Ala Glu Thr Val Arg 
    210                 215                 220                 


Leu Leu Met Phe His Leu Arg Lys Pro Glu Glu Arg Leu Ala Ala Ala 
225                 230                 235                 240 


Arg Asp Tyr Leu Leu Arg Asn Arg Gly Val Asp Lys Ala Leu Ser Leu 
                245                 250                 255     


Thr Ser Asp Gly Val Arg Val Gln Val Tyr Phe Asp His Phe Val Val 
            260                 265                 270         


Ala Glu Val Leu Asn Asp Glu Arg Phe Leu Pro Ile Thr Ala Ala Pro 
        275                 280                 285             


Glu Ser Gly Thr Met Asn Phe Phe Pro Lys Glu Glu Arg Lys Ala Thr 
    290                 295                 300                 


Arg Asp Ile Thr Thr Asn Ala Val Thr His Val Asp Leu Pro Asp Asp 
305                 310                 315                 320 


Leu Asp Ser Thr Ser Val Ala Leu Ser Val Leu Tyr Lys Phe Ser Lys 
                325                 330                 335     


Val Gly Met Glu Thr Val Gln Arg Val Leu Asp Met Met Glu Lys Arg 
            340                 345                 350         


Val Asp Asp Asp Gly Ile Phe Gln Thr Tyr Phe Asp Pro Leu Arg Leu 
        355                 360                 365             


Arg Val Asp Pro Val Ala Ala Thr Asn Thr Val Tyr Leu Phe His Leu 
    370                 375                 380                 


Gly Gly Arg Pro Gly Pro Thr Gln Gln Thr Glu Gln Phe Leu Ser Lys 
385                 390                 395                 400 


Leu Leu Glu Lys Arg Ser Tyr Leu Arg Gly Thr Leu Tyr Tyr Arg Thr 
                405                 410                 415     


Pro Glu Ala Phe Leu Tyr Gln Leu Thr Arg Leu Val Val Ser Phe Glu 
            420                 425                 430         


Glu Tyr Phe Arg Lys Thr Gly Phe Leu Glu Met Leu Lys Lys Arg Leu 
        435                 440                 445             


Ser Glu Arg Val Gly Ile Glu Ser Asp Ala Phe Thr Leu Ala Met Arg 
    450                 455                 460                 


Ile Leu Ala Cys Val Asn Cys Gly Ile Pro Val Ala Glu Leu Asn Arg 
465                 470                 475                 480 


Asp Met Asp Arg Leu Ala Arg Met Gln Asn Val Asp Gly Ser Trp Asp 
                485                 490                 495     


Val Cys Pro Tyr Tyr Ser Tyr Asn Asp Pro Lys Ser Trp Phe Gly Asn 
            500                 505                 510         


Glu Leu Leu Thr Thr Ala Phe Ala Ala Ala Ala Leu Glu Gln Ser Glu 
        515                 520                 525             


Pro Asn Phe Asn 
    530         


<210>  4
<211>  1422
<212>  DNA
<213>  Bazzania sp.


<220>
<221>  misc_feature
<223>  BazzHAD2_wt_nucleic acid sequence

<400>  4
atggaaagac ctcatttcga cactctgatc atggacctgg gaggtgttct tgtcgacttc       60

tctcttcaaa catccacatc cacttctgtg aaatctctca agtttgtatt acgttccgcc      120

acctgggcag cttacgagtg cggccatatg tcagaatcgg attgctatgc tgcagtggct      180

aaagatcttg gaagctctgc aaacgcatct caagttggtg aagccatctc agaagttcga      240

aagtcactgc aggtcaatga agatttgata ggggtgattc gggagctcaa agcccagaac      300

ggccttcgag tttacgtaat gtccaacata ccacaaccag acttcgatgc cgtcaaagct      360

aagtcagcga gctggggagt attcgatggc atgtatccct cgtatgcggt gggcacccat      420

aagcccgatc ttgctttcta tcgacacgta ctcgaagaga caaacacaga ccctctcaaa      480

gcgatctttg tcgacgacag cttacaaaat gtcattgcag ccagatcttt tggattgaca      540

ggaattatct acaatgatac tgtcaatgct gctcgaacgc tgcgaaatct ccttggtgat      600

cctatcttga gaggtgagca gtacctttcg tcccacgctg gacaattgct gtctatctca      660

gacacaggaa cccccttccc agataacttt tcacagcttt taattttgga tgctaccgga      720

aaccgtgatc ttgttgttct tgaaaaccct cagcgaacat ggaactactt catcggaaag      780

cctgtgttga cgtctgaaac attccctgat gatctagata cgacatctat cgccctcatg      840

gcattgaatg tagacctaga ggtggccaat tctgtgatgg atgagatgct ggagtttaga      900

aacagtgatg gattgtttct gacgtacttt gacgaaacaa ggccgcgggt agatgctgtt      960

gtcaatgtta atgttcttcg tctcttccat cgacatgaac gggagagaga ggcccagcaa     1020

ccgctggagt ggattaccaa cgtccttacc caccgagcgt atgttgatgg cacactattt     1080

tactaccatg ctgagagctt cttatatttc ctttcgcgac tgttctgtga gaactccagc     1140

gtccaatcac gatttcaaga gcttcttgaa caacgcctgc gggaacgaat tggaaccccg     1200

ggcgacgcac tgagtctagc catgcgtgca ttagcatgcc agatgctggg aatcgatagt     1260

tctaccgacg ttcgcgctct tctgcccttg caatgcgacg acggcggttg ggaagctggc     1320

tgggtgtgca gatacggttc aaatggtatg cgcgttggaa gccggggata cactacggct     1380

ttggctataa atgctatcag aggggcaaga gtctcgaggt ga                        1422


<210>  5
<211>  1422
<212>  DNA
<213>  Bazzania sp.


<220>
<221>  misc_feature
<223>  BazzHAD2_E. coli optimized

<400>  5
atggaacgtc cgcacttcga caccctgatc atggatctgg gtggcgtgct ggttgacttt       60

agcctgcaga ccagcaccag caccagcgtt aagagcctga aatttgtgct gcgtagcgcg      120

acctgggcgg cgtacgaatg cggtcacatg agcgagagcg actgctatgc ggcggttgcg      180

aaggatctgg gtagcagcgc gaacgcgagc caagtgggtg aagcgatcag cgaggttcgt      240

aagagcctgc aagtgaacga agatctgatc ggtgttattc gtgagctgaa agcgcagaac      300

ggcctgcgtg tgtacgttat gagcaacatt ccgcaaccgg acttcgatgc ggttaaggcg      360

aaaagcgcga gctggggtgt gtttgatggc atgtacccga gctatgcggt tggcacccac      420

aagccggacc tggcgtttta tcgtcacgtg ctggaggaaa ccaacaccga tccgctgaaa      480

gcgatcttcg ttgacgatag cctgcaaaac gtgattgcgg cgcgtagctt tggtctgacc      540

ggcatcattt acaacgacac cgtgaacgcg gcgcgtaccc tgcgtaacct gctgggtgat      600

ccgatcctgc gtggcgaaca gtatctgagc agccacgcgg gtcaactgct gagcattagc      660

gacaccggca ccccgttccc ggataacttt agccagctgc tgattctgga cgcgaccggt      720

aaccgtgatc tggtggttct ggaaaacccg caacgtacct ggaactactt catcggcaaa      780

ccggttctga ccagcgagac ctttccggac gatctggaca ccaccagcat tgcgctgatg      840

gcgctgaacg tggacctgga agttgcgaac agcgtgatgg atgaaatgct ggagttccgt      900

aacagcgacg gtctgttcct gacctacttt gacgagaccc gtccgcgtgt ggatgcggtg      960

gttaacgtga acgttctgcg tctgtttcac cgtcacgagc gtgaacgtga ggcgcagcaa     1020

ccgctggagt ggattaccaa cgttctgacc caccgtgcgt acgtggacgg caccctgttc     1080

tactatcacg cggaaagctt cctgtatttt ctgagccgtc tgttctgcga gaacagcagc     1140

gttcagagcc gttttcaaga actgctggag cagcgtctgc gtgaacgtat tggcaccccg     1200

ggtgatgcgc tgagcctggc gatgcgtgcg ctggcgtgcc agatgctggg tattgacagc     1260

agcaccgatg tgcgtgcgct gctgccgctg caatgcgatg atggtggctg ggaggcgggt     1320

tgggtttgcc gttacggtag caacggcatg cgtgtgggta gccgtggcta taccaccgcg     1380

ctggcgatca acgcgattcg tggtgcgcgt gttagccgtt aa                        1422


<210>  6
<211>  473
<212>  PRT
<213>  Bazzania sp.


<220>
<221>  MISC_FEATURE
<223>  BazzHAD2_amino acid sequence

<400>  6

Met Glu Arg Pro His Phe Asp Thr Leu Ile Met Asp Leu Gly Gly Val 
1               5                   10                  15      


Leu Val Asp Phe Ser Leu Gln Thr Ser Thr Ser Thr Ser Val Lys Ser 
            20                  25                  30          


Leu Lys Phe Val Leu Arg Ser Ala Thr Trp Ala Ala Tyr Glu Cys Gly 
        35                  40                  45              


His Met Ser Glu Ser Asp Cys Tyr Ala Ala Val Ala Lys Asp Leu Gly 
    50                  55                  60                  


Ser Ser Ala Asn Ala Ser Gln Val Gly Glu Ala Ile Ser Glu Val Arg 
65                  70                  75                  80  


Lys Ser Leu Gln Val Asn Glu Asp Leu Ile Gly Val Ile Arg Glu Leu 
                85                  90                  95      


Lys Ala Gln Asn Gly Leu Arg Val Tyr Val Met Ser Asn Ile Pro Gln 
            100                 105                 110         


Pro Asp Phe Asp Ala Val Lys Ala Lys Ser Ala Ser Trp Gly Val Phe 
        115                 120                 125             


Asp Gly Met Tyr Pro Ser Tyr Ala Val Gly Thr His Lys Pro Asp Leu 
    130                 135                 140                 


Ala Phe Tyr Arg His Val Leu Glu Glu Thr Asn Thr Asp Pro Leu Lys 
145                 150                 155                 160 


Ala Ile Phe Val Asp Asp Ser Leu Gln Asn Val Ile Ala Ala Arg Ser 
                165                 170                 175     


Phe Gly Leu Thr Gly Ile Ile Tyr Asn Asp Thr Val Asn Ala Ala Arg 
            180                 185                 190         


Thr Leu Arg Asn Leu Leu Gly Asp Pro Ile Leu Arg Gly Glu Gln Tyr 
        195                 200                 205             


Leu Ser Ser His Ala Gly Gln Leu Leu Ser Ile Ser Asp Thr Gly Thr 
    210                 215                 220                 


Pro Phe Pro Asp Asn Phe Ser Gln Leu Leu Ile Leu Asp Ala Thr Gly 
225                 230                 235                 240 


Asn Arg Asp Leu Val Val Leu Glu Asn Pro Gln Arg Thr Trp Asn Tyr 
                245                 250                 255     


Phe Ile Gly Lys Pro Val Leu Thr Ser Glu Thr Phe Pro Asp Asp Leu 
            260                 265                 270         


Asp Thr Thr Ser Ile Ala Leu Met Ala Leu Asn Val Asp Leu Glu Val 
        275                 280                 285             


Ala Asn Ser Val Met Asp Glu Met Leu Glu Phe Arg Asn Ser Asp Gly 
    290                 295                 300                 


Leu Phe Leu Thr Tyr Phe Asp Glu Thr Arg Pro Arg Val Asp Ala Val 
305                 310                 315                 320 


Val Asn Val Asn Val Leu Arg Leu Phe His Arg His Glu Arg Glu Arg 
                325                 330                 335     


Glu Ala Gln Gln Pro Leu Glu Trp Ile Thr Asn Val Leu Thr His Arg 
            340                 345                 350         


Ala Tyr Val Asp Gly Thr Leu Phe Tyr Tyr His Ala Glu Ser Phe Leu 
        355                 360                 365             


Tyr Phe Leu Ser Arg Leu Phe Cys Glu Asn Ser Ser Val Gln Ser Arg 
    370                 375                 380                 


Phe Gln Glu Leu Leu Glu Gln Arg Leu Arg Glu Arg Ile Gly Thr Pro 
385                 390                 395                 400 


Gly Asp Ala Leu Ser Leu Ala Met Arg Ala Leu Ala Cys Gln Met Leu 
                405                 410                 415     


Gly Ile Asp Ser Ser Thr Asp Val Arg Ala Leu Leu Pro Leu Gln Cys 
            420                 425                 430         


Asp Asp Gly Gly Trp Glu Ala Gly Trp Val Cys Arg Tyr Gly Ser Asn 
        435                 440                 445             


Gly Met Arg Val Gly Ser Arg Gly Tyr Thr Thr Ala Leu Ala Ile Asn 
    450                 455                 460                 


Ala Ile Arg Gly Ala Arg Val Ser Arg 
465                 470             


<210>  7
<211>  1452
<212>  DNA
<213>  Bazzania sp.


<220>
<221>  misc_feature
<223>  BazzHAD3_wt_nucleic acid sequence

<400>  7
atgcctgctt taagctcgca tatggagcca cctaattttg acaccctgat cctggacctg       60

ggagatgtcc ttgtgggagg ctctcttcaa ggctcttacg ccttggccat gaagagaatt      120

ctgaaactct cattacgtac cccgacgtgg ggaaaatacg agtgcggcca attatcagaa      180

ttagattgct atgacgctgt ggctgaagat cttgggaact ccacaagctc cgctcaagtg      240

ggtgaggtcg tctcagaagc tcgaaagtca ttgcaggtca atgaagacct gataaaggtg      300

cttcaggagc taaaggctga gaacaatctc cgggtttatg tcatgtccaa tatacccaag      360

ccggatttgg ctgttgtgaa ggccaagtca gtgaactggg gagtcatcga tggctggtat      420

ccctcttatg ctgtgggctt ccacaagccg gatctcgctt tctaccggca tgtacttgaa      480

gagacaaaca ccgatcctct taaggccatc ttcgttgatg acaaggttca gaatgtcatt      540

gttgccagat cctttggaat gacaggcatt gtcttcaagg acactaagag cactaccaag      600

gagctgaaga atctccttgg tgaccccgtc aagagagggg agcacttcct ctcagctcat      660

gccaaacaat tggagtctgt ctgtggggat ggcaccactt tccttgacaa cttcgcccag      720

ctgctgattc ttcatgatac tggaaacagc gatcttgtgg ctcgtcagca ccatggcaga      780

acctggaact acttcattgg caagccgatg gggacgacag acacattccc caacgaccta      840

gataccacct ccatcgctct gctgactctg aatgtagact cagaagtagc gaggtctgtg      900

ttagatgaga tgctgctgta caccagcagt gatgggctgg tagaggtgta ttttgacaaa      960

actagacctc gggtggatcc cgttgtctgt gtcaacgtgc tacgtctctt ctctaaatat     1020

gggagggagc tccagcttca gaagactctg gactgggtaa ctgaggtcct tgttcaccga     1080

gcttacattg acggcacact cttctactac cacgctgaga gcttcttgta cttcctttcg     1140

tgtctctaca aagagaaccc ccggctgcag actcaatttc gggagcctct acaagaacgc     1200

ctgcgggaga ggattgggca gcccggggat gcactttgtc tggctatgcg tgcaatcgca     1260

tgccagactg tggggattgg gaatgttatt gatgtgcaag ctcttctgcc attgcaatct     1320

agtgatggtg gttgggaggc tggctgggtc tgcagaatgg gcacgtctgg tgttcctgtt     1380

ggaaaccgag gagtcacaac ggcactttgt attagagcta ttcgaggcgc atcagggagc     1440

taccacactt ga                                                         1452


<210>  8
<211>  1452
<212>  DNA
<213>  Bazzania sp.


<220>
<221>  misc_feature
<223>  BazzHAD3_E. coli optimized

<400>  8
atgccggcgc tgagcagcca catggaaccg ccgaacttcg acaccctgat tctggacctg       60

ggtgatgtgc tggttggtgg cagcctgcag ggtagctacg cgctggcgat gaagcgtatc      120

ctgaaactga gcctgcgtac cccgacctgg ggcaagtacg aatgcggcca gctgagcgag      180

ctggactgct atgatgcggt tgcggaagac ctgggtaaca gcaccagcag cgcgcaagtg      240

ggcgaggtgg ttagcgaagc gcgtaaaagc ctgcaggtta acgaggatct gatcaaggtg      300

ctgcaagagc tgaaagcgga aaacaacctg cgtgtgtacg ttatgagcaa cattccgaag      360

ccggacctgg cggtggttaa ggcgaaaagc gtgaactggg gtgttatcga tggctggtat      420

ccgagctatg cggttggttt ccacaaaccg gacctggcgt tttatcgtca cgtgctggag      480

gaaaccaaca ccgatccgct gaaggcgatc ttcgtggacg ataaagttca gaacgtgatt      540

gttgcgcgta gcttcggtat gaccggcatc gtttttaagg acaccaaaag caccaccaag      600

gaactgaaaa acctgctggg tgatccggtt aagcgtggcg aacactttct gagcgcgcac      660

gcgaaacaac tggagagcgt gtgcggtgac ggcaccacct tcctggataa ctttgcgcag      720

ctgctgattc tgcacgacac cggtaacagc gatctggtgg cgcgtcaaca ccacggccgt      780

acctggaact acttcattgg caagccgatg ggcaccaccg atacctttcc gaacgacctg      840

gataccacca gcatcgcgct gctgaccctg aacgtggaca gcgaagttgc gcgtagcgtg      900

ctggatgaga tgctgctgta caccagcagc gacggtctgg ttgaggtgta tttcgacaaa      960

acccgtccgc gtgttgatcc ggtggtttgc gtgaacgttc tgcgtctgtt tagcaagtac     1020

ggtcgtgaac tgcagctgca aaaaaccctg gattgggtga ccgaggtgct ggttcaccgt     1080

gcgtatatcg acggcaccct gttctactat cacgcggaaa gcttcctgta ctttctgagc     1140

tgcctgtata aggagaaccc gcgtctgcag acccaatttc gtgagccgct gcaggaacgt     1200

ctgcgtgagc gtattggtca gccgggtgat gcgctgtgcc tggcgatgcg tgcgatcgcg     1260

tgccagaccg ttggtatcgg caacgtgatt gatgttcaag cgctgctgcc gctgcagagc     1320

agcgatggtg gctgggaggc gggttgggtt tgccgtatgg gcaccagcgg tgtgccggtt     1380

ggtaaccgtg gcgtgaccac cgcgctgtgc atccgtgcga ttcgtggtgc gagcggcagc     1440

tatcacacct aa                                                         1452


<210>  9
<211>  483
<212>  PRT
<213>  Bazzania sp.


