                         SEQUENCE LISTING

<110>  Bavarian Nordic A/S
 
<120>  Medical Uses of 4-1BBL Adjuvanted Recombinant Modified Vaccinia 
       Virus Ankara (MVA)

<130>  BNIT0016PCT

<150>  EP 20191226.8
<151>  2020-08-14

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  2
<211>  792
<212>  DNA
<213>  Homo sapiens

<400>  2
atgatcgaga catacaacca gacaagccct agaagcgccg ccacaggact gcctatcagc       60

atgaagatct tcatgtacct gctgaccgtg ttcctgatca cccagatgat cggcagcgcc      120

ctgtttgccg tgtacctgca cagacggctg gacaagatcg aggacgagag aaacctgcac      180

gaggacttcg tgttcatgaa gaccatccag cggtgcaaca ccggcgagag aagtctgagc      240

ctgctgaact gcgaggaaat caagagccag ttcgagggct tcgtgaagga catcatgctg      300

aacaaagagg aaacgaagaa agagaactcc ttcgagatgc agaagggcga ccagaatcct      360

cagatcgccg ctcacgtgat cagcgaggcc agcagcaaga caacaagcgt gctgcagtgg      420

gccgagaagg gctactacac catgagcaac aacctggtca ccctggagaa cggcaagcag      480

ctgacagtga agcggcaggg cctgtactac atctacgccc aagtgacctt ctgcagcaac      540

agagaggcca gctctcaggc tcctttcatc gccagcctgt gcctgaagtc tcctggcaga      600

ttcgagcgga ttctgctgag agccgccaac acacacagca gcgccaaacc ttgtggccag      660

cagtctattc acctcggcgg agtgtttgag ctgcagcctg gcgcaagcgt gttcgtgaat      720

gtgacagacc ctagccaggt gtcccacggc accggcttta catctttcgg actgctgaag      780

ctgtgatgat ag                                                          792


<210>  3
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  4
<211>  768
<212>  DNA
<213>  Homo sapiens

<400>  4
atggaatacg ccagcgacgc ctctctggac cctgaagctc cttggcctcc agctcctaga       60

gccagggctt gtagagtgct gccttgggct cttgtggctg gacttctgct tctgttgctc      120

ctggctgctg cctgcgcagt gtttcttgct tgtccatggg ctgtgtcagg agccagagca      180

tctcctggat ctgccgcttc tcccagactg agagagggac ctgaactgag ccctgatgat      240

cctgctggac tgctcgacct gagacagggc atgtttgccc agctggtggc ccagaatgtg      300

ctgctgattg atggccctct gagctggtac agcgatcctg gacttgctgg cgttagcctg      360

actggaggcc tgagctacaa ggaggacacc aaagaactgg tggtggccaa ggctggcgtg      420

tactacgtgt tctttcagct ggaactgcgg agagtggtgg caggcgaagg atctggatcc      480

gtgtctctgg cactgcatct gcagcctctg agatctgctg ctggtgcagc tgccctggct      540

ctgacagttg atctgcctcc tgcctccagc gaagccagaa acagcgcctt tggcttccaa      600

ggcagactgc tgcacctgtc tgctggccag agactgggag tgcacctcca cacagaagca      660

agagcaagac acgcctggca gcttacacaa ggcgctacag tgctgggcct gttcagagtg      720

acacctgaga ttccagctgg cttgccatct cctcgcagcg agtaatga                   768


<210>  5
<211>  666
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic ERV-K-gag sequence

<400>  5

Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu 
1               5                   10                  15      


Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr 
            20                  25                  30          


Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp 
        35                  40                  45              


Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly 
    50                  55                  60                  


Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr 
65                  70                  75                  80  


Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln 
                85                  90                  95      


Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Ile 
            100                 105                 110         


Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu 
        115                 120                 125             


Ser Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr 
    130                 135                 140                 


Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr 
145                 150                 155                 160 


Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser 
                165                 170                 175     


Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Thr 
            180                 185                 190         


Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val 
        195                 200                 205             


Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro 
    210                 215                 220                 


Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg 
225                 230                 235                 240 


Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro 
                245                 250                 255     


Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg 
            260                 265                 270         


Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Val Thr Leu Glu Pro 
        275                 280                 285             


Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu 
    290                 295                 300                 


Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu 
305                 310                 315                 320 


Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu 
                325                 330                 335     


