                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
       Bayer Aktiengesellschaft
 
<120>  CHARACTERIZING MODULATORS OF ADAMTS-7 AND ADAMTS-12

<130>  BHC191056 / BI-10432 / BRH-02625

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rPro-hCD (Rat 1-217/Human 237-537)-TEV-2Strep-6His


<220>
<221>  ADAMTS7 rat prodomain (wild-type)
<222>  (1)..(217)

<220>
<221>  ADAMTS7 human catalytic domain
<222>  (218)..(518)

<220>
<221>  TEV cleavage site, 2xStrep tag, and a His tag
<222>  (519)..(562)

<400>  1

Met His Arg Gly Leu Asn Leu Leu Leu Ile Leu Cys Ala Leu Ala Pro 
1               5                   10                  15      


His Val Leu Gly Pro Ala Ser Gly Leu Pro Thr Glu Gly Arg Ala Gly 
            20                  25                  30          


Leu Asp Ile Val His Pro Val Arg Val Asp Ala Gly Gly Ser Phe Leu 
        35                  40                  45              


Ser Tyr Glu Leu Trp Pro Arg Val Leu Arg Lys Arg Asp Val Ser Ala 
    50                  55                  60                  


Ala Gln Ala Ser Ser Ala Phe Tyr Gln Leu Gln Tyr Gln Gly Arg Glu 
65                  70                  75                  80  


Leu Leu Phe Asn Leu Thr Thr Asn Pro Tyr Leu Leu Ala Pro Gly Phe 
                85                  90                  95      


Val Ser Glu Ile Arg Arg Arg Ser Asn Leu Ser Asn Val His Ile Gln 
            100                 105                 110         


Thr Ser Val Pro Thr Cys His Leu Leu Gly Asp Val Gln Asp Pro Glu 
        115                 120                 125             


Leu Glu Gly Gly Phe Ala Ala Ile Ser Ala Cys Asp Gly Leu Arg Gly 
    130                 135                 140                 


Val Phe Gln Leu Ser Asn Glu Asp Tyr Phe Ile Glu Pro Leu Asp Glu 
145                 150                 155                 160 


Val Pro Ala Gln Pro Gly His Ala Gln Pro His Met Val Tyr Lys His 
                165                 170                 175     


Lys Arg Ser Gly Gln Gln Asp Asp Ser Arg Thr Ser Gly Thr Cys Gly 
            180                 185                 190         


Val Gln Gly Ser Pro Glu Leu Lys His Gln Arg Glu His Trp Glu Gln 
        195                 200                 205             


Arg Gln Gln Lys Arg Arg Gln Gln Arg Ser Val Ser Lys Glu Lys Trp 
    210                 215                 220                 


Val Glu Thr Leu Val Val Ala Asp Ala Lys Met Val Glu Tyr His Gly 
225                 230                 235                 240 


Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn Met Val Ala 
                245                 250                 255     


Gly Leu Phe His Asp Pro Ser Ile Gly Asn Pro Ile His Ile Thr Ile 
            260                 265                 270         


Val Arg Leu Val Leu Leu Glu Asp Glu Glu Glu Asp Leu Lys Ile Thr 
        275                 280                 285             


His His Ala Asp Asn Thr Leu Lys Ser Phe Cys Lys Trp Gln Lys Ser 
    290                 295                 300                 


Ile Asn Met Lys Gly Asp Ala His Pro Leu His His Asp Thr Ala Ile 
305                 310                 315                 320 


Leu Leu Thr Arg Lys Asp Leu Cys Ala Ala Met Asn Arg Pro Cys Glu 
                325                 330                 335     


Thr Leu Gly Leu Ser His Val Ala Gly Met Cys Gln Pro His Arg Ser 
            340                 345                 350         


Cys Ser Ile Asn Glu Asp Thr Gly Leu Pro Leu Ala Phe Thr Val Ala 
        355                 360                 365             


His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly Ser Gly Asn 
    370                 375                 380                 


Asp Cys Glu Pro Val Gly Lys Arg Pro Phe Ile Met Ser Pro Gln Leu 
385                 390                 395                 400 


Leu Tyr Asp Ala Ala Pro Leu Thr Trp Ser Arg Cys Ser Arg Gln Tyr 
                405                 410                 415     


Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu Asp Asp Pro 
            420                 425                 430         


Pro Ala Lys Asp Ile Ile Asp Phe Pro Ser Val Pro Pro Gly Val Leu 
        435                 440                 445             


Tyr Asp Val Ser His Gln Cys Arg Leu Gln Tyr Gly Ala Tyr Ser Ala 
    450                 455                 460                 


Phe Cys Glu Asp Met Asp Asn Val Cys His Thr Leu Trp Cys Ser Val 
465                 470                 475                 480 


Gly Thr Thr Cys His Ser Lys Leu Asp Ala Ala Val Asp Gly Thr Arg 
                485                 490                 495     


Cys Gly Glu Asn Lys Trp Cys Leu Ser Gly Glu Cys Val Pro Val Gly 
            500                 505                 510         


Phe Arg Pro Glu Ala Val Gly Ser Glu Asn Leu Tyr Phe Gln Ser Gly 
        515                 520                 525             


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys His His His His 
545                 550                 555                 560 


His His 
        


<210>  2
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rPro-hCD-FM2 (Rat 1-217/Human 237-537 FM2 
       (Q216K))-TEV-2Strep-6His


<220>
<221>  ADAMTS7 rat prodomain (furin mutant Q216K)
<222>  (1)..(217)

<220>
<221>  ADAMTS7 human catalytic domain
<222>  (218)..(518)

<220>
<221>  TEV cleavage site, 2xStrep tag, and a His tag
<222>  (519)..(562)

<400>  2

Met His Arg Gly Leu Asn Leu Leu Leu Ile Leu Cys Ala Leu Ala Pro 
1               5                   10                  15      


His Val Leu Gly Pro Ala Ser Gly Leu Pro Thr Glu Gly Arg Ala Gly 
            20                  25                  30          


Leu Asp Ile Val His Pro Val Arg Val Asp Ala Gly Gly Ser Phe Leu 
        35                  40                  45              


Ser Tyr Glu Leu Trp Pro Arg Val Leu Arg Lys Arg Asp Val Ser Ala 
    50                  55                  60                  


Ala Gln Ala Ser Ser Ala Phe Tyr Gln Leu Gln Tyr Gln Gly Arg Glu 
65                  70                  75                  80  


Leu Leu Phe Asn Leu Thr Thr Asn Pro Tyr Leu Leu Ala Pro Gly Phe 
                85                  90                  95      


Val Ser Glu Ile Arg Arg Arg Ser Asn Leu Ser Asn Val His Ile Gln 
            100                 105                 110         


Thr Ser Val Pro Thr Cys His Leu Leu Gly Asp Val Gln Asp Pro Glu 
        115                 120                 125             


Leu Glu Gly Gly Phe Ala Ala Ile Ser Ala Cys Asp Gly Leu Arg Gly 
    130                 135                 140                 


Val Phe Gln Leu Ser Asn Glu Asp Tyr Phe Ile Glu Pro Leu Asp Glu 
145                 150                 155                 160 


Val Pro Ala Gln Pro Gly His Ala Gln Pro His Met Val Tyr Lys His 
                165                 170                 175     


Lys Arg Ser Gly Gln Gln Asp Asp Ser Arg Thr Ser Gly Thr Cys Gly 
            180                 185                 190         


Val Gln Gly Ser Pro Glu Leu Lys His Gln Arg Glu His Trp Glu Gln 
        195                 200                 205             


Arg Gln Gln Lys Arg Arg Gln Lys Arg Ser Val Ser Lys Glu Lys Trp 
    210                 215                 220                 


Val Glu Thr Leu Val Val Ala Asp Ala Lys Met Val Glu Tyr His Gly 
225                 230                 235                 240 


Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn Met Val Ala 
                245                 250                 255     


Gly Leu Phe His Asp Pro Ser Ile Gly Asn Pro Ile His Ile Thr Ile 
            260                 265                 270         


Val Arg Leu Val Leu Leu Glu Asp Glu Glu Glu Asp Leu Lys Ile Thr 
        275                 280                 285             


His His Ala Asp Asn Thr Leu Lys Ser Phe Cys Lys Trp Gln Lys Ser 
    290                 295                 300                 


Ile Asn Met Lys Gly Asp Ala His Pro Leu His His Asp Thr Ala Ile 
305                 310                 315                 320 


Leu Leu Thr Arg Lys Asp Leu Cys Ala Ala Met Asn Arg Pro Cys Glu 
                325                 330                 335     


Thr Leu Gly Leu Ser His Val Ala Gly Met Cys Gln Pro His Arg Ser 
            340                 345                 350         


Cys Ser Ile Asn Glu Asp Thr Gly Leu Pro Leu Ala Phe Thr Val Ala 
        355                 360                 365             


His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly Ser Gly Asn 
    370                 375                 380                 


Asp Cys Glu Pro Val Gly Lys Arg Pro Phe Ile Met Ser Pro Gln Leu 
385                 390                 395                 400 


Leu Tyr Asp Ala Ala Pro Leu Thr Trp Ser Arg Cys Ser Arg Gln Tyr 
                405                 410                 415     


Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu Asp Asp Pro 
            420                 425                 430         


Pro Ala Lys Asp Ile Ile Asp Phe Pro Ser Val Pro Pro Gly Val Leu 
        435                 440                 445             


Tyr Asp Val Ser His Gln Cys Arg Leu Gln Tyr Gly Ala Tyr Ser Ala 
    450                 455                 460                 


Phe Cys Glu Asp Met Asp Asn Val Cys His Thr Leu Trp Cys Ser Val 
465                 470                 475                 480 


Gly Thr Thr Cys His Ser Lys Leu Asp Ala Ala Val Asp Gly Thr Arg 
                485                 490                 495     


Cys Gly Glu Asn Lys Trp Cys Leu Ser Gly Glu Cys Val Pro Val Gly 
            500                 505                 510         


Phe Arg Pro Glu Ala Val Gly Ser Glu Asn Leu Tyr Phe Gln Ser Gly 
        515                 520                 525             


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys His His His His 
545                 550                 555                 560 


His His 
        


<210>  3
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rADAMTS7 (Rat 1-575)-Flag

<400>  3

Met His Arg Gly Leu Asn Leu Leu Leu Ile Leu Cys Ala Leu Ala Pro 
1               5                   10                  15      


His Val Leu Gly Pro Ala Ser Gly Leu Pro Thr Glu Gly Arg Ala Gly 
            20                  25                  30          


Leu Asp Ile Val His Pro Val Arg Val Asp Ala Gly Gly Ser Phe Leu 
        35                  40                  45              


Ser Tyr Glu Leu Trp Pro Arg Val Leu Arg Lys Arg Asp Val Ser Ala 
    50                  55                  60                  


Ala Gln Ala Ser Ser Ala Phe Tyr Gln Leu Gln Tyr Gln Gly Arg Glu 
65                  70                  75                  80  


Leu Leu Phe Asn Leu Thr Thr Asn Pro Tyr Leu Leu Ala Pro Gly Phe 
                85                  90                  95      


Val Ser Glu Ile Arg Arg Arg Ser Asn Leu Ser Asn Val His Ile Gln 
            100                 105                 110         


Thr Ser Val Pro Thr Cys His Leu Leu Gly Asp Val Gln Asp Pro Glu 
        115                 120                 125             


Leu Glu Gly Gly Phe Ala Ala Ile Ser Ala Cys Asp Gly Leu Arg Gly 
    130                 135                 140                 


Val Phe Gln Leu Ser Asn Glu Asp Tyr Phe Ile Glu Pro Leu Asp Glu 
145                 150                 155                 160 


Val Pro Ala Gln Pro Gly His Ala Gln Pro His Met Val Tyr Lys His 
                165                 170                 175     


Lys Arg Ser Gly Gln Gln Asp Asp Ser Arg Thr Ser Gly Thr Cys Gly 
            180                 185                 190         


Val Gln Gly Ser Pro Glu Leu Lys His Gln Arg Glu His Trp Glu Gln 
        195                 200                 205             


Arg Gln Gln Lys Arg Arg Gln Gln Arg Ser Ile Ser Lys Glu Lys Trp 
    210                 215                 220                 


Val Glu Thr Leu Val Val Ala Asp Ser Lys Met Val Glu Tyr His Gly 
225                 230                 235                 240 


Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn Met Val Ala 
                245                 250                 255     


Gly Leu Tyr His Asp Pro Ser Ile Gly Asn Pro Ile His Ile Thr Val 
            260                 265                 270         


Val Arg Leu Ile Ile Leu Glu Asp Glu Glu Lys Asp Leu Lys Ile Thr 
        275                 280                 285             


His His Ala Asp Asp Thr Leu Lys Asn Phe Cys Arg Trp Gln Lys Asn 
    290                 295                 300                 


Val Asn Met Lys Gly Asp Asp His Pro Gln His His Asp Thr Ala Ile 
305                 310                 315                 320 


Leu Leu Thr Arg Lys Asp Leu Cys Ala Thr Met Asn His Pro Cys Glu 
                325                 330                 335     


Thr Leu Gly Leu Ser His Val Ala Gly Leu Cys His Pro Gln Leu Ser 
            340                 345                 350         


Cys Ser Val Ser Glu Asp Thr Gly Leu Pro Leu Ala Phe Thr Val Ala 
        355                 360                 365             


His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly Thr Gly Asn 
    370                 375                 380                 


Asp Cys Glu Ser Ile Gly Lys Arg Pro Phe Ile Met Ser Pro Gln Leu 
385                 390                 395                 400 


Leu Tyr Asp Arg Gly Ile Pro Leu Thr Trp Ser Arg Cys Ser Arg Glu 
                405                 410                 415     


Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu Asp Asp 
            420                 425                 430         


Arg Pro Ser Lys Gly Val Ile Asn Phe Pro Ser Val Leu Pro Gly Val 
        435                 440                 445             


Leu Tyr Asp Val Asn His Gln Cys Arg Leu Gln Tyr Gly Pro Ser Ser 
    450                 455                 460                 


Ala Tyr Cys Glu Asp Val Asp Asn Val Cys Tyr Thr Leu Trp Cys Ser 
465                 470                 475                 480 


Val Gly Thr Thr Cys His Ser Lys Met Asp Ala Ala Val Asp Gly Thr 
                485                 490                 495     


Ser Cys Gly Lys Asn Lys Trp Cys Leu Asn Gly Glu Cys Val Pro Glu 
            500                 505                 510         


Gly Phe Gln Pro Glu Thr Val Asp Gly Gly Trp Ser Gly Trp Ser Ala 
        515                 520                 525             


Trp Ser Val Cys Ser Arg Ser Cys Gly Val Gly Val Arg Ser Ser Glu 
    530                 535                 540                 


Arg Gln Cys Thr Gln Pro Val Pro Lys Asn Lys Gly Lys Tyr Cys Val 
545                 550                 555                 560 


Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn Leu Gln Ala Cys Pro Glu 
                565                 570                 575     


Asn Leu Tyr Phe Gln Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
            580                 585                 590 


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test substrate for ADAMTS7/12: (HiLyteFluor-488 
       )-DELSSMVLELRGLRT-K(QXL520)-NH2

<400>  4

Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Lys 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test Substrate for ADAMTS7/12: 
       (HiLyteFluor-488)-SSMVLELRGLRTIVT-K(QXL520)-NH2

<400>  5

Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Ile Val Thr Lys 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test Substrate for ADAMTS7/12: 
       (HiLyteFluor-488)-KVTEENKELANELRR-K(QXL520)-NH2

