                         SEQUENCE LISTING

<110>  CRISPR Therapeutics AG
 
<120>  THERAPY FOR T CELL AND B CELL MALIGNANCIES USING GENETICALLY 
       ENGINEERED T CELLS TARGETING CD70

<130>  095136-0188-010WO1

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/934,945
<151>  2019-11-13

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  2
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  2
gcuuuggucc cauuggucgc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  3
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
gcuuuggucc cauuggucgc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  4
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  4
gcuuuggucc cauuggucgc                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
gcuuuggucc cauuggucgc                                                   20


<210>  6
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  6
agagcaacag ugcuguggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  7
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
agagcaacag ugcuguggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  8
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  8
agagcaacag ugcuguggcc                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
agagcaacag ugcuguggcc                                                   20


<210>  10
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  10
gcuacucucu cuuucuggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  11
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gcuacucucu cuuucuggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  12
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  12
gcuacucucu cuuucuggcc                                                   20


<210>  13
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
gcuacucucu cuuucuggcc                                                   20


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
gctttggtcc cattggtcgc ggg                                               23


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
gctttggtcc cattggtcgc                                                   20


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
agagcaacag tgctgtggcc tgg                                               23


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
agagcaacag tgctgtggcc                                                   20


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
gctactctct ctttctggcc tgg                                               23


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gctactctct ctttctggcc                                                   20


<210>  20
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  20
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  21
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  21
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  22
<211>  114
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (18)..(30)
<223>  may be absent

<220>
<221>  misc_feature
<222>  (109)..(114)
<223>  may be absent

<400>  22
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau       60

aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uuuu            114


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
aagagcaaca aatctgact                                                    19


<210>  24
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
aagagcaaca gtgctgtgcc tggagcaaca aatctgact                              39


<210>  25
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
aagagcaaca gtgctggagc aacaaatctg act                                    33


<210>  26
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
aagagcaaca gtgcctggag caacaaatct gact                                   34


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
aagagcaaca gtgctgact                                                    19


<210>  28
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
aagagcaaca gtgctgtggg cctggagcaa caaatctgac t                           41


<210>  29
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
aagagcaaca gtgctggcct ggagcaacaa atctgact                               38


<210>  30
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
aagagcaaca gtgctgtgtg cctggagcaa caaatctgac t                           41


<210>  31
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
cgtggcctta gctgtgctcg cgctactctc tctttctgcc tggaggctat ccagcgtgag       60

tctctcctac cctcccgct                                                    79


<210>  32
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
cgtggcctta gctgtgctcg cgctactctc tctttcgcct ggaggctatc cagcgtgagt       60

ctctcctacc ctcccgct                                                     78


<210>  33
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
cgtggcctta gctgtgctcg cgctactctc tctttctgga ggctatccag cgtgagtctc       60

tcctaccctc ccgct                                                        75


<210>  34
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
cgtggcctta gctgtgctcg cgctactctc tctttctgga tagcctggag gctatccagc       60

gtgagtctct cctaccctcc cgct                                              84


<210>  35
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
cgtggcctta gctgtgctcg cgctatccag cgtgagtctc tcctaccctc ccgct            55


<210>  36
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
cgtggcctta gctgtgctcg cgctactctc tctttctgtg gcctggaggc tatccagcgt       60

gagtctctcc taccctcccg ct                                                82


<210>  37
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
cacaccacga ggcagatcac caagcccgcg caatgggacc aaagcagccc gcaggacg         58


<210>  38
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
cacaccacga ggcagatcac caagcccgcg aaccaatggg accaaagcag cccgcaggac       60

g                                                                       61


<210>  39
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
cacaccacga ggcagatcac caatgggacc aaagcagccc gcaggacg                    48


<210>  40
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
cacaccacga ggcagatcac caagcccgcg ccaatgggac caaagcagcc cgcaggacg        59


<210>  41
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
cacaccacga ggcagatcac caagcccgca ccaatgggac caaagcagcc cgcaggacg        59