<220>
<221>  MISC_FEATURE
<223>  BazzHAD3_amino acid sequence

<400>  9

Met Pro Ala Leu Ser Ser His Met Glu Pro Pro Asn Phe Asp Thr Leu 
1               5                   10                  15      


Ile Leu Asp Leu Gly Asp Val Leu Val Gly Gly Ser Leu Gln Gly Ser 
            20                  25                  30          


Tyr Ala Leu Ala Met Lys Arg Ile Leu Lys Leu Ser Leu Arg Thr Pro 
        35                  40                  45              


Thr Trp Gly Lys Tyr Glu Cys Gly Gln Leu Ser Glu Leu Asp Cys Tyr 
    50                  55                  60                  


Asp Ala Val Ala Glu Asp Leu Gly Asn Ser Thr Ser Ser Ala Gln Val 
65                  70                  75                  80  


Gly Glu Val Val Ser Glu Ala Arg Lys Ser Leu Gln Val Asn Glu Asp 
                85                  90                  95      


Leu Ile Lys Val Leu Gln Glu Leu Lys Ala Glu Asn Asn Leu Arg Val 
            100                 105                 110         


Tyr Val Met Ser Asn Ile Pro Lys Pro Asp Leu Ala Val Val Lys Ala 
        115                 120                 125             


Lys Ser Val Asn Trp Gly Val Ile Asp Gly Trp Tyr Pro Ser Tyr Ala 
    130                 135                 140                 


Val Gly Phe His Lys Pro Asp Leu Ala Phe Tyr Arg His Val Leu Glu 
145                 150                 155                 160 


Glu Thr Asn Thr Asp Pro Leu Lys Ala Ile Phe Val Asp Asp Lys Val 
                165                 170                 175     


Gln Asn Val Ile Val Ala Arg Ser Phe Gly Met Thr Gly Ile Val Phe 
            180                 185                 190         


Lys Asp Thr Lys Ser Thr Thr Lys Glu Leu Lys Asn Leu Leu Gly Asp 
        195                 200                 205             


Pro Val Lys Arg Gly Glu His Phe Leu Ser Ala His Ala Lys Gln Leu 
    210                 215                 220                 


Glu Ser Val Cys Gly Asp Gly Thr Thr Phe Leu Asp Asn Phe Ala Gln 
225                 230                 235                 240 


Leu Leu Ile Leu His Asp Thr Gly Asn Ser Asp Leu Val Ala Arg Gln 
                245                 250                 255     


His His Gly Arg Thr Trp Asn Tyr Phe Ile Gly Lys Pro Met Gly Thr 
            260                 265                 270         


Thr Asp Thr Phe Pro Asn Asp Leu Asp Thr Thr Ser Ile Ala Leu Leu 
        275                 280                 285             


Thr Leu Asn Val Asp Ser Glu Val Ala Arg Ser Val Leu Asp Glu Met 
    290                 295                 300                 


Leu Leu Tyr Thr Ser Ser Asp Gly Leu Val Glu Val Tyr Phe Asp Lys 
305                 310                 315                 320 


Thr Arg Pro Arg Val Asp Pro Val Val Cys Val Asn Val Leu Arg Leu 
                325                 330                 335     


Phe Ser Lys Tyr Gly Arg Glu Leu Gln Leu Gln Lys Thr Leu Asp Trp 
            340                 345                 350         


Val Thr Glu Val Leu Val His Arg Ala Tyr Ile Asp Gly Thr Leu Phe 
        355                 360                 365             


Tyr Tyr His Ala Glu Ser Phe Leu Tyr Phe Leu Ser Cys Leu Tyr Lys 
    370                 375                 380                 


Glu Asn Pro Arg Leu Gln Thr Gln Phe Arg Glu Pro Leu Gln Glu Arg 
385                 390                 395                 400 


Leu Arg Glu Arg Ile Gly Gln Pro Gly Asp Ala Leu Cys Leu Ala Met 
                405                 410                 415     


Arg Ala Ile Ala Cys Gln Thr Val Gly Ile Gly Asn Val Ile Asp Val 
            420                 425                 430         


Gln Ala Leu Leu Pro Leu Gln Ser Ser Asp Gly Gly Trp Glu Ala Gly 
        435                 440                 445             


Trp Val Cys Arg Met Gly Thr Ser Gly Val Pro Val Gly Asn Arg Gly 
    450                 455                 460                 


Val Thr Thr Ala Leu Cys Ile Arg Ala Ile Arg Gly Ala Ser Gly Ser 
465                 470                 475                 480 


Tyr His Thr 
            


<210>  10
<211>  1596
<212>  DNA
<213>  Bazzania trilobata


<220>
<221>  misc_feature
<223>  BtHAD_wt_nucleic acid sequence

<400>  10
atggctcctc ctttcggata tattggtggg aatgaatcga gtgtgacgac gtccccagac       60

gtcctcgact acagctatga tggtggccct cctactggcc aatacaagag tatgatttta      120

gacattggcg gagtgttgct tcagcccaac cttgacagga gctatggcac gattgtacca      180

cctgtgcaat tcaaacgtat gttgcgctcg cacatctggt tcaattactc aatgggaaag      240

gtgtctgcgg aggaagtgtt tcggcagctc tccgtgaagt ctggctaccc ggcagaagat      300

atccggagtt ttgctcgaaa agcgagagag tctcttgtgc ccatcacaca aataacggat      360

cttctggtca aactcagcaa ggaatcgaag atcagactgt tctgtatgac caattgccct      420

gccgaagact tcgcatacct ctcacaggca tatcccaacc ttttcggatt gttcgagagg      480

atttttacgt cggcgtccac cggtatgcgc aagccaaaca ggaatttctt ccgacatgta      540

ctccaggaga cgggaatcag tgcgacggag actattttcg tagacgacct ggtaccgaac      600

atcatggccg ccgaggcgct ggacttcacg gcaattcacg tttctccaga gtcgcccgcc      660

gagaccgtga ggttgctgat gttccatctc cgtaagccag aagagcggct ggcggcggcg      720

cgcgactatc tcctgcgcaa ccgtggagtg gacaaagctc tctctctcac atctgacgga      780

gtccgagtcc aggtttattt cgaccacttc gtggtcgccg aagtgctcaa cgacgagcga      840

ttcttgccaa tcactgcagc tccgaagtcc gggactatga actttttccc gaaggaggaa      900

cgcaacgcga ctcgagatat gacgaccaat gcagtcacac acgtggacct tcccgatgat      960

cttgactcca cctctgtcgc cttatcggtc ctttacaaat tctccaaagt ggcgatggag     1020

acggttcaga gggtcctgga tatgatggag aaacgtgtgg acgatgacgg catttttcaa     1080

acgtacttcg atcctttgcg gctgcgtgtt gacccggtgg ccgctactaa caccgtctac     1140

ctcttccatt taggaggtcg tcccggacct actcagcaga cggaacaatt cctctccaag     1200

ttactggaaa agagatctta cgtccgcggc acactctact acaggacccc cgaggcattt     1260

ctctatcaac tcaccagatt ggtggtatca tttgagtatt tcagaaagac aggcttcctg     1320

gaaatgctca agaaaaggct gagtgagcga gtgggcatcg agagcgatgc attcacgttg     1380

gcgatgagga ttctagcgtg tgtgaattgt ggaatccctg ttgctgagct gaacagagat     1440

atggacagac tagcacggat gcaaaatgtg gatggttcat gggacgtctg cccttactac     1500

agctacaatg atcccaagag ttggtttggc aacgagcttc ttaccacagc gtttgctgct     1560

gccgctcttg agcattctga gcccaacttt aagtga                               1596


<210>  11
<211>  1596
<212>  DNA
<213>  Bazzania trilobata


<220>
<221>  misc_feature
<223>  BtHAD_E. coli optimized

<400>  11
atggctccgc cgttcggtta cattggtggc aacgagagca gcgttaccac cagcccggat       60

gtgctggact acagctatga tggtggcccg ccgaccggcc agtacaaaag catgatcctg      120

gatattggtg gcgttctgct gcaaccgaac ctggaccgta gctatggcac catcgttccg      180

ccggtgcagt tcaagcgtat gctgcgtagc cacatttggt ttaactacag catgggtaaa      240

gttagcgcgg aggaagtgtt ccgtcaactg agcgtgaaga gcggctatcc ggcggaggat      300

atccgtagct ttgcgcgtaa agcgcgtgaa agcctggttc cgatcaccca gattaccgac      360

ctgctggtga agctgagcaa agagagcaag attcgtctgt tctgcatgac caactgcccg      420

gcggaagact ttgcgtacct gagccaagcg tatccgaacc tgttcggtct gtttgagcgt      480

atcttcacca gcgcgagcac cggcatgcgt aagccgaacc gtaacttctt tcgtcacgtt      540

ctgcaggaga ccggcatcag cgcgaccgaa accattttcg ttgacgatct ggtgccgaac      600

atcatggcgg cggaagcgct ggattttacc gcgattcacg ttagcccgga gagcccggcg      660

gaaaccgtgc gtctgctgat gtttcacctg cgtaaaccgg aggaacgtct ggcggcggcg      720

cgtgactacc tgctgcgtaa ccgtggtgtt gataaagcgc tgagcctgac cagcgatggt      780

gtgcgtgttc aagtgtattt cgatcacttt gtggttgcgg aagtgctgaa cgacgaacgt      840

ttcctgccga ttaccgcggc gccgaaaagc ggcaccatga acttctttcc gaaagaggag      900

cgtaacgcga cccgtgatat gaccaccaac gcggttaccc acgtggatct gccggacgat      960

ctggacagca ccagcgttgc gctgagcgtg ctgtacaaat ttagcaaggt tgcgatggag     1020

accgttcagc gtgtgctgga catgatggaa aaacgtgtgg acgatgacgg catcttccaa     1080

acctactttg atccgctgcg tctgcgtgtt gacccggtgg cggcgaccaa caccgtttac     1140

ctgttccatc tgggtggccg tccgggtccg acccagcaaa ccgagcagtt tctgagcaaa     1200

ctgctggaaa agcgtagcta tgtgcgtggc accctgtact atcgtacccc ggaagcgttc     1260

ctgtaccaac tgacccgtct ggtggttagc ttcgagtatt ttcgtaagac cggttttctg     1320

gaaatgctga agaaacgtct gagcgagcgt gtgggcatcg aaagcgatgc gttcaccctg     1380

gcgatgcgta tcctggcgtg cgttaactgc ggtattccgg tggcggagct gaaccgtgat     1440

atggaccgtc tggcgcgtat gcagaacgtt gatggtagct gggacgtgtg cccgtactat     1500

agctacaacg acccgaaaag ctggttcggc aacgaactgc tgaccaccgc gtttgcggcg     1560

gcggcgctgg agcacagcga accgaacttc aagtaa                               1596


<210>  12
<211>  531
<212>  PRT
<213>  Bazzania trilobata


<220>
<221>  MISC_FEATURE
<223>  BtHAD_amino acid sequence

<400>  12

Met Ala Pro Pro Phe Gly Tyr Ile Gly Gly Asn Glu Ser Ser Val Thr 
1               5                   10                  15      


Thr Ser Pro Asp Val Leu Asp Tyr Ser Tyr Asp Gly Gly Pro Pro Thr 
            20                  25                  30          


Gly Gln Tyr Lys Ser Met Ile Leu Asp Ile Gly Gly Val Leu Leu Gln 
        35                  40                  45              


Pro Asn Leu Asp Arg Ser Tyr Gly Thr Ile Val Pro Pro Val Gln Phe 
    50                  55                  60                  


Lys Arg Met Leu Arg Ser His Ile Trp Phe Asn Tyr Ser Met Gly Lys 
65                  70                  75                  80  


Val Ser Ala Glu Glu Val Phe Arg Gln Leu Ser Val Lys Ser Gly Tyr 
                85                  90                  95      


Pro Ala Glu Asp Ile Arg Ser Phe Ala Arg Lys Ala Arg Glu Ser Leu 
            100                 105                 110         


Val Pro Ile Thr Gln Ile Thr Asp Leu Leu Val Lys Leu Ser Lys Glu 
        115                 120                 125             


Ser Lys Ile Arg Leu Phe Cys Met Thr Asn Cys Pro Ala Glu Asp Phe 
    130                 135                 140                 


Ala Tyr Leu Ser Gln Ala Tyr Pro Asn Leu Phe Gly Leu Phe Glu Arg 
145                 150                 155                 160 


Ile Phe Thr Ser Ala Ser Thr Gly Met Arg Lys Pro Asn Arg Asn Phe 
                165                 170                 175     


Phe Arg His Val Leu Gln Glu Thr Gly Ile Ser Ala Thr Glu Thr Ile 
            180                 185                 190         


Phe Val Asp Asp Leu Val Pro Asn Ile Met Ala Ala Glu Ala Leu Asp 
        195                 200                 205             


Phe Thr Ala Ile His Val Ser Pro Glu Ser Pro Ala Glu Thr Val Arg 
    210                 215                 220                 


Leu Leu Met Phe His Leu Arg Lys Pro Glu Glu Arg Leu Ala Ala Ala 
225                 230                 235                 240 


Arg Asp Tyr Leu Leu Arg Asn Arg Gly Val Asp Lys Ala Leu Ser Leu 
                245                 250                 255     


Thr Ser Asp Gly Val Arg Val Gln Val Tyr Phe Asp His Phe Val Val 
            260                 265                 270         


Ala Glu Val Leu Asn Asp Glu Arg Phe Leu Pro Ile Thr Ala Ala Pro 
        275                 280                 285             


Lys Ser Gly Thr Met Asn Phe Phe Pro Lys Glu Glu Arg Asn Ala Thr 
    290                 295                 300                 


Arg Asp Met Thr Thr Asn Ala Val Thr His Val Asp Leu Pro Asp Asp 
305                 310                 315                 320 


Leu Asp Ser Thr Ser Val Ala Leu Ser Val Leu Tyr Lys Phe Ser Lys 
                325                 330                 335     


Val Ala Met Glu Thr Val Gln Arg Val Leu Asp Met Met Glu Lys Arg 
            340                 345                 350         


Val Asp Asp Asp Gly Ile Phe Gln Thr Tyr Phe Asp Pro Leu Arg Leu 
        355                 360                 365             


Arg Val Asp Pro Val Ala Ala Thr Asn Thr Val Tyr Leu Phe His Leu 
    370                 375                 380                 


Gly Gly Arg Pro Gly Pro Thr Gln Gln Thr Glu Gln Phe Leu Ser Lys 
385                 390                 395                 400 


Leu Leu Glu Lys Arg Ser Tyr Val Arg Gly Thr Leu Tyr Tyr Arg Thr 
                405                 410                 415     


Pro Glu Ala Phe Leu Tyr Gln Leu Thr Arg Leu Val Val Ser Phe Glu 
            420                 425                 430         


Tyr Phe Arg Lys Thr Gly Phe Leu Glu Met Leu Lys Lys Arg Leu Ser 
        435                 440                 445             


Glu Arg Val Gly Ile Glu Ser Asp Ala Phe Thr Leu Ala Met Arg Ile 
    450                 455                 460                 


Leu Ala Cys Val Asn Cys Gly Ile Pro Val Ala Glu Leu Asn Arg Asp 
465                 470                 475                 480 


Met Asp Arg Leu Ala Arg Met Gln Asn Val Asp Gly Ser Trp Asp Val 
                485                 490                 495     


Cys Pro Tyr Tyr Ser Tyr Asn Asp Pro Lys Ser Trp Phe Gly Asn Glu 
            500                 505                 510         


Leu Leu Thr Thr Ala Phe Ala Ala Ala Ala Leu Glu His Ser Glu Pro 
        515                 520                 525             


Asn Phe Lys 
    530     


<210>  13
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BtHAD mutant of class II motif_E. coli optimized

<400>  13
atggctccgc cgttcggtta cattggtggc aacgagagca gcgttaccac cagcccggat       60

gtgctggact acagctatga tggtggcccg ccgaccggcc agtacaaaag catgatcctg      120

gatattggtg gcgttctgct gcaaccgaac ctggaccgta gctatggcac catcgttccg      180

ccggtgcagt tcaagcgtat gctgcgtagc cacatttggt ttaactacag catgggtaaa      240

gttagcgcgg aggaagtgtt ccgtcaactg agcgtgaaga gcggctatcc ggcggaggat      300

atccgtagct ttgcgcgtaa agcgcgtgaa agcctggttc cgatcaccca gattaccgac      360

ctgctggtga agctgagcaa agagagcaag attcgtctgt tctgcatgac caactgcccg      420

gcggaagact ttgcgtacct gagccaagcg tatccgaacc tgttcggtct gtttgagcgt      480

atcttcacca gcgcgagcac cggcatgcgt aagccgaacc gtaacttctt tcgtcacgtt      540

ctgcaggaga ccggcatcag cgcgaccgaa accattttcg ttgacgatct ggtgccgaac      600

atcatggcgg cggaagcgct ggattttacc gcgattcacg ttagcccgga gagcccggcg      660

gaaaccgtgc gtctgctgat gtttcacctg cgtaaaccgg aggaacgtct ggcggcggcg      720

cgtgactacc tgctgcgtaa ccgtggtgtt gataaagcgc tgagcctgac cagcgatggt      780

gtgcgtgttc aagtgtattt cgatcacttt gtggttgcgg aagtgctgaa cgacgaacgt      840

ttcctgccga ttaccgcggc gccgaaaagc ggcaccatga acttctttcc gaaagaggag      900

cgtaacgcga cccgtgatat gaccaccaac gcggttaccc acgtggatct gccggacgcg      960

ctggcgagca ccagcgttgc gctgagcgtg ctgtacaaat ttagcaaggt tgcgatggag     1020

accgttcagc gtgtgctgga catgatggaa aaacgtgtgg acgatgacgg catcttccaa     1080

acctactttg atccgctgcg tctgcgtgtt gacccggtgg cggcgaccaa caccgtttac     1140

ctgttccatc tgggtggccg tccgggtccg acccagcaaa ccgagcagtt tctgagcaaa     1200

ctgctggaaa agcgtagcta tgtgcgtggc accctgtact atcgtacccc ggaagcgttc     1260

ctgtaccaac tgacccgtct ggtggttagc ttcgagtatt ttcgtaagac cggttttctg     1320

gaaatgctga agaaacgtct gagcgagcgt gtgggcatcg aaagcgatgc gttcaccctg     1380

gcgatgcgta tcctggcgtg cgttaactgc ggtattccgg tggcggagct gaaccgtgat     1440

atggaccgtc tggcgcgtat gcagaacgtt gatggtagct gggacgtgtg cccgtactat     1500

agctacaacg acccgaaaag ctggttcggc aacgaactgc tgaccaccgc gtttgcggcg     1560

gcggcgctgg agcacagcga accgaacttc aagtaa                               1596


<210>  14
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BtHAD mutant of class II motif

