                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
 
<120>  VACCINIA VIRUSES AND METHODS FOR USING VACCINIA VIRUSES

<130>  45049-0033WO1

<140>  PCT/US2020/061578
<141>  2020-11-20

<150>  US 62/938,094
<151>  2019-11-20

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  711
<212>  DNA
<213>  Mus musculus

<400>  1
atggtcagcg ttccaacagc ctcaccctcg gcatccagca gctcctctca gtgccggtcc       60

agcatgtgtc aatcacgcta cctcctcttt ttggccaccc ttgccctcct aaaccacctc      120

agtttggcca gggtcattcc agtctctgga cctgccaggt gtcttagcca gtcccgaaac      180

ctgctgaaga ccacagatga catggtgaag acggccagag aaaaactgaa acattattcc      240

tgcactgctg aagacatcga tcatgaagac atcacacggg accaaaccag cacattgaag      300

acctgtttac cactggaact acacaagaac gagagttgcc tggctactag agagacttct      360

tccacaacaa gagggagctg cctgccccca cagaagacgt ctttgatgat gaccctgtgc      420

cttggtagca tctatgagga cttgaagatg taccagacag agttccaggc catcaacgca      480

gcacttcaga atcacaacca tcagcagatc attctagaca agggcatgct ggtggccatc      540

gatgagctga tgcagtctct gaatcataat ggcgagactc tgcgccagaa acctcctgtg      600

ggagaagcag acccttacag agtgaaaatg aagctctgca tcctgcttca cgccttcagc      660

acccgcgtcg tgaccatcaa cagggtgatg ggctatctga gctccgcctg a               711


<210>  2
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  2

Met Val Ser Val Pro Thr Ala Ser Pro Ser Ala Ser Ser Ser Ser Ser 
1               5                   10                  15      


Gln Cys Arg Ser Ser Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala 
            20                  25                  30          


Thr Leu Ala Leu Leu Asn His Leu Ser Leu Ala Arg Val Ile Pro Val 
        35                  40                  45              


Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr 
    50                  55                  60                  


Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser 
65                  70                  75                  80  


Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr 
                85                  90                  95      


Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser 
            100                 105                 110         


Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu 
        115                 120                 125             


Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile 
    130                 135                 140                 


Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala 
145                 150                 155                 160 


Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met 
                165                 170                 175     


Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu 
            180                 185                 190         


Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val 
        195                 200                 205             


Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val 
    210                 215                 220                 


Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
225                 230                 235     


<210>  3
<211>  1008
<212>  DNA
<213>  Mus musculus

<400>  3
atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtctccactc       60

atggccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg gactcccgat      120

gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga catcacctgg      180

acctcagacc agagacatgg agtcataggc tctggaaaga ccctgaccat cactgtcaaa      240

gagtttctag atgctggcca gtacacctgc cacaaaggag gcgagactct gagccactca      300

catctgctgc tccacaagaa ggaaaatgga atttggtcca ctgaaatttt aaaaaatttc      360

aaaaacaaga ctttcctgaa gtgtgaagca ccaaattact ccggacggtt cacgtgctca      420

tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag cagttcccct      480

gactctcggg cagtgacatg tggaatggcg tctctgtctg cagagaaggt cacactggac      540

caaagggact atgagaagta ttcagtgtcc tgccaggagg atgtcacctg cccaactgcc      600

gaggagaccc tgcccattga actggcgttg gaagcacggc agcagaataa atatgagaac      660

tacagcacca gcttcttcat cagggacatc atcaaaccag acccgcccaa gaacttgcag      720

atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga ctcctggagc      780

actccccatt cctacttctc cctcaagttc tttgttcgaa tccagcgcaa gaaagaaaag      840

atgaaggaga cagaggaggg gtgtaaccag aaaggtgcgt tcctcgtaga gaagacatct      900

accgaagtcc aatgcaaagg cgggaatgtc tgcgtgcaag ctcaggatcg ctattacaat      960

tcctcatgca gcaagtgggc atgtgttccc tgcagggtcc gatcctag                  1008


<210>  4
<211>  335
<212>  PRT
<213>  Mus musculus

<400>  4

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210>  5
<211>  1444
<212>  DNA
<213>  Homo sapiens

<400>  5
tttcattttg ggccgagctg gaggcggcgg ggccgtcccg gaacggctgc ggccgggcac       60

