﻿                         序列表

<110>  浙江工业大学

<120>  一种D-阿洛酮糖3-差向异构酶突变体及其应用

<160>  7

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  295
<212>  PRT
<213>  Rhizobiales bacterium

<400>  1
Met Lys His Gly Ile Tyr Tyr Ser Tyr Trp Glu Lys Glu Trp Ser Ala 
1               5                   10                  15      
Lys Phe Gly Pro Tyr Val Glu Lys Val Ala Lys Leu Gly Phe Asp Val 
            20                  25                  30          
Ile Glu Val Ala Ala His His Ile Asn Ser Tyr Ser Asp Ala Glu Leu 
        35                  40                  45              
Ala Ala Ile Arg Gln Ala Ser Lys Asp Asn Gly Ile Ile Leu Thr Ala 
    50                  55                  60                  
Gly Ile Gly Pro Thr Lys Gln Lys Asn Leu Ser Ser Pro Asp Ala Asp 
65                  70                  75                  80  
Val Arg Lys Ala Gly Lys Ala Phe Phe Glu Gln Thr Leu Thr Asn Val 
                85                  90                  95      
Ala Lys Leu Asp Ile Lys Ser Ile Gly Gly Ala Leu His Ser Tyr Trp 
            100                 105                 110         
Pro Val Asp Tyr Thr Gln Pro Val Asp Lys Ile Gly Asp Arg Ala Arg 
        115                 120                 125             
Gly Val Glu Gly Ile His Gly Ile Ala Asp Phe Ala Ser Asn Leu Gly 
    130                 135                 140                 
Ile Asn Leu Cys Ile Glu Val Leu Asn Arg Phe Glu Asn His Val Leu 
145                 150                 155                 160 
Asn Thr Ala Ala Glu Gly Val Ala Phe Val Lys Asp Val Gly Lys Ser 
                165                 170                 175     
Asn Val Lys Val Met Leu Asp Thr Phe His Met Asn Ile Glu Glu Asp 
            180                 185                 190         
Ser Phe Gly Asp Ala Ile Arg Thr Ala Gly Pro Leu Leu Gly His Phe 
        195                 200                 205             
His Thr Gly Glu Asn Asn Arg Arg Val Pro Gly Thr Gly Arg Ile Pro 
    210                 215                 220                 
Trp His Glu Ile Gly Leu Ala Leu Arg Glu Ile Asn Tyr Thr Gly Ala 
225                 230                 235                 240 
Val Val Met Glu Pro Phe Val Lys Thr Gly Gly Gly Ile Gly Ser Asp 
                245                 250                 255     
Ile Arg Val Trp Arg Asp Leu Ser Asn Gly Ala Thr Glu Ala Lys Leu 
            260                 265                 270         
Asp Glu Asp Ala Arg Asn Ser Leu Ala Phe Ser Arg Phe Val Leu Gly 
        275                 280                 285             
Ala His His His His His His 
    290                 295 

<210>  2
<211>  885
<212>  DNA
<213>  Rhizobiales bacterium

<400>  2
atgaagcatg gtatctatta cagttactgg gaaaaagaat ggagtgccaa attcggtccg        60
tatgtggaaa aagtggccaa actgggcttc gatgttattg aagtggccgc acatcatatt       120
aatagttata gcgatgcaga actggcagcc attcgtcagg ccagcaaaga taatggcatt       180
attctgaccg ccggcattgg cccgaccaaa cagaaaaatc tgagtagccc ggatgcagat       240
gtgcgcaaag ccggtaaagc attcttcgaa cagaccctga ccaatgtggc aaaactggat       300
attaaaagta tcggtggcgc actgcatagc tattggccgg ttgattatac ccagccggtg       360
gataaaattg gcgatcgcgc acgcggcgtt gaaggcattc atggcattgc cgacttcgca       420
agcaatctgg gcattaatct gtgtattgaa gttctgaatc gcttcgaaaa tcatgtgctg       480
aataccgccg cagaaggtgt tgcattcgtt aaagatgttg gcaaaagtaa tgtgaaagtg       540
atgctggata ccttccacat gaatattgaa gaagatagct tcggtgatgc aattcgcacc       600
gcaggcccgc tgctgggtca cttccatacc ggtgaaaata atcgccgtgt tccgggcacc       660
ggccgcattc cttggcatga aattggcctg gcactgcgcg aaattaatta taccggtgca       720
gttgtgatgg aaccgttcgt taaaaccggc ggcggtattg gcagtgatat tcgtgtgtgg       780
cgtgatctga gtaatggcgc caccgaagca aaactggacg aagatgcacg caatagtctg       840
gccttcagtc gcttcgttct gggtgcacat catcatcatc accat                       885

<210>  3
<211>  298
<212>  PRT
<213>  Martelella sp.