<400>  14

Met Ala Pro Pro Phe Gly Tyr Ile Gly Gly Asn Glu Ser Ser Val Thr 
1               5                   10                  15      


Thr Ser Pro Asp Val Leu Asp Tyr Ser Tyr Asp Gly Gly Pro Pro Thr 
            20                  25                  30          


Gly Gln Tyr Lys Ser Met Ile Leu Asp Ile Gly Gly Val Leu Leu Gln 
        35                  40                  45              


Pro Asn Leu Asp Arg Ser Tyr Gly Thr Ile Val Pro Pro Val Gln Phe 
    50                  55                  60                  


Lys Arg Met Leu Arg Ser His Ile Trp Phe Asn Tyr Ser Met Gly Lys 
65                  70                  75                  80  


Val Ser Ala Glu Glu Val Phe Arg Gln Leu Ser Val Lys Ser Gly Tyr 
                85                  90                  95      


Pro Ala Glu Asp Ile Arg Ser Phe Ala Arg Lys Ala Arg Glu Ser Leu 
            100                 105                 110         


Val Pro Ile Thr Gln Ile Thr Asp Leu Leu Val Lys Leu Ser Lys Glu 
        115                 120                 125             


Ser Lys Ile Arg Leu Phe Cys Met Thr Asn Cys Pro Ala Glu Asp Phe 
    130                 135                 140                 


Ala Tyr Leu Ser Gln Ala Tyr Pro Asn Leu Phe Gly Leu Phe Glu Arg 
145                 150                 155                 160 


Ile Phe Thr Ser Ala Ser Thr Gly Met Arg Lys Pro Asn Arg Asn Phe 
                165                 170                 175     


Phe Arg His Val Leu Gln Glu Thr Gly Ile Ser Ala Thr Glu Thr Ile 
            180                 185                 190         


Phe Val Asp Asp Leu Val Pro Asn Ile Met Ala Ala Glu Ala Leu Asp 
        195                 200                 205             


Phe Thr Ala Ile His Val Ser Pro Glu Ser Pro Ala Glu Thr Val Arg 
    210                 215                 220                 


Leu Leu Met Phe His Leu Arg Lys Pro Glu Glu Arg Leu Ala Ala Ala 
225                 230                 235                 240 


Arg Asp Tyr Leu Leu Arg Asn Arg Gly Val Asp Lys Ala Leu Ser Leu 
                245                 250                 255     


Thr Ser Asp Gly Val Arg Val Gln Val Tyr Phe Asp His Phe Val Val 
            260                 265                 270         


Ala Glu Val Leu Asn Asp Glu Arg Phe Leu Pro Ile Thr Ala Ala Pro 
        275                 280                 285             


Lys Ser Gly Thr Met Asn Phe Phe Pro Lys Glu Glu Arg Asn Ala Thr 
    290                 295                 300                 


Arg Asp Met Thr Thr Asn Ala Val Thr His Val Asp Leu Pro Asp Ala 
305                 310                 315                 320 


Leu Ala Ser Thr Ser Val Ala Leu Ser Val Leu Tyr Lys Phe Ser Lys 
                325                 330                 335     


Val Ala Met Glu Thr Val Gln Arg Val Leu Asp Met Met Glu Lys Arg 
            340                 345                 350         


Val Asp Asp Asp Gly Ile Phe Gln Thr Tyr Phe Asp Pro Leu Arg Leu 
        355                 360                 365             


Arg Val Asp Pro Val Ala Ala Thr Asn Thr Val Tyr Leu Phe His Leu 
    370                 375                 380                 


Gly Gly Arg Pro Gly Pro Thr Gln Gln Thr Glu Gln Phe Leu Ser Lys 
385                 390                 395                 400 


Leu Leu Glu Lys Arg Ser Tyr Val Arg Gly Thr Leu Tyr Tyr Arg Thr 
                405                 410                 415     


Pro Glu Ala Phe Leu Tyr Gln Leu Thr Arg Leu Val Val Ser Phe Glu 
            420                 425                 430         


Tyr Phe Arg Lys Thr Gly Phe Leu Glu Met Leu Lys Lys Arg Leu Ser 
        435                 440                 445             


Glu Arg Val Gly Ile Glu Ser Asp Ala Phe Thr Leu Ala Met Arg Ile 
    450                 455                 460                 


Leu Ala Cys Val Asn Cys Gly Ile Pro Val Ala Glu Leu Asn Arg Asp 
465                 470                 475                 480 


Met Asp Arg Leu Ala Arg Met Gln Asn Val Asp Gly Ser Trp Asp Val 
                485                 490                 495     


Cys Pro Tyr Tyr Ser Tyr Asn Asp Pro Lys Ser Trp Phe Gly Asn Glu 
            500                 505                 510         


Leu Leu Thr Thr Ala Phe Ala Ala Ala Ala Leu Glu His Ser Glu Pro 
        515                 520                 525             


Asn Phe Lys 
    530     


<210>  15
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BtHAD mutant of QW motif_E. coli optimized

<400>  15
atggctccgc cgttcggtta cattggtggc aacgagagca gcgttaccac cagcccggat       60

gtgctggact acagctatga tggtggcccg ccgaccggcc agtacaaaag catgatcctg      120

gatattggtg gcgttctgct gcaaccgaac ctggaccgta gctatggcac catcgttccg      180

ccggtgcagt tcaagcgtat gctgcgtagc cacatttggt ttaactacag catgggtaaa      240

gttagcgcgg aggaagtgtt ccgtcaactg agcgtgaaga gcggctatcc ggcggaggat      300

atccgtagct ttgcgcgtaa agcgcgtgaa agcctggttc cgatcaccca gattaccgac      360

ctgctggtga agctgagcaa agagagcaag attcgtctgt tctgcatgac caactgcccg      420

gcggaagact ttgcgtacct gagccaagcg tatccgaacc tgttcggtct gtttgagcgt      480

atcttcacca gcgcgagcac cggcatgcgt aagccgaacc gtaacttctt tcgtcacgtt      540

ctgcaggaga ccggcatcag cgcgaccgaa accattttcg ttgacgatct ggtgccgaac      600

atcatggcgg cggaagcgct ggattttacc gcgattcacg ttagcccgga gagcccggcg      660

gaaaccgtgc gtctgctgat gtttcacctg cgtaaaccgg aggaacgtct ggcggcggcg      720

cgtgactacc tgctgcgtaa ccgtggtgtt gataaagcgc tgagcctgac cagcgatggt      780

gtgcgtgttc aagtgtattt cgatcacttt gtggttgcgg aagtgctgaa cgacgaacgt      840

ttcctgccga ttaccgcggc gccgaaaagc ggcaccatga acttctttcc gaaagaggag      900

cgtaacgcga cccgtgatat gaccaccaac gcggttaccc acgtggatct gccggacgat      960

ctggacagca ccagcgttgc gctgagcgtg ctgtacaaat ttagcaaggt tgcgatggag     1020

accgttcagc gtgtgctgga catgatggaa aaacgtgtgg acgatgacgg catcttccaa     1080

acctactttg atccgctgcg tctgcgtgtt gacccggtgg cggcgaccaa caccgtttac     1140

ctgttccatc tgggtggccg tccgggtccg acccagcaaa ccgagcagtt tctgagcaaa     1200

ctgctggaaa agcgtagcta tgtgcgtggc accctgtact atcgtacccc ggaagcgttc     1260

ctgtaccaac tgacccgtct ggtggttagc ttcgagtatt ttcgtaagac cggttttctg     1320

gaaatgctga agaaacgtct gagcgagcgt gtgggcatcg aaagcgatgc gttcaccctg     1380

gcgatgcgta tcctggcgtg cgttaactgc ggtattccgg tggcggagct gaaccgtgat     1440

atggaccgtc tggcgcgtat gcagaacgtt gcgggtagct gggacgtgtg cccgtactat     1500

agctacaacg acccgaaaag ctggttcggc aacgaactgc tgaccaccgc gtttgcggcg     1560

gcggcgctgg agcacagcga accgaacttc aagtaa                               1596


<210>  16
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BtHAD mutant of QW motif

<400>  16

Met Ala Pro Pro Phe Gly Tyr Ile Gly Gly Asn Glu Ser Ser Val Thr 
1               5                   10                  15      


Thr Ser Pro Asp Val Leu Asp Tyr Ser Tyr Asp Gly Gly Pro Pro Thr 
            20                  25                  30          


Gly Gln Tyr Lys Ser Met Ile Leu Asp Ile Gly Gly Val Leu Leu Gln 
        35                  40                  45              


Pro Asn Leu Asp Arg Ser Tyr Gly Thr Ile Val Pro Pro Val Gln Phe 
    50                  55                  60                  


Lys Arg Met Leu Arg Ser His Ile Trp Phe Asn Tyr Ser Met Gly Lys 
65                  70                  75                  80  


Val Ser Ala Glu Glu Val Phe Arg Gln Leu Ser Val Lys Ser Gly Tyr 
                85                  90                  95      


Pro Ala Glu Asp Ile Arg Ser Phe Ala Arg Lys Ala Arg Glu Ser Leu 
            100                 105                 110         


Val Pro Ile Thr Gln Ile Thr Asp Leu Leu Val Lys Leu Ser Lys Glu 
        115                 120                 125             


Ser Lys Ile Arg Leu Phe Cys Met Thr Asn Cys Pro Ala Glu Asp Phe 
    130                 135                 140                 


Ala Tyr Leu Ser Gln Ala Tyr Pro Asn Leu Phe Gly Leu Phe Glu Arg 
145                 150                 155                 160 


Ile Phe Thr Ser Ala Ser Thr Gly Met Arg Lys Pro Asn Arg Asn Phe 
                165                 170                 175     


Phe Arg His Val Leu Gln Glu Thr Gly Ile Ser Ala Thr Glu Thr Ile 
            180                 185                 190         


Phe Val Asp Asp Leu Val Pro Asn Ile Met Ala Ala Glu Ala Leu Asp 
        195                 200                 205             


Phe Thr Ala Ile His Val Ser Pro Glu Ser Pro Ala Glu Thr Val Arg 
    210                 215                 220                 


Leu Leu Met Phe His Leu Arg Lys Pro Glu Glu Arg Leu Ala Ala Ala 
225                 230                 235                 240 


Arg Asp Tyr Leu Leu Arg Asn Arg Gly Val Asp Lys Ala Leu Ser Leu 
                245                 250                 255     


Thr Ser Asp Gly Val Arg Val Gln Val Tyr Phe Asp His Phe Val Val 
            260                 265                 270         


Ala Glu Val Leu Asn Asp Glu Arg Phe Leu Pro Ile Thr Ala Ala Pro 
        275                 280                 285             


Lys Ser Gly Thr Met Asn Phe Phe Pro Lys Glu Glu Arg Asn Ala Thr 
    290                 295                 300                 


Arg Asp Met Thr Thr Asn Ala Val Thr His Val Asp Leu Pro Asp Asp 
305                 310                 315                 320 


Leu Asp Ser Thr Ser Val Ala Leu Ser Val Leu Tyr Lys Phe Ser Lys 
                325                 330                 335     


Val Ala Met Glu Thr Val Gln Arg Val Leu Asp Met Met Glu Lys Arg 
            340                 345                 350         


Val Asp Asp Asp Gly Ile Phe Gln Thr Tyr Phe Asp Pro Leu Arg Leu 
        355                 360                 365             


Arg Val Asp Pro Val Ala Ala Thr Asn Thr Val Tyr Leu Phe His Leu 
    370                 375                 380                 


Gly Gly Arg Pro Gly Pro Thr Gln Gln Thr Glu Gln Phe Leu Ser Lys 
385                 390                 395                 400 


Leu Leu Glu Lys Arg Ser Tyr Val Arg Gly Thr Leu Tyr Tyr Arg Thr 
                405                 410                 415     


Pro Glu Ala Phe Leu Tyr Gln Leu Thr Arg Leu Val Val Ser Phe Glu 
            420                 425                 430         


Tyr Phe Arg Lys Thr Gly Phe Leu Glu Met Leu Lys Lys Arg Leu Ser 
        435                 440                 445             


Glu Arg Val Gly Ile Glu Ser Asp Ala Phe Thr Leu Ala Met Arg Ile 
    450                 455                 460                 


Leu Ala Cys Val Asn Cys Gly Ile Pro Val Ala Glu Leu Asn Arg Asp 
465                 470                 475                 480 


Met Asp Arg Leu Ala Arg Met Gln Asn Val Ala Gly Ser Trp Asp Val 
                485                 490                 495     


Cys Pro Tyr Tyr Ser Tyr Asn Asp Pro Lys Ser Trp Phe Gly Asn Glu 
            500                 505                 510         


Leu Leu Thr Thr Ala Phe Ala Ala Ala Ala Leu Glu His Ser Glu Pro 
        515                 520                 525             


Asn Phe Lys 
    530     


<210>  17
<211>  1410
<212>  DNA
<213>  Selaginella moellendorffii


<220>
<221>  misc_feature
<223>  SmHAD1_wt_nucleic acid sequence

<400>  17
atgataatca ttagctttgc ttgcttgctc aagtttggat gtggagacaa tggcccccgg       60

ggagatctcc tccgcagggc tctccagcac tcctccttct tggcctattc ttgcggggag      120

ctcgatcgca ctgccgcaat ctcgacaatc tcgcgcaaat tcaagctcac ggacccagct      180

ctcgtggatt ccatgctgct cgaggccgct tccagctgcg aggtggacaa ggagctactg      240

tcactgctcc agtcaacgag gcagcagctc ctgggatgga ttgatattcc tccacaagag      300

tgggagcgag tttacagcct cttcccggtg tcgctctgga agaacttcgc tacaatctcc      360

cgcgatctag attccctcct tggagatatc aggtcccatg ctgtgattgt cgataaaagc      420

gtggagatgg ccgcgctaca tgccttcgag agcttgctcg ctctcccgta tgcctcgccc      480

aacaagaaag cttgccagga cttcttgaag cgtcggttcc tgctgcctcg agctgtgaag      540

ctggggatgg atcgagtcaa ggaggaggtg agatccaagc agctcaaatc actctacctg      600

cttgacaatg gccggcacga gctcgtctcc gagatcttct ttccctgcgt ggcggcctgg      660

tgccttccgg agatcattcc tctcggctgg atgaaatatc tccaggtact gatcaagcgc      720

ggccatccct tcggttactt cggtgccgac gtctcgcgct atccgccgga catcgacacc      780

atgtcgactt gtgtctccac actttttgat cttagtctcg tcacctccgc gcaagctatg      840

cactttctgg agatttgtct cgagaacgtc aacgatcaaa accagcttct cacgtacctg      900

gacgtggagc ggcctcgagt ggatccggtc gtcatagcca acgttgtcta tctcgcctat      960

gcgctctcca tggaagatca cccggttgtc cgccacaacg agaatctgat ccagagatat     1020

ctgttaagcg gcggattcgt atacgggact cgctattacc tcagccagga ggacttcttg     1080

ttcatgtatg gccgggtcct cgcgacgttt ggagagaaga gggagattcc caactttgat     1140

ctcgtgtatc aagcgatgga ggcggctctc gtcaaccgga tcgggaacga gaccgagtcg     1200

aagccactgg acgttgccaa aaggattctg ctcagcaggg gttttggaat ccggaacacg     1260

atagatgtag acttgctcct caagatgcag aacgaggatg gttcctggcc tttgcaagtg     1320

ctcagcaatc ttccatctgc taaaggtggt gtcttcaatt cggtggtgga cttgagcttt     1380

gcggtgagag cactgcaaag tcaagattga                                      1410


<210>  18
<211>  1410
<212>  DNA
<213>  Selaginella moellendorffii


<220>
<221>  misc_feature
<223>  SmHAD1_E. coli optimized

<400>  18
atgatcatta tcagcttcgc gtgcctgctg aagtttggtt gcggtgacaa cggtccgcgt       60

ggcgatctgc tgcgtcgtgc gctgcagcac agcagcttcc tggcgtatag ctgcggcgag      120

ctggaccgta ccgcggcgat tagcaccatc agccgtaagt ttaaactgac cgacccggcg      180

ctggttgata gcatgctgct ggaagcggcg agcagctgcg aggtggacaa agaactgctg      240

agcctgctgc agagcacccg tcagcaactg ctgggttgga ttgatatccc gccgcaagag      300

tgggaacgtg tgtacagcct gttcccggtt agcctgtgga agaactttgc gaccattagc      360

cgtgacctgg atagcctgct gggcgacatt cgtagccacg cggtgatcgt tgataaaagc      420

gttgagatgg cggcgctgca cgcgttcgaa agcctgctgg cgctgccgta tgcgagcccg      480

aacaagaaag cgtgccagga cttcctgaag cgtcgttttc tgctgccgcg tgcggtgaag      540

ctgggtatgg atcgtgtgaa agaggaagtt cgtagcaagc aactgaaaag cctgtacctg      600

ctggacaacg gccgtcacga gctggttagc gaaattttct ttccgtgcgt tgcggcgtgg      660

tgcctgccgg agattatccc gctgggttgg atgaagtatc tgcaggttct gattaaacgt      720

ggccacccgt tcggttactt tggtgcggat gtgagccgtt atccgccgga catcgatacc      780

atgagcacct gcgtgagcac cctgttcgat ctgagcctgg ttaccagcgc gcaagcgatg      840

cactttctgg agatctgcct ggaaaacgtt aacgaccaga accaactgct gacctacctg      900

gacgtggaac gtccgcgtgt tgatccggtg gttattgcga acgtggttta cctggcgtat      960

gcgctgagca tggaggatca cccggtggtt cgtcacaacg aaaacctgat ccagcgttac     1020

ctgctgagcg gtggcttcgt ttatggcacc cgttactatc tgagccaaga ggacttcctg     1080

tttatgtacg gtcgtgtgct ggcgaccttc ggcgagaaac gtgaaatccc gaactttgat     1140

ctggtgtatc aggcgatgga agcggcgctg gttaaccgta ttggtaacga gaccgaaagc     1200

aagccgctgg acgttgcgaa acgtatcctg ctgagccgtg gttttggcat tcgtaacacc     1260

atcgacgtgg atctgctgct gaagatgcag aacgaggatg gcagctggcc gctgcaagtg     1320

ctgagcaacc tgccgagcgc gaaaggtggc gttttcaaca gcgtggttga cctgagcttt     1380

gcggtgcgtg cgctgcagag ccaagattaa                                      1410


<210>  19
<211>  469
<212>  PRT
<213>  Selaginella moellendorffii


<220>
<221>  MISC_FEATURE
<223>  SmHAD1_amino acid sequence

<400>  19

Met Ile Ile Ile Ser Phe Ala Cys Leu Leu Lys Phe Gly Cys Gly Asp 
1               5                   10                  15      


