                         SEQUENCE LISTING

<110>  North Carolina State University
       Cruse, Glenn P.
 
<120>  EXON SKIPPING OF FCEPSILONRI AND MS4A6 IN COMBINATION FOR THE 
       TREATMENT OF ALLERGIC DISEASES

<130>  297/327 PCT

<150>  US 62/932,664
<151>  2019-11-08

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1791
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (494)..(1240)

<400>  1
attccgaagg gttctgtgct aggaacctta cacgtgttgt ctcacataat ccttaaaact       60

cagaaatgat tttaaattaa atagcacaga gaggaaaact gactggagag ggagcctttg      120

cttagattag aaaactgaag cttcaagaac agacttgcct aacaacagga aacttgtatg      180

tctcgaagtg gcaattcaca cataaggctc catgactcct gaactctcac aaatattagt      240

tggctctttt catggtttta ctgaagttgc tagaagttta cagaaaagga agtgcaggaa      300

catttcacaa atctacaatc tgtgagtatc acatcctgta tagctgtaaa cactggaata      360

aggaagggct gatgactttc agaagatgaa ggtaagtaga aaccgttgat gggactgaga      420

aaccagagtt aaaacctctt tggagcttct gaggactcag ctggaaccaa cgggcacagt      480

tggcaacacc atc atg aca tca caa cct gtt ccc aat gag acc atc ata         529
               Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile            
               1               5                   10                     

gtg ctc cca tca aat gtc atc aac ttc tcc caa gca gag aaa ccc gaa        577
Val Leu Pro Ser Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu           
        15                  20                  25                        

ccc acc aac cag ggg cag gat agc ctg aag aaa cat cta cac gca gaa        625
Pro Thr Asn Gln Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu           
    30                  35                  40                            

atc aaa gtt att ggg act atc cag atc ttg tgt ggc atg atg gta ttg        673
Ile Lys Val Ile Gly Thr Ile Gln Ile Leu Cys Gly Met Met Val Leu           
45                  50                  55                  60            

agc ttg ggg atc att ttg gca tct gct tcc ttc tct cca aat ttt acc        721
Ser Leu Gly Ile Ile Leu Ala Ser Ala Ser Phe Ser Pro Asn Phe Thr           
                65                  70                  75                

caa gtg act tct aca ctg ttg aac tct gct tac cca ttc ata gga ccc        769
Gln Val Thr Ser Thr Leu Leu Asn Ser Ala Tyr Pro Phe Ile Gly Pro           
            80                  85                  90                    

ttt ttt ttt atc atc tct ggc tct cta tca atc gcc aca gag aaa agg        817
Phe Phe Phe Ile Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg           
        95                  100                 105                       

tta acc aag ctt ttg gtg cat agc agc ctg gtt gga agc att ctg agt        865
Leu Thr Lys Leu Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser           
    110                 115                 120                           

gct ctg tct gcc ctg gtg ggt ttc att atc ctg tct gtc aaa cag gcc        913
Ala Leu Ser Ala Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala           
125                 130                 135                 140           

acc tta aat cct gcc tca ctg cag tgt gag ttg gac aaa aat aat ata        961
Thr Leu Asn Pro Ala Ser Leu Gln Cys Glu Leu Asp Lys Asn Asn Ile           
                145                 150                 155               

cca aca aga agt tat gtt tct tac ttt tat cat gat tca ctt tat acc       1009
Pro Thr Arg Ser Tyr Val Ser Tyr Phe Tyr His Asp Ser Leu Tyr Thr           
            160                 165                 170                   

acg gac tgc tat aca gcc aaa gcc agt ctg gct gga act ctc tct ctg       1057
Thr Asp Cys Tyr Thr Ala Lys Ala Ser Leu Ala Gly Thr Leu Ser Leu           
        175                 180                 185                       

atg ctg att tgc act ctg ctg gaa ttc tgc cta gct gtg ctc act gct       1105
Met Leu Ile Cys Thr Leu Leu Glu Phe Cys Leu Ala Val Leu Thr Ala           
    190                 195                 200                           

gtg ctg cgg tgg aaa cag gct tac tct gac ttc cct ggg agt gta ctt       1153
Val Leu Arg Trp Lys Gln Ala Tyr Ser Asp Phe Pro Gly Ser Val Leu           
205                 210                 215                 220           

ttc ctg cct cac agt tac att ggt aat tct ggc atg tcc tca aaa atg       1201
Phe Leu Pro His Ser Tyr Ile Gly Asn Ser Gly Met Ser Ser Lys Met           
                225                 230                 235               

act cat gac tgt gga tat gaa gaa cta ttg act tct taa gaaaaaaggg        1250
Thr His Asp Cys Gly Tyr Glu Glu Leu Leu Thr Ser                           
            240                 245                                       

agaaatatta atcagaaagt tgattcttat gataatatgg aaaagttaac cattatagaa     1310

aagcaaagct tgagtttcct aaatgtaagc ttttaaagta atgaacatta aaaaaaacca     1370

ttatttcact gtcatttaag atatgtgttc attggggatc tcttgatttg cctgacattg     1430

acttcagcaa aagcacgggg ctgtaaatta ccatttacta gattagccaa atagtctgaa     1490

tttccagaaa acaaggcaga atgatcattc ccagaaacat ttcccagaaa atgtttccca     1550

gaaaactaga cagaatgatc attcaatgga tcacagtgaa gcaaaggaca caacttttta     1610

ttgtacccct taattgtcaa caggagttaa ctgatttgtt gtggtgctca gactttttta     1670

tacaggtgct agtgttttat cctatgtatt ttaactcatt agtgcataaa ggcaagcccc     1730

atataatgaa gtctcagggt atatgaaagt agctggcttc aaaataaaat ttttgagtgc     1790

a                                                                     1791


<210>  2
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile Val Leu Pro Ser 
1               5                   10                  15      


Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln 
            20                  25                  30          


Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu Ile Lys Val Ile 
        35                  40                  45              


Gly Thr Ile Gln Ile Leu Cys Gly Met Met Val Leu Ser Leu Gly Ile 
    50                  55                  60                  


Ile Leu Ala Ser Ala Ser Phe Ser Pro Asn Phe Thr Gln Val Thr Ser 
65                  70                  75                  80  


Thr Leu Leu Asn Ser Ala Tyr Pro Phe Ile Gly Pro Phe Phe Phe Ile 
                85                  90                  95      


Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu Thr Lys Leu 
            100                 105                 110         


Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser Ala Leu Ser Ala 
        115                 120                 125             


Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala Thr Leu Asn Pro 
    130                 135                 140                 


Ala Ser Leu Gln Cys Glu Leu Asp Lys Asn Asn Ile Pro Thr Arg Ser 
145                 150                 155                 160 


Tyr Val Ser Tyr Phe Tyr His Asp Ser Leu Tyr Thr Thr Asp Cys Tyr 
                165                 170                 175     


Thr Ala Lys Ala Ser Leu Ala Gly Thr Leu Ser Leu Met Leu Ile Cys 
            180                 185                 190         


Thr Leu Leu Glu Phe Cys Leu Ala Val Leu Thr Ala Val Leu Arg Trp 
        195                 200                 205             


Lys Gln Ala Tyr Ser Asp Phe Pro Gly Ser Val Leu Phe Leu Pro His 
    210                 215                 220                 


Ser Tyr Ile Gly Asn Ser Gly Met Ser Ser Lys Met Thr His Asp Cys 
225                 230                 235                 240 


Gly Tyr Glu Glu Leu Leu Thr Ser 
                245             


<210>  3
<211>  13060
<212>  DNA
<213>  Homo sapiens

<400>  3
attccgaagg gttctgtgct aggaacctta cacgtgttgt ctcacataat ccttaaaact       60

