                         SEQUENCE LISTING

<110>  Ionis Pharmaceuticals, Inc.
 
<120>  COMPOUNDS FOR MODULATING BETA GLOBIN EXPRESSION

<130>  BIOL0371WO

<150>  62/939,472
<151>  2019-11-22

<160>  163   

<170>  PatentIn version 3.5

<210>  1
<211>  3001
<212>  DNA
<213>  Homo sapiens

<400>  1
ttgtttccca aaacctaata agtaactaat gcacagagca cattgatttg tatttattct       60

atttttagac ataatttatt agcatgcatg agcaaattaa gaaaaacaac aacaaatgaa      120

tgcatatata tgtatatgta tgtgtgtata tatacacaca tatatatata tattttttct      180

tttcttacca gaaggtttta atccaaataa ggagaagata tgcttagaac cgaggtagag      240

ttttcatcca ttctgtcctg taagtatttt gcatattctg gagacgcagg aagagatcca      300

tctacatatc ccaaagctga attatggtag acaaaactct tccactttta gtgcatcaac      360

ttcttatttg tgtaataaga aaattgggaa aacgatcttc aatatgctta ccaagctgtg      420

attccaaata ttacgtaaat acacttgcaa aggaggatgt ttttagtagc aatttgtact      480

gatggtatgg ggccaagaga tatatcttag agggagggct gagggtttga agtccaactc      540

ctaagccagt gccagaagag ccaaggacag gtacggctgt catcacttag acctcaccct      600

gtggagccac accctagggt tggccaatct actcccagga gcagggaggg caggagccag      660

ggctgggcat aaaagtcagg gcagagccat ctattgctta catttgcttc tgacacaact      720

gtgttcacta gcaacctcaa acagacacca tggtgcatct gactcctgag gagaagtctg      780

ccgttactgc cctgtggggc aaggtgaacg tggatgaagt tggtggtgag gccctgggca      840

ggttggtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg gcatgtggag      900

acagagaaga ctcttgggtt tctgataggc actgactctc tctgcctatt ggtctatttt      960

cccaccctta ggctgctggt ggtctaccct tggacccaga ggttctttga gtcctttggg     1020

gatctgtcca ctcctgatgc tgttatgggc aaccctaagg tgaaggctca tggcaagaaa     1080

gtgctcggtg cctttagtga tggcctggct cacctggaca acctcaaggg cacctttgcc     1140

acactgagtg agctgcactg tgacaagctg cacgtggatc ctgagaactt cagggtgagt     1200

ctatgggacg cttgatgttt tctttcccct tcttttctat ggttaagttc atgtcatagg     1260

aaggggataa gtaacagggt acagtttaga atgggaaaca gacgaatgat tgcatcagtg     1320

tggaagtctc aggatcgttt tagtttcttt tatttgctgt tcataacaat tgttttcttt     1380

tgtttaattc ttgctttctt tttttttctt ctccgcaatt tttactatta tacttaatgc     1440

cttaacattg tgtataacaa aaggaaatat ctctgagata cattaagtaa cttaaaaaaa     1500

aactttacac agtctgccta gtacattact atttggaata tatgtgtgct tatttgcata     1560

ttcataatct ccctacttta ttttctttta tttttaattg atacataatc attatacata     1620

tttatgggtt aaagtgtaat gttttaatat gtgtacacat attgaccaaa tcagggtaat     1680

tttgcatttg taattttaaa aaatgctttc ttcttttaat atactttttt gtttatctta     1740

tttctaatac tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc     1800

tctttgcacc attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatc     1860

tctgcatata aatatttctg catataaatt gtaactgatg taagaggttt catattgcta     1920

atagcagcta caatccagct accattctgc ttttatttta tggttgggat aaggctggat     1980

tattctgagt ccaagctagg cccttttgct aatcatgttc atacctctta tcttcctccc     2040

acagctcctg ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagaattcac     2100

cccaccagtg caggctgcct atcagaaagt ggtggctggt gtggctaatg ccctggccca     2160

caagtatcac taagctcgct ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc     2220

taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg gattctgcct     2280

aataaaaaac atttattttc attgcaatga tgtatttaaa ttatttctga atattttact     2340

aaaaagggaa tgtgggaggt cagtgcattt aaaacataaa gaaatgaaga gctagttcaa     2400

accttgggaa aatacactat atcttaaact ccatgaaaga aggtgaggct gcaaacagct     2460

aatgcacatt ggcaacagcc cctgatgcat atgccttatt catccctcag aaaaggattc     2520

aagtagaggc ttgatttgga ggttaaagtt ttgctatgct gtattttaca ttacttattg     2580

ttttagctgt cctcatgaat gtcttttcac tacccatttg cttatcctgc atctctcagc     2640

cttgactcca ctcagttctc ttgcttagag ataccacctt tcccctgaag tgttccttcc     2700

atgttttacg gcgagatggt ttctcctcgc ctggccactc agccttagtt gtctctgttg     2760

tcttatagag gtctacttga agaaggaaaa acaggggtca tggtttgact gtcctgtgag     2820

cccttcttcc ctgcctcccc cactcacagt gacccggaat ctgcagtgct agtctcccgg     2880

aactatcact ctttcacagt ctgctttgga aggactgggc ttagtatgaa aagttaggac     2940

tgagaagaat ttgaaaggcg gctttttgta gcttgatatt cactactgtc ttattaccct     3000

g                                                                     3001


<210>  2
<211>  3001
<212>  DNA
<213>  Homo sapiens

<400>  2
ttgtttccca aaacctaata agtaactaat gcacagagca cattgatttg tatttattct       60

atttttagac ataatttatt agcatgcatg agcaaattaa gaaaaacaac aacaaatgaa      120

tgcatatata tgtatatgta tgtgtgtata tatacacaca tatatatata tattttttct      180

tttcttacca gaaggtttta atccaaataa ggagaagata tgcttagaac cgaggtagag      240

ttttcatcca ttctgtcctg taagtatttt gcatattctg gagacgcagg aagagatcca      300

tctacatatc ccaaagctga attatggtag acaaaactct tccactttta gtgcatcaac      360

ttcttatttg tgtaataaga aaattgggaa aacgatcttc aatatgctta ccaagctgtg      420

attccaaata ttacgtaaat acacttgcaa aggaggatgt ttttagtagc aatttgtact      480

gatggtatgg ggccaagaga tatatcttag agggagggct gagggtttga agtccaactc      540

ctaagccagt gccagaagag ccaaggacag gtacggctgt catcacttag acctcaccct      600

gtggagccac accctagggt tggccaatct actcccagga gcagggaggg caggagccag      660

ggctgggcat aaaagtcagg gcagagccat ctattgctta catttgcttc tgacacaact      720

gtgttcacta gcaacctcaa acagacacca tggtgcatct gactcctgag gagaagtctg      780

ccgttactgc cctgtggggc aaggtgaacg tggatgaagt tggtggtgag gccctgggca      840

ggttggtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg gcatgtggag      900