Asp Ser Ile Ala His Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile 
            340                 345                 350         


Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr 
        355                 360                 365             


Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala 
    370                 375                 380                 


Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln 
385                 390                 395                 400 


Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile 
                405                 410                 415     


Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp 
            420                 425                 430         


Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys 
        435                 440                 445             


Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys 
    450                 455                 460                 


Ser Ile Ala Asp Glu Lys Ala Arg Lys Val Ile Val Glu Leu Met Ala 
465                 470                 475                 480 


Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys 
                485                 490                 495     


Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala 
            500                 505                 510         


Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln 
        515                 520                 525             


Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly 
    530                 535                 540                 


Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro 
545                 550                 555                 560 


Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg 
                565                 570                 575     


Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala 
            580                 585                 590         


Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly 
        595                 600                 605             


Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe 
    610                 615                 620                 


Pro Ile Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro 
625                 630                 635                 640 


Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn 
                645                 650                 655     


Cys Pro Pro Pro Gln Ala Ala Val Gln Gln 
            660                 665     


<210>  6
<211>  2004
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic ERV-K-gag sequence

<400>  6
atgggacaga ccaagagtaa gatcaagtct aagtacgcca gctacctcag cttcatcaag       60

atcctgctga agagaggagg cgtgaaagtg tccaccaaga acctgatcaa gctgttccag      120

atcatcgagc agttctgtcc ctggtttcct gagcagggca ccctggatct gaaggactgg      180

aagcggatcg gcaaagagct gaagcaggct ggcagaaagg gcaacatcat ccctctgacc      240

gtgtggaacg actgggccat catcaaagca gctctggaac ccttccagac cgaagaggat      300

agcgtgtccg tgtctgatgc tcctggcagc tgcatcatcg actgcaacga gaacacccgg      360

aagaagtccc agaaagagac agagagcctg cactgcgagt acgtggccga acctgtgatg      420

gctcagagca cccagaacgt ggactacaac cagctccaag aagtgatcta tcccgaaaca      480

ctgaagctgg aaggcaaggg acctgaactc gtgggtcctt ctgagtctaa gcccagaggc      540

acatctcctc tgcctgcagg acaggtgcca gtgacactgc agcctcagaa acaagtgaaa      600

gagaacaaga cccagcctcc tgtggcctac cagtattggc ctccagccga gctgcagtac      660

agacctcctc cagagagcca gtacggctac cctggaatgc ctcctgctcc tcaaggcaga      720

gctccttatc ctcagcctcc taccagacgg ctgaacccta cagctcctcc tagcagacag      780

ggctctgagc tgcacgagat cattgacaag agccggaaag agggcgacac cgaggcttgg      840

cagtttcccg ttacactgga acccatgcct ccaggcgaag gcgctcaaga aggcgaacct      900

cctacagtgg aagccaggta caagagcttc agcatcaaga tgctgaagga catgaaggaa      960

ggcgtcaagc agtacggacc taacagccca tacatgcgga ccctgctgga ttctattgcc     1020

cacggccacc ggctgatccc ttacgattgg gagatcctgg ctaagtcctc tctgagccct     1080

agccagttcc tgcagttcaa gacctggtgg atcgacggcg tgcaagaaca agtgagacgg     1140

aacagagctg ccaatcctcc tgtgaacatc gacgccgacc agctcctcgg aatcggccag     1200

aattggagca ccatctctca gcaggctctg atgcagaacg aggccattga acaagtcaga     1260

gccatctgcc tgagagcttg ggagaagatt caggacccag gcagcacatg tcccagcttc     1320

aataccgttc ggcagggcag caaagagccc tatcctgact ttgtggctag actgcaggat     1380

gtggcccaga agtctattgc cgacgagaag gctcggaaag tgatcgtgga actgatggcc     1440

tacgagaacg ctaatccaga gtgccagagc gccatcaagc ccttgaaggg caaagtgcct     1500

gccggatccg atgtgatcag cgagtatgtg aaggcctgcg acggaatcgg aggtgccatg     1560

cacaaagcca tgctgatggc acaggccatc actggcgttg tgctcggagg acaagttcgg     1620

acctttggag gcaagtgcta caactgtggc cagatcggac acctgaagaa gaactgccct     1680

gtgctgaaca agcagaacat caccatccag gccaccacca ccggcagaga acctccagat     1740

ctgtgcccta gatgcaagaa gggcaagcac tgggccagcc agtgcagaag caagttcgac     1800

aagaacggcc agcctctgag cggcaacgaa caaagaggac agcctcaggc tcctcagcag     1860

actggcgcat ttccaatcca gcccttcgtg cctcaaggct tccagggaca acagcctcca     1920

ctgtctcagg tgttccaggg cattagccag ctccctcagt acaacaactg ccctccacct     1980

caggctgctg tgcagcagtg atga                                            2004


<210>  7
<211>  699
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic ERV-K-env/MEL sequence

