                         SEQUENCE LISTING

<110>  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
       WANTUCH, Paeton  L.
       DUKE, Jeremy A.
       AVCI, Fikri Y.
 
<120>  TETANUS TOXOID AND CRM-BASED PEPTIDES AND METHODS OF USE

<130>  0235.000289WO01

<140>  PCT/US20/61699
<141>  2020-11-22

<150>  US 62/939,299
<151>  2019-11-22

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  1315
<212>  PRT
<213>  Clostridium tetani

<400>  1

Met Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val Asn Asn 
1               5                   10                  15      


Asp Thr Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu Asp Ile 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Val Pro Glu 
        35                  40                  45              


Arg Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn Pro Pro Ser Ser 
    50                  55                  60                  


Leu Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro Asn Tyr Leu Arg Thr 
65                  70                  75                  80  


Asp Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu Phe Asn 
                85                  90                  95      


Arg Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu Asp Lys Ile Ile 
            100                 105                 110         


Asn Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser Leu Leu Asp Lys Phe 
        115                 120                 125             


Asp Thr Asn Ser Asn Ser Val Ser Phe Asn Leu Leu Glu Gln Asp Pro 
    130                 135                 140                 


Ser Gly Ala Thr Thr Lys Ser Ala Met Leu Thr Asn Leu Ile Ile Phe 
145                 150                 155                 160 


Gly Pro Gly Pro Val Leu Asn Lys Asn Glu Val Arg Gly Ile Val Leu 
                165                 170                 175     


Arg Val Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe Gly Ser 
            180                 185                 190         


Ile Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro Thr Phe Asp Asn 
        195                 200                 205             


Val Ile Glu Asn Ile Thr Ser Leu Thr Ile Gly Lys Ser Lys Tyr Phe 
    210                 215                 220                 


Gln Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His 
225                 230                 235                 240 


Gly Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile Pro Ser Lys 
                245                 250                 255     


Gln Glu Ile Tyr Met Gln His Thr Tyr Pro Ile Ser Ala Glu Glu Leu 
            260                 265                 270         


Phe Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys 
        275                 280                 285             


Asn Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn 
    290                 295                 300                 


Lys Leu Ser Gln Val Thr Ser Cys Asn Asp Pro Asn Ile Asp Ile Asp 
305                 310                 315                 320 


Ser Tyr Lys Gln Ile Tyr Gln Gln Lys Tyr Gln Phe Asp Lys Asp Ser 
                325                 330                 335     


Asn Gly Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln Ile Leu Tyr Asn 
            340                 345                 350         


Ser Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly Lys Lys Phe Asn 
        355                 360                 365             


Ile Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His Asp Pro Val Lys 
    370                 375                 380                 


Ile Pro Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp Thr Glu Gly Phe 
385                 390                 395                 400 


Asn Ile Glu Ser Lys Asp Leu Lys Ser Glu Tyr Lys Gly Gln Asn Met 
                405                 410                 415     


Arg Val Asn Thr Asn Ala Phe Arg Asn Val Asp Gly Ser Gly Leu Val 
            420                 425                 430         


Ser Lys Leu Ile Gly Leu Cys Lys Lys Ile Ile Pro Pro Thr Asn Ile 
        435                 440                 445             


Arg Glu Asn Leu Tyr Asn Arg Thr Ala Ser Leu Thr Asp Leu Gly Gly 
    450                 455                 460                 


Glu Leu Cys Ile Lys Ile Lys Asn Glu Asp Leu Thr Phe Ile Ala Glu 
465                 470                 475                 480 


Lys Asn Ser Phe Ser Glu Glu Pro Phe Gln Asp Glu Ile Val Ser Tyr 
                485                 490                 495     


Asn Thr Lys Asn Lys Pro Leu Asn Phe Asn Tyr Ser Leu Asp Lys Ile 
            500                 505                 510         


Ile Val Asp Tyr Asn Leu Gln Ser Lys Ile Thr Leu Pro Asn Asp Arg 
        515                 520                 525             


Thr Thr Pro Val Thr Lys Gly Ile Pro Tyr Ala Pro Glu Tyr Lys Ser 
    530                 535                 540                 