cccgggagtt aatccgaaag cgccgcaagc cccgcgggcc ggccgcaccg cacgtgtcac      120

cgagaagctg atgtagagag agacacagaa ggagacagaa agcaagagac cagagtcccg      180

ggaaagtcct gccgcgcctc gggacaatta taaaaatgtg gccccctggg tcagcctccc      240

agccaccgcc ctcacctgcc gcggccacag gtctgcatcc agcggctcgc cctgtgtccc      300

tgcagtgccg gctcagcatg tgtccagcgc gcagcctcct ccttgtggct accctggtcc      360

tcctggacca cctcagtttg gccagaaacc tccccgtggc cactccagac ccaggaatgt      420

tcccatgcct tcaccactcc caaaacctgc tgagggccgt cagcaacatg ctccagaagg      480

ccagacaaac tctagaattt tacccttgca cttctgaaga gattgatcat gaagatatca      540

caaaagataa aaccagcaca gtggaggcct gtttaccatt ggaattaacc aagaatgaga      600

gttgcctaaa ttccagagag acctctttca taactaatgg gagttgcctg gcctccagaa      660

agacctcttt tatgatggcc ctgtgcctta gtagtattta tgaagacttg aagatgtacc      720

aggtggagtt caagaccatg aatgcaaagc ttctgatgga tcctaagagg cagatctttc      780

tagatcaaaa catgctggca gttattgatg agctgatgca ggccctgaat ttcaacagtg      840

agactgtgcc acaaaaatcc tcccttgaag aaccggattt ttataaaact aaaatcaagc      900

tctgcatact tcttcatgct ttcagaattc gggcagtgac tattgataga gtgatgagct      960

atctgaatgc ttcctaaaaa gcgaggtccc tccaaaccgt tgtcattttt ataaaacttt     1020

gaaatgagga aactttgata ggatgtggat taagaactag ggagggggaa agaaggatgg     1080

gactattaca tccacatgat acctctgatc aagtattttt gacatttact gtggataaat     1140

tgtttttaag ttttcatgaa tgaattgcta agaagggaaa atatccatcc tgaaggtgtt     1200

tttcattcac tttaatagaa gggcaaatat ttataagcta tttctgtacc aaagtgtttg     1260

tggaaacaaa catgtaagca taacttattt taaaatattt atttatataa cttggtaatc     1320

atgaaagcat ctgagctaac ttatatttat ttatgttata tttattaaat tatttatcaa     1380

gtgtatttga aaaatatttt taagtgttct aaaaataaaa gtattgaatt aaagtgaaaa     1440

aaaa                                                                  1444


<210>  6
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  7
<211>  2347
<212>  DNA
<213>  Homo sapiens

<400>  7
ctgtttcagg gccattggac tctccgtcct gcccagagca agatgtgtca ccagcagttg       60

