                         SEQUENCE LISTING

<110>  Qi, Zhankai
 
<120>  Use of snake NGF and preproNGF for the treatment of Alzheimer's 
       Disease

<130>  PCT-NGF-AD

<140>  PCT/001
<141>  2020-09-09

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  241
<212>  PRT
<213>  噬鱼蝮（Agkistrodon piscivorus）

<400>  1

Met Ser Met Leu Cys Tyr Thr Leu Ile Ile Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Trp Ala Ala Pro Lys Ser Glu Asp Asn Val Pro Leu Gly Ser Pro Ala 
            20                  25                  30          


Thr Ser Asp Leu Ser Asp Thr Ser Cys Ala Lys Thr His Glu Ala Leu 
        35                  40                  45              


Lys Thr Ser Arg Asn Thr Asp Gln His Tyr Pro Ala Pro Lys Lys Ala 
    50                  55                  60                  


Glu Asp Gln Glu Phe Gly Ser Ala Ala Asn Ile Ile Val Asp Pro Lys 
65                  70                  75                  80  


Leu Phe Gln Lys Arg Arg Phe Gln Ser Pro Arg Val Leu Phe Ser Thr 
                85                  90                  95      


Gln Pro Pro Pro Leu Ser Arg Asp Glu Gln Asn Val Asp Asn Ala Asn 
            100                 105                 110         


Ser Leu Asn Arg Asn Ile Arg Ala Lys Arg Glu Asp His Pro Val His 
        115                 120                 125             


Asn Arg Gly Glu Tyr Ser Val Cys Asp Ser Val Asn Val Trp Val Ala 
    130                 135                 140                 


Asn Lys Thr Thr Ala Thr Asp Ile Arg Gly Asn Val Val Thr Val Met 
145                 150                 155                 160 


Val Asp Val Asn Ile Asn Asn Asn Val Tyr Lys Gln Tyr Phe Phe Glu 
                165                 170                 175     


Thr Lys Cys Arg Asn Pro Asn Pro Val Pro Thr Gly Cys Arg Gly Ile 
            180                 185                 190         


Asp Ala Arg His Trp Asn Ser Tyr Cys Thr Thr Thr Asn Thr Phe Val 
        195                 200                 205             


Lys Ala Leu Thr Met Glu Gly Asn Gln Ala Ser Trp Arg Phe Ile Arg 
    210                 215                 220                 


Ile Asp Ser Ala Cys Val Cys Val Ile Ser Arg Lys Asn Glu Asn Phe 
225                 230                 235                 240 


Gly 
    


<210>  2
<211>  110
<212>  PRT
<213>  噬鱼蝮（Agkistrodon piscivorus）

<400>  2

His Asn Arg Gly Glu Tyr Ser Val Cys Asp Ser Val Asn Val Trp Val 
1               5                   10                  15      


Ala Asn Lys Thr Thr Ala Thr Asp Ile Arg Gly Asn Val Val Thr Val 
            20                  25                  30          


Met Val Asp Val Asn Ile Asn Asn Asn Val Tyr Lys Gln Tyr Phe Phe 
        35                  40                  45              


Glu Thr Lys Cys Arg Asn Pro Asn Pro Val Pro Thr Gly Cys Arg Gly 
    50                  55                  60                  


Ile Asp Ala Arg His Trp Asn Ser Tyr Cys Thr Thr Thr Asn Thr Phe 
65                  70                  75                  80  


Val Lys Ala Leu Thr Met Glu Gly Asn Gln Ala Ser Trp Arg Phe Ile 
                85                  90                  95      


Arg Ile Asp Ser Ala Cys Val Cys Val Ile Ser Arg Lys Asn 
            100                 105                 110 


<210>  3
<211>  221
<212>  PRT
<213>  噬鱼蝮（Agkistrodon piscivorus）

<400>  3

Ser Cys Met Lys Ala Ala Pro Met Lys Glu Val Ser Ile Arg Gly Gln 
1               5                   10                  15      


Gly Ser Leu Ala Tyr Pro Gly Leu Arg Thr Gln Gly Asn Leu Glu Thr 
            20                  25                  30          


Leu Ser Gly Pro Asn Asp Ala Thr Arg Gly Leu Thr Ser Leu Ala Asp 
        35                  40                  45              