Asn Gly Pro Arg Gly Asp Leu Leu Arg Arg Ala Leu Gln His Ser Ser 
            20                  25                  30          


Phe Leu Ala Tyr Ser Cys Gly Glu Leu Asp Arg Thr Ala Ala Ile Ser 
        35                  40                  45              


Thr Ile Ser Arg Lys Phe Lys Leu Thr Asp Pro Ala Leu Val Asp Ser 
    50                  55                  60                  


Met Leu Leu Glu Ala Ala Ser Ser Cys Glu Val Asp Lys Glu Leu Leu 
65                  70                  75                  80  


Ser Leu Leu Gln Ser Thr Arg Gln Gln Leu Leu Gly Trp Ile Asp Ile 
                85                  90                  95      


Pro Pro Gln Glu Trp Glu Arg Val Tyr Ser Leu Phe Pro Val Ser Leu 
            100                 105                 110         


Trp Lys Asn Phe Ala Thr Ile Ser Arg Asp Leu Asp Ser Leu Leu Gly 
        115                 120                 125             


Asp Ile Arg Ser His Ala Val Ile Val Asp Lys Ser Val Glu Met Ala 
    130                 135                 140                 


Ala Leu His Ala Phe Glu Ser Leu Leu Ala Leu Pro Tyr Ala Ser Pro 
145                 150                 155                 160 


Asn Lys Lys Ala Cys Gln Asp Phe Leu Lys Arg Arg Phe Leu Leu Pro 
                165                 170                 175     


Arg Ala Val Lys Leu Gly Met Asp Arg Val Lys Glu Glu Val Arg Ser 
            180                 185                 190         


Lys Gln Leu Lys Ser Leu Tyr Leu Leu Asp Asn Gly Arg His Glu Leu 
        195                 200                 205             


Val Ser Glu Ile Phe Phe Pro Cys Val Ala Ala Trp Cys Leu Pro Glu 
    210                 215                 220                 


Ile Ile Pro Leu Gly Trp Met Lys Tyr Leu Gln Val Leu Ile Lys Arg 
225                 230                 235                 240 


Gly His Pro Phe Gly Tyr Phe Gly Ala Asp Val Ser Arg Tyr Pro Pro 
                245                 250                 255     


Asp Ile Asp Thr Met Ser Thr Cys Val Ser Thr Leu Phe Asp Leu Ser 
            260                 265                 270         


Leu Val Thr Ser Ala Gln Ala Met His Phe Leu Glu Ile Cys Leu Glu 
        275                 280                 285             


Asn Val Asn Asp Gln Asn Gln Leu Leu Thr Tyr Leu Asp Val Glu Arg 
    290                 295                 300                 


Pro Arg Val Asp Pro Val Val Ile Ala Asn Val Val Tyr Leu Ala Tyr 
305                 310                 315                 320 


Ala Leu Ser Met Glu Asp His Pro Val Val Arg His Asn Glu Asn Leu 
                325                 330                 335     


Ile Gln Arg Tyr Leu Leu Ser Gly Gly Phe Val Tyr Gly Thr Arg Tyr 
            340                 345                 350         


Tyr Leu Ser Gln Glu Asp Phe Leu Phe Met Tyr Gly Arg Val Leu Ala 
        355                 360                 365             


Thr Phe Gly Glu Lys Arg Glu Ile Pro Asn Phe Asp Leu Val Tyr Gln 
    370                 375                 380                 


Ala Met Glu Ala Ala Leu Val Asn Arg Ile Gly Asn Glu Thr Glu Ser 
385                 390                 395                 400 


Lys Pro Leu Asp Val Ala Lys Arg Ile Leu Leu Ser Arg Gly Phe Gly 
                405                 410                 415     


Ile Arg Asn Thr Ile Asp Val Asp Leu Leu Leu Lys Met Gln Asn Glu 
            420                 425                 430         


Asp Gly Ser Trp Pro Leu Gln Val Leu Ser Asn Leu Pro Ser Ala Lys 
        435                 440                 445             


Gly Gly Val Phe Asn Ser Val Val Asp Leu Ser Phe Ala Val Arg Ala 
    450                 455                 460                 


Leu Gln Ser Gln Asp 
465                 


<210>  20
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SmHAD1 mutant of class II motif_E. coli optimized

<400>  20
atgatcatta tcagcttcgc gtgcctgctg aagtttggtt gcggtgacaa cggtccgcgt       60

ggcgatctgc tgcgtcgtgc gctgcagcac agcagcttcc tggcgtatag ctgcggcgag      120

ctggaccgta ccgcggcgat tagcaccatc agccgtaagt ttaaactgac cgacccggcg      180

ctggttgata gcatgctgct ggaagcggcg agcagctgcg aggtggacaa agaactgctg      240

agcctgctgc agagcacccg tcagcaactg ctgggttgga ttgatatccc gccgcaagag      300

tgggaacgtg tgtacagcct gttcccggtt agcctgtgga agaactttgc gaccattagc      360

cgtgacctgg atagcctgct gggcgacatt cgtagccacg cggtgatcgt tgataaaagc      420

gttgagatgg cggcgctgca cgcgttcgaa agcctgctgg cgctgccgta tgcgagcccg      480

aacaagaaag cgtgccagga cttcctgaag cgtcgttttc tgctgccgcg tgcggtgaag      540

ctgggtatgg atcgtgtgaa agaggaagtt cgtagcaagc aactgaaaag cctgtacctg      600

ctggacaacg gccgtcacga gctggttagc gaaattttct ttccgtgcgt tgcggcgtgg      660

tgcctgccgg agattatccc gctgggttgg atgaagtatc tgcaggttct gattaaacgt      720

ggccacccgt tcggttactt tggtgcggat gtgagccgtt atccgccggc gatcgcgacc      780

atgagcacct gcgtgagcac cctgttcgat ctgagcctgg ttaccagcgc gcaagcgatg      840

cactttctgg agatctgcct ggaaaacgtt aacgaccaga accaactgct gacctacctg      900

gacgtggaac gtccgcgtgt tgatccggtg gttattgcga acgtggttta cctggcgtat      960

gcgctgagca tggaggatca cccggtggtt cgtcacaacg aaaacctgat ccagcgttac     1020

ctgctgagcg gtggcttcgt ttatggcacc cgttactatc tgagccaaga ggacttcctg     1080

tttatgtacg gtcgtgtgct ggcgaccttc ggcgagaaac gtgaaatccc gaactttgat     1140

ctggtgtatc aggcgatgga agcggcgctg gttaaccgta ttggtaacga gaccgaaagc     1200

aagccgctgg acgttgcgaa acgtatcctg ctgagccgtg gttttggcat tcgtaacacc     1260

atcgacgtgg atctgctgct gaagatgcag aacgaggatg gcagctggcc gctgcaagtg     1320

ctgagcaacc tgccgagcgc gaaaggtggc gttttcaaca gcgtggttga cctgagcttt     1380

gcggtgcgtg cgctgcagag ccaagattaa                                      1410


<210>  21
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SmHAD1 mutant of class II motif

<400>  21

Met Ile Ile Ile Ser Phe Ala Cys Leu Leu Lys Phe Gly Cys Gly Asp 
1               5                   10                  15      


Asn Gly Pro Arg Gly Asp Leu Leu Arg Arg Ala Leu Gln His Ser Ser 
            20                  25                  30          


Phe Leu Ala Tyr Ser Cys Gly Glu Leu Asp Arg Thr Ala Ala Ile Ser 
        35                  40                  45              


Thr Ile Ser Arg Lys Phe Lys Leu Thr Asp Pro Ala Leu Val Asp Ser 
    50                  55                  60                  


Met Leu Leu Glu Ala Ala Ser Ser Cys Glu Val Asp Lys Glu Leu Leu 
65                  70                  75                  80  


Ser Leu Leu Gln Ser Thr Arg Gln Gln Leu Leu Gly Trp Ile Asp Ile 
                85                  90                  95      


Pro Pro Gln Glu Trp Glu Arg Val Tyr Ser Leu Phe Pro Val Ser Leu 
            100                 105                 110         


Trp Lys Asn Phe Ala Thr Ile Ser Arg Asp Leu Asp Ser Leu Leu Gly 
        115                 120                 125             


Asp Ile Arg Ser His Ala Val Ile Val Asp Lys Ser Val Glu Met Ala 
    130                 135                 140                 


Ala Leu His Ala Phe Glu Ser Leu Leu Ala Leu Pro Tyr Ala Ser Pro 
145                 150                 155                 160 


Asn Lys Lys Ala Cys Gln Asp Phe Leu Lys Arg Arg Phe Leu Leu Pro 
                165                 170                 175     


Arg Ala Val Lys Leu Gly Met Asp Arg Val Lys Glu Glu Val Arg Ser 
            180                 185                 190         


Lys Gln Leu Lys Ser Leu Tyr Leu Leu Asp Asn Gly Arg His Glu Leu 
        195                 200                 205             


Val Ser Glu Ile Phe Phe Pro Cys Val Ala Ala Trp Cys Leu Pro Glu 
    210                 215                 220                 


Ile Ile Pro Leu Gly Trp Met Lys Tyr Leu Gln Val Leu Ile Lys Arg 
225                 230                 235                 240 


Gly His Pro Phe Gly Tyr Phe Gly Ala Asp Val Ser Arg Tyr Pro Pro 
                245                 250                 255     


Ala Ile Ala Thr Met Ser Thr Cys Val Ser Thr Leu Phe Asp Leu Ser 
            260                 265                 270         


Leu Val Thr Ser Ala Gln Ala Met His Phe Leu Glu Ile Cys Leu Glu 
        275                 280                 285             


Asn Val Asn Asp Gln Asn Gln Leu Leu Thr Tyr Leu Asp Val Glu Arg 
    290                 295                 300                 


Pro Arg Val Asp Pro Val Val Ile Ala Asn Val Val Tyr Leu Ala Tyr 
305                 310                 315                 320 


Ala Leu Ser Met Glu Asp His Pro Val Val Arg His Asn Glu Asn Leu 
                325                 330                 335     


Ile Gln Arg Tyr Leu Leu Ser Gly Gly Phe Val Tyr Gly Thr Arg Tyr 
            340                 345                 350         


Tyr Leu Ser Gln Glu Asp Phe Leu Phe Met Tyr Gly Arg Val Leu Ala 
        355                 360                 365             


Thr Phe Gly Glu Lys Arg Glu Ile Pro Asn Phe Asp Leu Val Tyr Gln 
    370                 375                 380                 


Ala Met Glu Ala Ala Leu Val Asn Arg Ile Gly Asn Glu Thr Glu Ser 
385                 390                 395                 400 


Lys Pro Leu Asp Val Ala Lys Arg Ile Leu Leu Ser Arg Gly Phe Gly 
                405                 410                 415     


Ile Arg Asn Thr Ile Asp Val Asp Leu Leu Leu Lys Met Gln Asn Glu 
            420                 425                 430         


Asp Gly Ser Trp Pro Leu Gln Val Leu Ser Asn Leu Pro Ser Ala Lys 
        435                 440                 445             


Gly Gly Val Phe Asn Ser Val Val Asp Leu Ser Phe Ala Val Arg Ala 
    450                 455                 460                 


Leu Gln Ser Gln Asp 
465                 


<210>  22
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SmHAD1 mutant of QW motif_E. coli optimized

<400>  22
atgatcatta tcagcttcgc gtgcctgctg aagtttggtt gcggtgacaa cggtccgcgt       60

ggcgatctgc tgcgtcgtgc gctgcagcac agcagcttcc tggcgtatag ctgcggcgag      120

ctggaccgta ccgcggcgat tagcaccatc agccgtaagt ttaaactgac cgacccggcg      180

ctggttgata gcatgctgct ggaagcggcg agcagctgcg aggtggacaa agaactgctg      240

agcctgctgc agagcacccg tcagcaactg ctgggttgga ttgatatccc gccgcaagag      300

tgggaacgtg tgtacagcct gttcccggtt agcctgtgga agaactttgc gaccattagc      360

cgtgacctgg atagcctgct gggcgacatt cgtagccacg cggtgatcgt tgataaaagc      420

gttgagatgg cggcgctgca cgcgttcgaa agcctgctgg cgctgccgta tgcgagcccg      480

aacaagaaag cgtgccagga cttcctgaag cgtcgttttc tgctgccgcg tgcggtgaag      540

ctgggtatgg atcgtgtgaa agaggaagtt cgtagcaagc aactgaaaag cctgtacctg      600

ctggacaacg gccgtcacga gctggttagc gaaattttct ttccgtgcgt tgcggcgtgg      660

tgcctgccgg agattatccc gctgggttgg atgaagtatc tgcaggttct gattaaacgt      720

ggccacccgt tcggttactt tggtgcggat gtgagccgtt atccgccgga catcgatacc      780

atgagcacct gcgtgagcac cctgttcgat ctgagcctgg ttaccagcgc gcaagcgatg      840

cactttctgg agatctgcct ggaaaacgtt aacgaccaga accaactgct gacctacctg      900

gacgtggaac gtccgcgtgt tgatccggtg gttattgcga acgtggttta cctggcgtat      960

gcgctgagca tggaggatca cccggtggtt cgtcacaacg aaaacctgat ccagcgttac     1020

ctgctgagcg gtggcttcgt ttatggcacc cgttactatc tgagccaaga ggacttcctg     1080

tttatgtacg gtcgtgtgct ggcgaccttc ggcgagaaac gtgaaatccc gaactttgat     1140

ctggtgtatc aggcgatgga agcggcgctg gttaaccgta ttggtaacga gaccgaaagc     1200

aagccgctgg acgttgcgaa acgtatcctg ctgagccgtg gttttggcat tcgtaacacc     1260

atcgacgtgg atctgctgct gaagatgcag aacgcggcgg gcagctggcc gctgcaagtg     1320

ctgagcaacc tgccgagcgc gaaaggtggc gttttcaaca gcgtggttga cctgagcttt     1380

gcggtgcgtg cgctgcagag ccaagattaa                                      1410


<210>  23
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SmHAD1 mutant of QW motif

<400>  23

Met Ile Ile Ile Ser Phe Ala Cys Leu Leu Lys Phe Gly Cys Gly Asp 
1               5                   10                  15      


Asn Gly Pro Arg Gly Asp Leu Leu Arg Arg Ala Leu Gln His Ser Ser 
            20                  25                  30          


Phe Leu Ala Tyr Ser Cys Gly Glu Leu Asp Arg Thr Ala Ala Ile Ser 
        35                  40                  45              


Thr Ile Ser Arg Lys Phe Lys Leu Thr Asp Pro Ala Leu Val Asp Ser 
    50                  55                  60                  


Met Leu Leu Glu Ala Ala Ser Ser Cys Glu Val Asp Lys Glu Leu Leu 
65                  70                  75                  80  


Ser Leu Leu Gln Ser Thr Arg Gln Gln Leu Leu Gly Trp Ile Asp Ile 
                85                  90                  95      


Pro Pro Gln Glu Trp Glu Arg Val Tyr Ser Leu Phe Pro Val Ser Leu 
            100                 105                 110         


Trp Lys Asn Phe Ala Thr Ile Ser Arg Asp Leu Asp Ser Leu Leu Gly 
        115                 120                 125             


Asp Ile Arg Ser His Ala Val Ile Val Asp Lys Ser Val Glu Met Ala 
    130                 135                 140                 


Ala Leu His Ala Phe Glu Ser Leu Leu Ala Leu Pro Tyr Ala Ser Pro 
145                 150                 155                 160 


Asn Lys Lys Ala Cys Gln Asp Phe Leu Lys Arg Arg Phe Leu Leu Pro 
                165                 170                 175     


Arg Ala Val Lys Leu Gly Met Asp Arg Val Lys Glu Glu Val Arg Ser 
            180                 185                 190         


Lys Gln Leu Lys Ser Leu Tyr Leu Leu Asp Asn Gly Arg His Glu Leu 
        195                 200                 205             


Val Ser Glu Ile Phe Phe Pro Cys Val Ala Ala Trp Cys Leu Pro Glu 
    210                 215                 220                 


Ile Ile Pro Leu Gly Trp Met Lys Tyr Leu Gln Val Leu Ile Lys Arg 
225                 230                 235                 240 


Gly His Pro Phe Gly Tyr Phe Gly Ala Asp Val Ser Arg Tyr Pro Pro 
                245                 250                 255     


Asp Ile Asp Thr Met Ser Thr Cys Val Ser Thr Leu Phe Asp Leu Ser 
            260                 265                 270         