gtcatctctt ggttttccct ggtttttctg gcatctcccc tcgtggccat atgggaactg      120

aagaaagatg tttatgtcgt agaattggat tggtatccgg atgcccctgg agaaatggtg      180

gtcctcacct gtgacacccc tgaagaagat ggtatcacct ggaccttgga ccagagcagt      240

gaggtcttag gctctggcaa aaccctgacc atccaagtca aagagtttgg agatgctggc      300

cagtacacct gtcacaaagg aggcgaggtt ctaagccatt cgctcctgct gcttcacaaa      360

aaggaagatg gaatttggtc cactgatatt ttaaaggacc agaaagaacc caaaaataag      420

acctttctaa gatgcgaggc caagaattat tctggacgtt tcacctgctg gtggctgacg      480

acaatcagta ctgatttgac attcagtgtc aaaagcagca gaggctcttc tgacccccaa      540

ggggtgacgt gcggagctgc tacactctct gcagagagag tcagagggga caacaaggag      600

tatgagtact cagtggagtg ccaggaggac agtgcctgcc cagctgctga ggagagtctg      660

cccattgagg tcatggtgga tgccgttcac aagctcaagt atgaaaacta caccagcagc      720

ttcttcatca gggacatcat caaacctgac ccacccaaga acttgcagct gaagccatta      780

aagaattctc ggcaggtgga ggtcagctgg gagtaccctg acacctggag tactccacat      840

tcctacttct ccctgacatt ctgcgttcag gtccagggca agagcaagag agaaaagaaa      900

gatagagtct tcacggacaa gacctcagcc acggtcatct gccgcaaaaa tgccagcatt      960

agcgtgcggg cccaggaccg ctactatagc tcatcttgga gcgaatgggc atctgtgccc     1020

tgcagttagg ttctgatcca ggatgaaaat ttggaggaaa agtggaagat attaagcaaa     1080

atgtttaaag acacaacgga atagacccaa aaagataatt tctatctgat ttgctttaaa     1140

acgttttttt aggatcacaa tgatatcttt gctgtatttg tatagttaga tgctaaatgc     1200

tcattgaaac aatcagctaa tttatgtata gattttccag ctctcaagtt gccatgggcc     1260

ttcatgctat ttaaatattt aagtaattta tgtatttatt agtatattac tgttatttaa     1320

cgtttgtctg ccaggatgta tggaatgttt catactctta tgacctgatc catcaggatc     1380

agtccctatt atgcaaaatg tgaatttaat tttatttgta ctgacaactt ttcaagcaag     1440

gctgcaagta catcagtttt atgacaatca ggaagaatgc agtgttctga taccagtgcc     1500

atcatacact tgtgatggat gggaacgcaa gagatactta catggaaacc tgacaatgca     1560

aacctgttga gaagatccag gagaacaaga tgctagttcc catgtctgtg aagacttcct     1620

ggagatggtg ttgataaagc aatttagggc cacttacact tctaagcaag tttaatcttt     1680

ggatgcctga attttaaaag ggctagaaaa aaatgattga ccagcctggg aaacataaca     1740

agaccccgtc tctacaaaaa aaatttaaaa ttagccaggc gtggtggctc atgcttgtgg     1800

tcccagctgt tcaggaggat gaggcaggag gatctcttga gcccaggagg tcaaggctat     1860

ggtgagccgt gattgtgcca ctgcatacca gcctaggtga cagaatgaga ccctgtctca     1920

aaaaaaaaaa tgattgaaat taaaattcag ctttagcttc catggcagtc ctcaccccca     1980

cctctctaaa agacacagga ggatgacaca gaaacaccgt aagtgtctgg aaggcaaaaa     2040

gatcttaaga ttcaagagag aggacaagta gttatggcta aggacatgaa attgtcagaa     2100

tggcaggtgg cttcttaaca gccctgtgag aagcagacag atgcaaagaa aatctggaat     2160

ccctttctca ttagcatgaa tgaacctgat acacaattat gaccagaaaa tatggctcca     2220

tgaaggtgct acttttaagt aatgtatgtg cgctctgtaa agtgattaca tttgtttcct     2280

gtttgtttat ttatttattt atttttgcat tctgaggctg aactaataaa aactcttctt     2340

tgtaatc                                                               2347


<210>  8
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  9
<211>  1176
<212>  DNA
<213>  Artificial

<220>
<223>  nucleic acid sequence encoding an IL-12p40-FG polypeptide

<400>  9
atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtctccactc       60

atggccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg gactcccgat      120

gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga catcacctgg      180

acctcagacc agagacatgg agtcataggc tctggaaaga ccctgaccat cactgtcaaa      240

gagtttctag atgctggcca gtacacctgc cacaaaggag gcgagactct gagccactca      300

catctgctgc tccacaagaa ggaaaatgga atttggtcca ctgaaatttt aaaaaatttc      360

aaaaacaaga ctttcctgaa gtgtgaagca ccaaattact ccggacggtt cacgtgctca      420

tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag cagttcccct      480

gactctcggg cagtgacatg tggaatggcg tctctgtctg cagagaaggt cacactggac      540

caaagggact atgagaagta ttcagtgtcc tgccaggagg atgtcacctg cccaactgcc      600

gaggagaccc tgcccattga actggcgttg gaagcacggc agcagaataa atatgagaac      660

tacagcacca gcttcttcat cagggacatc atcaaaccag acccgcccaa gaacttgcag      720

atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga ctcctggagc      780

actccccatt cctacttctc cctcaagttc tttgttcgaa tccagcgcaa gaaagaaaag      840

atgaaggaga cagaggaggg gtgtaaccag aaaggtgcgt tcctcgtaga gaagacatct      900

accgaagtcc aatgcaaagg cgggaatgtc tgcgtgcaag ctcaggatcg ctattacaat      960

tcctcatgca gcaagtgggc atgtgttccc tgcagggtcc gatccgggcc ggccggtggc     1020

ggtgggagcg gtggtggggg ttccggaggc ggagggtcgg tgtcaaccat ctcatcattc     1080

tctccacctg ggtaccaagt ctctttctgc ttggtgatgg tactcctttt tgcagtggac     1140

acaggactat atttctctgt gaagacaaac atttga                               1176


<210>  10
<211>  391
<212>  PRT
<213>  Artificial

<220>
<223>  IL-12p40-FG polypeptide

<400>  10

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly 
                325                 330                 335     


Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val Ser 
        355                 360                 365             


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
    370                 375                 380                 


Phe Ser Val Lys Thr Asn Ile 
385                 390     


<210>  11
<211>  1203
<212>  DNA
<213>  Artificial

<220>
<223>  nucleic acid sequence encoding an IL-12p40-RG polypeptide

<400>  11
atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtctccactc       60

atggccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg gactcccgat      120

gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga catcacctgg      180

acctcagacc agagacatgg agtcataggc tctggaaaga ccctgaccat cactgtcaaa      240

gagtttctag atgctggcca gtacacctgc cacaaaggag gcgagactct gagccactca      300

catctgctgc tccacaagaa ggaaaatgga atttggtcca ctgaaatttt aaaaaatttc      360

aaaaacaaga ctttcctgaa gtgtgaagca ccaaattact ccggacggtt cacgtgctca      420

tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag cagttcccct      480

gactctcggg cagtgacatg tggaatggcg tctctgtctg cagagaaggt cacactggac      540

caaagggact atgagaagta ttcagtgtcc tgccaggagg atgtcacctg cccaactgcc      600

gaggagaccc tgcccattga actggcgttg gaagcacggc agcagaataa atatgagaac      660

tacagcacca gcttcttcat cagggacatc atcaaaccag acccgcccaa gaacttgcag      720

atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga ctcctggagc      780

actccccatt cctacttctc cctcaagttc tttgttcgaa tccagcgcaa gaaagaaaag      840

atgaaggaga cagaggaggg gtgtaaccag aaaggtgcgt tcctcgtaga gaagacatct      900

accgaagtcc aatgcaaagg cgggaatgtc tgcgtgcaag ctcaggatcg ctattacaat      960

tcctcatgca gcaagtgggc atgtgttccc tgcagggtcc gatccgggcc ggccgctgaa     1020

gctgccgcaa aagaggccgc tgcgaaggag gccgcggcta aggaggcggc agctaaagct     1080

gcagccgtgt caaccatctc atcattctct ccacctgggt accaagtctc tttctgcttg     1140

gtgatggtac tcctttttgc agtggacaca ggactatatt tctctgtgaa gacaaacatt     1200

tga                                                                   1203


<210>  12
<211>  400
<212>  PRT
<213>  Artificial

<220>
<223>  IL-12p40-RG polypeptide

<400>  12

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly 
                325                 330                 335     


Pro Ala Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
            340                 345                 350         


Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala Val Ser Thr Ile Ser Ser 
        355                 360                 365             


Phe Ser Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu 
    370                 375                 380                 


Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile 
385                 390                 395                 400 


<210>  13
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  14

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Ala Ala 
            20                  


<210>  15
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  15

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  16

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  17
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  residues 1-5 can be repeated 1-3 times

<400>  17

Glu Ala Ala Ala Lys 
1               5   


<210>  18
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  18

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  19
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  residues 1-5 can be repeated 1, 2, or 4 times

<400>  19

Gly Gly Gly Gly Ser 
1               5   


<210>  20
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  20

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  21
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  21

Pro Ala Pro Ala Pro 
1               5   


<210>  22
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  peptide linker

<400>  22

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  23
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  23
ggcggtcgac gagctcatgt gtcctcagaa gctaaccatc                             40


<210>  24
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  24
ccgcgttaac ctaggatcgg accctgcagg gaacac                                 36


<210>  25
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  25
ggcggtcgac atggtcagcg ttccaacagc ctc                                    33


<210>  26
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  26
cgcgggcgcg cctcaggcgg agctcagata gccc                                   34


<210>  27
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  27
ggcggtcgac gagctcatgt gtcctcagaa gctaaccatc                             40


<210>  28
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  28
ccgcggccgg cccggatcgg accctgcagg gaacac                                 36


<210>  29
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  29
ggcggtcgac gagctcatgt gtcctcagaa gctaaccatc                             40


<210>  30
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  30
gcgcgttaac tcaaatgttt gtcttcacag ag                                     32


<210>  31
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  31
ggcggtcgac atggtcagcg ttccaacagc ctc                                    33


<210>  32
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  32
cgcgggcgcg cctcaggcgg agctcagata gccc                                   34


<210>  33
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  33
ggccggccgg ccgctgaagc tgccgcaaaa gaggccgctg cgaaggaggc cgcggctaag       60


<210>  34
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  34
gcgcgttaac tcaaatgttt gtcttcacag ag                                     32


<210>  35
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  35
ggcggtcgac gagctcatgt gtcctcagaa gctaaccatc                             40


<210>  36
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  36
gcgcgttaac tcaaatgttt gtcttcacag ag                                     32


<210>  37
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  37
ggcggtcgac atggtcagcg ttccaacagc ctc                                    33


<210>  38
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  oligonucleotide primer

<400>  38
cgcgggcgcg cctcaggcgg agctcagata gccc                                   34


<210>  39
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  membrane anchoring polypeptide

<400>  39

Ser Phe Ser Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val 
1               5                   10                  15      


Leu Leu Phe Ala 
            20  


<210>  40
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  membrane anchoring polypeptide

<400>  40

Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met 
1               5                   10                  15      


Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr 
            20                  25                  30          


Asn Ile 
        


<210>  41
<211>  47
<212>  PRT
<213>  Artificial

<220>
<223>  membrane anchoring polypeptide

<400>  41

Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Arg Ala Gly Thr 
1               5                   10                  15      


Thr Asp Ala Ala His Pro Gly Pro Ser Val Val Pro Ala Leu Leu Pro 
            20                  25                  30          


Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Thr Ala Thr Ala Pro 
        35                  40                  45          


<210>  42
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  membrane anchoring polypeptide

<400>  42

Thr Thr Cys Ile Pro Ser Ser Gly His Ser Arg His Arg Tyr Ala Leu 
1               5                   10                  15      


Ile Pro Ile Pro Leu Ala Val Ile Thr Thr Cys Ile Val Leu Tyr Met 
            20                  25                  30          


Asn Gly Ile Leu Lys Cys Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
        35                  40                  45              


<210>  43
<211>  37
<212>  PRT
<213>  Artificial

<220>
<223>  membrane anchoring polypeptide

<400>  43

Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser 
1               5                   10                  15      


Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr 
            20                  25                  30          


Met Gly Leu Leu Thr 
        35          


<210>  44
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  membrane anchoring polypeptide