<400>  6

Lys Val Thr Glu Glu Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Lys 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test Substrate for ADAMTS7/12: 
       (HiLyteFluor-488)-EENKELANELRRPPL-K(QXL520)-NH2

<400>  7

Glu Glu Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Lys 
1               5                   10                  15      


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test Substrate for ADAMTS7/12: 
       (HiLyteFluor-488)-SSMVLELRGLRT-K(QXL520)-NH2

<400>  8

Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Lys 
1               5                   10              


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test Substrate for ADAMTS7/12: (Donor) GMQQSVRTGLPS (K-Quencher)

<400>  9

Gly Met Gln Gln Ser Val Arg Thr Gly Leu Pro Ser 
1               5                   10          


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test Substrate for ADAMTS7/12: (Donor) SPGFRCEACPPGYS 
       (K-Quencher)

<400>  10

Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser 
1               5                   10                  


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate for ADAMTS7 and for ADAMTS12: 
       (HiLyteFluor-488)-DELSSMVLELRGLRT-K(QXL520)-E-NH2

<400>  11

Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Lys 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test Substrate for ADAMTS7/12: 
       (HiLyteFluor-488)-DELSSMVLELRGLRT-K(QXL520)-K-NH2

<400>  12

Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Lys 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Test Substrate for ADAMTS7/12: 
       (HiLyteFluor-488)-DELSSMVLELRGLRT-K(QXL520)-OH

<400>  13

Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Lys 
1               5                   10                  15      


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate for ADAMTS4 and for ADAMTS5: 
       Dabcyl-EEVKAKVQPY-Glu(Edans)-NH2

<400>  14

Glu Glu Val Lys Ala Lys Val Gln Pro Tyr 
1               5                   10  


<210>  15
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rPro-hCD for ADAMTS12

<400>  15

Met Pro Cys Ala Gln Gly Asn Trp Met Ala Lys Leu Ser Met Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Phe Cys His Gly Arg Gln Ala Gln Pro 
            20                  25                  30          


Trp Pro Val Arg Phe Pro Asp Pro Lys Gln Glu His Phe Ile Lys Ser 
        35                  40                  45              


Leu Pro Glu Tyr His Ile Val Ser Pro Val Gln Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His His Pro Val Thr Gly Ser Arg Lys 
65                  70                  75                  80  


Lys Arg Ala Ala Gly Gly Ser Gly Asp Gln Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asn Leu Phe Phe Asn Leu Thr Val Asn Trp Glu Phe 
            100                 105                 110         


Leu Ser Asn Gly Tyr Val Val Glu Arg Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Ala Ala Ser Ser Gly Gln Pro Cys His Leu Arg Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Pro Thr Ile Arg Met Gly Thr Ala Ala Leu Ser 
145                 150                 155                 160 


Ala Cys Gln Gly Leu Thr Gly Phe Phe His Leu Pro His Gly Asp Phe 
                165                 170                 175     


Phe Ile Glu Pro Val Lys Lys His Pro Leu Thr Glu Glu Gly Tyr Gln 
            180                 185                 190         


Pro His Val Ile Tyr Arg Arg Gln Ser Tyr Arg Val Pro Glu Thr Lys 
        195                 200                 205             


Glu Pro Thr Cys Gly Leu Lys Asp Ser Leu Asp Asn Ser Val Lys Gln 
    210                 215                 220                 


Glu Leu Gln Arg Glu Lys Trp Glu Arg Lys Asn Trp Pro Ser Arg Ser 
225                 230                 235                 240 


Leu Ser Arg Arg Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Thr Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu 
            260                 265                 270         


Ser Tyr Ile Leu Thr Ile Met Asn Met Val Thr Gly Leu Phe His Asn 
        275                 280                 285             


Pro Ser Ile Gly Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu 
    290                 295                 300                 


Leu Glu Glu Glu Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys 
305                 310                 315                 320 


Thr Leu Ser Ser Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser 
                325                 330                 335     


Asp Leu Asn Pro Val His His Asp Val Ala Val Leu Leu Thr Arg Lys 
            340                 345                 350         


Asp Ile Cys Ala Gly Phe Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser 
        355                 360                 365             


His Leu Ser Gly Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu 
    370                 375                 380                 


Asp Ser Gly Leu Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His 
385                 390                 395                 400 


Ser Phe Gly Ile Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val 
                405                 410                 415     


Gly Arg His Pro Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Thr 
            420                 425                 430         


Pro Leu Thr Trp Ser Lys Cys Ser Glu Glu Tyr Ile Thr Arg Phe Leu 
        435                 440                 445             


Asp Arg Gly Trp Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly 
    450                 455                 460                 


Leu Lys Ser Lys Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His 
465                 470                 475                 480 


Gln Cys Gln Leu Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val 
                485                 490                 495     


Glu Asn Val Cys Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg 
            500                 505                 510         


Ser Lys Leu Asp Ala Ala Ala Asp Gly Thr Gln Cys Gly Glu Lys Lys 
        515                 520                 525             


Trp Cys Met Ala Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser 
    530                 535                 540                 


Ile Pro Gly Gly Gly Gly Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr 
545                 550                 555                 560 


Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
                565                 570             


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS Catalytic Motif Consensus Sequence


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

His Glu Xaa Xaa His Xaa Asx Gly Asn Ser Asx Xaa His Asp 
1               5                   10                  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate for MMP12: Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2

<400>  17

Pro Leu Gly Leu Glu Glu Ala 
1               5           


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate for MMP15: MCA-Lys-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2


<220>
<221>  X
<222>  (6)..(6)
<223>  DPA

<400>  18

Lys Pro Leu Gly Leu Xaa Ala Arg 
1               5               


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate for MMP2: MCA-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2


<220>
<221>  X
<222>  (5)..(5)
<223>  DPA

<400>  19

Pro Leu Gly Leu Xaa Ala Arg 
1               5           


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate for ADAM17: 
       Mca-Pro-Leu-Ala-Gln-Ala-Val-Dap(Dnp)-Arg-Ser-Ser-Ser-Arg-NH2


<220>
<221>  X
<222>  (7)..(7)
<223>  Dap(Dnp)

<400>  20

Pro Leu Ala Gln Ala Val Xaa Arg Ser Ser Ser Arg 
1               5                   10          


<210>  21
<211>  1686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS7 from Q9UKP4

<400>  21

Met Pro Gly Gly Pro Ser Pro Arg Ser Pro Ala Pro Leu Leu Arg Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Cys Ala Leu Ala Pro Gly Ala Pro Gly Pro Ala 
            20                  25                  30          


Pro Gly Arg Ala Thr Glu Gly Arg Ala Ala Leu Asp Ile Val His Pro 
        35                  40                  45              


Val Arg Val Asp Ala Gly Gly Ser Phe Leu Ser Tyr Glu Leu Trp Pro 
    50                  55                  60                  


Arg Ala Leu Arg Lys Arg Asp Val Ser Val Arg Arg Asp Ala Pro Ala 
65                  70                  75                  80  


Phe Tyr Glu Leu Gln Tyr Arg Gly Arg Glu Leu Arg Phe Asn Leu Thr 
                85                  90                  95      


Ala Asn Gln His Leu Leu Ala Pro Gly Phe Val Ser Glu Thr Arg Arg 
            100                 105                 110         


Arg Gly Gly Leu Gly Arg Ala His Ile Arg Ala His Thr Pro Ala Cys 
        115                 120                 125             


His Leu Leu Gly Glu Val Gln Asp Pro Glu Leu Glu Gly Gly Leu Ala 
    130                 135                 140                 


Ala Ile Ser Ala Cys Asp Gly Leu Lys Gly Val Phe Gln Leu Ser Asn 
145                 150                 155                 160 


Glu Asp Tyr Phe Ile Glu Pro Leu Asp Ser Ala Pro Ala Arg Pro Gly 
                165                 170                 175     


His Ala Gln Pro His Val Val Tyr Lys Arg Gln Ala Pro Glu Arg Leu 
            180                 185                 190         


Ala Gln Arg Gly Asp Ser Ser Ala Pro Ser Thr Cys Gly Val Gln Val 
        195                 200                 205             


Tyr Pro Glu Leu Glu Ser Arg Arg Glu Arg Trp Glu Gln Arg Gln Gln 
    210                 215                 220                 


Trp Arg Arg Pro Arg Leu Arg Arg Leu His Gln Arg Ser Val Ser Lys 
225                 230                 235                 240 


Glu Lys Trp Val Glu Thr Leu Val Val Ala Asp Ala Lys Met Val Glu 
                245                 250                 255     


Tyr His Gly Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn 
            260                 265                 270         


Met Val Ala Gly Leu Phe His Asp Pro Ser Ile Gly Asn Pro Ile His 
        275                 280                 285             


Ile Thr Ile Val Arg Leu Val Leu Leu Glu Asp Glu Glu Glu Asp Leu 
    290                 295                 300                 


Lys Ile Thr His His Ala Asp Asn Thr Leu Lys Ser Phe Cys Lys Trp 
305                 310                 315                 320 


Gln Lys Ser Ile Asn Met Lys Gly Asp Ala His Pro Leu His His Asp 
                325                 330                 335     


Thr Ala Ile Leu Leu Thr Arg Lys Asp Leu Cys Ala Ala Met Asn Arg 
            340                 345                 350         


Pro Cys Glu Thr Leu Gly Leu Ser His Val Ala Gly Met Cys Gln Pro 
        355                 360                 365             


His Arg Ser Cys Ser Ile Asn Glu Asp Thr Gly Leu Pro Leu Ala Phe 
    370                 375                 380                 


Thr Val Ala His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly 
385                 390                 395                 400 


Ser Gly Asn Asp Cys Glu Pro Val Gly Lys Arg Pro Phe Ile Met Ser 
                405                 410                 415     


Pro Gln Leu Leu Tyr Asp Ala Ala Pro Leu Thr Trp Ser Arg Cys Ser 
            420                 425                 430         


Arg Gln Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu 
        435                 440                 445             


Asp Asp Pro Pro Ala Lys Asp Ile Ile Asp Phe Pro Ser Val Pro Pro 
    450                 455                 460                 


Gly Val Leu Tyr Asp Val Ser His Gln Cys Arg Leu Gln Tyr Gly Ala 
465                 470                 475                 480 


Tyr Ser Ala Phe Cys Glu Asp Met Asp Asn Val Cys His Thr Leu Trp 
                485                 490                 495     


Cys Ser Val Gly Thr Thr Cys His Ser Lys Leu Asp Ala Ala Val Asp 
            500                 505                 510         


Gly Thr Arg Cys Gly Glu Asn Lys Trp Cys Leu Ser Gly Glu Cys Val 
        515                 520                 525             


Pro Val Gly Phe Arg Pro Glu Ala Val Asp Gly Gly Trp Ser Gly Trp 
    530                 535                 540                 


Ser Ala Trp Ser Ile Cys Ser Arg Ser Cys Gly Met Gly Val Gln Ser 
545                 550                 555                 560 


Ala Glu Arg Gln Cys Thr Gln Pro Thr Pro Lys Tyr Lys Gly Arg Tyr 
                565                 570                 575     


Cys Val Gly Glu Arg Lys Arg Phe Arg Leu Cys Asn Leu Gln Ala Cys 
            580                 585                 590         


Pro Ala Gly Arg Pro Ser Phe Arg His Val Gln Cys Ser His Phe Asp 
        595                 600                 605             


Ala Met Leu Tyr Lys Gly Gln Leu His Thr Trp Val Pro Val Val Asn 
    610                 615                 620                 


Asp Val Asn Pro Cys Glu Leu His Cys Arg Pro Ala Asn Glu Tyr Phe 
625                 630                 635                 640 


Ala Glu Lys Leu Arg Asp Ala Val Val Asp Gly Thr Pro Cys Tyr Gln 
                645                 650                 655     


Val Arg Ala Ser Arg Asp Leu Cys Ile Asn Gly Ile Cys Lys Asn Val 
            660                 665                 670         


Gly Cys Asp Phe Glu Ile Asp Ser Gly Ala Met Glu Asp Arg Cys Gly 
        675                 680                 685             


Val Cys His Gly Asn Gly Ser Thr Cys His Thr Val Ser Gly Thr Phe 
    690                 695                 700                 


Glu Glu Ala Glu Gly Leu Gly Tyr Val Asp Val Gly Leu Ile Pro Ala 
705                 710                 715                 720 


Gly Ala Arg Glu Ile Arg Ile Gln Glu Val Ala Glu Ala Ala Asn Phe 
                725                 730                 735     


Leu Ala Leu Arg Ser Glu Asp Pro Glu Lys Tyr Phe Leu Asn Gly Gly 
            740                 745                 750         


Trp Thr Ile Gln Trp Asn Gly Asp Tyr Gln Val Ala Gly Thr Thr Phe 
        755                 760                 765             


Thr Tyr Ala Arg Arg Gly Asn Trp Glu Asn Leu Thr Ser Pro Gly Pro 
    770                 775                 780                 


Thr Lys Glu Pro Val Trp Ile Gln Leu Leu Phe Gln Glu Ser Asn Pro 
785                 790                 795                 800 


Gly Val His Tyr Glu Tyr Thr Ile His Arg Glu Ala Gly Gly His Asp 
                805                 810                 815     


Glu Val Pro Pro Pro Val Phe Ser Trp His Tyr Gly Pro Trp Thr Lys 
            820                 825                 830         


Cys Thr Val Thr Cys Gly Arg Gly Val Gln Arg Gln Asn Val Tyr Cys 
        835                 840                 845             


Leu Glu Arg Gln Ala Gly Pro Val Asp Glu Glu His Cys Asp Pro Leu 
    850                 855                 860                 


Gly Arg Pro Asp Asp Gln Gln Arg Lys Cys Ser Glu Gln Pro Cys Pro 
865                 870                 875                 880 


Ala Arg Trp Trp Ala Gly Glu Trp Gln Leu Cys Ser Ser Ser Cys Gly 
                885                 890                 895     


Pro Gly Gly Leu Ser Arg Arg Ala Val Leu Cys Ile Arg Ser Val Gly 
            900                 905                 910         


Leu Asp Glu Gln Ser Ala Leu Glu Pro Pro Ala Cys Glu His Leu Pro 
        915                 920                 925             


Arg Pro Pro Thr Glu Thr Pro Cys Asn Arg His Val Pro Cys Pro Ala 
    930                 935                 940                 


Thr Trp Ala Val Gly Asn Trp Ser Gln Cys Ser Val Thr Cys Gly Glu 
945                 950                 955                 960 


Gly Thr Gln Arg Arg Asn Val Leu Cys Thr Asn Asp Thr Gly Val Pro 
                965                 970                 975     


Cys Asp Glu Ala Gln Gln Pro Ala Ser Glu Val Thr Cys Ser Leu Pro 
            980                 985                 990         


Leu Cys Arg Trp Pro Leu Gly Thr  Leu Gly Pro Glu Gly  Ser Gly Ser 
        995                 1000                 1005             


Gly Ser  Ser Ser His Glu Leu  Phe Asn Glu Ala Asp  Phe Ile Pro 
    1010                 1015                 1020             


His His  Leu Ala Pro Arg Pro  Ser Pro Ala Ser Ser  Pro Lys Pro 
    1025                 1030                 1035             


Gly Thr  Met Gly Asn Ala Ile  Glu Glu Glu Ala Pro  Glu Leu Asp 
    1040                 1045                 1050             


