                         SEQUENCE LISTING

<110>  Francesco Luppino
 
<120>  GROWTH FACTOR RESTORATION

<130>  51518-003WO2

<150>  US 62/938,879
<151>  2019-11-21

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
atgcctacac tgctgcgggt ttacatcgac ggccctcacg gcatgggcaa gaccaccaca       60

acacagctgc tcgtggccct gggctccaga gacgacattg tgtacgtgcc tgagcccatg      120

acctactggc gggtcctggg agcctctgaa accatcgcca atatctacac cactcagcac      180

agactggatc agggcgagat cagcgctggc gacgccgccg tggtgatgac cagcgcccag      240

atcaccatgg gcatgcccta cgccgtcacc gacgccgtgc tggctcctca tattggcggc      300

gaagccggta gcagccacgc ccctcctcca gctctgaccc ttatcttcga ccggcacccc      360

atcgccgctc tgctgtgcta ccccgctgct agatacctga tgggctccat gacacctcag      420

gccgtgctgg ccttcgtggc cctgatcccc cccaccctgc ctggcacaaa catcgtgctg      480

ggcgccctgc cagaagatag acacatcgat agactggcca agcggcagcg gccaggcgag      540

agactggatc tggccatgct ggctgctatc cgcagagtgt atggcctgct ggccaatacc      600

gtgagatacc tgcagggcgg cggaagctgg agagaggact ggggccagct gagcgggacc      660

gccgtgcccc cccagggcgc cgagcctcaa agcaacgccg gccctagacc ccacatcggc      720

gatacgctgt ttaccctgtt cagagcccct gagctgctgg cccctaacgg cgacctgtac      780

aacgtgtttg cctgggccct cgacgtgctg gctaaaagac tgaggcctat gcacgtgttc      840

atcctggact acgaccagtc tcctgccgga tgtagagatg cactgctgca actgacaagc      900

ggcatgatcc agacccacgt gaccacacct ggatctatcc ctaccatctg cgacctggcc      960

agaacattcg cccgggaaat gggagaggcc aactaa                                996


<210>  2
<211>  1554
<212>  DNA
<213>  Human alphaherpesvirus 1

<400>  2
atggcctcta gaatcctgtg gcatgagatg tggcacgagg gcctggaaga ggctagtaga       60