acagagaaga ctcttgggtt tctgataggc actgactctc tctgcctatt ggtctatttt      960

cccaccctta ggctgctggt ggtctaccct tggacccaga ggttctttga gtcctttggg     1020

gatctgtcca ctcctgatgc tgttatgggc aaccctaagg tgaaggctca tggcaagaaa     1080

gtgctcggtg cctttagtga tggcctggct cacctggaca acctcaaggg cacctttgcc     1140

acactgagtg agctgcactg tgacaagctg cacgtggatc ctgagaactt cagggtgagt     1200

ctatgggacg cttgatgttt tctttcccct tcttttctat ggttaagttc atgtcatagg     1260

aaggggataa gtaacagggt acagtttaga atgggaaaca gacgaatgat tgcatcagtg     1320

tggaagtctc aggatcgttt tagtttcttt tatttgctgt tcataacaat tgttttcttt     1380

tgtttaattc ttgctttctt tttttttctt ctccgcaatt tttactatta tacttaatgc     1440

cttaacattg tgtataacaa aaggaaatat ctctgagata cattaagtaa cttaaaaaaa     1500

aactttacac agtctgccta gtacattact atttggaata tatgtgtgct tatttgcata     1560

ttcataatct ccctacttta ttttctttta tttttaattg atacataatc attatacata     1620

tttatgggtt aaagtgtaat gttttaatat gtgtacacat attgaccaaa tcagggtaat     1680

tttgcatttg taattttaaa aaatgctttc ttcttttaat atactttttt gtttatctta     1740

tttctaatac tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc     1800

tctttgcacc attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatc     1860

tctgcatata aatatttctg catataaatt gtaactgatg taagaggttt catattgcta     1920

atagcagcta caatccaggt accattctgc ttttatttta tggttgggat aaggctggat     1980

tattctgagt ccaagctagg cccttttgct aatcatgttc atacctctta tcttcctccc     2040

acagctcctg ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagaattcac     2100

cccaccagtg caggctgcct atcagaaagt ggtggctggt gtggctaatg ccctggccca     2160

caagtatcac taagctcgct ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc     2220

taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg gattctgcct     2280

aataaaaaac atttattttc attgcaatga tgtatttaaa ttatttctga atattttact     2340

aaaaagggaa tgtgggaggt cagtgcattt aaaacataaa gaaatgaaga gctagttcaa     2400

accttgggaa aatacactat atcttaaact ccatgaaaga aggtgaggct gcaaacagct     2460

aatgcacatt ggcaacagcc cctgatgcat atgccttatt catccctcag aaaaggattc     2520

aagtagaggc ttgatttgga ggttaaagtt ttgctatgct gtattttaca ttacttattg     2580

ttttagctgt cctcatgaat gtcttttcac tacccatttg cttatcctgc atctctcagc     2640

cttgactcca ctcagttctc ttgcttagag ataccacctt tcccctgaag tgttccttcc     2700

atgttttacg gcgagatggt ttctcctcgc ctggccactc agccttagtt gtctctgttg     2760

tcttatagag gtctacttga agaaggaaaa acaggggtca tggtttgact gtcctgtgag     2820

cccttcttcc ctgcctcccc cactcacagt gacccggaat ctgcagtgct agtctcccgg     2880

aactatcact ctttcacagt ctgctttgga aggactgggc ttagtatgaa aagttaggac     2940

tgagaagaat ttgaaaggcg gctttttgta gcttgatatt cactactgtc ttattaccct     3000

g                                                                     3001


<210>  3
<211>  628
<212>  DNA
<213>  Homo sapiens

<400>  3
acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacacc atggtgcatc       60

tgactcctga ggagaagtct gccgttactg ccctgtgggg caaggtgaac gtggatgaag      120

ttggtggtga ggccctgggc aggctgctgg tggtctaccc ttggacccag aggttctttg      180

agtcctttgg ggatctgtcc actcctgatg ctgttatggg caaccctaag gtgaaggctc      240

atggcaagaa agtgctcggt gcctttagtg atggcctggc tcacctggac aacctcaagg      300

gcacctttgc cacactgagt gagctgcact gtgacaagct gcacgtggat cctgagaact      360

tcaggctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc aaagaattca      420

ccccaccagt gcaggctgcc tatcagaaag tggtggctgg tgtggctaat gccctggccc      480

acaagtatca ctaagctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc      540

ctaagtccaa ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc      600

taataaaaaa catttatttt cattgcaa                                         628


<210>  4
<211>  1667
<212>  DNA
<213>  Homo sapiens

<400>  4
actcccagga gcagggaggg caggagccag ggctgggcat aaaagtcagg gcagagccat       60