<400>  3
Met Lys Phe Gly Ile Tyr Tyr Ser Tyr Trp Glu Gln Glu Trp Ser Ala 
1               5                   10                  15      
Asp Cys Leu Arg His Val Glu Lys Val Ala Lys Leu Gly Phe Asp Val 
            20                  25                  30          
Ile Glu Ile Ala Ala His His Leu Asn Ser Phe Ser Pro Ala His Ile 
        35                  40                  45              
Asp Asp Ile Ala Arg Cys Ala Arg Asp Asn Asn Ile Ala Val Thr Ser 
    50                  55                  60                  
Gly Leu Gly Pro Ser Gln Glu Arg Asn Leu Ser Ser Pro Asp Ala Asp 
65                  70                  75                  80  
Ile Arg Lys Ala Gly Arg Ala Phe Phe Glu Glu Thr Leu Val Asn Ile 
                85                  90                  95      
Ala Lys Leu Asp Val His Ile Ile Gly Gly Ala Leu His Ser Tyr Trp 
            100                 105                 110         
Pro Val Asp Tyr Ser Gln Pro Val Asp Lys Glu Gly Asp Arg Ala Arg 
        115                 120                 125             
Gly Val Glu Gly Ile Ser Ser Leu Ala Asp Phe Ala Ala Asp Leu Gly 
    130                 135                 140                 
Ile Asp Leu Cys Ile Glu Val Leu Asn Arg Phe Glu Asn His Val Ile 
145                 150                 155                 160 
Asn Thr Ala Glu Glu Gly Val Ala Phe Val Arg Asp Val Gly Lys Asn 
                165                 170                 175     
Asn Val Lys Val Met Leu Asp Thr Phe His Met Asn Ile Glu Glu Asp 
            180                 185                 190         
Ser Phe Arg Ala Ala Ile Arg Thr Ala Gly Pro Leu Leu Gly His Phe 
        195                 200                 205             
His Thr Gly Glu Asn Asn Arg Arg Val Pro Gly Lys Gly Arg Leu Pro 
    210                 215                 220                 
Trp His Glu Ile Gly Ala Ala Leu Arg Glu Ile Asp Tyr Arg Gly Ala 
225                 230                 235                 240 
Val Val Met Glu Pro Phe Val Lys Ser Gly Gly Gly Ile Gly Arg Asp 
                245                 250                 255     
Ile Arg Val Trp Arg Asp Leu Ser Asn Gly Ala Asp Glu Ala Lys Met 
            260                 265                 270         
Asp Gln Asp Ala Arg Glu Ala Leu Ala Phe Ser Arg Tyr Val Leu Gly 
        275                 280                 285             
Gly Asp Lys Gly His His His His His His 
    290                 295             

<210>  4
<211>  894
<212>  DNA
<213>  Martelella sp.