Thr Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Gln Gln Ala Ile 
    50                  55                  60                  


Gln Pro Ser Lys Glu Asn Lys Asp Ala Asp Leu Tyr Ser Ser Arg Val 
65                  70                  75                  80  


Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 
                85                  90                  95      


Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 
            100                 105                 110         


Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 
        115                 120                 125             


Ser Thr Ser Glu Trp Val Thr Ala Ala Glu Lys Lys Thr Ala Val Asp 
    130                 135                 140                 


Met Ser Gly Ala Thr Val Thr Val Leu Glu Lys Val Pro Val Pro Lys 
145                 150                 155                 160 


Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Ser Thr Lys Gly 
                165                 170                 175     


Tyr Ala Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg Tyr Trp Asn Ser 
            180                 185                 190         


Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Asn 
        195                 200                 205             


Lys Lys Arg Val Gly Trp Arg Phe Ile Arg Ile Asp Thr 
    210                 215                 220     


<210>  4
<211>  103
<212>  PRT
<213>  噬鱼蝮（Agkistrodon piscivorus）

<400>  4

Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Thr Ser Glu Trp Val 
1               5                   10                  15      


Thr Ala Ala Glu Lys Lys Thr Ala Val Asp Met Ser Gly Ala Thr Val 
            20                  25                  30          


Thr Val Leu Glu Lys Val Pro Val Pro Lys Gly Gln Leu Lys Gln Tyr 
        35                  40                  45              


Phe Tyr Glu Thr Lys Cys Ser Ala Lys Gly Tyr Ala Lys Glu Gly Cys 
    50                  55                  60                  


Arg Gly Ile Asp Lys Arg Tyr Trp Asn Ser Gln Cys Arg Thr Thr Gln 
65                  70                  75                  80  


Ser Tyr Val Arg Ala Leu Thr Met Asp Asn Lys Lys Arg Val Gly Trp 
                85                  90                  95      


Arg Phe Ile Arg Ile Asp Thr 
            100             


<210>  5
<211>  241
<212>  PRT
<213>  原矛头蝮（Protobothrops mucrosquamatus）

<400>  5

Met Ser Met Leu Cys Tyr Thr Leu Ile Ile Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Trp Ala Ala Pro Lys Ser Glu Asp Asn Val Pro Leu Gly Ser Pro Ala 
            20                  25                  30          


Thr Ser Asp Leu Ser Asp Thr Ser Cys Ala Lys Thr His Glu Ala Leu 
        35                  40                  45              


Lys Thr Ser Arg Asn Thr Asp His His Tyr Pro Ala Pro Lys Lys Ala 
    50                  55                  60                  


Glu Asp Gln Glu Phe Gly Ser Ala Ala Asn Ile Ile Val Asp Pro Lys 
65                  70                  75                  80  


Leu Phe Gln Lys Arg Arg Phe Gln Ser Pro Arg Val Leu Phe Ser Thr 
                85                  90                  95      


Gln Pro Pro Pro Leu Ser Arg Asp Glu Gln Ser Val Asp Asn Ala Asn 
            100                 105                 110         


Ser Leu Asn Arg Asn Ile Arg Ala Lys Arg Glu Asp His Pro Val His 
        115                 120                 125             


Asn Arg Gly Glu Tyr Ser Val Cys Asp Ser Val Asn Val Trp Val Ala 
    130                 135                 140                 


Asn Lys Thr Thr Ala Thr Asp Ile Arg Gly Asn Leu Val Thr Val Met 
145                 150                 155                 160 


Val Asp Val Asn Leu Asn Asn Asn Val Tyr Lys Gln Tyr Phe Phe Glu 
                165                 170                 175     


Thr Lys Cys Arg Asn Pro Asn Pro Val Pro Thr Gly Cys Arg Gly Ile 
            180                 185                 190         


Asp Ser Arg His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr Phe Val 
        195                 200                 205             


Lys Ala Leu Thr Met Glu Gly Lys Gln Ala Ser Trp Arg Phe Ile Arg 
    210                 215                 220                 


Ile Asp Ala Ala Cys Val Cys Val Ile Ser Arg Lys Asn Glu Asn Phe 
225                 230                 235                 240 