Asn Ala Ala Ser Thr Ile Glu Ile His Asn Ile Asp Asp Asn Thr Ile 
545                 550                 555                 560 


Tyr Gln Tyr Leu Tyr Ala Gln Lys Ser Pro Thr Thr Leu Gln Arg Ile 
                565                 570                 575     


Thr Met Thr Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile 
            580                 585                 590         


Tyr Ser Tyr Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala Gln 
        595                 600                 605             


Gly Ile Leu Phe Leu Gln Trp Val Arg Asp Ile Ile Asp Asp Phe Thr 
    610                 615                 620                 


Asn Glu Ser Ser Gln Lys Thr Thr Ile Asp Lys Ile Ser Asp Val Ser 
625                 630                 635                 640 


Thr Ile Val Pro Tyr Ile Gly Pro Ala Leu Asn Ile Val Lys Gln Gly 
                645                 650                 655     


Tyr Glu Gly Asn Phe Ile Gly Ala Leu Glu Thr Thr Gly Val Val Leu 
            660                 665                 670         


Leu Leu Glu Tyr Ile Pro Glu Ile Thr Leu Pro Val Ile Ala Ala Leu 
        675                 680                 685             


Ser Ile Ala Glu Ser Ser Thr Gln Lys Glu Lys Ile Ile Lys Thr Ile 
    690                 695                 700                 


Asp Asn Phe Leu Glu Lys Arg Tyr Glu Lys Trp Ile Glu Val Tyr Lys 
705                 710                 715                 720 


Leu Val Lys Ala Lys Trp Leu Gly Thr Val Asn Thr Gln Phe Gln Lys 
                725                 730                 735     


Arg Ser Tyr Gln Met Tyr Arg Ser Leu Glu Tyr Gln Val Asp Ala Ile 
            740                 745                 750         


Lys Lys Ile Ile Asp Tyr Glu Tyr Lys Ile Tyr Ser Gly Pro Asp Lys 
        755                 760                 765             


Glu Gln Ile Ala Asp Glu Ile Asn Asn Leu Lys Asn Lys Leu Glu Glu 
    770                 775                 780                 


Lys Ala Asn Lys Ala Met Ile Asn Ile Asn Ile Phe Met Arg Glu Ser 
785                 790                 795                 800 


Ser Arg Ser Phe Leu Val Asn Gln Met Ile Asn Glu Ala Lys Lys Gln 
                805                 810                 815     


Leu Leu Glu Phe Asp Thr Gln Ser Lys Asn Ile Leu Met Gln Tyr Ile 
            820                 825                 830         


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu 
        835                 840                 845             


Ser Lys Ile Asn Lys Val Phe Ser Thr Pro Ile Pro Phe Ser Tyr Ser 
    850                 855                 860                 


Lys Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile 
865                 870                 875                 880 


Leu Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile 
                885                 890                 895     


Ser Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala 
            900                 905                 910         


Gln Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn 
        915                 920                 925             


Glu Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn 
    930                 935                 940                 


Asp Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys 
945                 950                 955                 960 


Val Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile 
                965                 970                 975     


Ile Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser 
            980                 985                 990         


Val Ser Leu Lys Gly Asn Asn Leu  Ile Trp Thr Leu Lys  Asp Ser Ala 
        995                 1000                 1005             


Gly Glu  Val Arg Gln Ile Thr  Phe Arg Asp Leu Pro  Asp Lys Phe 
    1010                 1015                 1020             


Asn Ala  Tyr Leu Ala Asn Lys  Trp Val Phe Ile Thr  Ile Thr Asn 
    1025                 1030                 1035             


Asp Arg  Leu Ser Ser Ala Asn  Leu Tyr Ile Asn Gly  Val Leu Met 
    1040                 1045                 1050             


Gly Ser  Ala Glu Ile Thr Gly  Leu Gly Ala Ile Arg  Glu Asp Asn 
    1055                 1060                 1065             


Asn Ile  Thr Leu Lys Leu Asp  Arg Cys Asn Asn Asn  Asn Gln Tyr 
    1070                 1075                 1080             