Leu Pro  Gly Pro Val Phe Val  Asp Asp Phe Tyr Tyr  Asp Tyr Asn 
    1055                 1060                 1065             


Phe Ile  Asn Phe His Glu Asp  Leu Ser Tyr Gly Pro  Ser Glu Glu 
    1070                 1075                 1080             


Pro Asp  Leu Asp Leu Ala Gly  Thr Gly Asp Arg Thr  Pro Pro Pro 
    1085                 1090                 1095             


His Ser  His Pro Ala Ala Pro  Ser Thr Gly Ser Pro  Val Pro Ala 
    1100                 1105                 1110             


Thr Glu  Pro Pro Ala Ala Lys  Glu Glu Gly Val Leu  Gly Pro Trp 
    1115                 1120                 1125             


Ser Pro  Ser Pro Trp Pro Ser  Gln Ala Gly Arg Ser  Pro Pro Pro 
    1130                 1135                 1140             


Pro Ser  Glu Gln Thr Pro Gly  Asn Pro Leu Ile Asn  Phe Leu Pro 
    1145                 1150                 1155             


Glu Glu  Asp Thr Pro Ile Gly  Ala Pro Asp Leu Gly  Leu Pro Ser 
    1160                 1165                 1170             


Leu Ser  Trp Pro Arg Val Ser  Thr Asp Gly Leu Gln  Thr Pro Ala 
    1175                 1180                 1185             


Thr Pro  Glu Ser Gln Asn Asp  Phe Pro Val Gly Lys  Asp Ser Gln 
    1190                 1195                 1200             


Ser Gln  Leu Pro Pro Pro Trp  Arg Asp Arg Thr Asn  Glu Val Phe 
    1205                 1210                 1215             


Lys Asp  Asp Glu Glu Pro Lys  Gly Arg Gly Ala Pro  His Leu Pro 
    1220                 1225                 1230             


Pro Arg  Pro Ser Ser Thr Leu  Pro Pro Leu Ser Pro  Val Gly Ser 
    1235                 1240                 1245             


Thr His  Ser Ser Pro Ser Pro  Asp Val Ala Glu Leu  Trp Thr Gly 
    1250                 1255                 1260             


Gly Thr  Val Ala Trp Glu Pro  Ala Leu Glu Gly Gly  Leu Gly Pro 
    1265                 1270                 1275             


Val Asp  Ser Glu Leu Trp Pro  Thr Val Gly Val Ala  Ser Leu Leu 
    1280                 1285                 1290             


Pro Pro  Pro Ile Ala Pro Leu  Pro Glu Met Lys Val  Arg Asp Ser 
    1295                 1300                 1305             


Ser Leu  Glu Pro Gly Thr Pro  Ser Phe Pro Thr Pro  Gly Pro Gly 
    1310                 1315                 1320             


Ser Trp  Asp Leu Gln Thr Val  Ala Val Trp Gly Thr  Phe Leu Pro 
    1325                 1330                 1335             


Thr Thr  Leu Thr Gly Leu Gly  His Met Pro Glu Pro  Ala Leu Asn 
    1340                 1345                 1350             


Pro Gly  Pro Lys Gly Gln Pro  Glu Ser Leu Ser Pro  Glu Val Pro 
    1355                 1360                 1365             


Leu Ser  Ser Arg Leu Leu Ser  Thr Pro Ala Trp Asp  Ser Pro Ala 
    1370                 1375                 1380             


Asn Ser  His Arg Val Pro Glu  Thr Gln Pro Leu Ala  Pro Ser Leu 
    1385                 1390                 1395             


Ala Glu  Ala Gly Pro Pro Ala  Asp Pro Leu Val Val  Arg Asn Ala 
    1400                 1405                 1410             


Gly Trp  Gln Ala Gly Asn Trp  Ser Glu Cys Ser Thr  Thr Cys Gly 
    1415                 1420                 1425             


Leu Gly  Ala Val Trp Arg Pro  Val Arg Cys Ser Ser  Gly Arg Asp 
    1430                 1435                 1440             


Glu Asp  Cys Ala Pro Ala Gly  Arg Pro Gln Pro Ala  Arg Arg Cys 
    1445                 1450                 1455             


His Leu  Arg Pro Cys Ala Thr  Trp His Ser Gly Asn  Trp Ser Lys 
    1460                 1465                 1470             


Cys Ser  Arg Ser Cys Gly Gly  Gly Ser Ser Val Arg  Asp Val Gln 
    1475                 1480                 1485             


Cys Val  Asp Thr Arg Asp Leu  Arg Pro Leu Arg Pro  Phe His Cys 
    1490                 1495                 1500             


Gln Pro  Gly Pro Ala Lys Pro  Pro Ala His Arg Pro  Cys Gly Ala 
    1505                 1510                 1515             


Gln Pro  Cys Leu Ser Trp Tyr  Thr Ser Ser Trp Arg  Glu Cys Ser 
    1520                 1525                 1530             


Glu Ala  Cys Gly Gly Gly Glu  Gln Gln Arg Leu Val  Thr Cys Pro 
    1535                 1540                 1545             


Glu Pro  Gly Leu Cys Glu Glu  Ala Leu Arg Pro Asn  Thr Thr Arg 
    1550                 1555                 1560             


Pro Cys  Asn Thr His Pro Cys  Thr Gln Trp Val Val  Gly Pro Trp 
    1565                 1570                 1575             


Gly Gln  Cys Ser Gly Pro Cys  Gly Gly Gly Val Gln  Arg Arg Leu 
    1580                 1585                 1590             


Val Lys  Cys Val Asn Thr Gln  Thr Gly Leu Pro Glu  Glu Asp Ser 
    1595                 1600                 1605             


Asp Gln  Cys Gly His Glu Ala  Trp Pro Glu Ser Ser  Arg Pro Cys 
    1610                 1615                 1620             


Gly Thr  Glu Asp Cys Glu Pro  Val Glu Pro Pro Arg  Cys Glu Arg 
    1625                 1630                 1635             


Asp Arg  Leu Ser Phe Gly Phe  Cys Glu Thr Leu Arg  Leu Leu Gly 
    1640                 1645                 1650             


Arg Cys  Gln Leu Pro Thr Ile  Arg Thr Gln Cys Cys  Arg Ser Cys 
    1655                 1660                 1665             


Ser Pro  Pro Ser His Gly Ala  Pro Ser Arg Gly His  Gln Arg Val 
    1670                 1675                 1680             


Ala Arg  Arg 
    1685     


<210>  22
<211>  1595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat ADAMTS7 from Q1EHB3

<400>  22

Met His Arg Gly Leu Asn Leu Leu Leu Ile Leu Cys Ala Leu Ala Pro 
1               5                   10                  15      


His Val Leu Gly Pro Ala Ser Gly Leu Pro Thr Glu Gly Arg Ala Gly 
            20                  25                  30          


Leu Asp Ile Val His Pro Val Arg Val Asp Ala Gly Gly Ser Phe Leu 
        35                  40                  45              


Ser Tyr Glu Leu Trp Pro Arg Val Leu Arg Lys Arg Asp Val Ser Ala 
    50                  55                  60                  


Ala Gln Ala Ser Ser Ala Phe Tyr Gln Leu Gln Tyr Gln Gly Arg Glu 
65                  70                  75                  80  


Leu Leu Phe Asn Leu Thr Thr Asn Pro Tyr Leu Leu Ala Pro Gly Phe 
                85                  90                  95      


Val Ser Glu Ile Arg Arg Arg Ser Asn Leu Ser Asn Val His Ile Gln 
            100                 105                 110         


Thr Ser Val Pro Thr Cys His Leu Leu Gly Asp Val Gln Asp Pro Glu 
        115                 120                 125             


Leu Glu Gly Gly Phe Ala Ala Ile Ser Ala Cys Asp Gly Leu Arg Gly 
    130                 135                 140                 


Val Phe Gln Leu Ser Asn Glu Asp Tyr Phe Ile Glu Pro Leu Asp Glu 
145                 150                 155                 160 


Val Pro Ala Gln Pro Gly His Ala Gln Pro His Met Val Tyr Lys His 
                165                 170                 175     


Lys Arg Ser Gly Gln Gln Asp Asp Ser Arg Thr Ser Gly Thr Cys Gly 
            180                 185                 190         


Val Gln Gly Ser Pro Glu Leu Lys His Gln Arg Glu His Trp Glu Gln 
        195                 200                 205             


Arg Gln Gln Lys Arg Arg Gln Gln Arg Ser Ile Ser Lys Glu Lys Trp 
    210                 215                 220                 


Val Glu Thr Leu Val Val Ala Asp Ser Lys Met Val Glu Tyr His Gly 
225                 230                 235                 240 


Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn Met Val Ala 
                245                 250                 255     


Gly Leu Tyr His Asp Pro Ser Ile Gly Asn Pro Ile His Ile Thr Val 
            260                 265                 270         


Val Arg Leu Ile Ile Leu Glu Asp Glu Glu Lys Asp Leu Lys Ile Thr 
        275                 280                 285             


His His Ala Asp Asp Thr Leu Lys Asn Phe Cys Arg Trp Gln Lys Asn 
    290                 295                 300                 


Val Asn Met Lys Gly Asp Asp His Pro Gln His His Asp Thr Ala Ile 
305                 310                 315                 320 


Leu Leu Thr Arg Lys Asp Leu Cys Ala Thr Met Asn His Pro Cys Glu 
                325                 330                 335     


Thr Leu Gly Leu Ser His Val Ala Gly Leu Cys His Pro Gln Leu Ser 
            340                 345                 350         


Cys Ser Val Ser Glu Asp Thr Gly Leu Pro Leu Ala Phe Thr Val Ala 
        355                 360                 365             


His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly Thr Gly Asn 
    370                 375                 380                 


Asp Cys Glu Ser Ile Gly Lys Arg Pro Phe Ile Met Ser Pro Gln Leu 
385                 390                 395                 400 


Leu Tyr Asp Arg Gly Ile Pro Leu Thr Trp Ser Arg Cys Ser Arg Glu 
                405                 410                 415     


Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu Asp Asp 
            420                 425                 430         


Arg Pro Ser Lys Gly Val Ile Asn Phe Pro Ser Val Leu Pro Gly Val 
        435                 440                 445             


Leu Tyr Asp Val Asn His Gln Cys Arg Leu Gln Tyr Gly Pro Ser Ser 
    450                 455                 460                 


Ala Tyr Cys Glu Asp Val Asp Asn Val Cys Tyr Thr Leu Trp Cys Ser 
465                 470                 475                 480 


Val Gly Thr Thr Cys His Ser Lys Met Asp Ala Ala Val Asp Gly Thr 
                485                 490                 495     


Ser Cys Gly Lys Asn Lys Trp Cys Leu Asn Gly Glu Cys Val Pro Glu 
            500                 505                 510         


Gly Phe Gln Pro Glu Thr Val Asp Gly Gly Trp Ser Gly Trp Ser Ala 
        515                 520                 525             


Trp Ser Val Cys Ser Arg Ser Cys Gly Val Gly Val Arg Ser Ser Glu 
    530                 535                 540                 


Arg Gln Cys Thr Gln Pro Val Pro Lys Asn Lys Gly Lys Tyr Cys Val 
545                 550                 555                 560 


Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn Leu Gln Ala Cys Pro Pro 
                565                 570                 575     


Asp Arg Pro Ser Phe Arg His Thr Gln Cys Ser Gln Phe Asp Ser Met 
            580                 585                 590         


Leu Tyr Lys Gly Lys Leu His Lys Trp Val Pro Val Leu Asn Asp Glu 
        595                 600                 605             


Asn Pro Cys Glu Leu His Cys Arg Pro Phe Asn Tyr Ser Asn Arg Glu 
    610                 615                 620                 


Lys Leu Arg Asp Ala Val Met Asp Gly Thr Pro Cys Tyr Gln Gly Arg 
625                 630                 635                 640 


Ile Ser Arg Asp Ile Cys Ile Asp Gly Ile Cys Lys Lys Val Gly Cys 
                645                 650                 655     


Asp Phe Glu Leu Asp Ser Gly Ala Glu Glu Asp Arg Cys Gly Val Cys 
            660                 665                 670         


Arg Gly Asp Gly Ser Thr Cys His Thr Val Ser Arg Thr Phe Lys Glu 
        675                 680                 685             


Ala Glu Gly Met Gly Tyr Val Asp Val Gly Leu Ile Pro Ala Gly Ala 
    690                 695                 700                 


Arg Glu Ile Leu Ile Glu Glu Val Ala Glu Ala Ala Asn Phe Leu Ala 
705                 710                 715                 720 


Leu Arg Ser Glu Asp Pro Asp Lys Tyr Phe Leu Asn Gly Gly Trp Thr 
                725                 730                 735     


Ile Gln Trp Asn Gly Asp Tyr Gln Val Ala Gly Thr Thr Phe Thr Tyr 
            740                 745                 750         


Thr Arg Lys Gly Asn Trp Glu Thr Leu Thr Ser Pro Gly Pro Thr Thr 
        755                 760                 765             


Glu Pro Val Trp Ile Gln Leu Leu Phe Gln Glu Arg Asn Pro Gly Val 
    770                 775                 780                 


His Tyr Lys Tyr Thr Ile Gln Arg Ala Ser His Ser Glu Ala Gln Pro 
785                 790                 795                 800 


Pro Glu Phe Ser Trp His Tyr Gly Pro Trp Ser Lys Cys Pro Val Thr 
                805                 810                 815     


Cys Gly Thr Gly Val Gln Arg Gln Ser Leu Tyr Cys Met Glu Lys Gln 
            820                 825                 830         


Ala Gly Ile Val Asp Glu Gly His Cys Asp His Leu Ser Arg Pro Arg 
        835                 840                 845             


Asp Arg Lys Arg Lys Cys Asn Glu Glu Pro Cys Pro Ala Arg Trp Trp 
    850                 855                 860                 


Val Gly Asp Trp Gln Pro Cys Ser Arg Ser Cys Gly Pro Gly Gly Phe 
865                 870                 875                 880 


Phe Arg Arg Ala Val Phe Cys Thr Arg Ser Val Gly Leu Asp Glu Gln 
                885                 890                 895     


Arg Ala Leu Glu Pro Ser Ala Cys Gly His Leu Pro Arg Pro Leu Ala 
            900                 905                 910         


Glu Ile Pro Cys Tyr His Tyr Val Ala Cys Pro Ser Ser Trp Gly Val 
        915                 920                 925             


Gly Asn Trp Ser Gln Cys Ser Val Thr Cys Gly Ala Gly Ile Arg Gln 
    930                 935                 940                 


Arg Ser Val Leu Cys Ile Asn Asn Thr Gly Val Pro Cys Asp Gly Ala 
945                 950                 955                 960 


Glu Arg Pro Ile Thr Glu Thr Phe Cys Phe Leu Gln Pro Cys Gln Tyr 
                965                 970                 975     


Ser Thr Tyr Ile Val Asp Thr Gly Ala Ser Gly Ser Gly Ser Ser Ser 
            980                 985                 990         


Pro Glu Leu Phe Asn Glu Val Asp  Phe Asp Pro His Gln  Pro Val Pro 
        995                 1000                 1005             


Arg Pro  Ser Pro Ala Ser Ser  Pro Lys Pro Val Ser  Ile Ser Asn 
    1010                 1015                 1020             


Ala Ile  Asp Glu Glu Asp Pro  Glu Leu Asp Pro Pro  Gly Pro Val 
    1025                 1030                 1035             