<210>  42
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
cacaccacga ggcagatcac caagcccgca ggacg                                  35


<210>  43
<211>  4688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcac gcgtgagatg taaggagctg ctgtgacttg ctcaaggcct      180

tatatcgagt aaacggtagt gctggggctt agacgcaggt gttctgattt atagttcaaa      240

acctctatca atgagagagc aatctcctgg taatgtgata gatttcccaa cttaatgcca      300

acataccata aacctcccat tctgctaatg cccagcctaa gttggggaga ccactccaga      360

ttccaagatg tacagtttgc tttgctgggc ctttttccca tgcctgcctt tactctgcca      420

gagttatatt gctggggttt tgaagaagat cctattaaat aaaagaataa gcagtattat      480

taagtagccc tgcatttcag gtttccttga gtggcaggcc aggcctggcc gtgaacgttc      540

actgaaatca tggcctcttg gccaagattg atagcttgtg cctgtccctg agtcccagtc      600

catcacgagc agctggtttc taagatgcta tttcccgtat aaagcatgag accgtgactt      660

gccagcccca cagagccccg cccttgtcca tcactggcat ctggactcca gcctgggttg      720

gggcaaagag ggaaatgaga tcatgtccta accctgatcc tcttgtccca cagatatcca      780

gaaccctgac cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg      840

cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta      900

tatcacagac aaaactgtgc tagacatgag gtctatggac ttcaggctcc ggtgcccgtc      960

agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt     1020

gaaccggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc     1080

tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg     1140

ttctttttcg caacgggttt gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg     1200