<400>  7

Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              


Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  


Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      


Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Met 
            100                 105                 110         


Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             


Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 


Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 


Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     


Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         


Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             


Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 


Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 


Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     


Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         


His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             


Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 


Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 


Ser Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     


Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         


Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             


Val Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 


Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 


Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     


Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         


Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             


Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Arg Ser Lys 
    450                 455                 460                 


Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu Ile Ala Val 
465                 470                 475                 480 


Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser Ser Val Gln 
                485                 490                 495     


Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr Arg Leu Trp 
            500                 505                 510         


Asn Ser Gln Ser Ser Ile Asp Gln Lys Met Leu Ala Val Ile Ser Cys 
        515                 520                 525             


Ala Val Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met Ser Leu Glu 
    530                 535                 540                 


His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp Phe Cys Ile 
545                 550                 555                 560 


Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp Met Val Arg 
                565                 570                 575     


Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp Ile Ser Lys 
            580                 585                 590         


Leu Lys Glu Gln Ile Phe Glu Ala Ser Lys Ala His Leu Asn Leu Val 
        595                 600                 605             


Pro Gly Thr Glu Ala Ile Ala Gly Val Ala Asp Gly Leu Ala Asn Leu 
    610                 615                 620                 


Asn Pro Val Thr Trp Val Lys Thr Ile Gly Ser Thr Thr Ile Ile Asn 
625                 630                 635                 640 


Leu Ile Leu Ile Leu Val Cys Leu Phe Cys Leu Leu Leu Val Cys Arg 
                645                 650                 655     


Cys Thr Gln Gln Leu Arg Arg Asp Ser Asp His Arg Glu Arg Ala Met 
            660                 665                 670         


Met Thr Met Ala Val Leu Ser Lys Arg Lys Gly Gly Asn Val Gly Lys 
        675                 680                 685             


Ser Lys Arg Asp Gln Ile Val Thr Val Ser Val 
    690                 695                 


<210>  8
<211>  2103
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic ERV-K-env/MEL sequence

<400>  8
atgaacccta gcgagatgca gagaaaggct ccacctagac ggagaagaca cagaaacagg       60