Leu Val Thr Ser Ala Gln Ala Met His Phe Leu Glu Ile Cys Leu Glu 
        275                 280                 285             


Asn Val Asn Asp Gln Asn Gln Leu Leu Thr Tyr Leu Asp Val Glu Arg 
    290                 295                 300                 


Pro Arg Val Asp Pro Val Val Ile Ala Asn Val Val Tyr Leu Ala Tyr 
305                 310                 315                 320 


Ala Leu Ser Met Glu Asp His Pro Val Val Arg His Asn Glu Asn Leu 
                325                 330                 335     


Ile Gln Arg Tyr Leu Leu Ser Gly Gly Phe Val Tyr Gly Thr Arg Tyr 
            340                 345                 350         


Tyr Leu Ser Gln Glu Asp Phe Leu Phe Met Tyr Gly Arg Val Leu Ala 
        355                 360                 365             


Thr Phe Gly Glu Lys Arg Glu Ile Pro Asn Phe Asp Leu Val Tyr Gln 
    370                 375                 380                 


Ala Met Glu Ala Ala Leu Val Asn Arg Ile Gly Asn Glu Thr Glu Ser 
385                 390                 395                 400 


Lys Pro Leu Asp Val Ala Lys Arg Ile Leu Leu Ser Arg Gly Phe Gly 
                405                 410                 415     


Ile Arg Asn Thr Ile Asp Val Asp Leu Leu Leu Lys Met Gln Asn Ala 
            420                 425                 430         


Ala Gly Ser Trp Pro Leu Gln Val Leu Ser Asn Leu Pro Ser Ala Lys 
        435                 440                 445             


Gly Gly Val Phe Asn Ser Val Val Asp Leu Ser Phe Ala Val Arg Ala 
    450                 455                 460                 


Leu Gln Ser Gln Asp 
465                 


<210>  24
<211>  1410
<212>  DNA
<213>  Selaginella moellendorffii


<220>
<221>  misc_feature
<223>  SmHAD2_wt_nucleic acid sequence

<400>  24
atgataatca ttagttttgc ttgcttgctt aagttcggat gtggagacag tggcccccgg       60

ggagatctcc tccgcagggc tctccagcac tcctccttct tggcctattc ttgcggggag      120

ctcgatcgcg ctgccgcaat ctcgacaatc tcgcgcaaat tcaagctcaa ggagccagct      180

ctcctggatt ccatgctgct cgaggccgct tccagctgcg aggtggacga ggagctactg      240

tcactgctcc agtcaacgag gcagcagctc ctgggatgga ttgatattcc tccacaagag      300

tgggagcgag tttacaacct cttcccgtgg tcgctctgga agaacttcgc tacaatctcc      360

cgcgatctag attccctcct tggagatatc aggttccatg ctgtgattgt cgataaaagc      420

gtggagatgg ccgcgctaca tgccttcgag agcttgctcg ctctcccgta tgcctcgccc      480

aacaagaaag cttgccagga cttcttgaag cgtcggttcc tgctgcctcg agctgtgaag      540

ctggggatgg atcgagtcaa ggaggaggtg agatccaagc agctcaaatc actctacctg      600

cttgacaacg gccggcagga gctcgtctcc gagatcttct ttccctgcgt ggcggcctgg      660

tgccttcctg agatcattcc tctcggctgg atggaatctc tccaggtact gatcgagcgc      720

ggccatccct tcggttactt cggtgccgac gtctcgcgct atccgccgga catcgacacc      780

atgtcgactt gtgtctccac actttttgat cttagcctcg tcacctccgc gcaagctatg      840

cactttctgg agatttgtct cgagaacgtc aacgatcaaa accagcttct cacgtacctg      900

gacttggagc ggcctcgagt ggatccggtc gtcatagcca acgttgtcta tttcgcctat      960

gcgctctcca tggaagatca cccggttgtc cgccacaacg agaatctgat ccagagatat     1020

ctgttaagcg gcggattcgt atacgggact cgctattacc tcagccagga ggacttcttg     1080

ttcatgtatg gccgggtcct cgcgacgttt ggagagaaga gggagattcc caactttgat     1140

ctcgtgtatc aagcgatgga ggcggctctc gtcaaccgga tcgggaacga gaccgagtcg     1200

aagccactgg acgttgccaa aaggattctg ctcagcaggt actttggaat ccggaacacg     1260

atagatgtgg acttgctcct caagatgcag aacgaggatg gttcctggcc cttgcaagtg     1320

ctcagcaatc ttccatctgc taaaggtggt gtcttcaatt cggtggtgga cttgagcttt     1380

gcggtgagag cactgcaaag tcaagattga                                      1410


<210>  25
<211>  1410
<212>  DNA
<213>  Selaginella moellendorffii


<220>
<221>  misc_feature
<223>  SmHAD2_E. coli optimized

<400>  25
atgatcatta tcagcttcgc gtgcctgctg aaatttggtt gcggtgatag cggtccgcgt       60

ggcgatctgc tgcgtcgtgc gctgcagcac agcagcttcc tggcgtatag ctgcggcgag      120

ctggaccgtg cggcggcgat tagcaccatc agccgtaagt ttaaactgaa ggaaccggcg      180

ctgctggaca gcatgctgct ggaggcggcg agcagctgcg aagttgatga ggaactgctg      240

agcctgctgc agagcacccg tcagcaactg ctgggttgga ttgatatccc gccgcaagag      300

tgggaacgtg tgtataacct gttcccgtgg agcctgtgga aaaactttgc gaccattagc      360

cgtgacctgg atagcctgct gggcgacatt cgtttccacg cggtgatcgt tgataagagc      420

gttgagatgg cggcgctgca cgcgtttgaa agcctgctgg cgctgccgta cgcgagcccg      480

aacaagaaag cgtgccaaga cttcctgaag cgtcgttttc tgctgccgcg tgcggtgaaa      540

ctgggtatgg atcgtgtgaa ggaagaggtg cgcagcaaac agctgaagag cctgtatctg      600

ctggacaacg gccgtcaaga gctggttagc gaaattttct ttccgtgcgt tgcggcgtgg      660

tgcctgccgg agattatccc gctgggttgg atggagagcc tgcaggttct gattgaacgt      720

ggccacccgt tcggttactt tggtgcggat gtgagccgtt atccgccgga catcgatacc      780

atgagcacct gcgtgagcac cctgttcgat ctgagcctgg ttaccagcgc gcaagcgatg      840

cactttctgg agatctgcct ggaaaacgtt aacgaccaga accaactgct gacctacctg      900

gacctggaac gtccgcgtgt ggatccggtg gttattgcga acgtggttta cttcgcgtat      960

gcgctgagca tggaggatca cccggtggtt cgtcacaacg aaaacctgat ccagcgttac     1020

ctgctgagcg gtggctttgt ttatggcacc cgttactatc tgagccaaga ggacttcctg     1080

tttatgtacg gtcgtgtgct ggcgaccttc ggcgagaaac gtgaaatccc gaactttgat     1140

ctggtgtatc aggcgatgga agcggcgctg gttaaccgta ttggcaacga gaccgaaagc     1200

aaaccgctgg acgttgcgaa gcgtatcctg ctgagccgtt acttcggtat tcgtaacacc     1260

atcgacgtgg atctgctgct gaaaatgcag aacgaggatg gcagctggcc gctgcaagtg     1320

ctgagcaacc tgccgagcgc gaagggtggc gttttcaaca gcgtggttga cctgagcttt     1380

gcggtgcgtg cgctgcagag ccaagattaa                                      1410


<210>  26
<211>  469
<212>  PRT
<213>  Selaginella moellendorffii


<220>
<221>  MISC_FEATURE
<223>  SmHAD2_amino acid sequence

<400>  26

Met Ile Ile Ile Ser Phe Ala Cys Leu Leu Lys Phe Gly Cys Gly Asp 
1               5                   10                  15      


Ser Gly Pro Arg Gly Asp Leu Leu Arg Arg Ala Leu Gln His Ser Ser 
            20                  25                  30          


Phe Leu Ala Tyr Ser Cys Gly Glu Leu Asp Arg Ala Ala Ala Ile Ser 
        35                  40                  45              


Thr Ile Ser Arg Lys Phe Lys Leu Lys Glu Pro Ala Leu Leu Asp Ser 
    50                  55                  60                  


Met Leu Leu Glu Ala Ala Ser Ser Cys Glu Val Asp Glu Glu Leu Leu 
65                  70                  75                  80  


Ser Leu Leu Gln Ser Thr Arg Gln Gln Leu Leu Gly Trp Ile Asp Ile 
                85                  90                  95      


Pro Pro Gln Glu Trp Glu Arg Val Tyr Asn Leu Phe Pro Trp Ser Leu 
            100                 105                 110         


Trp Lys Asn Phe Ala Thr Ile Ser Arg Asp Leu Asp Ser Leu Leu Gly 
        115                 120                 125             


Asp Ile Arg Phe His Ala Val Ile Val Asp Lys Ser Val Glu Met Ala 
    130                 135                 140                 


Ala Leu His Ala Phe Glu Ser Leu Leu Ala Leu Pro Tyr Ala Ser Pro 
145                 150                 155                 160 


Asn Lys Lys Ala Cys Gln Asp Phe Leu Lys Arg Arg Phe Leu Leu Pro 
                165                 170                 175     


Arg Ala Val Lys Leu Gly Met Asp Arg Val Lys Glu Glu Val Arg Ser 
            180                 185                 190         


Lys Gln Leu Lys Ser Leu Tyr Leu Leu Asp Asn Gly Arg Gln Glu Leu 
        195                 200                 205             


Val Ser Glu Ile Phe Phe Pro Cys Val Ala Ala Trp Cys Leu Pro Glu 
    210                 215                 220                 


Ile Ile Pro Leu Gly Trp Met Glu Ser Leu Gln Val Leu Ile Glu Arg 
225                 230                 235                 240 


Gly His Pro Phe Gly Tyr Phe Gly Ala Asp Val Ser Arg Tyr Pro Pro 
                245                 250                 255     


Asp Ile Asp Thr Met Ser Thr Cys Val Ser Thr Leu Phe Asp Leu Ser 
            260                 265                 270         


Leu Val Thr Ser Ala Gln Ala Met His Phe Leu Glu Ile Cys Leu Glu 
        275                 280                 285             


Asn Val Asn Asp Gln Asn Gln Leu Leu Thr Tyr Leu Asp Leu Glu Arg 
    290                 295                 300                 


Pro Arg Val Asp Pro Val Val Ile Ala Asn Val Val Tyr Phe Ala Tyr 
305                 310                 315                 320 


Ala Leu Ser Met Glu Asp His Pro Val Val Arg His Asn Glu Asn Leu 
                325                 330                 335     


Ile Gln Arg Tyr Leu Leu Ser Gly Gly Phe Val Tyr Gly Thr Arg Tyr 
            340                 345                 350         


Tyr Leu Ser Gln Glu Asp Phe Leu Phe Met Tyr Gly Arg Val Leu Ala 
        355                 360                 365             


Thr Phe Gly Glu Lys Arg Glu Ile Pro Asn Phe Asp Leu Val Tyr Gln 
    370                 375                 380                 


Ala Met Glu Ala Ala Leu Val Asn Arg Ile Gly Asn Glu Thr Glu Ser 
385                 390                 395                 400 


Lys Pro Leu Asp Val Ala Lys Arg Ile Leu Leu Ser Arg Tyr Phe Gly 
                405                 410                 415     


Ile Arg Asn Thr Ile Asp Val Asp Leu Leu Leu Lys Met Gln Asn Glu 
            420                 425                 430         


Asp Gly Ser Trp Pro Leu Gln Val Leu Ser Asn Leu Pro Ser Ala Lys 
        435                 440                 445             


Gly Gly Val Phe Asn Ser Val Val Asp Leu Ser Phe Ala Val Arg Ala 
    450                 455                 460                 


Leu Gln Ser Gln Asp 
465                 


<210>  27
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SmHAD2 mutant of class II motif_E. coli optimized

<400>  27
atgatcatta tcagcttcgc gtgcctgctg aaatttggtt gcggtgatag cggtccgcgt       60

ggcgatctgc tgcgtcgtgc gctgcagcac agcagcttcc tggcgtatag ctgcggcgag      120

ctggaccgtg cggcggcgat tagcaccatc agccgtaagt ttaaactgaa ggaaccggcg      180

ctgctggaca gcatgctgct ggaggcggcg agcagctgcg aagttgatga ggaactgctg      240

agcctgctgc agagcacccg tcagcaactg ctgggttgga ttgatatccc gccgcaagag      300

tgggaacgtg tgtataacct gttcccgtgg agcctgtgga aaaactttgc gaccattagc      360

cgtgacctgg atagcctgct gggcgacatt cgtttccacg cggtgatcgt tgataagagc      420

gttgagatgg cggcgctgca cgcgtttgaa agcctgctgg cgctgccgta cgcgagcccg      480

aacaagaaag cgtgccaaga cttcctgaag cgtcgttttc tgctgccgcg tgcggtgaaa      540

ctgggtatgg atcgtgtgaa ggaagaggtg cgcagcaaac agctgaagag cctgtatctg      600

ctggacaacg gccgtcaaga gctggttagc gaaattttct ttccgtgcgt tgcggcgtgg      660

tgcctgccgg agattatccc gctgggttgg atggagagcc tgcaggttct gattgaacgt      720

ggccacccgt tcggttactt tggtgcggat gtgagccgtt atccgccggc gatcgcgacc      780

atgagcacct gcgtgagcac cctgttcgat ctgagcctgg ttaccagcgc gcaagcgatg      840

cactttctgg agatctgcct ggaaaacgtt aacgaccaga accaactgct gacctacctg      900

gacctggaac gtccgcgtgt ggatccggtg gttattgcga acgtggttta cttcgcgtat      960

gcgctgagca tggaggatca cccggtggtt cgtcacaacg aaaacctgat ccagcgttac     1020

ctgctgagcg gtggctttgt ttatggcacc cgttactatc tgagccaaga ggacttcctg     1080

tttatgtacg gtcgtgtgct ggcgaccttc ggcgagaaac gtgaaatccc gaactttgat     1140

ctggtgtatc aggcgatgga agcggcgctg gttaaccgta ttggcaacga gaccgaaagc     1200

aaaccgctgg acgttgcgaa gcgtatcctg ctgagccgtt acttcggtat tcgtaacacc     1260

atcgacgtgg atctgctgct gaaaatgcag aacgaggatg gcagctggcc gctgcaagtg     1320

ctgagcaacc tgccgagcgc gaagggtggc gttttcaaca gcgtggttga cctgagcttt     1380

gcggtgcgtg cgctgcagag ccaagattaa                                      1410


<210>  28
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SmHAD2 mutant of class II motif

<400>  28

Met Ile Ile Ile Ser Phe Ala Cys Leu Leu Lys Phe Gly Cys Gly Asp 
1               5                   10                  15      


Ser Gly Pro Arg Gly Asp Leu Leu Arg Arg Ala Leu Gln His Ser Ser 
            20                  25                  30          


Phe Leu Ala Tyr Ser Cys Gly Glu Leu Asp Arg Ala Ala Ala Ile Ser 
        35                  40                  45              


Thr Ile Ser Arg Lys Phe Lys Leu Lys Glu Pro Ala Leu Leu Asp Ser 
    50                  55                  60                  


Met Leu Leu Glu Ala Ala Ser Ser Cys Glu Val Asp Glu Glu Leu Leu 
65                  70                  75                  80  


Ser Leu Leu Gln Ser Thr Arg Gln Gln Leu Leu Gly Trp Ile Asp Ile 
                85                  90                  95      


Pro Pro Gln Glu Trp Glu Arg Val Tyr Asn Leu Phe Pro Trp Ser Leu 
            100                 105                 110         


Trp Lys Asn Phe Ala Thr Ile Ser Arg Asp Leu Asp Ser Leu Leu Gly 
        115                 120                 125             


Asp Ile Arg Phe His Ala Val Ile Val Asp Lys Ser Val Glu Met Ala 
    130                 135                 140                 


Ala Leu His Ala Phe Glu Ser Leu Leu Ala Leu Pro Tyr Ala Ser Pro 
145                 150                 155                 160 


Asn Lys Lys Ala Cys Gln Asp Phe Leu Lys Arg Arg Phe Leu Leu Pro 
                165                 170                 175     


Arg Ala Val Lys Leu Gly Met Asp Arg Val Lys Glu Glu Val Arg Ser 
            180                 185                 190         


Lys Gln Leu Lys Ser Leu Tyr Leu Leu Asp Asn Gly Arg Gln Glu Leu 
        195                 200                 205             


Val Ser Glu Ile Phe Phe Pro Cys Val Ala Ala Trp Cys Leu Pro Glu 
    210                 215                 220                 


Ile Ile Pro Leu Gly Trp Met Glu Ser Leu Gln Val Leu Ile Glu Arg 
225                 230                 235                 240 


Gly His Pro Phe Gly Tyr Phe Gly Ala Asp Val Ser Arg Tyr Pro Pro 
                245                 250                 255     


Ala Ile Ala Thr Met Ser Thr Cys Val Ser Thr Leu Phe Asp Leu Ser 
            260                 265                 270         


Leu Val Thr Ser Ala Gln Ala Met His Phe Leu Glu Ile Cys Leu Glu 
        275                 280                 285             


Asn Val Asn Asp Gln Asn Gln Leu Leu Thr Tyr Leu Asp Leu Glu Arg 
    290                 295                 300                 


Pro Arg Val Asp Pro Val Val Ile Ala Asn Val Val Tyr Phe Ala Tyr 
305                 310                 315                 320 


Ala Leu Ser Met Glu Asp His Pro Val Val Arg His Asn Glu Asn Leu 
                325                 330                 335     


Ile Gln Arg Tyr Leu Leu Ser Gly Gly Phe Val Tyr Gly Thr Arg Tyr 
            340                 345                 350         


Tyr Leu Ser Gln Glu Asp Phe Leu Phe Met Tyr Gly Arg Val Leu Ala 
        355                 360                 365             


Thr Phe Gly Glu Lys Arg Glu Ile Pro Asn Phe Asp Leu Val Tyr Gln 
    370                 375                 380                 


