                         SEQUENCE LISTING

<110>  Spark Therapeutics
 
<120>  SECRETABLE PROTEIN INDUCED IMMUNE TOLERIZATION AND TREATMENT OF 
       AUTOIMMUNE, ALLERGIC AND OTHER DISEASES AND DISORDERS

<130>  SPK168PCT

<150>  62/937,581
<151>  2019-11-19

<160>  492   

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spk1 VP1 capsid

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  2
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spk2 VP1 capsid

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  3
<211>  1672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG Promoter Sequence

<400>  3
atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac       60

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      120

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      180

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      240

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      300

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      360

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      420

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      480

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      540

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      600

gggcggggag tcgctgcgac gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg      660

ccgcccgccc cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc      720

ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct      780

gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg      840

tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg      900

tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc      960

ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg     1020

gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc     1080

cctgcacccc cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac     1140

ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg     1200

cggggcgggg ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag     1260

cgccggcggc tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga     1320

gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg     1380

ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg     1440

cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg     1500

ctgtccgcgg ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg     1560

gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct     1620

acagctcctg ggcaacgtgc tggttattgt gctgtctcat cattttggca aa             1672


<210>  4
<211>  749
<212>  DNA
<213>  Mus musculus

<400>  4
atggcctgtt tgtggagctt ctcttggccc agctgcttcc tctcccttct cctcctcctt       60

ctcctccagt tgtcatgcag ctatgcagga caattcagag tgataggacc agggtatccc      120

atccgggctt tagttgggga tgaagcagag ctgccgtgcc gcatctctcc tgggaaaaat      180

gccacgggca tggaggtggg ttggtaccgt tctcccttct caagagtggt tcacctctac      240

cgaaatggca aggaccaaga tgcagagcaa gcacctgaat accggggacg cacagagctt      300

ctgaaagaga ctatcagtga gggaaaggtt acccttagga ttcagaacgt gagattctca      360

gatgaaggag gctacacctg cttcttcaga gaccactctt accaagaaga ggcagcaatg      420

gagttgaaag tggaagatcc cttctattgg gtcaaccccg gtgtgctgac tctcatcgca      480

cttgtgccta cgatcctcct gcaggtctct gtaggccttg tattcctctt cctgcagcac      540

agactgagag gaaaacttcg tgcagaagta gagaatctcc atcggacttt tgatcctcac      600

ttcctgaggg tgccctgctg gaagataaca ctgtttgtta ttgtgcctgt tcttggaccc      660

ctggttgcct tgatcctgtg ctacaactgg ctgcaccgaa gactggcagg acagtttctt      720

gaagagctaa gaaacccctt ttgaagatc                                        749


<210>  5
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Cys Leu Trp Ser Phe Ser Trp Pro Ser Cys Phe Leu Ser Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Leu Ser Cys Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Gly Tyr Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Glu Thr Ile Ser Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Gln Asn Val Arg Phe Ser Asp Glu Gly Gly Tyr Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Asn Pro Gly Val Leu Thr Leu Ile Ala 
145                 150                 155                 160 


Leu Val Pro Thr Ile Leu Leu Gln Val Ser Val Gly Leu Val Phe Leu 
                165                 170                 175     


Phe Leu Gln His Arg Leu Arg Gly Lys Leu Arg Ala Glu Val Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Leu Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  6
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  7
<211>  247
<212>  PRT
<213>  Macaca mulatta

<400>  7

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg Gln Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Arg Asp Gln Asp Gly Glu Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Ile Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Ala Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Val Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  8
<211>  245
<212>  PRT
<213>  Callithrix jacchus

<400>  8

Met Ala Ser Leu Ser Lys Pro Ser Leu Pro Ser Tyr Leu Cys Phe Leu 
1               5                   10                  15      


Leu Leu Leu Leu His Val Ser Ser Ser Tyr Gly Gly Gln Phe Arg Val 
            20                  25                  30          


Ile Gly Pro Ser His Pro Ile Gln Ala Leu Val Gly Asp Ala Ala Glu 
        35                  40                  45              


Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val 
    50                  55                  60                  


Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn 
65                  70                  75                  80  


Gly Lys Asp Gln Asp Gly Glu Gln Ala Pro Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Glu Leu Leu Lys Asp Asp Ile Gly Glu Gly Lys Val Thr Leu Lys Ile 
            100                 105                 110         


Arg Asn Val Arg Phe Pro Asp Glu Gly Gly Phe Thr Cys Phe Phe Arg 
        115                 120                 125             


Asp His Ser Tyr Gln Glu Glu Ala Ala Met Gln Leu Lys Val Glu Asp 
    130                 135                 140                 


Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu 
145                 150                 155                 160 


Pro Val Leu Phe Leu Gln Ile Thr Val Gly Leu Val Phe Leu Tyr Leu 
                165                 170                 175     


Gln His Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His 
            180                 185                 190         


Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr 
        195                 200                 205             


Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile 
    210                 215                 220                 


Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu Glu 
225                 230                 235                 240 


Leu Arg Asn Pro Phe 
                245 


<210>  9
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native leader + Mus musculus mini-MOG cDNA

<400>  9
atggcctgtt tgtggagctt ctcttggccc agctgcttcc tctcccttct cctcctcctt       60

ctcctccagt tgtcatgcag ctatgcagga caattcagag tgataggacc agggtatccc      120

atccgggctt tagttgggga tgaagcagag ctgccgtgcc gcatctctcc tgggaaaaat      180

gccacgggca tggaggtggg ttggtaccgt tctcccttct caagagtggt tcacctctac      240

cgaaatggca aggaccaaga tgcagagcaa gcacctgaat accggggacg cacagagctt      300

ctgaaagaga ctatcagtga gggaaaggtt acccttagga ttcagaacgt gagattctca      360

gatgaaggag gctacacctg cttcttcaga gaccactctt accaagaaga ggcagcaatg      420

gagttgaaag tggaagatcc cttctattgg gtcaaccccg gtgtgctgac ttga            474


<210>  10
<211>  446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human chymotrypsinogen B2 signal peptide + Mus musculus mini-MOG 
       cDNA

<400>  10
atggcctttc tgtggctgct gtcctgctgg gccctgctgg ggaccacctt tggcggacaa       60

ttcagagtga taggaccagg gtatcccatc cgggctttag ttggggatga agcagagctg      120

ccgtgccgca tctctcctgg gaaaaatgcc acgggcatgg aggtgggttg gtaccgttct      180

cccttctcaa gagtggttca cctctaccga aatggcaagg accaagatgc agagcaagca      240

cctgaatacc ggggacgcac agagcttctg aaagagacta tcagtgaggg aaaggttacc      300

cttaggattc agaacgtgag attctcagat gaaggaggct acacctgctt cttcagagac      360

cactcttacc aagaagaggc agcaatggag ttgaaagtgg aagatccctt ctattgggtc      420

aaccccggtg tgctgacttg aagatc                                           446


<210>  11
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC7 leader + Mus musculus mini-MOG cDNA

<400>  11
atggagtttg ggctgagctg ggttttcctc gttgctcttt ttagaggtgt ccagtgtgga       60

caattcagag tgataggacc agggtatccc atccgggctt tagttgggga tgaagcagag      120

ctgccgtgcc gcatctctcc tgggaaaaat gccacgggca tggaggtggg ttggtaccgt      180

tctcccttct caagagtggt tcacctctac cgaaatggca aggaccaaga tgcagagcaa      240

gcacctgaat accggggacg cacagagctt ctgaaagaga ctatcagtga gggaaaggtt      300

acccttagga ttcagaacgt gagattctca gatgaaggag gctacacctg cttcttcaga      360

gaccactctt accaagaaga ggcagcaatg gagttgaaag tggaagatcc cttctattgg      420

gtcaaccccg gtgtgctgac ttga                                             444


<210>  12
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gaussia leader + Mus musculus mini-MOG cDNA

<400>  12
atgggagtca aagttctgtt tgccctgatc tgcatcgctg tggccgaggc caagcccgga       60

caattcagag tgataggacc agggtatccc atccgggctt tagttgggga tgaagcagag      120

ctgccgtgcc gcatctctcc tgggaaaaat gccacgggca tggaggtggg ttggtaccgt      180

tctcccttct caagagtggt tcacctctac cgaaatggca aggaccaaga tgcagagcaa      240

gcacctgaat accggggacg cacagagctt ctgaaagaga ctatcagtga gggaaaggtt      300

acccttagga ttcagaacgt gagattctca gatgaaggag gctacacctg cttcttcaga      360

gaccactctt accaagaaga ggcagcaatg gagttgaaag tggaagatcc cttctattgg      420

gtcaaccccg gtgtgctgac ttga                                             444


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native mouse MOG leader sequence

<400>  13

Met Ala Cys Leu Trp Ser Phe Ser Trp Pro Ser Cys Phe Leu Ser Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Leu Ser Cys Ser Tyr Ala 
            20                  25                  


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC1 leader sequence

<400>  14

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC2 leader sequence

<400>  15

Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC3 leader sequence

<400>  16

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC4 leader sequence

<400>  17

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC5 leader sequence

<400>  18

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC6 leader sequence

<400>  19

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC7 leader sequence

<400>  20

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC8 leader sequence

<400>  21

Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      


Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC1 leader sequence

<400>  22

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys 
            20          


<210>  23
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC2 leader sequence

<400>  23

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human chymotrypsinogen B2 signal peptide

<400>  24

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gaussia leader sequence

<400>  25

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Lys Pro 
            


<210>  26
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Native mouse MOG leader sequence

<400>  26
atggcatgtt tatggtcatt ttcatggcca tcatgttttt tatcattatt attattatta       60

ttattacaat tatcatgttc atatgca                                           87


<210>  27
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC1 leader sequence

<400>  27
atggagttgg gactgagctg gattttcctt ttggctattt taaaaggtgt ccagtgt          57


<210>  28
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC2 leader sequence