gctcctctga cacacaagat gaacaagatg gtcaccagcg aggaacagat gaaactgccc      120

agcaccaaga aggccgagcc tccaacatgg gctcagctga agaaactgac ccagctggcc      180

accaagtacc tggagaacac caaagtgacc cagacacctg agagcatgct gctggcagct      240

ctgatgatcg tgtccatggt ggtgtccctg cctatgcctg ctggtgctgc cgctgccaac      300

tacacatact gggcctacgt gccctttcct cctatgatca gagccgtgac ctggatggac      360

aaccctattg aggtgtacgt gaacgacagc gtgtgggtgc caggacctat cgacgataga      420

tgtcctgcca aacctgagga agagggcatg atgatcaaca tcagcatcgg ctaccggtat      480

cctccaatct gcctgggcag agcacctggc tgtcttatgc cagctgtgca gaattggctg      540

gtggaagtgc ctaccgtgtc tcccatcagc cggttcacct accacatggt gtccggcatg      600

agcctcagac ctagagtgaa ctacttgcag gacttcagct atcagcggag cctgaagttc      660

agacccaagg gaaagccctg tcctaaagag attcccaaag agtccaagaa caccgaggtg      720

ctcgtgtggg aagagtgcgt ggccaattct gccgtgatcc tgcagaacaa cgagttcggc      780

accatcattg actgggctcc tagaggccag ttctaccaca attgcagcgg acagacacag      840

agctgtccta gcgcacaagt gtcaccagcc gtggatagcg atctgaccga gagcctggac      900

aagcacaaac acaagaaact tcagagcttc tatccctggg agtggggaga gaagggcatc      960

tctacaccaa ggcctaagat cattagccct gtgtctggac cagaacatcc cgaactttgg     1020

agactgacag tggccagcca ccacatcaga atctggagcg gcaatcagac cctggaaaca     1080

cgggacagaa agcccttcta caccgtcgat ctgaacagca gcctgaccgt gcctctccag     1140

agctgtgtga agcctcctta catgctggtc gtgggcaaca ttgtgatcaa gcccgactcc     1200

cagaccatca catgcgagaa ctgcagactg ctgacctgca tcgacagcac cttcaactgg     1260

cagcaccgga tcctgctcgt gcgagctaga gaaggcgtgt ggatccctgt ctctatggac     1320

aggccttggg aagccagccc tagcgtgcac attctgacag aggtgctgaa gggcgtgctc     1380

aacagatcca agcggttcat cttcaccctg atcgccgtca tcatgggcct gattgctgtg     1440

acagccacag ctgctgttgc tggcgtggcc ctgcatagct ctgtgcagag cgtgaacttc     1500

gtgaacgatt ggcagaagaa cagcacacgg ctgtggaaca gccagagcag catcgaccag     1560

aagatgctgg ccgtgatctc ctgtgccgtg cagacagtta tctggatggg cgacagactg     1620

atgagcctgg aacaccggtt ccagctgcag tgcgactgga ataccagcga cttctgcatc     1680

acacctcaga tctacaacga gagcgagcac cactgggata tggtccgaag gcatctgcag     1740

ggcagagagg acaacctgac actggacatc agcaagctga aagagcagat cttcgaggcc     1800

agcaaggctc acctgaatct ggtgcctgga accgaagcta ttgctggagt tgcagatggc     1860

ctggccaatc tgaatcctgt gacctgggtc aagaccatcg gcagcaccac aatcatcaac     1920

ctgatcctga tcctcgtgtg cctgttttgc ctgctgcttg tgtgcagatg cacccagcag     1980

ctgagaagag acagcgacca tagagaaaga gccatgatga ccatggccgt cctgagcaag     2040

agaaagggag gcaacgtggg caagagcaag cgggatcaga tcgtgaccgt gtccgtttga     2100

taa                                                                   2103


<210>  9
<211>  741
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic hFOLR1-hPRAME fusion sequence

<400>  9

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Glu Arg Arg Arg Leu Trp Gly 
225                 230                 235                 240 


Ser Ile Gln Ser Arg Tyr Ile Ser Met Ser Val Trp Thr Ser Pro Arg 
                245                 250                 255     


Arg Leu Val Glu Leu Ala Gly Gln Ser Leu Leu Lys Asp Glu Ala Leu 
            260                 265                 270         


Ala Ile Ala Ala Leu Glu Leu Leu Pro Arg Glu Leu Phe Pro Pro Leu 
        275                 280                 285             


Phe Met Ala Ala Phe Asp Gly Arg His Ser Gln Thr Leu Lys Ala Met 
    290                 295                 300                 


Val Gln Ala Trp Pro Phe Thr Cys Leu Pro Leu Gly Val Leu Met Lys 
305                 310                 315                 320 


Gly Gln His Leu His Leu Glu Thr Phe Lys Ala Val Leu Asp Gly Leu 
                325                 330                 335     


Asp Val Leu Leu Ala Gln Glu Val Arg Pro Arg Arg Trp Lys Leu Gln 
            340                 345                 350         


Val Leu Asp Leu Arg Lys Asn Ser His Gln Asp Phe Trp Thr Val Trp 
        355                 360                 365             


Ser Gly Asn Arg Ala Ser Leu Tyr Ser Phe Pro Glu Pro Glu Ala Ala 
    370                 375                 380                 


Gln Pro Met Thr Thr Lys Ala Lys Val Asp Gly Leu Ser Thr Glu Ala 
385                 390                 395                 400 


Glu Gln Pro Phe Ile Pro Val Glu Val Leu Val Asp Leu Phe Leu Lys 
                405                 410                 415     


Glu Gly Ala Cys Asp Glu Leu Phe Ser Tyr Leu Ile Glu Lys Val Ala 
            420                 425                 430         


Ala Lys Lys Asn Val Leu Arg Leu Cys Cys Lys Lys Leu Lys Ile Phe 
        435                 440                 445             


Ala Met Pro Met Gln Asp Ile Lys Met Ile Leu Lys Met Val Gln Leu 
    450                 455                 460                 


