                               SEQUENCE LISTING

<110> KLEO PHARMACEUTICALS, INC.
 
<120> DIRECTED CONJUGATION TECHNOLOGIES

<130> 2013064-0044

<140> PCT/US2020/061127
<141> 2020-11-18

<150> 63/063,902
<151> 2020-08-10

<150> 62/937,131
<151> 2019-11-18

<160> 85    

<170> PatentIn version 3.5

<210> 1
<211> 301
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
        115                 120                 125             


Val Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
                165                 170                 175     


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            180                 185                 190         


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        195                 200                 205             


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
225                 230                 235                 240 


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                245                 250                 255     


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Glu 
            260                 265                 270         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Leu Pro Glu Thr Gly Gly Ser His His His His His His 
    290                 295                 300     


<210> 2
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Ala Pro Ala Arg 
1               


<210> 3
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Arg Ala Pro Ala 
1               


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
His Trp Arg Gly Trp Ala 
1               5       


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Trp Gly Arg Arg 
1               


<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Arg Arg Gly Trp 
1               


<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Asn Lys Phe Arg Gly Lys Tyr Lys 
1               5               


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Asn Arg Phe Arg Gly Lys Tyr Lys 
1               5               


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Asn Ala Arg Lys Phe Tyr Lys 
1               5           


<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Asn Ala Arg Lys Phe Tyr Lys Gly 
1               5               


<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
His Trp Arg Gly Trp Val 
1               5       


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Lys His Phe Arg Asn Lys Asp 
1               5           


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Arg His Arg Phe Asn Lys Asp 
1               5           


<210> 14
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Arg Thr Tyr Lys 
1               


<210> 15
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Glu Leu Val Trp 
1               


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Glu Leu Val Trp 
1               5   


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ala Trp His Leu Gly Glu Leu Val Trp 
1               5                   


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ala Trp Asp Leu Gly Glu Leu Val Trp 
1               5                   


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 19
Ala Trp Xaa Leu Gly Glu Leu Val Trp 
1               5                   


<210> 20
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 20
Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 21
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 21
Asp Cys Ala Trp Xaa Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 22
Asp Cys Ala Trp Asp Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 23
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(15)
<223> May or may not form a disulfide bond 

<220>
<221> MISC_FEATURE
<222> (3)..(13)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 23
Cys Asp Cys Ala Trp Xaa Leu Gly Glu Leu Val Trp Cys Thr Cys 
1               5                   10                  15  


<210> 24
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(15)
<223> May or may not form a disulfide bond 

<220>
<221> MISC_FEATURE
<222> (3)..(13)
<223> May or may not form a disulfide bond

<400> 24
Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys 
1               5                   10                  15  


<210> 25
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(15)
<223> May or may not form a disulfide bond 

<220>
<221> MISC_FEATURE
<222> (3)..(13)
<223> May or may not form a disulfide bond

<400> 25
Cys Asp Cys Ala Trp Asp Leu Gly Glu Leu Val Trp Cys Thr Cys 
1               5                   10                  15  


<210> 26
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Phe Asn Met Gln Gln Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Lys Ile Lys Ser Ile Arg Asp 
            20                  25                  30          


Asp 
    


<210> 27
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 27
Phe Asn Met Gln Cys Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Lys Ile Lys Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 28
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 28
Arg Gly Asn Cys Ala Tyr His Arg Gly Gln Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


His 
    


<210> 29
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 29
Arg Gly Asn Cys Ala Tyr His Lys Gly Gln Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


His 
    


<210> 30
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 30
Arg Gly Asn Cys Lys Tyr His Arg Gly Gln Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


His 
    


<210> 31
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 31
Arg Gly Asn Cys Ala Trp His Arg Gly Lys Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


His 
    


<210> 32
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 32
Arg Gly Asn Cys Lys Trp His Arg Gly Glu Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


His 
    


<210> 33
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 33
Arg Gly Asn Cys Lys Trp His Arg Gly Gln Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


His 
    


<210> 34
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 34
Arg Gly Asn Cys Lys Tyr His Leu Gly Glu Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


His 
    


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 35
Arg Gly Asn Cys Lys Tyr His Leu Gly Gln Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


His 
    


<210> 36
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 36
Asp Cys Lys Trp His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 37
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 37
Asp Cys Lys Tyr His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 38
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 38
Asp Cys Lys Trp His Arg Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 39
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 39
Asp Cys Lys Trp His Leu Gly Gln Leu Val Trp Cys Thr 
1               5                   10              


<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 40
Asp Cys Lys Tyr His Arg Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 41
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 41
Asp Cys Lys Tyr His Leu Gly Gln Leu Val Trp Cys Thr 
1               5                   10              


<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 42
Asp Cys Lys Trp His Arg Gly Gln Leu Val Trp Cys Thr 
1               5                   10              


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<400> 43
Asp Cys Lys Tyr His Arg Gly Gln Leu Val Trp Cys Thr 
1               5                   10              


<210> 44
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 44
Phe Asn Lys Gln Cys Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 45
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 45
Phe Asn Met Gln Cys Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Lys Asp 
            20                  25                  30          


Asp Cys 
        


<210> 46
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 46
Phe Asn Met Gln Cys Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Lys Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 47
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 47
Phe Asn Met Gln Cys Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 48
Arg Gly Asn Cys Ala Trp His Leu Gly Gln Leu Val Trp Cys Lys Tyr 
1               5                   10                  15      


His 
    


<210> 49
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 49
Arg Gly Asn Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Lys Tyr 
1               5                   10                  15      


His 
    


<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 50
Arg Gly Asn Cys Ala Tyr His Leu Gly Gln Leu Val Trp Cys Thr Lys 
1               5                   10                  15      