<400>  28
atggaactgg ggctccgctg ggttttcctt gttgctattt tagaaggtgt ccagtgt          57


<210>  29
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC3 leader sequence

<400>  29
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtcc          57


<210>  30
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC4 leader sequence

<400>  30
atggactgga cctggaggat cctcttcttg gtggcagcag caacaggtgc ccactcg          57


<210>  31
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC5 leader sequence

<400>  31
atggactgga cctggaggtt cctctttgtg gtggcagcag ctacaggtgt ccagtcc          57


<210>  32
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC6 leader sequence

<400>  32
atggagtttg ggctgagctg gctttttctt gtggcgattc taaaaggtgt ccagtgt          57


<210>  33
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC7 leader sequence

<400>  33
atggagtttg ggctgagctg ggttttcctc gttgctcttt ttagaggtgt ccagtgt          57


<210>  34
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC8 leader sequence

<400>  34
atggacctcc tgcacaagaa catgaaacac ctgtggttct tcctcctcct ggtggcagct       60

cccagatggg tgctgtcc                                                     78


<210>  35
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC1 leader sequence

<400>  35
atggacatga gggtccctgc tcagctcctg gggctcctgc tgctctggct ctcaggtgcc       60

agatgt                                                                  66


<210>  36
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC2 leader sequence

<400>  36
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggcc                                                                  66


<210>  37
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human chymotrypsinogen B2 signal peptide

<400>  37
gcctttctgt ggctgctgtc ctgctgggcc ctgctgggga ccacctttgg c                51


<210>  38
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gaussia leader sequence

<400>  38
atgggagtca aagttctgtt tgccctgatc tgcatcgctg tggccgaggc caagccc          57


<210>  39
<211>  277
<212>  PRT
<213>  Mus musculus

<400>  39

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  40
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  40

Met Gly Asn His Ser Gly Lys Arg Glu Leu Ser Ala Glu Lys Ala Ser 
1               5                   10                  15      


Lys Asp Gly Glu Ile His Arg Gly Glu Ala Gly Lys Lys Arg Ser Val 
            20                  25                  30          


Gly Lys Leu Ser Gln Thr Ala Ser Glu Asp Ser Asp Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Ile Gln Asn Asn Gly Thr Ser Ala Glu Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys His Thr Ala Asp Pro Lys Asn Asn Trp Gln Gly Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Asn Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Pro Thr Ala Ala Ser 
        115                 120                 125             


Gly Gly Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg Ser 
    130                 135                 140                 


Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe 
145                 150                 155                 160 


Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe 
                165                 170                 175     


Phe Ser Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Ser 
            180                 185                 190         


Ser Glu Pro 
        195 


<210>  41
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                 200                 205             


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                 215                 220                 


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                 230                 235                 240 


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                 250                 255     


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                 265                 270         


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                 280                 285             


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
    290                 295                 300                 


<210>  42
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 
    130                 135                 140                 


Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 
145                 150                 155                 160 


Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
                165                 170                 175     


Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 
            180                 185                 190         


Pro Met Ala Arg Arg 
        195         


<210>  43
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly 
    130                 135                 140                 


Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val 
145                 150                 155                 160 


Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp 
                165                 170                 175     


Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
            180                 185     


<210>  44
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu 
            100                 105                 110         


Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr 
        115                 120                 125             


Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly 
    130                 135                 140                 


Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg 
145                 150                 155                 160 


Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
                165                 170     


<210>  45
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg 
            100                 105                 110         


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
        115                 120                 125             


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
    130                 135                 140                 


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
145                 150                 155                 160 


<210>  46
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Val Ser Ser Glu Glu 
        195         


<210>  47
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  48
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp 
        115                 120                 125             


Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn 
    130                 135                 140                 


Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
145                 150                 155                 160 


Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro 
                165                 170                 175     


Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile 
            180                 185                 190         


Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala 
        195                 200                 205             


Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile 
    210                 215                 220                 


Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr 
225                 230                 235                 240 


Lys Phe 
        


<210>  49
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  50
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asp Tyr Glu Tyr Leu Ile Asn Val Ile His Ala Phe Gln Tyr Val 
1               5                   10                  15      


Ile Tyr Gly Thr Ala Ser Phe Phe Phe Leu Tyr Gly Ala Leu Leu Leu 
            20                  25                  30          


Ala Glu Gly Phe Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp 
        35                  40                  45              


Tyr Lys Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr Gly 
    50                  55                  60                  


Gly Gln Lys Gly Arg Gly Ser Arg Gly Gln His Gln Ala His Ser Leu 
65                  70                  75                  80  


Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys 
                85                  90                  95      


Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp Leu Leu Val Phe 
            100                 105                 110         


Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp Thr Thr 
        115                 120                 125             


Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser 
    130                 135                 140                 


Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro Trp Asn Ala Phe 
145                 150                 155                 160 


Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile Cys Lys Thr Ala 
                165                 170                 175     


Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala Phe Val Gly Ala 
            180                 185                 190         


Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile Ala Ala Thr Tyr 
        195                 200                 205             


Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr Lys Phe 
    210                 215                 220         


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 30-44

<400>  51

Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe 
1               5                   10                  15  


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 83-99

<400>  52

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr 
1               5                   10                  15      


Pro 
    


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 131-145

<400>  53

Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 140-154

<400>  54

Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRBP 1177-1191

<400>  55

Ala Asp Gly Ser Ser Trp Glu Gly Val Gly Val Val Pro Asp Val 
1               5                   10                  15  


<210>  56
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB-4K-GKK

<400>  56

Lys Lys Gly Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp 
1               5                   10                  15      


Val Thr Gly Lys Lys 
            20      


<210>  57
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB-5D-K1

<400>  57

Lys Lys Lys Lys Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB-9B

<400>  58

Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 1

<400>  59

Ile Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 2

<400>  60

Lys Gly Lys Lys Val Tyr Val Thr Leu Thr Cys Ala Phe Arg Tyr 
1               5                   10                  15  


<210>  61
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 3

<400>  61

Val Ile Gly Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln 
1               5                   10                  15      


Val Tyr Pro Pro Val Gly 
            20          


<210>  62
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 4

<400>  62

Glu Ser Leu Leu Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu 
1               5                   10                  15      


Thr Phe Pro Asp Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro 
            20                  25                  30          


Gln Asp Ser Gly Lys 
        35          


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 5

<400>  63

Ser Ser Val Arg Leu Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu 
1               5                   10                  15      


Met 
    


<210>  64
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 6

<400>  64

Ala Glu Ala Ala Trp Gln Phe Phe Met Ser Asp Lys Pro Leu His Leu 
1               5                   10                  15      


Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe 
            20                  25      


<210>  65
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 7

<400>  65

Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu Ala Asn Asn Arg Glu 
1               5                   10                  15      


Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys His Glu Asp Thr Asn 
            20                  25                  30          


Leu Ala Ser Ser Thr Ile Ile Lys Glu 
        35                  40      


<210>  66
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 8

<400>  66

Ile Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val 
1               5                   10                  15      


Lys Leu Thr Val Ser 
            20      


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-Arrestin Derived Peptide 9

<400>  67

Asn Thr Glu Lys Thr Val Lys Lys Ile Lys Ala Phe Val Glu Gln Val 
1               5                   10                  15      


Ala Asn Val Val Leu Tyr Ser Ser Asp Tyr Tyr Val Lys 
            20                  25                  


<210>  68
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-115

<400>  68

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val 
        35                  40          


<210>  69
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-115NE

<400>  69

His Val Ile Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr 
1               5                   10                  15      


Leu Gly Asn 
            


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-115NE1

<400>  70

Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile 
1               5                   10      


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-115NE2

<400>  71

Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr 
1               5                   10              


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-115NE3

<400>  72

Val Ile Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-115NE1-KKK

<400>  73

Lys Lys Lys Val Ile Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr 
1               5                   10                  15      


Ile Tyr Leu Gly Lys Lys Lys 
            20              


<210>  74
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-241125

<400>  74

Leu Thr Leu Leu Pro Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly Ile 
1               5                   10                  15      


Ala Leu Asp Gly Lys Ile Lys His Glu Asp Thr Asn Leu Ala Ser Ser 
            20                  25                  30          


Thr Ile Ile Lys Glu Gly 
        35              


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-11AC

<400>  75

Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys His Glu 
1               5                   10                  15      


Asp 
    


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-11AC1

<400>  76

Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys His 
1               5                   10              


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-11B

<400>  77

Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys His Glu 
1               5                   10                  15  


<210>  78
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-11JO

<400>  78

Asp Gly Lys Ile Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile 
1               5                   10                  15      


Ile Lys Glu Gly 
            20  


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-11JO1

<400>  79

His Glu Asp Thr Asn Leu Ala Ser Ser Thr 
1               5                   10  


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-11JO2

<400>  80

Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile 
1               5                   10          


<210>  81
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-11JO3

<400>  81

Ile Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile 
1               5                   10                  


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-11JO4

<400>  82

Lys Ile Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys 
1               5                   10                  15      


<210>  83
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-24DG

<400>  83

Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu Ala Asn Asn Arg Glu 
1               5                   10                  15      


Arg Arg 
        


<210>  84
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-24HM

<400>  84

Leu Thr Leu Leu Pro Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly Ile 
1               5                   10                  15      


Ala Leu Asp Gly 
            20  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-24HM1

<400>  85

Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly 
1               5                   10  


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-24HM2

<400>  86

Pro Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly Ile 
1               5                   10          


<210>  87
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-24HM3

<400>  87

Leu Pro Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala 
1               5                   10                  


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-24P

<400>  88

Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys 
1               5                   10                  15  


<210>  89
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-9FL

<400>  89

Val Lys Lys Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu 
1               5                   10                  15      


Tyr Ser Ser Asp Tyr 
            20      


<210>  90
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-9FL-KKK

<400>  90

Lys Lys Lys Val Lys Lys Ile Lys Ala Phe Val Glu Gln Val Ala Asn 
1               5                   10                  15      


