                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> CODON OPTIMIZED NEW GENERATION REGULATABLE FUSOGENIC ONCOLYTIC 
      HERPES SIMPLEX VIRUS TYPE 1 VIRUS AND METHODS OF USE

<130> 043214-096570WOPT

<140> PCT/US2020/060372
<141> 2020-11-13

<150> 62/936,776
<151> 2019-11-18

<160> 30    

<170> PatentIn version 3.5

<210> 1

<400> 1
000


<210> 2
<211> 338
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Leu Ala Val Arg Ser Leu Gln His Leu Ser Thr Val Val Leu Ile 
1               5                   10                  15      


Thr Ala Tyr Gly Leu Val Leu Val Trp Tyr Thr Val Phe Gly Ala Ser 
            20                  25                  30          


Pro Leu His Arg Cys Ile Tyr Ala Val Arg Pro Thr Gly Thr Asn Asn 
        35                  40                  45              


Asp Thr Ala Leu Val Trp Met Lys Met Asn Gln Thr Leu Leu Phe Leu 
    50                  55                  60                  


Gly Ala Pro Thr His Pro Pro Asn Gly Gly Trp Arg Asn His Ala His 
65                  70                  75                  80  


Ile Cys Tyr Ala Asn Leu Ile Ala Gly Arg Val Val Pro Phe Gln Val 
                85                  90                  95      


Pro Pro Asp Ala Thr Asn Arg Arg Ile Met Asn Val His Glu Ala Val 
            100                 105                 110         


Asn Cys Leu Glu Thr Leu Trp Tyr Thr Arg Val Arg Leu Val Val Val 
        115                 120                 125             


Gly Trp Phe Leu Tyr Leu Ala Phe Val Ala Leu His Gln Arg Arg Cys 
    130                 135                 140                 


Met Phe Gly Val Val Ser Pro Ala His Lys Met Val Ala Pro Ala Thr 
145                 150                 155                 160 


Tyr Leu Leu Asn Tyr Ala Gly Arg Ile Val Ser Ser Val Phe Leu Gln 
                165                 170                 175     


Tyr Pro Tyr Thr Lys Ile Thr Arg Leu Leu Cys Glu Leu Ser Val Gln 
            180                 185                 190         


Arg Gln Asn Leu Val Gln Leu Phe Glu Thr Asp Pro Val Thr Phe Leu 
        195                 200                 205             


Tyr His Arg Pro Ala Ile Gly Val Ile Val Gly Cys Glu Leu Met Leu 
    210                 215                 220                 


Arg Phe Val Ala Val Gly Leu Ile Val Gly Thr Ala Phe Ile Ser Arg 
225                 230                 235                 240 


Gly Ala Cys Ala Ile Thr Tyr Pro Leu Phe Leu Thr Ile Thr Thr Trp 
                245                 250                 255     


Cys Phe Val Ser Thr Ile Gly Leu Thr Glu Leu Tyr Cys Ile Leu Arg 
            260                 265                 270         


Arg Gly Pro Ala Pro Lys Asn Ala Asp Lys Ala Ala Ala Pro Gly Arg 
        275                 280                 285             


Ser Lys Gly Leu Ser Gly Val Cys Gly Arg Cys Cys Ser Ile Ile Leu 
    290                 295                 300                 


Ser Gly Ile Ala Met Arg Leu Cys Tyr Ile Ala Val Val Ala Gly Val 
305                 310                 315                 320 


Val Leu Val Ala Leu His Tyr Glu Gln Glu Ile Gln Arg Arg Leu Phe 
                325                 330                 335     


Asp Val 
        


<210> 3
<211> 1737
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      IL10R sequence