His 
    


<210> 51
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 51
Arg Gly Asn Cys Ala Tyr His Leu Gly Gln Leu Val Trp Cys Thr Tyr 
1               5                   10                  15      


Lys 
    


<210> 52
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<400> 52
Arg Gly Asn Cys Ala Tyr His Arg Gly Gln Leu Val Trp Cys Thr Lys 
1               5                   10                  15      


His 
    


<210> 53
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 53
Lys Asn Met Gln Cys Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 54
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 54
Phe Asn Met Gln Cys Gln Lys Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 55
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 55
Phe Asn Met Gln Cys Gln Arg Arg Phe Tyr Glu Ala Lys His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 56
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 56
Phe Asn Met Gln Cys Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Lys Ala Arg Ile Arg Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 57
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 57
Phe Asn Met Gln Cys Lys Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210> 58
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (5)..(34)
<223> May or may not form a disulfide bond

<400> 58
Phe Asn Met Gln Cys Gln Arg Arg Phe Tyr Glu Ala Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Arg Ile Arg Ser Ile Arg Lys 
            20                  25                  30          


Asp Cys 
        


<210> 59
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(11)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(7)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 59
Cys Xaa Tyr His Xaa Xaa Xaa Leu Val Trp Cys 
1               5                   10      


<210> 60
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(8)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 60
Xaa Cys Xaa Tyr His Xaa Xaa Xaa Leu Val Trp Cys 
1               5                   10          


<210> 61
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(11)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 61
Cys Xaa Tyr His Xaa Xaa Xaa Leu Val Trp Cys Xaa 
1               5                   10          


<210> 62
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 62
Xaa Xaa Xaa Cys Xaa Tyr His Xaa Xaa Xaa Leu Val Trp Cys Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(15)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 63
Xaa Cys Xaa Tyr His Xaa Xaa Xaa Leu Val Trp Cys Xaa Xaa Xaa 
1               5                   10                  15  


<210> 64
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 64
Xaa Xaa Xaa Cys Xaa Tyr His Xaa Xaa Xaa Leu Val Trp Cys Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210> 65
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> Any amino acid

<220>
<221> MISC_FEATURE 
<222> (1)..(3)
<223> This region may encompass 1-3 residues

<220>
<221> MOD_RES
<222> (5)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<220>
<221> MISC_FEATURE 
<222> (15)..(17)
<223> This region may encompass 1-3 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 65
Xaa Xaa Xaa Cys Xaa Xaa His Xaa Gly Xaa Leu Val Trp Cys Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210> 66
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> Any amino acid

<220>
<221> MISC_FEATURE 
<222> (1)..(3)
<223> This region may encompass 1-3 residues

<220>
<221> MOD_RES
<222> (5)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 66
Xaa Xaa Xaa Cys Xaa Xaa His Xaa Gly Xaa Leu Val Trp Cys Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210> 67
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(15)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 67
Asp Cys Xaa Xaa His Xaa Gly Xaa Leu Val Trp Cys Xaa Xaa Xaa 
1               5                   10                  15  


<210> 68
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 68
Asp Cys Xaa Xaa His Xaa Gly Xaa Leu Val Trp Cys Thr 
1               5                   10              


<210> 69
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 69
Arg Gly Asn Cys Xaa Xaa His Xaa Gly Xaa Leu Val Trp Cys Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210> 70
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 70
Leu Pro Xaa Thr Gly 
1               5   


<210> 71
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MISC_FEATURE 
<222> (5)..(14)
<223> This region may encompass 1-10 residues

<400> 71
Leu Pro Xaa Thr Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  


<210> 72
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE 
<222> (5)..(14)
<223> This region may encompass 1-10 residues

<400> 72
Leu Pro Glu Thr Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  


<210> 73
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Gly Gly Gly Gly Gly 
1               5   


<210> 74
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Leu Pro Glu Thr Gly 
1               5   


<210> 75
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE 
<222> (1)..(10)
<223> This sequence may encompass 1-10 residues

<400> 75
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10  


<210> 76
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (6)..(15)
<223> Any amino acid

<220>
<221> MISC_FEATURE 
<222> (6)..(15)
<223> This region may encompass 1-10 residues

<400> 76
Leu Pro Xaa Thr Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210> 77
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(15)
<223> Any amino acid

<220>
<221> MISC_FEATURE 
<222> (6)..(15)
<223> This region may encompass 1-10 residues

<400> 77
Leu Pro Glu Thr Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210> 78
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE 
<222> (1)..(5)
<223> This sequence may encompass 3-5 residues

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 78
Gly Gly Gly Gly Gly 
1               5   


<210> 79
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(7)
<223> Any amino acid

<400> 79
Leu Pro Glu Thr Gly Xaa Xaa 
1               5           


<210> 80
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 80
Asp Cys Ala Trp His Leu Gly Glu Leu Xaa Trp Cys Thr 
1               5                   10              


<210> 81
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 81
Asp Cys Ala Trp His Xaa Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210> 82
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (2)..(12)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 82
Asp Cys Ala Trp His Leu Gly Xaa Leu Val Trp Cys Thr 
1               5                   10              


<210> 83
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (4)..(14)
<223> May or may not form a disulfide bond

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Lys or Arg

<400> 83
Gly Pro Asp Cys Ala Tyr His Xaa Gly Glu Leu Val Trp Cys Thr Phe 
1               5                   10                  15      


His 
    


<210> 84
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Leu Pro Glu Thr Gly Gly 
1               5       


<210> 85
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Leu Pro Glu Thr 
1               