Val Val Leu Tyr Ser Ser Asp Tyr Lys Lys Lys 
            20                  25          


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-9K1

<400>  91

Ala Phe Val Glu Gln Val Ala Asn Val Val Leu 
1               5                   10      


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-9K1-KKK

<400>  92

Lys Lys Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu Lys Lys 
1               5                   10                  15      


Lys 
    


<210>  93
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-17GN

<400>  93

Val Ile Gly Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln 
1               5                   10                  15      


Val Tyr Pro Pro Val Gly 
            20          


<210>  94
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-17GN-KKK

<400>  94

Lys Lys Lys Val Ile Gly Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser 
1               5                   10                  15      


Arg Val Gln Val Tyr Pro Pro Val Gly Lys Lys Lys 
            20                  25              


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-17J

<400>  95

Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr 
1               5                   10                  15  


<210>  96
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-17J-KKK

<400>  96

Lys Lys Lys Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln 
1               5                   10                  15      


Val Tyr Lys Lys Lys 
            20      


<210>  97
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-17K1

<400>  97

Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln 
1               5                   10          


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-17M1

<400>  98

Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln 
1               5                   10  


<210>  99
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-12AK

<400>  99

Ile Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val 
1               5                   10                  15      


Lys Leu Thr Val Ser Gly Phe Leu Gly 
            20                  25  


<210>  100
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-12AK-KKK

<400>  100

Lys Lys Lys Ile Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln 
1               5                   10                  15      


Ile Lys Val Lys Leu Thr Val Ser Gly Phe Leu Gly Lys Lys Lys 
            20                  25                  30      


<210>  101
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-12E

<400>  101

Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys Leu Thr 
1               5                   10                  15  


<210>  102
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-12E-KKK

<400>  102

Lys Lys Lys Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
1               5                   10                  15      


Leu Thr Lys Lys Lys 
            20      


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-12G1

<400>  103

Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
1               5                   10      


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP-12G1-KKK

<400>  104

Lys Lys Lys Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys Lys Lys 
1               5                   10                  15      


Lys 
    


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 1

<400>  105

Met Leu Thr Phe Leu His Glu Pro Ala Val Leu Phe Asn Leu Lys 
1               5                   10                  15  


<210>  106
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 2

<400>  106

Val Asn Pro Tyr Lys Trp Leu Pro Val Tyr Asn Ala Glu Trp 
1               5                   10                  


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 3

<400>  107

Pro His Ile Phe Ser Ile Ser Asp Asn Ala Tyr Gln Tyr Met Leu 
1               5                   10                  15  


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 4

<400>  108

Lys Arg Val Ile Gln Tyr Phe Ala Ser Ile Ala Ala Ile Gly Asp 
1               5                   10                  15  


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 5

<400>  109

Tyr His Ile Phe Tyr Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu 
1               5                   10                  15  


<210>  110
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 6

<400>  110

Lys Ser Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys 
1               5                   10                  15  


<210>  111
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 7

<400>  111

Lys Ser Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Ser Tyr Ala 
1               5                   10                  15  


<210>  112
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 8

<400>  112

Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn 
1               5                   10                  15  


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 9

<400>  113

Glu Ala Thr Leu Gln His Glu Ala Thr Ala Ala Ala Leu Arg Lys 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myosin Derived Peptide 10

<400>  114

Arg Val Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile Asn Gln 
1               5                   10                  15  


<210>  115
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5 (1)

<400>  115

Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Ser Phe Tyr Asn Leu Ser Lys Val Thr His Ile 
            20                  25                  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4 (2)

<400>  116

Leu Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser 
1               5                   10                  15      


Arg Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu 
            20                  25                  


<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4A

<400>  117

Leu Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile 
1               5                   10                  15  


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4B

<400>  118

Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser 
1               5                   10                  15  


<210>  119
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4C

<400>  119

Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
1               5                   10                  15  


<210>  120
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4D

<400>  120

Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg Ile 
1               5                   10                  15  


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4E

<400>  121

Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr 
1               5                   10                  15  


<210>  122
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4F


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  122

Xaa Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val 
1               5                   10                  15      


<210>  123
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4G

<400>  123

His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser 
1               5                   10                  15  


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4H

<400>  124

Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile 
1               5                   10                  15  


<210>  125
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4I

<400>  125

Phe Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp 
1               5                   10                  15  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4J

<400>  126

Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp Val 
1               5                   10                  15  


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4K

<400>  127

Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr 
1               5                   10                  15  


<210>  128
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4L

<400>  128

Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr Leu 
1               5                   10                  15  


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4M

<400>  129

Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr Leu Gln 
1               5                   10                  15  


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4N

<400>  130

Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln 
1               5                   10                  15  


<210>  131
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4J-GKK

<400>  131

Lys Lys Gly Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile 
1               5                   10                  15      


Asp Val Gly Lys Lys 
            20      


<210>  132
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4K-GKK

<400>  132

Lys Lys Gly Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp 
1               5                   10                  15      


Val Thr Gly Lys Lys 
            20      


<210>  133
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB_9 (3)

<400>  133

Thr Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp 
1               5                   10                  15      


Ile Phe Phe Ile Leu Glu Ile Thr Asp Asn Pro Tyr Met 
            20                  25                  


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 9A

<400>  134

Thr Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr 
1               5                   10                  15  


<210>  135
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 9B

<400>  135

Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp 
1               5                   10                  15  


<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 9C

<400>  136

Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp Ile 
1               5                   10                  15  


<210>  137
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 9D

<400>  137

Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp Thr Phe 
1               5                   10                  15  


<210>  138
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB_5A (6)

<400>  138

Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu 
1               5                   10                  15  


<210>  139
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB_5B (7)

<400>  139

Ser Arg Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15  


<210>  140
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5C (8)

<400>  140

Arg Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser 
1               5                   10                  15  


<210>  141
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5D (9)

<400>  141

Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His 
1               5                   10                  15  


<210>  142
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5E (10)

<400>  142

Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
1               5                   10                  15  


<210>  143
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5F (11)

<400>  143

Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser Phe 
1               5                   10                  15  


<210>  144
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5G

<400>  144

Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser Phe Tyr 
1               5                   10                  15  


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5H

<400>  145

Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser Phe Tyr Asn 
1               5                   10                  15  


<210>  146
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5I

<400>  146

Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser Phe Tyr Asn Leu 
1               5                   10                  15  


<210>  147
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5D-GKK (12)

<400>  147

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Gly Lys Lys 
            20      


<210>  148
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB_5E-GKK (13)

<400>  148

Lys Lys Gly Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser 
1               5                   10                  15      


His Ser Gly Lys Lys 
            20      


<210>  149
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5F-GKK (14)

<400>  149

Lys Lys Gly Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His 
1               5                   10                  15      


Ser Phe Gly Lys Lys 
            20      


<210>  150
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5J

<400>  150

Val Thr Leu Gln Gln Leu Glu Ser His Ser Phe Tyr Asn Leu Ser 
1               5                   10                  15  


<210>  151
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5K

<400>  151

Thr Leu Gln Gln Leu Glu Ser His Ser Phe Tyr Asn Leu Ser Lys 
1               5                   10                  15  


<210>  152
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5L

<400>  152

Leu Gln Gln Leu Glu Ser His Ser Phe Tyr Asn Leu Ser Lys Val 
1               5                   10                  15  


<210>  153
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5M

<400>  153

Gln Gln Leu Glu Ser His Ser Phe Tyr Asn Leu Ser Lys Val Thr 
1               5                   10                  15  


<210>  154
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5N

<400>  154

Gln Leu Glu Ser His Ser Phe Tyr Asn Leu Ser Lys Val Thr His 
1               5                   10                  15  


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 5O

<400>  155

Leu Glu Ser His Ser Phe Tyr Asn Leu Ser Lys Val Thr His Ile 
1               5                   10                  15  


<210>  156
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB_4J

<400>  156

Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp Val 
1               5                   10                  15  


<210>  157
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 4J-GKK

<400>  157

Lys Lys Gly Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile 
1               5                   10                  15      


Asp Val Gly Lys Lys 
            20      


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 9A (17)

<400>  158

Thr Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr 
1               5                   10                  15  


<210>  159
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 9B (18)

<400>  159

Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp 
1               5                   10                  15  


<210>  160
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB_9C (19)

<400>  160

Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp Ile 
1               5                   10                  15  


<210>  161
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 9D (20)

<400>  161

Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp Ile Phe 
1               5                   10                  15  


<210>  162
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (21

<400>  162

Lys Lys Lys Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  163
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (22)

<400>  163

Lys Lys Gly Lys Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Gly Lys Lys 
            20      


<210>  164
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (23)

<400>  164

Lys Lys Gly Ile Lys Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Gly Lys Lys 
            20      


<210>  165
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (24)

<400>  165

Lys Lys Gly Ile Tyr Lys Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Gly Lys Lys 
            20      


<210>  166
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (25)

<400>  166

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Lys Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Gly Lys Lys 
            20      


<210>  167
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (26)

<400>  167

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Lys Leu Glu 
1               5                   10                  15      


Ser His Gly Lys Lys 
            20      


<210>  168
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (27)

<400>  168

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Lys Glu 
1               5                   10                  15      


Ser His Gly Lys Lys 
            20      


<210>  169
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (28)

<400>  169

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Lys 
1               5                   10                  15      


Ser His Gly Lys Lys 
            20      


<210>  170
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (29)

<400>  170

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Lys His Gly Lys Lys 
            20      


<210>  171
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (30)

<400>  171

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser Lys Gly Lys Lys 
            20      


<210>  172
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (31)

<400>  172

Lys Lys Gly Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Gly 
1               5                   10                  15      


Lys Lys 
        


<210>  173
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (32)

<400>  173

Lys Lys Gly Tyr Val Ser Ile Asp Val Lys Leu Gln Gln Leu Glu Gly 
1               5                   10                  15      


Lys Lys 
        


<210>  174
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (33)

<400>  174

Lys Lys Gly Tyr Val Ser Ile Asp Val Thr Leu Gln Lys Leu Glu Gly 
1               5                   10                  15      