Gly 
    


<210>  6
<211>  110
<212>  PRT
<213>  原矛头蝮（Protobothrops mucrosquamatus）

<400>  6

His Asn Arg Gly Glu Tyr Ser Val Cys Asp Ser Val Asn Val Trp Val 
1               5                   10                  15      


Ala Asn Lys Thr Thr Ala Thr Asp Ile Arg Gly Asn Leu Val Thr Val 
            20                  25                  30          


Met Val Asp Val Asn Leu Asn Asn Asn Val Tyr Lys Gln Tyr Phe Phe 
        35                  40                  45              


Glu Thr Lys Cys Arg Asn Pro Asn Pro Val Pro Thr Gly Cys Arg Gly 
    50                  55                  60                  


Ile Asp Ser Arg His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr Phe 
65                  70                  75                  80  


Val Lys Ala Leu Thr Met Glu Gly Lys Gln Ala Ser Trp Arg Phe Ile 
                85                  90                  95      


Arg Ile Asp Ala Ala Cys Val Cys Val Ile Ser Arg Lys Asn 
            100                 105                 110 


<210>  7
<211>  244
<212>  PRT
<213>  钝鼻蝰(Macrovipera lebetina)

<400>  7

Met Ser Met Leu Cys Tyr Thr Leu Ile Ile Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Trp Ala Ala Pro Lys Ser Glu Asp Asn Val Ser Leu Gly Ser Pro Ala 
            20                  25                  30          


Thr Pro Asp Leu Ser Asp Thr Ser Cys Ala Lys Thr His Glu Ala Leu 
        35                  40                  45              


Lys Thr Ser Arg Asn Thr Asp Gln His Tyr Pro Ala Pro Lys Lys Ala 
    50                  55                  60                  


Glu Asp Gln Glu Phe Gly Ser Ala Ala Asn Ile Ile Val Asp Pro Lys 
65                  70                  75                  80  


Leu Phe Gln Lys Arg Arg Phe Gln Ser Pro Arg Val Leu Phe Ser Thr 
                85                  90                  95      


Gln Pro Pro Pro Leu Ser Arg Asp Glu Gln Ser Val Glu Phe Leu Asp 
            100                 105                 110         


Asn Ala Asp Ser Leu Asn Arg Asn Ile Arg Ala Lys Arg Ala Thr His 
        115                 120                 125             


Pro Val His Asn Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val 
    130                 135                 140                 


Trp Val Ala Asn Lys Thr Thr Ala Thr Asp Ile Arg Gly Asn Val Val 
145                 150                 155                 160 


Thr Val Met Val Asp Val Lys Leu Asn Asn Asn Val Tyr Arg Gln Tyr 
                165                 170                 175     


Phe Phe Glu Thr Lys Cys Lys Asn Pro Ser Pro Val Ser Ser Gly Cys 
            180                 185                 190         


Arg Gly Ile Asp Ala Lys His Trp Asn Ser Tyr Cys Thr Thr Thr Asp 
        195                 200                 205             


Thr Phe Val Arg Ala Leu Thr Met Glu Gly Asn Gln Ala Ser Trp Arg 
    210                 215                 220                 


Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val Ile Ser Arg Lys Asn 
225                 230                 235                 240 


Asp Asn Phe Gly 
                


<210>  8
<211>  110
<212>  PRT
<213>  钝鼻蝰(Macrovipera lebetina)

<400>  8

His Asn Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val Trp Val 
1               5                   10                  15      


Ala Asn Lys Thr Thr Ala Thr Asp Ile Arg Gly Asn Val Val Thr Val 
            20                  25                  30          


Met Val Asp Val Lys Leu Asn Asn Asn Val Tyr Arg Gln Tyr Phe Phe 
        35                  40                  45              


Glu Thr Lys Cys Lys Asn Pro Ser Pro Val Ser Ser Gly Cys Arg Gly 
    50                  55                  60                  


Ile Asp Ala Lys His Trp Asn Ser Tyr Cys Thr Thr Thr Asp Thr Phe 
65                  70                  75                  80  


Val Arg Ala Leu Thr Met Glu Gly Asn Gln Ala Ser Trp Arg Phe Ile 
                85                  90                  95      


Arg Ile Asp Thr Ala Cys Val Cys Val Ile Ser Arg Lys Asn 
            100                 105                 110 


