                         SEQUENCE LISTING

<110>  ڶ(㶫ҽҩ޹˾
 
<120>  PCSK9弰Ӧ

<130>  IP190579

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  369
<212>  DNA
<213>  ˹

<400>  1
gaggtgcagc tggtggagtc tggaggaggc ctggtgcagc ccggaagatc tctgagactg     60

agttgcgccg cttcaggatt cacctttagc tcctacagca tgaactgggt gcggcaggct    120

cctggcaagg ggctggagtg ggtctccgga atctctagtt caagctccta cattagctat    180

gcagactccg tccagggaag gttcaccatc tctcgcgata acggcaagaa cagcctgtat    240

ctgcagatga acagcctgcg agcagaggac acagccctgt acttctgtgc cagagaatat    300

gacttctggt ccgcctatta cgacgccttc gatgtctggg gacaggggac tatggtcact    360

gtctcaagc                                                            369


<210>  2
<211>  123
<212>  PRT
<213>  ˹

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Ser Ser Ser Tyr Ile Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Tyr Asp Phe Trp Ser Ala Tyr Tyr Asp Ala Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  333
<212>  DNA
<213>  ˹

<400>  3
cagagcgaac tgactcagcc aagaagcgtc agtggatcac ctggccagag cgtgacaatc     60

tcctgcaccg gcacaagcag gaacattggc gggggaaatg acgtccactg gtaccagcag    120

catccaggga aggcccccaa actgctgatc tccggagtga ttgagcggag ctccggcgtc    180

cccgatagat tcagcgggtc caagtctgga aacacagctt ctctgactat cagtggcctg    240

caggcagagg acgaagccga ttactattgc cagtctttcg acggcagtct gtcagggagc    300

gtgtttggca ctgggaccga tgtgaccgtc ctg                                 333


<210>  4
<211>  111
<212>  PRT
<213>  ˹

<400>  4

Gln Ser Glu Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Arg Asn Ile Gly Gly Gly 
            20                  25                  30          


Asn Asp Val His Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Ser Gly Val Ile Glu Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Gly Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Thr Gly Thr Asp Val Thr Val Leu 
            100                 105                 110     


<210>  5
<211>  8
<212>  PRT
<213>  ˹

<400>  5

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  ˹

<400>  6

Ile Ser Ser Ser Ser Ser Tyr Ile 
1               5               


<210>  7
<211>  14
<212>  PRT
<213>  ˹

<400>  7

Glu Tyr Asp Phe Trp Ser Ala Tyr Tyr Asp Ala Phe Asp Val 
1               5                   10                  


<210>  8
<211>  9
<212>  PRT
<213>  ˹

<400>  8

Ser Arg Asn Ile Gly Gly Gly Asn Asp 
1               5                   


<210>  9
<211>  3
<212>  PRT
<213>  ˹

<400>  9

Gly Val Ile   
1                               


<210>  10
<211>  11
<212>  PRT
<213>  ˹

<400>  10

Gln Ser Phe Asp Gly Ser Leu Ser Gly Ser Val 
1               5                   10      


<210>  11
<211>  443
<212>  PRT
<213>  ˹

<400>  11

Glu Val Gln Leu Glu Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Tyr Tyr Asn Glu Lys Val 
    50                  55                  60                  


Lys Gly Lys Val Thr Phe Thr Ala Asp Ala Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Phe Tyr Val Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  12
<211>  214
<212>  PRT
<213>  ˹

<400>  12

Asp Ile Glu Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Thr Ser Gln Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Gly Ser Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