<400> 3
atgctgccgt gcctcgtagt gctgctggcg gcgctcctca gcctccgtct tggctcagac       60

gctcatggga cagagctgcc cagccctccg tctgtgtggt ttgaagcaga atttttccac      120

cacatcctcc actggacacc catcccaaat cagtctgaaa gtacctgcta tgaagtggcg      180

ctcctgaggt atggaataga gtcctggaac tccatctcca actgtagcca gaccctgtcc      240

tatgacctta ccgcagtgac cttggacctg taccacagca atggctaccg ggccagagtg      300

cgggctgtgg acggcagccg gcactccaac tggaccgtca ccaacacccg cttctctgtg      360

gatgaagtga ctctgacagt tggcagtgtg aacctagaga tccacaatgg cttcatcctc      420

gggaagattc agctacccag gcccaagatg gcccccgcaa atgacacata tgaaagcatc      480

ttcagtcact tccgagagta tgagattgcc attcgcaagg tgccgggaaa cttcacgttc      540

acacacaaga aagtaaaaca tgaaaacttc agcctcctaa cctctggaga agtgggagag      600

ttctgtgtcc aggtgaaacc atctgtcgct tcccgaagta acaaggggat gtggtctaaa      660

gaggagtgca tctccctcac caggcagtat ttcaccgtga ccaacgtcat catcttcttt      720

gcctttgtcc tgctgctctc cggagccctc gcctactgcc tggccctcca gctgtatgtg      780

cggcgccgaa agaagctacc cagtgtcctg ctcttcaaga agcccagccc cttcatcttc      840

atcagccagc gtccctcccc agagacccaa gacaccatcc acccgcttga tgaggaggcc      900

tttttgaagg tgtccccaga gctgaagaac ttggacctgc acggcagcac agacagtggc      960

tttggcagca ccaagccatc cctgcagact gaagagcccc agttcctcct ccctgaccct     1020

cacccccagg ctgacagaac gctgggaaac agggagcccc ctgtgctggg ggacagctgc     1080

agtagtggca gcagcaatag cacagacagc gggatctgcc tgcaggagcc cagcctgagc     1140

cccagcacag ggcccacctg ggagcaacag gtggggagca acagcagggg ccaggatgac     1200

agtggcattg acttagttca aaactctgag ggccgggctg gggacacaca gggtggctcg     1260

gccttgggcc accacagtcc cccggagcct gaggtgcctg gggaagaaga cccagctgct     1320

gtggcattcc agggttacct gaggcagacc agatgtgctg aagagaaggc aaccaagaca     1380

ggctgcctgg aggaagaatc gcccttgaca gatggccttg gccccaaatt cgggagatgc     1440

ctggttgatg aggcaggctt gcatccacca gccctggcca agggctattt gaaacaggat     1500

cctctagaaa tgactctggc ttcctcaggg gccccaacgg gacagtggaa ccagcccact     1560

gaggaatggt cactcctggc cttgagcagc tgcagtgacc tgggaatatc tgactggagc     1620

tttgcccatg accttgcccc tctaggctgt gtggcagccc caggtggtct cctgggcagc     1680

tttaactcag acctggtcac cctgcccctc atctctagcc tgcagtcaag tgagtga        1737


<210> 4
<211> 1788
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      TGFBRII sequence

<400> 4
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggatgtgg aaatggaggc ccagaaagat      120