Lys Lys 
        


<210>  175
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (34)

<400>  175

Lys Lys Gly Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Lys Glu Gly 
1               5                   10                  15      


Lys Lys 
        


<210>  176
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (35)

<400>  176

Lys Lys Gly Tyr Val Ser Ile Asp Val Lys Leu Gln Lys Lys Glu Gly 
1               5                   10                  15      


Lys Lys 
        


<210>  177
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (36)

<400>  177

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  178
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (37)

<400>  178

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Lys Leu Gln Gln Leu Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  179
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (38)

<400>  179

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Lys Leu Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  180
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (39)

<400>  180

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Lys Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  181
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (40)

<400>  181

Lys Lys Gly Ile Tyr Val Ser Ile Asp Val Lys Leu Gln Lys Lys Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  182
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (41)

<400>  182

Lys Lys Gly Thr Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  183
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (42)

<400>  183

Lys Lys Gly Thr Tyr Val Ser Ile Asp Val Lys Leu Gln Gln Leu Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  184
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (43)

<400>  184

Lys Lys Gly Thr Tyr Val Ser Ile Asp Val Thr Leu Gln Lys Leu Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  185
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (44)

<400>  185

Lys Lys Gly Thr Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Lys Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  186
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (45)

<400>  186

Lys Lys Gly Thr Tyr Val Ser Ile Asp Val Lys Leu Gln Lys Lys Glu 
1               5                   10                  15      


Gly Lys Lys 
            


<210>  187
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (46)

<400>  187

Lys Lys Lys Lys Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  188
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (47)

<400>  188

Lys Lys Lys Ile Lys Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  189
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (48)

<400>  189

Lys Lys Lys Ile Tyr Lys Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  190
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (49)

<400>  190

Lys Lys Lys Ile Tyr Val Lys Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  191
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (50)

<400>  191

Lys Lys Lys Ile Tyr Val Ser Ile Asp Val Lys Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  192
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (51)

<400>  192

Lys Lys Lys Ile Tyr Val Ser Ile Asp Val Thr Leu Lys Gln Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  193
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (52)

<400>  193

Lys Lys Lys Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Lys Leu Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  194
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (53)

<400>  194

Lys Lys Lys Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Lys Glu 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  195
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (54)

<400>  195

Lys Lys Lys Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Lys 
1               5                   10                  15      


Ser His Lys Lys Lys 
            20      


<210>  196
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (55)

<400>  196

Lys Lys Lys Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Lys His Lys Lys Lys 
            20      


<210>  197
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (56)

<400>  197

Lys Lys Lys Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
1               5                   10                  15      


Ser Lys Lys Lys Lys 
            20      


<210>  198
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (57)

<400>  198

Lys Lys Lys Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Lys 
1               5                   10                  15      


Lys Lys 
        


<210>  199
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (58)

<400>  199

Lys Lys Lys Tyr Val Ser Ile Asp Val Lys Leu Gln Gln Leu Glu Lys 
1               5                   10                  15      


Lys Lys 
        


<210>  200
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (59)

<400>  200

Lys Lys Lys Tyr Val Ser Ile Asp Val Thr Leu Gln Lys Leu Glu Lys 
1               5                   10                  15      


Lys Lys 
        


<210>  201
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (60)

<400>  201

Lys Lys Lys Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Lys Glu Lys 
1               5                   10                  15      


Lys Lys 
        


<210>  202
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (61)

<400>  202

Lys Lys Lys Tyr Val Ser Ile Asp Val Lys Leu Gln Lys Lys Glu Lys 
1               5                   10                  15      


Lys Lys 
        


<210>  203
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (62)

<400>  203

Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr 
1               5                   10                  15  


<210>  204
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (63)

<400>  204

Lys Lys Gly Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp 
1               5                   10                  15      


Val Thr Gly Lys Lys 
            20      


<210>  205
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (64)

<400>  205

Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr 
1               5                   10                  15      


Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu 
            20                  25              


<210>  206
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (65)

<400>  206

Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr 
1               5                   10                  15      


<210>  207
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (66)

<400>  207

Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr 
1               5                   10                  15  


<210>  208
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (67)

<400>  208

Lys Lys Lys Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln 
1               5                   10                  15      


Gly Tyr Lys Lys Lys 
            20      


<210>  209
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (68)

<400>  209

Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala 
1               5                   10                  15  


<210>  210
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (69)

<400>  210

Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe 
1               5                   10                  15  


<210>  211
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (70)

<400>  211

Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn 
1               5                   10                  15  


<210>  212
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (71)

<400>  212

Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly 
1               5                   10                  15  


<210>  213
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (72)

<400>  213

Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr 
1               5                   10                  15  


<210>  214
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (73)

<400>  214

Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys 
1               5                   10                  15  


<210>  215
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (74)

<400>  215

Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu 
1               5                   10                  15  


<210>  216
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (75)

<400>  216

Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp 
1               5                   10                  15  


<210>  217
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (76)

<400>  217

Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala 
1               5                   10                  15  


<210>  218
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (77)

<400>  218

Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val 
1               5                   10                  15  


<210>  219
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thyroid Stimulating Hormone Receptor Derived Peptide (78)

<400>  219

Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr 
1               5                   10                  15  


<210>  220
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 1

<400>  220

Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His Gln Glu Glu 
1               5                   10                  15      


Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
            20                  25                  


<210>  221
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 2

<400>  221

Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro Ser 
1               5                   10                  15      


Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His 
            20                  25                  30  


<210>  222
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 3

<400>  222

Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
1               5                   10                  15      


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile 
            20                  25                  30  


<210>  223
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 6

<400>  223

Glu Ser His Ser Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile 
1               5                   10                  15      


Arg Asn Thr Arg Asn Leu Thr Tyr Ile Asp Pro Asp Ala 
            20                  25                  


<210>  224
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 7

<400>  224

Glu Ile Arg Asn Thr Arg Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu 
1               5                   10                  15      


Lys Glu Leu Pro Leu Leu Lys Phe Leu Gly Ile Phe Asn 
            20                  25                  


<210>  225
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 8

<400>  225

Leu Lys Glu Leu Pro Leu Leu Lys Phe Leu Gly Ile Phe Asn Thr Gly 
1               5                   10                  15      


Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr 
            20                  25                  


<210>  226
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 9

<400>  226

Thr Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp 
1               5                   10                  15      


Ile Phe Phe Ile Leu Glu Ile Thr Asp Asn Pro Tyr Met 
            20                  25                  


<210>  227
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 10

<400>  227

Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp Asn Pro Tyr Met Thr 
1               5                   10                  15      


Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys Asn Glu Thr 
            20                  25                  30  


<210>  228
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 11

<400>  228

Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys Asn Glu Thr Leu 
1               5                   10                  15      


Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            20                  25              


<210>  229
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 12

<400>  229

Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr 
1               5                   10                  15      


Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu 
            20                  25              


<210>  230
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 13

<400>  230

Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
1               5                   10                  15      


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala 
            20                  25              


<210>  231
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 14

<400>  231

Asn Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly 
1               5                   10                  15      


Val Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln 
            20                  25              


<210>  232
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 15

<400>  232

Phe Gly Gly Val Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr 
1               5                   10                  15      


Ser Val Thr Ala Leu Pro Ser Lys Gly Leu Glu His 
            20                  25              


<210>  233
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 16

<400>  233

Thr Ser Val Thr Ala Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu 
1               5                   10                  15      


Leu Ile Ala Arg Asn Thr Trp Thr Leu Lys Lys Leu 
            20                  25              


<210>  234
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 17

<400>  234

Leu Lys Glu Leu Ile Ala Arg Asn Thr Trp Thr Leu Lys Lys Leu Pro 
1               5                   10                  15      


Leu Ser Leu Ser Phe Leu His Leu Thr Arg Ala Asp 
            20                  25              


<210>  235
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 18

<400>  235

Pro Leu Ser Leu Ser Phe Leu His Leu Thr Arg Ala Asp Leu Ser Tyr 
1               5                   10                  15      


Pro Ser His Cys Cys Ala Phe Lys Asn Gln Lys Lys 
            20                  25              


<210>  236
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 19

<400>  236

Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn Gln Lys Lys Ile 
1               5                   10                  15      


Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
            20                  25              


<210>  237
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 20

<400>  237

Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser Ser Met Gln 
1               5                   10                  15      


Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn 
            20                  25              


<210>  238
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 21

<400>  238

Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser 
1               5                   10                  15      


Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser 
            20                  25                  


<210>  239
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 22

<400>  239

Ser Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val 
1               5                   10                  15      


Gly Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn 
            20                  25                  


<210>  240
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 23

<400>  240

Ile Val Gly Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn 
1               5                   10                  15      


Ala His Tyr Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu 
            20                  25                  


<210>  241
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 24

<400>  241

Asn Ala His Tyr Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile 
1               5                   10                  15      


Gly Phe Gly Gln Glu Leu Lys Asn Pro Gln Glu Glu Thr 
            20                  25                  


<210>  242
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 25

<400>  242

Ile Ile Gly Phe Gly Gln Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu 
1               5                   10                  15      


Gln Ala Phe Asp Ser His Tyr Asp Tyr Thr Ile Cys Gly 
            20                  25                  


<210>  243
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 26

<400>  243

Leu Gln Ala Phe Asp Ser His Tyr Asp Tyr Thr Ile Cys Gly Asp Ser 
1               5                   10                  15      


Glu Asp Met Val Cys Thr Pro Lys Ser Asp Glu Phe Asn 
            20                  25                  


<210>  244
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 27

<400>  244

Asp Ser Glu Asp Met Val Cys Thr Pro Lys Ser Asp Glu Phe Asn Pro 
1               5                   10                  15      


Cys Glu Asp Ile Met Gly Tyr Lys Phe Leu Arg 
            20                  25          


<210>  245
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNB 28

<400>  245

Lys Leu Asp Ala Val Tyr Leu Asn Lys Asn Lys Tyr Leu Thr Val Ile 
1               5                   10                  15      


