                         SEQUENCE LISTING

<110>  Enthera S.r.l.
 
<120>  IGFBP3 ANTIBODIES AND THERAPEUTIC USES THEREOF

<130>  PCT 145204

<150>  EP19210646.6
<151>  2019-11-21

<150>  EP20167464.5
<151>  2020-04-01

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3

Ala Arg Gly Gly Glu Tyr Phe Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Gly Tyr Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5

Ile Asn Thr Tyr Asn Gly Asn Thr 
1               5               


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Ala Arg Asp Arg Gly Tyr Ser Ser Ser Pro Tyr Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Ile Asn Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9

Gly Gly Ser Ile Ser Thr Tyr Tyr 
1               5               


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11

Ala Arg Tyr Asp Ile Val Thr Gly Tyr Pro His Tyr Tyr Tyr Tyr Val 
1               5                   10                  15      


Met Asp Val 
            


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12

Gln Ser Val Ser Ser Ser Ser 
1               5           


<210>  13
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13

Gly Ala Ser 
1           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14

Gln Gln Asp Tyr Asn Leu Pro Leu Thr 
1               5                   


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Gln Ser Val Ser Ser Ser His 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16

Gln Gln Asp Tyr Asn Leu Thr Ile Thr 
1               5                   


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  18
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18

Ala Ala Ser 
1           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19

Gln Gln Tyr Asn Ser Tyr Pro Phe Thr 
1               5                   


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20

Gln Gly Ile Ser Ser Ala 
1               5       


<210>  21
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21

Asp Ala Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22

Gln Gln Phe Asn Asn Tyr Pro Ser Thr 
1               5                   


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23

Gln Gly Ile Arg Asn Asp 
1               5       


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24

Leu Gln His Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25

Gln Gly Ile Arg Asn Ala 
1               5       


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26

Leu Gln Asp Tyr Asn Tyr Pro Leu Thr 
1               5                   


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27

Arg Gly Ile Arg Asn Ala 
1               5       


<210>  28
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Asn Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Tyr Phe Tyr Tyr Tyr Gly Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Arg Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Tyr Ser Ser Ser Pro Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  30
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Arg Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Tyr Ser Ser Ser Pro Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  31
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Arg Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Tyr Ser Ser Ser Pro Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  32
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Asn Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Tyr Phe Tyr Tyr Tyr Gly Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  33
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Arg Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Tyr Ser Ser Ser Pro Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Asn Tyr Val Val Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Glu Tyr Phe Tyr Tyr Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Val Thr Tyr Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Tyr Ser Ser Ser Pro Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  36
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Ile Val Thr Gly Tyr Pro His Tyr Tyr Tyr Tyr Val Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ser Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  38
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


His Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Thr 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  39
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ser Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Ser 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  43
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Ala 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Gly Ile Arg Asn Ala 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  46
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaaaactat      180

gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagaggaggg      300

gagtacttct actattacgg tttggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  47
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta caccttttcc aattatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacactt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accactgaca catccacgag cacagcctac      240

atggcgctga ggggcctgag atctgacgac acggccgtgt attattgtgc gagagatagg      300

gggtatagca gcagccctta ctactactac tacggaatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  48
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta caccttttcc aattatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacactt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accactgaca catccacgag cacagcctac      240

atggcgctga ggggcctgag atctgacgac acggccgtgt attattgtgc gagagatagg      300

gggtatagca gcagccctta ctactactac tacggaatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  49
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta caccttttcc aattatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacactt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accactgaca catccacgag cacagcctac      240

atggcgctga ggggcctgag atctgacgac acggccgtgt attattgtgc gagagatagg      300

gggtatagca gcagccctta ctactactac tacggaatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  50
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaaaactat      180

gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagaggaggg      300

gagtacttct actattacgg tttggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  51
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta caccttttcc aattatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacactt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accactgaca catccacgag cacagcctac      240

atggcgctga ggggcctgag atctgacgac acggccgtgt attattgtgc gagagatagg      300

gggtatagca gcagccctta ctactactac tacggaatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  52
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaaaactat      180

gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagaggaggg      300

gagtacttct actattacgg tttggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  53
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc aactatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacgctt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagtca catacacgag tacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatagg      300

gggtatagca gcagccctta ttactactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210>  54
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt acttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtttatt actgtgcgag gtacgatatt      300

gtgactggtt atcctcacta ctactactac gttatggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  55
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
gaaattgtaa tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctcct tatcctggta ccagcagaaa      120

cctgggcagg ctcccaggct cctcatctat ggtgcatcca ccagggccac tggcatccca      180

gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctgcag      240

cctgaagatt ttgcagttta ttactgtcag caggattata acttaccgct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  56
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56
gaaattgtaa tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagccatt tatcctggta ccagcagaaa      120

cctgggcagg ctcccaggct cctcatctat ggtgcatcca ccagggccac tggcatccca      180

gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctgcag      240

cctgaagatt ttgcagttta ttattgtcag caggattata atttaacgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  57
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
gaaattgtaa tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctcct tatcctggta ccagcagaaa      120

cctgggcagg ctcccaggct cctcatctat ggtgcatcca ccagggccac tggcatccca      180

gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctgcag      240

cctgaagatt ttgcagttta ttactgtcag caggattata acttaccgct cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  58
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctataggaga cagagtcacc       60

atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca      120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  59
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaggtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaagatcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc ggggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaataatt accctagcac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  60
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  61
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctataggaga cagagtcacc       60

atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca      120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  62
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga caaagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgctttag gctggtatca gcagaaacca      120

ggaacagccc ctaaactcct gatctatgct gcatccagtt tacagagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattctg caacttatta ctgtctacaa gattacaatt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  63
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtcg gggcattaga aatgctttag gctggtatca gcagaaacca      120

ggaacagccc ctaaactcct gatctatgct gcatccagtt tacagagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattctg caacttatta ctgtctacaa gattacaatt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  64
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  65
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  66
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  67
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  68