Asp Ser Ile Glu Asp Leu Glu Val Thr Cys Thr Trp Lys Leu Pro Thr 
465                 470                 475                 480 


Leu Ala Lys Phe Ser Pro Tyr Leu Gly Gln Met Ile Asn Leu Arg Arg 
                485                 490                 495     


Leu Leu Leu Ser His Ile His Ala Ser Ser Tyr Ile Ser Pro Glu Lys 
            500                 505                 510         


Glu Glu Gln Tyr Ile Ala Gln Phe Thr Ser Gln Phe Leu Ser Leu Gln 
        515                 520                 525             


Cys Leu Gln Ala Leu Tyr Val Asp Ser Leu Phe Phe Leu Arg Gly Arg 
    530                 535                 540                 


Leu Asp Gln Leu Leu Arg His Val Met Asn Pro Leu Glu Thr Leu Ser 
545                 550                 555                 560 


Ile Thr Asn Cys Arg Leu Ser Glu Gly Asp Val Met His Leu Ser Gln 
                565                 570                 575     


Ser Pro Ser Val Ser Gln Leu Ser Val Leu Ser Leu Ser Gly Val Met 
            580                 585                 590         


Leu Thr Asp Val Ser Pro Glu Pro Leu Gln Ala Leu Leu Glu Arg Ala 
        595                 600                 605             


Ser Ala Thr Leu Gln Asp Leu Val Phe Asp Glu Cys Gly Ile Thr Asp 
    610                 615                 620                 


Asp Gln Leu Leu Ala Leu Leu Pro Ser Leu Ser His Cys Ser Gln Leu 
625                 630                 635                 640 


Thr Thr Leu Ser Phe Tyr Gly Asn Ser Ile Ser Ile Ser Ala Leu Gln 
                645                 650                 655     


Ser Leu Leu Gln His Leu Ile Gly Leu Ser Asn Leu Thr His Val Leu 
            660                 665                 670         


Tyr Pro Val Pro Leu Glu Ser Tyr Glu Asp Ile His Gly Thr Leu His 
        675                 680                 685             


Leu Glu Arg Leu Ala Tyr Leu His Ala Arg Leu Arg Glu Leu Leu Cys 
    690                 695                 700                 


Glu Leu Gly Arg Pro Ser Met Val Trp Leu Ser Ala Asn Pro Cys Pro 
705                 710                 715                 720 


His Cys Gly Asp Arg Thr Phe Tyr Asp Pro Glu Pro Ile Leu Cys Pro 
                725                 730                 735     


Cys Phe Met Pro Asn 
            740     


<210>  10
<211>  2228
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic hFOLR1-hPRAME fusion nucleotide sequence

<400>  10
tggcccagag aatgaccaca caactgctgc tgctcctggt gtgggttgcc gttgttggag       60