Phe Val  Asp Asp Phe Tyr Tyr  Asp Tyr Asn Phe Ile  Asn Phe His 
    1040                 1045                 1050             


Glu Asp  Leu Ser Tyr Gly Ser  Phe Glu Glu Ser His  Ser Asp Leu 
    1055                 1060                 1065             


Val Asp  Ile Gly Gly Gln Thr  Val Pro Pro His Ile  Arg Pro Thr 
    1070                 1075                 1080             


Glu Pro  Pro Ser Asp Ser Pro  Val Pro Thr Ala Gly  Ala Pro Gly 
    1085                 1090                 1095             


Ala Glu  Glu Glu Gly Ile Gln  Gly Ser Trp Ser Pro  Ser Pro Leu 
    1100                 1105                 1110             


Leu Ser  Glu Ala Ser His Ser  Pro Pro Val Leu Leu  Glu Asn Thr 
    1115                 1120                 1125             


Pro Val  Asn Pro Leu Ala Asn  Phe Leu Thr Glu Glu  Glu Ser Pro 
    1130                 1135                 1140             


Ile Gly  Ala Pro Glu Leu Gly  Leu Pro Ser Val Ser  Trp Pro Pro 
    1145                 1150                 1155             


Ala Ser  Val Asp Gly Met Val  Thr Ser Val Ala Pro  Gly Asn Pro 
    1160                 1165                 1170             


Asp Glu  Leu Leu Val Arg Glu  Asp Thr Gln Ser Gln  Pro Ser Thr 
    1175                 1180                 1185             


Pro Trp  Ser Asp Arg Asn Lys  Leu Ser Lys Asp Gly  Asn Pro Leu 
    1190                 1195                 1200             


Gly Pro  Thr Ser Pro Ala Leu  Pro Lys Ser Pro Phe  Pro Thr Gln 
    1205                 1210                 1215             


Pro Ser  Ser Pro Ser Asn Ser  Thr Thr Gln Ala Ser  Leu Ser Pro 
    1220                 1225                 1230             


Asp Ala  Val Glu Val Ser Thr  Gly Trp Asn Val Ala  Leu Asp Pro 
    1235                 1240                 1245             


Val Leu  Glu Ala Asp Leu Lys  Pro Val His Ala Pro  Thr Asp Pro 
    1250                 1255                 1260             


Gly Leu  Leu Asp Gln Ile Gln  Thr Pro His Thr Glu  Gly Thr Gln 
    1265                 1270                 1275             


Ser Pro  Gly Leu Leu Pro Arg  Pro Ala Gln Glu Thr  Gln Thr Asn 
    1280                 1285                 1290             


Ser Ser  Lys Asp Pro Ala Val  Gln Pro Leu Gln Pro  Ser Leu Val 
    1295                 1300                 1305             


Glu Asp  Gly Ala Pro Thr Asp  Leu Leu Pro Ala Lys  Asn Ala Ser 
    1310                 1315                 1320             


Trp Gln  Val Gly Asn Trp Ser  Gln Cys Ser Thr Thr  Cys Gly Leu 
    1325                 1330                 1335             


Gly Ala  Ile Trp Arg Leu Val  Arg Cys Ser Ser Gly  Asn Asp Glu 
    1340                 1345                 1350             


Asp Cys  Thr Leu Ser Ser Arg  Pro Gln Pro Ala Arg  His Cys His 
    1355                 1360                 1365             


Leu Arg  Pro Cys Ala Ala Trp  Arg Ala Gly Asn Trp  Ser Lys Cys 
    1370                 1375                 1380             


Ser Arg  Asn Cys Gly Gly Gly  Ser Ala Thr Arg Asp  Val Gln Cys 
    1385                 1390                 1395             


Val Asp  Thr Arg Asp Leu Arg  Pro Leu Arg Pro Phe  His Cys Gln 
    1400                 1405                 1410             


Pro Gly  Pro Thr Lys Pro Pro  Thr Arg Gln Leu Cys  Gly Thr Gln 
    1415                 1420                 1425             


Pro Cys  Leu Pro Trp Tyr Thr  Ser Ser Trp Arg Glu  Cys Ser Glu 
    1430                 1435                 1440             


Ala Cys  Gly Gly Gly Glu Gln  Gln Arg Leu Val Thr  Cys Pro Glu 
    1445                 1450                 1455             


Pro Gly  Leu Cys Glu Glu Ser  Leu Arg Pro Asn Asn  Thr Arg Pro 
    1460                 1465                 1470             


Cys Asn  Thr His Pro Cys Thr  Gln Trp Val Val Gly  Pro Trp Gly 
    1475                 1480                 1485             


Gln Cys  Ser Ala Pro Cys Gly  Gly Gly Val Gln Arg  Arg Leu Val 
    1490                 1495                 1500             


Lys Cys  Val Asn Thr Gln Thr  Gly Leu Ala Glu Glu  Asp Ser Asp 
    1505                 1510                 1515             


Leu Cys  Ser His Glu Ala Trp  Pro Glu Ser Ser Arg  Pro Cys Ala 
    1520                 1525                 1530             


Thr Glu  Asp Cys Glu Leu Val  Glu Pro Ser Arg Cys  Glu Arg Asp 
    1535                 1540                 1545             


Arg Leu  Pro Phe Asn Phe Cys  Glu Thr Leu Arg Leu  Leu Gly Arg 
    1550                 1555                 1560             


Cys Gln  Leu Pro Thr Ile Arg  Ala Gln Cys Cys Arg  Ser Cys Pro 
    1565                 1570                 1575             


Pro Leu  Ser Arg Gly Val Pro  Ser Arg Gly His Gln  Arg Val Ala 
    1580                 1585                 1590             


Arg Arg  
    1595 


<210>  23
<211>  1657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse ADAMTS7 from Q68SA9

<400>  23

Met His Arg Gly Pro Ser Leu Leu Leu Ile Leu Cys Ala Leu Ala Ser 
1               5                   10                  15      


Arg Val Leu Gly Pro Ala Ser Gly Leu Val Thr Glu Gly Arg Ala Gly 
            20                  25                  30          


Leu Asp Ile Val His Pro Val Arg Val Asp Ala Gly Gly Ser Phe Leu 
        35                  40                  45              


Ser Tyr Glu Leu Trp Pro Arg Val Leu Arg Lys Arg Asp Val Ser Thr 
    50                  55                  60                  


Thr Gln Ala Ser Ser Ala Phe Tyr Gln Leu Gln Tyr Gln Gly Arg Glu 
65                  70                  75                  80  


Leu Leu Phe Asn Leu Thr Thr Asn Pro Tyr Leu Met Ala Pro Gly Phe 
                85                  90                  95      


Val Ser Glu Ile Arg Arg His Ser Thr Leu Gly His Ala His Ile Gln 
            100                 105                 110         


Thr Ser Val Pro Thr Cys His Leu Leu Gly Asp Val Gln Asp Pro Glu 
        115                 120                 125             


Leu Glu Gly Gly Phe Ala Ala Ile Ser Ala Cys Asp Gly Leu Arg Gly 
    130                 135                 140                 


Val Phe Gln Leu Ser Asn Glu Asp Tyr Phe Ile Glu Pro Leu Asp Gly 
145                 150                 155                 160 


Val Ser Ala Gln Pro Gly His Ala Gln Pro His Val Val Tyr Lys His 
                165                 170                 175     


Gln Gly Ser Arg Lys Gln Ala Gln Gln Gly Asp Ser Arg Pro Ser Gly 
            180                 185                 190         


Thr Cys Gly Met Gln Val Pro Pro Asp Leu Glu Gln Gln Arg Glu His 
        195                 200                 205             


Trp Glu Gln Gln Gln Gln Lys Arg Arg Gln Gln Arg Ser Val Ser Lys 
    210                 215                 220                 


Glu Lys Trp Val Glu Thr Leu Val Val Ala Asp Ser Lys Met Val Glu 
225                 230                 235                 240 


Tyr His Gly Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn 
                245                 250                 255     


Met Val Ala Gly Leu Phe His Asp Pro Ser Ile Gly Asn Pro Ile His 
            260                 265                 270         


Ile Ser Ile Val Arg Leu Ile Ile Leu Glu Asp Glu Glu Lys Asp Leu 
        275                 280                 285             


Lys Ile Thr His His Ala Glu Glu Thr Leu Lys Asn Phe Cys Arg Trp 
    290                 295                 300                 


Gln Lys Asn Ile Asn Ile Lys Gly Asp Asp His Pro Gln His His Asp 
305                 310                 315                 320 


Thr Ala Ile Leu Leu Thr Arg Lys Asp Leu Cys Ala Ser Met Asn Gln 
                325                 330                 335     


Pro Cys Glu Thr Leu Gly Leu Ser His Val Ser Gly Leu Cys His Pro 
            340                 345                 350         


Gln Leu Ser Cys Ser Val Ser Glu Asp Thr Gly Met Pro Leu Ala Phe 
        355                 360                 365             


Thr Val Ala His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly 
    370                 375                 380                 


Thr Gly Asn Asp Cys Glu Ser Ile Gly Lys Arg Pro Phe Ile Met Ser 
385                 390                 395                 400 


Pro Gln Leu Leu Tyr Asp Arg Gly Ile Pro Leu Thr Trp Ser Arg Cys 
                405                 410                 415     


Ser Arg Glu Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys 
            420                 425                 430         


Leu Asp Asp Arg Pro Ser Lys Asp Val Ile Ala Leu Pro Ser Val Leu 
        435                 440                 445             


Pro Gly Val Leu Tyr Asp Val Asn His Gln Cys Arg Leu Gln Tyr Gly 
    450                 455                 460                 


Ser His Ser Ala Tyr Cys Glu Asp Met Asp Asp Val Cys His Thr Leu 
465                 470                 475                 480 


Trp Cys Ser Val Gly Thr Thr Cys His Ser Lys Leu Asp Ala Ala Val 
                485                 490                 495     


Asp Gly Thr Ser Cys Gly Lys Asn Lys Trp Cys Leu Lys Gly Glu Cys 
            500                 505                 510         


Val Pro Glu Gly Phe Gln Pro Glu Ala Val Asp Gly Gly Trp Ser Gly 
        515                 520                 525             


Trp Ser Ala Trp Ser Asp Cys Ser Arg Ser Cys Gly Val Gly Val Arg 
    530                 535                 540                 


Ser Ser Glu Arg Gln Cys Thr Gln Pro Val Pro Lys Asn Arg Gly Lys 
545                 550                 555                 560 


Tyr Cys Val Gly Glu Arg Lys Arg Ser Gln Leu Cys Asn Leu Pro Ala 
                565                 570                 575     


Cys Pro Pro Asp Arg Pro Ser Phe Arg His Thr Gln Cys Ser Gln Phe 
            580                 585                 590         


Asp Gly Met Leu Tyr Lys Gly Lys Leu His Lys Trp Val Pro Val Pro 
        595                 600                 605             


Asn Asp Asp Asn Pro Cys Glu Leu His Cys Arg Pro Ser Asn Ser Ser 
    610                 615                 620                 


Asn Thr Glu Lys Leu Arg Asp Ala Val Val Asp Gly Thr Pro Cys Tyr 
625                 630                 635                 640 


Gln Ser Arg Ile Ser Arg Asp Ile Cys Leu Asn Gly Ile Cys Lys Asn 
                645                 650                 655     


Val Gly Cys Asp Phe Val Ile Asp Ser Gly Ala Glu Glu Asp Arg Cys 
            660                 665                 670         


Gly Val Cys Arg Gly Asp Gly Ser Thr Cys Gln Thr Val Ser Arg Thr 
        675                 680                 685             


Phe Lys Glu Thr Glu Gly Gln Gly Tyr Val Asp Ile Gly Leu Ile Pro 
    690                 695                 700                 


Ala Gly Ala Arg Glu Ile Leu Ile Glu Glu Val Ala Glu Ala Ala Asn 
705                 710                 715                 720 


Phe Leu Ala Leu Arg Ser Glu Asp Pro Asp Lys Tyr Phe Leu Asn Gly 
                725                 730                 735     


Gly Trp Thr Ile Gln Trp Asn Gly Asp Tyr Arg Val Ala Gly Thr Thr 
            740                 745                 750         


Phe Thr Tyr Ala Arg Lys Gly Asn Trp Glu Asn Leu Thr Ser Pro Gly 
        755                 760                 765             


Pro Thr Ser Glu Pro Val Trp Ile Gln Leu Leu Phe Gln Glu Lys Asn 
    770                 775                 780                 


Pro Gly Val His Tyr Gln Tyr Thr Ile Gln Arg Asp Ser His Asp Gln 
785                 790                 795                 800 


Val Arg Pro Pro Glu Phe Ser Trp His Tyr Gly Pro Trp Ser Lys Cys 
                805                 810                 815     


Thr Val Thr Cys Gly Thr Gly Val Gln Arg Gln Ser Leu Tyr Cys Met 
            820                 825                 830         


Glu Arg Gln Ala Gly Val Val Ala Glu Glu Tyr Cys Asn Thr Leu Asn 
        835                 840                 845             


Arg Pro Asp Glu Arg Gln Arg Lys Cys Ser Glu Glu Pro Cys Pro Pro 
    850                 855                 860                 


Arg Trp Trp Ala Gly Glu Trp Gln Pro Cys Ser Arg Ser Cys Gly Pro 
865                 870                 875                 880 


Glu Gly Leu Ser Arg Arg Ala Val Phe Cys Ile Arg Ser Met Gly Leu 
                885                 890                 895     


Asp Glu Gln Arg Ala Leu Glu Leu Ser Ala Cys Glu His Leu Pro Arg 
            900                 905                 910         


Pro Leu Ala Glu Thr Pro Cys Asn Arg His Val Ile Cys Pro Ser Thr 
        915                 920                 925             


Trp Gly Val Gly Asn Trp Ser Gln Cys Ser Val Thr Cys Gly Ala Gly 
    930                 935                 940                 


Ile Arg Gln Arg Ser Val Leu Cys Ile Asn Asn Thr Asp Val Pro Cys 
945                 950                 955                 960 


Asp Glu Ala Glu Arg Pro Ile Thr Glu Thr Phe Cys Phe Leu Gln Pro 
                965                 970                 975     


Cys Gln Tyr Pro Met Tyr Ile Val Asp Thr Gly Ala Ser Gly Ser Gly 
            980                 985                 990         


Ser Ser Ser Pro Glu Leu Phe Asn  Glu Val Asp Phe Ile  Pro Asn Gln 
        995                 1000                 1005             


Leu Ala  Pro Arg Pro Ser Pro  Ala Ser Ser Pro Lys  Pro Val Ser 
    1010                 1015                 1020             


Ile Ser  Asn Ala Ile Asp Glu  Glu Glu Leu Asp Pro  Pro Gly Pro 
    1025                 1030                 1035             


Val Phe  Val Asp Asp Phe Tyr  Tyr Asp Tyr Asn Phe  Ile Asn Phe 
    1040                 1045                 1050             


His Glu  Asp Leu Ser Tyr Gly  Ser Phe Glu Glu Pro  His Pro Asp 
    1055                 1060                 1065             


Leu Val  Asp Asn Gly Gly Trp  Thr Ala Pro Pro His  Ile Arg Pro 
    1070                 1075                 1080             


Thr Glu  Ser Pro Ser Asp Thr  Pro Val Pro Thr Ala  Gly Ala Leu 
    1085                 1090                 1095             


Gly Ala  Glu Ala Glu Asp Ile  Gln Gly Ser Trp Ser  Pro Ser Pro 
    1100                 1105                 1110             