ggcctggcct ctttacgggt tatggccctt gcgtgccttg aattacttcc actggctgca     1260

gtacgtgatt cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg     1320

cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg     1380

ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc     1440

catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa     1500

tgcgggccaa gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc     1560

ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat     1620

cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg     1680

tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag     1740

atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga     1800

gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc     1860

atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg     1920

gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga     1980

gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc     2040

cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt     2100

tcttccattt caggtgtcgt gaccaccatg gcgcttccgg tgacagcact gctcctcccc     2160

ttggcgctgt tgctccacgc agcaaggccg caggtccagt tggtgcaaag cggggcggag     2220

gtgaaaaaac ccggcgcttc cgtgaaggtg tcctgtaagg cgtccggtta tacgttcacg     2280

aactacggga tgaattgggt tcgccaagcg ccggggcagg gactgaaatg gatggggtgg     2340

ataaatacct acaccggcga acctacatac gccgacgctt ttaaagggcg agtcactatg     2400

acgcgcgata ccagcatatc caccgcatac atggagctgt cccgactccg gtcagacgac     2460

acggctgtct actattgtgc tcgggactat ggcgattatg gcatggacta ctggggtcag     2520

ggtacgactg taacagttag tagtggtgga ggcggcagtg gcgggggggg aagcggagga     2580

gggggttctg gtgacatagt tatgacccaa tccccagata gtttggcggt ttctctgggc     2640

gagagggcaa cgattaattg tcgcgcatca aagagcgttt caacgagcgg atattctttt     2700

atgcattggt accagcaaaa acccggacaa ccgccgaagc tgctgatcta cttggcttca     2760

aatcttgagt ctggggtgcc ggaccgattt tctggtagtg gaagcggaac tgactttacg     2820

ctcacgatca gttcactgca ggctgaggat gtagcggtct attattgcca gcacagtaga     2880

gaagtcccct ggaccttcgg tcaaggcacg aaagtagaaa ttaaaagtgc tgctgccttt     2940

gtcccggtat ttctcccagc caaaccgacc acgactcccg ccccgcgccc tccgacaccc     3000

gctcccacca tcgcctctca acctcttagt cttcgccccg aggcatgccg acccgccgcc     3060

gggggtgctg ttcatacgag gggcttggac ttcgcttgtg atatttacat ttgggctccg     3120

ttggcgggta cgtgcggcgt ccttttgttg tcactcgtta ttactttgta ttgtaatcac     3180

aggaatcgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     3240

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     3300

ggaggatgtg aactgcgagt gaagttttcc cgaagcgcag acgctccggc atatcagcaa     3360

ggacagaatc agctgtataa cgaactgaat ttgggacgcc gcgaggagta tgacgtgctt     3420

gataaacgcc gggggagaga cccggaaatg gggggtaaac cccgaagaaa gaatccccaa     3480

gaaggactct acaatgaact ccagaaggat aagatggcgg aggcctactc agaaataggt     3540

atgaagggcg aacgacgacg gggaaaaggt cacgatggcc tctaccaagg gttgagtacg     3600

gcaaccaaag atacgtacga tgcactgcat atgcaggccc tgcctcccag ataataataa     3660

aatcgctatc catcgaagat ggatgtgtgt tggttttttg tgtgtggagc aacaaatctg     3720

actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc ttcttcccca     3780

gcccaggtaa gggcagcttt ggtgccttcg caggctgttt ccttgcttca ggaatggcca     3840

ggttctgccc agagctctgg tcaatgatgt ctaaaactcc tctgattggt ggtctcggcc     3900

ttatccattg ccaccaaaac cctcttttta ctaagaaaca gtgagccttg ttctggcagt     3960

ccagagaatg acacgggaaa aaagcagatg aagagaaggt ggcaggagag ggcacgtggc     4020

ccagcctcag tctctccaac tgagttcctg cctgcctgcc tttgctcaga ctgtttgccc     4080

cttactgctc ttctaggcct cattctaagc cccttctcca agttgcctct ccttatttct     4140

ccctgtctgc caaaaaatct ttcccagctc actaagtcag tctcacgcag tcactcatta     4200

acccaccaat cactgattgt gccggcacat gaatgcacca ggtgttgaag tggaggaatt     4260

aaaaagtcag atgaggggtg tgcccagagg aagcaccatt ctagttgggg gagcccatct     4320

gtcagctggg aaaagtccaa ataacttcag attggaatgt gttttaactc agggttgaga     4380

aaacagctac cttcaggaca aaagtcaggg aagggctctc tgaagaaatg ctacttgaag     4440

ataccagccc taccaagggc agggagagga ccctatagag gcctgggaca ggagctcaat     4500

gagaaaggta accacgtgcg gaccgaggct gcagcgtcgt cctccctagg aacccctagt     4560

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4620

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg     4680

cctgcagg                                                              4688


<210>  44
<211>  4364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca ggctccggtg cccgtcagtg ggcagagcgc acatcgccca      840

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc      900

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg      960

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     1020

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     1080

gcccttgcgt gccttgaatt acttccactg gctgcagtac gtgattcttg atcccgagct     1140

tcgggttgga agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg     1200

tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct     1260

tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc     1320

tgcgacgctt tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg     1380

tatttcggtt tttggggccg cgggcggcga cggggcccgt gcgtcccagc gcacatgttc     1440

ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg     1500

ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag     1560

gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc     1620

agggagctca aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca     1680

aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc     1740

gccgtccagg cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg     1800

ggaggggttt tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc     1860

agcttggcac ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt     1920

cattctcaag cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcgtgacc     1980