gaaatcatct gccccagctg taataggact gcccatccac tgagacatat taataacgac      180

atgatagtca ctgacaacaa cggtgcagtc aagtttccac aactgtgtaa attttgtgat      240

gtgagatttt ccacctgtga caaccagaaa tcctgcatga gcaactgcag catcacctcc      300

atctgtgaga agccacagga agtctgtgtg gctgtatgga gaaagaatga cgagaacata      360

acactagaga cagtttgcca tgaccccaag ctcccctacc atgactttat tctggaagat      420

gctgcttctc caaagtgcat tatgaaggaa aaaaaaaagc ctggtgagac tttcttcatg      480

tgttcctgta gctctgatga gtgcaatgac aacatcatct tctcagaaga atataacacc      540

agcaatcctg acttgttgct agtcatattt caagtgacag gcatcagcct cctgccacca      600

ctgggagttg ccatatctgt catcatcatc ttctactgct accgcgttaa ccggcagcag      660

aagctgagtt caacctggga aaccggcaag acgcggaagc tcatggagtt cagcgagcac      720

tgtgccatca tcctggaaga tgaccgctct gacatcagct ccacgtgtgc caacaacatc      780

aaccacaaca cagagctgct gcccattgag ctggacaccc tggtggggaa aggtcgcttt      840

gctgaggtct ataaggccaa gctgaagcag aacacttcag agcagtttga gacagtggca      900

gtcaagatct ttccctatga ggagtatgcc tcttggaaga cagagaagga catcttctca      960

gacatcaatc tgaagcatga gaacatactc cagttcctga cggctgagga gcggaagacg     1020

gagttgggga aacaatactg gctgatcacc gccttccacg ccaagggcaa cctacaggag     1080

tacctgacgc ggcatgtcat cagctgggag gacctgcgca agctgggcag ctccctcgcc     1140

cgggggattg ctcacctcca cagtgatcac actccatgtg ggaggcccaa gatgcccatc     1200

gtgcacaggg acctcaagag ctccaatatc ctcgtgaaga acgacctaac ctgctgcctg     1260

tgtgactttg ggctttccct gcgtctggac cctactctgt ctgtggatga cctggctaac     1320

agtgggcagg tgggaactgc aagatacatg gctccagaag tcctagaatc caggatgaat     1380

ttggagaatg ttgagtcctt caagcagacc gatgtctact ccatggctct ggtgctctgg     1440

gaaatgacat ctcgctgtaa tgcagtggga gaagtaaaag attatgagcc tccatttggt     1500

tccaaggtgc gggagcaccc ctgtgtcgaa agcatgaagg acaacgtgtt gagagatcga     1560

gggcgaccag aaattcccag cttctggctc aaccaccagg gcatccagat ggtgtgtgag     1620

acgttgactg agtgctggga ccacgaccca gaggcccgtc tcacagccca gtgtgtggca     1680

gaacgcttca gtgagctgga gcatctggac aggctctcgg ggaggagctg ctcggaggag     1740

aagattcctg aagacggctc cctaaacact accaaatagc tcttctgg                  1788


<210> 5
<211> 465
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      IL-2 sequence

<400> 5
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt gataa                      465


<210> 6
<211> 763
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      IL-12a sequence

<400> 6
aatgtggccc cctgggtcag cctcccagcc accgccctca cctgccgcgg ccacaggtct       60

gcatccagcg gctcgccctg tgtccctgca gtgccggctc agcatgtgtc cagcgcgcag      120

cctcctcctt gtggctaccc tggtcctcct ggaccacctc agtttggcca gaaacctccc      180

cgtggccact ccagacccag gaatgttccc atgccttcac cactcccaaa acctgctgag      240

ggccgtcagc aacatgctcc agaaggccag acaaactcta gaattttacc cttgcacttc      300

tgaagagatt gatcatgaag atatcacaaa agataaaacc agcacagtgg aggcctgttt      360

accattggaa ttaaccaaga atgagagttg cctaaattcc agagagacct ctttcataac      420

taatgggagt tgcctggcct ccagaaagac ctcttttatg atggccctgt gccttagtag      480

tatttatgaa gacttgaaga tgtaccaggt ggagttcaag accatgaatg caaagcttct      540

gatggatcct aagaggcaga tctttctaga tcaaaacatg ctggcagtta ttgatgagct      600

gatgcaggcc ctgaatttca acagtgagac tgtgccacaa aaatcctccc ttgaagaacc      660

ggatttttat aaaactaaaa tcaagctctg catacttctt catgctttca gaattcgggc      720

agtgactatt gatagagtga tgagctatct gaatgcttcc taa                        763


<210> 7
<211> 489
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      IL-15 sequence

<400> 7
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tccctatcag tgatagaga                                                    19