Ala Met Glu Ala Ala Leu Val Asn Arg Ile Gly Asn Glu Thr Glu Ser 
385                 390                 395                 400 


Lys Pro Leu Asp Val Ala Lys Arg Ile Leu Leu Ser Arg Tyr Phe Gly 
                405                 410                 415     


Ile Arg Asn Thr Ile Asp Val Asp Leu Leu Leu Lys Met Gln Asn Glu 
            420                 425                 430         


Asp Gly Ser Trp Pro Leu Gln Val Leu Ser Asn Leu Pro Ser Ala Lys 
        435                 440                 445             


Gly Gly Val Phe Asn Ser Val Val Asp Leu Ser Phe Ala Val Arg Ala 
    450                 455                 460                 


Leu Gln Ser Gln Asp 
465                 


<210>  29
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SmHAD2 mutant of QW motif_E. coli optimized

<400>  29
atgatcatta tcagcttcgc gtgcctgctg aaatttggtt gcggtgatag cggtccgcgt       60

ggcgatctgc tgcgtcgtgc gctgcagcac agcagcttcc tggcgtatag ctgcggcgag      120

ctggaccgtg cggcggcgat tagcaccatc agccgtaagt ttaaactgaa ggaaccggcg      180

ctgctggaca gcatgctgct ggaggcggcg agcagctgcg aagttgatga ggaactgctg      240

agcctgctgc agagcacccg tcagcaactg ctgggttgga ttgatatccc gccgcaagag      300

tgggaacgtg tgtataacct gttcccgtgg agcctgtgga aaaactttgc gaccattagc      360

cgtgacctgg atagcctgct gggcgacatt cgtttccacg cggtgatcgt tgataagagc      420

gttgagatgg cggcgctgca cgcgtttgaa agcctgctgg cgctgccgta cgcgagcccg      480

aacaagaaag cgtgccaaga cttcctgaag cgtcgttttc tgctgccgcg tgcggtgaaa      540

ctgggtatgg atcgtgtgaa ggaagaggtg cgcagcaaac agctgaagag cctgtatctg      600

ctggacaacg gccgtcaaga gctggttagc gaaattttct ttccgtgcgt tgcggcgtgg      660

tgcctgccgg agattatccc gctgggttgg atggagagcc tgcaggttct gattgaacgt      720

ggccacccgt tcggttactt tggtgcggat gtgagccgtt atccgccgga catcgatacc      780

atgagcacct gcgtgagcac cctgttcgat ctgagcctgg ttaccagcgc gcaagcgatg      840

cactttctgg agatctgcct ggaaaacgtt aacgaccaga accaactgct gacctacctg      900

gacctggaac gtccgcgtgt ggatccggtg gttattgcga acgtggttta cttcgcgtat      960

gcgctgagca tggaggatca cccggtggtt cgtcacaacg aaaacctgat ccagcgttac     1020

ctgctgagcg gtggctttgt ttatggcacc cgttactatc tgagccaaga ggacttcctg     1080

tttatgtacg gtcgtgtgct ggcgaccttc ggcgagaaac gtgaaatccc gaactttgat     1140

ctggtgtatc aggcgatgga agcggcgctg gttaaccgta ttggcaacga gaccgaaagc     1200

aaaccgctgg acgttgcgaa gcgtatcctg ctgagccgtt acttcggtat tcgtaacacc     1260

atcgacgtgg atctgctgct gaaaatgcag aacgcggcgg gcagctggcc gctgcaagtg     1320

ctgagcaacc tgccgagcgc gaagggtggc gttttcaaca gcgtggttga cctgagcttt     1380

gcggtgcgtg cgctgcagag ccaagattaa                                      1410


<210>  30
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SmHAD2 mutant of QW motif

<400>  30

Met Ile Ile Ile Ser Phe Ala Cys Leu Leu Lys Phe Gly Cys Gly Asp 
1               5                   10                  15      


Ser Gly Pro Arg Gly Asp Leu Leu Arg Arg Ala Leu Gln His Ser Ser 
            20                  25                  30          


Phe Leu Ala Tyr Ser Cys Gly Glu Leu Asp Arg Ala Ala Ala Ile Ser 
        35                  40                  45              


Thr Ile Ser Arg Lys Phe Lys Leu Lys Glu Pro Ala Leu Leu Asp Ser 
    50                  55                  60                  


Met Leu Leu Glu Ala Ala Ser Ser Cys Glu Val Asp Glu Glu Leu Leu 
65                  70                  75                  80  


Ser Leu Leu Gln Ser Thr Arg Gln Gln Leu Leu Gly Trp Ile Asp Ile 
                85                  90                  95      


Pro Pro Gln Glu Trp Glu Arg Val Tyr Asn Leu Phe Pro Trp Ser Leu 
            100                 105                 110         


Trp Lys Asn Phe Ala Thr Ile Ser Arg Asp Leu Asp Ser Leu Leu Gly 
        115                 120                 125             


Asp Ile Arg Phe His Ala Val Ile Val Asp Lys Ser Val Glu Met Ala 
    130                 135                 140                 


Ala Leu His Ala Phe Glu Ser Leu Leu Ala Leu Pro Tyr Ala Ser Pro 
145                 150                 155                 160 


Asn Lys Lys Ala Cys Gln Asp Phe Leu Lys Arg Arg Phe Leu Leu Pro 
                165                 170                 175     


Arg Ala Val Lys Leu Gly Met Asp Arg Val Lys Glu Glu Val Arg Ser 
            180                 185                 190         


Lys Gln Leu Lys Ser Leu Tyr Leu Leu Asp Asn Gly Arg Gln Glu Leu 
        195                 200                 205             


Val Ser Glu Ile Phe Phe Pro Cys Val Ala Ala Trp Cys Leu Pro Glu 
    210                 215                 220                 


Ile Ile Pro Leu Gly Trp Met Glu Ser Leu Gln Val Leu Ile Glu Arg 
225                 230                 235                 240 


Gly His Pro Phe Gly Tyr Phe Gly Ala Asp Val Ser Arg Tyr Pro Pro 
                245                 250                 255     


Asp Ile Asp Thr Met Ser Thr Cys Val Ser Thr Leu Phe Asp Leu Ser 
            260                 265                 270         


Leu Val Thr Ser Ala Gln Ala Met His Phe Leu Glu Ile Cys Leu Glu 
        275                 280                 285             


Asn Val Asn Asp Gln Asn Gln Leu Leu Thr Tyr Leu Asp Leu Glu Arg 
    290                 295                 300                 


Pro Arg Val Asp Pro Val Val Ile Ala Asn Val Val Tyr Phe Ala Tyr 
305                 310                 315                 320 


Ala Leu Ser Met Glu Asp His Pro Val Val Arg His Asn Glu Asn Leu 
                325                 330                 335     


Ile Gln Arg Tyr Leu Leu Ser Gly Gly Phe Val Tyr Gly Thr Arg Tyr 
            340                 345                 350         


Tyr Leu Ser Gln Glu Asp Phe Leu Phe Met Tyr Gly Arg Val Leu Ala 
        355                 360                 365             


Thr Phe Gly Glu Lys Arg Glu Ile Pro Asn Phe Asp Leu Val Tyr Gln 
    370                 375                 380                 


Ala Met Glu Ala Ala Leu Val Asn Arg Ile Gly Asn Glu Thr Glu Ser 
385                 390                 395                 400 


Lys Pro Leu Asp Val Ala Lys Arg Ile Leu Leu Ser Arg Tyr Phe Gly 
                405                 410                 415     


Ile Arg Asn Thr Ile Asp Val Asp Leu Leu Leu Lys Met Gln Asn Ala 
            420                 425                 430         


Ala Gly Ser Trp Pro Leu Gln Val Leu Ser Asn Leu Pro Ser Ala Lys 
        435                 440                 445             


Gly Gly Val Phe Asn Ser Val Val Asp Leu Ser Phe Ala Val Arg Ala 
    450                 455                 460                 


Leu Gln Ser Gln Asp 
465                 


<210>  31
<211>  1602
<212>  DNA
<213>  Gelatoporia subvermispora


<220>
<221>  misc_feature
<223>  EMD37666.1_E. coli optimized

<400>  31
atgtctgcgg cggctcaata cacgactttg attctggatc tgggtgatgt tctgttcact       60

tggtccccga aaaccaagac cagcatccct ccgcgtaccc tgaaagaaat cctgaatagc      120

gctacctggt atgagtacga gcgtggtcgc atttcccaag acgagtgtta cgaacgtgtg      180

ggcaccgagt tcggcattgc gccgagcgag attgacaacg cgttcaaaca agcgcgcgat      240

tcgatggaaa gcaatgatga actgatcgca ctggtccgtg agctgaaaac gcagctggac      300

ggtgagctgc tggttttcgc actgtccaat attagcctgc cggattacga atacgtcttg      360

accaaaccgg cggactggag catctttgac aaagtgttcc ctagcgcctt ggtgggcgag      420

cgtaagccgc atctgggcgt ttataaacac gttattgcgg aaacgggcat tgatccgcgc      480

acgacggttt tcgtggacga caagattgac aatgtgttaa gcgcacgcag cgtcggtatg      540

catggtatcg tgtttgagaa acaagaagat gtcatgcgtg cactgcgtaa catctttggt      600

gatccggtcc gtcgtggtcg tgagtatctg cgtagaaacg caatgcgtct ggagtccgtg      660

accgaccacg gcgtggcgtt tggtgagaac tttacccagt tgctgattct ggaattgacg      720

aacgacccga gcctggtcac cctgcctgat cgtccgcgta cctggaactt ttttcgcggc      780

aatggtggcc gcccgagcaa gccgctgttc agcgaagcgt tcccggatga tctggatacc      840

acgagcctgg cgctgaccgt gctgcagcgc gacccgggtg ttatcagcag cgttatggac      900

gaaatgctga attaccgtga cccggacggt atcatgcaga cttatttcga tgacggtcgc      960

caacgcttgg acccatttgt gaacgtcaat gttctgacct ttttctatac gaacggccgt     1020

ggtcacgaac tggaccagtg tctgacgtgg gtgcgtgaag tcctcttgta tcgtgcgtac     1080

cttggtggct cacgctacta cccatcggcg gattgcttcc tgtacttcat ctctcgtctg     1140

tttgcgtgta ccaatgaccc ggtgctgcac catcagctga agccactgtt tgttgagcgt     1200

gtccaagagc aaattggtgt cgagggtgat gcactggaac tggcttttcg tctgctggtc     1260

tgcgccagcc tggatgtcca gaatgccatc gacatgcgcc gtctgctgga aatgcagtgc     1320

gaagatggcg gttgggaggg tggtaacctc taccgcttcg gcaccacggg cctgaaagtt     1380

accaaccgcg gtctgacgac cgcagccgcc gttcaagcga tcgaagcgag ccaacgccgt     1440

ccgccgagcc cgagcccgtc tgtagagagc acgaaaagcc cgattacccc ggtgaccccg     1500

atgctggaag ttccaagcct gggcttatct atcagccgtc cgtccagccc gctgctgggt     1560

tatttccgtt tgccgtggaa gaaaagcgca gaagtgcact aa                        1602


<210>  32
<211>  533
<212>  PRT
<213>  Gelatoporia subvermispora


<220>
<221>  MISC_FEATURE
<223>  EMD37666.1_amino acid sequence

<400>  32

Met Ser Ala Ala Ala Gln Tyr Thr Thr Leu Ile Leu Asp Leu Gly Asp 
1               5                   10                  15      


Val Leu Phe Thr Trp Ser Pro Lys Thr Lys Thr Ser Ile Pro Pro Arg 
            20                  25                  30          


Thr Leu Lys Glu Ile Leu Asn Ser Ala Thr Trp Tyr Glu Tyr Glu Arg 
        35                  40                  45              


Gly Arg Ile Ser Gln Asp Glu Cys Tyr Glu Arg Val Gly Thr Glu Phe 
    50                  55                  60                  


Gly Ile Ala Pro Ser Glu Ile Asp Asn Ala Phe Lys Gln Ala Arg Asp 
65                  70                  75                  80  


Ser Met Glu Ser Asn Asp Glu Leu Ile Ala Leu Val Arg Glu Leu Lys 
                85                  90                  95      


Thr Gln Leu Asp Gly Glu Leu Leu Val Phe Ala Leu Ser Asn Ile Ser 
            100                 105                 110         


Leu Pro Asp Tyr Glu Tyr Val Leu Thr Lys Pro Ala Asp Trp Ser Ile 
        115                 120                 125             


Phe Asp Lys Val Phe Pro Ser Ala Leu Val Gly Glu Arg Lys Pro His 
    130                 135                 140                 


Leu Gly Val Tyr Lys His Val Ile Ala Glu Thr Gly Ile Asp Pro Arg 
145                 150                 155                 160 


Thr Thr Val Phe Val Asp Asp Lys Ile Asp Asn Val Leu Ser Ala Arg 
                165                 170                 175     


Ser Val Gly Met His Gly Ile Val Phe Glu Lys Gln Glu Asp Val Met 
            180                 185                 190         


Arg Ala Leu Arg Asn Ile Phe Gly Asp Pro Val Arg Arg Gly Arg Glu 
        195                 200                 205             


Tyr Leu Arg Arg Asn Ala Met Arg Leu Glu Ser Val Thr Asp His Gly 
    210                 215                 220                 


Val Ala Phe Gly Glu Asn Phe Thr Gln Leu Leu Ile Leu Glu Leu Thr 
225                 230                 235                 240 


Asn Asp Pro Ser Leu Val Thr Leu Pro Asp Arg Pro Arg Thr Trp Asn 
                245                 250                 255     


Phe Phe Arg Gly Asn Gly Gly Arg Pro Ser Lys Pro Leu Phe Ser Glu 
            260                 265                 270         


Ala Phe Pro Asp Asp Leu Asp Thr Thr Ser Leu Ala Leu Thr Val Leu 
        275                 280                 285             


Gln Arg Asp Pro Gly Val Ile Ser Ser Val Met Asp Glu Met Leu Asn 
    290                 295                 300                 


Tyr Arg Asp Pro Asp Gly Ile Met Gln Thr Tyr Phe Asp Asp Gly Arg 
305                 310                 315                 320 


Gln Arg Leu Asp Pro Phe Val Asn Val Asn Val Leu Thr Phe Phe Tyr 
                325                 330                 335     


Thr Asn Gly Arg Gly His Glu Leu Asp Gln Cys Leu Thr Trp Val Arg 
            340                 345                 350         


Glu Val Leu Leu Tyr Arg Ala Tyr Leu Gly Gly Ser Arg Tyr Tyr Pro 
        355                 360                 365             


Ser Ala Asp Cys Phe Leu Tyr Phe Ile Ser Arg Leu Phe Ala Cys Thr 
    370                 375                 380                 


Asn Asp Pro Val Leu His His Gln Leu Lys Pro Leu Phe Val Glu Arg 
385                 390                 395                 400 


Val Gln Glu Gln Ile Gly Val Glu Gly Asp Ala Leu Glu Leu Ala Phe 
                405                 410                 415     


Arg Leu Leu Val Cys Ala Ser Leu Asp Val Gln Asn Ala Ile Asp Met 
            420                 425                 430         


Arg Arg Leu Leu Glu Met Gln Cys Glu Asp Gly Gly Trp Glu Gly Gly 
        435                 440                 445             


Asn Leu Tyr Arg Phe Gly Thr Thr Gly Leu Lys Val Thr Asn Arg Gly 
    450                 455                 460                 


Leu Thr Thr Ala Ala Ala Val Gln Ala Ile Glu Ala Ser Gln Arg Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Ser Pro Ser Val Glu Ser Thr Lys Ser Pro Ile Thr 
                485                 490                 495     


Pro Val Thr Pro Met Leu Glu Val Pro Ser Leu Gly Leu Ser Ile Ser 
            500                 505                 510         


Arg Pro Ser Ser Pro Leu Leu Gly Tyr Phe Arg Leu Pro Trp Lys Lys 
        515                 520                 525             


Ser Ala Glu Val His 
    530             


<210>  33
<211>  1602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EMD37666.1_mutant of class II motif_E.coli optimized

<400>  33
atgagcgcgg cggcgcagta caccaccctg atcctggacc tgggtgatgt gctgttcacc       60

tggagcccga agaccaaaac cagcatcccg ccgcgtaccc tgaaggaaat tctgaacagc      120

gcgacctggt acgagtatga acgtggccgt atcagccaag acgagtgcta tgaacgtgtt      180

ggcaccgagt tcggcatcgc gccgagcgaa attgataacg cgtttaagca ggcgcgtgac      240

agcatggaga gcaacgatga actgattgcg ctggtgcgtg agctgaaaac ccaactggac      300

ggtgaactgc tggttttcgc gctgagcaac atcagcctgc cggattacga gtatgtgctg      360

accaagccgg cggactggag cattttcgat aaagtttttc cgagcgcgct ggttggtgaa      420

cgcaagccgc acctgggcgt ttacaaacac gtgatcgcgg aaaccggtat tgacccgcgt      480

accaccgtgt ttgttgacga taagatcgat aacgttctga gcgcgcgtag cgtgggtatg      540

cacggcattg ttttcgagaa acaggaagac gtgatgcgtg cgctgcgtaa catctttggt      600

gatccggttc gtcgtggccg tgagtatctg cgtcgtaacg cgatgcgtct ggaaagcgtt      660

accgaccacg gtgtggcgtt cggcgagaac tttacccaac tgctgattct ggaactgacc      720

aacgatccga gcctggtgac cctgccggat cgtccgcgta cctggaactt ctttcgtggt      780

aacggtggcc gtccgagcaa gccgctgttc agcgaagcgt ttccggcggc gctggcgacc      840

accagcctgg cgctgaccgt tctgcagcgt gacccgggcg ttatcagcag cgtgatggat      900

gagatgctga actaccgtga cccggatggt attatgcaga cctatttcga cgatggccgt      960

caacgtctgg acccgtttgt gaacgttaac gtgctgacct tcttttacac caacggtcgt     1020

ggccacgagc tggatcagtg cctgacctgg gttcgtgaag tgctgctgta ccgtgcgtat     1080

ctgggtggca gccgttacta tccgagcgcg gactgcttcc tgtattttat cagccgtctg     1140

ttcgcgtgca ccaacgatcc ggtgctgcac caccaactga aaccgctgtt tgttgagcgt     1200

gtgcaggaac aaatcggtgt tgagggcgac gcgctggaac tggcgttccg tctgctggtg     1260

tgcgcgagcc tggacgttca gaacgcgatt gatatgcgtc gtctgctgga gatgcaatgc     1320

gaagatggtg gctgggaagg tggcaacctg taccgttttg gcaccaccgg cctgaaggtg     1380

accaaccgtg gtctgaccac cgcggcggcg gttcaggcga ttgaggcgag ccaacgtcgt     1440

ccgccgagcc cgagcccgag cgtggaaagc accaaaagcc cgatcacccc ggtgaccccg     1500

atgctggaag tgccgagcct gggtctgagc attagccgtc cgagcagccc gctgctgggt     1560

tacttccgtc tgccgtggaa gaaaagcgcg gaagtgcact aa                        1602


<210>  34
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMD37666.1_mutant of class II motif