Asp Lys Asp Ala Phe Gly Gly Val Tyr Ser Gly Pro Ser 
            20                  25                  


<210>  246
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 41-55

<400>  246

Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys 
1               5                   10                  15  


<210>  247
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 43-57

<400>  247

Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln 
1               5                   10                  15  


<210>  248
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 44-58

<400>  248

Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp 
1               5                   10                  15  


<210>  249
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 45-59

<400>  249

Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly 
1               5                   10                  15  


<210>  250
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 35-55

<400>  250

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  251
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG 40-60

<400>  251

Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys 
1               5                   10                  15      


Asp Gln Asp Gly Asp 
            20      


<210>  252
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 36-61

<400>  252

His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser 
1               5                   10                  15      


Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile 
            20                  25      


<210>  253
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 179-206

<400>  253

Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
1               5                   10                  15      


Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr 
            20                  25              


<210>  254
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 207-234

<400>  254

Gly Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn 
1               5                   10                  15      


Leu Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met 
            20                  25              


<210>  255
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 39-57

<400>  255

Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr 
1               5                   10                  15      


Gln Asp Tyr 
            


<210>  256
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 180-198

<400>  256

Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser 
1               5                   10                  15      


Ile Gly Ser 
            


<210>  257
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 208-222

<400>  257

Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn 
1               5                   10                  15  


<210>  258
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 39-53

<400>  258

Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn 
1               5                   10                  15  


<210>  259
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 42-56

<400>  259

Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp 
1               5                   10                  15  


<210>  260
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 43-57

<400>  260

Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr 
1               5                   10                  15  


<210>  261
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 180-194

<400>  261

Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
1               5                   10                  15  


<210>  262
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 181-195

<400>  262

Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser 
1               5                   10                  15  


<210>  263
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 182-196

<400>  263

Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile 
1               5                   10                  15  


<210>  264
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP183-197

<400>  264

Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly 
1               5                   10                  15  


<210>  265
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 184-198

<400>  265

Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser 
1               5                   10                  15  


<210>  266
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP 208-222

<400>  266

Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn 
1               5                   10                  15  


<210>  267
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-1

<400>  267

His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe 
1               5                   10                  15  


<210>  268
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-2

<400>  268

Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser 
1               5                   10                  15  


<210>  269
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-3

<400>  269

Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys 
1               5                   10                  15  


<210>  270
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-4

<400>  270

Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn 
1               5                   10                  15  


<210>  271
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-5

<400>  271

Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr 
1               5                   10                  15  


<210>  272
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-6

<400>  272

Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln 
1               5                   10                  15  


<210>  273
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-7

<400>  273

Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp 
1               5                   10                  15  


<210>  274
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-8

<400>  274

Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr 
1               5                   10                  15  


<210>  275
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-9

<400>  275

Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu 
1               5                   10                  15  


<210>  276
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-10

<400>  276

Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr 
1               5                   10                  15  


<210>  277
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-11

<400>  277

Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu 
1               5                   10                  15  


<210>  278
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-12

<400>  278

Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile 
1               5                   10                  15  


<210>  279
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-14

<400>  279

Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
1               5                   10                  15  


<210>  280
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-15

<400>  280

Thr Cys Gln Ser Ile Ala Pro Pro Ser Lys Thr Ser Ala Ser Ile 
1               5                   10                  15  


<210>  281
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-16

<400>  281

Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly 
1               5                   10                  15  


<210>  282
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP-18

<400>  282

Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser 
1               5                   10                  15  


<210>  283
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 1

<400>  283

Lys Lys Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Lys Lys 
            20      


<210>  284
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 2

<400>  284

Lys Lys Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Lys Glu 
            20      


<210>  285
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3

<400>  285

Lys Lys Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Glu Lys 
            20      


<210>  286
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4

<400>  286

Lys Lys Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Glu Glu 
            20      


<210>  287
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 5

<400>  287

Glu Glu Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Lys Lys 
            20      


<210>  288
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 6

<400>  288

Glu Glu Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Lys Glu 
            20      


<210>  289
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 7

<400>  289

Glu Glu Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Glu Lys 
            20      


<210>  290
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8

<400>  290

Glu Glu Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Glu Glu 
            20      


<210>  291
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9

<400>  291

Lys Glu Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Lys Glu 
            20      


<210>  292
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 10

<400>  292

Lys Glu Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Lys Glu 
            20      


<210>  293
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11

<400>  293

Lys Glu Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Glu Lys 
            20      


<210>  294
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12

<400>  294

Lys Glu Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Glu Glu 
            20      


<210>  295
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 13

<400>  295

Glu Lys Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Lys Lys 
            20      


<210>  296
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 14

<400>  296

Glu Lys Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Lys Glu 
            20      


<210>  297
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 15

<400>  297

Glu Lys Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Glu Lys 
            20      


<210>  298
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 16

<400>  298

Glu Lys Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Glu Glu 
            20      


<210>  299
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 17

<400>  299

Lys Lys Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Lys Lys 
            20      


<210>  300
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 18

<400>  300

Lys Lys Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Lys Glu 
            20      


<210>  301
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 19

<400>  301

Lys Lys Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Glu Lys 
            20      


<210>  302
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 20

<400>  302

Lys Lys Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Glu Glu 
            20      


<210>  303
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 21

<400>  303

Glu Glu Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Lys Lys 
            20      


<210>  304
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 22

<400>  304

Glu Glu Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Lys Glu 
            20      


<210>  305
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 23

<400>  305

Glu Glu Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Glu Lys 
            20      


<210>  306
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 34

<400>  306

Glu Glu Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Glu Glu 
            20      


<210>  307
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 25

<400>  307

Lys Glu Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Lys Lys 
            20      


<210>  308
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 26

<400>  308

Lys Glu Gly Asp Asn Ile Met Val Thr Phe Arg Asn Ser Gln Ala Ser 
1               5                   10                  15      


Arg Pro Tyr Gly Lys Glu 
            20          


<210>  309
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 27

<400>  309

Lys Glu Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Glu Lys 
            20      


<210>  310
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 28

<400>  310

Lys Glu Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Glu Glu 
            20      


<210>  311
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 29

<400>  311

Glu Lys Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Lys Lys 
            20      


<210>  312
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 30

<400>  312

Glu Lys Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Lys Glu 
            20      


<210>  313
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 31

<400>  313

Glu Lys Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Glu Lys 
            20      


<210>  314
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 32

<400>  314

Glu Lys Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Glu Glu 
            20      


<210>  315
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 34

<400>  315

Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
1               5                   10                  15  


<210>  316
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 35

<400>  316

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu 
1               5                   10                  15  


<210>  317
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 36

<400>  317

Pro Arg Cys Leu Thr 
1               5   


<210>  318
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 37

<400>  318

Asp Asn Ile Met Val 
1               5   


<210>  319
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 38, X is K or E


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  319

Xaa Xaa Gly Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15      


Pro Tyr Gly Xaa Xaa 
            20      


<210>  320
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 39, X is K or E


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  320

Xaa Xaa Gly Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15      


Met Glu Gly Xaa Xaa 
            20      


<210>  321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 40

<400>  321

Ala Ser Gln Tyr Arg Pro Ser Gln Arg 
1               5                   


<210>  322
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 1

<400>  322

Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile 
1               5                   10                  15  


<210>  323
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 2

<400>  323

Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp 
1               5                   10                  15  


<210>  324
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3

<400>  324

Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly 
1               5                   10                  15  


<210>  325
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.1

<400>  325

Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met 
1               5                   10                  15  


<210>  326
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.2

<400>  326

Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr 
1               5                   10                  15  


<210>  327
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.3

<400>  327

Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser 
1               5                   10                  15  


<210>  328
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.4

<400>  328

Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu 
1               5                   10                  15  


<210>  329
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.5

<400>  329

Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp 
1               5                   10                  15  


<210>  330
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.6

<400>  330

Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly 
1               5                   10                  15  


<210>  331
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.7

<400>  331

Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys 
1               5                   10                  15  


<210>  332
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.8

<400>  332

Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
1               5                   10                  15  


<210>  333
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.9

<400>  333

Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp 
1               5                   10                  15  


<210>  334
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.10

<400>  334

Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln 
1               5                   10                  15  


<210>  335
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3.11

<400>  335

Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr 
1               5                   10                  15  


<210>  336
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4

<400>  336

Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr 
1               5                   10                  15  


<210>  337
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.1

<400>  337

His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 
1               5                   10                  15  


<210>  338
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.2

<400>  338

Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His 
1               5                   10                  15  


<210>  339
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.3

<400>  339

Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro 
1               5                   10                  15  


<210>  340
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.4

<400>  340

Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr 
1               5                   10                  15  


<210>  341
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.5

<400>  341

Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His 
1               5                   10                  15  


<210>  342
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.6

<400>  342

Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr 
1               5                   10                  15  


<210>  343
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.7

<400>  343

Pro Glu Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser 
1               5                   10                  


<210>  344
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.8

<400>  344

Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile 
1               5                   10                  15  


<210>  345
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.9

<400>  345

Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1               5                   10                  15  


<210>  346
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.10

<400>  346

Ala Arg Tyr Glu Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser 
1               5                   10                  15  


<210>  347
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4.11

<400>  347

Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr 
1               5                   10                  15  


<210>  348
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 5

<400>  348

Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Ser Trp 
1               5                   10                  15      


<210>  349
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 6

<400>  349

Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu 
1               5                   10                  15  


<210>  350
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 7

<400>  350

Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
1               5                   10                  15  


<210>  351
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8

<400>  351

Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr 
1               5                   10                  15  


<210>  352
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.1

<400>  352

Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln 
1               5                   10                  15  


<210>  353
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.2

<400>  353

Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala 
1               5                   10                  15  


<210>  354
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.3

<400>  354

Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser 
1               5                   10                  15  


<210>  355
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.4

<400>  355

Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
1               5                   10                  15  


<210>  356
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.5

<400>  356

Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro 
1               5                   10                  15  


<210>  357
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.6

<400>  357

Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr 
1               5                   10                  15  