accatggcgc ttccggtgac agcactgctc ctccccttgg cgctgttgct ccacgcagca     2040

aggccgcagg tccagttggt gcaaagcggg gcggaggtga aaaaacccgg cgcttccgtg     2100

aaggtgtcct gtaaggcgtc cggttatacg ttcacgaact acgggatgaa ttgggttcgc     2160

caagcgccgg ggcagggact gaaatggatg gggtggataa atacctacac cggcgaacct     2220

acatacgccg acgcttttaa agggcgagtc actatgacgc gcgataccag catatccacc     2280

gcatacatgg agctgtcccg actccggtca gacgacacgg ctgtctacta ttgtgctcgg     2340

gactatggcg attatggcat ggactactgg ggtcagggta cgactgtaac agttagtagt     2400

ggtggaggcg gcagtggcgg ggggggaagc ggaggagggg gttctggtga catagttatg     2460

acccaatccc cagatagttt ggcggtttct ctgggcgaga gggcaacgat taattgtcgc     2520

gcatcaaaga gcgtttcaac gagcggatat tcttttatgc attggtacca gcaaaaaccc     2580

ggacaaccgc cgaagctgct gatctacttg gcttcaaatc ttgagtctgg ggtgccggac     2640

cgattttctg gtagtggaag cggaactgac tttacgctca cgatcagttc actgcaggct     2700

gaggatgtag cggtctatta ttgccagcac agtagagaag tcccctggac cttcggtcaa     2760

ggcacgaaag tagaaattaa aagtgctgct gcctttgtcc cggtatttct cccagccaaa     2820

ccgaccacga ctcccgcccc gcgccctccg acacccgctc ccaccatcgc ctctcaacct     2880

cttagtcttc gccccgaggc atgccgaccc gccgccgggg gtgctgttca tacgaggggc     2940

ttggacttcg cttgtgatat ttacatttgg gctccgttgg cgggtacgtg cggcgtcctt     3000

ttgttgtcac tcgttattac tttgtattgt aatcacagga atcgcaaacg gggcagaaag     3060

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     3120

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gcgagtgaag     3180

ttttcccgaa gcgcagacgc tccggcatat cagcaaggac agaatcagct gtataacgaa     3240

ctgaatttgg gacgccgcga ggagtatgac gtgcttgata aacgccgggg gagagacccg     3300

gaaatggggg gtaaaccccg aagaaagaat ccccaagaag gactctacaa tgaactccag     3360

aaggataaga tggcggaggc ctactcagaa ataggtatga agggcgaacg acgacgggga     3420

aaaggtcacg atggcctcta ccaagggttg agtacggcaa ccaaagatac gtacgatgca     3480

ctgcatatgc aggccctgcc tcccagataa taataaaatc gctatccatc gaagatggat     3540

gtgtgttggt tttttgtgtg tggagcaaca aatctgactt tgcatgtgca aacgccttca     3600

acaacagcat tattccagaa gacaccttct tccccagccc aggtaagggc agctttggtg     3660

ccttcgcagg ctgtttcctt gcttcaggaa tggccaggtt ctgcccagag ctctggtcaa     3720

tgatgtctaa aactcctctg attggtggtc tcggccttat ccattgccac caaaaccctc     3780

tttttactaa gaaacagtga gccttgttct ggcagtccag agaatgacac gggaaaaaag     3840

cagatgaaga gaaggtggca ggagagggca cgtggcccag cctcagtctc tccaactgag     3900

ttcctgcctg cctgcctttg ctcagactgt ttgcccctta ctgctcttct aggcctcatt     3960

ctaagcccct tctccaagtt gcctctcctt atttctccct gtctgccaaa aaatctttcc     4020

cagctcacta agtcagtctc acgcagtcac tcattaaccc accaatcact gattgtgccg     4080

gcacatgaat gcaccaggtg ttgaagtgga ggaattaaaa agtcagatga ggggtgtgcc     4140

cagaggaagc accattctag ttgggggagc ccatctgtca gctgggaaaa gtccaaataa     4200

cttcagattg gaatgtgttt taactcaggg ttgagaaaac agctaccttc aggacaaaag     4260

tcagggaagg gctctctgaa gaaatgctac ttgaagatac cagccctacc aagggcaggg     4320

agaggaccct atagaggcct gggacaggag ctcaatgaga aagg                      4364


<210>  45
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
atggcgcttc cggtgacagc actgctcctc cccttggcgc tgttgctcca cgcagcaagg       60