<400>  34

Met Ser Ala Ala Ala Gln Tyr Thr Thr Leu Ile Leu Asp Leu Gly Asp 
1               5                   10                  15      


Val Leu Phe Thr Trp Ser Pro Lys Thr Lys Thr Ser Ile Pro Pro Arg 
            20                  25                  30          


Thr Leu Lys Glu Ile Leu Asn Ser Ala Thr Trp Tyr Glu Tyr Glu Arg 
        35                  40                  45              


Gly Arg Ile Ser Gln Asp Glu Cys Tyr Glu Arg Val Gly Thr Glu Phe 
    50                  55                  60                  


Gly Ile Ala Pro Ser Glu Ile Asp Asn Ala Phe Lys Gln Ala Arg Asp 
65                  70                  75                  80  


Ser Met Glu Ser Asn Asp Glu Leu Ile Ala Leu Val Arg Glu Leu Lys 
                85                  90                  95      


Thr Gln Leu Asp Gly Glu Leu Leu Val Phe Ala Leu Ser Asn Ile Ser 
            100                 105                 110         


Leu Pro Asp Tyr Glu Tyr Val Leu Thr Lys Pro Ala Asp Trp Ser Ile 
        115                 120                 125             


Phe Asp Lys Val Phe Pro Ser Ala Leu Val Gly Glu Arg Lys Pro His 
    130                 135                 140                 


Leu Gly Val Tyr Lys His Val Ile Ala Glu Thr Gly Ile Asp Pro Arg 
145                 150                 155                 160 


Thr Thr Val Phe Val Asp Asp Lys Ile Asp Asn Val Leu Ser Ala Arg 
                165                 170                 175     


Ser Val Gly Met His Gly Ile Val Phe Glu Lys Gln Glu Asp Val Met 
            180                 185                 190         


Arg Ala Leu Arg Asn Ile Phe Gly Asp Pro Val Arg Arg Gly Arg Glu 
        195                 200                 205             


Tyr Leu Arg Arg Asn Ala Met Arg Leu Glu Ser Val Thr Asp His Gly 
    210                 215                 220                 


Val Ala Phe Gly Glu Asn Phe Thr Gln Leu Leu Ile Leu Glu Leu Thr 
225                 230                 235                 240 


Asn Asp Pro Ser Leu Val Thr Leu Pro Asp Arg Pro Arg Thr Trp Asn 
                245                 250                 255     


Phe Phe Arg Gly Asn Gly Gly Arg Pro Ser Lys Pro Leu Phe Ser Glu 
            260                 265                 270         


Ala Phe Pro Ala Ala Leu Ala Thr Thr Ser Leu Ala Leu Thr Val Leu 
        275                 280                 285             


Gln Arg Asp Pro Gly Val Ile Ser Ser Val Met Asp Glu Met Leu Asn 
    290                 295                 300                 


Tyr Arg Asp Pro Asp Gly Ile Met Gln Thr Tyr Phe Asp Asp Gly Arg 
305                 310                 315                 320 


Gln Arg Leu Asp Pro Phe Val Asn Val Asn Val Leu Thr Phe Phe Tyr 
                325                 330                 335     


Thr Asn Gly Arg Gly His Glu Leu Asp Gln Cys Leu Thr Trp Val Arg 
            340                 345                 350         


Glu Val Leu Leu Tyr Arg Ala Tyr Leu Gly Gly Ser Arg Tyr Tyr Pro 
        355                 360                 365             


Ser Ala Asp Cys Phe Leu Tyr Phe Ile Ser Arg Leu Phe Ala Cys Thr 
    370                 375                 380                 


Asn Asp Pro Val Leu His His Gln Leu Lys Pro Leu Phe Val Glu Arg 
385                 390                 395                 400 


Val Gln Glu Gln Ile Gly Val Glu Gly Asp Ala Leu Glu Leu Ala Phe 
                405                 410                 415     


Arg Leu Leu Val Cys Ala Ser Leu Asp Val Gln Asn Ala Ile Asp Met 
            420                 425                 430         


Arg Arg Leu Leu Glu Met Gln Cys Glu Asp Gly Gly Trp Glu Gly Gly 
        435                 440                 445             


Asn Leu Tyr Arg Phe Gly Thr Thr Gly Leu Lys Val Thr Asn Arg Gly 
    450                 455                 460                 


Leu Thr Thr Ala Ala Ala Val Gln Ala Ile Glu Ala Ser Gln Arg Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Ser Pro Ser Val Glu Ser Thr Lys Ser Pro Ile Thr 
                485                 490                 495     


Pro Val Thr Pro Met Leu Glu Val Pro Ser Leu Gly Leu Ser Ile Ser 
            500                 505                 510         


Arg Pro Ser Ser Pro Leu Leu Gly Tyr Phe Arg Leu Pro Trp Lys Lys 
        515                 520                 525             


Ser Ala Glu Val His 
    530             


<210>  35
<211>  1584
<212>  DNA
<213>  Dichomitus squalens


<220>
<221>  misc_feature
<223>  XP_007369631.1_E. coli optimized

<400>  35
atggcgagca tccaccgtcg ttacaccacc ctgattctgg acctgggtga tgttctgttt       60

cgttggagcc cgaagaccga gaccgcgatc ccgccgcagc aactgaaaga cattctgagc      120

agcgtgacct ggttcgagta cgaacgtggc cgtctgagcc aggaagcgtg ctatgaacgt      180

tgcgcggagg aatttaagat cgaggcgagc gttattgcgg aagcgttcaa acaagcgcgt      240

ggtagcctgc gtccgaacga ggaatttatc gcgctgattc gtgacctgcg tcgtgagatg      300

cacggcgatc tgaccgtgct ggcgctgagc aacatcagcc tgccggacta cgaatatatt      360

atgagcctga gcagcgactg gaccaccgtt ttcgatcgtg tgtttccgag cgcgctggtt      420

ggtgagcgta agccgcacct gggctgctat cgtaaagtga tcagcgagat gaacctggaa      480

ccgcagacca ccgtgttcgt tgacgataag ctggataacg ttgcgagcgc gcgtagcctg      540

ggtatgcatg gtattgtttt cgacaaccag gcgaacgtgt ttcgtcaact gcgtaacatc      600

ttcggtgatc cgattcgtcg tggccaagag tacctgcgtg gtcacgcggg caaactggaa      660

agcagcaccg acaacggtct gatcttcgag gaaaacttta cccagctgat catttatgag      720

ctgacccaag atcgtaccct gattagcctg agcgaatgcc cgcgtacctg gaacttcttt      780

cgtggcgagc cgctgttcag cgaaaccttc ccggacgacg ttgacaccac cagcgttgcg      840

ctgaccgtgc tgcagccgga ccgtgcgctg gttaacagcg tgctggatga gatgctggaa      900

tacgtggacg cggatggtat catgcaaacc tattttgacc gtagccgtcc gcgtatggat      960

ccgtttgtgt gcgttaacgt gctgagcctg ttctacgaga acggtcgtgg ccacgaactg     1020

ccgcgtaccc tggactgggt ttacgaggtg ctgctgcacc gtgcgtatca cggtggcagc     1080

cgttactatc tgagcccgga ttgcttcctg ttctttatga gccgtctgct gaaacgtgcg     1140

gatgatccgg cggttcaggc gcgtctgcgt ccgctgtttg ttgagcgtgt gaacgaacgt     1200

gttggtgcgg cgggtgacag catggatctg gcgttccgta tcctggcggc ggcgagcgtt     1260

ggtgtgcagt gcccgcgtga cctggaacgt ctgaccgcgg gtcaatgcga tgatggtggc     1320

tgggatctgt gctggttcta cgtttttggt agcaccggcg tgaaagcggg taaccgtggc     1380

ctgaccaccg cgctggcggt gaccgcgatt caaaccgcga ttggtcgtcc gccgagcccg     1440

agcccgagcg cggcgagcag cagctttcgt ccgagcagcc cgtataaatt cctgggtatc     1500

agccgtccgg cgagcccgat tcgttttggt gacctgctgc gtccgtggcg taagatgagc     1560

cgtagcaacc tgaaaagcca ataa                                            1584


<210>  36
<211>  527
<212>  PRT
<213>  Dichomitus squalens


<220>
<221>  MISC_FEATURE
<223>  XP_007369631.1_amino acid sequence

<400>  36

Met Ala Ser Ile His Arg Arg Tyr Thr Thr Leu Ile Leu Asp Leu Gly 
1               5                   10                  15      


Asp Val Leu Phe Arg Trp Ser Pro Lys Thr Glu Thr Ala Ile Pro Pro 
            20                  25                  30          


Gln Gln Leu Lys Asp Ile Leu Ser Ser Val Thr Trp Phe Glu Tyr Glu 
        35                  40                  45              


Arg Gly Arg Leu Ser Gln Glu Ala Cys Tyr Glu Arg Cys Ala Glu Glu 
    50                  55                  60                  


Phe Lys Ile Glu Ala Ser Val Ile Ala Glu Ala Phe Lys Gln Ala Arg 
65                  70                  75                  80  


Gly Ser Leu Arg Pro Asn Glu Glu Phe Ile Ala Leu Ile Arg Asp Leu 
                85                  90                  95      


Arg Arg Glu Met His Gly Asp Leu Thr Val Leu Ala Leu Ser Asn Ile 
            100                 105                 110         


Ser Leu Pro Asp Tyr Glu Tyr Ile Met Ser Leu Ser Ser Asp Trp Thr 
        115                 120                 125             


Thr Val Phe Asp Arg Val Phe Pro Ser Ala Leu Val Gly Glu Arg Lys 
    130                 135                 140                 


Pro His Leu Gly Cys Tyr Arg Lys Val Ile Ser Glu Met Asn Leu Glu 
145                 150                 155                 160 


Pro Gln Thr Thr Val Phe Val Asp Asp Lys Leu Asp Asn Val Ala Ser 
                165                 170                 175     


Ala Arg Ser Leu Gly Met His Gly Ile Val Phe Asp Asn Gln Ala Asn 
            180                 185                 190         


Val Phe Arg Gln Leu Arg Asn Ile Phe Gly Asp Pro Ile Arg Arg Gly 
        195                 200                 205             


Gln Glu Tyr Leu Arg Gly His Ala Gly Lys Leu Glu Ser Ser Thr Asp 
    210                 215                 220                 


Asn Gly Leu Ile Phe Glu Glu Asn Phe Thr Gln Leu Ile Ile Tyr Glu 
225                 230                 235                 240 


Leu Thr Gln Asp Arg Thr Leu Ile Ser Leu Ser Glu Cys Pro Arg Thr 
                245                 250                 255     


Trp Asn Phe Phe Arg Gly Glu Pro Leu Phe Ser Glu Thr Phe Pro Asp 
            260                 265                 270         


Asp Val Asp Thr Thr Ser Val Ala Leu Thr Val Leu Gln Pro Asp Arg 
        275                 280                 285             


Ala Leu Val Asn Ser Val Leu Asp Glu Met Leu Glu Tyr Val Asp Ala 
    290                 295                 300                 


Asp Gly Ile Met Gln Thr Tyr Phe Asp Arg Ser Arg Pro Arg Met Asp 
305                 310                 315                 320 


Pro Phe Val Cys Val Asn Val Leu Ser Leu Phe Tyr Glu Asn Gly Arg 
                325                 330                 335     


Gly His Glu Leu Pro Arg Thr Leu Asp Trp Val Tyr Glu Val Leu Leu 
            340                 345                 350         


His Arg Ala Tyr His Gly Gly Ser Arg Tyr Tyr Leu Ser Pro Asp Cys 
        355                 360                 365             


Phe Leu Phe Phe Met Ser Arg Leu Leu Lys Arg Ala Asp Asp Pro Ala 
    370                 375                 380                 


Val Gln Ala Arg Leu Arg Pro Leu Phe Val Glu Arg Val Asn Glu Arg 
385                 390                 395                 400 


Val Gly Ala Ala Gly Asp Ser Met Asp Leu Ala Phe Arg Ile Leu Ala 
                405                 410                 415     


Ala Ala Ser Val Gly Val Gln Cys Pro Arg Asp Leu Glu Arg Leu Thr 
            420                 425                 430         


Ala Gly Gln Cys Asp Asp Gly Gly Trp Asp Leu Cys Trp Phe Tyr Val 
        435                 440                 445             


Phe Gly Ser Thr Gly Val Lys Ala Gly Asn Arg Gly Leu Thr Thr Ala 
    450                 455                 460                 


Leu Ala Val Thr Ala Ile Gln Thr Ala Ile Gly Arg Pro Pro Ser Pro 
465                 470                 475                 480 


Ser Pro Ser Ala Ala Ser Ser Ser Phe Arg Pro Ser Ser Pro Tyr Lys 
                485                 490                 495     


Phe Leu Gly Ile Ser Arg Pro Ala Ser Pro Ile Arg Phe Gly Asp Leu 
            500                 505                 510         


Leu Arg Pro Trp Arg Lys Met Ser Arg Ser Asn Leu Lys Ser Gln 
        515                 520                 525         


<210>  37
<211>  1584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  XP_007369631.1_mutant of class II motif_ E.coli optimized

<400>  37
atggcgagca tccaccgtcg ttacaccacc ctgattctgg acctgggtga tgttctgttt       60

cgttggagcc cgaagaccga gaccgcgatc ccgccgcagc aactgaaaga cattctgagc      120

agcgtgacct ggttcgagta cgaacgtggc cgtctgagcc aggaagcgtg ctatgaacgt      180

tgcgcggagg aatttaagat cgaggcgagc gttattgcgg aagcgttcaa acaagcgcgt      240

ggtagcctgc gtccgaacga ggaatttatc gcgctgattc gtgacctgcg tcgtgagatg      300

cacggcgatc tgaccgtgct ggcgctgagc aacatcagcc tgccggacta cgaatatatt      360

atgagcctga gcagcgactg gaccaccgtt ttcgatcgtg tgtttccgag cgcgctggtt      420

ggtgagcgta agccgcacct gggctgctat cgtaaagtga tcagcgagat gaacctggaa      480

ccgcagacca ccgtgttcgt tgacgataag ctggataacg ttgcgagcgc gcgtagcctg      540

ggtatgcatg gtattgtttt cgacaaccag gcgaacgtgt ttcgtcaact gcgtaacatc      600

ttcggtgatc cgattcgtcg tggccaagag tacctgcgtg gtcacgcggg caaactggaa      660

agcagcaccg acaacggtct gatcttcgag gaaaacttta cccagctgat catttatgag      720

ctgacccaag atcgtaccct gattagcctg agcgaatgcc cgcgtacctg gaacttcttt      780

cgtggcgagc cgctgttcag cgaaaccttc ccggcggcgg ttgcgaccac cagcgttgcg      840

ctgaccgtgc tgcagccgga ccgtgcgctg gttaacagcg tgctggatga gatgctggaa      900

tacgtggacg cggatggtat catgcaaacc tattttgacc gtagccgtcc gcgtatggat      960

ccgtttgtgt gcgttaacgt gctgagcctg ttctacgaga acggtcgtgg ccacgaactg     1020

ccgcgtaccc tggactgggt ttacgaggtg ctgctgcacc gtgcgtatca cggtggcagc     1080

cgttactatc tgagcccgga ttgcttcctg ttctttatga gccgtctgct gaaacgtgcg     1140

gatgatccgg cggttcaggc gcgtctgcgt ccgctgtttg ttgagcgtgt gaacgaacgt     1200

gttggtgcgg cgggtgacag catggatctg gcgttccgta tcctggcggc ggcgagcgtt     1260

ggtgtgcagt gcccgcgtga cctggaacgt ctgaccgcgg gtcaatgcga tgatggtggc     1320

tgggatctgt gctggttcta cgtttttggt agcaccggcg tgaaagcggg taaccgtggc     1380

ctgaccaccg cgctggcggt gaccgcgatt caaaccgcga ttggtcgtcc gccgagcccg     1440

agcccgagcg cggcgagcag cagctttcgt ccgagcagcc cgtataaatt cctgggtatc     1500

agccgtccgg cgagcccgat tcgttttggt gacctgctgc gtccgtggcg taagatgagc     1560

cgtagcaacc tgaaaagcca ataa                                            1584


<210>  38
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XP_007369631.1_mutant of class II motif

<400>  38

Met Ala Ser Ile His Arg Arg Tyr Thr Thr Leu Ile Leu Asp Leu Gly 
1               5                   10                  15      


Asp Val Leu Phe Arg Trp Ser Pro Lys Thr Glu Thr Ala Ile Pro Pro 
            20                  25                  30          


Gln Gln Leu Lys Asp Ile Leu Ser Ser Val Thr Trp Phe Glu Tyr Glu 
        35                  40                  45              


Arg Gly Arg Leu Ser Gln Glu Ala Cys Tyr Glu Arg Cys Ala Glu Glu 
    50                  55                  60                  


Phe Lys Ile Glu Ala Ser Val Ile Ala Glu Ala Phe Lys Gln Ala Arg 
65                  70                  75                  80  


Gly Ser Leu Arg Pro Asn Glu Glu Phe Ile Ala Leu Ile Arg Asp Leu 
                85                  90                  95      


Arg Arg Glu Met His Gly Asp Leu Thr Val Leu Ala Leu Ser Asn Ile 
            100                 105                 110         


