                         SEQUENCE LISTING

<110>  MOLECULAR TEMPLATES, INC.
       POMA, ERIC
       WALTZMAN, ROGER
       STRACK, THOMAS
 
<120>  USES OF CD20-BINDING MOLECULES AND ADDITIONAL THERAPEUTIC AGENTS

<130>  MTEM-012/01WO 333064-2112

<150>  US 63/061,062
<151>  2020-08-04

<150>  US 62/939,673
<151>  2019-11-24

<160>  391   

<170>  PatentIn version 3.5

<210>  1
<211>  293
<212>  PRT
<213>  Escherichia coli

<400>  1

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  2
<211>  293
<212>  PRT
<213>  Shigella dysenteriae

<400>  2

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  3
<211>  297
<212>  PRT
<213>  Escherichia coli

<400>  3

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Leu Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg Ser Val Ser Gln Lys Gln 
                245                 250                 255     


Lys Thr Glu Cys Gln Ile Val Gly Asp Arg Ala Ala Ile Lys Val Asn 
            260                 265                 270         


Asn Val Leu Trp Glu Ala Asn Thr Ile Ala Ala Leu Leu Asn Arg Lys 
        275                 280                 285             


Pro Gln Asp Leu Thr Glu Pro Asn Gln 
    290                 295         


<210>  4
<211>  251
<212>  PRT
<213>  Escherichia coli

<400>  4

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Gln Gln Trp Ile Ser Asn Pro Pro Thr 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Gly Tyr Thr Phe Thr Ser Tyr Asn Val His 
1               5                   10  


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
1               5                   10                  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Arg Ala Ser Ser Ser Val Ser Tyr Met Asp 
1               5                   10  


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Gln Gln Trp Ile Ser Asn Pro Pro Thr 
1               5                   


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10          


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Arg Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  21

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  23

Gly Phe Thr Phe Asn Asp Tyr Ala Met His 
1               5                   10  


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  24

Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  25

Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Gln Gln Arg Ser Asn Trp Pro Ile Thr 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  30

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  31

Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  33

Ala Pro Ser Asn Leu Ala Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  34

Gln Gln Trp Ser Phe Asn Pro Pro Thr 
1               5                   


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  35

Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn 
1               5                   10  


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  37

Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr 
1               5                   10  


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  38

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  39

Gln Met Ser Asn Leu Val Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  40

Ala Gln Asn Leu Glu Leu Pro Tyr Thr 
1               5                   


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  41

Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro 
1               5                   10                  15      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  42

Gly Gly Gly Gly Ser Gly Gly 
1               5           


<210>  43
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
1               5                   10                  15  


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Gly Gly Gly Gly Ser 
1               5   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  46

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  47
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (510)..(510)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
145                 150                 155                 160 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                165                 170                 175     


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            180                 185                 190         


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
225                 230                 235                 240 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr 
            260                 265                 270         


Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile 
        275                 280                 285             


Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr 
    290                 295                 300                 


Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val 
305                 310                 315                 320 


Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg 
                325                 330                 335     


Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg 
            340                 345                 350         


Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe 
        355                 360                 365             


Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr 
    370                 375                 380                 


Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg 
385                 390                 395                 400 


His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr 
                405                 410                 415     


Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val 
            420                 425                 430         


Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr 
        435                 440                 445             


Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp 
    450                 455                 460                 


Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp 
465                 470                 475                 480 


Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser 
                485                 490                 495     


Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His 
            500                 505                 510         


His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
        515                 520             


<210>  48
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (500)..(500)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Asp Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly 
                245                 250                 255     


Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val 
            260                 265                 270         


Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr 
        275                 280                 285             


Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly 
    290                 295                 300                 


Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly 
305                 310                 315                 320 


Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val 
                325                 330                 335     


Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp 
            340                 345                 350         


Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly 
        355                 360                 365             


Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr 
    370                 375                 380                 


Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu 
385                 390                 395                 400 


Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met 
                405                 410                 415     


Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile 
            420                 425                 430         


Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr 
        435                 440                 445             


Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu 
    450                 455                 460                 


Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly 
465                 470                 475                 480 


Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu 
                485                 490                 495     


Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 


<210>  49
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (490)..(490)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile 
        115                 120                 125             


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
    130                 135                 140                 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr 
                165                 170                 175     


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro 
225                 230                 235                 240 


Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser 
                245                 250                 255     


Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile 
            260                 265                 270         


Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met 
        275                 280                 285             


Ile Asp Ser Gly Thr Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly 
    290                 295                 300                 


Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu 
305                 310                 315                 320 


Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val 
                325                 330                 335     


Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr 
            340                 345                 350         


Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val 
        355                 360                 365             


Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr 
    370                 375                 380                 


Thr Ser Tyr Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln 
385                 390                 395                 400 


Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala 
                405                 410                 415     


Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp 
            420                 425                 430         


Leu Ser Gly Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr 
        435                 440                 445             


Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln 
    450                 455                 460                 


Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile 
465                 470                 475                 480 


Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg 
                485                 490                 495     


Val Ala Arg 
            


<210>  50
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
145                 150                 155                 160 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                165                 170                 175     


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            180                 185                 190         


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
225                 230                 235                 240 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510 


<210>  51
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (491)..(491)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Asp Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe 
                245                 250                 255     


Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala 
            260                 265                 270         


Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu 
        275                 280                 285             


Met Ile Asp Asn Leu Val Pro Met Val Ala Thr Val Val Asp Val Arg 
    290                 295                 300                 


Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val 
305                 310                 315                 320 


Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn 
                325                 330                 335     


Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr 
            340                 345                 350         


Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg 
        355                 360                 365             


Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu 
    370                 375                 380                 


Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr 
385                 390                 395                 400 


Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu 
                405                 410                 415     


Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp 
            420                 425                 430         


Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu 
        435                 440                 445             


Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly 
    450                 455                 460                 


Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala 
465                 470                 475                 480 


Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser 
                485                 490                 495     


Arg Val Ala Arg 
            500 


<210>  52
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (499)..(499)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile 
        115                 120                 125             


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
    130                 135                 140                 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr 
                165                 170                 175     


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro 
225                 230                 235                 240 


Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr 
                245                 250                 255     


Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
            260                 265                 270         


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
        275                 280                 285             


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
    290                 295                 300                 


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
305                 310                 315                 320 


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
                325                 330                 335     


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
            340                 345                 350         


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
        355                 360                 365             


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
    370                 375                 380                 


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
385                 390                 395                 400 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
                405                 410                 415     


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
            420                 425                 430         


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
        435                 440                 445             


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
    450                 455                 460                 


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
465                 470                 475                 480 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
                485                 490                 495     


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala 
            500                 505             


<210>  53
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  53

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            500                 505                 510         


His His His Ala Ser Arg Val Ala Arg 
        515                 520     


<210>  54
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  54

Met Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  55
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  55

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  56
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  56

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg 
            500     


<210>  57
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  57

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  58
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (493)..(493)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  58

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu 
                245                 250                 255     


Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg 
            260                 265                 270         


Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser 
        275                 280                 285             


Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp 
    290                 295                 300                 


Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu 
305                 310                 315                 320 


Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr 
                325                 330                 335     


Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro 
            340                 345                 350         


Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu 
        355                 360                 365             


Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His 
    370                 375                 380                 


Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser 
385                 390                 395                 400 


Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr 
                405                 410                 415     


Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr 
            420                 425                 430         


Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val 
        435                 440                 445             


Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr 
    450                 455                 460                 


His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile 
465                 470                 475                 480 


Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His 
                485                 490                 495     


Ala Ser Arg Val Ala Arg 
            500         


<210>  59
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (521)..(521)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  59

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile 
            260                 265                 270         


Leu Gly Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr 
        275                 280                 285             


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
    290                 295                 300                 


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
305                 310                 315                 320 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
                325                 330                 335     


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
            340                 345                 350         


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
        355                 360                 365             


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
    370                 375                 380                 


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
385                 390                 395                 400 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
                405                 410                 415     


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
            420                 425                 430         


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
        435                 440                 445             


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
    450                 455                 460                 


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
465                 470                 475                 480 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
                485                 490                 495     


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
            500                 505                 510         


Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val 
        515                 520                 525             


Ala Arg 
    530 


<210>  60
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (511)..(511)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  60

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys Glu Phe 
            260                 265                 270         


Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val 
        275                 280                 285             


Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly 
    290                 295                 300                 


Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala 
305                 310                 315                 320 


Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu 
                325                 330                 335     


Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn 
            340                 345                 350         


Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr 
        355                 360                 365             


Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr 
    370                 375                 380                 


Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn 
385                 390                 395                 400 


Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly 
                405                 410                 415     


Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr 
            420                 425                 430         


Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg 
        435                 440                 445             


Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu 
    450                 455                 460                 


Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro 
465                 470                 475                 480 


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
                485                 490                 495     


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His 
            500                 505                 510         


His His Ala Ser Arg Val Ala Arg 
        515                 520 


<210>  61
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  61

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val 
                245                 250                 255     


Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510 


<210>  62
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (483)..(483)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  62

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
                245                 250                 255     


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            260                 265                 270         


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp 
        275                 280                 285             


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    290                 295                 300                 


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
305                 310                 315                 320 


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                325                 330                 335     


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            340                 345                 350         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        355                 360                 365             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    370                 375                 380                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
385                 390                 395                 400 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                405                 410                 415     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            420                 425                 430         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        435                 440                 445             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    450                 455                 460                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
465                 470                 475                 480 


Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
                485                 490         


<210>  63
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  63

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            500                 505                 510         


His His His Ala Ser 
        515         


<210>  64
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  64

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu 
    290                 295                 300                 


Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  65
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (521)..(521)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  65

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile 
            260                 265                 270         


Leu Gly Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr 
        275                 280                 285             


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
    290                 295                 300                 


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
305                 310                 315                 320 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
                325                 330                 335     


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
            340                 345                 350         


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
        355                 360                 365             


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
    370                 375                 380                 


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
385                 390                 395                 400 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
                405                 410                 415     


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
            420                 425                 430         


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
        435                 440                 445             


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
    450                 455                 460                 


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
465                 470                 475                 480 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
                485                 490                 495     


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
            500                 505                 510         


Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser 
        515                 520                 525     


<210>  66
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  66

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            500                 505                 510         


His His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
        515                 520                 525 


<210>  67
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  67

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg Lys 
            500                 505                 510         


Asp Glu Leu 
        515 


<210>  68
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  68

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg Lys Asp Glu Leu 
            500                 505 


<210>  69
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  69

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


Lys Asp Glu Leu 
        515     


<210>  70
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (493)..(493)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  70

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu 
                245                 250                 255     


Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg 
            260                 265                 270         


Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser 
        275                 280                 285             


Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp 
    290                 295                 300                 


Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu 
305                 310                 315                 320 


Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr 
                325                 330                 335     


Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro 
            340                 345                 350         


Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu 
        355                 360                 365             


Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His 
    370                 375                 380                 


Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser 
385                 390                 395                 400 


Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr 
                405                 410                 415     


Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr 
            420                 425                 430         


Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val 
        435                 440                 445             


Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr 
    450                 455                 460                 


His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile 
465                 470                 475                 480 


Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His 
                485                 490                 495     


Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
            500                 505     


<210>  71
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (521)..(521)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  71

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile 
            260                 265                 270         


Leu Gly Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr 
        275                 280                 285             


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
    290                 295                 300                 


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
305                 310                 315                 320 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
                325                 330                 335     


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
            340                 345                 350         


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
        355                 360                 365             


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
    370                 375                 380                 


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
385                 390                 395                 400 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
                405                 410                 415     


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
            420                 425                 430         


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
        435                 440                 445             


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
    450                 455                 460                 


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
465                 470                 475                 480 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
                485                 490                 495     


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
            500                 505                 510         


Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val 
        515                 520                 525             


Ala Arg Lys Asp Glu Leu 
    530                 


<210>  72
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (511)..(511)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  72

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys Glu Phe 
            260                 265                 270         


Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val 
        275                 280                 285             


Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly 
    290                 295                 300                 


Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala 
305                 310                 315                 320 


Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu 
                325                 330                 335     


Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn 
            340                 345                 350         


Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr 
        355                 360                 365             


Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr 
    370                 375                 380                 


Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn 
385                 390                 395                 400 


Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly 
                405                 410                 415     


Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr 
            420                 425                 430         


Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg 
        435                 440                 445             


Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu 
    450                 455                 460                 


Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro 
465                 470                 475                 480 


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
                485                 490                 495     


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His 
            500                 505                 510         


His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
        515                 520                 


<210>  73
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  73

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val 
                245                 250                 255     


Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  74
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (483)..(483)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  74

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
                245                 250                 255     


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            260                 265                 270         


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp 
        275                 280                 285             


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    290                 295                 300                 


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
305                 310                 315                 320 


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                325                 330                 335     


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            340                 345                 350         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        355                 360                 365             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    370                 375                 380                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
385                 390                 395                 400 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                405                 410                 415     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            420                 425                 430         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        435                 440                 445             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    450                 455                 460                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
465                 470                 475                 480 


Leu Asn Cys His His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
                485                 490                 495     


<210>  75
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  75

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            500                 505                 510         


His His His Ala Ser Lys Asp Glu Leu 
        515                 520     


<210>  76
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  76

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu 
    290                 295                 300                 


Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg Lys 
            500                 505                 510         