cagaaatgat tttaaattaa atagcacaga gaggaaaact gactggagag ggagcctttg      120

cttaggtagg caactttaac tggtttatta gcacattccc ctgaagggaa agggggtgtg      180

attgctcctg aagagaccaa agagactggg ctccttttta atcaaagctc aggaggagag      240

ctgcattcca ctgtttcaca gatgctgtga gggtgacaaa gatgcagggc acccactgga      300

aacacagacg gcactctgcg aaagaggaag gggcgccagg agcttgggtg agcaaggttg      360

gaggtgattc tgcccctctc cccaggcttt ctgtgtgagt ccattcctcc tctcagattt      420

attgttagaa cttaagacaa gccaattaca tttcataatg tctgtgtcat tcagacgctg      480

agaactaatc cagccttcta aatggtgctt cttaactcct ttcttcaaca ggagagttaa      540

tgtgtggaat taagtgcaga atccatggcc ctctgtggtg acggtgatgg ttcaggttgt      600

gtttctgggt tcattctgga agctccccca aggaaaggag gaaggaagct tgcagggtgg      660

ggctttgcca ttgccctgac tggctctggt ttccttgcct gatacattga agtcagcttc      720

caaagaatgc cacccaaggt tttgaagggg cacagtgcct ctgtcctcac aaaaccagcc      780

tgcatatgag tttactgaat tcatttaggt cctgctgaat ctttcccatt tgttccttct      840

ctgtttcaat atttcaatgc ttccctggag gggcccaacc tttctggagg gcaaagatct      900

gttgttagag aaaaagagca gccagaggag gaagatgact tgagggtagg cagcagttgg      960

gcaatcagta ttgaaaggtt gctttcagcc tgccaagact tggggaatta gaaaagcaag     1020

ataaaacaaa acaaacaaac aaactatata tataaaaaac aattttttaa aagttttttt     1080

atgttctata ttactattag ctatatatta atgaatgttc ctttaaagca gtgtagtcat     1140

tattgctatt attattatta tggttagtta tagacagtgg aatattgttc tttctctata     1200

ttatgattac tagcactatt actgttatta gttacatgtt attgaaagct tcaaagcagc     1260

ataggctttt tataaatatt tttgctcatc tttatgacaa ttctccagtg ttggtattgc     1320

tcctctattt aacagattag aaaactgaag cttcaagaac agacttgcct aacaacagga     1380

aacttgtatg tctcgaagtg gcaattcaca cataaggctc catgactcct gaactctcac     1440

aaatattagt tggctctttt catggtttta ctgaagttgc tagaagttta cagaaaagga     1500

agtgcaggaa catttcacaa atctacaatc tgtgagtatc acatcctgta tagctgtaaa     1560

cactggaata aggaagggct gatgactttc agaagatgaa ggtaagtaga aaccgttgat     1620

gggactgaga aaccagagtt aaaacctctt tggagcttct gaggactcag ctggaaccaa     1680

cgggcacagg taggtaatgc tggaagactt ttctcatctc actattccct tgccgtgacc     1740

tcattagagg agtaatttaa cttgaaactc cttgacagca gttaagagac actagggcct     1800

tttggaaata gagtgggcaa atggaaggag tatctgtttt taactctgtg tccgctgtat     1860

tctaattgca taaactcagt gagtcactta cctaaggttg tgtaattaat gggagcagag     1920

ctcttgtctc ttcaaatgtg tttagaccat ttgtaaactg ggcggtctgt gctttgagaa     1980

tggtgccgtg aaaagggatc caagctgagc ttagcaacaa ataccacaac ctacttggtc     2040

tttatgctaa aaagtgggga ggaccaacga cgcgagccta tgtgttatga gtccaagact     2100

tgttctcata ccactgcatg cagctgtttc tccagcctga gtaaactcag acacaggctg     2160

gcaatgccag gtgggaaatt aggaagaggt agaatgatct agagatttat gcaaaggctt     2220

cagactccag gaaagctgag atccaagact ggttttacag cttcccggct gtgtgaacca     2280

gggtgaacaa taagggtaac tgcaaatatt tcttcagcat taactctggg ccacacatat     2340

atgcaatagg tatattattt gcattcataa cttaaacttt attttgcatt ttcttattta     2400

ttacatgttt ttactaactt actaacatgc agagctgttg taaggattaa aagcactgca     2460

gggtaaaaat taagaatgtg tctggtaaaa tatgataaac atatctgagt gctaataaat     2520

agtattatta aacaagaaat aagtaagcag agttcattta ttagtctgaa aattcatcaa     2580

atatatggca atacagttgt tgtcagtagg actagaggaa agggaggttg ttgcatattg     2640

caaattttgt gtgaccattt gcctctggac attgagacct ctcaagattc atgttgctgc     2700

caccctgtga tgtgtttatt atctataatg gactgtgtca aacattatgg aaaaatcctc     2760

atgaaaccaa gattgtgtgg ttttcactgt tccatactat cagtttcttt ctctaatgga     2820

caggccaagc ctagactaat tggcaaagac tgagttactg tttttggagt cagaacctgg     2880

gagctctgta ctttttaaga gctaaatcta ttttttctta catagttggc aacaccatca     2940

tgacatcaca acctgttccc aatgagacca tcatagtgct cccatcaaat gtcatcaact     3000

tctcccaagc agagaaaccc gaacccacca accaggggca ggatagcctg aagaaacatc     3060

tacacgcaga aatcaaagtt attggggtaa atctaattca gaacgtgttg gagaggggtt     3120

gggggaagtg ccaagagatg atatatgtct tgggactgga catctgtcgt gagtgtggag     3180

accctaaaat tttgctagag ggactttagg gtagaagcca cttggagaaa actgtcccag     3240

aacttttcca caagaggttg tcttaaaaat atattttccc ttattctgaa tatgaggaat     3300

tgattttcta ttgttgtctt tgtattttta caatacagtg cttttctata ttttctttta     3360

caaaagtaat ggtggtaaat aatgacatat tgtgtgtatg tgtatatatt ccacaactgc     3420

atgcttaata atccaaactg actttttgca aataattttt ccctcactgc aaattagagg     3480

aaatatacaa ctccttttcc tcttttctcc taacgttttt gagaatggaa atgatattca     3540

ccttttgttt gtctgtttct cctctcaccc agaatttatt aaagaagctg tattgcatga     3600

agggaggaga gaaagaaggg atctatcttg gattgggagg gaaacacaga gttttggttt     3660

ctagaattgc ctctgcactt atgtgatctg aggtgaggca ctctgtttga ctggatttca     3720

ggacctggtg ggactggttt ccttgcctca tgtacaatca catgggtttc tatgaggctc     3780

atgtgacata aggtctagaa aactttttgg taaatgataa tagagctgtg aatctctgag     3840

gtggatgtca ggaaggaaaa ctacctccta agacagagct tcagttatac atgagaacat     3900

gcagtatttg gtttctgtcc ctgtgttagt ctgctaaggg ggatggcctc taaatgatga     3960

gaacacatgg acacgtagaa cagaacaatg cacactgagg cctttcagag ggtggagggt     4020

gggaggagag agaggatcag gaaaaataac taatggatac taggcttaat acctgggtga     4080

tgaaataatc tgtacagcaa acccccatga cacaagttta tctatgtaac agacatgcag     4140

ttgtaccctt gaacttaaaa taaaagctaa aaataaaaga gcttccagag cttcagctat     4200

agggttgtga actgcagttt ccgaggaagt gaccaaaggg gcaaactcca tgtccagtgg     4260

agtctgggag atgaggggag ggccttctgc actgccaata ctgcagagaa tgtgggggct     4320

ttcagatgtc ccctgttttc agagagatag aaagagagtt aactagtcat ggacttagag     4380

gtcctgagag ctgggaaagt aaatctcagc acttgctgtg agctggaagc aagtctcatg     4440

agcagaccag ggcctgagag gcagaaatgc agaagccttc ctgagcacct gccagacacc     4500

tgagactgtg gcttctgtgg cagagctgca caccctccag gatgtctttt catatttctc     4560

actccagagt ttccacaggg tttgtatcct cattaggatc ttgcagaagg cgataatgca     4620

ttagtgccat gggagcggca aaaaggccct gtctttacaa atgctggttt tcatcctcaa     4680

tctcactttc tcttcccaca gactatccag atcttgtgtg gcatgatggt attgagcttg     4740

gggatcattt tggcatctgc ttccttctct ccaaatttta cccaagtgac ttctacactg     4800

ttgaactctg cttacccatt cataggaccc ttttttgtga gtagagtttc tgaggagggc     4860

aggatggggc aaagagggga ggaagatgcc aatagcttag acttcccacc tgccagcttg     4920

ctatgtttga tctgccagga gcaaggagtc aacggtgaat cttgttctcc tgtcgggtag     4980

gatgacaggg gttgcttgat tttagatcaa tttcttatca gactcaaata aacatttctt     5040

ttgaagatca tcttattctt cacattatca tcttgagcta tgatgaagct agtgacttct     5100

ctccaggttt aggcgaaaaa aaaatccatg aattaggata aagttgggaa ggaacatttt     5160

atacaaaaaa aaaaaagagc ataaatggaa gacatcacac actcacagag aaaccacact     5220

gttatccccc ccatgcttgt ggggatcatg gaggaaggag aacttacacc tctgagcatt     5280

ttgaaaatac ttttactgca ttgactgatt cccaggtaag gctgagcaga tatctatgcc     5340

cagtgattga caggaaattc ctctgaaata gctgcaagtc tggagtttca aaaggactta     5400

gtagtccttt cctcagagaa ctgctttctc taagatgggg gctttctcat aggtaagttt     5460

ccctttcata gatgtttttt ccttcaactt cctgcaattc agtagctatt tgtttttctt     5520

acatttgtgt atttgatgca ccaagaagtc cacctttttg tgtatcttgt ccatttttct     5580

tgtcttatta actaaagtta cacttggatt tggatttcat tggttttccc caaatgacct     5640

ttttctgttc caagatccat gccaagctac tacattacac tacattacat tttgtcatga     5700

tgtctcctca gggtcctcta ggctgtctaa gattttcctt ttccttgaga actttgatag     5760

ttttgggtag cgctggctga gatttttata gaatgttcct aaatttgggt ttgtctgatt     5820

tttttttttg atgtttagag tatggtgatg aatttttggg tggtgatgat gaggtaaagc     5880

accattttca tcaagtcgta tcaagggtca tgctaccaac ataatgtcac tgacacaatt     5940

aaccttgatt atgtggttgg ggtagtattt tccagatttc tcctctgtaa aattactact     6000

ttttttttta accattgctt ttatgtcctt ccctagagaa catcttacac caaaactgtc     6060

tcattttatt aaaaaaacaa aaattatttc ctggctttta aggtcttttt ttgtttagtg     6120

ggatattttt tgtttattag gatatatttc tgctatcttt tttttttctg atgttatctg     6180

aatgttatat ggacaaaggg acaaatctat gtatttaaat ggaacttacc tcattgatca     6240

ctggtttctc agggattttc ccatgagagt tgtctataaa cattgtgata gtgacgtcga     6300

aggtactctg tacatggaat ctgacctgac cattttctct tttatcttag tttatcatct     6360

ctggctctct atcaatcgcc acagagaaaa ggttaaccaa gcttttggtg agtaagagag     6420

ctataaccca caacccaatg gatcaaaata aaacttagac agaactcttt aaggctagtc     6480

tttctacttt gaaaagttga aaactcagtt ccagagcagt tggttgttgt tagaattagg     6540

agctgggcct ggatcctctg tatccttgtt cagagaacat ttctccaatt attgtaccct     6600

acatcaaagt ctgcattcag gggattataa tattccctct gcccatgccg aagaatgtat     6660

cacagagaaa ttgtgcctgt ttatgaggtt ctttcggtga taactggcct tcaaattcag     6720

gttttcagtg gcaaggaagc tgacagtgtt ataaagcggt ctattggttg gggtccattc     6780

tttaagccca ggtgttacaa cccttgaaaa aaaaatgagt caaagtgttg ttcatgtgag     6840

gtatccaaag tagacacaga ggctactaca gtatactaca ttacatttag gcctgatgtc     6900

tcctcaggtt cctttagact ttctcagatt ttccttttcc ttgaggactt caatagtttt     6960

gggtagtgct ggctgactgt atcctttcat ctatctcacc agaagtataa tacttttatt     7020

ttgtttgagt ataaattctt gcaccctaaa aagttgtcct tagtcatttg tattggctaa     7080

caaaaaaaca aaacaacaac aacaaaaaac aaagctttac ccgtctttat cccttattcc     7140

agcaaaaact agagttggaa gtggcaggga gacaaagcct ggattatagg gagaatcttc     7200

tcttgtcttt aaagtttcat taagtcttcg ctcaatccat tatctctcaa ggggttgatg     7260

ttggagatta tgtgagagaa tgtcatacca tgcaattgca ccgagactca atttggaagc     7320

tctggctaca aaaatctccc aaagccagca aggaagtgag aaacggcatc cagaaaaatg     7380

ccaattcttt ttctcatcgg tatttagaga ttattatttg gaaccctcag ttagactcgg     7440

aactactaac tagatctgtg ctgtttaatt taactttctt tgaggatgga aatgaaatgt     7500

aactttctat gatgatagaa atgaaatgta actttctatg atgatggaaa tgcactacag     7560

ctgtactgta caatatggca gtcacatgtg gctatcgatg atgtgaaata tagtgcaact     7620

gaataaaaat ttctcttaat tttactttaa atatagatag tctatgtggc tattggcaac     7680

catactgagt agcctggcac aagggtagtg ctttcaaact tttaggagga aatatatggg     7740

cctgttactc cagagaacaa tcccacagtg aacatgcagg aagctcaagg atgcaggatg     7800

tggtctcggg gtgggctcag acttaccaga gacatcgagg ctttagcgag ttctactctt     7860

gtcacacatt gcaccagccc tttttgagat tgaagaagag tgccatctca agacaaatct     7920

agcttattct aagaaatata gactctaggc atcaagaata ctactggcta ctaggaggcc     7980

caggagtgta cacttcagtc attatgttgg gaaattgggg tcccagagta tcaactggtg     8040

agttcctaaa agaagaagtg cccatgtggg attaagtaac attctactgt atggctgtga     8100

ggtgtgccct ggagcctacc tacctgtaac tatagctctc agagtactct tagctcaatt     8160

ctcttttctg tgtgagttgg agtacaaaag aagtcacttc tgaggttagt ttatctattc     8220

ccttcacttc ataaatgtat aaatgagaac cagagtggga aataaaatca aggaactgat     8280

tacccaaggg aataaaccaa ggcaagtcta gtactgtgac ttcaatattc tgacctccag     8340

ttcagacctt tttcttgtac ttcccgctgc ctcccacaca ttacaccatc cttgggcctg     8400

cacctagacc tctgcccaca gccaccccat actgcactca gtgtggccaa tcatatgcct     8460

gcccatgttc cagggcctgc ctgagactca gaaccacccc ctcactcatc tttgagaggt     8520

gtgcttttga gagaagcaat gggcaggcga gagtgagcta ttaggttggt gcaaacataa     8580

ttgtggtttt atggcaaaaa ccacaattac ttttgcacca tgctaataca tgatctatct     8640

tttccatgtg gctgatgctt ccgccagggg tttttgagtt gagcgagaga gaaactgcat     8700

ctggtacgtt gccaccttca ctttgggtca cgctctcttg gtaatgttgc aggtaaagcc     8760

tcatgaaagc cctgctatct gtcctgggga aagaatttag gagagtaaca ttctctacca     8820

caccactgag gtcctgctta aggtgaacca gttcgtatag tcattcattc agccaagaat     8880

taccctggag attgagagat ttttgctgga cactggagag gcatacagca ataaatgatc     8940

aatcccagac ctcctgaggg gacagataag ggaataactt acaatttaat ggcaaagatg     9000

cataacagat tcatgagtca ttagcaatga tccttaccca acatttctct ttcaggtgca     9060

tagcagcctg gttggaagca ttctgagtgc tctgtctgcc ctggtgggtt tcattatcct     9120

gtctgtcaaa caggccacct taaatcctgc ctcactgcag tgtgagttgg acaaaaataa     9180

tataccaaca agaagttatg tttcttactt ttatcatgat tcactttata ccacggactg     9240

ctatacagcc aaagccagtc tggctgtaag tatttttaga tgggatgttc taatcttatg     9300

aggtattcaa aagccttgat ttcttgttat tccttctttt gaaaatctct ctattggttc     9360

tggtttgggc atctggggga aagccaggtt tatgtaaatc aaaggggact acagggatga     9420

gattaagggg attacatact aatagagtgg aattgaaaat gttaaataag gttgatgatg     9480

aaaaactaaa acttactgtt tgtagaggtt cttaattatc aaactaatcc aattttggag     9540

gcataaatta tgagtttatc aaaatgagaa tcttggtaca tggagtggtg aattaagaat     9600

ggaaacagag cagaaagacc caggagatca gaataggcca acaaggaaac agtatgtgtg     9660

