                         SEQUENCE LISTING

<110>  NEL, ANDRE E.
       XIA, TIAN
       LIU, QI
 
<120>  POLYMERIC NANOPARTICLES THAT TARGET LIVER SINUSOIDAL ENDOTHELIAL 
       CELLS TO INDUCE ANTIGEN-SPECIFIC IMMUNE TOLERANCE

<130>  UCLAP214WO

<140>  PCT/US2020/060036
<141>  2020-11-11

<150>  US 62/933,898
<151>  2019-11-11

<150>  US 62/706,002
<151>  2020-07-24

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic targeting peptide

<400>  1

Cys Gly Gly Lys Leu Gly Arg Lys Arg Tyr Leu Arg 
1               5                   10          


<210>  2
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic targeting peptide

<400>  2

Arg Lys Arg Gly Leu Lys 
1               5       


<210>  3
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic targeting peptide

<400>  3

Arg Leu Tyr Arg Lys Arg Gly Leu Lys 
1               5                   


<210>  4
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic targeting peptide

<400>  4

Cys Lys Asn Glu Lys Lys Asn Lys Ile Glu Arg Asn Asn Lys Leu Lys 
1               5                   10                  15      


Gln Pro Pro 
            


<210>  5
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  5

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg 
    


<210>  6
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  6

Lys Leu Thr Glu Trp Thr Ser Ser Asn Val Met Glu Glu Arg Lys Ile 
1               5                   10                  15      


<210>  7
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  7

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  8
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is citruline

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is citruline

<400>  8

Ala Xaa Gly Leu Thr Gly Xaa Pro Gly Asp Ala Lys 
1               5                   10          


<210>  9
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is citruline

<400>  9

His Gln Cys His Gln Glu Ser Thr Xaa Gly Arg Ser Arg Gly Arg Cys 
1               5                   10                  15      


Gly Arg Ser Gly Ser 
            20      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is citruline

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is citruline

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is citruline

<400>  10

Xaa Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr Xaa Ala Xaa Thr 
1               5                   10                  15      


<210>  11
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is citruline

<400>  11

Ser Ala Val Arg Ala Xaa Ser Ser Val Pro Gly Val Arg Lys 
1               5                   10                  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  12

Val Met Asn Ile Leu Leu Gln Tyr Val Val 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  13

Arg Met Met Glu Tyr Gly Thr Thr Met Val 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  14

Asn Leu Ala Gln Thr Asp Leu Ala Thr Val 
1               5                   10  


<210>  15
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  15

Gln Leu Ala Arg Gln Gln Val His Val 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  16

Ser Leu Ser Pro Leu Gln Ala Glu Leu 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  17

Ser Leu Ala Ala Gly Val Lys Leu Leu 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  18

Val Ile Val Met Leu Thr Pro Leu Val 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  19

Lys Leu Gln Val Phe Leu Ile Val Leu 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  20

Phe Leu Ile Val Leu Ser Val Ala Leu 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  21

Phe Leu Trp Ser Val Phe Met Leu Ile 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  22

Asn Leu Phe Leu Phe Leu Phe Ala Val 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  23

Phe Leu Phe Ala Val Gly Phe Tyr Leu 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  24

Tyr Leu Leu Leu Arg Val Leu Asn Ile 
1               5                   


<210>  25
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  25

Leu Asn Ile Asp Leu Leu Trp Ser 
1               5               


<210>  26
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  26

Val Leu Phe Gly Leu Gly Phe Ala Ile 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  27

Arg Leu Leu Cys Ala Leu Thr Ser Leu 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  28

Ala Leu Trp Met Arg Leu Leu Pro Leu 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  29

Leu Trp Met Arg Leu Leu Pro Leu Leu 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  30

Arg Leu Leu Pro Leu Leu Ala Leu Leu 
1               5                   


<210>  31
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  31

His Leu Cys Gly Ser His Leu Val Glu Ala 
1               5                   10  


<210>  32
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  32

His Leu Val Glu Ala Leu Tyr Leu Val 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  33