aggcccagac cagaattgcc tgggccagaa ccgagctgct gaacgtgtgc atgaacgcca      120

agcatcacaa agagaagcct ggacctgaag acaagctgca tgaacagtgt cggccttgga      180

gaaagaatgc ttgctgtagc accaacacca gccaagaggc ccacaaggac gtgtcctacc      240

tgtaccggtt caactggaac cactgcggag aaatggctcc tgcctgcaag agacacttca      300

tccaggatac ctgcctgtac gagtgctctc ccaatctcgg accttggatc cagcaagtgg      360

accagagctg gcggaaagaa cgggtgctga atgtgccctt gtgcaaagag gattgcgagc      420

agtggtggga agattgccgg accagctaca catgtaagag caactggcac aaaggctgga      480

actggaccag cggcttcaac aagtgtgccg tgggagctgc ctgccagcct ttccacttct      540

acttcccaac acctaccgtg ctgtgcaacg aaatctggac ccacagctac aaggtgtcca      600

actacagcag aggcagcggc aggtgtatcc agatgtggtt cgatcccgct cagggcaatc      660

ccaatgagga agtggctaga ttctacgctg ctgccatgga aagaagaagg ctctggggca      720

gcatccagag ccggtacatt agcatgagcg tgtggacaag ccctagacgg ctggttgaac      780

tggctggaca gagcctgctc aaggatgagg ccctggccat tgctgctctg gagctgctgc      840

ctagagagct gttccctcct ctgttcatgg ctgccttcga cggcagacac agccagacac      900

tgaaagccat ggtgcaggcc tggcctttca cctgtctgcc tctgggagtg ctgatgaagg      960

gccagcatct gcacctggaa accttcaagg ccgtgctgga cggcctggat gttctcctgg     1020

ctcaagaggt gaggcctcgg cgttggaaac tgcaggttct ggatctgcgg aagaactctc     1080

accaggattt ctggaccgtt tggtccggca acagagccag cctgtacagc tttcctgaac     1140

ctgaggctgc ccagcccatg accacaaagg ccaaagtgga tggcctgagc acagaggccg     1200

agcagccttt cattcccgtc gaagtgctgg tggacctgtt cctgaaagaa ggagcctgcg     1260

atgagctgtt cagctacctg attgagaagg tggcagccaa gaagaacgtg ctgcggctgt     1320

gctgcaagaa gctgaagatc tttgccatgc ctatgcagga tatcaagatg atcctgaaga     1380

tggtgcagct ggacagcatc gaggacctgg aagtgacctg tacctggaag ctgcccacac     1440

tggccaagtt cagcccttac ctgggacaga tgattaacct gcggaggctg ctgctgtctc     1500

acatccacgc cagctcctac atcagccctg agaaagagga acagtatatc gcccagttca     1560

caagccagtt tctgagcctg cagtgtctgc aggccctgta cgtggacagc ctgttctttc     1620

tgagaggcag gctggatcag ctgctgcggc acgtgatgaa ccctctggaa accctgagca     1680

tcaccaactg tagactgagc gagggcgacg tgatgcacct gtctcagagc ccatctgtgt     1740

ctcagctgag cgtgctgtct ctgtctggcg tgatgctgac cgatgtgagc cctgaacctc     1800

tgcaggcact gctggaaaga gcctccgcta ctctgcagga cctggtgttc gatgagtgcg     1860

gcatcaccga tgaccagctg cttgctctgc tgccaagcct gagccactgt agccagctga     1920

caaccctgtc cttctacggc aacagcatct ccatctctgc cctgcagtct ctcctgcagc     1980

atctgatcgg cctgtccaat ctgacccacg tgctgtaccc tgtgccactg gaaagctacg     2040

aggacatcca cggaaccctg cacctcgaga gactggccta tctgcatgct cggctgagag     2100

aactgctgtg cgaactgggc agacccagca tggtttggct gagcgccaat ccatgtcctc     2160

actgtggcga ccggaccttc tacgaccctg agcctatcct gtgtccttgc ttcatgccca     2220

actaatag                                                              2228


<210>  11
<211>  517
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic ERV-K-env/MEL_03 sequence

<400>  11

Met Asn Pro Ser Glu Met Gln Arg Lys Ala Pro Pro Arg Arg Arg Arg 
1               5                   10                  15      


His Arg Asn Arg Ala Pro Leu Thr His Lys Met Asn Lys Met Val Thr 
            20                  25                  30          


Ser Glu Glu Gln Met Lys Leu Pro Ser Thr Lys Lys Ala Glu Pro Pro 
        35                  40                  45              


Thr Trp Ala Gln Leu Lys Lys Leu Thr Gln Leu Ala Thr Lys Tyr Leu 
    50                  55                  60                  


Glu Asn Thr Lys Val Thr Gln Thr Pro Glu Ser Met Leu Leu Ala Ala 
65                  70                  75                  80  


Leu Met Ile Val Ser Met Val Val Ser Leu Pro Met Pro Ala Gly Ala 
                85                  90                  95      


Ala Ala Ala Asn Tyr Thr Tyr Trp Ala Tyr Val Pro Phe Pro Pro Met 
            100                 105                 110         


Ile Arg Ala Val Thr Trp Met Asp Asn Pro Ile Glu Val Tyr Val Asn 
        115                 120                 125             


Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys Pro Ala Lys 
    130                 135                 140                 


Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly Tyr Arg Tyr 
145                 150                 155                 160 


Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met Pro Ala Val 
                165                 170                 175     


Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile Ser Arg Phe 
            180                 185                 190         


Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg Val Asn Tyr 
        195                 200                 205             


Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg Pro Lys Gly 
    210                 215                 220                 


Lys Pro Cys Pro Lys Glu Ile Pro Lys Glu Ser Lys Asn Thr Glu Val 
225                 230                 235                 240 