catggtaagg agttaatttg gtttgagaag acatcagatt cagtactaag aaaaagagga     9720

taggaaatat gggatgagaa gataagggct tcttcttcta atgatcacaa taatgaataa     9780

tactgatcag gtgagaatgc aacattattg ttgctttttg ttatagctga aagaagtgtg     9840

atatattaaa tcaggagata agaaatatag ggagatggag agtgtaattg agaatgattg     9900

caggagaatt ctatctcttt ggaagaagaa aaataatgaa gtttggctaa tagaaataat     9960

atgtctgaag ttgaaagatt aaggggcatg tgcatggtca gcaacacatt gagagaaaaa    10020

caggcaacat aagagtaaag ggacggctgg gtcagtggct cacccctata atacaagcat    10080

tttgggaggc cctggtgcat ggatcacgag gtcaggtgtt caagatgagc ctggccatga    10140

cggtgaaacc ccatctctac taaaagtaca aaaactagct gggtgtggtg gcgggcagcc    10200

gtaatcccag ctacttggga ggctgaggcg gagaattacc tgagcctggg aggtggcgga    10260

ggttgcagtg agctgagatc acgccactgc actccagcct gggtgacaga gcaagactcc    10320

gtctcaaaaa aaaaaaaaaa ggaataaaga aattgcagaa tatttgttgt cctgcaatca    10380

taaaaacaag ataagccaag aactcagctg gaagatggac agatagaaag gtctggtcaa    10440

agtcatgttt gtatagcact cattataaag agggccttgc tcccaaggta atggtataat    10500

gagaaaaagt acaagtaaat gaggctgaca gcaattggca cagattaata cctggcacag    10560

ccaattccac cttgggaaaa attctgaaga gaaatttcag agaaatttgg tagtgataaa    10620

gtataaattc atgatgggac gattttacat tggaaataag agagattctg tcaagtttgc    10680

ttgctggaac aatttccagt aatggaaaaa gttatatctt ctctttaact gtgtataaat    10740

accacaaacc aaagtttcat gtgatcaaat tatttccgtt tattatcaga tggccagttc    10800

tgcacaaaga atgtctcagg acagaaatga tagaattcat tcttgtgagt tggtgttggt    10860

gattagcaac tctgacagtt tactaccttc actgtttttt tctaagcctt acagttacac    10920

ccccaaaaaa aagaaaaaaa agaaaaaaca acaaagaaac aacaacaaaa atcaagaaga    10980

aatacaaagg ggttcagata catagacagg gatgtcaata ctaaatttta caaaggactt    11040

gcacagtcaa aacctccttg atccttacaa atttctgaga aagaaatgtt agtatgcatg    11100

tttgatacat gaggaaacag gagctagaga aagagagaga cttgtccagg cttacacagc    11160

tactaagcag taaaggtgag actggaacgg agctgctgat tctcagtcct gggagttatt    11220

acgccactct gctttcttac cgagtgaaca atgtcatcag aactatggat gtctcaaaga    11280

agtaagaaat aagtgtatga agtagattag ttgatttaat tactattcat ctccctttct    11340

cctctcaagg aaatgagtta aggggttgaa ttaagacaat tgtgaggtgt gggaggagca    11400

gttttatctt cctgatggtg tcctttcttc attctctaat ggttgaggtg gtcttcatct    11460

ctatggtcac ctctcaacta ggcatgaagg cttcagctga cctaagcaac atcaatcttt    11520

tatttcttga ctttcaggga actctctctc tgatgctgat ttgcactctg ctggaattct    11580

gcctagctgt gctcactgct gtgctgcggt ggaaacaggc ttactctgac ttccctgggg    11640

tgagtgtgct ggccggcttc acttaacctt gcctagtgta tcttatccct gcactgtgtt    11700

gagtatgtca ccaagagtgg tagaaggaac aatcagtcag tcatgagata cacatgggag    11760

ggcatttgca ttgtgatgga agacagagaa gaaaagcaga tggcaattga gtagctgata    11820

agctgaaaat tcactggata tgaaaatagt taatcatgag aaatcaactg attcaatctt    11880

cctattttgt cagcgaaggg aatgagactc tgggaagtta aatgactggc ctggcattat    11940

gctatgagtt tgtgcctttg ctgaggacac tagaacctgg cttgcctccc ttataagcag    12000

aaacaatttc tgccacaacc actagtctct ttaatagtat tgacttggta aagggcattt    12060

acacacgtaa ctggatccag tgaatgtctt atgctctgca tttgcccctg gtgatcttaa    12120

aattcgtttg cctttttaaa gctatattaa aaatgtattg ttgaatcaaa cccctatgga    12180

cttatggctt tatttaactg aattaaaaag ccttgattta tccaaaattg tattatagag    12240

tgtagaatga atactagggt gataaattgc aattatttga agaacctggt gatatgctct    12300

acttatcttg gattagctaa gaattctatg tatacagttg gaaaaatggc atatatacat    12360

ctatcttgaa cctgattgaa gtctgaagac ctaacatatt ttgtttcttc tagagtgtac    12420

ttttcctgcc tcacagttac attggtaatt ctggcatgtc ctcaaaaatg actcatgact    12480

gtggatatga agaactattg acttcttaag aaaaaaggga gaaatattaa tcagaaagtt    12540

gattcttatg ataatatgga aaagttaacc attatagaaa agcaaagctt gagtttccta    12600

aatgtaagct tttaaagtaa tgaacattaa aaaaaaccat tatttcactg tcatttaaga    12660

tatgtgttca ttggggatct cttgatttgc ctgacattga cttcagcaaa agcacggggc    12720

tgtaaattac catttactag attagccaaa tagtctgaat ttccagaaaa caaggcagaa    12780

tgatcattcc cagaaacatt tcccagaaaa tgtttcccag aaaactagac agaatgatca    12840

ttcaatggat cacagtgaag caaaggacac aactttttat tgtacccctt aattgtcaac    12900

aggagttaac tgatttgttg tggtgctcag acttttttat acaggtgcta gtgttttatc    12960

ctatgtattt taactcatta gtgcataaag gcaagcccca tataatgaag tctcagggta    13020

tatgaaagta gctggcttca aaataaaatt tttgagtgca                          13060


<210>  4
<211>  3648
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (103)..(837)

<400>  4
aacccatttc aactgcctat tcagagcatg cagtaagagg aaatccacca agtctcaata       60

taataatatt ctttattcct ggacagctcg gttaatgaaa aa atg gac aca gaa         114
                                               Met Asp Thr Glu            
                                               1                          

agt aat agg aga gca aat ctt gct ctc cca cag gag cct tcc agt gtg        162
Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu Pro Ser Ser Val           
5                   10                  15                  20            

cct gca ttt gaa gtc ttg gaa ata tct ccc cag gaa gta tct tca ggc        210
Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu Val Ser Ser Gly           
                25                  30                  35                

aga cta ttg aag tcg gcc tca tcc cca cca ctg cat aca tgg ctg aca        258
Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His Thr Trp Leu Thr           
            40                  45                  50                    

gtt ttg aaa aaa gag cag gag ttc ctg ggg gta aca caa att ctg act        306
Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr Gln Ile Leu Thr           
        55                  60                  65                        

gct atg ata tgc ctt tgt ttt gga aca gtt gtc tgc tct gta ctt gat        354
Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys Ser Val Leu Asp           
    70                  75                  80                            

att tca cac att gag gga gac att ttt tca tca ttt aaa gca ggt tat        402
Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe Lys Ala Gly Tyr           
85                  90                  95                  100           

cca ttc tgg gga gcc ata ttt ttt tct att tct gga atg ttg tca att        450
Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly Met Leu Ser Ile           
                105                 110                 115               

ata tct gaa agg aga aat gca aca tat ctg gtg aga gga agc ctg gga        498
Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg Gly Ser Leu Gly           
            120                 125                 130                   

gca aac act gcc agc agc ata gct ggg gga acg gga att acc atc ctg        546
Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly Ile Thr Ile Leu           
        135                 140                 145                       

atc atc aac ctg aag aag agc ttg gcc tat atc cac atc cac agt tgc        594
Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His Ile His Ser Cys           
    150                 155                 160                           

cag aaa ttt ttt gag acc aag tgc ttt atg gct tcc ttt tcc act gaa        642
Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser Phe Ser Thr Glu           
165                 170                 175                 180           

att gta gtg atg atg ctg ttt ctc acc att ctg gga ctt ggt agt gct        690
Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly Leu Gly Ser Ala           
                185                 190                 195               

gtg tca ctc aca atc tgt gga gct ggg gaa gaa ctc aaa gga aac aag        738
Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu Lys Gly Asn Lys           
            200                 205                 210                   

gtt cca gag gat cgt gtt tat gaa gaa tta aac ata tat tca gct act        786
Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile Tyr Ser Ala Thr           
        215                 220                 225                       

tac agt gag ttg gaa gac cca ggg gaa atg tct cct ccc att gat tta        834
Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro Pro Ile Asp Leu           
    230                 235                 240                           

taa gaatcacgtg tccagaacac tctgattcac agccaaggat ccagaaggcc             887

aaggtcttgt taaggggcta ctggaaaaat ttctattctc tccacagcct gctggtttta      947

cattagattt attcgcctga taagaatatt ttgtttctgc tgcttctgtc caccttaata     1007

ttctccttct atttgtagat atgatagact cctatttttc ttgttttata ttatgaccac     1067

acacatctct gctggaaagt caacatgtag taagcaagat ttaactgttt gattataact     1127

gtgcaaatac agaaaaaaag aaggctggct gaaagttgag ttaaactttg acagtttgat     1187

aatatttggt tcttagggtt tttttttttt tttagcattc ttaatagtta cagttgggca     1247

tgatttgtac catccaccca tacccacaca gtcacagtca cacacacata tgtattactt     1307

acactatata taacttccta tgcaaatatt ttaccaccag tcaataatac atttttgcca     1367

agacatgaag ttttataaag atctgtataa ttgcctgaat caccagcaca ttcactgaca     1427

tgatattatt tgcagattga caagtaggaa gtggggaatt ttattaagtt actcgttgtc     1487

tggggaggta aataggttaa aaacagggaa attataagtg cagagattaa catttcacaa     1547

atgtttagtg aaacatttgt gaaaaaagaa gactaaatta agacctgagc tgaaataaag     1607

tgagtggaaa tggaaataat ggttatatct aaaacatgta gaaaaagagt aactggtaga     1667

ttttgttaac aaattaaaga ataaagttag acaagcaact ggttgactaa tacattaagc     1727

gtttgagtct aagatgaaag gagaacactg gttatgttga tagaatgata aaaagggtcg     1787

ggcgcggagg ctcacgcctg taatcccagc cctttgggag gccgaggtgg gcagatcacg     1847

aagtcagtag tttgagacca gcctggccaa catagtgaaa ccccgtctct actaaaaata     1907

caaaaaaaaa attagctggg tgtggtggca gtcacctgta gtcccagcta cttgggaggc     1967

tgaggcagga gaatcgcttc aacctgggag gcggaggttg cagtgagccg agatcgcacc     2027

agtgcactcc agccttggtg acaatgggag actccatctc aaaaaaaaaa aaaaaaaaaa     2087

aaaagataaa aagtcagaaa tctgaaaagt ggaggaagag tacaaataga cctaaattaa     2147

gctcattttt aggctttgat tttggggaga caaagggaaa tgcagccata gagggcctga     2207

tgacatccaa tacagagttc tggtaaagat aaaatttgat acaggtttgg tgtcattata     2267

agagaaatca ttattaaatg aagcaagtta acactctaag agaattattt tgagatagaa     2327

gtgaagctaa gctaaacttc acatgcctat aattggaggg aaaaactaag gataaaatct     2387

agcctagaag atacaataat tagtcataaa catgcattgt gaaactgtag agagcaggta     2447

gcccaaaata gagaaagatt agataaagag aaaataagta tccatcagag acagtatctc     2507

taggcttggg caagagaaaa gtccacagtg ataagcaact ccacctaagg catgaatatg     2567

cggcagagaa aacagcaata gtgaatgaat gcaaaaggtg ctgagaaatt ccacacatga     2627

gtattgtgat gagtaaatga ataaaacatt tgcaaagacc tttagagaaa gagaatggga     2687

gcatatgtga gaaataagat agttgattat gaatagaagg tagtgaagaa aagcaagcta     2747

agaaaaaatt ctgtttataa aagaaggaaa agatagttta tgtttttagc ctaagtataa     2807

gagtcctaca gatggactga aaaaaatcag tctgagagta ttagtcacaa ttaatgaaat     2867

aattacattt tatgtattga ggatgccaag attaaaaggt gacaggtaga tgttaatttc     2927

cctagattgt gaaagtgatc acgacaatca cacaacaaat aattaagtga cttggtatgc     2987

tttatttaat tgtagggcct gaggttttcc attctcattt ttctaaaata caattttgtt     3047

tctccaaatt tgacagcaga ataaaaaccc taccctttca ctgtgtatca tgctaagctg     3107

catctctact cttgatcatc tgtaggtatt aatcacatca cttccatggc atggatgttc     3167

acatacagac tcttaaccct ggtttaccag gacctctagg agtggatcca atctatatct     3227

ttacagttgt atagtatatg atatctcttt tatttcactc aatttatatt ttcatcattg     3287

actacatatt tcttatacac aacacacaat ttatgaattt tttctcaaga tcattctgag     3347

agttgcccca ccctacctgc cttttatagt atgcccacct caggcagaca cagagcacaa     3407

tgctggggtt ctcttcacac tatcactgcc ccaaattgtc tttctaaatt tcaacttcaa     3467

tgtcatcttc tccatgaaga ccactgaatg aacacctttt catccagcct taatttcttg     3527

ctccataact actctatccc acgatgcagt attgtatcat taattattag tgtgcttgtg     3587

acctccttat gtattctcaa ttacctgtat ttgtgcaata aattggaata atgtaacttg     3647

a                                                                     3648


<210>  5
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210>  6
<211>  9804
<212>  DNA
<213>  Homo sapiens

<400>  6
aacccatttc aactgcctat tcagagcatg cagtaagagg aaatccacca agtctcaata       60