<400>  44

Tyr Thr Val Ser Asn Met Ala Thr Ile Ala Val Val Val Asp Leu Gly 
1               5                   10                  15      


Ala Val Ala Ile Ile Gly Ala Val Val Ala Phe Val Met Asn Arg Arg 
            20                  25                  30          


<210>  45
<211>  77
<212>  PRT
<213>  Artificial

<220>
<223>  membrane anchoring polypeptide

<400>  45

Leu Gln Cys Tyr Asn Cys Pro Asn Pro Thr Ala Asp Cys Lys Thr Ala 
1               5                   10                  15      


Val Asn Cys Ser Ser Asp Phe Asp Ala Cys Leu Ile Thr Lys Ala Gly 
            20                  25                  30          


Leu Gln Val Tyr Asn Lys Cys Trp Lys Phe Glu His Cys Asn Phe Asn 
        35                  40                  45              


Asp Val Thr Thr Arg Leu Arg Glu Asn Glu Leu Thr Tyr Tyr Cys Cys 
    50                  55                  60                  


Lys Lys Asp Leu Cys Asn Phe Asn Glu Gln Leu Glu Asn 
65                  70                  75          


<210>  46
<211>  221
<212>  PRT
<213>  Bos taurus

<400>  46

Met Cys Pro Leu Arg Ser Leu Leu Leu Ile Ser Thr Leu Val Leu Leu 
1               5                   10                  15      


His His Leu Pro His Leu Ser Leu Gly Arg Ser Leu Pro Thr Thr Thr 
            20                  25                  30          


Ala Ser Pro Gly Arg Ser Cys Leu Asp Tyr Ser Gln Asn Leu Leu Arg 
        35                  40                  45              


Ala Val Ser Asn Thr Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
    50                  55                  60                  


Ser Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
65                  70                  75                  80  


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Ala Thr Asn Glu 
                85                  90                  95      


Ser Cys Leu Ala Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly His Cys 
            100                 105                 110         


Leu Ala Ser Gly Lys Thr Ser Phe Met Thr Thr Leu Cys Leu Arg Ser 
        115                 120                 125             


Ile Tyr Glu Asp Leu Lys Met Tyr His Val Glu Phe Gln Ala Met Asn 
    130                 135                 140                 


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
145                 150                 155                 160 


Met Leu Ala Ala Ile Ala Glu Leu Met Gln Ala Leu Asn Phe Asp Ser 
                165                 170                 175     


Glu Thr Val Pro Gln Lys Pro Ser Leu Lys Glu Leu Asp Phe Tyr Lys 
            180                 185                 190         


Thr Lys Val Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
        195                 200                 205             


Val Thr Ile Asp Arg Met Met Ser Tyr Leu Ser Ser Ser 
    210                 215                 220     


<210>  47
<211>  221
<212>  PRT
<213>  Ovis aries

<400>  47

Met Cys Pro Leu Arg Ser Leu Leu Leu Ile Ser Thr Leu Val Leu Leu 
1               5                   10                  15      


His His Leu Pro His Leu Ser Leu Gly Arg Ser Leu Pro Thr Thr Thr 
            20                  25                  30          


Ala Gly Pro Gly Thr Ser Cys Leu Asp Tyr Ser Gln Asn Leu Leu Arg 
        35                  40                  45              


Ala Val Ser Asn Thr Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
    50                  55                  60                  


Ser Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
65                  70                  75                  80  


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Ala Thr Asn Glu 
                85                  90                  95      


Ser Cys Leu Ala Ser Arg Glu Thr Ser Leu Ile Thr Asn Gly His Cys 
            100                 105                 110         


Leu Ser Ser Gly Lys Thr Ser Phe Met Thr Thr Leu Cys Leu Arg Ser 
        115                 120                 125             


Ile Tyr Lys Asp Leu Lys Met Tyr His Met Glu Phe Gln Ala Met Asn 
    130                 135                 140                 


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Val Phe Leu Asp Gln Asn 
145                 150                 155                 160 


Met Leu Ala Ala Ile Ala Glu Leu Met Gln Ala Leu Asn Phe Asp Ser 
                165                 170                 175     


Glu Thr Val Pro Gln Lys Pro Ser Leu Glu Glu Leu Asp Phe Tyr Lys 
            180                 185                 190         


Thr Lys Val Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
        195                 200                 205             


Val Thr Ile Asp Arg Met Met Ser Tyr Leu Ser Ser Ser 
    210                 215                 220     


<210>  48
<211>  256
<212>  PRT
<213>  Sus scrofa

<400>  48

Met Cys Ser Pro Gly Phe Gly Leu Gln Thr Ser Asp Leu Thr Cys Asp 
1               5                   10                  15      


Val His Pro Ser Ala Ser Ser Arg Arg Leu Ala Val Thr Ala Ala Pro 
            20                  25                  30          


Leu Ser Met Cys Pro Leu Arg Asn Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asn His Leu Asp His Leu Ser Leu Gly Arg Ser Leu Pro Ala 
    50                  55                  60                  