ccgcaggtcc agttggtgca aagcggggcg gaggtgaaaa aacccggcgc ttccgtgaag      120

gtgtcctgta aggcgtccgg ttatacgttc acgaactacg ggatgaattg ggttcgccaa      180

gcgccggggc agggactgaa atggatgggg tggataaata cctacaccgg cgaacctaca      240

tacgccgacg cttttaaagg gcgagtcact atgacgcgcg ataccagcat atccaccgca      300

tacatggagc tgtcccgact ccggtcagac gacacggctg tctactattg tgctcgggac      360

tatggcgatt atggcatgga ctactggggt cagggtacga ctgtaacagt tagtagtggt      420

ggaggcggca gtggcggggg gggaagcgga ggagggggtt ctggtgacat agttatgacc      480

caatccccag atagtttggc ggtttctctg ggcgagaggg caacgattaa ttgtcgcgca      540

tcaaagagcg tttcaacgag cggatattct tttatgcatt ggtaccagca aaaacccgga      600

caaccgccga agctgctgat ctacttggct tcaaatcttg agtctggggt gccggaccga      660

ttttctggta gtggaagcgg aactgacttt acgctcacga tcagttcact gcaggctgag      720

gatgtagcgg tctattattg ccagcacagt agagaagtcc cctggacctt cggtcaaggc      780

acgaaagtag aaattaaaag tgctgctgcc tttgtcccgg tatttctccc agccaaaccg      840

accacgactc ccgccccgcg ccctccgaca cccgctccca ccatcgcctc tcaacctctt      900

agtcttcgcc ccgaggcatg ccgacccgcc gccgggggtg ctgttcatac gaggggcttg      960

gacttcgctt gtgatattta catttgggct ccgttggcgg gtacgtgcgg cgtccttttg     1020

ttgtcactcg ttattacttt gtattgtaat cacaggaatc gcaaacgggg cagaaagaaa     1080

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1140

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg agtgaagttt     1200

tcccgaagcg cagacgctcc ggcatatcag caaggacaga atcagctgta taacgaactg     1260

aatttgggac gccgcgagga gtatgacgtg cttgataaac gccgggggag agacccggaa     1320

atggggggta aaccccgaag aaagaatccc caagaaggac tctacaatga actccagaag     1380

gataagatgg cggaggccta ctcagaaata ggtatgaagg gcgaacgacg acggggaaaa     1440

ggtcacgatg gcctctacca agggttgagt acggcaacca aagatacgta cgatgcactg     1500

catatgcagg ccctgcctcc cagataa                                         1527


<210>  46
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Asp Ala Phe Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile 
                165                 170                 175     


Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu 
225                 230                 235                 240 


Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg Glu Val Pro Trp Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ala Ala Ala Phe Val 
            260                 265                 270         


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            340                 345                 350         


Asn Arg Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        355                 360                 365             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    370                 375                 380                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  47
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
caggtccagt tggtgcaaag cggggcggag gtgaaaaaac ccggcgcttc cgtgaaggtg       60

tcctgtaagg cgtccggtta tacgttcacg aactacggga tgaattgggt tcgccaagcg      120

ccggggcagg gactgaaatg gatggggtgg ataaatacct acaccggcga acctacatac      180

gccgacgctt ttaaagggcg agtcactatg acgcgcgata ccagcatatc caccgcatac      240

atggagctgt cccgactccg gtcagacgac acggctgtct actattgtgc tcgggactat      300

ggcgattatg gcatggacta ctggggtcag ggtacgactg taacagttag tagtggtgga      360

ggcggcagtg gcgggggggg aagcggagga gggggttctg gtgacatagt tatgacccaa      420

tccccagata gtttggcggt ttctctgggc gagagggcaa cgattaattg tcgcgcatca      480

aagagcgttt caacgagcgg atattctttt atgcattggt accagcaaaa acccggacaa      540

ccgccgaagc tgctgatcta cttggcttca aatcttgagt ctggggtgcc ggaccgattt      600

tctggtagtg gaagcggaac tgactttacg ctcacgatca gttcactgca ggctgaggat      660

gtagcggtct attattgcca gcacagtaga gaagtcccct ggaccttcgg tcaaggcacg      720

aaagtagaaa ttaaa                                                       735


<210>  48
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Ala Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser 
    130                 135                 140                 


Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser 
145                 150                 155                 160 


Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe Met His Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln His Ser Arg Glu Val Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  49
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Ala Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  50
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  51
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
ggggsggggs ggggsg                                                       16


<210>  52
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  53
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  54
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  55
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  56
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  57
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  58
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
tcaaagcgga gtaggttgtt gcattccgat tacatgaata tgactcctcg ccggcctggg       60

ccgacaagaa aacattacca accctatgcc cccccacgag acttcgctgc gtacaggtcc      120


<210>  59
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  60
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
cgagtgaagt tttcccgaag cgcagacgct ccggcatatc agcaaggaca gaatcagctg       60

tataacgaac tgaatttggg acgccgcgag gagtatgacg tgcttgataa acgccggggg      120

agagacccgg aaatgggggg taaaccccga agaaagaatc cccaagaagg actctacaat      180

gaactccaga aggataagat ggcggaggcc tactcagaaa taggtatgaa gggcgaacga      240

cgacggggaa aaggtcacga tggcctctac caagggttga gtacggcaac caaagatacg      300

tacgatgcac tgcatatgca ggccctgcct cccaga                                336


<210>  61
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  62
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
gagatgtaag gagctgctgt gacttgctca aggccttata tcgagtaaac ggtagtgctg       60

gggcttagac gcaggtgttc tgatttatag ttcaaaacct ctatcaatga gagagcaatc      120

tcctggtaat gtgatagatt tcccaactta atgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg ccgtgtacca      660

gctgagagac tctaaatcca gtgacaagtc tgtctgccta ttcaccgatt ttgattctca      720

aacaaatgtg tcacaaagta aggattctga tgtgtatatc acagacaaaa ctgtgctaga      780

catgaggtct atggacttca                                                  800


<210>  63
<211>  1178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccactg gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg      360

agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc      420

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt      480

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc      540

aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg      600

cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag      660

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg      720

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag      780

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga      840

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt      900

cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt      960

agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     1020

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     1080

tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     1140

tggttcaaag tttttttctt ccatttcagg tgtcgtga                             1178


<210>  64
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
aataaaatcg ctatccatcg aagatggatg tgtgttggtt ttttgtgtg                   49


<210>  65
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa       60

gacaccttct tccccagccc aggtaagggc agctttggtg ccttcgcagg ctgtttcctt      120

gcttcaggaa tggccaggtt ctgcccagag ctctggtcaa tgatgtctaa aactcctctg      180

attggtggtc tcggccttat ccattgccac caaaaccctc tttttactaa gaaacagtga      240

gccttgttct ggcagtccag agaatgacac gggaaaaaag cagatgaaga gaaggtggca      300

ggagagggca cgtggcccag cctcagtctc tccaactgag ttcctgcctg cctgcctttg      360

ctcagactgt ttgcccctta ctgctcttct aggcctcatt ctaagcccct tctccaagtt      420

gcctctcctt atttctccct gtctgccaaa aaatctttcc cagctcacta agtcagtctc      480

acgcagtcac tcattaaccc accaatcact gattgtgccg gcacatgaat gcaccaggtg      540

ttgaagtgga ggaattaaaa agtcagatga ggggtgtgcc cagaggaagc accattctag      600

ttgggggagc ccatctgtca gctgggaaaa gtccaaataa cttcagattg gaatgtgttt      660

taactcaggg ttgagaaaac agctaccttc aggacaaaag tcagggaagg gctctctgaa      720

gaaatgctac ttgaagatac cagccctacc aagggcaggg agaggaccct atagaggcct      780

gggacaggag ctcaatgaga aagg                                             804


<210>  66
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<220>
<221>  misc_feature
<222>  (97)..(100)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  66
gcccgcagga cgcacccaua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  67
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
gcccgcagga cgcacccaua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  68
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with 2'-O-methyl phosphorothioate

<400>  68
gcccgcagga cgcacccaua                                                   20


<210>  69
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
gcccgcagga cgcacccaua                                                   20