ctattgctta catttgcttc tgacacaact gtgttcacta gcaacctcaa acagacacca      120

tggtgcacct gactcctgag gagaagtctg ccgttactgc cctgtggggc aaggtgaacg      180

tggatgaagt tggtggtgag gccctgggca ggttggtatc aaggttacaa gacaggttta      240

aggagaccaa tagaaactgg gcatgtggag acagagaaga ctcttgggtt tctgataggc      300

actgactctc tctgcctatt ggtctatttt cccaccctta ggctgctggt ggtctaccct      360

tggacccaga ggttctttga gtcctttggg gatctgtcca ctcctgatgc tgttatgggc      420

aaccctaagg tgaaggctca tggcaagaaa gtgctcggtg cctttagtga tggcctggct      480

cacctggaca acctcaaggg cacctttgcc acactgagtg agctgcactg tgacaagctg      540

cacgtggatc ctgagaactt cagggtgagt ctatgggacc cttgatgttt tctttcccct      600

tcttttctat ggttaagttc atgtcatagg aaggggagaa gtaacagggt acagtttaga      660

atgggaaaca gacgaatgat tgcatcagtg tggaagtctc aggatcgttt tagtttcttt      720

tatttgctgt tcataacaat tgttttcttt tgtttaattc ttgctttctt tttttttctt      780

ctccgcaatt tttactatta tacttaatgc cttaacattg tgtataacaa aaggaaatat      840

ctctgagata cattaagtaa cttaaaaaaa aactttacac agtctgccta gtacattact      900

atttggaata tatgtgtgct tatttgcata ttcataatct ccctacttta ttttctttta      960

tttttaattg atacataatc attatacata tttatgggtt aaagtgtaat gttttaatat     1020

gtgtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc     1080

ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt     1140

cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga     1200

taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt     1260

gtaactgatg taagaggttt catattgcta atagcagcta caatccaggt accattctgc     1320

ttttatttta tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct     1380

aatcatgttc atacctctta tcttcctccc acagctcctg ggcaacgtgc tggtctgtgt     1440

gctggcccat cactttggca aagaattcac cccaccagtg caggctgcct atcagaaagt     1500

ggtggctggt gtggctaatg ccctggccca caagtatcac taagctcgct ttcttgctgt     1560

ccaatttcta ttaaaggttc ctttgttccc taagtccaac tactaaactg ggggatatta     1620

tgaagggcct tgagcatctg gattctgcct aataaaaaac atttatt                   1667


<210>  5

<400>  5
000

<210>  6
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  6
cacctttgcc acactgagtg a                                                 21


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  7
gcccaggagc ctgaagttct                                                   20


<210>  8
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  8
cactgtgaca agctgcacgt ggatcc                                            26


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  9
gctcacctgg acaacctcaa g                                                 21


<210>  10
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  10
tcattattgc ccctgaagtt ctc                                               23


<210>  11
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  11
cacctttgcc acactgagtg agctgc                                            26


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
ctttccgttg gacccctggg                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
gtgcgcgcga gcccgaaatc                                                   20


<210>  14
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
ggtcaatatg tgtacaca                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
tttggtcaat atgtgtac                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
tgatttggtc aatatgtg                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
ccctgatttg gtcaatat                                                     18


<210>  18
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
aatgcaaaat taccctga                                                     18


<210>  19
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
ttacaaatgc aaaattac                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
gggaaagtat tagaaata                                                     18


<210>  21
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
tagggaaagt attagaaa                                                     18


<210>  22
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
attagggaaa gtattaga                                                     18


<210>  23
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
agattaggga aagtatta                                                     18


<210>  24
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
agagattagg gaaagtat                                                     18


<210>  25
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
tgaaagaaag agattagg                                                     18


<210>  26
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
cctgaaagaa agagatta                                                     18


<210>  27
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
ccctgaaaga aagagatt                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
gccctgaaag aaagagat                                                     18


<210>  29
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
ttgccctgaa agaaagag                                                     18


<210>  30
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
tattgccctg aaagaaag                                                     18


<210>  31
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
cattattgcc ctgaaaga                                                     18


<210>  32
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
tcattattgc cctgaaag                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
atcattattg ccctgaaa                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
tatcattatt gccctgaa                                                     18


<210>  35
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
gtatcattat tgccctga                                                     18


<210>  36
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
tgtatcatta ttgccctg                                                     18


<210>  37
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
ttgtatcatt attgccct                                                     18


<210>  38
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
attgtatcat tattgccc                                                     18


<210>  39
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
cattgtatca ttattgcc                                                     18


<210>  40
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
acattgtatc attattgc                                                     18


<210>  41
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
tacattgtat cattattg                                                     18


<210>  42
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
gatacattgt atcattat                                                     18


<210>  43
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
tgatacattg tatcatta                                                     18


<210>  44
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
atgatacatt gtatcatt                                                     18