Thr Thr Ala Gly Pro Gly Met Phe Lys Cys Leu Asn His Ser Gln Asn 
65                  70                  75                  80  


Leu Leu Lys Ala Val Ser Asn Thr Leu Gln Lys Ala Lys Gln Thr Leu 
                85                  90                  95      


Glu Phe Tyr Ser Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr 
            100                 105                 110         


Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Ala 
        115                 120                 125             


Thr Asn Glu Ser Cys Leu Ala Ala Arg Glu Thr Ser Leu Ile Thr Asn 
    130                 135                 140                 


Gly Asn Cys Leu Thr Ser Gly Lys Thr Ser Phe Met Thr Thr Leu Cys 
145                 150                 155                 160 


Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr His Val Glu Phe Gln 
                165                 170                 175     


Ala Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu 
            180                 185                 190         


Asp Gln Asn Met Leu Thr Ala Ile Thr Glu Leu Met Gln Ala Leu Asn 
        195                 200                 205             


Phe Asn Ser Glu Thr Val Pro Gln Lys Pro Ser Leu Glu Glu Leu Asp 
    210                 215                 220                 


Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg 
225                 230                 235                 240 


Ile Arg Ala Val Thr Ile Asp Arg Met Met Ser Tyr Leu Asn Ser Ser 
                245                 250                 255     


<210>  49
<211>  222
<212>  PRT
<213>  Felis catus

<400>  49

Met Cys Pro Pro Arg Gly Leu Leu Leu Val Thr Ile Leu Val Leu Leu 
1               5                   10                  15      


Asn His Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Thr Pro Thr 
            20                  25                  30          


Pro Ser Pro Gly Met Phe Gln Cys Leu Asn His Ser Gln Thr Leu Leu 
        35                  40                  45              


Arg Ala Ile Ser Asn Thr Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe 
    50                  55                  60                  


Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp 
65                  70                  75                  80  


Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Met Asn 
                85                  90                  95      


Glu Ser Cys Leu Ala Ser Arg Glu Ile Ser Leu Ile Thr Asn Gly Ser 
            100                 105                 110         


Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Thr Thr Leu Cys Leu Ser 
        115                 120                 125             


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Ala Met 
    130                 135                 140                 


Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln 
145                 150                 155                 160 


Asn Met Leu Thr Ala Ile Asp Glu Leu Leu Gln Ala Leu Asn Val Asn 
                165                 170                 175     


Ser Val Thr Val Pro Gln Asn Ser Ser Leu Glu Glu Pro Asp Phe Tyr 
            180                 185                 190         


Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg 
        195                 200                 205             


Ala Val Thr Ile Asn Arg Met Met Ser Tyr Leu Asn Ser Ser 
    210                 215                 220         


<210>  50
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  51
<211>  253
<212>  PRT
<213>  Papio anubis

<400>  51

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Thr 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp Tyr Leu Ser Leu Ala Arg Asn Leu Ser Val Ala Thr Pro 
    50                  55                  60                  


Gly Pro Glu Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Lys 
65                  70                  75                  80  


Ala Ala Ser Asn Thr Leu Gln Lys Ala Arg Gln Ile Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Ile Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Val Ile Thr Lys Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Arg Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Gln Ile Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Ile Leu Gly Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Arg Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  52
<211>  328
<212>  PRT
<213>  Macaca mulatta

<400>  52

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Met Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Gly Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Ala 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Val Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asn Pro Gln Gly Val Thr Cys Gly Ala Val Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Arg Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Ile Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Ile Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Phe Ser Val Gln Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  53
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  53

Met Val Ser Val Pro Thr Ala Ser Pro Ser Ala Ser Ser Ser Ser Ser 
1               5                   10                  15      


Gln Cys Arg Ser Ser Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala 
            20                  25                  30          


Thr Leu Ala Leu Leu Asn His Leu Ser Leu Ala Arg Val Ile Pro Val 
        35                  40                  45              


Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr 
    50                  55                  60                  


Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser 
65                  70                  75                  80  


Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr 
                85                  90                  95      


Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser 
            100                 105                 110         


Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu 
        115                 120                 125             


Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile 
    130                 135                 140                 


Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala 
145                 150                 155                 160 


Ala Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met 
                165                 170                 175     


Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu 
            180                 185                 190         


Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val 
        195                 200                 205             


Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val 
    210                 215                 220                 


Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 
225                 230                 235     


<210>  54
<211>  215
<212>  PRT
<213>  Rattus norvegicus

<400>  54

Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asn His Leu Thr Ser Ala Arg Val Ile Pro Val Ser Gly Pro Ala Lys 
            20                  25                  30          


Cys Leu Asn Gln Ser Gln Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
        35                  40                  45              


Arg Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Gly Asp 
    50                  55                  60                  


Ile Asp His Glu Asp Ile Thr Arg Asp Lys Thr Ser Thr Leu Glu Ala 
65                  70                  75                  80  


Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Lys 
                85                  90                  95      


Glu Thr Ser Ser Ile Ile Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
            100                 105                 110         


Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
        115                 120                 125             


Met Tyr Gln Ser Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Ser His 
    130                 135                 140                 


Asn His Gln Gln Ile Thr Leu Asp Arg Asn Met Leu Met Ala Ile Asp 
145                 150                 155                 160 


Glu Leu Met Arg Ser Leu Asn His Ser Gly Glu Thr Leu His Gln Lys 
                165                 170                 175     


Ala Pro Met Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
            180                 185                 190         


Ile Leu Leu His Ala Phe Ser Thr Arg Val Met Thr Ile Asn Arg Val 
        195                 200                 205             


Met Asn Tyr Leu Ser Ser Ser 
    210                 215 


<210>  55
<211>  139
<212>  PRT
<213>  Artificial

<220>
<223>  consensus IL-12p35 polypeptide sequence

<400>  55

Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu 
1               5                   10                  15      


Glu Leu Asn Glu Ser Cys Leu Ala Ser Arg Glu Thr Ser Ile Thr Asn 
            20                  25                  30          


Gly Ser Cys Leu Ala Ser Lys Thr Ser Phe Met Met Thr Leu Cys Leu 
        35                  40                  45              


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Gln Ala Met 
    50                  55                  60                  


Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln 
65                  70                  75                  80  


Asn Met Leu Ala Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
                85                  90                  95      


Glu Thr Val Pro Gln Lys Ser Leu Glu Glu Asp Phe Tyr Lys Thr Lys 
            100                 105                 110         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        115                 120                 125             


Ile Asp Arg Met Met Ser Tyr Leu Ser Ser Ser 
    130                 135                 


<210>  56
<211>  250
<212>  PRT
<213>  Bos taurus

<400>  56

Met His Pro Gln Gln Leu Val Val Ser Trp Phe Ser Leu Val Leu Leu 
1               5                   10                  15      


Ala Ser Pro Ile Val Ala Met Trp Glu Leu Glu Lys Asn Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Thr Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Ala 
                85                  90                  95      


Leu Ser Arg Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Ala Lys Ser Phe 
        115                 120                 125             


Leu Lys Cys Glu Ala Lys Asp Tyr Ser Gly His Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Ala Ile Ser Thr Asp Leu Lys Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Arg Gly Val Thr Cys Gly Ala Ala Leu Leu Ser 
                165                 170                 175     


Ala Glu Lys Val Ser Leu Glu His Arg Glu Tyr Asn Lys Tyr Thr Val 
            180                 185                 190         


Glu Cys Gln Glu Gly Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Leu 
        195                 200                 205             


Ile Glu Val Val Val Glu Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
    210                 215                 220                 


Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
225                 230                 235                 240 


Asn Leu Gln Leu Arg Pro Leu Lys Asn Ser 
                245                 250 


<210>  57
<211>  327
<212>  PRT
<213>  Ovis aries

<400>  57

Met His Pro Gln Gln Leu Val Val Ser Trp Phe Ser Leu Val Leu Leu 
1               5                   10                  15      


Ala Ser Pro Ile Val Ala Ile Trp Glu Leu Glu Lys Asn Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asn Ala Pro Gly Glu Thr Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser Arg Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Ala Lys Ser Phe 
        115                 120                 125             


Leu Lys Cys Glu Ala Lys Asp Tyr Ser Gly His Phe Thr Cys Ser Trp 
    130                 135                 140                 


Leu Thr Ala Ile Ser Thr Asn Leu Lys Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Arg Gly Val Thr Cys Gly Ala Ala Ser Leu Ser 
                165                 170                 175     


Ala Glu Lys Val Ser Met Asp His Arg Glu Tyr Asn Lys Tyr Thr Val 
            180                 185                 190         


Glu Cys Gln Glu Gly Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro 
        195                 200                 205             


Ile Glu Val Val Met Glu Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
    210                 215                 220                 


Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
225                 230                 235                 240 


Asn Leu Gln Leu Arg Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser 
                245                 250                 255     


Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
            260                 265                 270         


Thr Phe Cys Val Gln Val Gln Gly Lys Asn Lys Arg Glu Lys Lys Leu 
        275                 280                 285             


Phe Thr Asp Gln Thr Ser Ala Lys Val Thr Cys His Lys Asp Ala Asn 
    290                 295                 300                 


Ile Arg Val Gln Ala Arg Asp Arg Tyr Tyr Ser Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Ser Cys Ser 
                325         


<210>  58
<211>  324
<212>  PRT
<213>  Sus scrofa

<400>  58

Met His Leu Gln Gln Leu Val Val Ser Trp Phe Ser Leu Val Trp Leu 
1               5                   10                  15      


Ala Ser Pro Ile Val Ala Ile Trp Glu Leu Glu Lys Asn Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asn Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asn Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Thr Gly Lys Thr Leu Thr Ile His Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys Arg Lys Gly Gly Ala Val 
                85                  90                  95      


Leu Ser Gln Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Ser Phe 
        115                 120                 125             