<210> 9

<400> 9
000


<210> 10
<211> 282
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atggccctgg acgccgccta ctgcttccgc aacgtgcagg acaactgctg cctgcgcccc       60

ctgtacatcg acttccgcaa ggacctgggc tggaagtgga tccacgagcc caagggctac      120

aacgccaact tctgcgccgg cgcctgcccc taccgcgcca gcaagagccc cagctgcgtg      180

agccaggacc tggagcccct gaccatcgtg tactacgtgg gccgcaagcc caaggtggag      240

cagctgagca acatgatcgt gaagagctgc aagtgcagct aa                         282


<210> 11
<211> 92
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Arg Ala Ser Lys Ser Pro Ser Cys Val Ser Gln Asp Leu Glu 
    50                  55                  60                  


Pro Leu Thr Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val Glu Gln 
65                  70                  75                  80  


Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                85                  90          


<210> 12
<211> 2730
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
tcccattaca accagctcgt cgccggccac gccgcgcccc aaccccagcc gcattccgcg       60

tttggtttcc cggctgcggc gggggccgtg gcctatgggc ctcacggcgc gggtctttcc      120

cagcattacc ctccccacgt cgcccatcag tatcccgggg tgctgttctc gggacccagc      180

ccactcgagg cgcagatagc cgcgttggtg ggggccatag ccgcggaccg ccaggcgggc      240

ggtcagccgg ccgcgggaga ccctggggtc cgggggtcgg gaaagcgtcg ccggtacgag      300

gcggggccgt cggagtccta ctgcgaccag gacgaaccgg acgcggacta cccgtactac      360

cccggggagg ctcgaggcgg gccgcgcggg gtcgactctc ggcgcgcggc ccgccagtct      420

cccgggacca acgagaccat cacggcgctg atgggggcgg tgacgtctct gcagcaggaa      480

ctggcgcaca tgcgggctcg gaccagcgcc ccctatggaa tgtacacgcc ggtggcgcac      540

tatcgccctc aggtggggga gccggaacca acaacgaccc acccggccct ttgtcccccg      600

gaggccgtgt atcgcccccc accacacagc gccccctacg gtcctcccca gggtccggcg      660

tcccatgccc ccactccccc gtatgcccca gctgcctgcc cgccaggccc gccaccgccc      720

ccatgtcctt ccacccagac gcgcgcccct ctaccgacgg agcccgcgtt cccccccgcc      780

gccaccggat cccaaccgga ggcatccaac gcggaggccg gggcccttgt caacgccagc      840

agcgcagcac acgtggacgt tgacacggcc cgcgccgccg atttgttcgt ctctcagatg      900

atgggggccc gctgattcgc cccggtcttt ggtaccatgg gatgtcttac tgtatatctt      960

tttaaataaa ccaggtaata ccaaataaga cccattggtg tatgttcttt ttttattggc     1020

gcgccatatg cattcccgct tatgctaatg agatgcgttc ggacggcccc tcgctccccg     1080

cgtaattact ccctcggggt tccgggttat gctgattact ttcttggcag aacacgcaga     1140

gcctcgcgcg ccgccgggtg ggtgggctga tcggccccta ttggtcccct gggcttccta     1200

gtatgctaat gatattctcc ccgggggcgg gcaccactca gggccgcgcc ggcggggcgc     1260

cggggggact cccatctgcg tcggcggggg gcggcgcatg ctaatgatat tcttggagta     1320

cacccggttg gtccccgggg acggggccgc cccgagaggg ggggattccc tccctccgcc     1380

cccgccgggg cgcgcggcta ttgggggaat cgtaaatgcc gcccctttgg gggagtggat     1440

aggcgccggg tatataagca gagctctccc tatcagtgat agagatctcc ctatcagtga     1500

tagagatcgt cgacgagctc gcgaagctta ccggtcgata tctatcgcga gctcgccaat     1560