Ala Leu Tyr Leu Val Cys Gly Glu Arg 
1               5                   


<210>  34
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  34

Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
1               5                   10  


<210>  35
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  35

Leu Val Cys Gly Glu Arg Gly Phe Phe 
1               5                   


<210>  36
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  36

Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr 
1               5                   10  


<210>  37
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  37

Gly Glu Arg Gly Phe Phe Tyr Thr 
1               5               


<210>  38
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  38

Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  39

Phe Tyr Thr Pro Lys Thr Arg Arg Glu 
1               5                   


<210>  40
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  40

Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu 
1               5                   10      


<210>  41
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  41

Ser Leu Gln Pro Leu Ala Leu Glu Gly 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  42

Ala Leu Glu Gly Ser Leu Gln Lys Arg 
1               5                   


<210>  43
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  43

Ser Leu Gln Lys Arg Gly Ile Val Glu Gln 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  44

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile 
1               5                   10  


<210>  45
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  45

Ile Val Glu Gln Cys Cys Thr Ser Ile 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  46

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys 
1               5                   


<210>  47
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  47

His Ser Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe 
1               5                   10              


<210>  48
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  48

Asn Thr Trp Thr Thr Ser Gln Ser Ile Ala Phe Pro Ser Lys 
1               5                   10                  


<210>  49
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  49

Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser 
1               5                   10                  15      


Gln Gly Lys Gly Arg 
            20      


<210>  50
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  50

Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  51

Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  52

Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  53

Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  54

His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  55

Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
1               5                   10                  15  


<210>  56
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  56

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  57
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  57

Asp Glu Gly Gly Tyr Thr Cys Phe Phe Arg Asp His Ser Tyr Gln 
1               5                   10                  15  


<210>  58
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  58

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg 
    


<210>  59
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  59

Glu Lys Pro Lys Val Glu Ala Tyr Lys Ala Ala Ala Ala Pro Ala 
1               5                   10                  15  


<210>  60
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  60

Ser Leu Leu Leu Glu Leu Glu Glu Val 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  61

Leu Met Trp Ala Lys Ile Gly Pro Val 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  62

Val Leu Phe Ser Ser Asp Phe Arg Ile 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  63

Ser Leu Ser Arg Phe Ser Trp Gly Ala 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  64

Lys Val Glu Asp Pro Phe Tyr Trp Val 
1               5                   


<210>  65
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  65

Arg Thr Phe Asp Pro His Phe Leu Arg Val 
1               5                   10  


<210>  66
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  66

Phe Leu Arg Val Pro Cys Trp Lys Ile 
1               5                   


<210>  67
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  67

Lys Ile Thr Leu Phe Val Ile Val Pro Val 
1               5                   10  


<210>  68
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  68

Val Leu Gly Pro Leu Val Ala Leu Ile 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  69

Thr Leu Phe Val Ile Val Pro Val Leu 
1               5                   


<210>  70
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  70

Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu 
1               5                   10  


<210>  71
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  71

Phe Leu Tyr Gly Ala Leu Leu Leu Ala 
1               5                   


<210>  72
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  72

Leu Ala Leu Phe Leu Leu Ala Ala His Ala Ser Ala Arg Gln Gln 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  73

Leu Arg Asn Leu Pro Gln Gln Cys Gly Leu Arg Ala Pro Gln Arg 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  74

Met Ala Lys Leu Thr Ile Leu Val Ala Leu Ala Leu Phe Leu Leu 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  75

Ser Tyr Gly Arg Asp Pro Tyr Ser Pro Ser Gln Asp Pro Tyr Ser 
1               5                   10                  15  


<210>  76
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope

<400>  76

His Ala Ser Ala Arg Gln Gln Trp Glu Leu 
1               5                   10  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide epitope


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is citruline

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is citruline

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is citruline

<400>  77

Xaa Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr Xaa Ala Xaa 
1               5                   10                  15  