<210>  45
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
catgatacat tgtatcat                                                     18


<210>  46
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  46
gcatgataca ttgtatca                                                     18


<210>  47
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  47
ggcatgatac attgtatc                                                     18


<210>  48
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
aggcatgata cattgtat                                                     18


<210>  49
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  49
gaggcatgat acattgta                                                     18


<210>  50
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
agaggcatga tacattgt                                                     18


<210>  51
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  51
aaagaggcat gatacatt                                                     18


<210>  52
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  52
gcaaagaggc atgataca                                                     18


<210>  53
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  53
gtgcaaagag gcatgata                                                     18


<210>  54
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  54
tggtgcaaag aggcatga                                                     18


<210>  55
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  55
aatggtgcaa agaggcat                                                     18


<210>  56
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  56
agaatggtgc aaagaggc                                                     18


<210>  57
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  57
ttagaatggt gcaaagag                                                     18


<210>  58
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  58
ctttagaatg gtgcaaag                                                     18


<210>  59
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  59
ttctttagaa tggtgcaa                                                     18


<210>  60
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  60
tattctttag aatggtgc                                                     18


<210>  61
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  61
gttattcttt agaatggt                                                     18


<210>  62
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  62
ctgttattct ttagaatg                                                     18


<210>  63
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  63
cactgttatt ctttagaa                                                     18


<210>  64
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  64
atcactgtta ttctttag                                                     18


<210>  65
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  65
agaaattatc actgttat                                                     18


<210>  66
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  66
taacccagaa attatcac                                                     18


<210>  67
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  67
cttaacccag aaattatc                                                     18


<210>  68
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  68
gccttaaccc agaaatta                                                     18


<210>  69
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  69
ttgccttaac ccagaaat                                                     18


<210>  70
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  70
tattgcctta acccagaa                                                     18


<210>  71
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  71
gctattgcct taacccag                                                     18


<210>  72
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  72
ttgctattgc cttaaccc                                                     18


<210>  73
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  73
tattgctatt gccttaac                                                     18


<210>  74
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  74
aatattgcta ttgcctta                                                     18


<210>  75
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  75
gaaatattgc tattgcct                                                     18


<210>  76
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  76
cagaaatatt gctattgc                                                     18


<210>  77
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  77
atgcagaaat attgctat                                                     18


<210>  78
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  78
atatgcagaa atattgct                                                     18


<210>  79
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  79
gcagaaatat ttatatgc                                                     18


<210>  80
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  80
ttacaattta tatgcaga                                                     18


<210>  81
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  81
cagttacaat ttatatgc                                                     18


<210>  82
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  82
ctcttacatc agttacaa                                                     18


<210>  83
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  83
acctcttaca tcagttac                                                     18


<210>  84
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  84
aaacctctta catcagtt                                                     18


<210>  85
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  85
tgaaacctct tacatcag                                                     18


<210>  86
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  86
tatgaaacct cttacatc                                                     18


<210>  87
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  87
aatatgaaac ctcttaca                                                     18


<210>  88
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  88
gcaatatgaa acctctta                                                     18


<210>  89
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  89
ctggattgta gctgctat                                                     18


<210>  90
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  90
aatggtacct ggattgta                                                     18


<210>  91
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  91
ataaaagcag aatggtac                                                     18


<210>  92
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  92
tagcaatatg aaacctct                                                     18


<210>  93
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  93
attagcaata tgaaacct                                                     18


<210>  94
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  94
ctattagcaa tatgaaac                                                     18


<210>  95
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  95
ctgctattag caatatga                                                     18


<210>  96
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  96
agctgctatt agcaatat                                                     18


<210>  97
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  97
tagctgctat tagcaata                                                     18


<210>  98
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  98
gtagctgcta ttagcaat                                                     18


<210>  99
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  99
tgtagctgct attagcaa                                                     18


<210>  100
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  100
ttgtagctgc tattagca                                                     18


<210>  101
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  101
attgtagctg ctattagc                                                     18


<210>  102
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  102
gattgtagct gctattag                                                     18


<210>  103
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  103
ggattgtagc tgctatta                                                     18