tgcgagatct agaagcggaa ttctgcccgt cagaacttgt ttattgcagc ttataatggt     1620

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     1680

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggttacc caaaaggcgt     1740

accaaacaaa aaaaccaaaa gatgcgcatg cggtttaaca cccgtggttt ttatttacaa     1800

caaacccccc gtcacaggtc gtcctcgtcg gcgtcaccgt ctttgttggg aacttgggtg     1860

tagttggtgt tgcggcgctt gcgcatgacc atgtcggtga ccttggcgct gagcagcgcg     1920

ctcgtgccct tcttcttggc cttgtgttcc gtgcgctcca tggccgacac cagggccatg     1980

taccgtatca tctccctggc ctcggctagc ttggcctcgt caaagtcgcc gccctcctcg     2040

ccctccccgg acgcgtccgg gttggtgggg ttcttgagct ccttggtggt tagagggtac     2100

agggccttca tggggttgct ctgcagccgc atgacgtaac gaaaggcgaa gaaggccgcc     2160

gccaggccgg ccaggaccaa cagacccacg gccagcgccc caaaggggtt ggacatgaag     2220

gaggacacgc ccgacacggc cgataccacg ccgcccacga tgcccatcac caccttgccg     2280

accgcgcgcc ccaggtcgcc catcccctcg aagaacgcgc ccaggcccgc gaacatggcg     2340

gcgttggcgt cggcgtggat gaccgtgtcg atgtcggcga agcgcaggtc gtgcagctgg     2400

ttgcggcgct ggacctccgt gtagtccagc aggccgctgt ccttgatctc gtggcgggtg     2460

tacacctcca gggggacaaa ctcgtgatcc tccagcatgg tgatgttgag gtcgatgaag     2520

gtgctgacgg tggtgatgtc ggcgcggctc agctggtggg agtacgcgta ctcctcgaag     2580

tacacgtagc ccccaccgaa ggtgaagtag cgccggtgtc ccacggtgca cggctcgatc     2640

gcatcgcgcg tcagccgcag ctcgttgttc tcccccagct gcccctcgac caacgggccc     2700

tggtcttcgt accgaaagct gaccaggggg                                      2730


<210> 13
<211> 1000
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
tcccattaca accagctcgt cgccggccac gccgcgcccc aaccccagcc gcattccgcg       60

tttggtttcc cggctgcggc gggggccgtg gcctatgggc ctcacggcgc gggtctttcc      120

cagcattacc ctccccacgt cgcccatcag tatcccgggg tgctgttctc gggacccagc      180

ccactcgagg cgcagatagc cgcgttggtg ggggccatag ccgcggaccg ccaggcgggc      240

ggtcagccgg ccgcgggaga ccctggggtc cgggggtcgg gaaagcgtcg ccggtacgag      300

gcggggccgt cggagtccta ctgcgaccag gacgaaccgg acgcggacta cccgtactac      360

cccggggagg ctcgaggcgg gccgcgcggg gtcgactctc ggcgcgcggc ccgccagtct      420

cccgggacca acgagaccat cacggcgctg atgggggcgg tgacgtctct gcagcaggaa      480

ctggcgcaca tgcgggctcg gaccagcgcc ccctatggaa tgtacacgcc ggtggcgcac      540

tatcgccctc aggtggggga gccggaacca acaacgaccc acccggccct ttgtcccccg      600

gaggccgtgt atcgcccccc accacacagc gccccctacg gtcctcccca gggtccggcg      660

tcccatgccc ccactccccc gtatgcccca gctgcctgcc cgccaggccc gccaccgccc      720

ccatgtcctt ccacccagac gcgcgcccct ctaccgacgg agcccgcgtt cccccccgcc      780

gccaccggat cccaaccgga ggcatccaac gcggaggccg gggcccttgt caacgccagc      840

agcgcagcac acgtggacgt tgacacggcc cgcgccgccg atttgttcgt ctctcagatg      900

atgggggccc gctgattcgc cccggtcttt ggtaccatgg gatgtcttac tgtatatctt      960

tttaaataaa ccaggtaata ccaaataaga cccattggtg                           1000


<210> 14
<211> 1000
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
caaaaggcgt accaaacaaa aaaaccaaaa gatgcgcatg cggtttaaca cccgtggttt       60