taataatatt ctttattcct ggacagctcg gttaatgaaa aaatggacac agaaagtaat      120

aggagagcaa atcttgctct cccacaggag ccttccaggt aggtacaagg tattattttt      180

ttctaccctc agtcacttag tggcagggga agtcatagtc acggtgctta ggagatgaaa      240

ctttattgat ttaggcatgg atccatctag tttaattaat atattgggta tgaggaagct      300

acttgctgta ctttccatgt ggttctctct ccctggagag gaacattttt actcagcttg      360

caaactggaa atagattttc tcacattaga agctcatttt ctgggtatga gacaggagag      420

ttcatactgt gtatgtagat ctctggcttc tgggtctgac atgtgctgag ggacacatat      480

ccttcacaca tgcttttata aatacttgat aaagtaacct gcttcttgat tggtctttat      540

aatccataag ctgtgggatg cttctctgaa gatgaaaata gtaatagagt cccatctagc      600

tattcaaagc cattccttca ttgtattctg tgcacatgaa gttggggttt gttactgaca      660

aaatatattc agatacattt ctatgttaaa aggattgtga gatgcatagg taaatgtgtt      720

tattttcagt tttacttgtc aacatagatg aatgagaaag aacttgaaag taacactgga      780

ttaagaatag gaaaatttgg catggatttt gctccatttt gtcccatcta atcacttgga      840

tagtgttcag gtgttcttgg tcagttactt ggatgctctg agctttagtt tcttggtgat      900

tacaatgaag atttgaatta caggatggct ttgaaaaaat aaacaaaact cccctttctg      960

tctgtcgaga atgttgcaca gggagttaca gaatgttctc atgactgaat tgcttttaaa     1020

tttcacagtg tgcctgcatt tgaagtcttg gaaatatctc cccaggaagt atcttcaggc     1080

agactattga agtcggcctc atccccacca ctgcatacat ggctgacagt tttgaaaaaa     1140

gagcaggagt tcctgggggt gagtgagcct cctccaactt tgactagagt aagggttggg     1200

tctagaaaag aatattgagt tgcatcaact gttttcccac ttggattcat gagaggtgtt     1260

aggtccttta aaaaacatgg tagataaaga gttgacacta actgggtcct tttgggaaga     1320

gagaagcatt tcctcataaa gactttaaat tgctaggacg agaatggcca acaggagtga     1380

aggattcata atctttatct ttacttagat gtaaagaaca attactgatg ttcaacatga     1440

ctacgtacat aaaggcgcat ggagaaaagt attggccttc catgcattag gtagtgcttg     1500

tatcaattct tatagtggct agggtatcct ggaaaatctt acgtgtggat catttctcag     1560

gacagtctag gacactaacg cagtttctca tgtttggctt ctattattaa aaaatgatac     1620

aatctcggga aaattttttt gattttcatg aaattcatgt gtttttctat aggtaacaca     1680

aattctgact gctatgatat gcctttgttt tggaacagtt gtctgctctg tacttgatat     1740

ttcacacatt gagggagaca ttttttcatc atttaaagca ggttatccat tctggggagc     1800

catatttgtg agtatatatc tataattgtt tctgaaataa cactgaacat aggtttttct     1860

ctttctcaga tctaaccagt tgtttattcc cagtattaac atgatattta taattcttaa     1920

ttataaatta tatgtgagca tatataacat agatatgctc attaacaaca acaaaagatt     1980

ctttttacaa ttaacggtgg gttaaacatt tagcccacag ttttatccca tgagaaacct     2040

gaatctaata caagttaaat gacttgccta agggccactt gactaatagt aattgaacct     2100

aaactttcag aatccaactc caggaacata cttctagcac tattcatcaa taaagttata     2160

tgataaatac atacaacttt atctgtcaac taaaaataac aacaaaggct gggcatggtg     2220

gctcacaccc gtaatcccag cactttggga ggctgaggca ggtggatcac ctgaggtcag     2280

gagtttgaga ccagcctgac caacatggtg aaacctcatc tctactaaat ataaaaaatt     2340

agctgagtgt gatagtgcat gcctgtaatc ccagctactt aagaggctga ggcaggaggc     2400

ttgtttgaac ctggaaggca gaggttgcag tgagctgaga ttgtgccatt gcactccagc     2460

ctgggcaata agagcgaaac tctgtctcaa aataataata ataataatag aaaataaagt     2520

tgtcttcatg aaaaatgagg aaagagattg ctggggtgag aaacattaag atcaaagggc     2580

atatggtgac cttctatgcc ctagaaactc ttttaggtat tttctcctgg tatctctttt     2640

actcatcgtt ctatctggaa aaataggtgg atgagtgaga taataaggta tataactttt     2700

taaaggtcta attgacatat aataaattgc aagtatttca gatgtacaat ttgctaacct     2760

tgacacacat agacacacat gaaaacatca ccacattaat acaatgtatg tatccatcat     2820

ttccaaaagc ttccctgtgt atctttgtaa ctctttcttc ctccctccac tccttgtcct     2880

ctcgttccca agaaaacatt gatctgcttt ctgtgaatat aaattaactt acatttttta     2940

gagctttata taagtatgtt ctctttactg tttgtcttcc ttcgctgcac agttattttg     3000

agattcttca agttttttct ttatatcgat acttcattca caagaatata ttttaattct     3060

agactatgtc acattgactt tgtagtctgc taaatcctta gtgctcagat gacttgttca     3120

ggactctcct tgaacctgta cctctgttat aattgaaact tgtctctact gtctttttat     3180

ttcaaacaca gcttatgagg tgtctctcaa cccatcaaac tcacaatctg agtctttagg     3240

agattgcttt gaatttgtgc tattgactta tatttatatc aaatatgtaa atgtttggta     3300

aaaatatcat catgtacatt ttcataatta ctctatattc acatgatata tgtcagactc     3360

tggaaatatg catgccacag acacgtgttt cttgcctaaa ggggctgatg gaagacgcac     3420

atacaaatag acgattgcaa tagaatgaga gtggtggtct aatcgattca tgccctgatg     3480

ttgctggacg ttgctactcc aagagtaacc cctgcattgt cagggttagc atctcctgga     3540

agcctcatgt aaatgaagaa tttcatgctc catccaggac ctaatgaata agaatctgca     3600

ttttagcaag accctcatat gattcatata cacttttttt tttttttttt agatggagtc     3660

tcactcttgt cgcccaggct ggagtgcaat ggcatgatct tggctcactg caacctctgc     3720

ctcccgggtt caagtgattc tcctgtctca gcctccctag tagctgggac tacaggtgca     3780

tgccacagtg gctggctaat ttttgtattt ttagtagaga cagggtttca ccattttggt     3840

caggctggtc ttgaactcat gacctccggt gattcccccg cctcggcttc ccaaagtgct     3900

gggattacag acatgagcca ccacacccag ccttattcgt atacacattt aattctgaga     3960

agcactctat agaaaataag aataagaaaa tattgggctc acaggtgaca ttaataagta     4020

actttatcga gtaccccaaa tgttacctat gtttggaaga tggggttaaa aaggacacat     4080

tgaaaacaag aaactcattg tggctttttt ttcctccttt ttgaacagtt ttctatttct     4140

ggaatgttgt caattatatc tgaaaggaga aatgcaacat atctggtgag ttgcccgttt     4200

ctgtctttgt ccatccttga aaagataaga agaacagagt tttaagagtc ttaagggaaa     4260

cacatctttg tctcctatat tacttgtgaa tgtggatata tgattttgtt tcaatctatt     4320

ttgtgtccta aggctttttg caacagaagt tggatataat cattagaaac ataaattgta     4380

ccatttaaca tacaatgaag tttatgttta ccttgacgtt tcttctaaaa aaagtgtcct     4440

cacaccggca ttgtccttgt aggcatattc acatgatcaa ataaataatt agttttcaat     4500

taaggagaat atttgaggaa agaccgtacg tgttcatgtg gttcctgaag gcagtccagt     4560

gagaaagtaa tatatgctca ttaaacaatg cggacatttt cagggtttcc ctttttaacc     4620

aaaatttgga agcaatgtgg aatttactgg atgcatccag ccctgaaatg aagataggtt     4680

tattgaatgt gccagcaagt gcaggcccag gtctgagtgt tcttcattat tatcaggtga     4740

gaggaagcct gggagcaaac actgccagca gcatagctgg gggaacggga attaccatcc     4800

tgatcatcaa cctgaagaag agcttggcct atatccacat ccacagttgc cagaaatttt     4860

ttgagaccaa gtgctttatg gcttcctttt ccactgtatg tatttttttt tgtgtgggaa     4920

gactaagatt ctgggtccta atgtaagtaa gaagccctct tctcctgttc catgaacacc     4980

atccttttct gtaacttcta ttacacagta tagtggttct gtaagttcac acagcccagg     5040

gagatgctgg ctgcccactc ccctcaaccc aggcaaattc ctcggggtta aagttatcta     5100

ctgcaagtga cgatctctgg gtttttctgt gcctgtgttt gtgtgtgtgt gtgtgtgtgt     5160

gtgtgtgtgt gtgtatgtgt cactttaaaa ggactggtca gatggtaggg agatgaaaac     5220

aggagatgct ataagaaaat aaacttttgg ggcgaatacc atgtgactct ttttgtttgt     5280

catttgttgc tgttcaatag gaaattgtag tgatgatgct gtttctcacc attctgggac     5340

ttggtagtgc tgtgtcactc acaatctgtg gagctgggga agaactcaaa ggaaacaagg     5400

tagatagaag cccgatataa aatcttgaat gacaggttaa cgaattggag ctttattcct     5460

taaaaatatg gcctgggttt tctgaaacat ttcttccaga aaatagtttc tccaagtttt     5520

attactttgg tttacaaatc tcacatttta aatcacattt tatacccata agtagcacac     5580

atttcataat atatccctct gaatgagggt tgggataata ggatctgtat aatgttagaa     5640

aatgccttaa agtgtgtgga gcatgagaga tggatgtgca gaaggcttgt gaggaaacca     5700

cccaggtatc tggccttgtt ttctgcccca gaagtagccg cctattcctg tttctgtttt     5760

attcctttgt ttcttgactt ttcctttcca acttgctcta aaacctcagt tttctttcct     5820

ttctgattca tgactaccaa atgtttccac ttgcctcacc cgtccattac acctttgata     5880

agaaccacca gcaccttgtg ctcatgtact tgcccatgtc tgatggaaga aacatactct     5940

ctccatctgt ccactttcct gaggcattca agtctagcca ccttttaaaa tcactctcct     6000

ccaggctggg cacggtggct cacgcctgta atctcagcac tttgtgaggc tgaggagggc     6060

ggatcacttg aagtcaggag ttcaaaacca gcctggccaa atggcaaaac caaatcttca     6120

attaaaacca aatcttaaac caaatctcta ctaaaaaata caacaaaaca aaacaacaac     6180

aacaaaaaca gaaaaggaaa cattagccca gcgtggtggc aggtacctga ggttccagat     6240

acttgggagg ctgaagcagg agaatcgctt gagcccaaga gatggaggtt gcagtgagcc     6300

gagatcatgc cactgcacca cagccagggt gacagagcca tacttcccag cacattggga     6360

ggccaaagct gaagaataat ttgaggtgag gatttggaga ccagcctggc caacatggtg     6420

aaactccgtc tgtactaaaa atataaaact tagtggggca tgggggcaca cacctgtaat     6480

ttcagctact taggaggctg aggcaggaga attgcttgaa cccgggaggc ggaagttgca     6540

gtgagccaag atcgtggcca ctgcactcca gcctgggtga catagtgaga ttctgtctca     6600

aaaaaaataa aagaaattta aaaaatcact ctcttccaaa gatagataaa taagacagca     6660

gatatactaa ggaataacct caccaacttg tcattgactg acatgatttc ttttgggccc     6720

acttggccag ctagtctggt ttggttttct ggaaatgaaa gaaataatca gagtttaatg     6780

acagagagcg tgagacccag aaagacaaaa gtagatgagg taagtctctt gagcgagact     6840

tctagggatg ggaaatttgt ggtgattgat atgaaatgat ttttccctta tcaggttcca     6900

gaggatcgtg tttatgaaga attaaacata tattcagcta cttacagtga gttggaagac     6960

ccaggggaaa tgtctcctcc cattgattta taagaatcac gtgtccagaa cactctgatt     7020

cacagccaag gatccagaag gccaaggtct tgttaagggg ctactggaaa aatttctatt     7080

ctctccacag cctgctggtt ttacattaga tttattcgcc tgataagaat attttgtttc     7140

tgctgcttct gtccacctta atattctcct tctatttgta gatatgatag actcctattt     7200

ttcttgtttt atattatgac cacacacatc tctgctggaa agtcaacatg tagtaagcaa     7260

gatttaactg tttgattata actgtgcaaa tacagaaaaa aagaaggctg gctgaaagtt     7320

gagttaaact ttgacagttt gataatattt ggttcttagg gttttttttt ttttttagca     7380

ttcttaatag ttacagttgg gcatgatttg taccatccac ccatacccac acagtcacag     7440

tcacacacac atatgtatta cttacactat atataacttc ctatgcaaat attttaccac     7500

cagtcaataa tacatttttg ccaagacatg aagttttata aagatctgta taattgcctg     7560

aatcaccagc acattcactg acatgatatt atttgcagat tgacaagtag gaagtgggga     7620

attttattaa gttactcgtt gtctggggag gtaaataggt taaaaacagg gaaattataa     7680

gtgcagagat taacatttca caaatgttta gtgaaacatt tgtgaaaaaa gaagactaaa     7740

ttaagacctg agctgaaata aagtgagtgg aaatggaaat aatggttata tctaaaacat     7800

gtagaaaaag agtaactggt agattttgtt aacaaattaa agaataaagt tagacaagca     7860

actggttgac taatacatta agcgtttgag tctaagatga aaggagaaca ctggttatgt     7920

tgatagaatg ataaaaaggg tcgggcgcgg aggctcacgc ctgtaatccc agccctttgg     7980

gaggccgagg tgggcagatc acgaagtcag tagtttgaga ccagcctggc caacatagtg     8040

aaaccccgtc tctactaaaa atacaaaaaa aaaattagct gggtgtggtg gcagtcacct     8100

gtagtcccag ctacttggga ggctgaggca ggagaatcgc ttcaacctgg gaggcggagg     8160

ttgcagtgag ccgagatcgc accagtgcac tccagccttg gtgacaatgg gagactccat     8220

ctcaaaaaaa aaaaaaaaaa aaaaaaagat aaaaagtcag aaatctgaaa agtggaggaa     8280

gagtacaaat agacctaaat taagctcatt tttaggcttt gattttgggg agacaaaggg     8340

aaatgcagcc atagagggcc tgatgacatc caatacagag ttctggtaaa gataaaattt     8400

gatacaggtt tggtgtcatt ataagagaaa tcattattaa atgaagcaag ttaacactct     8460

aagagaatta ttttgagata gaagtgaagc taagctaaac ttcacatgcc tataattgga     8520

gggaaaaact aaggataaaa tctagcctag aagatacaat aattagtcat aaacatgcat     8580

tgtgaaactg tagagagcag gtagcccaaa atagagaaag attagataaa gagaaaataa     8640

gtatccatca gagacagtat ctctaggctt gggcaagaga aaagtccaca gtgataagca     8700

actccaccta aggcatgaat atgcggcaga gaaaacagca atagtgaatg aatgcaaaag     8760

gtgctgagaa attccacaca tgagtattgt gatgagtaaa tgaataaaac atttgcaaag     8820

acctttagag aaagagaatg ggagcatatg tgagaaataa gatagttgat tatgaataga     8880

aggtagtgaa gaaaagcaag ctaagaaaaa attctgttta taaaagaagg aaaagatagt     8940

ttatgttttt agcctaagta taagagtcct acagatggac tgaaaaaaat cagtctgaga     9000

gtattagtca caattaatga aataattaca ttttatgtat tgaggatgcc aagattaaaa     9060

ggtgacaggt agatgttaat ttccctagat tgtgaaagtg atcacgacaa tcacacaaca     9120

aataattaag tgacttggta tgctttattt aattgtaggg cctgaggttt tccattctca     9180

tttttctaaa atacaatttt gtttctccaa atttgacagc agaataaaaa ccctaccctt     9240

tcactgtgta tcatgctaag ctgcatctct actcttgatc atctgtaggt attaatcaca     9300

tcacttccat ggcatggatg ttcacataca gactcttaac cctggtttac caggacctct     9360

aggagtggat ccaatctata tctttacagt tgtatagtat atgatatctc ttttatttca     9420

ctcaatttat attttcatca ttgactacat atttcttata cacaacacac aatttatgaa     9480

ttttttctca agatcattct gagagttgcc ccaccctacc tgccttttat agtatgccca     9540

cctcaggcag acacagagca caatgctggg gttctcttca cactatcact gccccaaatt     9600

gtctttctaa atttcaactt caatgtcatc ttctccatga agaccactga atgaacacct     9660

tttcatccag ccttaatttc ttgctccata actactctat cccacgatgc agtattgtat     9720

cattaattat tagtgtgctt gtgacctcct tatgtattct caattacctg tatttgtgca     9780

ataaattgga ataatgtaac ttga                                            9804


<210>  7
<211>  1687
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (133)..(867)