ctgtacttcg gcgagcggaa cgtgaagggc atgttcgagg tcctggaacc cctgcacgcc      120

atgatggaaa gaggccctca gaccctgaag gaaacaagct tcaaccaggc ctatggccgc      180

gatctgatgg aagcccagga gtggtgccgg aagtacatga aaagcgggaa tgtgaaggac      240

ctgctgcaag cctgggacct gtactaccac gtgttcagac ggatcagcaa gctggaatac      300

agcggaggag gaagcctgga aggagttcag gtggaaacca tctctcctgg cgatggcaga      360

acattcccca aaagaggaca gacctgtgtg gtgcactaca ccggcatgct ggaagatgga      420

aagaaattcg acagcagcag agaccggaac aagcctttca agttcatgct gggcaaacag      480

gaggtgatca gaggctggga ggaaggcgtg gcccaaatga gcgtgggcca gcgggccaaa      540

ctgacaattt ctcctgacta cgcctacggc gctaccggac accctggcat catccccccc      600

cacgccaccc tggtctttga tgtggagctg ctgaagctgg agagcggagg cggcggctct      660

ggaggcggtg gcagcggcgg cggcggttcc ggcgtggacg gcttcggcga cgtgggcgcc      720

ctggaaagcc tcagaggcaa cgccgatctg gcttacattc tgagcatgga gccttgtggc      780

cactgcctga tcatcaacaa cgtgaacttc tgcagagaga gcggactgcg caccagaacc      840

ggcagcaaca tcgactgcga gaagctgcgg agaagattca gctctctgca cttcatggtc      900

gaggtgaaag gagatctcac cgccaagaag atggtgctgg ccctgctcga actggcccag      960

caggaccacg gcgccctgga ctgctgcgtg gtggtcatcc tgagccatgg ctgtcaggct     1020

agccacctgc agttccctgg agcagtgtac ggcaccgacg gttgccctgt gtccgtggaa     1080

aagatcgtga acatcttcaa cggcacatcc tgccccagcc tgggcggcaa gcccaagctg     1140

ttcttcatcc aggcttgtgg cggcgaacag aaggaccacg gcttcgaggt ggccagcaca     1200

agccccgagg acgagtctcc aggctctaat cctgagccag acgccacccc ttttcaggag     1260

ggcctgagaa cttttgacca gctggatgcc atctccagcc tgcctacacc tagcgatatc     1320

ttcgtgtcat atagcacctt tccaggattc gtgagctggc gggaccctaa gagcggctcc     1380

tggtacgtgg agacactgga cgatatcttt gagcagtggg cccacagcga ggaccttcaa     1440

tctctgctgc tgcgggtggc taatgccgtg tccgttaagg gcatctacaa gcagatgcct     1500

ggctgcttca acttcttgag aaagaagctg tttttcaaga ccagcgccag ctaa           1554


<210>  3
<211>  1998
<212>  DNA
<213>  Homo sapiens

<400>  3
gggaggcggc gatgcgcacg gccggagaga cgcggaggag gagacatgag ccggcgggcg       60