Leu Val Trp Glu Glu Cys Val Ala Asn Ser Ala Val Ile Leu Gln Asn 
                245                 250                 255     


Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly Gln Phe Tyr 
            260                 265                 270         


His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala Gln Val Ser 
        275                 280                 285             


Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys His Lys His 
    290                 295                 300                 


Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu Lys Gly Ile 
305                 310                 315                 320 


Ser Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly Pro Glu His 
                325                 330                 335     


Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile Arg Ile Trp 
            340                 345                 350         


Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro Phe Tyr Thr 
        355                 360                 365             


Val Asp Leu Asn Ser Ser Leu Thr Val Pro Leu Gln Ser Cys Val Lys 
    370                 375                 380                 


Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys Pro Asp Ser 
385                 390                 395                 400 


Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys Ile Asp Ser 
                405                 410                 415     


Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala Arg Glu Gly 
            420                 425                 430         


Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala Ser Pro Ser 
        435                 440                 445             


Val His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn Met Leu Ala 
    450                 455                 460                 


Val Ile Ser Cys Ala Val Ala Gly Val Ala Leu His Gly Ser Ala Gly 
465                 470                 475                 480 


Ser Ala Ala Gly Ser Gly Glu Phe Val Val Ile Ser Ala Ile Leu Ala 
                485                 490                 495     


Leu Val Val Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp 
            500                 505                 510         


Gln Lys Lys Pro Arg 
        515         


<210>  12
<211>  1557
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ERV-K-env/MEL_03 nucleotide sequence

<400>  12
atgaacccta gcgagatgca gagaaaggct ccacctagac ggagaagaca cagaaacagg       60

gctcctctga cacacaagat gaacaagatg gtcaccagcg aggaacagat gaaactgccc      120

agcaccaaga aggccgagcc tccaacatgg gctcagctga agaaactgac ccagctggcc      180

accaagtacc tggagaacac caaagtgacc cagacacctg agagcatgct gctggcagct      240

ctgatgatcg tgtccatggt ggtgtccctg cctatgcctg ctggtgctgc cgctgccaac      300

tacacatact gggcctacgt gccctttcct cctatgatca gagccgtgac ctggatggac      360

aaccctattg aggtgtacgt gaacgacagc gtgtgggtgc caggacctat cgacgataga      420

tgtcctgcca aacctgagga agagggcatg atgatcaaca tcagcatcgg ctaccggtat      480

cctccaatct gcctgggcag agcacctggc tgtcttatgc cagctgtgca gaattggctg      540

gtggaagtgc ctaccgtgtc tcccatcagc cggttcacct accacatggt gtccggcatg      600

agcctcagac ctagagtgaa ctacttgcag gacttcagct atcagcggag cctgaagttc      660

agacccaagg gaaagccctg tcctaaagag attcccaaag agtccaagaa caccgaggtg      720

ctcgtgtggg aagagtgcgt ggccaattct gccgtgatcc tgcagaacaa cgagttcggc      780

accatcattg actgggctcc tagaggccag ttctaccaca attgcagcgg acagacacag      840

agctgtccta gcgcacaagt gtcaccagcc gtggatagcg atctgaccga gagcctggac      900

aagcacaaac acaagaaact tcagagcttc tatccctggg agtggggaga gaagggcatc      960

tctacaccaa ggcctaagat cattagccct gtgtctggac cagaacatcc cgaactttgg     1020

agactgacag tggccagcca ccacatcaga atctggagcg gcaatcagac cctggaaaca     1080

cgggacagaa agcccttcta caccgtcgat ctgaacagca gcctgaccgt gcctctccag     1140

agctgtgtga agcctcctta catgctggtc gtgggcaaca ttgtgatcaa gcccgactcc     1200

cagaccatca catgcgagaa ctgcagactg ctgacctgca tcgacagcac cttcaactgg     1260

cagcaccgga tcctgctcgt gcgagctaga gaaggcgtgt ggatccctgt ctctatggac     1320

aggccttggg aagccagccc tagcgtgcac attctgacag aggtgctgaa gggcgtgctc     1380

aacatgctgg ccgtgatctc ctgtgccgtg gctggcgtgg ccctgcatgg ctctgctgga     1440

tctgctgctg gaagcggcga gttcgtggtc atctctgcca ttctggctct ggtggtgctg     1500

accatcatca gcctgatcat cctgattatg ctgtggcaga agaagccccg gtgataa        1557


