                         SEQUENCE LISTING

<110>  WUXI BIOLOGICS (SHANGHAI) CO., LTD.
       WUXI BIOLOGICS IRELAND LIMITED
 
<120>  A NOVEL ANTI-CD3/ANTI-EGFR BISPECIFIC ANTIBODY AND USES THEREOF

<130>  IEC196135PCT

<150>  PCT/CN2019/121869
<151>  2019-11-29

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  1

Gly Phe Ala Phe Thr Asp Tyr Tyr Ile His 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  2

Trp Ile Ser Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  3

Asp Gly Tyr Ser Leu Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  4

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  5

Trp Ala Ser Thr Arg Gln Ser 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  6

Thr Gln Ser His Thr Leu Arg Thr 
1               5               


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  7

Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr 
1               5                   10          


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  8

His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  9

Asp Arg Val Thr Gly Ala Phe Asp Ile 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  10

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  11

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  12

Gln His Phe Asp His Leu Pro Leu Ala 
1               5                   


<210>  13
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ala Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Thr Gln 
                85                  90                  95      


Ser His Thr Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val 
        115         


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  17
caggtgcagc ttgtgcagtc tggggcagaa gtgaagaagc ctgggtctag tgtcaaggtg       60

tcatgcaagg ctagcgggtt cgcctttact gactactaca tccactgggt gcggcaggct      120

cccggacaag ggttggagtg gatgggatgg atctccccag gcaatgtcaa cacaaagtac      180

aacgagaact tcaaaggccg cgtcaccatt accgccgaca agagcacctc cacagcctac      240

atggagctgt ccagcctcag aagcgaggac actgccgtct actactgtgc cagggatggg      300

tactccctgt attactttga ttactggggc cagggcacac tggtgacagt gagctcc         357


<210>  18
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  18
gatatcgtga tgacccagag cccagactcc cttgctgtct ccctcggcga aagagcaacc       60

atcaactgca agagctccca aagcctgctg aactccagga ccaggaagaa ttacctggcc      120

tggtatcagc agaagcccgg ccagcctcct aagctgctca tctactgggc ctccacccgg      180

cagtctgggg tgcccgatcg gtttagtgga tctgggagcg ggacagactt cacattgaca      240

attagctcac tgcaggccga ggacgtggcc gtctactact gtactcagag ccacactctc      300

cgcacattcg gcggagggac taaagtggag attaag                                336


<210>  19
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  19
caggtgcaac tgcaggaaag cggaccagga cttgtgaagc cctctgagac tttgtccctg       60

acctgtaccg tctccggggg ctctgtcagt tcaggggatt actactggac atggatcagg      120

cagagtcctg ggaaaggcct ggagtggatt gggcacatct actactcagg gaacaccaac      180

tacaatccca gcctcaagag cagactgacc atcagcattg acacctccaa gacacagttc      240

tccctgaagc tcagcagcgt gactgccgcc gacacagcaa tctactattg cgtgcgcgac      300

cgggtgacag gcgcttttga tatttggggc cagggcacaa tggtcactgt g               351


<210>  20
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  20
gatatccaga tgacccagtc cccttcctcc ttgtccgcaa gtgtgggaga tagagtgacc       60

atcacatgcc aggcttctca ggacatctct aactacctga actggtacca acagaagccc      120

ggcaaggccc ctaagctcct tatctacgac gcctcaaatc tggagaccgg agtcccaagc      180

aggttcagcg gcagcgggag cgggacagat ttcactttta caattagctc cctccagcca      240

gaagacattg ccacatattt ctgtcagcac tttgaccatc tgcccctggc ctttgggggc      300

gggactaaag tggagattaa g                                                321


<210>  21
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a second light chain

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Pro Asp Ile Gln Asn 
            100                 105                 110         


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
        115                 120                 125             


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Gln Val Ser Gln 
    130                 135                 140                 


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met 
145                 150                 155                 160 


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Gln Lys 
                165                 170                 175     


Ser Asp Phe Ala Cys Ala Asn Ala Phe Gln Asn Ser Ile Ile Pro Glu 
            180                 185                 190         


Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200         


<210>  22
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a first light chain

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Thr Gln 
                85                  90                  95      


Ser His Thr Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  23
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a first heavy chain

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ala Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Ser Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Cys Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  24
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a second heavy chain

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
        115                 120                 125             


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
    130                 135                 140                 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
145                 150                 155                 160 


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
                165                 170                 175     


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Gln Asp Ser Arg Tyr 
            180                 185                 190         


Ala Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
        195                 200                 205             


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
    210                 215                 220                 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
225                 230                 235                 240 


Ala Glu Ala Trp Gly Arg Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            420                 425                 430         


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Leu Gly Lys 
465                 470         


<210>  25
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a second light chain