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  69
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  69

Thr His Arg Thr Gly Leu Arg Ser Pro Asp Ile Pro Gln Asp Trp Val 
1               5                   10                  15      


Ser Phe Leu Arg Ser Phe Gly Gln Leu Thr Leu Cys Pro Arg Asn Gly 
            20                  25                  30          


Thr Val Thr Gly Lys Trp Arg Gly Ser His Val Val Gly Leu Leu Thr 
        35                  40                  45              


Thr Leu Asn Phe Gly Asp Gly Pro Asp Arg Asn Lys Thr Arg Thr Phe 
    50                  55                  60                  


Gln Ala Thr Val Leu Gly Ser Gln Met Gly Leu Lys Gly Ser Ser Ala 
65                  70                  75                  80  


Gly Gln Leu Val Leu Ile Thr Ala Arg Val Thr Thr Glu Arg Thr Ala 
                85                  90                  95      


Gly Thr Cys Leu Tyr Phe Ser Ala Val Pro Gly Ile Leu Pro Ser Ser 
            100                 105                 110         


Gln Pro Pro Ile Ser Cys Ser Glu Glu Gly Ala Gly Asn Ala Thr Leu 
        115                 120                 125             


Ser Pro Arg Met Gly Glu Glu Cys Val Ser Val Trp Ser His Glu Gly 
    130                 135                 140                 


Leu Val Leu Thr Lys Leu Leu Thr Ser Glu Glu Leu Ala Leu Cys Gly 
145                 150                 155                 160 


Ser Arg 
        


<210>  70
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  70

Thr His Thr Thr Gly Leu Arg Ser Pro Asp Ile Pro Gln Asp Trp Val 
1               5                   10                  15      


Ser Phe Leu Arg Ser Phe Gly Gln Leu Ser Leu Cys Pro Met Asn Glu 
            20                  25                  30          


Thr Val Thr Gly Thr Trp Gln Gly Pro His Val Val Gly Leu Leu Thr 
        35                  40                  45              


Thr Leu Asn Phe Gly Asp Gly Pro Asp Arg Asn Lys Thr Gln Thr Phe 
    50                  55                  60                  


Gln Ala Lys Ile His Gly Ser Gln Ile Gly Leu Thr Gly Ser Ser Ala 
65                  70                  75                  80  


Gly Glu Ser Val Leu Val Thr Ala Arg Val Ala Ser Gly Arg Thr Pro 
                85                  90                  95      


Gly Thr Cys Leu Tyr Phe Ser Gly Val Pro Lys Val Leu Pro Ser Ser 
            100                 105                 110         


Gln Pro Pro Ile Ser Cys Ser Glu Glu Gly Val Gly Asn Ala Thr Leu 
        115                 120                 125             


Ser Pro Val Met Gly Glu Glu Cys Val Arg Val Trp Ser His Glu Arg 
    130                 135                 140                 


Leu Val Leu Thr Glu Leu Leu Thr Ser Glu Glu Leu Ala Leu Cys Gly 
145                 150                 155                 160 


Ser 
    


<210>  71
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  71

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  72
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  72

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser 
            20                  25                  30  


<210>  73
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  73

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
            20                  25                  


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  74

Gly Gly Ser Ile Ser Thr Tyr 
1               5           


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  75

Gly Gly Ser Ile Ser Thr Tyr Tyr Trp Ser 
1               5                   10  


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  76

Thr Tyr Tyr Trp Ser 
1               5   


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  77

Ser Thr Tyr Tyr Trp Ser 
1               5       


<210>  78
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  78

Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Tyr Ile 
            


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  79

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  80

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
1               5                   10      


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  81

Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  82

Tyr Tyr Ser Gly Ser 
1               5   


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  83

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn 
1               5                   


<210>  84
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  84

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  85

Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn 
1               5                   10          


<210>  86
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  86

Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  87
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  87

Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
1               5                   10                  15      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Arg 
        35                  


<210>  88
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  88

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  89
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  89

Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser 
1               5                   10                  15      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  90
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  90

Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  91

Tyr Asp Ile Val Thr Gly Tyr Pro His Tyr Tyr Tyr Tyr Val Met Asp 
1               5                   10                  15      


Val 
    


<210>  92
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  92

Ala Arg Tyr Asp Ile Val Thr Gly Tyr Pro His Tyr Tyr Tyr Tyr Val 
1               5                   10                  15      


Met Asp 
        


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  93

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  94

Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10          


<210>  95
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  95

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  96
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  96

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Gly Ile 
            20                  25                  


<210>  97
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  97

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  98

Arg Ala Ser Arg Gly Ile Arg Asn Ala Leu Gly 
1               5                   10      


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  99

Arg Asn Ala Leu Gly Trp Tyr 
1               5           


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  100

Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  101

Gln Gln Lys Pro Gly Thr Ala Pro Lys 
1               5                   


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  102

Leu Gly Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  103

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  104

Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
1               5                   10  


<210>  105
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  105

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  106
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  106

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
1               5                   10                  15      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr 
            20                  25                  30          


Cys 
    


<210>  107
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  107

Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser 
            20                  25                  30          


Ala Thr Tyr Tyr Cys 
        35          


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  108

Leu Gln Asp Tyr Asn Tyr Pro Leu 
1               5               


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  109

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  110

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