Val Ser  Ile Asp Lys Phe Arg  Ile Phe Cys Lys Ala  Leu Asn Pro 
    1085                 1090                 1095             


Lys Glu  Ile Glu Lys Leu Tyr  Thr Ser Tyr Leu Ser  Ile Thr Phe 
    1100                 1105                 1110             


Leu Arg  Asp Phe Trp Gly Asn  Pro Leu Arg Tyr Asp  Thr Glu Tyr 
    1115                 1120                 1125             


Tyr Leu  Ile Pro Val Ala Ser  Ser Ser Lys Asp Val  Gln Leu Lys 
    1130                 1135                 1140             


Asn Ile  Thr Asp Tyr Met Tyr  Leu Thr Asn Ala Pro  Ser Tyr Thr 
    1145                 1150                 1155             


Asn Gly  Lys Leu Asn Ile Tyr  Tyr Arg Arg Leu Tyr  Asn Gly Leu 
    1160                 1165                 1170             


Lys Phe  Ile Ile Lys Arg Tyr  Thr Pro Asn Asn Glu  Ile Asp Ser 
    1175                 1180                 1185             


Phe Val  Lys Ser Gly Asp Phe  Ile Lys Leu Tyr Val  Ser Tyr Asn 
    1190                 1195                 1200             


Asn Asn  Glu His Ile Val Gly  Tyr Pro Lys Asp Gly  Asn Ala Phe 
    1205                 1210                 1215             


Asn Asn  Leu Asp Arg Ile Leu  Arg Val Gly Tyr Asn  Ala Pro Gly 
    1220                 1225                 1230             


Ile Pro  Leu Tyr Lys Lys Met  Glu Ala Val Lys Leu  Arg Asp Leu 
    1235                 1240                 1245             


Lys Thr  Tyr Ser Val Gln Leu  Lys Leu Tyr Asp Asp  Lys Asn Ala 
    1250                 1255                 1260             


Ser Leu  Gly Leu Val Gly Thr  His Asn Gly Gln Ile  Gly Asn Asp 
    1265                 1270                 1275             


Pro Asn  Arg Asp Ile Leu Ile  Ala Ser Asn Trp Tyr  Phe Asn His 
    1280                 1285                 1290             


Leu Lys  Asp Lys Ile Leu Gly  Cys Asp Trp Tyr Phe  Val Pro Thr 
    1295                 1300                 1305             


Asp Glu  Gly Trp Thr Asn Asp  
    1310                 1315 


<210>  2
<211>  535
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  2

Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Glu Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr 
385                 390                 395                 400 


Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His 
                405                 410                 415     


Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val 
            420                 425                 430         


Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr 
        435                 440                 445             


His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile 
    450                 455                 460                 


Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly 
465                 470                 475                 480 


Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser 
                485                 490                 495     


Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu 
            500                 505                 510         


Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser 
        515                 520                 525             


Leu Phe Phe Glu Ile Lys Ser 
    530                 535 


<210>  3
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  3

Leu Phe Asn Arg Ile Lys Asn Asn Val Ala Gly Glu Ala Leu 
1               5                   10                  


<210>  4
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  4

Asn Phe Ile Gly Ala Leu Glu Thr 
1               5               


<210>  5
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  5

Asn Ile Leu Met Gln Tyr Ile Lys Ala Asn Ser Lys 
1               5                   10          


<210>  6
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  6

Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu 
1               5                   10  


<210>  7
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  7

Leu Tyr Asn Gly Leu Lys Phe Ile Ile Lys Arg 
1               5                   10      


<210>  8
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  8

Asp Arg Ile Leu Arg Val Gly Tyr Asn Ala Pro Gly Ile Pro Leu 
1               5                   10                  15  


<210>  9
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  9

Gly Tyr Asn Ala Pro Gly Ile Pro Leu Tyr Lys Lys 
1               5                   10          


<210>  10
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  10

Gly Tyr Val Asp Ser Ile Gln Lys Gly Ile Gln Lys Pro Lys 
1               5                   10                  


<210>  11
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  11

Gly Leu Thr Lys Val Leu Ala Leu Lys Val Asp 
1               5                   10      