<400>  7
gttacaagtt cacaagaagg aaccaaggat cagcctgaga gaacccagag ttaaggctct       60

tcgggttcct gagagctcgg ctggaagtga ctgggtgaca aggcacacag gctcagccgt      120

gggagctcaa tc atg att cca caa gta gtg acc agt gag act gtg gca atg      171
              Met Ile Pro Gln Val Val Thr Ser Glu Thr Val Ala Met         
              1               5                   10                      

att tcg cca aat gga atg agt ctt ccc caa aca gac aaa ccc cag cct        219
Ile Ser Pro Asn Gly Met Ser Leu Pro Gln Thr Asp Lys Pro Gln Pro           
    15                  20                  25                            

ttc cac cag tgg caa gac agc ctg aag aaa cat cta aag gct gag atc        267
Phe His Gln Trp Gln Asp Ser Leu Lys Lys His Leu Lys Ala Glu Ile           
30                  35                  40                  45            

aaa gtg atg gcg gca atc cag atc atg tgt gct gtg atg gtg ttg agt        315
Lys Val Met Ala Ala Ile Gln Ile Met Cys Ala Val Met Val Leu Ser           
                50                  55                  60                

ctg gga atc att ttg gca tct gtt ccc tcc aat cta cac ttt acc tca        363
Leu Gly Ile Ile Leu Ala Ser Val Pro Ser Asn Leu His Phe Thr Ser           
            65                  70                  75                    

gtg ttt tca gtc ctg tta aaa tct ggc tac cca ttt ata gga gct ttg        411
Val Phe Ser Val Leu Leu Lys Ser Gly Tyr Pro Phe Ile Gly Ala Leu           
        80                  85                  90                        

ttt ttt ata gtc tct gga att ctg tcc atc gtc acg gag aca aag tca        459
Phe Phe Ile Val Ser Gly Ile Leu Ser Ile Val Thr Glu Thr Lys Ser           
    95                  100                 105                           

aca aaa att ttg gta gac agc agc ctg act ctg aat atc ctg agt gtt        507
Thr Lys Ile Leu Val Asp Ser Ser Leu Thr Leu Asn Ile Leu Ser Val           
110                 115                 120                 125           

tca ttt gct ttc atg ggc atc att atc atc tct gtc agc ctg gct ggt        555
Ser Phe Ala Phe Met Gly Ile Ile Ile Ile Ser Val Ser Leu Ala Gly           
                130                 135                 140               

ttg cat cct gcc tca gag cag tgc ttg cag agc aag gag ctt aga cca        603
Leu His Pro Ala Ser Glu Gln Cys Leu Gln Ser Lys Glu Leu Arg Pro           
            145                 150                 155                   

act gaa tat cat tac tac caa ttc ttg gac agg aac gag tgc ttt gcc        651
Thr Glu Tyr His Tyr Tyr Gln Phe Leu Asp Arg Asn Glu Cys Phe Ala           
        160                 165                 170                       

gcc aag tct gtt ctg gct gga gtc ttt tca ctg atg ctg atc agt act        699
Ala Lys Ser Val Leu Ala Gly Val Phe Ser Leu Met Leu Ile Ser Thr           
    175                 180                 185                           

atg ttg gaa ctt ggc ctg gct gtc ctc act gcc atg ctg tgg tgg aaa        747
Met Leu Glu Leu Gly Leu Ala Val Leu Thr Ala Met Leu Trp Trp Lys           
190                 195                 200                 205           

cag agt cac tct aac atc cct ggg aat gtt atg ttc ctg cca cat agc        795
Gln Ser His Ser Asn Ile Pro Gly Asn Val Met Phe Leu Pro His Ser           
                210                 215                 220               

tca aat aat gac tcc aac atg gaa tca aag gta ctt tgt aac ccc tca        843
Ser Asn Asn Asp Ser Asn Met Glu Ser Lys Val Leu Cys Asn Pro Ser           
            225                 230                 235                   

tat gag gaa caa ttg gtt tgt taa gaaaaacaaa acaaaacaaa actaaatacc       897
Tyr Glu Glu Gln Leu Val Cys                                               
        240                                                               

acaaaaacaa atggaactat accgcagaag atatgtcttc atgataatgc agaaattcca      957

accatcacag ggtagcaatg cttgctactt aaaatgtaga ctgttcatac agtgggtacc     1017

agtatgagtt gaatgtgtgt attactggca ccctattgat tttcatgacc ttggcttcag     1077

ccaaagccca gacctacaaa tggtggcctt tcttagaaaa ccaaacagaa tgtttcaggc     1137

cattgtagtg gggaaaaggg acaacatttt cttgccccct gcaattaaca gcaacagtta     1197

accattagca gtctttgtat tcagaatctc tgctatgacg tgggtcttct atcatatcag     1257

ttttattcac tggtgtgaat aaacaaggga cctgcaatga agtctgaaga agtttccatg     1317

ttgttggttc aaaataaagt ctttttgtga ttgtatattc tttttgtatg gggttttgtg     1377

tgggttttgt tgttgttgtt gttttgcttt tatgcacaga tcaagtcctc agtggtacat     1437

aaacacatgt gtttgctatt ttttttttgt tctctatcaa ccaaaaaaaa aaaaaaaaaa     1497

ggcatgggaa agagaaaaag gaatatatct gtgtctctgt gtttatgtgg tgtgtgtgtg     1557

tgtgtgtttt aaactaaaac tgaatgaaca ttcaaagttt agcaatgtat tttggaggta     1617

ccagataaca tacttatttc tagaatcgcc agagcaaatg agagacattt tgtcgcttct     1677

tataagaggc                                                            1687


<210>  8
<211>  244
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ile Pro Gln Val Val Thr Ser Glu Thr Val Ala Met Ile Ser Pro 
1               5                   10                  15      


Asn Gly Met Ser Leu Pro Gln Thr Asp Lys Pro Gln Pro Phe His Gln 
            20                  25                  30          


Trp Gln Asp Ser Leu Lys Lys His Leu Lys Ala Glu Ile Lys Val Met 
        35                  40                  45              


Ala Ala Ile Gln Ile Met Cys Ala Val Met Val Leu Ser Leu Gly Ile 
    50                  55                  60                  


Ile Leu Ala Ser Val Pro Ser Asn Leu His Phe Thr Ser Val Phe Ser 
65                  70                  75                  80  


Val Leu Leu Lys Ser Gly Tyr Pro Phe Ile Gly Ala Leu Phe Phe Ile 
                85                  90                  95      


Val Ser Gly Ile Leu Ser Ile Val Thr Glu Thr Lys Ser Thr Lys Ile 
            100                 105                 110         


Leu Val Asp Ser Ser Leu Thr Leu Asn Ile Leu Ser Val Ser Phe Ala 
        115                 120                 125             


Phe Met Gly Ile Ile Ile Ile Ser Val Ser Leu Ala Gly Leu His Pro 
    130                 135                 140                 


Ala Ser Glu Gln Cys Leu Gln Ser Lys Glu Leu Arg Pro Thr Glu Tyr 
145                 150                 155                 160 


His Tyr Tyr Gln Phe Leu Asp Arg Asn Glu Cys Phe Ala Ala Lys Ser 
                165                 170                 175     


Val Leu Ala Gly Val Phe Ser Leu Met Leu Ile Ser Thr Met Leu Glu 
            180                 185                 190         


Leu Gly Leu Ala Val Leu Thr Ala Met Leu Trp Trp Lys Gln Ser His 
        195                 200                 205             


Ser Asn Ile Pro Gly Asn Val Met Phe Leu Pro His Ser Ser Asn Asn 
    210                 215                 220                 


Asp Ser Asn Met Glu Ser Lys Val Leu Cys Asn Pro Ser Tyr Glu Glu 
225                 230                 235                 240 


Gln Leu Val Cys 
                


<210>  9
<211>  11845
<212>  DNA
<213>  Mus musculus

<400>  9
gttacaagtt cacaagaagg aaccaaggat cagcctgaga gaacccagag ttaaggctct       60