Asp Glu Leu 
        515 


<210>  77
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (521)..(521)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  77

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile 
            260                 265                 270         


Leu Gly Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr 
        275                 280                 285             


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
    290                 295                 300                 


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
305                 310                 315                 320 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
                325                 330                 335     


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
            340                 345                 350         


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
        355                 360                 365             


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
    370                 375                 380                 


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
385                 390                 395                 400 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
                405                 410                 415     


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
            420                 425                 430         


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
        435                 440                 445             


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
    450                 455                 460                 


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
465                 470                 475                 480 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
                485                 490                 495     


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
            500                 505                 510         


Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Lys Asp 
        515                 520                 525             


Glu Leu 
    530 


<210>  78
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  78

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  79
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (484)..(484)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  79

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro 
    130                 135                 140                 


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
145                 150                 155                 160 


Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
                165                 170                 175     


Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala 
        195                 200                 205             


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val 
                245                 250                 255     


Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr 
            260                 265                 270         


Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly 
        275                 280                 285             


Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly 
    290                 295                 300                 


Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val 
305                 310                 315                 320 


Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp 
                325                 330                 335     


Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly 
            340                 345                 350         


Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr 
        355                 360                 365             


Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu 
    370                 375                 380                 


Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met 
385                 390                 395                 400 


Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile 
                405                 410                 415     


Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr 
            420                 425                 430         


Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu 
        435                 440                 445             


Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly 
    450                 455                 460                 


Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu 
465                 470                 475                 480 


Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg Lys Asp Glu 
                485                 490                 495     


Leu 
    


<210>  80
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (513)..(513)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  80

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu 
145                 150                 155                 160 


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
                165                 170                 175     


Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro 
            180                 185                 190         


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
    210                 215                 220                 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr 
225                 230                 235                 240 


Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu 
                245                 250                 255     


Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys 
            260                 265                 270         


Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu 
        275                 280                 285             


Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser 
    290                 295                 300                 


Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn Leu 
305                 310                 315                 320 


Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn 
                325                 330                 335     


Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe 
            340                 345                 350         


Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His 
        355                 360                 365             


Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser 
    370                 375                 380                 


Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln 
385                 390                 395                 400 


Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His 
                405                 410                 415     


Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe 
            420                 425                 430         


Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly 
        435                 440                 445             


Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr 
    450                 455                 460                 


Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val 
465                 470                 475                 480 


Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser 
                485                 490                 495     


Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn 
            500                 505                 510         


Cys His His His Ala Ser Arg Val Ala Arg 
        515                 520         


<210>  81
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (493)..(493)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  81

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro 
    130                 135                 140                 


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
145                 150                 155                 160 


Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
                165                 170                 175     


Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala 
        195                 200                 205             


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro 
225                 230                 235                 240 


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu 
                245                 250                 255     


Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg 
            260                 265                 270         


Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser 
        275                 280                 285             


Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp 
    290                 295                 300                 


Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu 
305                 310                 315                 320 


Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr 
                325                 330                 335     


Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro 
            340                 345                 350         


Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu 
        355                 360                 365             


Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His 
    370                 375                 380                 


Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Ala Thr Ser 
385                 390                 395                 400 


Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr 
                405                 410                 415     


Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr 
            420                 425                 430         


Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr Ala Glu Asp Val 
        435                 440                 445             


Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr 
    450                 455                 460                 


His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile 
465                 470                 475                 480 


Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His 
                485                 490                 495     


Ala Ser Arg Val Ala Arg 
            500         


<210>  82
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  82

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn 
    290                 295                 300                 


Leu Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  83
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  83

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            500                 505                 510         


His His His Ala Ser Ala Val Ala Ala 
        515                 520     


<210>  84
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  84

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


Lys Asp Glu Leu 
        515     


<210>  85
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (504)..(504)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  85

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu 
145                 150                 155                 160 


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
                165                 170                 175     


Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro 
            180                 185                 190         


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
    210                 215                 220                 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr 
225                 230                 235                 240 


Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala 
            260                 265                 270         


Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr 
        275                 280                 285             


Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp 
    290                 295                 300                 


Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp 
305                 310                 315                 320 


Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn 
                325                 330                 335     


Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr 
            340                 345                 350         


Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val 
        355                 360                 365             


Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly 
    370                 375                 380                 


Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser 
385                 390                 395                 400 


Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val 
                405                 410                 415     


Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg 
            420                 425                 430         


Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser 
        435                 440                 445             


Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn 
    450                 455                 460                 


Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser 
465                 470                 475                 480 


Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly 
                485                 490                 495     


Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala 
            500                 505                 510         


Arg 
    


<210>  86
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (484)..(484)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  86

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro 
    130                 135                 140                 


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
145                 150                 155                 160 


Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
                165                 170                 175     


Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala 
        195                 200                 205             


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val 
                245                 250                 255     


Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr 
            260                 265                 270         


Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly 
        275                 280                 285             


Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly 
    290                 295                 300                 


Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val 
305                 310                 315                 320 


Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp 
                325                 330                 335     


Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly 
            340                 345                 350         


Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr 
        355                 360                 365             


Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu 
    370                 375                 380                 


Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met 
385                 390                 395                 400 


Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile 
                405                 410                 415     


Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr 
            420                 425                 430         


Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu 
        435                 440                 445             


Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly 
    450                 455                 460                 


Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu 
465                 470                 475                 480 


Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
                485                 490             


<210>  87
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  87

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser 
            500                 505             


<210>  88
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  88

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn 
    290                 295                 300                 


Leu Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  89
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  89

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            500                 505                 510         


His His His Ala Ser Lys Asp Glu Leu 
        515                 520     


<210>  90
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  90

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn 
                165                 170                 175     


Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr 
    210                 215                 220                 


Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  91
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  91

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
        115                 120                 125             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
    130                 135                 140                 


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
145                 150                 155                 160 


Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
                165                 170                 175     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
            180                 185                 190         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
        195                 200                 205             


Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg 
            500     


<210>  92
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn 
                165                 170                 175     


Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr 
    210                 215                 220                 


Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Thr Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  93
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  93

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn 
                165                 170                 175     


Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr 
    210                 215                 220                 


Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  94
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  94

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn 
    290                 295                 300                 


Leu Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  95
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  95

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            500                 505                 510         


His His His Ala Ser Ala Val Ala Ala 
        515                 520     


<210>  96
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  96

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys 
145                 150                 155                 160 


Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
                165                 170                 175     


Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr 
    210                 215                 220                 


Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly 
                245                 250                 255     


Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  97
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  97

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val 
    130                 135                 140                 


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
            180                 185                 190         


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
        195                 200                 205             


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
    210                 215                 220                 


Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr 
225                 230                 235                 240 


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  98
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (502)..(502)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  98

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val 
    130                 135                 140                 


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
            180                 185                 190         


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
        195                 200                 205             


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
    210                 215                 220                 


Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr 
225                 230                 235                 240 


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Thr Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  99
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  99

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys 
145                 150                 155                 160 


Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
                165                 170                 175     


Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr 
    210                 215                 220                 


Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala 
                485                 490                 495     


Ser 
    


<210>  100
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (482)..(482)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  100

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
        115                 120                 125             


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
    130                 135                 140                 


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
145                 150                 155                 160 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
                165                 170                 175     


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
            180                 185                 190         


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
        195                 200                 205             


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
    210                 215                 220                 


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
                245                 250                 255     


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            260                 265                 270         


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        275                 280                 285             


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    290                 295                 300                 


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
305                 310                 315                 320 


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                325                 330                 335     


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            340                 345                 350         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        355                 360                 365             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    370                 375                 380                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
385                 390                 395                 400 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                405                 410                 415     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            420                 425                 430         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        435                 440                 445             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    450                 455                 460                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
465                 470                 475                 480 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                485                 490     


<210>  101
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  101

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys 
145                 150                 155                 160 


Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
                165                 170                 175     


Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr 
    210                 215                 220                 


Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly 
                245                 250                 255     


Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Cys His His His Ala Ser 
            500                 505     


<210>  102
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  102

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly 
                245                 250                 255     


Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510 


<210>  103
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  103

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg 
            500     


<210>  104
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  104

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Thr Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg 
            500     


<210>  105
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (482)..(482)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  105

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser Gln Ile 
        115                 120                 125             


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
    130                 135                 140                 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro 
                165                 170                 175     


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
                245                 250                 255     


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            260                 265                 270         


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        275                 280                 285             


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    290                 295                 300                 


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
305                 310                 315                 320 


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                325                 330                 335     


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            340                 345                 350         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        355                 360                 365             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    370                 375                 380                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
385                 390                 395                 400 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                405                 410                 415     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            420                 425                 430         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        435                 440                 445             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    450                 455                 460                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
465                 470                 475                 480 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                485                 490     


<210>  106
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (511)..(511)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  106

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
145                 150                 155                 160 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                165                 170                 175     


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            180                 185                 190         


Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro 
225                 230                 235                 240 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Glu Phe Pro 
                245                 250                 255     


Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe 
            260                 265                 270         


Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val 
        275                 280                 285             


Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly 
    290                 295                 300                 


Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val Ala Thr Val 
305                 310                 315                 320 


Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu 
                325                 330                 335     


Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn 
            340                 345                 350         


Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr 
        355                 360                 365             


Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr 
    370                 375                 380                 


Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn 
385                 390                 395                 400 


Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly 
                405                 410                 415     


Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr 
            420                 425                 430         


Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg 
        435                 440                 445             


Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu 
    450                 455                 460                 


Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro 
465                 470                 475                 480 


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
                485                 490                 495     


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His 
            500                 505                 510         


His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
        515                 520                 


<210>  107
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (482)..(482)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  107

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser Gln Ile 
        115                 120                 125             


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
    130                 135                 140                 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro 
                165                 170                 175     


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
                245                 250                 255     


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            260                 265                 270         


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        275                 280                 285             


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    290                 295                 300                 


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
305                 310                 315                 320 


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                325                 330                 335     


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            340                 345                 350         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        355                 360                 365             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    370                 375                 380                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
385                 390                 395                 400 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                405                 410                 415     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            420                 425                 430         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        435                 440                 445             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    450                 455                 460                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
465                 470                 475                 480 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                485                 490     


<210>  108
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (504)..(504)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Glu Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn 
            180                 185                 190         


Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala 
            260                 265                 270         


Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr 
        275                 280                 285             


Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp 
    290                 295                 300                 


Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp 
305                 310                 315                 320 


Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn 
                325                 330                 335     


Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr 
            340                 345                 350         


Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val 
        355                 360                 365             


Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly 
    370                 375                 380                 


Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser 
385                 390                 395                 400 


Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val 
                405                 410                 415     


Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg 
            420                 425                 430         


Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser 
        435                 440                 445             


Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn 
    450                 455                 460                 


Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser 
465                 470                 475                 480 


Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly 
                485                 490                 495     


Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala 
            500                 505                 510         


Arg 
    


<210>  109
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (513)..(513)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Glu Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn 
            180                 185                 190         


Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys 
            260                 265                 270         


Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu 
        275                 280                 285             


Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser 
    290                 295                 300                 


Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu 
305                 310                 315                 320 


Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn 
                325                 330                 335     


Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe 
            340                 345                 350         


Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His 
        355                 360                 365             


Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser 
    370                 375                 380                 


Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln 
385                 390                 395                 400 


Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His 
                405                 410                 415     


Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe 
            420                 425                 430         


Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly 
        435                 440                 445             


Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr 
    450                 455                 460                 


Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val 
465                 470                 475                 480 


Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser 
                485                 490                 495     


Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn 
            500                 505                 510         


Cys His His His Ala Ser Arg Val Ala Arg 
        515                 520         


<210>  110
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  110

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
        115                 120                 125             


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
    130                 135                 140                 


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr 
145                 150                 155                 160 


Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
                165                 170                 175     


Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        195                 200                 205             


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro 
    210                 215                 220                 


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly 
                245                 250                 255     


Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Thr Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  111
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
        115                 120                 125             


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
    130                 135                 140                 


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr 
145                 150                 155                 160 


Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
                165                 170                 175     


Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        195                 200                 205             


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro 
    210                 215                 220                 


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly 
                245                 250                 255     


Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser 
            500                 505             


<210>  112
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (494)..(494)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  112

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
        115                 120                 125             


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
    130                 135                 140                 


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr 
145                 150                 155                 160 


Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
                165                 170                 175     


Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        195                 200                 205             


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro 
    210                 215                 220                 


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr 
                245                 250                 255     


Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile 
            260                 265                 270         


Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr 
        275                 280                 285             


Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val Ala Thr Val Val 
    290                 295                 300                 


Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg 
305                 310                 315                 320 


Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg 
                325                 330                 335     


Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe 
            340                 345                 350         


Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr 
        355                 360                 365             


Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg 
    370                 375                 380                 


His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr 
385                 390                 395                 400 


Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val 
                405                 410                 415     


Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr 
            420                 425                 430         


Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp 
        435                 440                 445             


Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp 
    450                 455                 460                 


Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser 
465                 470                 475                 480 


Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His 
                485                 490                 495     


His Ala Ser Arg Val Ala Arg 
            500             


<210>  113
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (495)..(495)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  113

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Glu Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn 
            180                 185                 190         


Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe 
                245                 250                 255     


Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val 
            260                 265                 270         


Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly 
        275                 280                 285             


Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala 
    290                 295                 300                 


Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu 
305                 310                 315                 320 


Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn 
                325                 330                 335     


Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr 
            340                 345                 350         


Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr 
        355                 360                 365             


Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn 
    370                 375                 380                 


Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly 
385                 390                 395                 400 


Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr 
                405                 410                 415     


Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg 
            420                 425                 430         


Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu 
        435                 440                 445             


Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro 
    450                 455                 460                 


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
465                 470                 475                 480 


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His 
                485                 490                 495     


His His Ala Ser 
            500 


<210>  114
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (504)..(504)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  114

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp 
145                 150                 155                 160 


Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala 
            260                 265                 270         


Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr 
        275                 280                 285             


Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp 
    290                 295                 300                 


Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp 
305                 310                 315                 320 


Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn 
                325                 330                 335     


Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr 
            340                 345                 350         


Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val 
        355                 360                 365             


Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly 
    370                 375                 380                 


Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser 
385                 390                 395                 400 


Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val 
                405                 410                 415     


Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg 
            420                 425                 430         


Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser 
        435                 440                 445             


Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn 
    450                 455                 460                 


Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser 
465                 470                 475                 480 


Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly 
                485                 490                 495     


Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala 
            500                 505                 510         


Arg 
    


<210>  115
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (503)..(503)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  115

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
        115                 120                 125             


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
    130                 135                 140                 


Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln 
145                 150                 155                 160 


Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp 
                165                 170                 175     


Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser 
            180                 185                 190         


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly 
                245                 250                 255     


Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


Lys Asp Glu Leu 
        515     


<210>  116
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (513)..(513)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  116

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp 
145                 150                 155                 160 


Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys 
            260                 265                 270         


Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu 
        275                 280                 285             


Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser 
    290                 295                 300                 


Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn Leu 
305                 310                 315                 320 


Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn 
                325                 330                 335     


Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe 
            340                 345                 350         


Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His 
        355                 360                 365             


Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser 
    370                 375                 380                 


Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln 
385                 390                 395                 400 


Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His 
                405                 410                 415     


Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe 
            420                 425                 430         


Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly 
        435                 440                 445             


Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr 
    450                 455                 460                 


Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val 
465                 470                 475                 480 


Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser 
                485                 490                 495     


Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn 
            500                 505                 510         


Cys His His His Ala Ser Arg Val Ala Arg 
        515                 520         


<210>  117
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (513)..(513)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  117

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp 
145                 150                 155                 160 


Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys 
            260                 265                 270         


Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu 
        275                 280                 285             


Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser 
    290                 295                 300                 


Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu 
305                 310                 315                 320 


Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn 
                325                 330                 335     


Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe 
            340                 345                 350         


Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His 
        355                 360                 365             


Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser 
    370                 375                 380                 


Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln 
385                 390                 395                 400 


Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His 
                405                 410                 415     


Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe 
            420                 425                 430         


Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly 
        435                 440                 445             


Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr 
    450                 455                 460                 


Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val 
465                 470                 475                 480 


Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser 
                485                 490                 495     


Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn 
            500                 505                 510         


Cys His His His Ala Ser Arg Val Ala Arg 
        515                 520         


<210>  118
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (494)..(494)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  118

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
        115                 120                 125             


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
    130                 135                 140                 


Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln 
145                 150                 155                 160 


Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp 
                165                 170                 175     


Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser 
            180                 185                 190         


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr 
                245                 250                 255     


Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile 
            260                 265                 270         


Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr 
        275                 280                 285             


Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val Ala Thr Val Val 
    290                 295                 300                 


Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg 
305                 310                 315                 320 


Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg 
                325                 330                 335     


Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe 
            340                 345                 350         


Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr 
        355                 360                 365             


Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg 
    370                 375                 380                 


His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr 
385                 390                 395                 400 


Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val 
                405                 410                 415     


Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr 
            420                 425                 430         


Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp 
        435                 440                 445             


Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp 
    450                 455                 460                 


Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser 
465                 470                 475                 480 


Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His 
                485                 490                 495     


His Ala Ser Arg Val Ala Arg 
            500             


<210>  119
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (505)..(505)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  119

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
    130                 135                 140                 


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
145                 150                 155                 160 


Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln 
                165                 170                 175     


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp 
            180                 185                 190         


Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr 
        195                 200                 205             


Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
    210                 215                 220                 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly 
225                 230                 235                 240 


Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr 
            260                 265                 270         


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
        275                 280                 285             


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
    290                 295                 300                 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
305                 310                 315                 320 


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
                325                 330                 335     


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
            340                 345                 350         


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
        355                 360                 365             


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
    370                 375                 380                 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
385                 390                 395                 400 


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
                405                 410                 415     


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
            420                 425                 430         


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
        435                 440                 445             


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
    450                 455                 460                 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
465                 470                 475                 480 


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
                485                 490                 495     


Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Ala Val 
            500                 505                 510         


Ala Ala 
        


<210>  120
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  120

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ala Tyr Leu Gln 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr 
        355                 360                 365             


Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
    370                 375                 380                 


Val Thr Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val 
                405                 410                 415     


Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val 
            420                 425                 430         


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser 
    450                 455                 460                 


Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala 
            500                 505                 510         


Gly Thr Lys Leu Glu Leu Lys Ser 
        515                 520 


<210>  121
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  121

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ala Tyr Leu Gln 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr 
        355                 360                 365             


Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
    370                 375                 380                 


Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
385                 390                 395                 400 


Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala 
                405                 410                 415     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
            420                 425                 430         


Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
        435                 440                 445             


Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val 
465                 470                 475                 480 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn 
                485                 490                 495     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser 
            500                 505                 510 


<210>  122
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  122

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ala Tyr Leu Gln 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr 
        355                 360                 365             


Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
    370                 375                 380                 


Val Thr Val Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser 
385                 390                 395                 400 


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                405                 410                 415     


Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210>  123
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  123

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp 
        355                 360                 365             


Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
                405                 410                 415     


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
            420                 425                 430         


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
        435                 440                 445             


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
    450                 455                 460                 


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
465                 470                 475                 480 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
                485                 490                 495     


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser 
            500                 505                 510     


<210>  124
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  124

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp 
        355                 360                 365             


Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
385                 390                 395                 400 


Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
                405                 410                 415     


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
                485                 490                 495     


Leu Glu Leu Lys Ser 
            500     


<210>  125
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  125

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                405                 410                 415     


Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu 
            420                 425                 430         


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        515                 520     


<210>  126
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  126

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510     


<210>  127
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  127

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
385                 390                 395                 400 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                405                 410                 415     


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys 
            500     


<210>  128
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  128

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile 
                405                 410                 415     


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


<210>  129
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  129

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr 
    370                 375                 380                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu 
385                 390                 395                 400 


Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
                405                 410                 415     


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
        435                 440                 445             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly 
                485                 490                 495     


Thr Lys Leu Glu Leu Lys 
            500         


<210>  130
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  130

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser 
385                 390                 395                 400 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                405                 410                 415     


Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            420                 425                 430         


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    450                 455                 460                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
465                 470                 475                 480 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                485                 490         


<210>  131
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  131

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln Gln Pro Gly Ala 
            260                 265                 270         


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser 
        275                 280                 285             


Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro 
    290                 295                 300                 


Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
                325                 330                 335     


Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            340                 345                 350         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser 
        355                 360                 365             


Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
                405                 410                 415     


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
            420                 425                 430         


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
    450                 455                 460                 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
465                 470                 475                 480 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
                485                 490                 495     


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
            500                 505                 510         


Lys Leu Glu Leu Lys 
        515         


<210>  132
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  132

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510     


<210>  133
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  133

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                405                 410                 415     


Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu 
            420                 425                 430         


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Glu Leu 
        515                 520                 


<210>  134
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  134

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  135
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  135

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
385                 390                 395                 400 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                405                 410                 415     


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys Asp Glu Leu 
            500                 


<210>  136
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  136

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile 
                405                 410                 415     


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


Asp Glu Leu 
        515 


<210>  137
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  137

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr 
    370                 375                 380                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu 
385                 390                 395                 400 


Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
                405                 410                 415     


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
        435                 440                 445             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly 
                485                 490                 495     


Thr Lys Leu Glu Leu Lys Asp Glu Leu 
            500                 505 


<210>  138
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  138

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser 
385                 390                 395                 400 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                405                 410                 415     


Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            420                 425                 430         


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    450                 455                 460                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
465                 470                 475                 480 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Glu Leu 
                485                 490                 495 


<210>  139
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  139

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln Gln Pro Gly Ala 
            260                 265                 270         


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser 
        275                 280                 285             


Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro 
    290                 295                 300                 


Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
                325                 330                 335     


Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            340                 345                 350         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser 
        355                 360                 365             


Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
                405                 410                 415     


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
            420                 425                 430         


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
    450                 455                 460                 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
465                 470                 475                 480 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
                485                 490                 495     


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
            500                 505                 510         


Lys Leu Glu Leu Lys Asp Glu Leu 
        515                 520 


<210>  140
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  140

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  141
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  141

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
305                 310                 315                 320 


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
        355                 360                 365             


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
385                 390                 395                 400 


Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His 
            420                 425                 430         


Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln 
        435                 440                 445             


Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val 
    450                 455                 460                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
465                 470                 475                 480 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln 
                485                 490                 495     


Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            500                 505                 510         


Lys 
    


<210>  142
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  142

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        275                 280                 285             


Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly 
305                 310                 315                 320 


Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile 
    370                 375                 380                 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
385                 390                 395                 400 


Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly 
                405                 410                 415     


Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
            420                 425                 430         


Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg 
        435                 440                 445             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
    450                 455                 460                 


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu 
465                 470                 475                 480 


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                485                 490                 


<210>  143
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  143

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
305                 310                 315                 320 


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
        355                 360                 365             


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
                405                 410                 415     


Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile 
            420                 425                 430         


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
        435                 440                 445             


Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
    450                 455                 460                 


Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                485                 490                 495     


Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr 
            500                 505                 510         


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        515                 520             


<210>  144
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  144

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
305                 310                 315                 320 


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
        355                 360                 365             


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu 
385                 390                 395                 400 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
                405                 410                 415     


Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
            420                 425                 430         


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser 
        435                 440                 445             


Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    450                 455                 460                 


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
465                 470                 475                 480 


Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly 
                485                 490                 495     


Gly Thr Lys Val Glu Ile Lys 
            500             


<210>  145
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  145

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
305                 310                 315                 320 


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
        355                 360                 365             


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
385                 390                 395                 400 


Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His 
            420                 425                 430         


Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln 
        435                 440                 445             


Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val 
    450                 455                 460                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
465                 470                 475                 480 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln 
                485                 490                 495     


Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            500                 505                 510         


Lys 
    


<210>  146
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  146

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr 
            260                 265                 270         


Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile 
        275                 280                 285             


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
    290                 295                 300                 


Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
305                 310                 315                 320 


Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
            340                 345                 350         


Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr 
        355                 360                 365             


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Val Gln Leu Val Gln 
385                 390                 395                 400 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
                405                 410                 415     


Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg 
            420                 425                 430         


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly 
        435                 440                 445             


Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile 
    450                 455                 460                 


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
465                 470                 475                 480 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp 
                485                 490                 495     


Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ser 
    


<210>  147
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  147

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
            260                 265                 270         


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu 
        275                 280                 285             


His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly 
305                 310                 315                 320 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala 
            340                 345                 350         


Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
        355                 360                 365             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
385                 390                 395                 400 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
                405                 410                 415     


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
            420                 425                 430         


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
        435                 440                 445             


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
    450                 455                 460                 


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
465                 470                 475                 480 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
                485                 490                 495     


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            500                 505                 510         


Ser Ser 
        


<210>  148
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  148

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
            260                 265                 270         


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu 
        275                 280                 285             


His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly 
305                 310                 315                 320 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala 
            340                 345                 350         


Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
        355                 360                 365             


Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
    370                 375                 380                 


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
385                 390                 395                 400 


Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro 
                405                 410                 415     


Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp 
            420                 425                 430         


Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp 
        435                 440                 445             


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
    450                 455                 460                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp 
465                 470                 475                 480 


Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490                 


<210>  149
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  149

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr Gln Thr Pro Leu 
            260                 265                 270         


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        275                 280                 285             


Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
    290                 295                 300                 


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser 
305                 310                 315                 320 


Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            340                 345                 350         


Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
385                 390                 395                 400 


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                405                 410                 415     


Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr 
        435                 440                 445             


Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
    450                 455                 460                 


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu 
                485                 490                 495     


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 


<210>  150
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  150

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr 
            260                 265                 270         


Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile 
        275                 280                 285             


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
    290                 295                 300                 


Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
305                 310                 315                 320 


Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
            340                 345                 350         


Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr 
        355                 360                 365             


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Val Gln Leu Val Gln 
385                 390                 395                 400 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
                405                 410                 415     


Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg 
            420                 425                 430         


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly 
        435                 440                 445             


Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile 
    450                 455                 460                 


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
465                 470                 475                 480 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp 
                485                 490                 495     


Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ser 
    


<210>  151
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  151

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr Gln Thr Pro Leu 
            260                 265                 270         


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        275                 280                 285             


Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
    290                 295                 300                 


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser 
305                 310                 315                 320 


Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            340                 345                 350         


Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
385                 390                 395                 400 


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                405                 410                 415     


Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr 
        435                 440                 445             


Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
    450                 455                 460                 


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu 
                485                 490                 495     


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 


<210>  152
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  152

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu 
385                 390                 395                 400 


Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln 
            420                 425                 430         


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
        435                 440                 445             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
465                 470                 475                 480 


Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp 
                485                 490                 495     


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510 


<210>  153
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  153

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser Gln Ala Tyr Leu Gln 
    370                 375                 380                 


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
                405                 410                 415     


Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
            420                 425                 430         


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
    450                 455                 460                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr 
465                 470                 475                 480 


Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
                485                 490                 495     


Val Thr Val Ser 
            500 


<210>  154
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  154

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu 
385                 390                 395                 400 


Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln 
            420                 425                 430         


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
        435                 440                 445             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
465                 470                 475                 480 


Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp 
                485                 490                 495     


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510 


<210>  155
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  155

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu 
385                 390                 395                 400 


Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln 
            420                 425                 430         


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
        435                 440                 445             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
465                 470                 475                 480 


Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp 
                485                 490                 495     


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510 


<210>  156
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  156

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
            260                 265                 270         


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
        275                 280                 285             


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
    290                 295                 300                 


Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
305                 310                 315                 320 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
                325                 330                 335     


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro 
            340                 345                 350         


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu 
385                 390                 395                 400 


Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
                405                 410                 415     


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg 
            420                 425                 430         


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
        435                 440                 445             


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
465                 470                 475                 480 


Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr 
                485                 490                 495     


Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510     


<210>  157
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  157

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu 
385                 390                 395                 400 


Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln 
            420                 425                 430         


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
        435                 440                 445             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
465                 470                 475                 480 


Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp 
                485                 490                 495     


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510 


<210>  158
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  158

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
        275                 280                 285             


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
305                 310                 315                 320 


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly 
        435                 440                 445             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    450                 455                 460                 


Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
465                 470                 475                 480 


Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr 
                485                 490                 495     


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505                 510     


<210>  159
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  159

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        275                 280                 285             


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    290                 295                 300                 


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp 
            340                 345                 350         


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile 
        435                 440                 445             


Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr 
                485                 490                 495     


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505                 510         


<210>  160
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  160

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        275                 280                 285             


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    290                 295                 300                 


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp 
            340                 345                 350         


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile 
        435                 440                 445             


Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr 
                485                 490                 495     


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505                 510         


<210>  161
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  161

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile 
                245                 250                 255     


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
            260                 265                 270         


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
        275                 280                 285             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp 
    290                 295                 300                 


Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
                325                 330                 335     


Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe 
            340                 345                 350         


Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly 
        355                 360                 365             


Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    370                 375                 380                 


Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
385                 390                 395                 400 


Ser Gly Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly 
            420                 425                 430         


Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        435                 440                 445             


Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    450                 455                 460                 


Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn 
465                 470                 475                 480 


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210>  162
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  162

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        275                 280                 285             


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    290                 295                 300                 


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp 
            340                 345                 350         


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
        355                 360                 365             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    370                 375                 380                 


Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
385                 390                 395                 400 


Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                405                 410                 415     


Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp 
            420                 425                 430         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser 
        435                 440                 445             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr 
    450                 455                 460                 


Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp 
465                 470                 475                 480 


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                485                 490         


<210>  163
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  163

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Glu Ile Val Leu Thr Gln Ser Pro Ala 
            260                 265                 270         


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        275                 280                 285             


Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly 
305                 310                 315                 320 


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
            340                 345                 350         


Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu 
        355                 360                 365             


Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    370                 375                 380                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
385                 390                 395                 400 


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp 
                405                 410                 415     


Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            420                 425                 430         


Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser 
        435                 440                 445             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu 
    450                 455                 460                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr 
465                 470                 475                 480 


Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val 
                485                 490                 495     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505         


<210>  164
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  164

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
        355                 360                 365             


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
385                 390                 395                 400 


Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
                405                 410                 415     


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            500                 505                 510         


<210>  165
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  165

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val 
385                 390                 395                 400 


Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val 
                405                 410                 415     


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe 
            420                 425                 430         


Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser 
        435                 440                 445             


Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly 
    450                 455                 460                 


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
465                 470                 475                 480 


Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly 
                485                 490                 495     


Gly Thr Lys Leu Glu Ile Lys 
            500             


<210>  166
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  166

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val 
385                 390                 395                 400 


Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val 
                405                 410                 415     


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe 
            420                 425                 430         


Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser 
        435                 440                 445             


Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly 
    450                 455                 460                 


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
465                 470                 475                 480 


Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly 
                485                 490                 495     


Gly Thr Lys Leu Glu Ile Lys 
            500             


<210>  167
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  167

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    370                 375                 380                 


Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala 
385                 390                 395                 400 


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
                405                 410                 415     


Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
            420                 425                 430         


Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
        435                 440                 445             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val 
    450                 455                 460                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn 
465                 470                 475                 480 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                485                 490             


<210>  168
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  168

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
        355                 360                 365             


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Lys Gly 
                405                 410                 415     


Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
            420                 425                 430         


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
        435                 440                 445             


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
    450                 455                 460                 


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
                485                 490                 495     


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
            500                 505                 510         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Asp Glu Leu 
        515                 520                 525 


<210>  169
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  169

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    370                 375                 380                 


Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala 
385                 390                 395                 400 


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
                405                 410                 415     


Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
            420                 425                 430         


Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
        435                 440                 445             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val 
    450                 455                 460                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn 
465                 470                 475                 480 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                485                 490             


<210>  170
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  170

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ala Gln Leu 
        355                 360                 365             


Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
385                 390                 395                 400 


Glu Gly Ser Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala 
                405                 410                 415     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
            420                 425                 430         


Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
        435                 440                 445             


Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val 
465                 470                 475                 480 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn 
                485                 490                 495     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 


<210>  171
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  171

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ala Gln Leu 
        355                 360                 365             


Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Ser Gln Ser 
385                 390                 395                 400 


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                405                 410                 415     


Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu 
                485                 490                 495     


Glu Leu Lys 
            


<210>  172
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  172

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Gly Gly Gly Gly Ser Gly Gly Gln Val 
                245                 250                 255     


Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
            260                 265                 270         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
        275                 280                 285             


His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala 
    290                 295                 300                 


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
305                 310                 315                 320 


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
                325                 330                 335     


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            340                 345                 350         


Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Asp Ile Val Leu Ser Gln Ser Pro Ala Ile 
385                 390                 395                 400 


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
                405                 410                 415     


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
            420                 425                 430         


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    450                 455                 460                 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
465                 470                 475                 480 


Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                485                 490                 495     


<210>  173
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  173

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
        355                 360                 365             


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
385                 390                 395                 400 


Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
                405                 410                 415     


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            500                 505                 510         


<210>  174
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  174

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
        355                 360                 365             


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ala Gly Gly Gly Gly Ser Thr Lys Gly Gln Ile Val Leu 
385                 390                 395                 400 


Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
                405                 410                 415     


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln 
            420                 425                 430         


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
        435                 440                 445             


Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Glu Ile Lys 
            500         


<210>  175
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Cys residue at this position is available to form a homodimer or 
       heterodimer via a disulfide bond with any of SEQ ID NOS 47-175

<400>  175

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala 
                405                 410                 415     


Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala 
            420                 425                 430         


Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser 
        435                 440                 445             


Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val 
    450                 455                 460                 


Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
465                 470                 475                 480 


Ile Ser Arg Val Glu Ala Glu Asp 
                485             


<210>  176
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  176

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
145                 150                 155                 160 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                165                 170                 175     


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            180                 185                 190         


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
225                 230                 235                 240 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr 
            260                 265                 270         


Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile 
        275                 280                 285             


Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr 
    290                 295                 300                 


Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val 
305                 310                 315                 320 


Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg 
                325                 330                 335     


Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg 
            340                 345                 350         


Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe 
        355                 360                 365             


Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr 
    370                 375                 380                 


Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg 
385                 390                 395                 400 


His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr 
                405                 410                 415     


Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val 
            420                 425                 430         


Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr 
        435                 440                 445             


Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp 
    450                 455                 460                 


Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp 
465                 470                 475                 480 


Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser 
                485                 490                 495     


Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His 
            500                 505                 510         


His Ala Ser Arg Val Ala Arg 
        515                 


<210>  177
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  177

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Asp Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly 
                245                 250                 255     


Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val 
            260                 265                 270         


Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr 
        275                 280                 285             


Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly 
    290                 295                 300                 


Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly 
305                 310                 315                 320 


Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val 
                325                 330                 335     


Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp 
            340                 345                 350         


Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly 
        355                 360                 365             


Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr 
    370                 375                 380                 


Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu 
385                 390                 395                 400 


Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met 
                405                 410                 415     


Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile 
            420                 425                 430         


Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr 
        435                 440                 445             


Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu 
    450                 455                 460                 


Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly 
465                 470                 475                 480 


Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu 
                485                 490                 495     


Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 


<210>  178
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  178

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile 
        115                 120                 125             


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
    130                 135                 140                 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr 
                165                 170                 175     


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro 
225                 230                 235                 240 


Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser 
                245                 250                 255     


Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile 
            260                 265                 270         


Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met 
        275                 280                 285             


Ile Asp Ser Gly Thr Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly 
    290                 295                 300                 


Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu 
305                 310                 315                 320 


Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val 
                325                 330                 335     


Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr 
            340                 345                 350         


Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val 
        355                 360                 365             


Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr 
    370                 375                 380                 


Thr Ser Tyr Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln 
385                 390                 395                 400 


Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala 
                405                 410                 415     


Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp 
            420                 425                 430         


Leu Ser Gly Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr 
        435                 440                 445             


Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln 
    450                 455                 460                 


Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile 
465                 470                 475                 480 


Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg 
                485                 490                 495     


Val Ala Arg 
            


<210>  179
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  179

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
145                 150                 155                 160 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                165                 170                 175     


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            180                 185                 190         


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
225                 230                 235                 240 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  180
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  180

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Asp Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe 
                245                 250                 255     


Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala 
            260                 265                 270         


Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu 
        275                 280                 285             


Met Ile Asp Asn Leu Val Pro Met Val Ala Thr Val Val Asp Val Arg 
    290                 295                 300                 


Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val 
305                 310                 315                 320 


Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn 
                325                 330                 335     


Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr 
            340                 345                 350         


Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg 
        355                 360                 365             


Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu 
    370                 375                 380                 


Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr 
385                 390                 395                 400 


Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu 
                405                 410                 415     


Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp 
            420                 425                 430         


Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu 
        435                 440                 445             


Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly 
    450                 455                 460                 


Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala 
465                 470                 475                 480 


Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser 
                485                 490                 495     


Arg Val Ala Arg 
            500 


<210>  181
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  181

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile 
        115                 120                 125             


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
    130                 135                 140                 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr 
                165                 170                 175     


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro 
225                 230                 235                 240 


Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr 
                245                 250                 255     


Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
            260                 265                 270         


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
        275                 280                 285             


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
    290                 295                 300                 


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
305                 310                 315                 320 


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
                325                 330                 335     


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
            340                 345                 350         


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
        355                 360                 365             


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
    370                 375                 380                 


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
385                 390                 395                 400 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
                405                 410                 415     


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
            420                 425                 430         


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
        435                 440                 445             


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
    450                 455                 460                 


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
465                 470                 475                 480 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
                485                 490                 495     


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala 
            500                 505             


<210>  182
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  182

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser 
            500                 505                 510         


His His His Ala Ser Arg Val Ala Arg 
        515                 520     


<210>  183
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  183

Met Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  184
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  184

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  185
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  185

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg 
            500     


<210>  186
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  186

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  187
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  187

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu 
                245                 250                 255     


Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg 
            260                 265                 270         


Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser 
        275                 280                 285             


Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp 
    290                 295                 300                 


Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu 
305                 310                 315                 320 


Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr 
                325                 330                 335     


Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro 
            340                 345                 350         


Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu 
        355                 360                 365             


Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His 
    370                 375                 380                 


Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser 
385                 390                 395                 400 


Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr 
                405                 410                 415     


Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr 
            420                 425                 430         


Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val 
        435                 440                 445             


Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr 
    450                 455                 460                 


His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile 
465                 470                 475                 480 


Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His 
                485                 490                 495     


Ala Ser Arg Val Ala Arg 
            500         


<210>  188
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  188

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile 
            260                 265                 270         


Leu Gly Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr 
        275                 280                 285             


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
    290                 295                 300                 


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
305                 310                 315                 320 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
                325                 330                 335     


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
            340                 345                 350         


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
        355                 360                 365             


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
    370                 375                 380                 


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
385                 390                 395                 400 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
                405                 410                 415     


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
            420                 425                 430         


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
        435                 440                 445             


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
    450                 455                 460                 


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
465                 470                 475                 480 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
                485                 490                 495     


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
            500                 505                 510         


Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val 
        515                 520                 525             


Ala Arg 
    530 


<210>  189
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  189

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys Glu Phe 
            260                 265                 270         


Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val 
        275                 280                 285             


Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly 
    290                 295                 300                 


Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala 
305                 310                 315                 320 


Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu 
                325                 330                 335     


Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn 
            340                 345                 350         


Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr 
        355                 360                 365             


Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr 
    370                 375                 380                 


Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn 
385                 390                 395                 400 


Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly 
                405                 410                 415     


Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr 
            420                 425                 430         


Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg 
        435                 440                 445             


Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu 
    450                 455                 460                 


Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro 
465                 470                 475                 480 


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
                485                 490                 495     