cccagacgga gcggccgtga cgctttcgcg ctgcagccgc gcgccccgac cccggagcgc      120

tgacccctgg ccccacgcag ctccgcgccc gggccggaga gcgcaactcg gcttccagac      180

ccgccgcgca tgctgtcccc ggactgagcc gggcagccag cctcccacgg acgcccggac      240

ggccggccgg ccagcagtga gcgagcttcc ccgcaccggc caggcgcctc ctgcacagcg      300

gctgccgccc cgcagcccct gcgccagccc ggagggcgca gcgctcggga ggagccgcgc      360

ggggcgctga tgccgcaggg cgcgccgcgg agcgccccgg agcagcagag tctgcagcag      420

cagcagccgg cgaggaggga gcagcagcag cggcggcggc ggcggcggcg gcggcggagg      480

cgcccggtcc cggccgcgcg gagcggacat gtgcaggctg ggctaggagc cgccgcctcc      540

ctcccgccca gcgatgtatt cagcgccctc cgcctgcact tgcctgtgtt tacacttcct      600

gctgctgtgc ttccaggtac aggtgctggt tgccgaggag aacgtggact tccgcatcca      660

cgtggagaac cagacgcggg ctcgggacga tgtgagccgt aagcagctgc ggctgtacca      720

gctctacagc cggaccagtg ggaaacacat ccaggtcctg ggccgcagga tcagtgcccg      780

cggcgaggat ggggacaagt atgcccagct cctagtggag acagacacct tcggtagtca      840

agtccggatc aagggcaagg agacggaatt ctacctgtgc atgaaccgca aaggcaagct      900

cgtggggaag cccgatggca ccagcaagga gtgtgtgttc atcgagaagg ttctggagaa      960

caactacacg gccctgatgt cggctaagta ctccggctgg tacgtgggct tcaccaagaa     1020

ggggcggccg cggaagggcc ccaagacccg ggagaaccag caggacgtgc atttcatgaa     1080

gcgctacccc aaggggcagc cggagcttca gaagcccttc aagtacacga cggtgaccaa     1140

gaggtcccgt cggatccggc ccacacaccc tgcctaggcc accccgccgc ggcccctcag     1200

gtcgccctgg ccacactcac actcccagaa aactgcatca gaggaatatt tttacatgaa     1260

aaataaggaa gaagctctat ttttgtacat tgtgtttaaa agaagacaaa aactgaacca     1320

aaactcttgg ggggaggggt gataaggatt ttattgttga cttgaaaccc ccgatgacaa     1380

aagactcacg caaagggact gtagtcaacc cacaggtgct tgtctctctc taggaacaga     1440

caactctaaa ctcgtcccca gaggaggact tgaatgagga aaccaacact ttgagaaacc     1500

aaagtccttt ttcccaaagg ttctgaaagg aaaaaaaaaa aaaacaaaaa aaaagaaaaa     1560

caaagagaaa gtagtactcc gcccaccaac aaactccccc taactttccc aatcctctgt     1620

tcctgcccca aactccaaca aaaatcgctc tctggtttgc agtcatttat ttattgtccg     1680

ctgcaagctg ccccgagaca ccgcgcaggg aaggcgtgcc cctgggaatt ctccgcgcct     1740

cgacctcccg acgacagacg cctcgtccaa tcatggtgac cctgccttgc tcgcagttct     1800

ggaggatgct gctatcgacc ttccgtgact cacgtgacct agtacaccaa tgataaggga     1860

atattttaaa accagctata ttatatatat tatatatata taagctattt atttcacctc     1920

tctgtatatt gcagtttcat gaaccaagta ttactgcctc aacaattaaa aacaacagac     1980

aaattattta aaaaacca                                                   1998


<210>  4
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Tyr Ser Ala Pro Ser Ala Cys Thr Cys Leu Cys Leu His Phe Leu 
1               5                   10                  15      


Leu Leu Cys Phe Gln Val Gln Val Leu Val Ala Glu Glu Asn Val Asp 
            20                  25                  30          


Phe Arg Ile His Val Glu Asn Gln Thr Arg Ala Arg Asp Asp Val Ser 
        35                  40                  45              


Arg Lys Gln Leu Arg Leu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Ile Gln Val Leu Gly Arg Arg Ile Ser Ala Arg Gly Glu Asp Gly 
65                  70                  75                  80  


Asp Lys Tyr Ala Gln Leu Leu Val Glu Thr Asp Thr Phe Gly Ser Gln 
                85                  90                  95      


Val Arg Ile Lys Gly Lys Glu Thr Glu Phe Tyr Leu Cys Met Asn Arg 
            100                 105                 110         


Lys Gly Lys Leu Val Gly Lys Pro Asp Gly Thr Ser Lys Glu Cys Val 
        115                 120                 125             


Phe Ile Glu Lys Val Leu Glu Asn Asn Tyr Thr Ala Leu Met Ser Ala 
    130                 135                 140                 


Lys Tyr Ser Gly Trp Tyr Val Gly Phe Thr Lys Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Pro Lys Thr Arg Glu Asn Gln Gln Asp Val His Phe Met Lys 
                165                 170                 175     


Arg Tyr Pro Lys Gly Gln Pro Glu Leu Gln Lys Pro Phe Lys Tyr Thr 
            180                 185                 190         


Thr Val Thr Lys Arg Ser Arg Arg Ile Arg Pro Thr His Pro Ala 
        195                 200                 205         


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Ser Trp Ser His Pro Gln Phe Glu Lys 
1               5                   


<210>  6
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
1               5                   10                  15      


Ile Phe Pro Pro Lys Pro Lys Asp Val 
            20                  25  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Val 
            20  


<210>  8
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  8

Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Val 
            20              


<210>  9
<211>  12
<212>  PRT
<213>  Cricetulus griseus

<400>  9

Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
1               5                   10          


<210>  10
<211>  7
<212>  PRT
<213>  Oncorhynchus mykiss

<400>  10

Pro Pro Lys Pro Lys Asp Val 
1               5           


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Glu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Val 
            20              


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala 
            20      


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  14
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  15
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  16
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser 
            20              


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Leu Ala Leu Ala 
1               5                   10                  15      


<210>  18
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  20
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  21
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  22
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu Val 
1               5                   10                  


<210>  23
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  24
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe 
            20                  25  


<210>  25
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Tyr Ser Ala Pro Ser Ala Cys Thr Cys Leu Cys Leu His Phe Leu 
1               5                   10                  15      


Leu Leu Cys Phe Gln Val Gln Val Leu Val Ala 
            20                  25          