tcgggttcct gagagctcgg ctggaagtga ctgggtgaca aggcacacag gctcaggtag      120

gcaaccctga agggacttcc ctctgtgtag cactctgttt ctgggactga gttacaagaa      180

cttgctgatg ctcatgaaag caatggagac acgggggctc tttagaatta aatgggcaaa      240

ggcacagggc atctggctta cctctgtcct ggccatttta gctgcataat cttggtgatc      300

actgacataa ggagcagaac tctcaggtca ttcactgatt aggcagccta agggctgaga      360

atagcacaga gaacagaagg gagccaagat gagctcagaa accgattccc cagggaacat      420

ggtccttcca cctaacaagg gcatgattgt cagtatcatg acaaaacttg aaaaaagctt      480

aggactccag gacttctcat atgggtgcat tcagctgctt cttcacactg aagagactta      540

aacacaggct gcccctggca ggtgggaaaa taaggagaga accagagtca gagacagctg      600

tgccgccaca cacaactgtg tgtaggcaac tggtcagtaa tgagaacttt gcctgtttat      660

ttagcattta tttgatgttg ctgtgcaaag catcattact tcctcatata catcaaagtt      720

ttgattctga atttgttact gattgtgatt ttattaatta atgtaaagga ttgttttcaa      780

gaataaaaac actagattat gtctactaaa atatgataaa atgtgaggtg ctaatcctaa      840

aattggcact attagacaca cgaaacagat gcatagggtt gcacgttttg agtggtacat      900

agcatggatt ggaaagcact gaaggctgac tttagtacct catggatagc aaagcagccg      960

gacagtgcaa gtcattgaat aaagacaatg cacttgttct aggtgaaatt gggaaagagc     1020

cagagctaca tctgacaaat tttgtgtaaa catttgggca tagaaacaga aacctgtggg     1080

gatccaggat ttcccttcct atgaggtgtt tattatctaa aatcattgtg gtgtgtttaa     1140

cattttgaaa aaaataactc ctaaatctga gatgtgatgg ttttacattt ctctgtacca     1200

gcagtttctt ctgccaaagg acaggtcaag gatgcccaaa ggtgcacagt ctgggaggtg     1260

ggggcagaac tgggaagcat ggtttgtttt gtttgttgtt attttatgtt caaagccaag     1320

gcacttaatg acttactgaa aattcatgtg ctgtgtactc tgatcatgct tttccttccc     1380

atttcttttc ctagatcctc tcaaactatc caacactatc caactttgca tcttctctct     1440

ctctctctgt ctctgtctct gtctctgtct ctctgtctct ctctctctgt ctctgtctga     1500

ctctctctgt cactgtctct ctgtctctgt ctctgtctct gtctctgtct ctctgtctct     1560

ctgtctctgt ctctgtctct ctgtctctct gtctctctct gtctctctct gtctctgtct     1620

ctctctctca cacacacaca ttagcaaaaa caacaaaaaa ggagaatgaa atgtaaatca     1680

accaagcaaa cagaaccaaa actaaaccaa accactacaa tgggcacagt attttatcac     1740

acctgagtcc attttctctt ccagccgtgg gagctcaatc atgattccac aagtagtgac     1800

cagtgagact gtggcaatga tttcgccaaa tggaatgagt cttccccaaa cagacaaacc     1860

ccagcctttc caccagtggc aagacagcct gaagaaacat ctaaaggctg agatcaaagt     1920

gatggcggta aatcccactc agaacatcct ggggtgggta gagggcagag ggtgaggctc     1980

tatgtattag gaccagagat aaatttgggt ggggggagcc ttcagttttg acagaatgat     2040

cacagagtgg ccagtacatt ggtggaagcc ccatggcaag ctgcttacat cactaaaacc     2100

ttctaaaatt ggcaaataat tccgtttatt atgatgaact tggactacac ttcaatgacc     2160

ttattccatg tgtcattgag attttgttgt ttagttctct ttttttttct tttcattttt     2220

gaagcgtacc ttactaagtt attttattgg tgaaaatatt tgtagctaca ttctaggtgc     2280

tctctgagtg taaaaagctc ttctcctcct tagtgaaaag agacggtaca gaaagaccat     2340

tggttctcta ctctgtgttc attctagaat cacaaatgca actattttgg gtaaagggag     2400

aagaaaaaca tttgctgtga gttgtttttc agtcttgtct gtactagcgc tatatgcatg     2460

ggtctctgtt acccagtctc agaacttaat ggaactgatg gcctcgtatt gggcatacat     2520

acaagccact ggattccttt gaagtacatg tagcaaaaag tttataagat ttcttaatac     2580

aaaattccaa gacctgtgag tctgagaggt gaaggaaggc atcaggaaga caaaattgcc     2640

cttttaatat ggaagcaagg gatcccaaga atgaacaacg ggactgaagg tcctgtggag     2700

cttgacagag acagtggacc tatgtagtag tctgtgggtt ctgaatgatg tgtggagagg     2760

tttccacatt ctagtgctca gagtgggaag ggtttcagat gcctgttttt cccacaatag     2820

ggagcagaga cttgttaccc atgcactcac gttcagccca gcctggagat gccagaaagg     2880

gtcatgagca tgcaatgggt tcaaggacag aaacgcctaa aggtgacccg aggctctagc     2940

agaactacat ccccaccaga atgagctttc ctctctcact gcagagcttg tacagtgtct     3000

gtgtgctcac tgggatgttt gtagaagatg acaatgcacg ggcaccatgg gaaaagtgga     3060

gaggtccttc ttgtcattgc tggtttaatc accatttccc ttctttcaac aggcaatcca     3120

gatcatgtgt gctgtgatgg tgttgagtct gggaatcatt ttggcatctg ttccctccaa     3180

tctacacttt acctcagtgt tttcagtcct gttaaaatct ggctacccat ttataggagc     3240

tttgtttgta agtagacttc tgtggggaat aagatgggga ggagagagaa gggagttttc     3300

acctagctgc attcctgtat actgtgaaaa aaaggtcaat ggtaaacctt gttctcatgt     3360

ctgtcatcag aggtcttagt tatatcatcc tgaagatttt tacatctaat ccatttctta     3420

taaatttcac cctatcatgt catctattga gcgatgatga ctttggtggc cacttgagtt     3480

tagggaaaag tctaggaagt ggcactcaaa tgatctagag ctttctgtat cgtgcaagtt     3540

cactcggtgg accccactgc aggaaagaac actttcattc ttttgatctg gctttttgga     3600

ggcattccgg gtgatagact agatattcct ctgagcctgc tccatgtctg gggtgaggag     3660

gtcatgaagg tccttttctc agaggaccgc tcttctctag acagatgtgg atgagtcccc     3720

cacacaagtg aggattcctc tcactggggc ttccaatctg cttagtacag ttttccccct     3780

tcctacattt cttcctttga ttcatccaca gctcaatctt tccttctctt gtgtcagtga     3840

tttctgattt tcatttctct gaccaatgta ttgtctgatt tcaccagatt tccatgattg     3900

ttctttgtcc cagtttccat tcaaagacac tgcattccac cacttctgtc tccagagtct     3960

ccactaagat gtccttatcc gaaccttctc agacttccct tgtccttgat gactttgact     4020

ttttcagatt tatgctggcc tagatttttg taaatattta tgttcgagtt tgtctgatat     4080

tctgttaatc tttaatggag tagagagtgg tgactgtgtg ggtgacaatg acatcagtga     4140

catgccatac tgtaggtagc atgaagggtg catattatct acaacatgtc actgttgaca     4200

taaccctgat gtggtgatgt ctaggtcagt gctgtttctt tatatttctc tcctcaccat     4260

tgtgtgctct ttccattgag catctcttgc attagaagag acactcagtt cttttaactt     4320

tattagactc tatctctgaa actgtgggca tagctcagca gcaaacacat ccatagactt     4380

cacagaccct gaggttaatc cctattattg caaaggtaaa gatccagcat ttgtttatat     4440

ggacaggctg cttgacttta gagaatagaa atcacaagtt ttctacttga aaagaaaatc     4500

ctaaatgatt tgttacttgg tttcatttca tttcttggat aatagatcat gataaatcat     4560

gatttaaaat aatcagaact aaaggcttct ggaaatgaaa ccttatagtt cctttctctt     4620

gatctttaga accagttact gaaagtcctc tttcttttta tatgtgtttg ttaatatctt     4680

cccttatttc cttaaggaaa caaaaaacaa aaacctattg tagagcactc tcaaactttt     4740

accaaaatct gaaaggggta ctttcctaaa ctcatttttg gatgccagca ttatgttgat     4800

gccaaaatag tgatgtaatg ctggccagga acatgacagg aaatgaaaag tgcaggccaa     4860

tgtcttagag gatgtagctc ccaaattcct cactaaaata ccagcatgct ggaaattgca     4920

tatttaaaat tacctcaata tgttcaagtg agatttactg aaagaagttt gcatggtttt     4980

tatattcaaa tcagagtccc attactttat tgatgaaagg agagacaacc ctgaaaacta     5040

ttttttattc tctctccttg taggtcaaag catagactct aaaataatct aaatccatat     5100

tttcccttgc aattaacaaa acatcctttt gctatccctt aaagtgctta tgaattttga     5160

tgggataaat ttctgctctt ttcttttact tttctgaata gtgcatggac aaaaagacac     5220

acttgtgagc ctaagtttgt ggatcattgg tcatttggtc cgtgagagtt tgtcataaac     5280

accgtagagt aaactgtagt cactttgtac atagaaattg aactgccaat gttttcttct     5340

tgtctgagca gtttatagtc tctggaattc tgtccatcgt cacggagaca aagtcaacaa     5400

aaattttggt gagtacaaga gtcatatccc agaactaatg agcacaaaac ctcagggctg     5460

ggcttttaat ctctacagtg attacttctt caatttgtga gctgattctg ggttctccat     5520

ttccctacat ggaacacact ctttctgtca tggtgatgaa aatcatagtg tgcctgatgt     5580

ctgagaccag tgccaagaaa tctcatgtcc tgctctctta tgatgccatt gtgtaggcag     5640

caggcaacga tggttatttt gatcatctaa gtgactggat tgagaagcac ctaaaagact     5700

aataaaaaat acctctgggg gtgttctagt tctaaactgt gattgctcca ttcactaata     5760

taaagactac gatggaataa aagggagaaa ttgaactgtg gttagcatag gtatcctctc     5820

actgggcttc ccgaccatca tgttgtgagc tgttctgctc tgccacccaa gtcccacaat     5880

ggtcagctga gcctctgaaa ctgagccaac atatttttat cttgagttgt ttatgtgagg     5940

cactttgtca tggcaaggaa aagtctaaca acacaaattt tactcttcag tactaaagct     6000

attgtcctta tttttaaaga gttttattta ttgtggatat actatgcaat ctcaccattt     6060

aaaagtcata tgaatcccta gagaaaacat tcatgttttt cctctatatc tccataaagg     6120

aaaggctttt gctgtgttgg ctatacaatt tgaactggga agcagaatgc tggaattctg     6180

aaactctcag taactatttg ttttagctaa gaattcagct ttcgtacttt atttccttcc     6240

agtgaaaaac tagtcttgga cagaaaaaag ctggactata gaaagaagtt ttgaacaatg     6300

taaagattca cctagtcttc agtcacacat tcctcaagag ttgattcaga aagtcattgg     6360

agagaatgcc atgtaatgca atagcttagg gatttagtta tgaagagctg actaacctag     6420

tctcccaaat atatagaatg ttaattactt tcctgatgct gtaataaaaa aaataccatg     6480

actaaaagca attaaacata taagtagtct gcaagtagat taaggctcat gactgatgct     6540

tcacaaatgc tgaagaatgt tcttttcata caagtgtaga gagactaaag aagactccca     6600

gttaggatga acctagtgta ttccaagagc acacatacta tcagtatcca gattgcaaat     6660

attgttcaag gtgtccaaga gtttgatttt agtcactatt tgtgaaaaga agcatcgaaa     6720

agcaccaagt tctgagtgat ttacacaatc tctctaaaat ataagtgacc taaaattaaa     6780

tcaaactcaa gtgccataca gctctgtgtg ccctaaatat acctacctgt aactgtagct     6840

ttcagactga tcttagctca attttcattt tctatacatt gaaaaagaaa gaaagccact     6900

atcaagaaat tttctttgct tcactgacac cataagtgtt atggagaaga gatccaaagt     6960

gagcattaga actgagtgat gccgatcagt gagactccaa ggacctctgg ccctgtagcc     7020

tcaatttacc aacatctagt cccattctgt ttctttctgc ctcacactgt ttccacacat     7080

aacatcctta gtcacgtatc tagatttctg tctacagccc tagttatagt caatcattag     7140

gatttccaga atacaaggtc tacctgacac tgagaacaaa ttcctcacac tcacctttgt     7200

gtatatgagc gtttgagaga ggtagaatgt aaggactgcc tcaccagcct tttctgtgtg     7260

attgaggttt ggaaaggatg tgttattcta aataaattgg ccagtattag atgtgtccat     7320

actcaactgt tgaaataact caactcaaaa gaaggaatgg ttcattttgg ctcatatttc     7380

agaggcttag cagtgtatca ttttggtgaa tctatttgtt ttgagcttgt agacaggcaa     7440

taagtggctt atgctaaaaa agcaaagatg tgtgccatgt ggcagcaagg gagaaaaaag     7500

agagtaagat gaaggtttta tgttctgata tatccccttc ctgggctttt ctctgaagac     7560

aaacctttga ttaaaaggta tttccttttt aatcaagagg catttctgac acaaattatc     7620

tacctgagga tcaggtcttt aataattgag gttcaggtga tgtcaagttc acactacagc     7680

aatgagaatg ttgaaggaca gaaacatggc taatgcctgt acctgttcct cttttcacac     7740

tctctagaga gttttccaat tttacattag aggattccat caaaagtcat cggtgaagat     7800

tttgccaggg tagtatttta attttcacca ttgaaatcct gtttatctat cttattgtca     7860

tttaggtttg gaatgagtgt gttcctagac attcataaga cctaataaat gtggtgatgg     7920

tggttgggta gagtcaccta gcaaatatca tctgggaaat ggagtatagg gaaaatagac     7980

ctggaaaacc agggctctcc tttttcttct ggtagcaatt attcattagg aagaataaag     8040

aaataaatta ttaatctttc agctgctaat gaagccaaat aacaagaatt gctgcaccat     8100

tttggaagaa aggtataaat gaaacgtgct gcttcttcca ggtagacagc agcctgactc     8160

tgaatatcct gagtgtttca tttgctttca tgggcatcat tatcatctct gtcagcctgg     8220

ctggtttgca tcctgcctca gagcagtgct tgcagagcaa ggagcttaga ccaactgaat     8280

atcattacta ccaattcttg gacaggaacg agtgctttgc cgccaagtct gttctggctg     8340

taagtatttc taaaggctgt agtgaacgtt tttagttatg gggaaatagt actctttttc     8400

ctatcttttg aaactctgtc actctgtttg gtttgagatc ttagctgaat aaagcaaagg     8460

taaataatga tagagctttt taaccccaaa tcattttaac tttgaaatta ttctggatta     8520

aaagctttaa caccttttcc agagggccgg atatatagat tggaaagaga tgtcagagat     8580

gccgttagca caataagatt cataaccaaa agactctggt gattttgact tgccaacaag     8640

gaaaccatgc acatatgtag tagagggagt aaagtgagct gagcaagact cagctaagca     8700

ctgagaaatg gattgtgaca aggacaggag tggggcgggg gtgtcagatg tctgctccct     8760

caagtgctca cagtagccag cactgggctg tgtggataca acctcactgt tgcttccatc     8820

atccgcaaag agatgggatt gttaaaagag aaaagaaata cagcgaggtg gagaagagta     8880

gaactggcag tgatgtgagg gactgccatc ttgttggaag aaagcaatgc aatttgacta     8940

acaggaataa catgccttca attacaacat ctaagaacat acacgtggtc cgcatcacat     9000

ggagcgaaca ttgggtaaga taacaatgaa gatcctgcat tatattaatt ctcttatgac     9060

aataaaagta aaataagaaa aaccacagct ccaaaatggt gagatagttg ggtctggtca     9120

acctcaggct ttctgtttcc ttatggatct gggtccagtg tttcttcctt agttaagaaa     9180

accacaagaa gaaaaagtgt gtgtaaatta gatgcataat aatgtgagta aagtaacatt     9240

tggaataact aagcctgact ttagaagctt gaagcattgg ggagaaattc gcatgaatca     9300

caaagtaaga tgacatcatg ggatagtttc acattgtatg tagtttcact gcttgtgtgg     9360

ggggggataa atgaagagct tacaatgtca cattcatcat ccttcccatc aagtggtttt     9420

catgaaggac acctccggac aaaggctatg ggatatgtgt tctttactta gacccttctt     9480

ggagctgatt tgtgatgtct cggactgtaa aaactggatt gcttttctgc ctttttagca     9540

tcacaaaaag aaatgcatcc caaggaagaa ggttctatca atgctaattt ctaaaaagag     9600

cttgcagggt cagaacctca ccaaccctca ctagtctctg cagagaaaat actacacagg     9660

tgtgataaga gagcacaaag aagctggaga agcaaagatt tgctcagcct cacactaagg     9720

aactgttgac tctgtcctgg gactcctctc tgctccctca ttcattgtca gaatctgtgc     9780

ccaagaggga tgagaagtgg tcagaaatgg ctttgttgat ttagtttgtc atcttcaccc     9840

acttctgcca agcagtgaag ggatcaggac atcaatttta gcccatttgt agttttggga     9900

agatcctttc ccttctctga tggtggagat ggtttcatct ctacagtcac ctcccaccca     9960

ggagtgaggg cttcagctga ctcagtcaca ccgacctctc ttctcctgaa tttagggagt    10020

cttttcactg atgctgatca gtactatgtt ggaacttggc ctggctgtcc tcactgccat    10080

gctgtggtgg aaacagagtc actctaacat ccctggggtg agtattctaa aggcctcctg    10140

aatcttcctg atatttctct gggacatgtt ggtctatgct gtcatgaatg gcagatagaa    10200

tgaaatcagt cacaatgaca tgaatatcag gtgatttgga cagggaggtg ggacagtagg    10260

tgatggggta gaaggtaatt gtgtagctga tgagagctat ctagacatgg aaacagacaa    10320

accatgttct tcccttccct attgcaaaca aagaaactga ggttctgaga agttaaatat    10380

atatcccgac attgtgatga atttgcctgt gtttggaatg ttcaagtgta gctgcctccc    10440

ctctaactag gaatactttc tcctacagca actagtctct ttaacaatct tgacctgata    10500

aagacaaatt gcacactgga gtgtattcag tcagcatctt aggatatgtt tttcttcctt    10560

ctgatattac tttatttctt gcataaagac actaaggaaa taatgtttgt taattgcatg    10620

caaccgttct cagccagctc gaggggtttg cttcagtaat tgaaccgaaa agctttgctc    10680

tgaccagacc tttatttaga gtgtggaaag gagaggagat gatatatata tatcaaatat    10740

atatatcaca taaggtgtgc tagtctcacc ttggaatatc tacaacattg aatgaaattc    10800

tatcatgtat atacatgtgc ctatgtatct atcttccgtc ctatatgcat aaacatatgt    10860

atgcatatat gtatatatat atatatgtat tcattcacaa tctgaaacca catattttct    10920

tttttctaga atgttatgtt cctgccacat agctcaaata atgactccaa catggaatca    10980

aaggtacttt gtaacccctc atatgaggaa caattggttt gttaagaaaa acaaaacaaa    11040

acaaaactaa ataccacaaa aacaaatgga actataccgc agaagatatg tcttcatgat    11100

aatgcagaaa ttccaaccat cacagggtag caatgcttgc tacttaaaat gtagactgtt    11160

catacagtgg gtaccagtat gagttgaatg tgtgtattac tggcacccta ttgattttca    11220

tgaccttggc ttcagccaaa gcccagacct acaaatggtg gcctttctta gaaaaccaaa    11280

cagaatgttt caggccattg tagtggggaa aagggacaac attttcttgc cccctgcaat    11340

taacagcaac agttaaccat tagcagtctt tgtattcaga atctctgcta tgacgtgggt    11400

cttctatcat atcagtttta ttcactggtg tgaataaaca agggacctgc aatgaagtct    11460

gaagaagttt ccatgttgtt ggttcaaaat aaagtctttt tgtgattgta tattcttttt    11520

gtatggggtt ttgtgtgggt tttgttgttg ttgttgtttt gcttttatgc acagatcaag    11580

tcctcagtgg tacataaaca catgtgtttg ctattttttt tttgttctct atcaaccaaa    11640

aaaaaaaaaa aaaaaggcat gggaaagaga aaaaggaata tatctgtgtc tctgtgttta    11700

tgtggtgtgt gtgtgtgtgt gttttaaact aaaactgaat gaacattcaa agtttagcaa    11760

tgtattttgg aggtaccaga taacatactt atttctagaa tcgccagagc aaatgagaga    11820

cattttgtcg cttcttataa gaggc                                          11845


<210>  10
<211>  2759
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (99)..(806)