ttatttacaa caaacccccc gtcacaggtc gtcctcgtcg gcgtcaccgt ctttgttggg      120

aacttgggtg tagttggtgt tgcggcgctt gcgcatgacc atgtcggtga ccttggcgct      180

gagcagcgcg ctcgtgccct tcttcttggc cttgtgttcc gtgcgctcca tggccgacac      240

cagggccatg taccgtatca tctccctggc ctcggctagc ttggcctcgt caaagtcgcc      300

gccctcctcg ccctccccgg acgcgtccgg gttggtgggg ttcttgagct ccttggtggt      360

tagagggtac agggccttca tggggttgct ctgcagccgc atgacgtaac gaaaggcgaa      420

gaaggccgcc gccaggccgg ccaggaccaa cagacccacg gccagcgccc caaaggggtt      480

ggacatgaag gaggacacgc ccgacacggc cgataccacg ccgcccacga tgcccatcac      540

caccttgccg accgcgcgcc ccaggtcgcc catcccctcg aagaacgcgc ccaggcccgc      600

gaacatggcg gcgttggcgt cggcgtggat gaccgtgtcg atgtcggcga agcgcaggtc      660

gtgcagctgg ttgcggcgct ggacctccgt gtagtccagc aggccgctgt ccttgatctc      720

gtggcgggtg tacacctcca gggggacaaa ctcgtgatcc tccagcatgg tgatgttgag      780

gtcgatgaag gtgctgacgg tggtgatgtc ggcgcggctc agctggtggg agtacgcgta      840

ctcctcgaag tacacgtagc ccccaccgaa ggtgaagtag cgccggtgtc ccacggtgca      900

cggctcgatc gcatcgcgcg tcagccgcag ctcgttgttc tcccccagct gcccctcgac      960

caacgggccc tggtcttcgt accgaaagct gaccaggggg                           1000


<210> 15
<211> 694
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
cattcccgct tatgctaatg agatgcgttc ggacggcccc tcgctccccg cgtaattact       60

ccctcggggt tccgggttat gctgattact ttcttggcag aacacgcaga gcctcgcgcg      120

ccgccgggtg ggtgggctga tcggccccta ttggtcccct gggcttccta gtatgctaat      180

gatattctcc ccgggggcgg gcaccactca gggccgcgcc ggcggggcgc cggggggact      240

cccatctgcg tcggcggggg gcggcgcatg ctaatgatat tcttggagta cacccggttg      300

gtccccgggg acggggccgc cccgagaggg ggggattccc tccctccgcc cccgccgggg      360

cgcgcggcta ttgggggaat cgtaaatgcc gcccctttgg gggagtggat aggcgccggg      420

tatataagca gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt      480

cgacgagctc gcgaagctta ccggtcgata tctatcgcga gctcgccaat tgcgagatct      540

agaagcggaa ttctgcccgt cagaacttgt ttattgcagc ttataatggt tacaaataaa      600

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt      660

tgtccaaact catcaatgta tcttatcatg tctg                                  694


<210> 16
<211> 134
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
cagaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc       60

acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta      120

tcttatcatg tctg                                                        134


<210> 17
<211> 806
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
ggcgcgccgg gccggcgggg gccaacggga gcgcggggcc ggcatctcat taccacgaac       60