<400>  4
atgaagttcg gtatctatta cagctattgg gaacaggaat ggagtgcaga ttgcctgcgt        60
catgttgaaa aagttgccaa actgggcttc gatgttattg aaattgccgc acatcatctg       120
aatagcttca gtccggcaca tattgatgat attgcccgtt gcgcacgtga taataatatt       180
gccgttacca gtggtctggg cccgagtcag gaacgtaatc tgagcagtcc ggatgcagat       240
attcgcaaag caggtcgcgc cttcttcgaa gaaaccttag tgaatattgc caaactggat       300
gttcatatta tcggtggtgc cctgcatagt tattggccgg ttgattatag ccagccggtg       360
gataaagaag gcgatcgcgc acgcggtgtt gaaggcatta gcagtctggc agacttcgca       420
gcagatctgg gtattgatct gtgcattgaa gttctgaatc gcttcgaaaa tcatgttatt       480
aataccgcag aagaaggcgt ggccttcgtt cgcgatgtgg gtaaaaataa tgtgaaagtg       540
atgctggata ccttccacat gaatattgaa gaagatagct tccgtgcagc cattcgtacc       600
gccggcccgc tgctgggtca cttccatacc ggtgaaaata atcgtcgcgt tccgggtaaa       660
ggccgtctgc cgtggcatga aattggtgcc gcactgcgcg aaattgatta tcgcggcgca       720
gttgttatgg aaccgttcgt taaaagcggc ggcggcattg gccgcgatat tcgtgtgtgg       780
cgcgatctga gtaatggtgc agatgaagcc aaaatggatc aggatgcccg tgaagccctg       840
gcattcagcc gctatgtgct gggtggcgat aaaggtcatc atcatcatca ccat             894

<210>  5
<211>  296
<212>  PRT
<213>  Novibacillus thermophilus

<400>  5
Met Lys Tyr Gly Val Tyr Phe Ala Tyr Trp Glu Ser Ser Trp Asn Val 
1               5                   10                  15      
Asn Phe Glu Lys Tyr Val Gln Lys Val Lys Glu Leu Gly Phe Asp Ile 
            20                  25                  30          
Leu Glu Val Ala Ala Leu Gly Leu Val Asn Leu Pro Asp Glu Lys Leu 
        35                  40                  45              
Glu Arg Leu Lys Gln Leu Ala Glu Gln His Asn Val Ile Leu Thr Ala 
    50                  55                  60                  
Gly Ile Gly Leu Pro Lys Glu Tyr Asp Val Ser Ser Ser Asp Ala Thr 
65                  70                  75                  80  
Val Arg Arg Asn Gly Ile Ala Phe Met Lys Lys Val Met Asp Ala Met 
                85                  90                  95      
Tyr Gln Ala Gly Ile Asp Arg Val Gly Gly Thr Val Tyr Ser Tyr Trp 
            100                 105                 110         
Pro Ala Asp Tyr Ser His Pro Phe Asp Lys Pro Thr Ala Arg Lys His 
        115                 120                 125             
Ser Ile Glu Ser Val Lys Glu Leu Ala Glu Tyr Ala Arg Gln Tyr Asp 
    130                 135                 140                 
Ile Thr Leu Leu Ile Glu Thr Leu Asn Arg Phe Glu Gln Phe Leu Leu 
145                 150                 155                 160 
Asn Asp Ala Glu Glu Ala Val Ser Tyr Val Lys Glu Val Asp Glu Pro 
                165                 170                 175     
Asn Val Lys Val Met Leu Asp Thr Phe His Met Asn Ile Glu Glu Asp 
            180                 185                 190         
Asn Ile Ala Asp Ala Ile Arg Tyr Thr Gly Asp His Leu Gly His Leu 
        195                 200                 205             
His Ile Gly Glu Ala Asn Arg Lys Val Pro Gly Lys Gly Ser Met Pro 
    210                 215                 220                 
Trp Lys Glu Ile Gly Gln Ala Leu Lys Asp Ile His Tyr Asp Gly Tyr 
225                 230                 235                 240 
Val Val Met Glu Pro Phe Val Lys Thr Gly Gly Gln Val Gly Gln Asp 
                245                 250                 255     
Ile Lys Val Trp Arg Asp Leu Ser Gly Asn Ala Thr Glu Glu Gln Leu 
            260                 265                 270         
Asp Arg Glu Leu Ala Glu Ser Leu Val Phe Val Lys Gln Ala Phe Gly 
        275                 280                 285             
Glu Leu His His His His His His 
    290                 295     