<400>  10
ggtattcaga gccaacccat cttaactgcc catccagagc acaccgcatt tctgtgtaac       60

agtatctttc attcctggat agcccaatta atgaaaaa atg gac aca gaa aat agg      116
                                          Met Asp Thr Glu Asn Arg         
                                          1               5               

agc aga gca gat ctt gct ctc cca aat cca caa gaa tcc tcc agt gca        164
Ser Arg Ala Asp Leu Ala Leu Pro Asn Pro Gln Glu Ser Ser Ser Ala           
            10                  15                  20                    

cct gac att gaa ctc ttg gaa gca tct cct gcc aaa gca gcc cca cca        212
Pro Asp Ile Glu Leu Leu Glu Ala Ser Pro Ala Lys Ala Ala Pro Pro           
        25                  30                  35                        

aag cag aca tgg cgg aca ttt ttg aag aaa gag ttg gag ttc ctg gga        260
Lys Gln Thr Trp Arg Thr Phe Leu Lys Lys Glu Leu Glu Phe Leu Gly           
    40                  45                  50                            

gca aca caa att ctg gtt ggt ttg ata tgc ctt tgt ttt gga aca att        308
Ala Thr Gln Ile Leu Val Gly Leu Ile Cys Leu Cys Phe Gly Thr Ile           
55                  60                  65                  70            

gtc tgc tcc gta ctc tat gtt tca gac ttt gat gaa gaa gtg ctt tta        356
Val Cys Ser Val Leu Tyr Val Ser Asp Phe Asp Glu Glu Val Leu Leu           
                75                  80                  85                

ctt tat aaa cta ggc tat cca ttc tgg ggt gca gtg ctg ttt gtt ttg        404
Leu Tyr Lys Leu Gly Tyr Pro Phe Trp Gly Ala Val Leu Phe Val Leu           
            90                  95                  100                   

tct gga ttt ttg tca att atc tcc gaa aga aaa aac aca ttg tat ctg        452
Ser Gly Phe Leu Ser Ile Ile Ser Glu Arg Lys Asn Thr Leu Tyr Leu           
        105                 110                 115                       

gtg aga ggc agc ctg gga gca aac att gtc agt agc atc gct gca ggg        500
Val Arg Gly Ser Leu Gly Ala Asn Ile Val Ser Ser Ile Ala Ala Gly           
    120                 125                 130                           

acg ggg atc gcc atg ctg atc ctc aat ctg acc aat aac ttc gct tat        548
Thr Gly Ile Ala Met Leu Ile Leu Asn Leu Thr Asn Asn Phe Ala Tyr           
135                 140                 145                 150           

atg aac aac tgc aag aat gta acc gaa gac gac ggc tgc ttt gtg gct        596
Met Asn Asn Cys Lys Asn Val Thr Glu Asp Asp Gly Cys Phe Val Ala           
                155                 160                 165               

tct ttc acc aca gaa ctg gtg ttg atg atg ctg ttt ctc acc atc ctg        644
Ser Phe Thr Thr Glu Leu Val Leu Met Met Leu Phe Leu Thr Ile Leu           
            170                 175                 180                   

gcc ttt tgc agt gct gtg ttg ttc act atc tat agg att gga caa gag        692
Ala Phe Cys Ser Ala Val Leu Phe Thr Ile Tyr Arg Ile Gly Gln Glu           
        185                 190                 195                       

tta gaa agt aaa aag gtc cca gat gat cgt ctt tat gaa gaa tta aat        740
Leu Glu Ser Lys Lys Val Pro Asp Asp Arg Leu Tyr Glu Glu Leu Asn           
    200                 205                 210                           

gtg tat tca cca att tac agt gag ttg gaa gac aaa ggg gaa aca tct        788
Val Tyr Ser Pro Ile Tyr Ser Glu Leu Glu Asp Lys Gly Glu Thr Ser           
215                 220                 225                 230           

tct cca gtt gat tca taa gaatcagggg accaggacaa tctgattcaa               836
Ser Pro Val Asp Ser                                                       
                235                                                       

gtataatctt gaaagttgat ctttttacaa aattctcgca aaatttctgt ttgttccaca      896

ttctgtcagt ttttcaattg gattgttctg cagatgccac tcttttagtt atgctgtatc      956

tgatcttcta aatatctccc tttttgcgga tatcattcac tccaattttc ttgttttgtg     1016

tcacaatttc acatacatct tttctggaaa gtcatcaagg aataagttgg ctttattgta     1076

tgtctacttt catgaacaaa aggaagatat ggaagaatta ccctgagaat ttaactaacc     1136

ttagataatc aggtaatatt tggctcttag ttcattttag aattctcaac agctatagtt     1196

atatgtgata tatatccacc atatcaagcc ttctgtatgt attttaacat gatatacact     1256

tttctgtgta gatatatttc caccctcaat aataatgggg ttattttaga gacataaagc     1316

tttgtgaaaa gacgacatca tctggttgat gagtacattc acctgcacag gtatcgctca     1376

gtggtttgcc aattggtgag tagtaggcaa tagagaacat tatcaaacca ttcagtctag     1436

tgagatggat aggtacattc agggatactg tgagtatcct ttagtaagac acatgggaag     1496

aatgaagaat aaactgatga agacttgagc tagaaggtag tcaatgggaa tgacaagaaa     1556

tgattgtgta taacacatgt acgtaaatat ctaccaaaag ttggtagaga ttggcatgtt     1616

tgcctagaat ctcagcacaa ggccagcctc tgttacatag tgagttagag gccagcctgg     1676

ctatatgata tcctacatca aaggaccaaa ggagaaattg gttcaagttg ttaatacctt     1736

aaaggatagt taaacaaaca gcagtttgat atattcagtg tttgattctt taataaaact     1796

aaatgaataa cattgagggg gagggaagca gtaatgtaga agtctggatg gtggaagagt     1856

agtagagaca acttaaaact cagttttaga cttttgttct gagatgggta taagagtgat     1916

cattaaataa ggagggaaga caccaggaga attattttga gatagaacta aggcagtcaa     1976

actccacatg cctacactta gaaggggaaa gtaaggatca aaagtagaaa ccctaacaag     2036

tcaggtaagc atattacaga acattaacca gcagatgcct atagtgggga aaagttagac     2096

aaagcgaaaa taattaccca ccagagaccg tgcatgtagg cttgggaaag acaagagaaa     2156

atagcaactc caaatgaatg ctaactctga agagggtgtg ggcagaggac cagaacattt     2216

gcaaaggtgc ccagagagca gaccatgaat agaaggtagt gaggaaaaac aaacaaacaa     2276

acaaacaaac acccccaaaa cagctgagaa aatgattttg ttgctcctat taagattttt     2336

aaaagaaaca aaaagagatg ttgaaaaatc tgtttgctgg gatcagttgg tgtgttctcc     2396

atgtgtccaa gggacaggta acttttctaa atcttcatgt aaggctcgcc tcatttacat     2456

ccgtctctcc acacagccat atcctcaatt cacagttact ctatcacggt agtaaactgt     2516

gcgtgtgatc tccttatgta tcttcaggca gtgtttatcc agtaaatcag agttatttaa     2576

cttgatattt gtattagcaa atgaagttga aagaatatga gggaagtctt gaggaagaaa     2636

atcgatggtg gatatgatca tatttcactg tacacatttg taaagttctc agaaataaag     2696

aaaactcatt ttaaaaagaa ccatgtacat taaaacaatt gattaaatgg tgccaaggac     2756

aaa                                                                   2759


<210>  11
<211>  235
<212>  PRT
<213>  Mus musculus

<400>  11

Met Asp Thr Glu Asn Arg Ser Arg Ala Asp Leu Ala Leu Pro Asn Pro 
1               5                   10                  15      


Gln Glu Ser Ser Ser Ala Pro Asp Ile Glu Leu Leu Glu Ala Ser Pro 
            20                  25                  30          


Ala Lys Ala Ala Pro Pro Lys Gln Thr Trp Arg Thr Phe Leu Lys Lys 
        35                  40                  45              


Glu Leu Glu Phe Leu Gly Ala Thr Gln Ile Leu Val Gly Leu Ile Cys 
    50                  55                  60                  


Leu Cys Phe Gly Thr Ile Val Cys Ser Val Leu Tyr Val Ser Asp Phe 
65                  70                  75                  80  


Asp Glu Glu Val Leu Leu Leu Tyr Lys Leu Gly Tyr Pro Phe Trp Gly 
                85                  90                  95      


Ala Val Leu Phe Val Leu Ser Gly Phe Leu Ser Ile Ile Ser Glu Arg 
            100                 105                 110         


Lys Asn Thr Leu Tyr Leu Val Arg Gly Ser Leu Gly Ala Asn Ile Val 
        115                 120                 125             


Ser Ser Ile Ala Ala Gly Thr Gly Ile Ala Met Leu Ile Leu Asn Leu 
    130                 135                 140                 


Thr Asn Asn Phe Ala Tyr Met Asn Asn Cys Lys Asn Val Thr Glu Asp 
145                 150                 155                 160 


Asp Gly Cys Phe Val Ala Ser Phe Thr Thr Glu Leu Val Leu Met Met 
                165                 170                 175     


Leu Phe Leu Thr Ile Leu Ala Phe Cys Ser Ala Val Leu Phe Thr Ile 
            180                 185                 190         


Tyr Arg Ile Gly Gln Glu Leu Glu Ser Lys Lys Val Pro Asp Asp Arg 
        195                 200                 205             


Leu Tyr Glu Glu Leu Asn Val Tyr Ser Pro Ile Tyr Ser Glu Leu Glu 
    210                 215                 220                 


Asp Lys Gly Glu Thr Ser Ser Pro Val Asp Ser 
225                 230                 235 


<210>  12
<211>  8200
<212>  DNA
<213>  Mus musculus

<400>  12
ggtattcaga gccaacccat cttaactgcc catccagagc acaccgcatt tctgtgtaac       60

agtatctttc attcctggat agcccaatta atgaaaaaat ggacacagaa aataggagca      120

gagcagatct tgctctccca aatccacaag aatcctccag gtaagcaaag actatttttt      180

tttcattgaa gttatttatc aagacagaaa ttcacagtgc tgggcatgca gatgccaatt      240

catagattta ttcacagatt ccagtaagtt acttaagttt cttagtgtct tactctctta      300

gcagttggga acaaggcttt tacttcactt gaaaactgga gatatcagat tttctaacat      360

tagagacttg tgcttttggg tatgagacag ggagtttgaa catacagatc tcatgcctct      420

gtatatagag ctcacaggat ttacaaaatg atcttgatcc tggttggccc ttgtgcttag      480

ggcatgggat cctgcaccca agattgaaat aggaatagag actgagctag ctcctcaaag      540

cagtcctctg catatgaagt tgtacacggc ctttattgac agagcacatg cagaaacatt      600

tctatgctaa aacctgtttg aggctgacag gcgggcatat cataagacag agatttaaga      660

aagaacttat ggaaacccag gatgaacgag agcatgcagc attttttttt tgtttgtttg      720

ttctattatg gtctatgtaa acacttggat aatgttcaag tgttgatggt tggttgcttt      780

gactctctga gacttttctc aggcaccaca ccagagagtt caactgcgtg attctcttga      840

ggaacaacta acacacaatg ctccagattc agacagttaa gaacatcaca cagggagtta      900

gaagattttt gtatgattaa gtttttgtaa atttcagtgc acctgacatt gaactcttgg      960

aagcatctcc tgccaaagca gccccaccaa agcagacatg gcggacattt ttgaagaaag     1020

agttggagtt cctgggagtg agtgcctggc ctttattctc aactcaaaat gcaggctggc     1080

tctaggacag agtatttagt tatattaaca ttttctctca tgggctgatg gtgtcctata     1140

gcattcttga taggcgagga attgacggta ttatttgcac actctgggaa gagaaaagca     1200

ttttcttata aagacattaa gttgctaggt catgaatgga aaacaggaat gaaggataca     1260

aaatgtctcc tgttagttag atagaaagaa caattatgca tgcctgacat aagtatgcaa     1320

ataaagctgt gtgtgacatg tattgataat gtatgcgtta gagtctgcta gtcatggctc     1380

aggatatata gtgaatagaa gacagtggac aaatctcaca aatgggtcaa tccaaggaaa     1440

gcctatgata ccaaacagat tttgcatatt cagtcttaca gagaaattgg tacaattttg     1500

agaaaataga tcctaacttt ataaaattca tgttttccac aggcaacaca aattctggtt     1560

ggtttgatat gcctttgttt tggaacaatt gtctgctccg tactctatgt ttcagacttt     1620

gatgaagaag tgcttttact ttataaacta ggctatccat tctggggtgc agtgctggtg     1680

agaacatatc tgtaattgtt tctgaaataa tgctaagcag agattttctt ttaatcaaag     1740

ctaattaatt ttcttttaat caagtgctta tctctagcat ttcaataata tctacagttc     1800

ttcatttata tatacatagc atctctaaat gtagtttcca aagcactttc cacatatact     1860

cattaacaag agcaaaagat tcttatcaca gttaactgtg gtttataaac cattaacata     1920

ctttcattga ctgaaaaact tgacactcta tgaaactgta aaagaataaa tacataaata     1980

tttaaaagtt aaatgactga agacttatat tcaagaaaat acccttaaca ctacctagta     2040

ataaaactac ctggtatatg tacttacata tattttatcc attaataaaa aataagattg     2100

aagagtggcc ttagtagtta aggatgcttg ctgctcttcc acaggacctg agttcagttc     2160

ttagtaccat gtcatgtgca tatggctgcc agtgactctt gctcaaggag ataagaacct     2220

tcttctggcc ttcttgggcc ttcatacaga ttagcatata tacacacaga catatacaca     2280

cactagcaca tatatgtttt taaaaatcta aaacaataca atagtgtaaa aagttatctt     2340

taagaatgga ggggaaagac atatttcaga tgagaacaaa gttaacaaca ttggatgaac     2400

acaattcctt ttaaaaattc tactgtctag aaagcaaatg actgaatgag attacaaggt     2460

catatagcct tgtatctgtg tagtacacat acaataaata gcatattctg catatagaag     2520

gtgtaagatt tgagaaaatt tgactcatat atatgtacat atatatatac atatatatgt     2580

atatataaaa tattagctta tatctcaacc tcattattac aagcctatcc atgattttgt     2640

aagttacatt catttcccta caactcttcc tgtcccactc tgctaccaga cttctcatct     2700

tgaagcaatc actataattg aaaattagtt ttcaattttt acagctttgt aggaaaagaa     2760

ctgtatgcta caatgtttta tatgcctacc tttcttcatt catatcatca ttgtgtatta     2820

tctttttatc aatagttaag ttataaaaat gtattcaaat ctaaggaaac cattgcattg     2880

gtttgatatg ctgctatgta gttcttcgat ctcctggtca tatggccaag aatcatcttg     2940

accatttacc acattttcct tgaaatttct ttccattttt caaagatttc attttaaaaa     3000

tttattcatt tattctctct ctctctgtat gtgtatgtat gtctctgtct ctgtctctgt     3060

ctctgtctct gtctctgtct ctctctctct ctctccctct ctctctctct ctctcgtgtg     3120

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatg taccagtgcc atagctcacg     3180