Leu Leu  Ser Glu Ala Ser Tyr  Ser Pro Pro Gly Leu  Glu Gln Thr 
    1115                 1120                 1125             


Ser Ile  Asn Pro Leu Ala Asn  Phe Leu Thr Glu Glu  Asp Thr Pro 
    1130                 1135                 1140             


Met Gly  Ala Pro Glu Leu Gly  Phe Pro Ser Leu Pro  Trp Pro Pro 
    1145                 1150                 1155             


Ala Ser  Val Asp Asp Met Met  Thr Pro Val Gly Pro  Gly Asn Pro 
    1160                 1165                 1170             


Asp Glu  Leu Leu Val Lys Glu  Asp Glu Gln Ser Pro  Pro Ser Thr 
    1175                 1180                 1185             


Pro Trp  Ser Asp Arg Asn Lys  Leu Ser Thr Asp Gly  Asn Pro Leu 
    1190                 1195                 1200             


Gly His  Thr Ser Pro Ala Leu  Pro Gln Ser Pro Ile  Pro Thr Gln 
    1205                 1210                 1215             


Pro Ser  Pro Pro Ser Ile Ser  Pro Thr Gln Ala Ser  Pro Ser Pro 
    1220                 1225                 1230             


Asp Val  Val Glu Val Ser Thr  Gly Trp Asn Ala Ala  Trp Asp Pro 
    1235                 1240                 1245             


Val Leu  Glu Ala Asp Leu Lys  Pro Gly His Gly Glu  Leu Pro Ser 
    1250                 1255                 1260             


Thr Val  Glu Val Ala Ser Pro  Pro Leu Leu Pro Met  Ala Thr Val 
    1265                 1270                 1275             


Pro Gly  Ile Trp Gly Arg Asp  Ser Pro Leu Glu Pro  Gly Thr Pro 
    1280                 1285                 1290             


Thr Phe  Ser Ser Pro Glu Leu  Ser Ser Gln His Leu  Lys Thr Leu 
    1295                 1300                 1305             


Thr Met  Pro Gly Thr Leu Leu  Leu Thr Val Pro Thr  Asp Leu Arg 
    1310                 1315                 1320             


Ser Pro  Gly Pro Ser Gly Gln  Pro Gln Thr Pro Asn  Leu Glu Gly 
    1325                 1330                 1335             


Thr Gln  Ser Pro Gly Leu Leu  Pro Thr Pro Ala Arg  Glu Thr Gln 
    1340                 1345                 1350             


Thr Asn  Ser Ser Lys Asp Pro  Glu Val Gln Pro Leu  Gln Pro Ser 
    1355                 1360                 1365             


Leu Glu  Glu Asp Gly Asp Pro  Ala Asp Pro Leu Pro  Ala Arg Asn 
    1370                 1375                 1380             


Ala Ser  Trp Gln Val Gly Asn  Trp Ser Gln Cys Ser  Thr Thr Cys 
    1385                 1390                 1395             


Gly Leu  Gly Ala Ile Trp Arg  Leu Val Ser Cys Ser  Ser Gly Asn 
    1400                 1405                 1410             


Asp Glu  Asp Cys Thr Leu Ala  Ser Arg Pro Gln Pro  Ala Arg His 
    1415                 1420                 1425             


Cys His  Leu Arg Pro Cys Ala  Ala Trp Arg Thr Gly  Asn Trp Ser 
    1430                 1435                 1440             


Lys Cys  Ser Arg Asn Cys Gly  Gly Gly Ser Ser Thr  Arg Asp Val 
    1445                 1450                 1455             


Gln Cys  Val Asp Thr Arg Asp  Leu Arg Pro Leu Arg  Pro Phe His 
    1460                 1465                 1470             


Cys Gln  Pro Gly Pro Thr Lys  Pro Pro Asn Arg Gln  Leu Cys Gly 
    1475                 1480                 1485             


Thr Gln  Pro Cys Leu Pro Trp  Tyr Thr Ser Ser Trp  Arg Glu Cys 
    1490                 1495                 1500             


Ser Glu  Ala Cys Gly Gly Gly  Glu Gln Gln Arg Leu  Val Thr Cys 
    1505                 1510                 1515             


Pro Glu  Pro Gly Leu Cys Glu  Glu Ser Leu Arg Pro  Asn Asn Ser 
    1520                 1525                 1530             


Arg Pro  Cys Asn Thr His Pro  Cys Thr Gln Trp Val  Val Gly Pro 
    1535                 1540                 1545             


Trp Gly  Gln Cys Ser Ala Pro  Cys Gly Gly Gly Val  Gln Arg Arg 
    1550                 1555                 1560             


Leu Val  Arg Cys Val Asn Thr  Gln Thr Gly Leu Ala  Glu Glu Asp 
    1565                 1570                 1575             


Ser Asp  Leu Cys Ser His Glu  Ala Trp Pro Glu Ser  Ser Arg Pro 
    1580                 1585                 1590             


Cys Ala  Thr Glu Asp Cys Glu  Leu Val Glu Pro Pro  Arg Cys Glu 
    1595                 1600                 1605             


Arg Asp  Arg Leu Ser Phe Asn  Phe Cys Glu Thr Leu  Arg Leu Leu 
    1610                 1615                 1620             


Gly Arg  Cys Gln Leu Pro Thr  Ile Arg Ala Gln Cys  Cys Arg Ser 
    1625                 1630                 1635             


Cys Pro  Pro Leu Ser Arg Gly  Val Pro Ser Arg Gly  His Gln Arg 
    1640                 1645                 1650             


Val Ala  Arg Arg 
    1655         


<210>  24
<211>  1594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS12 from P58397

<400>  24

Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr Cys 
        195                 200                 205             


Gly Leu Lys Asp Ser Val Asn Ile Ser Gln Lys Gln Glu Leu Trp Arg 
    210                 215                 220                 


Glu Lys Trp Glu Arg His Asn Leu Pro Ser Arg Ser Leu Ser Arg Arg 
225                 230                 235                 240 


Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val Val Ala Asp Thr 
                245                 250                 255     


Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu Ser Tyr Ile Leu 
            260                 265                 270         


Thr Ile Met Asn Met Val Thr Gly Leu Phe His Asn Pro Ser Ile Gly 
        275                 280                 285             


Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu Leu Glu Glu Glu 
    290                 295                 300                 


Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys Thr Leu Ser Ser 
305                 310                 315                 320 


Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser Asp Leu Asn Pro 
                325                 330                 335     


Val His His Asp Val Ala Val Leu Leu Thr Arg Lys Asp Ile Cys Ala 
            340                 345                 350         


Gly Phe Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser His Leu Ser Gly 
        355                 360                 365             


Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu Asp Ser Gly Leu 
    370                 375                 380                 


Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His Ser Phe Gly Ile 
385                 390                 395                 400 


Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val Gly Arg His Pro 
                405                 410                 415     


Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Thr Pro Leu Thr Trp 
            420                 425                 430         


Ser Lys Cys Ser Glu Glu Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp 
        435                 440                 445             


Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly Leu Lys Ser Lys 
    450                 455                 460                 


Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His Gln Cys Gln Leu 
465                 470                 475                 480 


Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val Glu Asn Val Cys 
                485                 490                 495     


Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg Ser Lys Leu Asp 
            500                 505                 510         


Ala Ala Ala Asp Gly Thr Gln Cys Gly Glu Lys Lys Trp Cys Met Ala 
        515                 520                 525             


Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser Ile Pro Gly Gly 
    530                 535                 540                 


Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg Thr Cys Gly Ala 
545                 550                 555                 560 


Gly Val Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro Glu Pro Lys Phe 
                565                 570                 575     


Gly Gly Lys Tyr Cys Thr Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn 
            580                 585                 590         


Val His Pro Cys Arg Ser Glu Ala Pro Thr Phe Arg Gln Met Gln Cys 
        595                 600                 605             


Ser Glu Phe Asp Thr Val Pro Tyr Lys Asn Glu Leu Tyr His Trp Phe 
    610                 615                 620                 


Pro Ile Phe Asn Pro Ala His Pro Cys Glu Leu Tyr Cys Arg Pro Ile 
625                 630                 635                 640 


Asp Gly Gln Phe Ser Glu Lys Met Leu Asp Ala Val Ile Asp Gly Thr 
                645                 650                 655     


Pro Cys Phe Glu Gly Gly Asn Ser Arg Asn Val Cys Ile Asn Gly Ile 
            660                 665                 670         


Cys Lys Met Val Gly Cys Asp Tyr Glu Ile Asp Ser Asn Ala Thr Glu 
        675                 680                 685             


Asp Arg Cys Gly Val Cys Leu Gly Asp Gly Ser Ser Cys Gln Thr Val 
    690                 695                 700                 


Arg Lys Met Phe Lys Gln Lys Glu Gly Ser Gly Tyr Val Asp Ile Gly 
705                 710                 715                 720 


Leu Ile Pro Lys Gly Ala Arg Asp Ile Arg Val Met Glu Ile Glu Gly 
                725                 730                 735     


Ala Gly Asn Phe Leu Ala Ile Arg Ser Glu Asp Pro Glu Lys Tyr Tyr 
            740                 745                 750         


Leu Asn Gly Gly Phe Ile Ile Gln Trp Asn Gly Asn Tyr Lys Leu Ala 
        755                 760                 765             


Gly Thr Val Phe Gln Tyr Asp Arg Lys Gly Asp Leu Glu Lys Leu Met 
    770                 775                 780                 


Ala Thr Gly Pro Thr Asn Glu Ser Val Trp Ile Gln Leu Leu Phe Gln 
785                 790                 795                 800 


Val Thr Asn Pro Gly Ile Lys Tyr Glu Tyr Thr Ile Gln Lys Asp Gly 
                805                 810                 815     


Leu Asp Asn Asp Val Glu Gln Gln Met Tyr Phe Trp Gln Tyr Gly His 
            820                 825                 830         


Trp Thr Glu Cys Ser Val Thr Cys Gly Thr Gly Ile Arg Arg Gln Thr 
        835                 840                 845             


Ala His Cys Ile Lys Lys Gly Arg Gly Met Val Lys Ala Thr Phe Cys 
    850                 855                 860                 


Asp Pro Glu Thr Gln Pro Asn Gly Arg Gln Lys Lys Cys His Glu Lys 
865                 870                 875                 880 


Ala Cys Pro Pro Arg Trp Trp Ala Gly Glu Trp Glu Ala Cys Ser Ala 
                885                 890                 895     


Thr Cys Gly Pro His Gly Glu Lys Lys Arg Thr Val Leu Cys Ile Gln 
            900                 905                 910         


Thr Met Val Ser Asp Glu Gln Ala Leu Pro Pro Thr Asp Cys Gln His 
        915                 920                 925             


Leu Leu Lys Pro Lys Thr Leu Leu Ser Cys Asn Arg Asp Ile Leu Cys 
    930                 935                 940                 


Pro Ser Asp Trp Thr Val Gly Asn Trp Ser Glu Cys Ser Val Ser Cys 
945                 950                 955                 960 


Gly Gly Gly Val Arg Ile Arg Ser Val Thr Cys Ala Lys Asn His Asp 
                965                 970                 975     


Glu Pro Cys Asp Val Thr Arg Lys Pro Asn Ser Arg Ala Leu Cys Gly 
            980                 985                 990         


Leu Gln Gln Cys Pro Ser Ser Arg  Arg Val Leu Lys Pro  Asn Lys Gly 
        995                 1000                 1005             


Thr Ile  Ser Asn Gly Lys Asn  Pro Pro Thr Leu Lys  Pro Val Pro 
    1010                 1015                 1020             


Pro Pro  Thr Ser Arg Pro Arg  Met Leu Thr Thr Pro  Thr Gly Pro 
    1025                 1030                 1035             


Glu Ser  Met Ser Thr Ser Thr  Pro Ala Ile Ser Ser  Pro Ser Pro 
    1040                 1045                 1050             


Thr Thr  Ala Ser Lys Glu Gly  Asp Leu Gly Gly Lys  Gln Trp Gln 
    1055                 1060                 1065             


Asp Ser  Ser Thr Gln Pro Glu  Leu Ser Ser Arg Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Thr Gly  Ser Thr Ser Gln Pro  Ile Leu Thr Ser Gln  Ser Leu Ser 
    1085                 1090                 1095             


Ile Gln  Pro Ser Glu Glu Asn  Val Ser Ser Ser Asp  Thr Gly Pro 
    1100                 1105                 1110             


Thr Ser  Glu Gly Gly Leu Val  Ala Thr Thr Thr Ser  Gly Ser Gly 
    1115                 1120                 1125             


Leu Ser  Ser Ser Arg Asn Pro  Ile Thr Trp Pro Val  Thr Pro Phe 
    1130                 1135                 1140             


Tyr Asn  Thr Leu Thr Lys Gly  Pro Glu Met Glu Ile  His Ser Gly 
    1145                 1150                 1155             


Ser Gly  Glu Glu Arg Glu Gln  Pro Glu Asp Lys Asp  Glu Ser Asn 
    1160                 1165                 1170             


Pro Val  Ile Trp Thr Lys Ile  Arg Val Pro Gly Asn  Asp Ala Pro 
    1175                 1180                 1185             


Val Glu  Ser Thr Glu Met Pro  Leu Ala Pro Pro Leu  Thr Pro Asp 
    1190                 1195                 1200             


Leu Ser  Arg Glu Ser Trp Trp  Pro Pro Phe Ser Thr  Val Met Glu 
    1205                 1210                 1215             


Gly Leu  Leu Pro Ser Gln Arg  Pro Thr Thr Ser Glu  Thr Gly Thr 
    1220                 1225                 1230             


Pro Arg  Val Glu Gly Met Val  Thr Glu Lys Pro Ala  Asn Thr Leu 
    1235                 1240                 1245             


Leu Pro  Leu Gly Gly Asp His  Gln Pro Glu Pro Ser  Gly Lys Thr 
    1250                 1255                 1260             


Ala Asn  Arg Asn His Leu Lys  Leu Pro Asn Asn Met  Asn Gln Thr 
    1265                 1270                 1275             


Lys Ser  Ser Glu Pro Val Leu  Thr Glu Glu Asp Ala  Thr Ser Leu 
    1280                 1285                 1290             


Ile Thr  Glu Gly Phe Leu Leu  Asn Ala Ser Asn Tyr  Lys Gln Leu 
    1295                 1300                 1305             


Thr Asn  Gly His Gly Ser Ala  His Trp Ile Val Gly  Asn Trp Ser 
    1310                 1315                 1320             


Glu Cys  Ser Thr Thr Cys Gly  Leu Gly Ala Tyr Trp  Arg Arg Val 
    1325                 1330                 1335             


Glu Cys  Ser Thr Gln Met Asp  Ser Asp Cys Ala Ala  Ile Gln Arg 
    1340                 1345                 1350             


Pro Asp  Pro Ala Lys Arg Cys  His Leu Arg Pro Cys  Ala Gly Trp 
    1355                 1360                 1365             


Lys Val  Gly Asn Trp Ser Lys  Cys Ser Arg Asn Cys  Ser Gly Gly 
    1370                 1375                 1380             


Phe Lys  Ile Arg Glu Ile Gln  Cys Val Asp Ser Arg  Asp His Arg 
    1385                 1390                 1395             


Asn Leu  Arg Pro Phe His Cys  Gln Phe Leu Ala Gly  Ile Pro Pro 
    1400                 1405                 1410             