<210>  358
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.7

<400>  358

Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn 
1               5                   10                  15  


<210>  359
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.8

<400>  359

Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile 
1               5                   10                  15  


<210>  360
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.9

<400>  360

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
1               5                   10                  15  


<210>  361
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.10

<400>  361

Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
1               5                   10                  15  


<210>  362
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8.11

<400>  362

Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Gly Tyr Pro His 
1               5                   10                  15  


<210>  363
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9

<400>  363

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu 
1               5                   10                  15  


<210>  364
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.1

<400>  364

Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser 
1               5                   10                  15  


<210>  365
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.2

<400>  365

Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe 
1               5                   10                  15  


<210>  366
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.3

<400>  366

Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val 
1               5                   10                  15  


<210>  367
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.4

<400>  367

Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn 
1               5                   10                  15  


<210>  368
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.5

<400>  368

Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met 
1               5                   10                  15  


<210>  369
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.6

<400>  369

Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu 
1               5                   10                  15  


<210>  370
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.7

<400>  370

Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
1               5                   10                  15  


<210>  371
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.8

<400>  371

Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp 
1               5                   10                  15  


<210>  372
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.9

<400>  372

Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu 
1               5                   10                  15  


<210>  373
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.10

<400>  373

Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
1               5                   10                  15  


<210>  374
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9.11

<400>  374

Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser 
1               5                   10                  15  


<210>  375
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 10

<400>  375

Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln 
1               5                   10                  15  


<210>  376
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11

<400>  376

Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
1               5                   10                  15  


<210>  377
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.1

<400>  377

Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 
1               5                   10                  15  


<210>  378
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.2

<400>  378

Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala 
1               5                   10                  15  


<210>  379
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.3

<400>  379

Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser 
1               5                   10                  15  


<210>  380
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.4

<400>  380

Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
1               5                   10                  15  


<210>  381
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.5

<400>  381

Glu Asp Asn Thr Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro 
1               5                   10                  15  


<210>  382
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.6

<400>  382

Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
1               5                   10                  15  


<210>  383
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.7

<400>  383

Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser 
1               5                   10                  15  


<210>  384
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.8

<400>  384

Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe 
1               5                   10                  15  


<210>  385
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.9

<400>  385

Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr 
1               5                   10                  15  


<210>  386
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.10

<400>  386

Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
1               5                   10                  15  


<210>  387
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11.11

<400>  387

Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser 
1               5                   10                  15  


<210>  388
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12

<400>  388

Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala 
1               5                   10                  15  


<210>  389
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.1

<400>  389

Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp 
1               5                   10                  15  


<210>  390
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.2

<400>  390

Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val 
1               5                   10                  15  


<210>  391
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.3

<400>  391

Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His 
1               5                   10                  15  


<210>  392
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.4

<400>  392

Leu Thr Arg Tyr Leu Arg Glu His Pro Gln Ser Trp Val His Gln 
1               5                   10                  15  


<210>  393
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.5

<400>  393

Thr Arg Tyr Leu Arg Phe Phe Leu Pro Gln Ser Trp Val His Gln Ile 
1               5                   10                  15      


<210>  394
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.6

<400>  394

Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala 
1               5                   10                  15  


<210>  395
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.7

<400>  395

Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1               5                   10                  15  


<210>  396
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.8

<400>  396

Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg 
1               5                   10                  15  


<210>  397
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.9

<400>  397

Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met 
1               5                   10                  15  


<210>  398
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.10

<400>  398

Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu 
1               5                   10                  15  


<210>  399
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12.11

<400>  399

His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val 
1               5                   10                  15  


<210>  400
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 1

<400>  400

Leu Tyr Ile Ser Gln Phe Ile Ile Met Met Tyr Ser Leu Asp Gly Lys 
1               5                   10                  15      


<210>  401
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 2

<400>  401

Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr 
1               5                   10                  15  


<210>  402
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 3

<400>  402

Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser 
1               5                   10                  15  


<210>  403
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 4

<400>  403

Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
1               5                   10                  15  


<210>  404
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 5

<400>  404

Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile 
1               5                   10                  15  


<210>  405
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 6

<400>  405

Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn 
1               5                   10                  15  


<210>  406
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 7

<400>  406

Gly Asp Thr Leu Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro 
1               5                   10                  15      


<210>  407
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 8

<400>  407

Val Gly Asp Thr Leu Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg 
1               5                   10                  15      


<210>  408
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 9

<400>  408

Glu Val Gly Asp Thr Leu Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser 
1               5                   10                  15      


<210>  409
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 10

<400>  409

Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp 
1               5                   10                  15  


<210>  410
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 11

<400>  410

Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro 
1               5                   10                  15  


<210>  411
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 12

<400>  411

Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile 
1               5                   10                  15  


<210>  412
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FVIII Derived Peptide 13

<400>  412

Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln 
1               5                   10                  15  


<210>  413
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 1

<400>  413

Ala Ser Ser Arg Gly Tyr Glu Asp Leu Arg Phe 
1               5                   10      


<210>  414
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 2

<400>  414

Leu Asp Asn Ser Tyr His Asp Asn Pro Val 
1               5                   10  


<210>  415
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 3

<400>  415

Leu Arg Ala Pro Ala Gly Leu Gly Ala Ala 
1               5                   10  


<210>  416
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 4

<400>  416

Gly Ala Arg Cys Ile Asn Ala Glu Gln Pro 
1               5                   10  


<210>  417
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 5

<400>  417

Tyr Ser Cys Leu Lys Leu Tyr Ser Phe Ala 
1               5                   10  


<210>  418
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 6

<400>  418

Glu His Ala Thr Gln Asn Gln Val Ser Val 
1               5                   10  


<210>  419
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 7

<400>  419

Gly Thr Gly Ser Gly Gln Gly Glu Glu Ala 
1               5                   10  


<210>  420
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 8

<400>  420

Ala Asp Asp Asn Phe Ser Ile Pro Glu Gly 
1               5                   10  


<210>  421
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 9

<400>  421

Ala Ser Ser Arg Gly Tyr Glu Asp Leu Arg 
1               5                   10  


<210>  422
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 10

<400>  422

Leu Asp Asn Ser Tyr His Asp Asn Pro Val Val Ser Lys Glu Leu Arg 
1               5                   10                  15      


Ile Glu Gly Asn Gln Leu Thr 
            20              


<210>  423
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 11

<400>  423

Gly Ala Arg Cys Ile Asn Ala Glu Gln Pro Cys Gln Ser Pro 
1               5                   10                  


<210>  424
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Autoantibody Binding Peptide Related To Multiple Sclerosis 12

<400>  424

Tyr Ser Cys Leu Lys Leu Tyr Ser Phe Ala Asn 
1               5                   10      


<210>  425
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 134-148

<400>  425

Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly 
1               5                   10                  15  


<210>  426
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 135-149

<400>  426

Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
1               5                   10                  15  


<210>  427
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 136-150

<400>  427

Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu 
1               5                   10                  15  


<210>  428
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 137-151

<400>  428

Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser 
1               5                   10                  15  


<210>  429
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 138-152

<400>  429

His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys 
1               5                   10                  15  


<210>  430
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 139-153

<400>  430

Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile 
1               5                   10                  15  


<210>  431
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 140-154

<400>  431

Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
1               5                   10                  15  


<210>  432
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 83-99

<400>  432

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr 
1               5                   10                  15      


Pro 
    


<210>  433
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 80-94

<400>  433

Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val 
1               5                   10                  15  


<210>  434
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 81-95

<400>  434

Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
1               5                   10                  15  


<210>  435
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 82-96

<400>  435

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro 
1               5                   10                  15  


<210>  436
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 83-97

<400>  436

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15  


<210>  437
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 84-98

<400>  437

Met Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr 
1               5                   10                  15  


<210>  438
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 130-144

<400>  438

Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val 
1               5                   10                  15  


<210>  439
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 131-145

<400>  439

Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp 
1               5                   10                  15  


<210>  440
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 132-146

<400>  440

Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala 
1               5                   10                  15  


<210>  441
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP 133-147

<400>  441

Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln 
1               5                   10                  15  


<210>  442
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  442

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  443
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  443

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
        195                 200                 205             


<210>  444
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
    210                 215                 220                 


<210>  445
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 
            20                  25                  30          


Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 
        35                  40                  45              


Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 
    50                  55                  60                  


Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 
65                  70                  75                  80  


Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu Phe 
                85                  90                  95      


Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr 
            100                 105                 110         


Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu Arg 
        115                 120                 125             


Asn Pro Phe 
    130     


<210>  446
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 
                245                 250         


<210>  447
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  447

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
        195                 200                 205             


Glu Ala Leu Ser Gly 
    210             


<210>  448
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205             


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
    210                 215                 220                 


Glu Ala Leu Ser Gly 
225                 


<210>  449
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  449

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Leu Phe His Leu Glu Ala Leu Ser Gly 
        195                 200                 205     


<210>  450
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Gly Lys Phe Arg His Val 
        195                 200             


<210>  451
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  451

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Val Ser His Ser Val Thr Gln Asp Trp Leu Gln Trp His Asp His 
145                 150                 155                 160 


Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu Lys 
                165                 170     


<210>  452
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Val Phe His Leu Glu Ala Leu Ser Gly 
        195                 200                 205     


<210>  453
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  453

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe 
            20                  25                  30          


Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val 
        35                  40                  45              


Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu Cys Leu Gln Tyr 
    50                  55                  60                  


Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr 
65                  70                  75                  80  


Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys Glu Pro Lys Lys 
                85                  90                  95      


Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
            100                 105             


<210>  454
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  454

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Lys Phe Ser Ser Leu Cys Tyr Lys Gln Arg Ile Lys 
                245                 250                 255     


Ser Gln Glu Arg Glu Thr Glu Ala Thr Arg Gly Arg Gly Gly Leu Leu 
            260                 265                 270         


Arg Asp His Ile Pro Arg Gly Lys Glu Glu Leu Glu Ser Leu Gly Gly 
        275                 280                 285             