<210>  12
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  12

Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser 
1               5                   10                  


<210>  13
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  13

Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly Lys 
1               5                   10                  15      


<210>  14
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  14

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  15
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  15

Gly Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu 
1               5                   10          


<210>  16
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  16

Val Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  17

Tyr Asp Thr Glu Tyr Tyr Leu Ile Pro Val Ala Ser Ser Ser Lys Asp 
1               5                   10                  15      


<210>  18
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  18

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  19
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  19

Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn Glu Ile Asp Ser Phe 
1               5                   10                  15      


<210>  20
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  20

Tyr Asp Pro Asn Tyr Leu Arg Thr Asp Ser Asp Lys Asp Arg Phe Leu 
1               5                   10                  15      


Gln Thr Met Val Lys Leu Phe Asn Arg Ile Lys 
            20                  25          


<210>  21
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  21

Ile Asp Lys Ile Ser Asp Val Ser Thr Ile Val Pro Tyr Ile Gly Pro 
1               5                   10                  15      


Ala Leu Asn Ile 
            20  


<210>  22
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  22

Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
1               5                   10                  15      


Ser His Leu Glu Thr 
            20      


<210>  23
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  23

Pro Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala 
1               5                   10                  15      


Gln Val Ile 
            


<210>  24
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  24

Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
1               5                   10                  15      


Ser Leu Met Val 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  25

Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu 
1               5                   10                  15      


Val Gly Glu Leu 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  26

Val Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn 
1               5                   10                  15      


Leu Phe Gln Val 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  27

Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro 
1               5                   10                  15      


Leu Pro Ile Ala 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  28

Gly Val Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser 
1               5                   10                  15      


Lys Thr His Ile 
            20  


<210>  29
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  29

Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe Gln Val Val His 
1               5                   10                  15      


Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
            20                  25          


<210>  30
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  30

Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn 
1               5                   10                  15      


<210>  31
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide

<400>  31

Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg Lys Ile 
1               5                   10                  15      


<210>  32
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  spacer


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  spacer

<400>  32

Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser Xaa Lys 
1               5                   10                  15      


Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser 
            20                  25                  


<210>  33
<211>  33
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cysteine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  valine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  cysteine

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  valine

<400>  33

Xaa Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser Xaa 
1               5                   10                  15      


Xaa Xaa Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser 
            20                  25                  30          


Xaa 
    


<210>  34
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  spacer

<400>  34

Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser Xaa Lys 
1               5                   10                  15      


Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser Val 
            20                  25                  30  


<210>  35
<211>  32
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  spacer

<400>  35

Cys Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser Xaa 
1               5                   10                  15      


Cys Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser Val 
            20                  25                  30          


<210>  36
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  spacer

<400>  36

Lys Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Ile Gly Ser Xaa Lys 
1               5                   10                  15      


Thr Thr Ala Ala Leu Ser Ile Leu Pro Gly Pro Ile Gly Ser Val 
            20                  25                  30      


<210>  37
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  TT-derived peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  spacer

<400>  37

Xaa Xaa Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu 
1               5                   10          


<210>  38
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  spacer

<400>  38

Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu Xaa Cys Lys Ala Leu Asn 
1               5                   10                  15      


Pro Lys Glu Ile Glu 
            20      


<210>  39
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  CRM-derived peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cysteine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  valine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  valine

<400>  39

Xaa Leu Tyr Asn Gly Leu Lys Phe Ile Ile Lys Arg Xaa Xaa Cys Lys 
1               5                   10                  15      


Ala Leu Asn Pro Lys Glu Ile Glu Xaa 
            20                  25  


<210>  40
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(23)
<223>  spacer

<400>  40

Cys Leu Tyr Asn Gly Leu Lys Phe Ile Ile Lys Arg Xaa Cys Lys Ala 
1               5                   10                  15      


Leu Asn Pro Lys Glu Ile Glu 
            20              


<210>  41
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  TT-derived peptide

<400>  41

Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu 
1               5                   10                  15      


Glu 
    


<210>  42
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  spacer

<400>  42

Gly Phe Leu Gly 
1               


