﻿                         序列表

<110>  深圳宾德生物技术有限公司

<120>  一种靶向FGFR4和DR5的嵌合抗原受体T细胞及其制备方法和应用

<150>  CN201911120424.0
<151>  2019-11-15

<160>  11

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<400>  1
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Glu Ile Ser Asn Gly Gly Arg Tyr Ile Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  
Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Gly Glu Lys Thr Ser Gly Tyr Val Trp Phe Ala Tyr Trp 
            100                 105                 110         
Gly Glu Gly Thr Leu Val Thr Val 
        115                 120 

<210>  2
<211>  106
<212>  PRT
<213>  Artificial Sequence

<400>  2
Asp Ile Gln Met Thr Gln Thr Pro Ala Ser Leu Ser Ala Ser Val Glu 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Arg Ser Pro Gln Leu Leu Leu 
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His Phe Ser Gly Thr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile 
            100                 105     

<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<400>  3
Glu Val Met Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Leu Cys 
                85                  90                  95      
Val Arg Ser Ser Ser Gly Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ile Val Thr Val 
        115     

<210>  4
<211>  111
<212>  PRT
<213>  Artificial Sequence

<400>  4
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asn Leu Leu Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile 
            100                 105                 110     

<210>  5
<211>  246
<212>  PRT
<213>  Artificial Sequence

<400>  5
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asn Leu Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Thr Cys 
145                 150                 155                 160 
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     
Gly Glu Ile Asn Pro Asp Ser Ser Arg Ile Asn Tyr Met Pro Ser Leu 
            180                 185                 190         
Lys Glu Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
        195                 200                 205             
Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
    210                 215                 220                 
Ala Arg Gly Gly Thr Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 
Ser Val Thr Val Ser Ser 
                245     

<210>  6
<211>  241
<212>  PRT
<213>  Artificial Sequence

<400>  6
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Glu Ile Ser Asn Gly Gly Arg Tyr Ile Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  
Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Gly Glu Lys Thr Ser Gly Tyr Val Trp Phe Ala Tyr Trp 
            100                 105                 110         
Gly Glu Gly Thr Leu Val Thr Val Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro Ala 
    130                 135                 140                 
Ser Leu Ser Ala Ser Val Glu Glu Thr Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 
Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
                165                 170                 175     
Arg Ser Pro Gln Leu Leu Leu Tyr Asn Ala Lys Thr Leu Ala Glu Gly 
            180                 185                 190         
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu 
        195                 200                 205             
Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ile Tyr Tyr Cys Gln 
    210                 215                 220                 
His Phe Ser Gly Thr Pro Tyr Thr Phe Gly Glu Gly Thr Lys Leu Glu 
225                 230                 235                 240 
Ile 
    

<210>  7
<211>  242
<212>  PRT
<213>  Artificial Sequence

<400>  7
Glu Val Met Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Leu Cys 
                85                  90                  95      
Val Arg Ser Ser Ser Gly Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ile Val Thr Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val 
    130                 135                 140                 
Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
145                 150                 155                 160 
Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     
Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
            180                 185                 190         
Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             
Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
    210                 215                 220                 
Cys Lys Gln Ser Tyr Asn Leu Leu Thr Phe Gly Glu Gly Thr Lys Leu 
225                 230                 235                 240 
Glu Ile 
        

<210>  8
<211>  464
<212>  PRT
<213>  Artificial Sequence

<400>  8
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Glu Ile Ser Asn Gly Gly Arg Tyr Ile Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  
Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Val Arg Gly Gly Glu Lys Thr Ser Gly Tyr Val Trp Phe Ala Tyr Trp 
            100                 105                 110         
Gly Glu Gly Thr Leu Val Thr Val Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro Ala 
    130                 135                 140                 
Ser Leu Ser Ala Ser Val Glu Glu Thr Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 
Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
                165                 170                 175     
Arg Ser Pro Gln Leu Leu Leu Tyr Asn Ala Lys Thr Leu Ala Glu Gly 
            180                 185                 190         
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu 
        195                 200                 205             
Lys Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ile Tyr Tyr Cys Gln 
    210                 215                 220                 
His Phe Ser Gly Thr Pro Tyr Thr Phe Gly Glu Gly Thr Lys Leu Glu 
225                 230                 235                 240 
Ile Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     
Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         
Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    290                 295                 300                 
Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
305                 310                 315                 320 
Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                325                 330                 335     
Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            340                 345                 350         
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
        355                 360                 365             
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                405                 410                 415     
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            420                 425                 430         
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        435                 440                 445             
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460                 

<210>  9
<211>  465
<212>  PRT
<213>  Artificial Sequence

<400>  9
Glu Val Met Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Leu Cys 
                85                  90                  95      
Val Arg Ser Ser Ser Gly Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ile Val Thr Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val 
    130                 135                 140                 
Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
145                 150                 155                 160 
Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     
Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
            180                 185                 190         
Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             
Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
    210                 215                 220                 
Cys Lys Gln Ser Tyr Asn Leu Leu Thr Phe Gly Glu Gly Thr Lys Leu 
225                 230                 235                 240 
Glu Ile Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 
Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        355                 360                 365             
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 
Arg 
465 

<210>  10
<211>  469
<212>  PRT
<213>  Artificial Sequence

<400>  10
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asn Leu Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    130                 135                 140                 
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Thr Cys 
145                 150                 155                 160 
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
                165                 170                 175     
Gly Glu Ile Asn Pro Asp Ser Ser Arg Ile Asn Tyr Met Pro Ser Leu 
            180                 185                 190         
Lys Glu Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
        195                 200                 205             
Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
    210                 215                 220                 
Ala Arg Gly Gly Thr Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 
Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     
Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         
Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             
Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
    290                 295                 300                 
Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
305                 310                 315                 320 
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
                325                 330                 335     
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
            340                 345                 350         
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        355                 360                 365             
Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    370                 375                 380                 
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
385                 390                 395                 400 
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 
Ala Leu Pro Pro Arg 
465                 

<210>  11
<211>  21
<212>  PRT
<213>  Artificial Sequence

<400>  11
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro 
            20      