Pro Leu  Ser Met Ser Cys Asn  Pro Glu Pro Cys Glu  Ala Trp Gln 
    1415                 1420                 1425             


Val Glu  Pro Trp Ser Gln Cys  Ser Arg Ser Cys Gly  Gly Gly Val 
    1430                 1435                 1440             


Gln Glu  Arg Gly Val Phe Cys  Pro Gly Gly Leu Cys  Asp Trp Thr 
    1445                 1450                 1455             


Lys Arg  Pro Thr Ser Thr Met  Ser Cys Asn Glu His  Leu Cys Cys 
    1460                 1465                 1470             


His Trp  Ala Thr Gly Asn Trp  Asp Leu Cys Ser Thr  Ser Cys Gly 
    1475                 1480                 1485             


Gly Gly  Phe Gln Lys Arg Thr  Val Gln Cys Val Pro  Ser Glu Gly 
    1490                 1495                 1500             


Asn Lys  Thr Glu Asp Gln Asp  Gln Cys Leu Cys Asp  His Lys Pro 
    1505                 1510                 1515             


Arg Pro  Pro Glu Phe Lys Lys  Cys Asn Gln Gln Ala  Cys Lys Lys 
    1520                 1525                 1530             


Ser Ala  Asp Leu Leu Cys Thr  Lys Asp Lys Leu Ser  Ala Ser Phe 
    1535                 1540                 1545             


Cys Gln  Thr Leu Lys Ala Met  Lys Lys Cys Ser Val  Pro Thr Val 
    1550                 1555                 1560             


Arg Ala  Glu Cys Cys Phe Ser  Cys Pro Gln Thr His  Ile Thr His 
    1565                 1570                 1575             


Thr Gln  Arg Gln Arg Arg Gln  Arg Leu Leu Gln Lys  Ser Lys Glu 
    1580                 1585                 1590             


Leu 
    


<210>  25
<211>  1599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat ADAMTS12 from D3ZTJ3

<400>  25

Met Pro Cys Ala Gln Gly Asn Trp Met Ala Lys Leu Ser Met Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Phe Cys His Gly Arg Gln Ala Gln Pro 
            20                  25                  30          


Trp Pro Val Arg Phe Pro Asp Pro Lys Gln Glu His Phe Ile Lys Ser 
        35                  40                  45              


Leu Pro Glu Tyr His Ile Val Ser Pro Val Gln Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His His Pro Val Thr Gly Ser Arg Lys 
65                  70                  75                  80  


Lys Arg Ala Ala Gly Gly Ser Gly Asp Gln Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asn Leu Phe Phe Asn Leu Thr Val Asn Trp Glu Phe 
            100                 105                 110         


Leu Ser Asn Gly Tyr Val Val Glu Arg Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Ala Ala Ser Ser Gly Gln Pro Cys His Leu Arg Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Pro Thr Ile Arg Met Gly Thr Ala Ala Leu Ser 
145                 150                 155                 160 


Ala Cys Gln Gly Leu Thr Gly Phe Phe His Leu Pro His Gly Asp Phe 
                165                 170                 175     


Phe Ile Glu Pro Val Lys Lys His Pro Leu Thr Glu Glu Gly Tyr Gln 
            180                 185                 190         


Pro His Val Ile Tyr Arg Arg Gln Ser Tyr Arg Val Pro Glu Thr Lys 
        195                 200                 205             


Glu Pro Thr Cys Gly Leu Lys Asp Ser Leu Asp Asn Ser Val Lys Gln 
    210                 215                 220                 


Glu Leu Gln Arg Glu Lys Trp Glu Arg Lys Asn Trp Pro Ser Arg Ser 
225                 230                 235                 240 


Leu Ser Arg Arg Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Thr Lys Met Val Glu Tyr His Gly Ser Glu Asn Val Glu 
            260                 265                 270         


Ser Tyr Ile Leu Thr Ile Met Asn Met Val Thr Gly Leu Phe His Asn 
        275                 280                 285             


Pro Ser Ile Gly Asn Ala Val His Ile Val Val Val Arg Leu Ile Leu 
    290                 295                 300                 


Leu Glu Glu Glu Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys 
305                 310                 315                 320 


Thr Leu Ser Ser Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser 
                325                 330                 335     


Asp Leu Asn Pro Val His His Asp Val Ala Val Leu Ile Thr Arg Lys 
            340                 345                 350         


Asp Ile Cys Ala Gly Val Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser 
        355                 360                 365             


Gln Leu Ser Gly Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu 
    370                 375                 380                 


Asp Ser Gly Leu Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His 
385                 390                 395                 400 


Ser Phe Gly Ile Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val 
                405                 410                 415     


Gly Arg His Pro Tyr Ile Met Ser Gln Gln Ile Gln Tyr Asp Pro Thr 
            420                 425                 430         


Pro Leu Thr Trp Ser Lys Cys Ser Lys Glu Tyr Ile Thr Arg Phe Leu 
        435                 440                 445             


Asp Arg Gly Arg Gly Phe Cys Leu Asp Asp Val Pro Arg Lys Lys Gly 
    450                 455                 460                 


Leu Lys Ser Asn Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His 
465                 470                 475                 480 


Gln Cys Gln Leu Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val 
                485                 490                 495     


Glu Asn Val Cys Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg 
            500                 505                 510         


Ser Lys Leu Asp Ala Ala Ala Asp Gly Thr Arg Cys Gly Glu Lys Lys 
        515                 520                 525             


Trp Cys Met Ala Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser 
    530                 535                 540                 


Ile Pro Gly Gly Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg 
545                 550                 555                 560 


Thr Cys Gly Ala Gly Ala Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro 
                565                 570                 575     


Glu Pro Lys Phe Gly Gly Lys Tyr Cys Thr Gly Glu Arg Lys Arg Tyr 
            580                 585                 590         


Arg Leu Cys Asn Val His Pro Cys Arg Ser Asp Thr Pro Thr Phe Arg 
        595                 600                 605             


Gln Met Gln Cys Ser Glu Phe Asp Thr Val Pro Tyr Lys Asn Gln Phe 
    610                 615                 620                 


Tyr Arg Trp Phe Pro Val Phe Asn Pro Ala His Pro Cys Glu Leu Tyr 
625                 630                 635                 640 


Cys Arg Pro Ile Asp Glu Gln Phe Ser Glu Arg Met Leu Glu Ala Val 
                645                 650                 655     


Ile Asp Gly Thr Pro Cys Phe Glu Gly Gly Asn Ser Arg Asn Val Cys 
            660                 665                 670         


Ile Asn Gly Ile Cys Lys Arg Val Gly Cys Asp Tyr Glu Ile Asp Ser 
        675                 680                 685             


Asn Ala Thr Glu Asp Arg Cys Gly Val Cys Leu Gly Asp Gly Ser Ala 
    690                 695                 700                 


Cys Gln Thr Val Lys Lys Val Phe Arg Gln Lys Glu Gly Ser Gly Tyr 
705                 710                 715                 720 


Ile Asp Ile Gly Leu Ile Pro Lys Gly Ala Arg Asp Ile Arg Val Met 
                725                 730                 735     


Glu Ile Lys Ala Ala Gly Asn Phe Leu Ala Ile Arg Ser Glu Asp Pro 
            740                 745                 750         


Glu Lys Tyr Tyr Leu Asn Gly Gly Phe Ile Ile Gln Trp Asn Gly Asn 
        755                 760                 765             


Tyr Lys Leu Ala Gly Thr Val Phe Gln Tyr Asp Arg Lys Gly Asp Leu 
    770                 775                 780                 


Glu Arg Leu Met Ala Pro Gly Pro Thr Asn Glu Ser Val Trp Leu Gln 
785                 790                 795                 800 


Leu Leu Phe Gln Val Thr Asn Pro Gly Ile Lys Tyr Glu Tyr Thr Val 
                805                 810                 815     


Arg Lys Asp Gly Leu Asp Asn Asp Val Glu Lys Leu Leu Tyr Phe Trp 
            820                 825                 830         


Gln Phe Gly Arg Trp Thr Glu Cys Ser Val Thr Cys Gly Thr Gly Ile 
        835                 840                 845             


Arg Arg Gln Thr Ala His Cys Val Lys Lys Gly His Gly Ile Val Lys 
    850                 855                 860                 


Thr Thr Phe Cys Asn Pro Glu Thr Gln Pro Ser Val Arg Gln Lys Lys 
865                 870                 875                 880 


Cys Tyr Glu Lys Asp Cys Pro Pro Arg Trp Trp Ala Gly Glu Trp Glu 
                885                 890                 895     


Ala Cys Ser Met Thr Cys Gly Pro Tyr Gly Glu Lys Lys Arg Thr Val 
            900                 905                 910         


Leu Cys Ile Gln Thr Met Gly Ser Asp Glu Gln Ala Leu Pro Ala Thr 
        915                 920                 925             


Asp Cys Gln His Leu Leu Lys Pro Lys Thr Leu Val Ser Cys Asn Arg 
    930                 935                 940                 


Asp Ile Leu Cys Pro Ser Asp Trp Thr Val Gly Asn Trp Ser Glu Cys 
945                 950                 955                 960 


Ser Val Ser Cys Gly Gly Gly Val Arg Ile Arg Ser Val Thr Cys Ala 
                965                 970                 975     


Lys Asn Leu Asn Glu Pro Cys Asp Lys Thr Arg Lys Pro Asn Ser Arg 
            980                 985                 990         


Ala Leu Cys Gly Leu Gln Gln Cys  Pro Phe Ser Arg Arg  Val Leu Lys 
        995                 1000                 1005             


Pro Asn  Lys Asp Thr Val Pro  Ser Gly Lys Asn Pro  Thr Thr Ser 
    1010                 1015                 1020             


Glu His  Asp His Phe Lys Pro  Ile Pro Ala Ser Thr  Ser Arg Pro 
    1025                 1030                 1035             


Thr Pro  Leu Ser Thr Pro Thr  Val Pro Glu Ser Val  Ser Thr Ser 
    1040                 1045                 1050             


Thr Pro  Thr Ile Asn Ser Leu  Gly Ser Thr Ile Thr  Ser Gln Glu 
    1055                 1060                 1065             


Glu Pro  Asp Gly Ile Gly Trp  Gln Asn Asn Ser Thr  Gln Ala Glu 
    1070                 1075                 1080             


Glu Asp  Ser His Ile Pro Thr  Ser Val Gly Ser Thr  Ser Gln Thr 
    1085                 1090                 1095             


Pro Leu  Thr Ser Trp Ser Trp  Ser Met Gln Pro Asp  Asp Glu Asn 
    1100                 1105                 1110             


Val Ser  Ser Ser Ala Ile Gly  Pro Thr Ser Glu Ser  Asp Phe Trp 
    1115                 1120                 1125             


Ala Thr  Thr Ser Asp Ser Gly  Leu Ser Ser Ser Asn  Ala Met Thr 
    1130                 1135                 1140             


Trp Gln  Val Thr Pro Phe Tyr  Ser Thr Ala Thr Thr  Glu Pro Glu 
    1145                 1150                 1155             


Val Glu  Ile His Ser Gly Ser  Gly Glu Asp Ser Asp  Gln Pro Leu 
    1160                 1165                 1170             


Asn Lys  Glu Glu Asn Asn Ser  Val Leu Trp Asn Lys  Ile Arg Val 
    1175                 1180                 1185             


Pro Glu  Arg Asp Ala Pro Met  Glu Met Asp Ala Glu  Ile Pro Leu 
    1190                 1195                 1200             


Gly Pro  Pro Pro Thr Ser Tyr  Val Thr Glu Glu Ser  Ser Trp Pro 
    1205                 1210                 1215             


Pro Phe  Ser Thr Met Met Lys  Ser Ser Leu Pro Ala  Trp Ser Phe 
    1220                 1225                 1230             


Lys Asn  Glu Thr Pro Arg Asp  Glu Gly Met Ile Thr  Glu Lys Ser 
    1235                 1240                 1245             


Gly Asn  Ile Pro Leu Pro Leu  Gly Gly Asp His Gln  Thr Thr Ser 
    1250                 1255                 1260             


Pro Glu  Lys Leu Gly Asn Asn  Asp Gln Leu Ala Ser  Ala Asn Ser 
    1265                 1270                 1275             


Thr Asn  Pro Thr Gln Gly Ser  Gly Pro Val Leu Thr  Glu Glu Asp 
    1280                 1285                 1290             


Ala Ser  Thr Leu Ile Glu Glu  Gly Phe Leu Leu Asn  Ala Ser Asn 
    1295                 1300                 1305             


Tyr Lys  His Leu Met Lys Asp  His Ser Pro Ala His  Trp Ile Val 
    1310                 1315                 1320             


Gly Asn  Trp Ser Lys Cys Ser  Thr Thr Cys Gly Leu  Gly Ala Tyr 
    1325                 1330                 1335             


Trp Arg  Ser Val Glu Cys Ser  Thr Gly Met Asn Ala  Asp Cys Ala 
    1340                 1345                 1350             


Ala Ile  Gln Arg Pro Asp Pro  Ala Lys Lys Cys His  Leu Arg Pro 
    1355                 1360                 1365             


Cys Ala  Gly Trp Arg Val Gly  Asn Trp Ser Lys Cys  Ser Arg Asn 
    1370                 1375                 1380             


Cys Ser  Gly Gly Phe Lys Ile  Arg Glu Val Gln Cys  Met Asp Gly 
    1385                 1390                 1395             


Val Asp  His His Arg Ser Leu  Arg Pro Phe His Cys  Gln Phe Leu 
    1400                 1405                 1410             


Ala Gly  Val Pro Pro Pro Leu  Ser Met Ser Cys Asn  Leu Glu Pro 
    1415                 1420                 1425             


Cys Glu  Glu Trp Lys Val Glu  Pro Trp Ser Gln Cys  Ser Arg Ser 
    1430                 1435                 1440             


Cys Gly  Gly Gly Val Gln Glu  Arg Gly Val Phe Cys  Pro Gly Gly 
    1445                 1450                 1455             


Leu Cys  Asp Trp Thr Lys Arg  Pro Ala Ser Thr Val  Pro Cys Asn 
    1460                 1465                 1470             


Arg His  Leu Cys Cys His Trp  Ala Thr Gly Asn Trp  Glu Leu Cys 
    1475                 1480                 1485             


Thr Thr  Ser Cys Gly Gly Gly  Ser Gln Lys Arg Thr  Val His Cys 
    1490                 1495                 1500             


Ile Pro  Ser Glu Asn Ser Thr  Thr Glu Asp Gln Asp  Gln Cys Phe 
    1505                 1510                 1515             


Cys Asp  His Gln Ala Arg Pro  Pro Glu Phe Gln Asn  Cys Asn Gln 
    1520                 1525                 1530             


Gln Ala  Cys Arg Lys Ser Ala  Asp Leu Thr Cys Thr  Lys Asp Arg 
    1535                 1540                 1545             


Leu Ser  Thr Ser Phe Cys Gln  Thr Leu Lys Ser Met  Lys Lys Cys 
    1550                 1555                 1560             


Ser Val  Pro Ser Val Arg Val  Gln Cys Cys Leu Ser  Cys Pro Gln 
    1565                 1570                 1575             


Thr Gln  Ser Ile His Thr Gln  Arg Gln Arg Lys Gln  Gln Met Leu 
    1580                 1585                 1590             


Gln Asn  His Asp Thr Leu 
    1595                 


<210>  26
<211>  1600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse ADAMTS12 from Q811B3

<400>  26

Met Pro Cys Ala Arg Gly Ser Trp Leu Ala Lys Leu Ser Ile Val Ala 
1               5                   10                  15      