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His 
            500                 505                 510         


His His Ala Ser Arg Val Ala Arg 
        515                 520 


<210>  190
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  190

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val 
                245                 250                 255     


Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510 


<210>  191
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  191

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
                245                 250                 255     


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            260                 265                 270         


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp 
        275                 280                 285             


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    290                 295                 300                 


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
305                 310                 315                 320 


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                325                 330                 335     


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            340                 345                 350         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        355                 360                 365             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    370                 375                 380                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
385                 390                 395                 400 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                405                 410                 415     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            420                 425                 430         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        435                 440                 445             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    450                 455                 460                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
465                 470                 475                 480 


Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
                485                 490         


<210>  192
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  192

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser 
            500                 505                 510         


His His His Ala Ser 
        515         


<210>  193
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  193

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu 
    290                 295                 300                 


Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  194
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  194

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile 
            260                 265                 270         


Leu Gly Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr 
        275                 280                 285             


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
    290                 295                 300                 


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
305                 310                 315                 320 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
                325                 330                 335     


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
            340                 345                 350         


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
        355                 360                 365             


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
    370                 375                 380                 


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
385                 390                 395                 400 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
                405                 410                 415     


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
            420                 425                 430         


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
        435                 440                 445             


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
    450                 455                 460                 


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
465                 470                 475                 480 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
                485                 490                 495     


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
            500                 505                 510         


Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser 
        515                 520                 525     


<210>  195
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  195

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser 
            500                 505                 510         


His His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
        515                 520                 525 


<210>  196
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  196

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg Lys 
            500                 505                 510         


Asp Glu Leu 
        515 


<210>  197
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  197

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg Lys Asp Glu Leu 
            500                 505 


<210>  198
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  198

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


Lys Asp Glu Leu 
        515     


<210>  199
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  199

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu 
                245                 250                 255     


Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg 
            260                 265                 270         


Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser 
        275                 280                 285             


Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp 
    290                 295                 300                 


Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu 
305                 310                 315                 320 


Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr 
                325                 330                 335     


Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro 
            340                 345                 350         


Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu 
        355                 360                 365             


Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His 
    370                 375                 380                 


Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser 
385                 390                 395                 400 


Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr 
                405                 410                 415     


Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr 
            420                 425                 430         


Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val 
        435                 440                 445             


Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr 
    450                 455                 460                 


His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile 
465                 470                 475                 480 


Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His 
                485                 490                 495     


Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
            500                 505     


<210>  200
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  200

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile 
            260                 265                 270         


Leu Gly Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr 
        275                 280                 285             


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
    290                 295                 300                 


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
305                 310                 315                 320 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
                325                 330                 335     


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
            340                 345                 350         


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
        355                 360                 365             


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
    370                 375                 380                 


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
385                 390                 395                 400 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
                405                 410                 415     


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
            420                 425                 430         


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
        435                 440                 445             


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
    450                 455                 460                 


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
465                 470                 475                 480 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
                485                 490                 495     


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
            500                 505                 510         


Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val 
        515                 520                 525             


Ala Arg Lys Asp Glu Leu 
    530                 


<210>  201
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  201

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys Glu Phe 
            260                 265                 270         


Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val 
        275                 280                 285             


Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly 
    290                 295                 300                 


Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala 
305                 310                 315                 320 


Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu 
                325                 330                 335     


Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn 
            340                 345                 350         


Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr 
        355                 360                 365             


Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr 
    370                 375                 380                 


Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn 
385                 390                 395                 400 


Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly 
                405                 410                 415     


Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr 
            420                 425                 430         


Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg 
        435                 440                 445             


Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu 
    450                 455                 460                 


Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro 
465                 470                 475                 480 


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
                485                 490                 495     


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His 
            500                 505                 510         


His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
        515                 520                 


<210>  202
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  202

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val 
                245                 250                 255     


Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  203
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  203

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
                165                 170                 175     


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
    210                 215                 220                 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
                245                 250                 255     


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            260                 265                 270         


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp 
        275                 280                 285             


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    290                 295                 300                 


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
305                 310                 315                 320 


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                325                 330                 335     


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            340                 345                 350         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        355                 360                 365             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    370                 375                 380                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
385                 390                 395                 400 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                405                 410                 415     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            420                 425                 430         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        435                 440                 445             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    450                 455                 460                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
465                 470                 475                 480 


Leu Asn Ser His His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
                485                 490                 495     


<210>  204
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  204

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser 
            500                 505                 510         


His His His Ala Ser Lys Asp Glu Leu 
        515                 520     


<210>  205
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  205

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu 
    290                 295                 300                 


Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg Lys 
            500                 505                 510         


Asp Glu Leu 
        515 


<210>  206
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  206

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser 
145                 150                 155                 160 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
            180                 185                 190         


Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
    210                 215                 220                 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser 
225                 230                 235                 240 


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile 
            260                 265                 270         


Leu Gly Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr 
        275                 280                 285             


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
    290                 295                 300                 


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
305                 310                 315                 320 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
                325                 330                 335     


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
            340                 345                 350         


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
        355                 360                 365             


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
    370                 375                 380                 


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
385                 390                 395                 400 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
                405                 410                 415     


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
            420                 425                 430         


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
        435                 440                 445             


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
    450                 455                 460                 


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
465                 470                 475                 480 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
                485                 490                 495     


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
            500                 505                 510         


Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Lys Asp 
        515                 520                 525             


Glu Leu 
    530 


<210>  207
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  207

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  208
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  208

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro 
    130                 135                 140                 


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
145                 150                 155                 160 


Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
                165                 170                 175     


Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala 
        195                 200                 205             


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val 
                245                 250                 255     


Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr 
            260                 265                 270         


Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly 
        275                 280                 285             


Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly 
    290                 295                 300                 


Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val 
305                 310                 315                 320 


Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp 
                325                 330                 335     


Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly 
            340                 345                 350         


Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr 
        355                 360                 365             


Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu 
    370                 375                 380                 


Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met 
385                 390                 395                 400 


Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile 
                405                 410                 415     


Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr 
            420                 425                 430         


Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu 
        435                 440                 445             


Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly 
    450                 455                 460                 


Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu 
465                 470                 475                 480 


Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
                485                 490             


<210>  209
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  209

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu 
145                 150                 155                 160 


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
                165                 170                 175     


Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro 
            180                 185                 190         


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
    210                 215                 220                 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr 
225                 230                 235                 240 


Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu 
                245                 250                 255     


Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys 
            260                 265                 270         


Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu 
        275                 280                 285             


Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser 
    290                 295                 300                 


Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn Leu 
305                 310                 315                 320 


Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn 
                325                 330                 335     


Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe 
            340                 345                 350         


Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His 
        355                 360                 365             


Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser 
    370                 375                 380                 


Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln 
385                 390                 395                 400 


Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His 
                405                 410                 415     


Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe 
            420                 425                 430         


Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly 
        435                 440                 445             


Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr 
    450                 455                 460                 


Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val 
465                 470                 475                 480 


Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser 
                485                 490                 495     


Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn 
            500                 505                 510         


Ser His His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
        515                 520                 525     


<210>  210
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  210

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro 
    130                 135                 140                 


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
145                 150                 155                 160 


Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
                165                 170                 175     


Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala 
        195                 200                 205             


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro 
225                 230                 235                 240 


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu 
                245                 250                 255     


Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg 
            260                 265                 270         


Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser 
        275                 280                 285             


Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp 
    290                 295                 300                 


Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu 
305                 310                 315                 320 


Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr 
                325                 330                 335     


Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro 
            340                 345                 350         


Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu 
        355                 360                 365             


Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His 
    370                 375                 380                 


Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Ala Thr Ser 
385                 390                 395                 400 


Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr 
                405                 410                 415     


Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr 
            420                 425                 430         


Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr Ala Glu Asp Val 
        435                 440                 445             


Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr 
    450                 455                 460                 


His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile 
465                 470                 475                 480 


Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His 
                485                 490                 495     


Ala Ser Arg Val Ala Arg 
            500         


<210>  211
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  211

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn 
    290                 295                 300                 


Leu Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  212
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  212

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser 
            500                 505                 510         


His His His Ala Ser Ala Val Ala Ala 
        515                 520     


<210>  213
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  213

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  214
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  214

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu 
145                 150                 155                 160 


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
                165                 170                 175     


Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro 
            180                 185                 190         


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
    210                 215                 220                 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr 
225                 230                 235                 240 


Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala 
            260                 265                 270         


Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr 
        275                 280                 285             


Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp 
    290                 295                 300                 


Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp 
305                 310                 315                 320 


Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn 
                325                 330                 335     


Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr 
            340                 345                 350         


Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val 
        355                 360                 365             


Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly 
    370                 375                 380                 


Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser 
385                 390                 395                 400 


Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val 
                405                 410                 415     


Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg 
            420                 425                 430         


Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser 
        435                 440                 445             


Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn 
    450                 455                 460                 


Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser 
465                 470                 475                 480 


Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly 
                485                 490                 495     


Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala 
            500                 505                 510         


Arg 
    


<210>  215
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  215

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro 
    130                 135                 140                 


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
145                 150                 155                 160 


Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
                165                 170                 175     


Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
            180                 185                 190         


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala 
        195                 200                 205             


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro 
    210                 215                 220                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val 
                245                 250                 255     


Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr 
            260                 265                 270         


Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly 
        275                 280                 285             


Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly 
    290                 295                 300                 


Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val 
305                 310                 315                 320 


Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp 
                325                 330                 335     


Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly 
            340                 345                 350         


Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr 
        355                 360                 365             


Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu 
    370                 375                 380                 


Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met 
385                 390                 395                 400 


Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile 
                405                 410                 415     


Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr 
            420                 425                 430         


Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu 
        435                 440                 445             


Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly 
    450                 455                 460                 


Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu 
465                 470                 475                 480 


Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
                485                 490             


<210>  216
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  216

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser 
            500                 505             


<210>  217
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  217

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn 
    290                 295                 300                 


Leu Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  218
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  218

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser 
            500                 505                 510         


His His His Ala Ser 
        515         


<210>  219
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  219

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn 
                165                 170                 175     


Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr 
    210                 215                 220                 


Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  220
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  220

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
        115                 120                 125             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
    130                 135                 140                 


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
145                 150                 155                 160 


Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
                165                 170                 175     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
            180                 185                 190         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
        195                 200                 205             


Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Phe Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg 
            500     


<210>  221
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  221

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn 
                165                 170                 175     


Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr 
    210                 215                 220                 


Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Thr Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  222
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  222

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn 
                165                 170                 175     


Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr 
    210                 215                 220                 


Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  223
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  223

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn 
    290                 295                 300                 


Leu Val Pro Met Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  224
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  224

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Phe 
                245                 250                 255     


Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu 
            260                 265                 270         


Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn 
        275                 280                 285             


Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe 
305                 310                 315                 320 


Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
                325                 330                 335     


Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val 
            340                 345                 350         


Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val 
        355                 360                 365             


Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr 
    370                 375                 380                 


Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile 
385                 390                 395                 400 


Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser 
                405                 410                 415     


Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val 
            420                 425                 430         


Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe 
        435                 440                 445             


Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala 
    450                 455                 460                 


Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu 
465                 470                 475                 480 


Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
                485                 490                 495     


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser 
            500                 505                 510         


His His His Ala Ser Ala Val Ala Ala 
        515                 520     


<210>  225
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  225

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys 
145                 150                 155                 160 


Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
                165                 170                 175     


Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr 
    210                 215                 220                 


Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly 
                245                 250                 255     


Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  226
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  226

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val 
    130                 135                 140                 


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
            180                 185                 190         


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
        195                 200                 205             


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
    210                 215                 220                 


Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr 
225                 230                 235                 240 


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  227
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  227

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val 
    130                 135                 140                 


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
            180                 185                 190         


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
        195                 200                 205             


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
    210                 215                 220                 


Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr 
225                 230                 235                 240 


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Thr Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu 
305                 310                 315                 320 


Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210>  228
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  228

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys 
145                 150                 155                 160 


Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
                165                 170                 175     


Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr 
    210                 215                 220                 


Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala 
                485                 490                 495     


Ser 
    


<210>  229
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  229

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
        115                 120                 125             


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
    130                 135                 140                 


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
145                 150                 155                 160 


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
                165                 170                 175     


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
            180                 185                 190         


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
        195                 200                 205             


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
    210                 215                 220                 


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
                245                 250                 255     


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            260                 265                 270         


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        275                 280                 285             


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    290                 295                 300                 


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
305                 310                 315                 320 


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                325                 330                 335     


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            340                 345                 350         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        355                 360                 365             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    370                 375                 380                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
385                 390                 395                 400 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                405                 410                 415     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            420                 425                 430         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        435                 440                 445             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    450                 455                 460                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
465                 470                 475                 480 


Asn Ser His His His Ala Ser Arg Val Ala Arg 
                485                 490     


<210>  230
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  230

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys 
145                 150                 155                 160 


Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly 
                165                 170                 175     


Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr 
    210                 215                 220                 


Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly 
                245                 250                 255     


Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Ser His His His Ala Ser 
            500                 505     


<210>  231
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  231

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly 
                245                 250                 255     


Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr 
            260                 265                 270         


Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln 
        275                 280                 285             


Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser 
    290                 295                 300                 


Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu 
305                 310                 315                 320 


Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr 
                325                 330                 335     


Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala 
            340                 345                 350         


Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser 
        355                 360                 365             


Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg 
    370                 375                 380                 


Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp 
385                 390                 395                 400 


Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala 
                405                 410                 415     


Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln 
            420                 425                 430         


Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser 
        435                 440                 445             


Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg 
    450                 455                 460                 


Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
465                 470                 475                 480 


Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala 
                485                 490                 495     


Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510 


<210>  232
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  232

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg 
            500     


<210>  233
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  233

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly 
        115                 120                 125             


Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp 
                245                 250                 255     


Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser 
            260                 265                 270         


Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu 
        275                 280                 285             


Leu Met Ile Asp Ser Gly Thr Gly Asp Asn Leu Phe Ala Val Asp Val 
    290                 295                 300                 


Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile 
305                 310                 315                 320 


Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn 
                325                 330                 335     


Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly 
            340                 345                 350         


Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln 
        355                 360                 365             


Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser 
    370                 375                 380                 


Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu 
385                 390                 395                 400 


Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala 
                405                 410                 415     


Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu 
            420                 425                 430         


Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp 
        435                 440                 445             


Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His 
    450                 455                 460                 


Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn 
465                 470                 475                 480 


Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala 
                485                 490                 495     


Ser Arg Val Ala Arg 
            500     


<210>  234
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  234

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser Gln Ile 
        115                 120                 125             


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
    130                 135                 140                 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro 
                165                 170                 175     


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
                245                 250                 255     


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            260                 265                 270         


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        275                 280                 285             


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    290                 295                 300                 


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
305                 310                 315                 320 


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                325                 330                 335     


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            340                 345                 350         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        355                 360                 365             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    370                 375                 380                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
385                 390                 395                 400 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                405                 410                 415     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            420                 425                 430         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        435                 440                 445             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    450                 455                 460                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
465                 470                 475                 480 


Asn Ser His His His Ala Ser Arg Val Ala Arg 
                485                 490     


<210>  235
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  235

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
145                 150                 155                 160 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                165                 170                 175     


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            180                 185                 190         


Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    210                 215                 220                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro 
225                 230                 235                 240 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Glu Phe Pro 
                245                 250                 255     


Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe 
            260                 265                 270         


Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val 
        275                 280                 285             


Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly 
    290                 295                 300                 


Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val Ala Thr Val 
305                 310                 315                 320 


Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu 
                325                 330                 335     


Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn 
            340                 345                 350         


Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr 
        355                 360                 365             


Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr 
    370                 375                 380                 


Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn 
385                 390                 395                 400 


Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly 
                405                 410                 415     


Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr 
            420                 425                 430         


Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg 
        435                 440                 445             


Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu 
    450                 455                 460                 


Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro 
465                 470                 475                 480 


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
                485                 490                 495     


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His 
            500                 505                 510         


His His Ala Ser Arg Val Ala Arg Lys Asp Glu Leu 
        515                 520                 


<210>  236
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  236

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser Gln Ile 
        115                 120                 125             


Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys 
    130                 135                 140                 


Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro 
                165                 170                 175     


Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly 
    210                 215                 220                 


Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
                245                 250                 255     


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            260                 265                 270         


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        275                 280                 285             


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    290                 295                 300                 


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
305                 310                 315                 320 


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                325                 330                 335     


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            340                 345                 350         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        355                 360                 365             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    370                 375                 380                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
385                 390                 395                 400 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                405                 410                 415     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            420                 425                 430         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        435                 440                 445             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    450                 455                 460                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
465                 470                 475                 480 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                485                 490     


<210>  237
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  237

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Glu Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn 
            180                 185                 190         


Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala 
            260                 265                 270         


Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr 
        275                 280                 285             


Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp 
    290                 295                 300                 


Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp 
305                 310                 315                 320 


Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn 
                325                 330                 335     


Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr 
            340                 345                 350         


Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val 
        355                 360                 365             


Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly 
    370                 375                 380                 


Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser 
385                 390                 395                 400 


Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val 
                405                 410                 415     


Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg 
            420                 425                 430         


Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser 
        435                 440                 445             


Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn 
    450                 455                 460                 


Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser 
465                 470                 475                 480 


Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly 
                485                 490                 495     


Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala 
            500                 505                 510         


Arg 
    


<210>  238
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  238

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Glu Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn 
            180                 185                 190         


Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys 
            260                 265                 270         


Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu 
        275                 280                 285             


Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser 
    290                 295                 300                 


Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu 
305                 310                 315                 320 


Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn 
                325                 330                 335     


Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe 
            340                 345                 350         


Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His 
        355                 360                 365             


Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser 
    370                 375                 380                 


Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln 
385                 390                 395                 400 


Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His 
                405                 410                 415     


Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe 
            420                 425                 430         


Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly 
        435                 440                 445             


Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr 
    450                 455                 460                 


Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val 
465                 470                 475                 480 


Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser 
                485                 490                 495     


Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn 
            500                 505                 510         


Ser His His His Ala Ser Arg Val Ala Arg 
        515                 520         


<210>  239
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  239

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
        115                 120                 125             


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
    130                 135                 140                 


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr 
145                 150                 155                 160 


Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
                165                 170                 175     


Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        195                 200                 205             


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro 
    210                 215                 220                 


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly 
                245                 250                 255     


Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Thr Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210>  240
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  240

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
        115                 120                 125             


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
    130                 135                 140                 


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr 
145                 150                 155                 160 


Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
                165                 170                 175     


Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        195                 200                 205             


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro 
    210                 215                 220                 


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly 
                245                 250                 255     


Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser 
            500                 505             


<210>  241
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  241

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
        115                 120                 125             


Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser 
    130                 135                 140                 


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr 
145                 150                 155                 160 


Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu 
                165                 170                 175     


Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        195                 200                 205             


Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro 
    210                 215                 220                 


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr 
                245                 250                 255     


Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile 
            260                 265                 270         


Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr 
        275                 280                 285             


Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val Ala Thr Val Val 
    290                 295                 300                 


Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg 
305                 310                 315                 320 


Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg 
                325                 330                 335     


Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe 
            340                 345                 350         


Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr 
        355                 360                 365             


Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg 
    370                 375                 380                 


His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr 
385                 390                 395                 400 


Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val 
                405                 410                 415     


Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr 
            420                 425                 430         


Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp 
        435                 440                 445             


Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp 
    450                 455                 460                 


Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser 
465                 470                 475                 480 


Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His 
                485                 490                 495     


His Ala Ser Arg Val Ala Arg 
            500             


<210>  242
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  242

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Glu Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn 
            180                 185                 190         


Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe 
                245                 250                 255     


Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val 
            260                 265                 270         


Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly 
        275                 280                 285             


Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala 
    290                 295                 300                 


Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu 
305                 310                 315                 320 


Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn 
                325                 330                 335     


Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr 
            340                 345                 350         


Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr 
        355                 360                 365             


Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn 
    370                 375                 380                 


Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly 
385                 390                 395                 400 


Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr 
                405                 410                 415     


Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg 
            420                 425                 430         


Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu 
        435                 440                 445             


Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro 
    450                 455                 460                 


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
465                 470                 475                 480 


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His 
                485                 490                 495     


His His Ala Ser 
            500 


<210>  243
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  243

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp 
145                 150                 155                 160 


Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala 
            260                 265                 270         


Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr 
        275                 280                 285             


Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp 
    290                 295                 300                 


Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp 
305                 310                 315                 320 


Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn 
                325                 330                 335     


Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr 
            340                 345                 350         


Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val 
        355                 360                 365             


Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly 
    370                 375                 380                 


Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser 
385                 390                 395                 400 


Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val 
                405                 410                 415     


Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg 
            420                 425                 430         


Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser 
        435                 440                 445             


Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn 
    450                 455                 460                 


Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser 
465                 470                 475                 480 


Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly 
                485                 490                 495     


Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala 
            500                 505                 510         


Arg 
    


<210>  244
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  244

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
        115                 120                 125             


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
    130                 135                 140                 


Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln 
145                 150                 155                 160 


Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp 
                165                 170                 175     


Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser 
            180                 185                 190         


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly 
                245                 250                 255     


Phe Val Phe Thr Leu Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


Lys Asp Glu Leu 
        515     


<210>  245
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  245

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp 
145                 150                 155                 160 


Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys 
            260                 265                 270         


Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu 
        275                 280                 285             


Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser 
    290                 295                 300                 


Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn Leu 
305                 310                 315                 320 


Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn 
                325                 330                 335     


Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe 
            340                 345                 350         


Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His 
        355                 360                 365             


Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser 
    370                 375                 380                 


Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln 
385                 390                 395                 400 


Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His 
                405                 410                 415     


Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe 
            420                 425                 430         


Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly 
        435                 440                 445             


Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr 
    450                 455                 460                 


Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val 
465                 470                 475                 480 


Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser 
                485                 490                 495     


Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn 
            500                 505                 510         


Ser His His His Ala Ser Arg Val Ala Arg 
        515                 520         


<210>  246
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  246

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp 
145                 150                 155                 160 


Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
                245                 250                 255     


Ser Ser Gly Gly Ala Pro Gly Ile Leu Gly Phe Val Phe Thr Leu Lys 
            260                 265                 270         


Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu 
        275                 280                 285             


Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser 
    290                 295                 300                 


Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn Leu 
305                 310                 315                 320 


Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe Asn 
                325                 330                 335     


Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe 
            340                 345                 350         


Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His 
        355                 360                 365             


Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser Ser 
    370                 375                 380                 


Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln 
385                 390                 395                 400 


Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His 
                405                 410                 415     


Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe 
            420                 425                 430         


Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly 
        435                 440                 445             


Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met Thr 
    450                 455                 460                 


Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val 
465                 470                 475                 480 


Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser 
                485                 490                 495     


Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn 
            500                 505                 510         


Ser His His His Ala Ser Arg Val Ala Arg 
        515                 520         


<210>  247
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  247

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
        115                 120                 125             


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
    130                 135                 140                 


Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln 
145                 150                 155                 160 


Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp 
                165                 170                 175     


Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser 
            180                 185                 190         


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Phe Pro Lys 
225                 230                 235                 240 


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Lys Glu Phe Thr 
                245                 250                 255     


Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile 
            260                 265                 270         


Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr 
        275                 280                 285             


Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val Ala Thr Val Val 
    290                 295                 300                 


Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg 
305                 310                 315                 320 


Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg 
                325                 330                 335     


Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe 
            340                 345                 350         


Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr 
        355                 360                 365             


Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg 
    370                 375                 380                 


His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr 
385                 390                 395                 400 


Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg Phe Val Thr Val 
                405                 410                 415     


Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr 
            420                 425                 430         


Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp 
        435                 440                 445             


Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp 
    450                 455                 460                 


Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser 
465                 470                 475                 480 


Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Ser His His 
                485                 490                 495     


His Ala Ser Arg Val Ala Arg 
            500             


<210>  248
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  248

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
    130                 135                 140                 


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
145                 150                 155                 160 


Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln 
                165                 170                 175     


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp 
            180                 185                 190         


Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr 
        195                 200                 205             


Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
    210                 215                 220                 


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly 
225                 230                 235                 240 


Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Lys Glu Phe Thr Leu Asp Phe Ser Thr 
            260                 265                 270         


Ala Lys Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly 
        275                 280                 285             


Thr Pro Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile 
    290                 295                 300                 


Asp Ser Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile 
305                 310                 315                 320 


Asp Pro Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg 
                325                 330                 335     


Asn Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe 
            340                 345                 350         


Tyr Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala 
        355                 360                 365             


Val Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala 
    370                 375                 380                 


Gly Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr 
385                 390                 395                 400 


Ser Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser 
                405                 410                 415     


Val Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu 
            420                 425                 430         


Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu 
        435                 440                 445             


Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu 
    450                 455                 460                 


Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp 
465                 470                 475                 480 


Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu 
                485                 490                 495     


Gly Ser Val Ala Leu Ile Leu Asn Ser His His His Ala Ser Ala Val 
            500                 505                 510         


Ala Ala 
        


<210>  249
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  249

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ala Tyr Leu Gln 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr 
        355                 360                 365             


Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
    370                 375                 380                 


Val Thr Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val 
                405                 410                 415     


Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val 
            420                 425                 430         


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser 
    450                 455                 460                 


Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala 
            500                 505                 510         


Gly Thr Lys Leu Glu Leu Lys Ser 
        515                 520 


<210>  250
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  250

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ala Tyr Leu Gln 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr 
        355                 360                 365             


Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
    370                 375                 380                 


Val Thr Val Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
385                 390                 395                 400 


Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala 
                405                 410                 415     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
            420                 425                 430         


Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
        435                 440                 445             


Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val 
465                 470                 475                 480 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn 
                485                 490                 495     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser 
            500                 505                 510 


<210>  251
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  251

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ala Tyr Leu Gln 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr 
        355                 360                 365             


Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
    370                 375                 380                 


Val Thr Val Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser 
385                 390                 395                 400 


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                405                 410                 415     


Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu 
                485                 490                 495     


Glu Leu Lys Ser 
            500 


<210>  252
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  252

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp 
        355                 360                 365             


Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser 
                405                 410                 415     


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
            420                 425                 430         


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys 
        435                 440                 445             


Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
    450                 455                 460                 


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg 
465                 470                 475                 480 


Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe 
                485                 490                 495     


Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser 
            500                 505                 510     


<210>  253
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  253

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp 
        355                 360                 365             


Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
385                 390                 395                 400 


Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
                405                 410                 415     


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
                485                 490                 495     