Gly Lys Thr Pro Pro Gly Arg 
    290                 295 


<210>  455
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  455

Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe Tyr Trp 
            20                  25                  30          


Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val Leu Leu 
        35                  40                  45              


Leu Gln Ile Thr Val Gly Leu Val Phe Leu Cys Leu Gln Tyr Arg Leu 
    50                  55                  60                  


Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr Phe Gly 
65                  70                  75                  80  


Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
                85                  90  


<210>  456
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  456

Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Asp Pro Phe Tyr Trp 
            20                  25                  30          


Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val Leu Leu 
        35                  40                  45              


Leu Gln Ile Thr Val Gly Leu Val Phe Leu Cys Leu Gln Tyr Arg Leu 
    50                  55                  60                  


Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr Phe Glu 
65                  70                  75                  80  


Ser Phe Gly Val Leu Gly Pro Gln Val Lys Glu Pro Lys Lys Thr Gly 
                85                  90                  95      


Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
            100                 105     


<210>  457
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  457

Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe Arg Val 
            20                  25                  30          


Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu Val Glu 
        35                  40                  45              


Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val 
    50                  55                  60                  


Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn 
65                  70                  75                  80  


Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu Arg Ile 
            100                 105                 110         


Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe Phe Arg 
        115                 120                 125             


Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val Glu Gly 
    130                 135                 140                 


Leu Val Ala Val Ala Arg Ser Trp Leu Ile Ala Ala Ser Thr Ser Gln 
145                 150                 155                 160 


Ala Gln Val Ile Leu Leu Thr Gln Pro Leu Glu 
                165                 170     


<210>  458
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  458

Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Val Ser His Ser Val 
            20                  25                  30          


Thr Gln Asp Trp Leu Gln Trp His Asp His Gly Ser Leu Gln Pro Pro 
        35                  40                  45              


Pro Pro Arg Leu Lys 
    50              


<210>  459
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  459

Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Leu Val Ala Val 
            20                  25                  30          


Ala Arg Ser Trp Leu Ile Ala Ala Ser Thr Ser Gln Ala Gln Val Ile 
        35                  40                  45              


Leu Leu Thr Gln Pro Leu Glu 
    50                  55  


<210>  460
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  460

Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe Arg Val 
            20                  25                  30          


Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu Val Glu 
        35                  40                  45              


Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val 
    50                  55                  60                  


Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn 
65                  70                  75                  80  


Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu Arg Ile 
            100                 105                 110         


Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe Phe Arg 
        115                 120                 125             


Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val Glu Ala 
    130                 135                 140                 


Pro Leu Lys Gln Arg Ser Arg 
145                 150     


<210>  461
<211>  744
<212>  DNA
<213>  Mus musculus

<400>  461
atggcctgtt tgtggagctt ctcttggccc agctgcttcc tctcccttct cctcctcctt       60

ctcctccagt tgtcatgcag ctatgcagga caattcagag tgataggacc agggtatccc      120

atccgggctt tagttgggga tgaagcagag ctgccgtgcc gcatctctcc tgggaaaaat      180

gccacgggca tggaggtggg ttggtaccgt tctcccttct caagagtggt tcacctctac      240

cgaaatggca aggaccaaga tgcagagcaa gcacctgaat accggggacg cacagagctt      300

ctgaaagaga ctatcagtga gggaaaggtt acccttagga ttcagaacgt gagattctca      360

gatgaaggag gctacacctg cttcttcaga gaccactctt accaagaaga ggcagcaatg      420

gagttgaaag tggaagatcc cttctattgg gtcaaccccg gtgtgctgac tctcatcgca      480

cttgtgccta cgatcctcct gcaggtctct gtaggccttg tattcctctt cctgcagcac      540

agactgagag gaaaacttcg tgcagaagta gagaatctcc atcggacttt tgatcctcac      600

ttcctgaggg tgccctgctg gaagataaca ctgtttgtta ttgtgcctgt tcttggaccc      660

ctggttgcct tgatcctgtg ctacaactgg ctgcaccgaa gactggcagg acagtttctt      720

gaagagctaa gaaacccctt ttga                                             744


<210>  462
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human chymotrypsinogen B2 signal peptide+ Mus musculus mini-MOG 
       cDNA (start to stop)

<400>  462
atggcctttc tgtggctgct gtcctgctgg gccctgctgg ggaccacctt tggcggacaa       60

ttcagagtga taggaccagg gtatcccatc cgggctttag ttggggatga agcagagctg      120

ccgtgccgca tctctcctgg gaaaaatgcc acgggcatgg aggtgggttg gtaccgttct      180

cccttctcaa gagtggttca cctctaccga aatggcaagg accaagatgc agagcaagca      240

cctgaatacc ggggacgcac agagcttctg aaagagacta tcagtgaggg aaaggttacc      300

cttaggattc agaacgtgag attctcagat gaaggaggct acacctgctt cttcagagac      360

cactcttacc aagaagaggc agcaatggag ttgaaagtgg aagatccctt ctattgggtc      420

aaccccggtg tgctgacttg a                                                441


<210>  463
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM1-miniMOG (aa29-178)

<400>  463

Gly Gln Phe Arg Val Ile Gly Pro Gly Tyr Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala 
            20                  25                  30          


Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val 
        35                  40                  45              


His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Thr Glu Leu Leu Lys Glu Thr Ile Ser Glu Gly Lys 
65                  70                  75                  80  


Val Thr Leu Arg Ile Gln Asn Val Arg Phe Ser Asp Glu Gly Gly Tyr 
                85                  90                  95      


Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu 
            100                 105                 110         


Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Asn Pro Gly Val Leu Thr 
        115                 120                 125             


Leu Ile Ala Leu Val Pro Thr Ile Leu Leu Gln Val Pro Val Gly Leu 
    130                 135                 140                 


Val Phe Leu Phe Leu Thr 
145                 150 


<210>  464
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM0.6-miniMOG

<400>  464

Gly Gln Phe Arg Val Ile Gly Pro Gly Tyr Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala 
            20                  25                  30          


Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val 
        35                  40                  45              


His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Thr Glu Leu Leu Lys Glu Thr Ile Ser Glu Gly Lys 
65                  70                  75                  80  


Val Thr Leu Arg Ile Gln Asn Val Arg Phe Ser Asp Glu Gly Gly Tyr 
                85                  90                  95      


Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu 
            100                 105                 110         


Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Asn Pro Gly Val Leu Thr 
        115                 120                 125             


Leu Ile Ala Leu Val Pro Thr Ile Leu Leu Gln Val Pro 
    130                 135                 140     


<210>  465
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM0.3-miniMOG

<400>  465

Gly Gln Phe Arg Val Ile Gly Pro Gly Tyr Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala 
            20                  25                  30          


Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val 
        35                  40                  45              


His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Thr Glu Leu Leu Lys Glu Thr Ile Ser Glu Gly Lys 
65                  70                  75                  80  


Val Thr Leu Arg Ile Gln Asn Val Arg Phe Ser Asp Glu Gly Gly Tyr 
                85                  90                  95      


Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu 
            100                 105                 110         


Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Asn Pro Gly Val Leu Thr 
        115                 120                 125             


Leu Ile Ala Leu Val Pro 
    130                 


<210>  466
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mus musculus MOG 1-117

<400>  466

Gly Gln Phe Arg Val Ile Gly Pro Gly Tyr Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala 
            20                  25                  30          


Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val 
        35                  40                  45              


His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Thr Glu Leu Leu Lys Glu Thr Ile Ser Glu Gly Lys 
65                  70                  75                  80  


Val Thr Leu Arg Ile Gln Asn Val Arg Phe Ser Asp Glu Gly Gly Tyr 
                85                  90                  95      


Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu 
            100                 105                 110         


Leu Lys Val Glu Asp 
        115         


<210>  467
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens MOG 1-117

<400>  467

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala 
            20                  25                  30          


Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val 
        35                  40                  45              


His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys 
65                  70                  75                  80  


Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe 
                85                  90                  95      


Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu 
            100                 105                 110         


Leu Lys Val Glu Asp 
        115         


<210>  468
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Macaca mulatta MOG 1-117

<400>  468

Gly Gln Phe Arg Val Ile Gly Pro Arg Gln Pro Ile Arg Ala Leu Val 
1               5                   10                  15      


Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala 
            20                  25                  30          


Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val 
        35                  40                  45              


His Leu Tyr Arg Asn Gly Arg Asp Gln Asp Gly Glu Gln Ala Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys 
65                  70                  75                  80  


Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe 
                85                  90                  95      


Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Ile Glu 
            100                 105                 110         


Leu Lys Val Glu Asp 
        115         


<210>  469
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Callithrix jacchus MOG 1-117

<400>  469

Gly Gln Phe Arg Val Ile Gly Pro Ser His Pro Ile Gln Ala Leu Val 
1               5                   10                  15      


Gly Asp Ala Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala 
            20                  25                  30          


Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val 
        35                  40                  45              


His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Glu Gln Ala Pro Glu 
    50                  55                  60                  


Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Asp Ile Gly Glu Gly Lys 
65                  70                  75                  80  


Val Thr Leu Lys Ile Arg Asn Val Arg Phe Pro Asp Glu Gly Gly Phe 
                85                  90                  95      


Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Gln 
            100                 105                 110         


Leu Lys Val Glu Asp 
        115         


<210>  470
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human chymotrypsinogen B2 signal peptide+ Mus musculus MOG 1-117

<400>  470

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Gly Gln Phe Arg Val Ile Gly Pro Gly Tyr Pro Ile Arg Ala 
            20                  25                  30          


Leu Val Gly Asp Glu Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys 
        35                  40                  45              


Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg 
    50                  55                  60                  


Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala 
65                  70                  75                  80  


Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Glu Thr Ile Ser Glu 
                85                  90                  95      


Gly Lys Val Thr Leu Arg Ile Gln Asn Val Arg Phe Ser Asp Glu Gly 
            100                 105                 110         


Gly Tyr Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala 
        115                 120                 125             


