                         SEQUENCE LISTING

<110>  The Regents of the University of California
       ShangPharma Innovation Inc.
       Renslo, Adam R.
       Arkin, Michelle R.
       Neitz, R. Jeffrey
       Ng, Raymond
       Lee, Peter
 
<120>  Caspase 6 Inhibitors and Uses Thereof

<130>  048536-664001WO

<150>  US 62/939,263
<151>  2019-11-22

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Ser Ser Ala Ser Gly Leu Arg Arg Gly His Pro Ala Gly Gly Glu 
1               5                   10                  15      


Glu Asn Met Thr Glu Thr Asp Ala Phe Tyr Lys Arg Glu Met Phe Asp 
            20                  25                  30          


Pro Ala Glu Lys Tyr Lys Met Asp His Arg Arg Arg Gly Ile Ala Leu 
        35                  40                  45              


Ile Phe Asn His Glu Arg Phe Phe Trp His Leu Thr Leu Pro Glu Arg 
    50                  55                  60                  


Arg Gly Thr Cys Ala Asp Arg Asp Asn Leu Thr Arg Arg Phe Ser Asp 
65                  70                  75                  80  


Leu Gly Phe Glu Val Lys Cys Phe Asn Asp Leu Lys Ala Glu Glu Leu 
                85                  90                  95      


Leu Leu Lys Ile His Glu Val Ser Thr Val Ser His Ala Asp Ala Asp 
            100                 105                 110         


Cys Phe Val Cys Val Phe Leu Ser His Gly Glu Gly Asn His Ile Tyr 
        115                 120                 125             


Ala Tyr Asp Ala Lys Ile Glu Ile Gln Thr Leu Thr Gly Leu Phe Lys 
    130                 135                 140                 


Gly Asp Lys Cys His Ser Leu Val Gly Lys Pro Lys Ile Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Asn Gln His Asp Val Pro Val Ile Pro Leu Asp 
                165                 170                 175     


Val Val Asp Asn Gln Thr Glu Lys Leu Asp Thr Asn Ile Thr Glu Val 
            180                 185                 190         


Asp Ala Ala Ser Val Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu Met 
        195                 200                 205             


Cys Tyr Ser Val Ala Glu Gly Tyr Tyr Ser His Arg Glu Thr Val Asn 
    210                 215                 220                 


Gly Ser Trp Tyr Ile Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly 
225                 230                 235                 240 


Ser Ser Leu Glu Phe Thr Glu Leu Leu Thr Leu Val Asn Arg Lys Val 
                245                 250                 255     


Ser Gln Arg Arg Val Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys 
            260                 265                 270         


Lys Gln Val Pro Cys Phe Ala Ser Met Leu Thr Lys Lys Leu His Phe 
        275                 280                 285             


Phe Pro Lys Ser Asn 
    290             


<210>  2
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  3
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Thr Phe Gln His Lys Glu 
1               5                   10                  15      


Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          


His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              


Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  


Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  


Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      


Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Lys Gln Gly 
            100                 105                 110         


His Leu Glu Asp Met Leu Leu Thr Thr Leu Ser Gly Leu Gln His Val 
        115                 120                 125             


Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro Val 
    130                 135                 140                 


Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Thr Asp Thr 
145                 150                 155                 160 


Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln Val 
                165                 170                 175     


Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr 
            180                 185                 190         


Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
        195                 200                 205             


His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val 
    210                 215                 220                 


Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val 
225                 230                 235                 240 


His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
                245                 250                 255     


Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
            260                 265                 270         


Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
        275                 280                 285             


Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
    290                 295                 300                 


Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
305                 310                 315                 320 


Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp Gly Lys Asn 
                325                 330                 335     


His Ala Gly Ser Pro Gly Cys Glu Glu Ser Asp Ala Gly Lys Glu Lys 
            340                 345                 350         


Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
        355                 360                 365             


Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
    370                 375                 380                 


Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
385                 390                 395                 400 


Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
                405                 410                 415     


Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
            420                 425                 430         


Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
        435                 440                 445             


His Pro Pro Thr 
    450         