Leu Lys Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Ala Ile Ser Thr Asp Leu Lys Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Thr Asp Pro Arg Gly Val Thr Cys Gly Thr Ala Thr Leu Ser 
                165                 170                 175     


Glu Asp Leu Gly Glu Tyr Lys Lys Tyr Arg Val Glu Cys Gln Glu Gly 
            180                 185                 190         


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Val Leu 
        195                 200                 205             


Glu Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
    210                 215                 220                 


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Asn 
225                 230                 235                 240 


Pro Leu Lys Asn Ser Arg His Val Glu Ile Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Met Phe Gly Val Gln 
            260                 265                 270         


Val Gln Gly Lys Asn Lys Arg Glu Lys Lys Asp Lys Leu Phe Thr Asp 
        275                 280                 285             


Gln Ile Ser Ala Lys Val Thr Cys His Lys Asp Ala Asn Ile Arg Val 
    290                 295                 300                 


Gln Ala Arg Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
305                 310                 315                 320 


Val Ser Cys Asn 
                


<210>  59
<211>  329
<212>  PRT
<213>  Felis catus

<400>  59

Met His Pro Gln Gln Leu Val Ile Ala Trp Leu Ser Leu Val Leu Leu 
1               5                   10                  15      


Ala Pro Pro Leu Met Ala Ile Trp Glu Leu Glu Lys Asn Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp His Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asn Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Ala Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Phe Leu Leu Ile His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Arg Glu Gln Lys Glu Ser Lys Asn Lys Ile Phe 
        115                 120                 125             


Leu Lys Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Ala Ile Ser Thr Asp Leu Lys Phe Thr Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Glu Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Lys Val Arg Val Asp Asn Arg Asp Tyr Lys Lys Tyr Thr Val 
            180                 185                 190         


Glu Cys Gln Glu Gly Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro 
        195                 200                 205             


Ile Glu Val Val Val Asp Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr 
    210                 215                 220                 


Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
225                 230                 235                 240 


Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg His Val Glu Val Ser 
                245                 250                 255     


Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
            260                 265                 270         


Thr Phe Gly Val Gln Val Gln Gly Lys Asn Asn Arg Glu Lys Lys Asp 
        275                 280                 285             


Arg Leu Ser Val Asp Lys Thr Ser Ala Lys Val Val Cys His Lys Asp 
    290                 295                 300                 


Ala Lys Ile Arg Val Gln Ala Arg Asp Arg Tyr Tyr Ser Ser Ser Trp 
305                 310                 315                 320 


Ser Asn Trp Ala Ser Val Ser Cys Ser 
                325                 


<210>  60
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  61
<211>  328
<212>  PRT
<213>  Macaca mulatta

<400>  61

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Met Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Gly Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Ala 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Val Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asn Pro Gln Gly Val Thr Cys Gly Ala Val Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Arg Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Ile Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Ile Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Phe Ser Val Gln Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  62
<211>  328
<212>  PRT
<213>  Papio anubis

<400>  62

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Met Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Gly Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Ala 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Val Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asn Pro Gln Gly Val Thr Cys Gly Ala Val Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Arg Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Ala Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Ile Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Ile Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Phe Ser Val Gln Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  63
<211>  335
<212>  PRT
<213>  Mus musculus

<400>  63

Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210>  64
<211>  335
<212>  PRT
<213>  Rattus norvegicus

<400>  64

Met Cys His Gln Lys Leu Thr Phe Ser Trp Phe Ala Met Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Arg Pro Asp Ala Pro Gly Glu Thr Val Thr Leu 
        35                  40                  45              


Thr Cys Asp Ser Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg Arg Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Arg 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Arg Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val His 
    130                 135                 140                 


Arg Asn Thr Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Glu Ser Arg Ala Val Thr Cys Gly Arg Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asn Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ala Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Val Val Glu Ala Gln Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Val Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Thr Lys Glu Thr Glu Glu Glu Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Ala Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Ala Asn Ile Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Thr Cys Val Pro Cys Arg Gly Arg Ser 
                325                 330                 335 


<210>  65
<211>  319
<212>  PRT
<213>  Artificial

<220>
<223>  consensus IL-12p40 polypeptide sequence

<400>  65

Met Cys Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Leu Leu Ala 
1               5                   10                  15      


Ser Pro Leu Met Ala Ile Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Ser Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Leu Ser 
                85                  90                  95      


His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr 
            100                 105                 110         


Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Lys 
        115                 120                 125             


Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr 
    130                 135                 140                 


Ile Ser Thr Asp Leu Lys Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Arg Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Leu Asp Asn Arg Asp Tyr Lys Tyr Ser Val Glu Cys Gln Glu Asp 
            180                 185                 190         


Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Val Val 
        195                 200                 205             


Glu Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
    210                 215                 220                 


Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
225                 230                 235                 240 


Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
            260                 265                 270         


Val Gln Gly Lys Lys Arg Glu Lys Lys Asp Arg Leu Phe Thr Asp Lys 
        275                 280                 285             


Thr Ser Ala Val Cys Arg Lys Ala Asn Ile Val Gln Ala Gln Asp Arg 
    290                 295                 300                 


Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser 
305                 310                 315                 