Gln Leu Ile Asn Phe Gly Ala Phe Cys His Gly Arg Gln Thr Gln Pro 
            20                  25                  30          


Trp Pro Val Arg Phe Pro Asp Pro Arg Gln Glu His Phe Ile Lys Ser 
        35                  40                  45              


Leu Pro Glu Tyr His Ile Val Ser Pro Val Gln Val Asp Ala Gly Gly 
    50                  55                  60                  


His Val Leu Ser Tyr Gly Leu His His Pro Val Thr Ser Ser Arg Lys 
65                  70                  75                  80  


Lys Arg Ala Ala Gly Gly Ser Gly Asp Gln Leu Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Trp Glu Phe 
            100                 105                 110         


Leu Ser Asn Gly Tyr Val Val Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Val Ala Ser Ser Gly Gln Pro Cys His Leu Arg Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Thr Thr Val Gly Ile Gly Thr Ala Ala Leu Ser 
145                 150                 155                 160 


Ala Cys Gln Gly Leu Thr Gly Phe Phe His Leu Pro His Gly Asp Phe 
                165                 170                 175     


Phe Ile Glu Pro Val Lys Lys His Pro Leu Thr Glu Glu Gly Ser Tyr 
            180                 185                 190         


Pro His Val Val Tyr Arg Arg Gln Ser Ile Arg Ala Pro Glu Thr Lys 
        195                 200                 205             


Glu Pro Ile Cys Gly Leu Lys Asp Ser Leu Asp Asn Ser Val Lys Gln 
    210                 215                 220                 


Glu Leu Gln Arg Glu Lys Trp Glu Arg Lys Thr Leu Arg Ser Arg Ser 
225                 230                 235                 240 


Leu Ser Arg Arg Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Thr Lys Thr Val Glu Tyr His Gly Ser Glu Asn Val Glu 
            260                 265                 270         


Ser Tyr Ile Leu Thr Ile Met Asn Met Val Thr Gly Leu Phe His Ser 
        275                 280                 285             


Pro Ser Ile Gly Asn Leu Val His Ile Val Val Val Arg Leu Ile Leu 
    290                 295                 300                 


Leu Glu Glu Glu Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys 
305                 310                 315                 320 


Thr Leu Ser Ser Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser 
                325                 330                 335     


Asp Leu Asn Pro Val His His Asp Val Ala Val Leu Ile Thr Arg Lys 
            340                 345                 350         


Asp Ile Cys Ala Gly Val Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser 
        355                 360                 365             


Gln Leu Ser Gly Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu 
    370                 375                 380                 


Asp Ser Gly Leu Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His 
385                 390                 395                 400 


Ser Phe Gly Ile Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val 
                405                 410                 415     


Gly Arg His Pro Tyr Ile Met Ser Gln Gln Ile Gln Tyr Asp Pro Thr 
            420                 425                 430         


Pro Leu Thr Trp Ser Lys Cys Ser Lys Glu Tyr Ile Thr Arg Phe Leu 
        435                 440                 445             


Asp Arg Gly Arg Gly Phe Cys Leu Asp Asp Ile Pro Ser Lys Lys Gly 
    450                 455                 460                 


Leu Lys Ser Asn Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His 
465                 470                 475                 480 


Gln Cys Gln Leu Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val 
                485                 490                 495     


Glu Asn Val Cys Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg 
            500                 505                 510         


Ser Lys Leu Asp Ala Ala Ala Asp Gly Thr Arg Cys Gly Glu Lys Lys 
        515                 520                 525             


Trp Cys Met Ala Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser 
    530                 535                 540                 


Ile Pro Gly Gly Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg 
545                 550                 555                 560 


Thr Cys Gly Ala Gly Ala Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro 
                565                 570                 575     


Glu Pro Lys Phe Gly Gly Lys Tyr Cys Thr Gly Glu Arg Lys Arg Tyr 
            580                 585                 590         


Arg Leu Cys Asn Val His Pro Cys Arg Ser Asp Thr Pro Thr Phe Arg 
        595                 600                 605             


Gln Met Gln Cys Ser Glu Phe Asp Thr Val Pro Tyr Lys Asn Gln Phe 
    610                 615                 620                 


Tyr Arg Trp Phe Pro Val Phe Asn Ala Ala His Pro Cys Glu Leu Tyr 
625                 630                 635                 640 


Cys Arg Pro Ile Asp Glu Gln Phe Ser Glu Arg Met Leu Glu Ala Val 
                645                 650                 655     


Ile Asp Gly Thr Pro Cys Phe Glu Gly Gly Asn Ser Arg Asn Val Cys 
            660                 665                 670         


Ile Asn Gly Ile Cys Lys Arg Val Gly Cys Asp Tyr Glu Ile Asp Ser 
        675                 680                 685             


Asn Ala Thr Glu Asp Arg Cys Gly Val Cys Leu Gly Asp Gly Ser Ala 
    690                 695                 700                 


Cys Gln Thr Val Lys Lys Leu Phe Arg Gln Lys Glu Gly Ser Gly Tyr 
705                 710                 715                 720 


Val Asp Ile Gly Leu Ile Pro Lys Gly Ala Arg Asp Ile Arg Val Met 
                725                 730                 735     


Glu Ile Lys Ala Ala Gly Asn Phe Leu Ala Ile Arg Ser Glu Asp Pro 
            740                 745                 750         


Glu Lys Tyr Tyr Leu Asn Gly Gly Phe Ile Ile Gln Trp Asn Gly Asn 
        755                 760                 765             


Tyr Lys Leu Ala Gly Thr Val Phe Gln Tyr Asp Arg Lys Gly Asp Leu 
    770                 775                 780                 


Glu Lys Leu Ile Ala Pro Gly Pro Thr Asn Glu Ser Val Trp Leu Gln 
785                 790                 795                 800 


Leu Leu Phe Gln Val Thr Asn Pro Gly Ile Lys Tyr Glu Tyr Thr Val 
                805                 810                 815     


Arg Lys Asp Gly Leu Asp Asn Asp Val Glu Lys Leu Leu Tyr Phe Trp 
            820                 825                 830         


Gln Phe Gly Arg Trp Thr Glu Cys Ser Val Thr Cys Gly Thr Gly Ile 
        835                 840                 845             


Arg Arg Gln Ala Ala His Cys Val Lys Lys Gly His Gly Ile Val Lys 
    850                 855                 860                 


Thr Thr Phe Cys Asn Pro Glu Thr Gln Pro Ser Val Arg Gln Lys Lys 
865                 870                 875                 880 


Cys His Glu Lys Asp Cys Pro Pro Arg Trp Trp Ala Gly Glu Trp Glu 
                885                 890                 895     


Ala Cys Ser Thr Thr Cys Gly Pro Tyr Gly Glu Lys Lys Arg Thr Val 
            900                 905                 910         


Leu Cys Ile Gln Thr Met Gly Ser Asp Glu Gln Ala Leu Pro Ala Thr 
        915                 920                 925             


Asp Cys Gln His Leu Leu Lys Pro Lys Ala Leu Val Ser Cys Asn Arg 
    930                 935                 940                 


Asp Ile Leu Cys Pro Ser Asp Trp Thr Val Gly Asn Trp Ser Glu Cys 
945                 950                 955                 960 


Ser Val Ser Cys Gly Gly Gly Val Arg Ile Arg Ser Val Thr Cys Ala 
                965                 970                 975     


Lys Asn Leu Asn Glu Pro Cys Asp Lys Thr Arg Lys Pro Asn Ser Arg 
            980                 985                 990         


Ala Leu Cys Gly Leu Gln Gln Cys  Pro Phe Ser Arg Arg  Val Leu Lys 
        995                 1000                 1005             


Pro Asn  Lys Asp Ile Ala Pro  Ser Gly Lys Asn Gln  Ser Thr Ala 
    1010                 1015                 1020             


Glu His  Asp Pro Phe Lys Pro  Ile Pro Ala Pro Thr  Ser Arg Pro 
    1025                 1030                 1035             


Thr Pro  Leu Ser Thr Pro Thr  Val Pro Glu Ser Met  Ser Thr Ser 
    1040                 1045                 1050             


Thr Pro  Thr Ile Asn Ser Leu  Gly Ser Thr Ile Ala  Ser Gln Glu 
    1055                 1060                 1065             


Asp Ala  Asn Gly Met Gly Trp  Gln Asn Asn Ser Thr  Gln Ala Glu 
    1070                 1075                 1080             


Glu Gly  Ser His Phe Pro Thr  Ser Ser Gly Ser Thr  Ser Gln Val 
    1085                 1090                 1095             


Pro Val  Thr Ser Trp Ser Leu  Ser Ile Gln Pro Asp  Asp Glu Asn 
    1100                 1105                 1110             


Val Ser  Ser Ser Ala Ile Gly  Pro Thr Ser Glu Gly  Asp Phe Trp 
    1115                 1120                 1125             


Ala Thr  Thr Thr Ser Asp Ser  Gly Leu Ser Ser Ser  Asp Ala Met 
    1130                 1135                 1140             


Thr Trp  Gln Val Thr Pro Phe  Tyr Ser Thr Met Thr  Thr Asp Pro 
    1145                 1150                 1155             


Glu Val  Glu Ile His Ser Gly  Ser Gly Glu Asp Ser  Asp Gln Pro 
    1160                 1165                 1170             


Leu Asn  Lys Asp Lys Ser Asn  Ser Val Ile Trp Asn  Lys Ile Gly 
    1175                 1180                 1185             


Val Pro  Glu His Asp Ala Pro  Met Glu Thr Asp Ala  Glu Leu Pro 
    1190                 1195                 1200             


Leu Gly  Pro Pro Pro Thr Ser  Tyr Met Gly Glu Glu  Pro Ser Trp 
    1205                 1210                 1215             


Pro Pro  Phe Ser Thr Lys Met  Glu Gly Ser Leu Pro  Ala Trp Ser 
    1220                 1225                 1230             


Phe Lys  Asn Glu Thr Pro Arg  Asp Asp Gly Met Ile  Ala Glu Lys 
    1235                 1240                 1245             


Ser Arg  Lys Ile Pro Leu Pro  Leu Ala Gly Asp His  His Pro Ala 
    1250                 1255                 1260             


Thr Ser  Glu Lys Leu Glu Asn  His Asp Lys Leu Ala  Leu Pro Asn 
    1265                 1270                 1275             


Thr Thr  Asn Pro Thr Gln Gly  Phe Gly Pro Val Leu  Thr Glu Glu 
    1280                 1285                 1290             


Asp Ala  Ser Asn Leu Ile Ala  Glu Gly Phe Leu Leu  Asn Ala Ser 
    1295                 1300                 1305             


Asp Tyr  Lys His Leu Met Lys  Asp His Ser Pro Ala  Tyr Trp Ile 
    1310                 1315                 1320             


Val Gly  Asn Trp Ser Lys Cys  Ser Thr Thr Cys Gly  Leu Gly Ala 
    1325                 1330                 1335             


Tyr Trp  Arg Ser Val Glu Cys  Ser Ser Gly Val Asp  Ala Asp Cys 
    1340                 1345                 1350             


Thr Thr  Ile Gln Arg Pro Asp  Pro Ala Lys Lys Cys  His Leu Arg 
    1355                 1360                 1365             


Pro Cys  Ala Gly Trp Arg Val  Gly Asn Trp Ser Lys  Cys Ser Arg 
    1370                 1375                 1380             


Asn Cys  Ser Gly Gly Phe Lys  Ile Arg Glu Val Gln  Cys Met Asp 
    1385                 1390                 1395             


Ser Leu  Asp His His Arg Ser  Leu Arg Pro Phe His  Cys Gln Phe 
    1400                 1405                 1410             


Leu Ala  Gly Ala Pro Pro Pro  Leu Ser Met Ser Cys  Asn Leu Glu 
    1415                 1420                 1425             


Pro Cys  Gly Glu Trp Gln Val  Glu Pro Trp Ser Gln  Cys Ser Arg 
    1430                 1435                 1440             


Ser Cys  Gly Gly Gly Val Gln  Glu Arg Gly Val Ser  Cys Pro Gly 
    1445                 1450                 1455             


Gly Leu  Cys Asp Trp Thr Lys  Arg Pro Ala Thr Thr  Val Pro Cys 
    1460                 1465                 1470             


Asn Arg  His Leu Cys Cys His  Trp Ala Thr Gly Asn  Trp Glu Leu 
    1475                 1480                 1485             


Cys Asn  Thr Ser Cys Gly Gly  Gly Ser Gln Lys Arg  Thr Ile His 
    1490                 1495                 1500             


Cys Ile  Pro Ser Glu Asn Ser  Thr Thr Glu Asp Gln  Asp Gln Cys 
    1505                 1510                 1515             


Leu Cys  Asp His Gln Val Lys  Pro Pro Glu Phe Gln  Thr Cys Asn 
    1520                 1525                 1530             


Gln Gln  Ala Cys Arg Lys Ser  Ala Asp Leu Thr Cys  Leu Lys Asp 
    1535                 1540                 1545             


Arg Leu  Ser Ile Ser Phe Cys  Gln Thr Leu Lys Ser  Met Arg Lys 
    1550                 1555                 1560             


Cys Ser  Val Pro Ser Val Arg  Ala Gln Cys Cys Leu  Ser Cys Pro 
    1565                 1570                 1575             


Gln Ala  Pro Ser Ile His Thr  Gln Arg Gln Arg Lys  Gln Gln Leu 
    1580                 1585                 1590             


Leu Gln  Asn His Asp Met Leu  
    1595                 1600 


<210>  27
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS7 Pro Domain (hADAMTS7_Pro)

<400>  27

Arg Ala Thr Glu Gly Arg Ala Ala Leu Asp Ile Val His Pro Val Arg 
1               5                   10                  15      


Val Asp Ala Gly Gly Ser Phe Leu Ser Tyr Glu Leu Trp Pro Arg Ala 
            20                  25                  30          


Leu Arg Lys Arg Asp Val Ser Val Arg Arg Asp Ala Pro Ala Phe Tyr 
        35                  40                  45              


Glu Leu Gln Tyr Arg Gly Arg Glu Leu Arg Phe Asn Leu Thr Ala Asn 
    50                  55                  60                  


Gln His Leu Leu Ala Pro Gly Phe Val Ser Glu Thr Arg Arg Arg Gly 
65                  70                  75                  80  


Gly Leu Gly Arg Ala His Ile Arg Ala His Thr Pro Ala Cys His Leu 
                85                  90                  95      


Leu Gly Glu Val Gln Asp Pro Glu Leu Glu Gly Gly Leu Ala Ala Ile 
            100                 105                 110         


Ser Ala Cys Asp Gly Leu Lys Gly Val Phe Gln Leu Ser Asn Glu Asp 
        115                 120                 125             


Tyr Phe Ile Glu Pro Leu Asp Ser Ala Pro Ala Arg Pro Gly His Ala 
    130                 135                 140                 


Gln Pro His Val Val Tyr Lys Arg Gln Ala Pro Glu Arg Leu Ala Gln 
145                 150                 155                 160 


Arg Gly Asp Ser Ser Ala Pro Ser Thr Cys Gly Val Gln Val Tyr Pro 
                165                 170                 175     


Glu Leu Glu Ser Arg Arg Glu Arg Trp Glu Gln Arg Gln Gln Trp Arg 
            180                 185                 190         


Arg Pro Arg Leu Arg Arg Leu His Gln Arg 
        195                 200         


<210>  28
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat ADAMTS7 Pro Domain (rADAMTS7_Pro)