Ser Leu Pro Asp Tyr Glu Tyr Ile Met Ser Leu Ser Ser Asp Trp Thr 
        115                 120                 125             


Thr Val Phe Asp Arg Val Phe Pro Ser Ala Leu Val Gly Glu Arg Lys 
    130                 135                 140                 


Pro His Leu Gly Cys Tyr Arg Lys Val Ile Ser Glu Met Asn Leu Glu 
145                 150                 155                 160 


Pro Gln Thr Thr Val Phe Val Asp Asp Lys Leu Asp Asn Val Ala Ser 
                165                 170                 175     


Ala Arg Ser Leu Gly Met His Gly Ile Val Phe Asp Asn Gln Ala Asn 
            180                 185                 190         


Val Phe Arg Gln Leu Arg Asn Ile Phe Gly Asp Pro Ile Arg Arg Gly 
        195                 200                 205             


Gln Glu Tyr Leu Arg Gly His Ala Gly Lys Leu Glu Ser Ser Thr Asp 
    210                 215                 220                 


Asn Gly Leu Ile Phe Glu Glu Asn Phe Thr Gln Leu Ile Ile Tyr Glu 
225                 230                 235                 240 


Leu Thr Gln Asp Arg Thr Leu Ile Ser Leu Ser Glu Cys Pro Arg Thr 
                245                 250                 255     


Trp Asn Phe Phe Arg Gly Glu Pro Leu Phe Ser Glu Thr Phe Pro Ala 
            260                 265                 270         


Ala Val Ala Thr Thr Ser Val Ala Leu Thr Val Leu Gln Pro Asp Arg 
        275                 280                 285             


Ala Leu Val Asn Ser Val Leu Asp Glu Met Leu Glu Tyr Val Asp Ala 
    290                 295                 300                 


Asp Gly Ile Met Gln Thr Tyr Phe Asp Arg Ser Arg Pro Arg Met Asp 
305                 310                 315                 320 


Pro Phe Val Cys Val Asn Val Leu Ser Leu Phe Tyr Glu Asn Gly Arg 
                325                 330                 335     


Gly His Glu Leu Pro Arg Thr Leu Asp Trp Val Tyr Glu Val Leu Leu 
            340                 345                 350         


His Arg Ala Tyr His Gly Gly Ser Arg Tyr Tyr Leu Ser Pro Asp Cys 
        355                 360                 365             


Phe Leu Phe Phe Met Ser Arg Leu Leu Lys Arg Ala Asp Asp Pro Ala 
    370                 375                 380                 


Val Gln Ala Arg Leu Arg Pro Leu Phe Val Glu Arg Val Asn Glu Arg 
385                 390                 395                 400 


Val Gly Ala Ala Gly Asp Ser Met Asp Leu Ala Phe Arg Ile Leu Ala 
                405                 410                 415     


Ala Ala Ser Val Gly Val Gln Cys Pro Arg Asp Leu Glu Arg Leu Thr 
            420                 425                 430         


Ala Gly Gln Cys Asp Asp Gly Gly Trp Asp Leu Cys Trp Phe Tyr Val 
        435                 440                 445             


Phe Gly Ser Thr Gly Val Lys Ala Gly Asn Arg Gly Leu Thr Thr Ala 
    450                 455                 460                 


Leu Ala Val Thr Ala Ile Gln Thr Ala Ile Gly Arg Pro Pro Ser Pro 
465                 470                 475                 480 


Ser Pro Ser Ala Ala Ser Ser Ser Phe Arg Pro Ser Ser Pro Tyr Lys 
                485                 490                 495     


Phe Leu Gly Ile Ser Arg Pro Ala Ser Pro Ile Arg Phe Gly Asp Leu 
            500                 505                 510         


Leu Arg Pro Trp Arg Lys Met Ser Arg Ser Asn Leu Lys Ser Gln 
        515                 520                 525         


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif_mutated_BtHAD

<400>  39

Pro Asp Ala Leu Ala Ser Thr Ser 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif_mutated_SmHAD1 + SmHAD2

<400>  40

Pro Pro Ala Ile Ala Thr Met Ser 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif_mutated_EMD37666

<400>  41

Pro Ala Ala Leu Ala Thr Thr Ser 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif_mutated_XP_007369631

<400>  42

Pro Ala Ala Val Ala Thr Thr Ser 
1               5               


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QW motif_mutated_BtHAD

<400>  43

Gln Asn Val Ala Gly Ser Trp 
1               5           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QW motif_mutated_SmHAD1+ SmHAD2

<400>  44

Gln Asn Ala Ala Gly Ser Trp 
1               5           


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class I synthase motif DDxx(D/E)


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be D or E

<400>  45

Asp Asp Xaa Xaa Xaa 
1               5   


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif PxDxD(T/S)(T/M)S


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be T or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be T or M

<400>  46

Pro Xaa Asp Xaa Asp Xaa Xaa Ser 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif PDDLDSTS

<400>  47

Pro Asp Asp Leu Asp Ser Thr Ser 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif PDDLDTTS

<400>  48

Pro Asp Asp Leu Asp Thr Thr Ser 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif PPDIDTMS

<400>  49

Pro Pro Asp Ile Asp Thr Met Ser 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif PNDIDTMS

<400>  50

Pro Asn Asp Ile Asp Thr Thr Ser 
1               5               


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QW motif


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Gln Xaa Xaa Asp Gly Xaa Trp 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QW motif QNVDGSW

<400>  52

Gln Asn Val Asp Gly Ser Trp 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QW motif QCDDGGW

<400>  53

Gln Cys Asp Asp Gly Gly Trp 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QW motif QSSDGGW

<400>  54

Gln Ser Ser Asp Gly Gly Trp 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QW motif QNEDGSW

<400>  55

Gln Asn Glu Asp Gly Ser Trp 
1               5           


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 1 Lxxxx(W/F)xxYxxG


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be W or F

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  56

Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Gly 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 1 LRSHIWFNYSMG

<400>  57

Leu Arg Ser His Ile Trp Phe Asn Tyr Ser Met Gly 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 1 LRSATWAAYECG

<400>  58

Leu Arg Ser Ala Thr Trp Ala Ala Tyr Glu Cys Gly 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 1 LRTPTWGKYECG

<400>  59

Leu Arg Thr Pro Thr Trp Gly Lys Tyr Glu Cys Gly 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 1 LQHSSFLAYSCG

<400>  60

Leu Gln His Ser Ser Phe Leu Ala Tyr Ser Cys Gly 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 1 LRxxTWxxYECG


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  61

Leu Arg Xaa Xaa Thr Trp Xaa Xaa Tyr Glu Cys Gly 
1               5                   10          


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 2 YxDxxRxRVD(P/A)V(V/A)xxN


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be P or A

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa can be V or A

<220>
<221>  MISC_FEATURE
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  62

Tyr Xaa Asp Xaa Xaa Arg Xaa Arg Val Asp Xaa Val Xaa Xaa Xaa Asn 
1               5                   10                  15      


<210>  63
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 2 YFDPLRLRVDPVAATN

<400>  63

Tyr Phe Asp Pro Leu Arg Leu Arg Val Asp Pro Val Ala Ala Thr Asn 
1               5                   10                  15      


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 2 YFDETRPRVDAVVNVN

<400>  64

Tyr Phe Asp Glu Thr Arg Pro Arg Val Asp Ala Val Val Asn Val Asn 
1               5                   10                  15      


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 2 YFDKTRPRVDPVVCVN

<400>  65

Tyr Phe Asp Lys Thr Arg Pro Arg Val Asp Pro Val Val Cys Val Asn 
1               5                   10                  15      


<210>  66
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 2 YLDVERPRVDPVVIAN

<400>  66

Tyr Leu Asp Val Glu Arg Pro Arg Val Asp Pro Val Val Ile Ala Asn 
1               5                   10                  15      


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 2 YLDLERPRVDPVVIAN

<400>  67

Tyr Leu Asp Leu Glu Arg Pro Arg Val Asp Pro Val Val Ile Ala Asn 
1               5                   10                  15      


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 2 Y(F/L)Dx(T/E)RPRVD(P/A)VVx(A/V)N


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be F or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be T or E

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be P or A

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa can be A or V

<400>  68

Tyr Xaa Asp Xaa Xaa Arg Pro Arg Val Asp Xaa Val Val Xaa Xaa Asn 
1               5                   10                  15      


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 3 GTx(Y/F)YxxxExFL(Y/F)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Y or F

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa can be Y or F

<400>  69

Gly Thr Xaa Xaa Tyr Xaa Xaa Xaa Glu Xaa Phe Leu Xaa 
1               5                   10              


<210>  70
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 3 GTLYYRTPEAFLY

<400>  70

Gly Thr Leu Tyr Tyr Arg Thr Pro Glu Ala Phe Leu Tyr 
1               5                   10              


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 3 GTLFYYHAESFLY

<400>  71

Gly Thr Leu Phe Tyr Tyr His Ala Glu Ser Phe Leu Tyr 
1               5                   10              


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 3 GTRYYLSQEDFLF

<400>  72

Gly Thr Arg Tyr Tyr Leu Ser Gln Glu Asp Phe Leu Phe 
1               5                   10              


<210>  73
<211>  1755
<212>  DNA
<213>  Dryopteris fragrans


<220>
<221>  misc_feature
<223>  DfHAD_wt_nucleic acid sequence

<400>  73
atggagttct ctgcctctgc tcctcctcct aggctagcca gtgtcataat attggagcct       60

ctcggcttcc tcctcacacc acactactcc tctcagcttc ccaaaaagct gctccgtcgc      120

ctgttgtgca ctagaatctg gcacaggtat cagcgaggcc gccttcgcct gcgtgacgct      180

gctatgctgc tcgcccagct cccattccta gctgtgtctg atcacccctg ggctctggac      240

aatctcgcaa gcctgctccg ccccacagct gtgcgtgcgg tgccatggat gctgctgctg      300

ctcgacttcc tacgagacga gctccatctg aaggtagtct gcgcgaccaa ctcctcccca      360

gaagagctgc aagagctgcg ccaccagttt ccggccctct ttgccaaggt cgatgccacc      420

gtttcttcag gcgaggaggg cgtgggcaag ccgtccgtgc gcttcctgca ggctgcgttg      480

gacaaagccg gtgtccacgc gcagcaaacc ttgtatcttg actcttttga cagcttggag      540

accatcatgg ctgcacgctc tcttggcatg catgcactat ctgtagagcc atgccacatt      600

gatgagctca ccgccagggc ctcttccggc cagctaagag atgcacagct tataaggcgt      660

attgtgtgcg ccatgcacgg gccagcagta tctgcagttg tgtcgggcag tatcacatcg      720

tccggcccac agacagcaaa gatcgaggaa ttgccaacag ctgctgatag tcatctccgc      780

agcgcagctc tcacttctgc tcagcagttt ttcctcaaag ttattgctcc acatcgtcct      840

gagaagccat tcgtccagct tccatctctc acctcggagg gcatccgaat atacgacacc      900

tttgcacagt ttgtcatagc cgacctgctc gacgacaccc gcttcctacc catgcaatct      960

cctcctccca atgggctcat cacctttgtt aacccaagcg cgtaccttgc tgatgatata     1020

aagaatggca acagccatat tgtcccgggt gtgcaatttt acgcatccga tgcgtgcact     1080

ctcatcgaca tcccacatga cctagacacc acctccgttg gcttgtcagt actgcacaag     1140

tttggaaagg tggacaagga cacactcaac aaagtgctag acagaatgct cgagcaagtg     1200

agtgaagacg acggcattct gcaggtgtat tttgatgtgg agcgtccgcg catcgatcca     1260

gttgtggtgg caaacacggt gtttctgttc cacttgggaa agagagggca tgaggtggcg     1320

aggagtgaga agtttgtgga gagtgtgctg ctgcagaggg catacgaaga agggacgttg     1380

tattacaacc tgggggaagc atttttggtg agtgtggcga ggctggtgca cgagtttaag     1440

gagcacttta caaggagcgg catgaggagg gcactggagg agaggctaag agagcgggca     1500

agggcgggca tgcaagagag ggatgatgcg ctggcgctag ccatgcgcat tcgtgcatgc     1560

gctttgtgtg gcctggccgg agagggcctc acaaaagcag cagagcagga gcttttgcgc     1620

ctgcagtgca agtccaaggg ctgttggggg tgccaccctt tctatcgcaa tggcagtaat     1680

gtgctcagct ggatcggcag tgaggccctt accactgctt acgctattgc tgcgctacag     1740

cccattgata tttaa                                                      1755


<210>  74
<211>  591
<212>  PRT
<213>  Dryopteris fragrans


<220>
<221>  MISC_FEATURE
<223>  DfHAD_amino acid sequence

<400>  74

Met Glu Phe Ser Ala Ser Ala Pro Pro Pro Arg Leu Ala Ser Val Ile 
1               5                   10                  15      


Ile Leu Glu Pro Leu Gly Phe Leu Leu Thr Pro His Tyr Ser Ser Gln 
            20                  25                  30          


Leu Pro Lys Lys Leu Leu Arg Arg Leu Leu Cys Thr Arg Ile Trp His 
        35                  40                  45              


Arg Tyr Gln Arg Gly Arg Leu Arg Leu Arg Asp Ala Ala Met Leu Leu 
    50                  55                  60                  


Ala Gln Leu Pro Phe Leu Ala Val Ser Asp His Pro Trp Ala Leu Asp 
65                  70                  75                  80  


Asn Leu Ala Ser Leu Leu Arg Pro Thr Ala Val Arg Ala Val Pro Trp 
                85                  90                  95      


Met Leu Leu Leu Leu Asp Phe Leu Arg Asp Glu Leu His Leu Lys Val 
            100                 105                 110         


Val Cys Ala Thr Asn Ser Ser Pro Glu Glu Leu Gln Glu Leu Arg His 
        115                 120                 125             


Gln Phe Pro Ala Leu Phe Ala Lys Val Asp Ala Thr Val Ser Ser Gly 
    130                 135                 140                 


Glu Glu Gly Val Gly Lys Pro Ser Val Arg Phe Leu Gln Ala Ala Leu 
145                 150                 155                 160 


Asp Lys Ala Gly Val His Ala Gln Gln Thr Leu Tyr Leu Asp Ser Phe 
                165                 170                 175     


Asp Ser Leu Glu Thr Ile Met Ala Ala Arg Ser Leu Gly Met His Ala 
            180                 185                 190         


Leu Ser Val Glu Pro Cys His Ile Asp Glu Leu Thr Ala Arg Ala Ser 
        195                 200                 205             


Ser Gly Gln Leu Arg Asp Ala Gln Leu Ile Arg Arg Ile Val Cys Ala 
    210                 215                 220                 


Met His Gly Pro Ala Val Ser Ala Val Val Ser Gly Ser Ile Thr Ser 
225                 230                 235                 240 


Ser Gly Pro Gln Thr Ala Lys Ile Glu Glu Leu Pro Thr Ala Ala Asp 
                245                 250                 255     


Ser His Leu Arg Ser Ala Ala Leu Thr Ser Ala Gln Gln Phe Phe Leu 
            260                 265                 270         


Lys Val Ile Ala Pro His Arg Pro Glu Lys Pro Phe Val Gln Leu Pro 
        275                 280                 285             


Ser Leu Thr Ser Glu Gly Ile Arg Ile Tyr Asp Thr Phe Ala Gln Phe 
    290                 295                 300                 


Val Ile Ala Asp Leu Leu Asp Asp Thr Arg Phe Leu Pro Met Gln Ser 
305                 310                 315                 320 


Pro Pro Pro Asn Gly Leu Ile Thr Phe Val Asn Pro Ser Ala Tyr Leu 
                325                 330                 335     


Ala Asp Asp Ile Lys Asn Gly Asn Ser His Ile Val Pro Gly Val Gln 
            340                 345                 350         


Phe Tyr Ala Ser Asp Ala Cys Thr Leu Ile Asp Ile Pro His Asp Leu 
        355                 360                 365             


Asp Thr Thr Ser Val Gly Leu Ser Val Leu His Lys Phe Gly Lys Val 
    370                 375                 380                 


Asp Lys Asp Thr Leu Asn Lys Val Leu Asp Arg Met Leu Glu Gln Val 
385                 390                 395                 400 


Ser Glu Asp Asp Gly Ile Leu Gln Val Tyr Phe Asp Val Glu Arg Pro 
                405                 410                 415     


Arg Ile Asp Pro Val Val Val Ala Asn Thr Val Phe Leu Phe His Leu 
            420                 425                 430         


Gly Lys Arg Gly His Glu Val Ala Arg Ser Glu Lys Phe Val Glu Ser 
        435                 440                 445             


Val Leu Leu Gln Arg Ala Tyr Glu Glu Gly Thr Leu Tyr Tyr Asn Leu 
    450                 455                 460                 


Gly Glu Ala Phe Leu Val Ser Val Ala Arg Leu Val His Glu Phe Lys 
465                 470                 475                 480 


Glu His Phe Thr Arg Ser Gly Met Arg Arg Ala Leu Glu Glu Arg Leu 
                485                 490                 495     


Arg Glu Arg Ala Arg Ala Gly Met Gln Glu Arg Asp Asp Ala Leu Ala 
            500                 505                 510         


Leu Ala Met Arg Ile Arg Ala Cys Ala Leu Cys Gly Leu Ala Gly Glu 
        515                 520                 525             


Gly Leu Thr Lys Ala Ala Glu Gln Glu Leu Leu Arg Leu Gln Cys Lys 
    530                 535                 540                 


Ser Lys Gly Cys Trp Gly Cys His Pro Phe Tyr Arg Asn Gly Ser Asn 
545                 550                 555                 560 


Val Leu Ser Trp Ile Gly Ser Glu Ala Leu Thr Thr Ala Tyr Ala Ile 
                565                 570                 575     


Ala Ala Leu Gln Pro Ile Asp Ile Ile Asp Phe Met Phe Ala Met 
            580                 585                 590     


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  class II synthase motif DxDxxS


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

Asp Xaa Asp Xaa Xaa Ser 
1               5       


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QW motif QxxxxxW


<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  76

Gln Xaa Xaa Xaa Xaa Xaa Trp 
1               5           