ccggaagggc aggggagcga gcccgcccgc gacgagggtc tcattagcat cgcgggcgga      120

agcggaagcc gcccgcgccg ggcgctaatg agatgccgcg cgggcggagc ggcggcggcg      180

cgaccaacgg gccgccgcca cggacgcgga cgcgcgggcg tcggggcggg gccgcgcata      240

atgcggttcc acctgggggc ggaaccccgg cgagccgggg cgcggcggcg tcgatcgctc      300

ctcctccgcg tcctcctcct ttccccccgc cccgcgcgcc ccgaggacta tatgagccga      360

gctctcccta tcagtgatag agatctccct atcagtgata gagatcgagc tcgcgtgtgc      420

atcgcgtatc acccaagctt gccaccatgg gcggcgccgc cgcccgcctg ggcgccgtga      480

tcctgttcgt ggtgatcgtg ggcctgcacg gcgtgcgcgg cgccctggac gccgcctact      540

gcttccgcaa cgtgcaggac aactgctgcc tgcgccccct gtacatcgac ttccgcaagg      600

acctgggctg gaagtggatc cacgagccca agggctacaa cgccaacttc tgcgccggcg      660

cctgccccta ccgcgccagc aagagcccca gctgcgtgag ccaggacctg gagcccctga      720

ccatcgtgta ctacgtgggc cgcaagccca aggtggagca gctgagcaac atgatcgtga      780

agagctgcaa gtgcagctaa gaattc                                           806


<210> 18
<211> 440
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
ggcgcgccgg gccggcgggg gccaacggga gcgcggggcc ggcatctcat taccacgaac       60

ccggaagggc aggggagcga gcccgcccgc gacgagggtc tcattagcat cgcgggcgga      120

agcggaagcc gcccgcgccg ggcgctaatg agatgccgcg cgggcggagc ggcggcggcg      180

cgaccaacgg gccgccgcca cggacgcgga cgcgcgggcg tcggggcggg gccgcgcata      240

atgcggttcc acctgggggc ggaaccccgg cgagccgggg cgcggcggcg tcgatcgctc      300

ctcctccgcg tcctcctcct ttccccccgc cccgcgcgcc ccgaggacta tatgagccga      360

gctctcccta tcagtgatag agatctccct atcagtgata gagatcgagc tcgcgtgtgc      420

atcgcgtatc acccaagctt                                                  440


<210> 19
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
gccaccatgg gcggcgccgc cgcccgcctg ggcgccgtga tcctgttcgt ggtgatcgtg       60

ggcctgcacg gcgtgcgcgg cgccctggac gccgcctact gcttccgcaa cgtgcaggac      120

aactgctgcc tgcgccccct gtacatcgac ttccgcaagg acctgggctg gaagtggatc      180

cacgagccca agggctacaa cgccaacttc tgcgccggcg cctgccccta ccgcgccagc      240

aagagcccca gctgcgtgag ccaggacctg gagcccctga ccatcgtgta ctacgtgggc      300

cgcaagccca aggtggagca gctgagcaac atgatcgtga agagctgcaa gtgcagctaa      360

gaattc                                                                 366


<210> 20
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
atgggcggcg ccgccgcccg cctgggcgcc gtgatcctgt tcgtggtgat cgtgggcctg       60

cacggcgtgc gcggc                                                        75


<210> 21
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 22
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 23
<211> 547
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Ser Ala Leu Asp Ala Ala Tyr Cys Phe Arg 
    450                 455                 460                 


Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile Asp Phe Arg 
465                 470                 475                 480 


Lys Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr Asn Ala 
                485                 490                 495     


Asn Phe Cys Ala Gly Ala Cys Pro Tyr Arg Ala Ser Lys Ser Pro Ser 
            500                 505                 510         


Cys Val Ser Gln Asp Leu Glu Pro Leu Thr Ile Val Tyr Tyr Val Gly 
        515                 520                 525             


Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys 
    530                 535                 540                 


Lys Cys Ser 
545         


<210> 24
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210> 25
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 26
<211> 546
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly 
        435                 440                 445             


Gly Gly Gly Gly Gly Ser Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn 
    450                 455                 460                 


Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile Asp Phe Arg Lys 
465                 470                 475                 480 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr Asn Ala Asn 
                485                 490                 495     


Phe Cys Ala Gly Ala Cys Pro Tyr Arg Ala Ser Lys Ser Pro Ser Cys 
            500                 505                 510         


Val Ser Gln Asp Leu Glu Pro Leu Thr Ile Val Tyr Tyr Val Gly Arg 
        515                 520                 525             


Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys 
    530                 535                 540                 


Cys Ser 
545     


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gly Gly Gly Gly Ser 
1               5   


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gly Gly Gly Gly Gly Ser 
1               5       


<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Arg Gly Asp Ser 
1               


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Gly Gly Gly Gly Gly Gly Ser 
1               5           