<400>  28

Leu Pro Thr Glu Gly Arg Ala Gly Leu Asp Ile Val His Pro Val Arg 
1               5                   10                  15      


Val Asp Ala Gly Gly Ser Phe Leu Ser Tyr Glu Leu Trp Pro Arg Val 
            20                  25                  30          


Leu Arg Lys Arg Asp Val Ser Ala Ala Gln Ala Ser Ser Ala Phe Tyr 
        35                  40                  45              


Gln Leu Gln Tyr Gln Gly Arg Glu Leu Leu Phe Asn Leu Thr Thr Asn 
    50                  55                  60                  


Pro Tyr Leu Leu Ala Pro Gly Phe Val Ser Glu Ile Arg Arg Arg Ser 
65                  70                  75                  80  


Asn Leu Ser Asn Val His Ile Gln Thr Ser Val Pro Thr Cys His Leu 
                85                  90                  95      


Leu Gly Asp Val Gln Asp Pro Glu Leu Glu Gly Gly Phe Ala Ala Ile 
            100                 105                 110         


Ser Ala Cys Asp Gly Leu Arg Gly Val Phe Gln Leu Ser Asn Glu Asp 
        115                 120                 125             


Tyr Phe Ile Glu Pro Leu Asp Glu Val Pro Ala Gln Pro Gly His Ala 
    130                 135                 140                 


Gln Pro His Met Val Tyr Lys His Lys Arg Ser Gly Gln Gln Asp Asp 
145                 150                 155                 160 


Ser Arg Thr Ser Gly Thr Cys Gly Val Gln Gly Ser Pro Glu Leu Lys 
                165                 170                 175     


His Gln Arg Glu His Trp Glu Gln Arg Gln Gln Lys Arg Arg Gln Gln 
            180                 185                 190         


Arg 
    


<210>  29
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ADAMTS7 CD domain (hADAMTS7_CD)

<400>  29

Ser Val Ser Lys Glu Lys Trp Val Glu Thr Leu Val Val Ala Asp Ala 
1               5                   10                  15      


Lys Met Val Glu Tyr His Gly Gln Pro Gln Val Glu Ser Tyr Val Leu 
            20                  25                  30          


Thr Ile Met Asn Met Val Ala Gly Leu Phe His Asp Pro Ser Ile Gly 
        35                  40                  45              


Asn Pro Ile His Ile Thr Ile Val Arg Leu Val Leu Leu Glu Asp Glu 
    50                  55                  60                  


Glu Glu Asp Leu Lys Ile Thr His His Ala Asp Asn Thr Leu Lys Ser 
65                  70                  75                  80  


Phe Cys Lys Trp Gln Lys Ser Ile Asn Met Lys Gly Asp Ala His Pro 
                85                  90                  95      


Leu His His Asp Thr Ala Ile Leu Leu Thr Arg Lys Asp Leu Cys Ala 
            100                 105                 110         


Ala Met Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser His Val Ala Gly 
        115                 120                 125             


Met Cys Gln Pro His Arg Ser Cys Ser Ile Asn Glu Asp Thr Gly Leu 
    130                 135                 140                 


Pro Leu Ala Phe Thr Val Ala His Glu Leu Gly His Ser Phe Gly Ile 
145                 150                 155                 160 


Gln His Asp Gly Ser Gly Asn Asp Cys Glu Pro Val Gly Lys Arg Pro 
                165                 170                 175     


Phe Ile Met Ser Pro Gln Leu Leu Tyr Asp Ala Ala Pro Leu Thr Trp 
            180                 185                 190         


Ser Arg Cys Ser Arg Gln Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp 
        195                 200                 205             


Gly Leu Cys Leu Asp Asp Pro Pro Ala Lys Asp Ile Ile Asp Phe Pro 
    210                 215                 220                 


Ser Val Pro Pro Gly Val Leu Tyr Asp Val Ser His Gln Cys Arg Leu 
225                 230                 235                 240 


Gln Tyr Gly Ala Tyr Ser Ala Phe Cys Glu Asp Met Asp Asn Val Cys 
                245                 250                 255     


His Thr Leu Trp Cys Ser Val Gly Thr Thr Cys His Ser Lys Leu Asp 
            260                 265                 270         


Ala Ala Val Asp Gly Thr Arg Cys Gly Glu Asn Lys Trp Cys Leu Ser 
        275                 280                 285             


Gly Glu Cys Val Pro Val Gly Phe Arg Pro Glu Ala Val 
    290                 295                 300     


<210>  30
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat ADAMTS7 CD domain (rADAMTS7_CD)

<400>  30

Ser Ile Ser Lys Glu Lys Trp Val Glu Thr Leu Val Val Ala Asp Ser 
1               5                   10                  15      


Lys Met Val Glu Tyr His Gly Gln Pro Gln Val Glu Ser Tyr Val Leu 
            20                  25                  30          


Thr Ile Met Asn Met Val Ala Gly Leu Tyr His Asp Pro Ser Ile Gly 
        35                  40                  45              


Asn Pro Ile His Ile Thr Val Val Arg Leu Ile Ile Leu Glu Asp Glu 
    50                  55                  60                  


Glu Lys Asp Leu Lys Ile Thr His His Ala Asp Asp Thr Leu Lys Asn 
65                  70                  75                  80  


Phe Cys Arg Trp Gln Lys Asn Val Asn Met Lys Gly Asp Asp His Pro 
                85                  90                  95      


Gln His His Asp Thr Ala Ile Leu Leu Thr Arg Lys Asp Leu Cys Ala 
            100                 105                 110         


Thr Met Asn His Pro Cys Glu Thr Leu Gly Leu Ser His Val Ala Gly 
        115                 120                 125             


Leu Cys His Pro Gln Leu Ser Cys Ser Val Ser Glu Asp Thr Gly Leu 
    130                 135                 140                 


Pro Leu Ala Phe Thr Val Ala His Glu Leu Gly His Ser Phe Gly Ile 
145                 150                 155                 160 


Gln His Asp Gly Thr Gly Asn Asp Cys Glu Ser Ile Gly Lys Arg Pro 
                165                 170                 175     


Phe Ile Met Ser Pro Gln Leu Leu Tyr Asp Arg Gly Ile Pro Leu Thr 
            180                 185                 190         


Trp Ser Arg Cys Ser Arg Glu Tyr Ile Thr Arg Phe Leu Asp Arg Gly 
        195                 200                 205             


Trp Gly Leu Cys Leu Asp Asp Arg Pro Ser Lys Gly Val Ile Asn Phe 
    210                 215                 220                 


Pro Ser Val Leu Pro Gly Val Leu Tyr Asp Val Asn His Gln Cys Arg 
225                 230                 235                 240 


Leu Gln Tyr Gly Pro Ser Ser Ala Tyr Cys Glu Asp Val Asp Asn Val 
                245                 250                 255     


Cys Tyr Thr Leu Trp Cys Ser Val Gly Thr Thr Cys His Ser Lys Met 
            260                 265                 270         


Asp Ala Ala Val Asp Gly Thr Ser Cys Gly Lys Asn Lys Trp Cys Leu 
        275                 280                 285             


Asn Gly Glu Cys Val Pro Glu Gly Phe Gln Pro Glu Thr Val 
    290                 295                 300         


<210>  31
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rPro-hCD (Rat 1-217/Human 237-537 
       (R58A/R60A/R217A))-TEV-2Strep-6His

<400>  31

Met His Arg Gly Leu Asn Leu Leu Leu Ile Leu Cys Ala Leu Ala Pro 
1               5                   10                  15      


His Val Leu Gly Pro Ala Ser Gly Leu Pro Thr Glu Gly Arg Ala Gly 
            20                  25                  30          


Leu Asp Ile Val His Pro Val Arg Val Asp Ala Gly Gly Ser Phe Leu 
        35                  40                  45              


Ser Tyr Glu Leu Trp Pro Arg Val Leu Ala Lys Ala Asp Val Ser Ala 
    50                  55                  60                  


Ala Gln Ala Ser Ser Ala Phe Tyr Gln Leu Gln Tyr Gln Gly Arg Glu 
65                  70                  75                  80  


Leu Leu Phe Asn Leu Thr Thr Asn Pro Tyr Leu Leu Ala Pro Gly Phe 
                85                  90                  95      


Val Ser Glu Ile Arg Arg Arg Ser Asn Leu Ser Asn Val His Ile Gln 
            100                 105                 110         


Thr Ser Val Pro Thr Cys His Leu Leu Gly Asp Val Gln Asp Pro Glu 
        115                 120                 125             


Leu Glu Gly Gly Phe Ala Ala Ile Ser Ala Cys Asp Gly Leu Arg Gly 
    130                 135                 140                 


Val Phe Gln Leu Ser Asn Glu Asp Tyr Phe Ile Glu Pro Leu Asp Glu 
145                 150                 155                 160 


Val Pro Ala Gln Pro Gly His Ala Gln Pro His Met Val Tyr Lys His 
                165                 170                 175     


Lys Arg Ser Gly Gln Gln Asp Asp Ser Arg Thr Ser Gly Thr Cys Gly 
            180                 185                 190         


Val Gln Gly Ser Pro Glu Leu Lys His Gln Arg Glu His Trp Glu Gln 
        195                 200                 205             


Arg Gln Gln Lys Arg Arg Gln Gln Ala Ser Val Ser Lys Glu Lys Trp 
    210                 215                 220                 


Val Glu Thr Leu Val Val Ala Asp Ala Lys Met Val Glu Tyr His Gly 
225                 230                 235                 240 


Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn Met Val Ala 
                245                 250                 255     


Gly Leu Phe His Asp Pro Ser Ile Gly Asn Pro Ile His Ile Thr Ile 
            260                 265                 270         


Val Arg Leu Val Leu Leu Glu Asp Glu Glu Glu Asp Leu Lys Ile Thr 
        275                 280                 285             


His His Ala Asp Asn Thr Leu Lys Ser Phe Cys Lys Trp Gln Lys Ser 
    290                 295                 300                 


Ile Asn Met Lys Gly Asp Ala His Pro Leu His His Asp Thr Ala Ile 
305                 310                 315                 320 


Leu Leu Thr Arg Lys Asp Leu Cys Ala Ala Met Asn Arg Pro Cys Glu 
                325                 330                 335     


Thr Leu Gly Leu Ser His Val Ala Gly Met Cys Gln Pro His Arg Ser 
            340                 345                 350         


Cys Ser Ile Asn Glu Asp Thr Gly Leu Pro Leu Ala Phe Thr Val Ala 
        355                 360                 365             


His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly Ser Gly Asn 
    370                 375                 380                 


Asp Cys Glu Pro Val Gly Lys Arg Pro Phe Ile Met Ser Pro Gln Leu 
385                 390                 395                 400 


Leu Tyr Asp Ala Ala Pro Leu Thr Trp Ser Arg Cys Ser Arg Gln Tyr 
                405                 410                 415     


Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu Asp Asp Pro 
            420                 425                 430         


Pro Ala Lys Asp Ile Ile Asp Phe Pro Ser Val Pro Pro Gly Val Leu 
        435                 440                 445             


Tyr Asp Val Ser His Gln Cys Arg Leu Gln Tyr Gly Ala Tyr Ser Ala 
    450                 455                 460                 


Phe Cys Glu Asp Met Asp Asn Val Cys His Thr Leu Trp Cys Ser Val 
465                 470                 475                 480 


Gly Thr Thr Cys His Ser Lys Leu Asp Ala Ala Val Asp Gly Thr Arg 
                485                 490                 495     


Cys Gly Glu Asn Lys Trp Cys Leu Ser Gly Glu Cys Val Pro Val Gly 
            500                 505                 510         


Phe Arg Pro Glu Ala Val Gly Ser Glu Asn Leu Tyr Phe Gln Ser Gly 
        515                 520                 525             


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys His His His His 
545                 550                 555                 560 


His His 
        


<210>  32
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse ADAMTS-7 prodomain (Mouse_Pro)

<400>  32

Leu Val Thr Glu Gly Arg Ala Gly Leu Asp Ile Val His Pro Val Arg 
1               5                   10                  15      


Val Asp Ala Gly Gly Ser Phe Leu Ser Tyr Glu Leu Trp Pro Arg Val 
            20                  25                  30          


Leu Arg Lys Arg Asp Val Ser Thr Thr Gln Ala Ser Ser Ala Phe Tyr 
        35                  40                  45              


Gln Leu Gln Tyr Gln Gly Arg Glu Leu Leu Phe Asn Leu Thr Thr Asn 
    50                  55                  60                  


Pro Tyr Leu Met Ala Pro Gly Phe Val Ser Glu Ile Arg Arg His Ser 
65                  70                  75                  80  


Thr Leu Gly His Ala His Ile Gln Thr Ser Val Pro Thr Cys His Leu 
                85                  90                  95      


Leu Gly Asp Val Gln Asp Pro Glu Leu Glu Gly Gly Phe Ala Ala Ile 
            100                 105                 110         


Ser Ala Cys Asp Gly Leu Arg Gly Val Phe Gln Leu Ser Asn Glu Asp 
        115                 120                 125             


Tyr Phe Ile Glu Pro Leu Asp Gly Val Ser Ala Gln Pro Gly His Ala 
    130                 135                 140                 


Gln Pro His Val Val Tyr Lys His Gln Gly Ser Arg Lys Gln Ala Gln 
145                 150                 155                 160 


Gln Gly Asp Ser Arg Pro Ser Gly Thr Cys Gly Met Gln Val Pro Pro 
                165                 170                 175     


Asp Leu Glu Gln Gln Arg Glu His Trp Glu Gln Gln Gln Gln Lys Arg 
            180                 185                 190         


Arg Gln Gln Arg 
        195     


<210>  33
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSP-1 candidate region

<400>  33

Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr 
1               5                   10                  15      


Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu Asn 
            20                  25                  30          


Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys 
        35                  40                  45  


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'loxP F for 3 primer PCR assay

<400>  34
tagaatagcg ggctctcgtg                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LacZ F for 3 primer PCR assay

<400>  35
tttccatatg gggattggtg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'loxP R for 3 primer PCR assay

<400>  36
ctcgggaatg gaatcttgac                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Sequence

<400>  37
ttacctgtgt cctagctcgt                                                   20


<210>  38
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM Site

<400>  38
tgggcctgtc tcatgtgtct ggcttgtgcc accctcagct cagctgtagc gtcagtgagg       60

atactggcat gccactggcc ttcactgtgg ctcaccagct aggacacagg taactcatct      120

tccctcacct ct                                                          132


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adamts7 in06F

<400>  39
ccttctgagg tcccagtgag                                                   20


<210>  40
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adamts7 ex07Rp

<400>  40
ctgcaggaat tcgatatcaa gcttatcgat acctgtgtcc tagctcgtgg                  50


<210>  41
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mut Adamts7 E373Q R

<400>  41
cctgtgtcct agctggtga                                                    19


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Noc41 region

<400>  42
caccctgtgt cctagctcct                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zfp446 region

<400>  43
gaacctgtgt cccagctctt                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ncoa2 region

<400>  44
tcacctgggt ccgagctggt                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Drosha region

<400>  45
ctacctgttt cctagcttgg                                                   20


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adamts7 ex05 F

<400>  46
cgatcatgaa catggtggct gg                                                22


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adamts7 ex08 R

<400>  47
tggacggtca tctaagcaca gg                                                22


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adamts7 in07 R

<400>  48
actccctcag gtttcgtgac                                                   20