<210>  6
<211>  888
<212>  DNA
<213>  Novibacillus thermophilus

<400>  6
atgaagtacg gtgtgtactt cgcctattgg gaaagtagtt ggaatgttaa cttcgaaaaa        60
tacgtgcaga aagttaaaga actgggcttc gatattctgg aagtggcagc actgggtctg       120
gttaatctgc cggatgaaaa actggaacgc ctgaaacagc tggcagaaca gcataatgtt       180
attctgaccg caggtattgg cctgccgaaa gaatatgatg tgagtagtag tgatgccacc       240
gttcgccgca atggcattgc cttcatgaaa aaagtgatgg atgccatgta tcaggcaggc       300
attgatcgtg tgggtggtac cgtgtatagt tattggccgg ccgattatag tcatccgttc       360
gataaaccga ccgcacgcaa acatagtatt gaaagcgtta aagaattagc cgaatatgca       420
cgtcagtatg atattaccct gctgattgaa accttaaatc gcttcgaaca gttcctgctg       480
aatgatgcag aagaagcagt gagctatgtt aaagaagtgg atgaaccgaa tgtgaaagtg       540
atgctggata ccttccacat gaatattgaa gaagataata tcgccgatgc aattcgttat       600
accggtgatc atctgggtca tctgcatatt ggtgaagcca atcgtaaagt tccgggcaaa       660
ggcagcatgc cgtggaaaga aattggccag gcactgaaag atattcatta tgatggttat       720
gtggtgatgg aaccgttcgt taaaaccggc ggtcaggtgg gccaggatat taaagtgtgg       780
cgcgatctga gcggcaatgc caccgaagaa cagctggatc gcgaactggc agaaagcctg       840
gtgttcgtta aacaggcatt cggtgaactg catcatcatc atcaccat                    888

<210>  7
<211>  296
<212>  PRT
<213>  未知(Unknown)

<400>  7
Met Lys Tyr Gly Val Tyr Phe Ala Tyr Trp Glu Ser Ser Trp Asn Val 
1               5                   10                  15      
Asn Phe Glu Lys Tyr Val Gln Lys Val Lys Glu Leu Gly Phe Asp Ile 
            20                  25                  30          
Leu Glu Val Ala Ala Leu Gly Leu Val Asn Leu Pro Asp Glu Lys Leu 
        35                  40                  45              
Glu Arg Leu Lys Gln Leu Ala Glu Gln His Asn Val Ile Leu Thr Ala 
    50                  55                  60                  
Gly Ile Gly Leu Pro Lys Glu Tyr Asp Val Ser Ser Ser Asp Ala Thr 
65                  70                  75                  80  
Val Arg Arg Asn Gly Ile Ala Phe Met Lys Lys Val Met Asp Ala Met 
                85                  90                  95      
Tyr Gln Ala Gly Ile Asp Arg Val Asn Gly Thr Val Tyr Ser Tyr Trp 
            100                 105                 110         
Pro Ala Asp Tyr Ser His Pro Phe Asp Lys Pro Thr Ala Arg Lys His 
        115                 120                 125             
Ser Ile Glu Ser Val Lys Glu Leu Ala Glu Tyr Ala Arg Gln Tyr Asp 
    130                 135                 140                 
Ile Thr Lys Leu Ile Glu Thr Leu Asn Arg Phe Glu Gln Phe Leu Leu 
145                 150                 155                 160 
Asn Asp Ala Glu Glu Ala Val Ser Tyr Val Lys Glu Val Asp Glu Pro 
                165                 170                 175     
Asn Val Lys Val Met Leu Asp Tyr Phe His Met Asn Ile Glu Glu Asp 
            180                 185                 190         
Asn Ile Ala Asp Ala Ile Arg Tyr Thr Gly Asp His Leu Gly His Leu 
        195                 200                 205             
His Thr Gly Glu Ala Asn Arg Lys Val Pro Gly Lys Gly Ser Met Pro 
    210                 215                 220                 
Trp Lys Glu Ile Gly Gln Ala Leu Lys Asp Ile His Tyr Asp Gly Tyr 
225                 230                 235                 240 
Val Lys Met Glu Pro Phe Val Lys Thr Gly Gly Gln Val Gly Gln Asp 
                245                 250                 255     
Ile Lys Val Trp Arg Asp Leu Ser Gly Asn Ala Thr Glu Glu Gln Leu 
            260                 265                 270         
Asp Arg Glu Leu Ala Glu Ser Leu Val Phe Val Lys Gln Ala Phe Gly 
        275                 280                 285             
Glu Leu His His His His His His 
    290                 295     