Leu Glu Leu Lys Ser 
            500     


<210>  254
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  254

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                405                 410                 415     


Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu 
            420                 425                 430         


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        515                 520     


<210>  255
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  255

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510     


<210>  256
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  256

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
385                 390                 395                 400 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                405                 410                 415     


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys 
            500     


<210>  257
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  257

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile 
                405                 410                 415     


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


<210>  258
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  258

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr 
    370                 375                 380                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu 
385                 390                 395                 400 


Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
                405                 410                 415     


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
        435                 440                 445             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly 
                485                 490                 495     


Thr Lys Leu Glu Leu Lys 
            500         


<210>  259
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  259

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser 
385                 390                 395                 400 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                405                 410                 415     


Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            420                 425                 430         


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    450                 455                 460                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
465                 470                 475                 480 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                485                 490         


<210>  260
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  260

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln Gln Pro Gly Ala 
            260                 265                 270         


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser 
        275                 280                 285             


Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro 
    290                 295                 300                 


Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
                325                 330                 335     


Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            340                 345                 350         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser 
        355                 360                 365             


Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
                405                 410                 415     


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
            420                 425                 430         


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
    450                 455                 460                 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
465                 470                 475                 480 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
                485                 490                 495     


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
            500                 505                 510         


Lys Leu Glu Leu Lys 
        515         


<210>  261
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  261

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510     


<210>  262
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  262

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                405                 410                 415     


Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu 
            420                 425                 430         


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala 
    450                 455                 460                 


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp 
                485                 490                 495     


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe 
            500                 505                 510         


Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Glu Leu 
        515                 520                 


<210>  263
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  263

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  264
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  264

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
385                 390                 395                 400 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                405                 410                 415     


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
                485                 490                 495     


Lys Leu Glu Leu Lys Asp Glu Leu 
            500                 


<210>  265
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  265

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile 
                405                 410                 415     


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


Asp Glu Leu 
        515 


<210>  266
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  266

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr 
    370                 375                 380                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu 
385                 390                 395                 400 


Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
                405                 410                 415     


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
        435                 440                 445             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly 
                485                 490                 495     


Thr Lys Leu Glu Leu Lys Asp Glu Leu 
            500                 505 


<210>  267
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  267

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe 
        355                 360                 365             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser 
385                 390                 395                 400 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
                405                 410                 415     


Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
            420                 425                 430         


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
    450                 455                 460                 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro 
465                 470                 475                 480 


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp Glu Leu 
                485                 490                 495 


<210>  268
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  268

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln Gln Pro Gly Ala 
            260                 265                 270         


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser 
        275                 280                 285             


Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val Lys Gln Thr Pro 
    290                 295                 300                 


Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp 
305                 310                 315                 320 


Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
                325                 330                 335     


Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
            340                 345                 350         


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser 
        355                 360                 365             


Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser 
                405                 410                 415     


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
            420                 425                 430         


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
        435                 440                 445             


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
    450                 455                 460                 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
465                 470                 475                 480 


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
                485                 490                 495     


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
            500                 505                 510         


Lys Leu Glu Leu Lys Asp Glu Leu 
        515                 520 


<210>  269
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  269

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Asp 
            500                 505                 510         


Glu Leu 
        


<210>  270
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  270

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
305                 310                 315                 320 


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
        355                 360                 365             


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
385                 390                 395                 400 


Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His 
            420                 425                 430         


Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln 
        435                 440                 445             


Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val 
    450                 455                 460                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
465                 470                 475                 480 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln 
                485                 490                 495     


Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            500                 505                 510         


Lys 
    


<210>  271
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  271

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        275                 280                 285             


Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly 
305                 310                 315                 320 


Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile 
    370                 375                 380                 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
385                 390                 395                 400 


Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly 
                405                 410                 415     


Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
            420                 425                 430         


Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg 
        435                 440                 445             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
    450                 455                 460                 


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu 
465                 470                 475                 480 


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Glu 
                485                 490                 495     


Leu 
    


<210>  272
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  272

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
305                 310                 315                 320 


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
        355                 360                 365             


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
                405                 410                 415     


Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile 
            420                 425                 430         


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
        435                 440                 445             


Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
    450                 455                 460                 


Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
                485                 490                 495     


Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr 
            500                 505                 510         


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        515                 520             


<210>  273
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  273

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
305                 310                 315                 320 


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
        355                 360                 365             


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu 
385                 390                 395                 400 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
                405                 410                 415     


Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
            420                 425                 430         


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser 
        435                 440                 445             


Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    450                 455                 460                 


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
465                 470                 475                 480 


Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly 
                485                 490                 495     


Gly Thr Lys Val Glu Ile Lys 
            500             


<210>  274
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  274

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
305                 310                 315                 320 


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
        355                 360                 365             


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
385                 390                 395                 400 


Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His 
            420                 425                 430         


Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln 
        435                 440                 445             


Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly Val 
    450                 455                 460                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
465                 470                 475                 480 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln 
                485                 490                 495     


Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            500                 505                 510         


Lys Asp Glu Leu 
        515     


<210>  275
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  275

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr 
            260                 265                 270         


Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile 
        275                 280                 285             


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
    290                 295                 300                 


Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
305                 310                 315                 320 


Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
            340                 345                 350         


Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr 
        355                 360                 365             


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Val Gln Leu Val Gln 
385                 390                 395                 400 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
                405                 410                 415     


Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg 
            420                 425                 430         


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly 
        435                 440                 445             


Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile 
    450                 455                 460                 


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
465                 470                 475                 480 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp 
                485                 490                 495     


Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ser 
    


<210>  276
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  276

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
            260                 265                 270         


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu 
        275                 280                 285             


His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly 
305                 310                 315                 320 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala 
            340                 345                 350         


Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
        355                 360                 365             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
385                 390                 395                 400 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
                405                 410                 415     


Cys Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val 
            420                 425                 430         


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro 
        435                 440                 445             


Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr 
    450                 455                 460                 


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
465                 470                 475                 480 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe 
                485                 490                 495     


Asp Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            500                 505                 510         


Ser Ser 
        


<210>  277
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  277

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
            260                 265                 270         


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu 
        275                 280                 285             


His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Val Ser Gly 
305                 310                 315                 320 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala 
            340                 345                 350         


Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
        355                 360                 365             


Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
    370                 375                 380                 


Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser 
385                 390                 395                 400 


Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro 
                405                 410                 415     


Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp 
            420                 425                 430         


Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp 
        435                 440                 445             


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
    450                 455                 460                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp 
465                 470                 475                 480 


Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490                 


<210>  278
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  278

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr Gln Thr Pro Leu 
            260                 265                 270         


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        275                 280                 285             


Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
    290                 295                 300                 


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser 
305                 310                 315                 320 


Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            340                 345                 350         


Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
385                 390                 395                 400 


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                405                 410                 415     


Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr 
        435                 440                 445             


Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
    450                 455                 460                 


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu 
                485                 490                 495     


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 


<210>  279
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  279

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr 
            260                 265                 270         


Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile 
        275                 280                 285             


Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
    290                 295                 300                 


Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
305                 310                 315                 320 


Tyr Gln Met Ser Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
            340                 345                 350         


Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr 
        355                 360                 365             


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Val Gln Leu Val Gln 
385                 390                 395                 400 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
                405                 410                 415     


Lys Ala Ser Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg 
            420                 425                 430         


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly 
        435                 440                 445             


Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile 
    450                 455                 460                 


Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
465                 470                 475                 480 


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp 
                485                 490                 495     


Gly Tyr Trp Leu Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ser 
    


<210>  280
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  280

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr Gln Thr Pro Leu 
            260                 265                 270         


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
        275                 280                 285             


Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr 
    290                 295                 300                 


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser 
305                 310                 315                 320 


Asn Leu Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            340                 345                 350         


Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu Pro Tyr Thr Phe Gly Gly 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
385                 390                 395                 400 


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                405                 410                 415     


Tyr Ala Phe Ser Tyr Ser Trp Ile Asn Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Gln Gly Leu Glu Trp Met Gly Arg Ile Phe Pro Gly Asp Gly Asp Thr 
        435                 440                 445             


Asp Tyr Asn Gly Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
    450                 455                 460                 


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Arg Asn Val Phe Asp Gly Tyr Trp Leu 
                485                 490                 495     


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 


<210>  281
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  281

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu 
385                 390                 395                 400 


Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln 
            420                 425                 430         


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
        435                 440                 445             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
465                 470                 475                 480 


Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp 
                485                 490                 495     


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510 


<210>  282
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  282

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Gly Gly Gly Ser Gln Ala Tyr Leu Gln 
    370                 375                 380                 


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
                405                 410                 415     


Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
            420                 425                 430         


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
    450                 455                 460                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr 
465                 470                 475                 480 


Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
                485                 490                 495     


Val Thr Val Ser 
            500 


<210>  283
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  283

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu 
385                 390                 395                 400 


Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln 
            420                 425                 430         


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
        435                 440                 445             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
465                 470                 475                 480 


Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp 
                485                 490                 495     


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510 


<210>  284
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  284

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu 
385                 390                 395                 400 


Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln 
            420                 425                 430         


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
        435                 440                 445             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
465                 470                 475                 480 


Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp 
                485                 490                 495     


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510 


<210>  285
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  285

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
            260                 265                 270         


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
        275                 280                 285             


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
    290                 295                 300                 


Ile Tyr Ala Pro Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
305                 310                 315                 320 


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
                325                 330                 335     


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro 
            340                 345                 350         


Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu 
385                 390                 395                 400 


Leu Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
                405                 410                 415     


Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg 
            420                 425                 430         


Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr 
        435                 440                 445             


Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
465                 470                 475                 480 


Ser Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr 
                485                 490                 495     


Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510     


<210>  286
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  286

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Val Leu Ser 
            260                 265                 270         


Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
        275                 280                 285             


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 
    290                 295                 300                 


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Pro Ser Asn Leu 
305                 310                 315                 320 


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
                325                 330                 335     


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr Phe Gly Ala Gly Thr 
        355                 360                 365             


Lys Leu Glu Leu Lys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu 
385                 390                 395                 400 


Val Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
                405                 410                 415     


Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln 
            420                 425                 430         


Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser 
        435                 440                 445             


Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
465                 470                 475                 480 


Ala Val Tyr Phe Cys Ala Arg Val Val Tyr Tyr Ser Asn Ser Tyr Trp 
                485                 490                 495     


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 
            500                 505                 510 


<210>  287
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  287

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
        275                 280                 285             


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
305                 310                 315                 320 


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly 
        435                 440                 445             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    450                 455                 460                 


Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
465                 470                 475                 480 


Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr 
                485                 490                 495     


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Lys 
            500                 505                 510         


Asp Glu Leu 
        515 


<210>  288
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  288

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        275                 280                 285             


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    290                 295                 300                 


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp 
            340                 345                 350         


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile 
        435                 440                 445             


Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr 
                485                 490                 495     


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505                 510         


<210>  289
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  289

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        275                 280                 285             


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    290                 295                 300                 


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp 
            340                 345                 350         


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile 
        435                 440                 445             


Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr 
                485                 490                 495     


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505                 510         


<210>  290
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  290

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile 
                245                 250                 255     


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
            260                 265                 270         


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
        275                 280                 285             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp 
    290                 295                 300                 


Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
                325                 330                 335     


Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe 
            340                 345                 350         


Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly 
        355                 360                 365             


Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    370                 375                 380                 


Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
385                 390                 395                 400 


Ser Gly Phe Thr Phe Asn Asp Tyr Ala Met His Trp Val Arg Gln Ala 
                405                 410                 415     


Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Trp Asn Ser Gly 
            420                 425                 430         


Ser Ile Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        435                 440                 445             


Asp Asn Ala Lys Lys Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    450                 455                 460                 


Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn 
465                 470                 475                 480 


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210>  291
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  291

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
            260                 265                 270         


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
        275                 280                 285             


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    290                 295                 300                 


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp 
            340                 345                 350         


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Gly 
        355                 360                 365             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    370                 375                 380                 


Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
385                 390                 395                 400 


Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                405                 410                 415     


Trp Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp 
            420                 425                 430         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser 
        435                 440                 445             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr 
    450                 455                 460                 


Tyr Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp 
465                 470                 475                 480 


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                485                 490         


<210>  292
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  292

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Glu Phe Pro Lys Pro Ser Thr Pro Pro 
                245                 250                 255     


Gly Ser Ser Gly Gly Ala Pro Glu Ile Val Leu Thr Gln Ser Pro Ala 
            260                 265                 270         


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        275                 280                 285             


Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    290                 295                 300                 


Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly 
305                 310                 315                 320 


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                325                 330                 335     


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
            340                 345                 350         


Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu 
        355                 360                 365             


Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    370                 375                 380                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
385                 390                 395                 400 


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp 
                405                 410                 415     


Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            420                 425                 430         


Val Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser 
        435                 440                 445             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu 
    450                 455                 460                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr 
465                 470                 475                 480 


Cys Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val 
                485                 490                 495     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505         


<210>  293
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  293

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
        355                 360                 365             


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
385                 390                 395                 400 


Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
                405                 410                 415     


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            500                 505                 510         


<210>  294
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  294

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val 
385                 390                 395                 400 


Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val 
                405                 410                 415     


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe 
            420                 425                 430         


Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser 
        435                 440                 445             


Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly 
    450                 455                 460                 


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
465                 470                 475                 480 


Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly 
                485                 490                 495     


Gly Thr Lys Leu Glu Ile Lys 
            500             


<210>  295
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  295

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Val 
385                 390                 395                 400 


Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val 
                405                 410                 415     


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe 
            420                 425                 430         


Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser 
        435                 440                 445             


Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly 
    450                 455                 460                 


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
465                 470                 475                 480 


Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly 
                485                 490                 495     


Gly Thr Lys Leu Glu Ile Lys 
            500             


<210>  296
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  296

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    370                 375                 380                 


Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala 
385                 390                 395                 400 


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
                405                 410                 415     


Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
            420                 425                 430         


Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
        435                 440                 445             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val 
    450                 455                 460                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn 
465                 470                 475                 480 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                485                 490             


<210>  297
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  297

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
        355                 360                 365             


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Lys Gly 
                405                 410                 415     


Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
            420                 425                 430         


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
        435                 440                 445             


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
    450                 455                 460                 


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
                485                 490                 495     


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
            500                 505                 510         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Asp Glu Leu 
        515                 520                 525 


<210>  298
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  298

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    370                 375                 380                 


Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala 
385                 390                 395                 400 


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
                405                 410                 415     


Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
            420                 425                 430         


Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
        435                 440                 445             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val 
    450                 455                 460                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn 
465                 470                 475                 480 


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                485                 490             


<210>  299
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  299

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ala Gln Leu 
        355                 360                 365             


Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
385                 390                 395                 400 


Glu Gly Ser Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala 
                405                 410                 415     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
            420                 425                 430         


Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
        435                 440                 445             


Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val 
465                 470                 475                 480 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn 
                485                 490                 495     


Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 


<210>  300
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  300

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ala Gln Leu 
        355                 360                 365             


Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Ser Gln Ser 
385                 390                 395                 400 


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                405                 410                 415     


Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu 
                485                 490                 495     


Glu Leu Lys 
            


<210>  301
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  301

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Gly Gly Gly Gly Ser Gly Gly Gln Val 
                245                 250                 255     


Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
            260                 265                 270         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 
        275                 280                 285             


His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala 
    290                 295                 300                 


Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 
305                 310                 315                 320 


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
                325                 330                 335     


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            340                 345                 350         


Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Asp Ile Val Leu Ser Gln Ser Pro Ala Ile 
385                 390                 395                 400 


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
                405                 410                 415     


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
            420                 425                 430         


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    450                 455                 460                 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
465                 470                 475                 480 


Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                485                 490                 495     


<210>  302
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  302

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
        355                 360                 365             


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ala Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
385                 390                 395                 400 


Glu Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
                405                 410                 415     


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser 
        435                 440                 445             


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
    450                 455                 460                 


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            500                 505                 510         


<210>  303
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  303

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
        355                 360                 365             


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
    370                 375                 380                 


Thr Val Ser Ala Gly Gly Gly Gly Ser Thr Lys Gly Gln Ile Val Leu 
385                 390                 395                 400 


Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr 
                405                 410                 415     


Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln 
            420                 425                 430         


Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn 
        435                 440                 445             


Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe Gly Gly Gly 
                485                 490                 495     


Thr Lys Leu Glu Ile Lys 
            500         


<210>  304
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  304

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln 
305                 310                 315                 320 


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                325                 330                 335     


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
        355                 360                 365             


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Thr Lys Gly Gln Ile Val Leu Ser Gln Ser Pro Ala 
                405                 410                 415     


Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala 
            420                 425                 430         


Ser Ser Ser Val Ser Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser 
        435                 440                 445             


Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val 
    450                 455                 460                 


Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
465                 470                 475                 480 


Ile Ser Arg Val Glu Ala Glu Asp Lys Asp Glu Leu 
                485                 490         


<210>  305
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  305

Lys Asp Glu Leu 
1               


<210>  306
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  306

His Asp Glu Phe 
1               


<210>  307
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  307

His Asp Glu Leu 
1               


<210>  308
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  308

Arg Asp Glu Phe 
1               


<210>  309
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  309

Arg Asp Glu Leu 
1               


<210>  310
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  310

Trp Asp Glu Leu 
1               


<210>  311
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  311

Tyr Asp Glu Leu 
1               


<210>  312
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  312

His Glu Glu Phe 
1               


<210>  313
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  313

His Glu Glu Leu 
1               


<210>  314
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  314

Lys Glu Glu Leu 
1               


<210>  315
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  315

Arg Glu Glu Leu 
1               


<210>  316
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  316

Lys Ala Glu Leu 
1               


<210>  317
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  317

Lys Cys Glu Leu 
1               


<210>  318
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  318

Lys Phe Glu Leu 
1               


<210>  319
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  319

Lys Gly Glu Leu 
1               


<210>  320
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  320

Lys His Glu Leu 
1               


<210>  321
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  321

Lys Leu Glu Leu 
1               


<210>  322
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  322

Lys Asn Glu Leu 
1               


<210>  323
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  323

Lys Gln Glu Leu 
1               


<210>  324
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  324

Lys Arg Glu Leu 
1               


<210>  325
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  325

Lys Ser Glu Leu 
1               


<210>  326
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  326

Lys Val Glu Leu 
1               


<210>  327
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  327

Lys Trp Glu Leu 
1               


<210>  328
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  328

Lys Tyr Glu Leu 
1               


<210>  329
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  329

Lys Glu Asp Leu 
1               


<210>  330
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  330

Lys Ile Glu Leu 
1               


<210>  331
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  331

Asp Lys Glu Leu 
1               


<210>  332
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  332

Phe Asp Glu Leu 
1               


<210>  333
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  333

Lys Asp Glu Phe 
1               


<210>  334
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  334

Lys Lys Glu Leu 
1               


<210>  335
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  335

His Ala Asp Leu 
1               


<210>  336
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  336

His Ala Glu Leu 
1               


<210>  337
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  337

His Ile Glu Leu 
1               


<210>  338
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  338

His Asn Glu Leu 
1               


<210>  339
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  339

His Thr Glu Leu 
1               


<210>  340
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  340

Lys Thr Glu Leu 
1               


<210>  341
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  341

His Val Glu Leu 
1               


<210>  342
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  342

Asn Asp Glu Leu 
1               


<210>  343
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  343

Gln Asp Glu Leu 
1               


<210>  344
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  344

Arg Glu Asp Leu 
1               


<210>  345
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  345

Arg Asn Glu Leu 
1               


<210>  346
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  346

Arg Thr Asp Leu 
1               


<210>  347
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  347

Arg Thr Glu Leu 
1               


<210>  348
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  348

Ser Asp Glu Leu 
1               


<210>  349
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  349

Thr Asp Glu Leu 
1               


<210>  350
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  350

Ser Lys Glu Leu 
1               


<210>  351
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  351

Ser Thr Glu Leu 
1               


<210>  352
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  352

Glu Asp Glu Leu 
1               


<210>  353
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  353

Ala Ser Gly Gly Pro Glu 
1               5       


<210>  354
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(52)
<223>  This region may encompass 1-10 'Gly(2-4)Ser' repeating units

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (25)..(26)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (30)..(31)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (35)..(36)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (40)..(41)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (45)..(46)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (50)..(51)
<223>  May or may not be present

<400>  354

Ala Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Ala Met 
    50                  


<210>  355
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(210)
<223>  This sequence may encompass 1-30 '(Gly)X-Ser' repeating units, 
       wherein X represents 1-6

<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (9)..(13)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (23)..(27)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (30)..(34)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (37)..(41)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (44)..(48)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (58)..(62)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (65)..(69)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (72)..(76)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (79)..(83)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (93)..(97)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (100)..(104)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (107)..(111)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (114)..(118)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (121)..(125)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (128)..(132)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (135)..(139)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (142)..(146)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (149)..(153)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (156)..(160)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (163)..(167)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (170)..(174)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (177)..(181)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (184)..(188)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (191)..(195)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (198)..(202)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (205)..(209)
<223>  May or may not be present

<400>  355

Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Ser 
    210 


<210>  356
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(210)
<223>  This sequence may encompass 1-30 '(Ser)X-Gly' repeating units, 
       wherein X represents 1-6

<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (9)..(13)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (23)..(27)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (30)..(34)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (37)..(41)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (44)..(48)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (51)..(55)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (58)..(62)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (65)..(69)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (72)..(76)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (79)..(83)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (86)..(90)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (93)..(97)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (100)..(104)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (107)..(111)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (114)..(118)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (121)..(125)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (128)..(132)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (135)..(139)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (142)..(146)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (149)..(153)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (156)..(160)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (163)..(167)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (170)..(174)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (177)..(181)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (184)..(188)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (191)..(195)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (198)..(202)
<223>  May or may not be present

<220>
<221>  MISC_FEATURE
<222>  (205)..(209)
<223>  May or may not be present

<400>  356

Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
    50                  55                  60                  


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly 
            100                 105                 110         


Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser 
        115                 120                 125             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
                165                 170                 175     


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Gly 
    210 


<210>  357
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(150)
<223>  This sequence may encompass 1-30 'Gly-Gly-Gly- Gly-Ser' repeating
       units

<400>  357

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210>  358
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(30)
<223>  May or may not be present

<400>  358

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30  


<210>  359
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  359

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  360
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  360

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210>  361
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  361

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  362
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  362

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  363
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  363

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  364
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  364

Ser Arg Ser Ser Gly 
1               5   


<210>  365
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  365

Ser Gly Ser Ser Cys 
1               5   


<210>  366
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  366

Ala Met Gly Arg Ser Gly Gly Gly Cys Ala Gly Asn Arg Val Gly Ser 
1               5                   10                  15      


Ser Leu Ser Cys Gly Gly Leu Asn Leu Gln Ala Met 
            20                  25              


<210>  367
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  367

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  368
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  368

Gly Gly Gly Ser 
1               


<210>  369
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  369

Gly Gly Gly Gly Ser Gly Gly Gly 
1               5               


<210>  370
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  370

Gly Gly Ser Gly Gly Gly Gly 
1               5           


<210>  371
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  371

Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser 
        


<210>  372
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  372

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Ser Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  373
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  373

Gly Gly Gly Gly Cys 
1               5   


<210>  374
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  374

Ser Gly Gly Gly Gly Cys 
1               5       


<210>  375
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  375

Met Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys 
                245 


<210>  376
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  376

Met Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  377
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  377

Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  378
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  378

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
1               5                   10                  15  


<210>  379
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  379

Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro 
1               5                   10                  15      


<210>  380
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  380

Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr 
1               5                   10                  15      


Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val 
            20                  25                  30          


Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly 
        35                  40                  45              


Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser 
    50                  55                  60                  


Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val 
65                  70                  75                  80  


Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg 
                85                  90                  95      


Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser 
            100                 105                 110         


Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn 
        115                 120                 125             


Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser 
    130                 135                 140                 


Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly 
145                 150                 155                 160 


Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala 
                165                 170                 175     


Arg 
    


<210>  381
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  381

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn 
    


<210>  382
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  382

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210>  383
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  383

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys 
            260     


<210>  384
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  384

Asn Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr 
1               5                   10                  15      


Arg Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val 
            20                  25                  30          


Thr Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly 
        35                  40                  45              


Ile Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser 
    50                  55                  60                  


Tyr Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val 
65                  70                  75                  80  


Ala Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg 
                85                  90                  95      


Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser 
            100                 105                 110         


Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn 
        115                 120                 125             


Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser 
    130                 135                 140                 


Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly 
145                 150                 155                 160 


Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala 
                165                 170                 175     


Arg 
    


<210>  385
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  385

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn 
    


<210>  386
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  386

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210>  387
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  387

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys 
            260     


<210>  388
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  388

Asn Leu Tyr Val Ala Gly Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr 
1               5                   10                  15      


Arg Phe Ser Asp Phe Ser His Ile Ser Val Pro Asp Val Ile Thr Val 
            20                  25                  30          


Ser Met Thr Thr Asp Ser Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp 
        35                  40                  45              


Leu Glu Arg Thr Gly Met Gln Ile Gly Arg His Ser Leu Val Gly Ser 
    50                  55                  60                  


Tyr Leu Asp Leu Met Glu Phe Arg Gly Arg Ser Met Thr Arg Ala Ser 
65                  70                  75                  80  


Ser Arg Ala Met Leu Arg Phe Val Thr Val Ile Ala Glu Ala Leu Arg 
                85                  90                  95      


Phe Arg Gln Ile Gln Arg Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser 
            100                 105                 110         


Pro Leu Tyr Thr Met Thr Ala Gln Asp Val Asp Leu Thr Leu Asn Trp 
        115                 120                 125             


Gly Arg Ile Ser Asn Val Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val 
    130                 135                 140                 


Arg Ile Gly Arg Ile Ser Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser 
145                 150                 155                 160 


Val Ala Val Ile Leu Asn Cys His Ser Thr Gly Ser Tyr Ser Val Arg 
                165                 170                 175     


Ser 
    


<210>  389
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  389

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Leu Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys 
    


<210>  390
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  390

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Leu Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg Ser 
                245                 250     


<210>  391
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  391

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Leu Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg Ser Val Ser Gln Lys Gln 
                245                 250                 255     


Lys Thr Glu Cys Gln 
            260     