Met Glu Leu Lys Val Glu Asp 
    130                 135 


<210>  471
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human chymotrypsinogen B2 signal peptide+ Homo sapiens MOG 1-117

<400>  471

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala 
            20                  25                  30          


Leu Val Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys 
        35                  40                  45              


Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg 
    50                  55                  60                  


Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala 
65                  70                  75                  80  


Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu 
                85                  90                  95      


Gly Lys Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly 
            100                 105                 110         


Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala 
        115                 120                 125             


Met Glu Leu Lys Val Glu Asp 
    130                 135 


<210>  472
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human chymotrypsinogen B2 signal peptide+ Macaca mulatta MOG 
       1-117

<400>  472

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Gly Gln Phe Arg Val Ile Gly Pro Arg Gln Pro Ile Arg Ala 
            20                  25                  30          


Leu Val Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys 
        35                  40                  45              


Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg 
    50                  55                  60                  


Val Val His Leu Tyr Arg Asn Gly Arg Asp Gln Asp Gly Glu Gln Ala 
65                  70                  75                  80  


Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu 
                85                  90                  95      


Gly Lys Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly 
            100                 105                 110         


Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala 
        115                 120                 125             


Ile Glu Leu Lys Val Glu Asp 
    130                 135 


<210>  473
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human chymotrypsinogen B2 signal peptide+ Callithrix jacchus MOG 
       1-117

<400>  473

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Gly Gln Phe Arg Val Ile Gly Pro Ser His Pro Ile Gln Ala 
            20                  25                  30          


Leu Val Gly Asp Ala Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys 
        35                  40                  45              


Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg 
    50                  55                  60                  


Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Glu Gln Ala 
65                  70                  75                  80  


Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Asp Ile Gly Glu 
                85                  90                  95      


Gly Lys Val Thr Leu Lys Ile Arg Asn Val Arg Phe Pro Asp Glu Gly 
            100                 105                 110         


Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala 
        115                 120                 125             


Met Gln Leu Lys Val Glu Asp 
    130                 135 


<210>  474
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TM1-miniMOG (aa29-178)

<400>  474
ggacaattca gagtgatagg accagggtat cccatccggg ctttagttgg ggatgaagca       60

gagctgccgt gccgcatctc tcctgggaaa aatgccacgg gcatggaggt gggttggtac      120

cgttctccct tctcaagagt ggttcacctc taccgaaatg gcaaggacca agatgcagag      180

caagcacctg aataccgggg acgcacagag cttctgaaag agactatcag tgagggaaag      240

gttaccctta ggattcagaa cgtgagattc tcagatgaag gaggctacac ctgcttcttc      300

agagaccact cttaccaaga agaggcagca atggagttga aagtggaaga tcccttctat      360

tgggtcaacc ccggtgtgct gactctcatc gcacttgtgc ctacgatcct cctgcaggtc      420

tctgtaggcc ttgtattcct cttcctg                                          447


<210>  475
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TM0.6-miniMOG (aa29-169)

<400>  475
ggacaattca gagtgatagg accagggtat cccatccggg ctttagttgg ggatgaagca       60

gagctgccgt gccgcatctc tcctgggaaa aatgccacgg gcatggaggt gggttggtac      120

cgttctccct tctcaagagt ggttcacctc taccgaaatg gcaaggacca agatgcagag      180

caagcacctg aataccgggg acgcacagag cttctgaaag agactatcag tgagggaaag      240

gttaccctta ggattcagaa cgtgagattc tcagatgaag gaggctacac ctgcttcttc      300

agagaccact cttaccaaga agaggcagca atggagttga aagtggaaga tcccttctat      360

tgggtcaacc ccggtgtgct gactctcatc gcacttgtgc ctacgatcct cctgcaggtc      420

tct                                                                    423


<210>  476
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TM0.3-miniMOG (aa29-162)

<400>  476
ggacaattca gagtgatagg accagggtat cccatccggg ctttagttgg ggatgaagca       60

gagctgccgt gccgcatctc tcctgggaaa aatgccacgg gcatggaggt gggttggtac      120

cgttctccct tctcaagagt ggttcacctc taccgaaatg gcaaggacca agatgcagag      180

caagcacctg aataccgggg acgcacagag cttctgaaag agactatcag tgagggaaag      240

gttaccctta ggattcagaa cgtgagattc tcagatgaag gaggctacac ctgcttcttc      300

agagaccact cttaccaaga agaggcagca atggagttga aagtggaaga tcccttctat      360

tgggtcaacc ccggtgtgct gactctcatc gcacttgtgc ct                         402


<210>  477
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP1 (aa37-63)

<400>  477

His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser 
1               5                   10                  15      


Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn 
            20                  25          


<210>  478
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP1 + TM1 (aa10-63)

<400>  478

Cys Leu Val Gly Ala Pro Phe Ala Ser Leu Val Ala Thr Gly Leu Cys 
1               5                   10                  15      


Phe Phe Gly Val Ala Leu Phe Cys Gly Cys Gly His Glu Ala Leu Thr 
            20                  25                  30          


Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp 
        35                  40                  45              


Tyr Glu Tyr Leu Ile Asn 
    50                  


<210>  479
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP2 (aa89-151)

<400>  479

Glu Gly Phe Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp Tyr 
1               5                   10                  15      


Lys Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr Gly Gly 
            20                  25                  30          


Gln Lys Gly Arg Gly Ser Arg Gly Gln His Gln Ala His Ser Leu Glu 
        35                  40                  45              


Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys 
    50                  55                  60              


<210>  480
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP2 + TM2 (aa64-151)

<400>  480

Val Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe 
1               5                   10                  15      


Phe Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly 
            20                  25                  30          


Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys 
        35                  40                  45              


Gly Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg 
    50                  55                  60                  


Gly Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly 
65                  70                  75                  80  


Lys Trp Leu Gly His Pro Asp Lys 
                85              


<210>  481
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP3 (aa178-233)

<400>  481

Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr 
1               5                   10                  15      


Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val 
            20                  25                  30          


Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu 
        35                  40                  45              


Ser Ile Cys Lys Thr Ala Glu Phe 
    50                  55      


<210>  482
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP3 + TM3 (aa152-233)

<400>  482

Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp Leu Leu Val Phe 
1               5                   10                  15      


Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp Thr Thr 
            20                  25                  30          


Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser 
        35                  40                  45              


Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro Trp Asn Ala Phe 
    50                  55                  60                  


Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile Cys Lys Thr Ala 
65                  70                  75                  80  


Glu Phe 
        


<210>  483
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP4 (aa261-277)

<400>  483

Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr Lys 
1               5                   10                  15      


Phe 
    


<210>  484
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP4 + TM4 (aa234-277)

<400>  484

Gln Met Thr Phe His Leu Phe Ile Ala Ala Phe Val Gly Ala Ala Ala 
1               5                   10                  15      


Thr Leu Val Ser Leu Leu Thr Phe Met Ile Ala Ala Thr Tyr Asn Phe 
            20                  25                  30          


Ala Val Leu Lys Leu Met Gly Arg Gly Thr Lys Phe 
        35                  40                  


<210>  485
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLP1

<400>  485
cacgaggccc tgaccggcac cgagaagctg atcgagacct acttcagcaa gaactaccag       60

gactacgagt acctgatcaa c                                                 81


<210>  486
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLP1 + TM1

<400>  486
tgcctggtgg gcgccccctt cgccagcctg gtggccaccg gcctgtgctt cttcggcgtg       60

gccctgttct gcggctgcgg ccacgaggcc ctgaccggca ccgagaagct gatcgagacc      120

tacttcagca agaactacca ggactacgag tacctgatca ac                         162


<210>  487
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLP2

<400>  487
gagggcttct acaccaccgg cgccgtgagg cagatcttcg gcgactacaa gaccaccatc       60

tgcggcaagg gcctgagcgc caccgtgacc ggcggccaga agggcagggg cagcaggggc      120

cagcaccagg cccacagcct ggagagggtg tgccactgcc tgggcaagtg gctgggccac      180

cccgacaag                                                              189


<210>  488
<211>  264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLP2 + TM2

<400>  488
gtgatccacg ccttccagta cgtgatctac ggcaccgcca gcttcttctt cctgtacggc       60

gccctgctgc tggccgaggg cttctacacc accggcgccg tgaggcagat cttcggcgac      120

tacaagacca ccatctgcgg caagggcctg agcgccaccg tgaccggcgg ccagaagggc      180

aggggcagca ggggccagca ccaggcccac agcctggaga gggtgtgcca ctgcctgggc      240

aagtggctgg gccaccccga caag                                             264


<210>  489
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLP3

<400>  489
ttcaacacct ggaccacctg ccagagcatc gccttcccca gcaagaccag cgccagcatc       60

ggcagcctgt gcgccgacgc caggatgtac ggcgtgctgc cctggaacgc cttccccggc      120

aaggtgtgcg gcagcaacct gctgagcatc tgcaagaccg ccgagttc                   168


<210>  490
<211>  240
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLP3 + TM3

<400>  490
ggcatcacct acgccctgac cgtggtgtgg ctgctggtgt tcgcctgcag cgccgtgccc       60

gtgtacatct acttcaacac ctggaccacc tgccagagca tcgccttccc cagcaagacc      120

agcgccagca tcggcagcct gtgcgccgac gccaggatgt acggcgtgct gccctggaac      180

gccttccccg gcaaggtgtg cggcagcaac ctgctgagca tctgcaagac cgccgagttc      240


<210>  491
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLP4

<400>  491
gccacctaca acttcgccgt gctgaagctg atgggcaggg gcaccaagtt c                51


<210>  492
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLP4 + TM4

<400>  492
cagatgacct tccacctgtt catcgccgcc ttcgtgggcg ccgccgccac cctggtgagc       60

ctgctgacct tcatgatcgc cgccacctac aacttcgccg tgctgaagct gatgggcagg      120

ggcaccaagt tc                                                          132