<400>  25
gatatccaga tgacccagtc cccttcctcc ttgtccgcaa gtgtgggaga tagagtgacc       60

atcacatgcc aggcttctca ggacatctct aactacctga actggtacca acagaagccc      120

ggcaaggccc ctaagctcct tatctacgac gcctcaaatc tggagaccgg agtcccaagc      180

aggttcagcg gcagcgggag cgggacagat ttcactttta caattagctc cctccagcca      240

gaagacattg ccacatattt ctgtcagcac tttgaccatc tgcccctggc ctttgggggc      300

gggactaaag tggagattaa gcccgacatc cagaaccccg accccgccgt gtaccagctg      360

agagacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc      420

caggtgagcc agagcaagga ctccgacgtg tatatcaccg acaagtgcgt gctggacatg      480

aggagcatgg acttcaagag caacagcgcc gtggcctgga gccagaagag cgacttcgcc      540

tgcgccaacg ccttccagaa cagcatcatc cccgaggaca ccttcttccc cagccccgag      600

agcagc                                                                 606


<210>  26
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a first light chain

<400>  26
gatatcgtga tgacccagag cccagactcc cttgctgtct ccctcggcga aagagcaacc       60

atcaactgca agagctccca aagcctgctg aactccagga ccaggaagaa ttacctggcc      120

tggtatcagc agaagcccgg ccagcctcct aagctgctca tctactgggc ctccacccgg      180

cagtctgggg tgcccgatcg gtttagtgga tctgggagcg ggacagactt cacattgaca      240

attagctcac tgcaggccga ggacgtggcc gtctactact gtactcagag ccacactctc      300

cgcacattcg gcggagggac taaagtggag attaagcgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  27
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a first heavy chain

<400>  27
caggtgcagc ttgtgcagtc tggggcagaa gtgaagaagc ctgggtctag tgtcaaggtg       60

tcatgcaagg ctagcgggtt cgcctttact gactactaca tccactgggt gcggcaggct      120

cccggacaag ggttggagtg gatgggatgg atctccccag gcaatgtcaa cacaaagtac      180

aacgagaact tcaaaggccg cgtcaccatt accgccgaca agagcacctc cacagcctac      240

atggagctgt ccagcctcag aagcgaggac actgccgtct actactgtgc cagggatggg      300

tactccctgt attactttga ttactggggc cagggcacac tggtgacagt gagctccgcg      360

tcgaccaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc atgcccagca cctgaggcag cagggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agttcaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaggt gtacaccctg cccccatgcc aggaggagat gaccaagaac     1080

caggtcagcc tgtggtgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca ggaggggaat     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc     1320

tccctgtctc tgggtaaa                                                   1338


<210>  28
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a second heavy chain

<400>  28
caggtgcaac tgcaggaaag cggaccagga cttgtgaagc cctctgagac tttgtccctg       60

acctgtaccg tctccggggg ctctgtcagt tcaggggatt actactggac atggatcagg      120

cagagtcctg ggaaaggcct ggagtggatt gggcacatct actactcagg gaacaccaac      180

tacaatccca gcctcaagag cagactgacc atcagcattg acacctccaa gacacagttc      240

tccctgaagc tcagcagcgt gactgccgcc gacacagcaa tctactattg cgtgcgcgac      300

cgggtgacag gcgcttttga tatttggggc cagggcacaa tggtcactgt gctggaggac      360

ctgaagaacg tgttccctcc cgaggtggcc gtgttcgaac ccagcgaggc cgagatcagc      420

cacacccaga aggccaccct ggtgtgtctg gccaccggct tctaccccga ccacgtggag      480

ctgagctggt gggtgaacgg caaggaggtg cacagcggcg tgtgtaccga ccctcagccc      540

ctgaaggagc agcccgccct gcaggacagc aggtacgccc tgagcagcag gctgagagtg      600

agcgccacct tctggcagaa ccccaggaac cacttcaggt gccaggtgca gttctacggc      660

ctgagcgaga acgacgagtg gacccaggac agggccaagc ccgtgaccca gatcgtgagc      720

gctgaggcct ggggcagata tggtccccca tgcccaccat gcccagcacc tgaggcagca      780

gggggaccat cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg      840

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc      900

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

ttcaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagag ccacaggtgt gcaccctgcc cccatcccag     1140

gaggagatga ccaagaacca ggtcagcctg agctgcgcgg tcaaaggctt ctaccccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctcgttagca ggctaaccgt ggacaagagc     1320

aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacacaga agagcctctc cctgtctctg ggtaaa                               1416


<210>  29
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta constant domain

<400>  29

Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu 
1               5                   10                  15      


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
            20                  25                  30          


Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val 
        35                  40                  45              


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu 
    50                  55                  60                  


Lys Glu Gln Pro Ala Leu Gln Asp Ser Arg Tyr Ala Leu Ser Ser Arg 
65                  70                  75                  80  


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
                85                  90                  95      


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
            100                 105                 110         


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
        115                 120                 125             


Arg 
    


<210>  30
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha constant domain

<400>  30

Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Gln Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Gln Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Gln Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
                85                  90                  95  