<210>  104
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  104
tggattgtag ctgctatt                                                     18


<210>  105
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  105
cctggattgt agctgcta                                                     18


<210>  106
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  106
acctggattg tagctgct                                                     18


<210>  107
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  107
tacctggatt gtagctgc                                                     18


<210>  108
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  108
gtacctggat tgtagctg                                                     18


<210>  109
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  109
ggtacctgga ttgtagct                                                     18


<210>  110
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  110
tggtacctgg attgtagc                                                     18


<210>  111
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  111
atggtacctg gattgtag                                                     18


<210>  112
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  112
gaatggtacc tggattgt                                                     18


<210>  113
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  113
agaatggtac ctggattg                                                     18


<210>  114
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  114
cagaatggta cctggatt                                                     18


<210>  115
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  115
gcagaatggt acctggat                                                     18


<210>  116
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  116
agcagaatgg tacctgga                                                     18


<210>  117
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  117
aagcagaatg gtacctgg                                                     18


<210>  118
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  118
aaagcagaat ggtacctg                                                     18


<210>  119
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  119
aaaagcagaa tggtacct                                                     18


<210>  120
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  120
taaaagcaga atggtacc                                                     18


<210>  121
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  121
atcccaacca taaaataa                                                     18


<210>  122
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  122
cttatcccaa ccataaaa                                                     18


<210>  123
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  123
ccttatccca accataaa                                                     18


<210>  124
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  124
gccttatccc aaccataa                                                     18


<210>  125
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  125
agccttatcc caaccata                                                     18


<210>  126
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  126
cagccttatc ccaaccat                                                     18


<210>  127
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  127
ccagccttat cccaacca                                                     18


<210>  128
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  128
tccagcctta tcccaacc                                                     18


<210>  129
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  129
aatccagcct tatcccaa                                                     18


<210>  130
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  130
ataatccagc cttatccc                                                     18


<210>  131
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  131
gaataatcca gccttatc                                                     18


<210>  132
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  132
cagaataatc cagcctta                                                     18


<210>  133
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  133
ctcagaataa tccagcct                                                     18


<210>  134
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  134
gactcagaat aatccagc                                                     18


<210>  135
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  135
tggactcaga ataatcca                                                     18


<210>  136
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  136
cttggactca gaataatc                                                     18


<210>  137
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  137
agcttggact cagaataa                                                     18


<210>  138
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  138
ctagcttgga ctcagaat                                                     18


<210>  139
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  139
gcctagcttg gactcaga                                                     18


<210>  140
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  140
gggcctagct tggactca                                                     18


<210>  141
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  141
aagggcctag cttggact                                                     18


<210>  142
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  142
aaaagggcct agcttgga                                                     18


<210>  143
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  143
gcaaaagggc ctagcttg                                                     18


<210>  144
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  144
tagcaaaagg gcctagct                                                     18


<210>  145
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  145
attagcaaaa gggcctag                                                     18


<210>  146
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  146
atgattagca aaagggcc                                                     18


<210>  147
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  147
acatgattag caaaaggg                                                     18


<210>  148
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  148
gaacatgatt agcaaaag                                                     18


<210>  149
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  149
atgaacatga ttagcaaa                                                     18


<210>  150
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  150
gtatgaacat gattagca                                                     18


<210>  151
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  151
aggtatgaac atgattag                                                     18


<210>  152
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  152
agaggtatga acatgatt                                                     18


<210>  153
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  153
ataagaggta tgaacatg                                                     18


<210>  154
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  154
aagataagag gtatgaac                                                     18


<210>  155
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  155
ggaagataag aggtatga                                                     18


<210>  156
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  156
gaggaagata agaggtat                                                     18


<210>  157
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  157
gggaggaaga taagaggt                                                     18


<210>  158
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  158
gtgggaggaa gataagag                                                     18


<210>  159
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  159
ctgtgggagg aagataag                                                     18


<210>  160
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  160
agctgtggga ggaagata                                                     18


<210>  161
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  161
caggagctgt gggaggaa                                                     18


<210>  162
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  162
gcccaggagc tgtgggag                                                     18


<210>  163
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  163
ttgcccagga gctgtggg                                                     18