tagaggtcag atgtcagaga acaactgtaa gatgtcaggt ctttttttgc tactttgtga     3240

gatcaaaaaa ttgaacttgg gttctgttac aagcacttct acccactggg gcatctcata     3300

gactcaagct cctgactctt taagtgtcta ggaacacaaa tctcaatttc ttagaaggta     3360

gtctgatttt gaagcttcaa gttttacttt ttactagata tttgcaaatg tatattttca     3420

tagttaacta tatgaccatg tgctgcatat cagactccat agctacacaa ggctggcctg     3480

aagaagctga cagtgtaagt caggacatat gaactaagca ttacaataaa tgagaccact     3540

gttacagtta tacagcagat atcactagcc cttgctatct gcccagtagg tatcaaagtc     3600

aaccttatag aggagccatg taaacaaaaa aaaaaaaaaa aaacaaacaa acaaaaaaaa     3660

aaaacgaaga gcctcgggtc atctaagacc taatgagtag gagcctatgt gcttcttttg     3720

cttctttttc tctttcttac agtgtagctc aggctttcct catccgtaca accttcctgc     3780

ctcagactcc tgagagctgg gattgcaggc atgtgccacc acacagcttg gaacttgtat     3840

tttatcagga gtttcacatg gtctgtataa ggaattggct ttgagaaata ttttacagga     3900

gataataaat aatggtctca tgggagattt tagtggatag ccttctagaa catctaaaac     3960

tcatttttat attttgagga taggcgaaaa agtacaccag agagcagaaa ctcactttgg     4020

tctctcccct gtttcctttt ggacagtttg ttttgtctgg atttttgtca attatctccg     4080

aaagaaaaaa cacattgtat ctggtgagtt gcactcatgt tattcattct tccaaggtaa     4140

gaaaagtaaa attgtagggg tgttaagaga ggcacacgag aatcaactac attatagaga     4200

gtgtagatgt gtgctttttt cccccatctc tttgtgctgg aaagcatttt tgcaagataa     4260

actggataaa atcgttagaa acataaattg tgtcacctaa taaacagtga aatttgatta     4320

ctttgatacc atttaaaggg acccacacag gtattgtctt tgtatgtatt tatagtctct     4380

tttagttaag tcaattgaga tgacttgagg ataaactacg catgcatata tgtctttttt     4440

ttttcttatc ctggagattg aacctctgac cttttgcaat gcctcactct gtgttcactg     4500

ctgagtacat ccccagccct tattcttttc ttgaatgcat ctcagaggga aacatgctta     4560

ccaggtgttg agtatatttg caagagtccc ctatttaact ggggtttgga accagttttg     4620

agttactata caggaccagc tctgtaagac agatcagttg gtcagctgct gccacaccca     4680

gtcccagggc tgaatgttct atgccatcag gtgagaggca gcctgggagc aaacattgtc     4740

agtagcatcg ctgcagggac ggggatcgcc atgctgatcc tcaatctgac caataacttc     4800

gcttatatga acaactgcaa gaatgtaacc gaagacgacg gctgctttgt ggcttctttc     4860

accacagtat gtatttctta tgaaaacact aactctctgg gtcctgtctt aagtgtgaaa     4920

acccttcctc ttccagagac accgtcctcc ctttggaatc tccatctcta aaatagagtt     4980

ctgtactaag gaggtaatgg tcttactcct actcctggcc acattcctta aggttggagt     5040

catcacctcc aatcagtcac ttcctggttt cctatttatg tatcagtgtg ttatgtctgc     5100

tcttaagctt cagagttcct gagaaagggg gtgcttctct aagggaagcg attgggggta     5160

catccacctg tgactttcac tttttcgttg gttgctgttt gacaggaact ggtgttgatg     5220

atgctgtttc tcaccatcct ggccttttgc agtgctgtgt tgttcactat ctataggatt     5280

ggacaagagt tagaaagtaa aaaggtcagt aggaaatctt gactagcgta tgctggagaa     5340

tttgtgcttt attcttttag aacatgtcct gaattttctg aaattattgg ctggaaaact     5400

atttctcaaa aaactggctc ttgtatctca tattggagat cttattttat acactgaaat     5460

ggcatgagat cacagcacag tcctgtgagg ttaggcaaat ggaactgtta tcattgtaga     5520

cattgtgggt gctctggaga ggttgggtgt gagaagtgag ttatcagcag tgtgtgatgg     5580

aaacattcag ctgttgggct tttctttttt ttgggggggg ggagcttgtt atatttgttt     5640

ctgttctctc cctttctttt atatatatct ttcccctctt tattgctctc aaaaaagcct     5700

taggtttggc ttatctctta gttcatggtg acaactgtgt tttcacctgc tgcacaaact     5760

cattatattc ttggtgagaa tttccaattc tcagccactg ttgctaactc aaatctgaca     5820

aatggaacct acaacccact ctctatgtcc acttttagac acagcccagt tgttacactt     5880

cttagtgacc actgtcttca gtcagaagag aaaccaacat tttagatata gagtaacctc     5940

aataacttgt cacttacata gtttctttta gcccccattg gccaacccat ctgatctagt     6000

ttctggacat taaaggtcca gacactccag gatcatgaga ggcaaggtga aattcaaaaa     6060

gatagataga agagatgcat ccatgatgag acttctagaa atgtaaagat ctgggtaatt     6120

gatatgggac gttttttctc tttatcaggt cccagatgat cgtctttatg aagaattaaa     6180

tgtgtattca ccaatttaca gtgagttgga agacaaaggg gaaacatctt ctccagttga     6240

ttcataagaa tcaggggacc aggacaatct gattcaagta taatcttgaa agttgatctt     6300

tttacaaaat tctcgcaaaa tttctgtttg ttccacattc tgtcagtttt tcaattggat     6360

tgttctgcag atgccactct tttagttatg ctgtatctga tcttctaaat atctcccttt     6420

ttgcggatat cattcactcc aattttcttg ttttgtgtca caatttcaca tacatctttt     6480

ctggaaagtc atcaaggaat aagttggctt tattgtatgt ctactttcat gaacaaaagg     6540

aagatatgga agaattaccc tgagaattta actaacctta gataatcagg taatatttgg     6600

ctcttagttc attttagaat tctcaacagc tatagttata tgtgatatat atccaccata     6660

tcaagccttc tgtatgtatt ttaacatgat atacactttt ctgtgtagat atatttccac     6720

cctcaataat aatggggtta ttttagagac ataaagcttt gtgaaaagac gacatcatct     6780

ggttgatgag tacattcacc tgcacaggta tcgctcagtg gtttgccaat tggtgagtag     6840

taggcaatag agaacattat caaaccattc agtctagtga gatggatagg tacattcagg     6900

gatactgtga gtatccttta gtaagacaca tgggaagaat gaagaataaa ctgatgaaga     6960

cttgagctag aaggtagtca atgggaatga caagaaatga ttgtgtataa cacatgtacg     7020

taaatatcta ccaaaagttg gtagagattg gcatgtttgc ctagaatctc agcacaaggc     7080

cagcctctgt tacatagtga gttagaggcc agcctggcta tatgatatcc tacatcaaag     7140

gaccaaagga gaaattggtt caagttgtta ataccttaaa ggatagttaa acaaacagca     7200

gtttgatata ttcagtgttt gattctttaa taaaactaaa tgaataacat tgagggggag     7260

ggaagcagta atgtagaagt ctggatggtg gaagagtagt agagacaact taaaactcag     7320

ttttagactt ttgttctgag atgggtataa gagtgatcat taaataagga gggaagacac     7380

caggagaatt attttgagat agaactaagg cagtcaaact ccacatgcct acacttagaa     7440

ggggaaagta aggatcaaaa gtagaaaccc taacaagtca ggtaagcata ttacagaaca     7500

ttaaccagca gatgcctata gtggggaaaa gttagacaaa gcgaaaataa ttacccacca     7560

gagaccgtgc atgtaggctt gggaaagaca agagaaaata gcaactccaa atgaatgcta     7620

actctgaaga gggtgtgggc agaggaccag aacatttgca aaggtgccca gagagcagac     7680

catgaataga aggtagtgag gaaaaacaaa caaacaaaca aacaaacacc cccaaaacag     7740

ctgagaaaat gattttgttg ctcctattaa gatttttaaa agaaacaaaa agagatgttg     7800

aaaaatctgt ttgctgggat cagttggtgt gttctccatg tgtccaaggg acaggtaact     7860

tttctaaatc ttcatgtaag gctcgcctca tttacatccg tctctccaca cagccatatc     7920

ctcaattcac agttactcta tcacggtagt aaactgtgcg tgtgatctcc ttatgtatct     7980

tcaggcagtg tttatccagt aaatcagagt tatttaactt gatatttgta ttagcaaatg     8040

aagttgaaag aatatgaggg aagtcttgag gaagaaaatc gatggtggat atgatcatat     8100

ttcactgtac acatttgtaa agttctcaga aataaagaaa actcatttta aaaagaacca     8160

tgtacattaa aacaattgat taaatggtgc caaggacaaa                           8200


<210>  13
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  13
gaggactcag ctggaaccaa                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  14
ggcagacaga gcactcagaa                                                   20


<210>  15
<211>  328
<212>  DNA
<213>  Homo sapiens

<400>  15
atgagaccat catagtgctc ccatcaaatg tcatcaactt ctcccaagca gagaaacccg       60

aacccaccaa ccaggggcag gatagcctga agaaacatct acacgcagaa atcaaagtta      120

ttgggactat ccagatcttg tgtggcatga tggtattgag cttggggatc attttggcat      180

ctgcttcctt ctctccaaat tttacccaag tgacttctac actgttgaac tctgcttacc      240

cattcatagg accctttttt tttatcatct ctggctctct atcaatcgcc acagagaaaa      300

ggttaaccaa gcttttggtg catagcag                                         328


<210>  16
<211>  189
<212>  DNA
<213>  Homo sapiens

<400>  16
atgagaccat catagtgctc ccatcaaatg tcatcaactt ctcccaagca gagaaacccg       60

aacccaccaa ccaggggcag gatagcctga agaaacatct acacgcagaa atcaaagtta      120

ttgggtttat catctctggc tctctatcaa tcgccacaga gaaaaggtta accaagcttt      180

tggtgcata                                                              189


<210>  17
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Ser Gln Pro Val Pro Asn Glu Thr Ile Ile Val Leu Pro Ser 
1               5                   10                  15      


Asn Val Ile Asn Phe Ser Gln Ala Glu Lys Pro Glu Pro Thr Asn Gln 
            20                  25                  30          


Gly Gln Asp Ser Leu Lys Lys His Leu His Ala Glu Ile Lys Val Ile 
        35                  40                  45              


Gly Phe Ile Ile Ser Gly Ser Leu Ser Ile Ala Thr Glu Lys Arg Leu 
    50                  55                  60                  


Thr Lys Leu Leu Val His Ser Ser Leu Val Gly Ser Ile Leu Ser Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Val Gly Phe Ile Ile Leu Ser Val Lys Gln Ala Thr 
                85                  90                  95      


Leu Asn Pro Ala Ser Leu Gln Cys Glu Leu Asp Lys Asn Asn Ile Pro 
            100                 105                 110         


Thr Arg Ser Tyr Val Ser Tyr Phe Tyr His Asp Ser Leu Tyr Thr Thr 
        115                 120                 125             


Asp Cys Tyr Thr Ala Lys Ala Ser Leu Ala Gly Thr Leu Ser Leu Met 
    130                 135                 140                 


Leu Ile Cys Thr Leu Leu Glu Phe Cys Leu Ala Val Leu Thr Ala Val 
145                 150                 155                 160 


Leu Arg Trp Lys Gln Ala Tyr Ser Asp Phe Pro Gly Ser Val Leu Phe 
                165                 170                 175     


Leu Pro His Ser Tyr Ile Gly Asn Ser Gly Met Ser Ser Lys Met Thr 
            180                 185                 190         


His Asp Cys Gly Tyr Glu Glu Leu Leu Thr Ser 
        195                 200             


<210>  18
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Phe Ser Ile 
    50                  55                  60                  


Ser Gly Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu 
65                  70                  75                  80  


Val Arg Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly 
                85                  90                  95      


Thr Gly Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr 
            100                 105                 110         


Ile His Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met 
        115                 120                 125             


Ala Ser Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile 
    130                 135                 140                 


Leu Gly Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu 
145                 150                 155                 160 


Glu Leu Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu 
                165                 170                 175     


Asn Ile Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met 
            180                 185                 190         


Ser Pro Pro Ile Asp Leu 
        195             


<210>  19
<211>  250
<212>  DNA
<213>  Homo sapiens

<400>  19
gtctttacaa atgctggttt tcatcctcaa tctcactttc tcttcccaca gactatccag       60

atcttgtgtg gcatgatggt attgagcttg gggatcattt tggcatctgc ttccttctct      120

ccaaatttta cccaagtgac ttctacactg ttgaactctg cttacccatt cataggaccc      180

ttttttgtga gtagagtttc tgaggagggc aggatggggc aaagagggga ggaagatgcc      240

aatagcttag                                                             250


<210>  20
<211>  76
<212>  DNA
<213>  Homo sapiens

<400>  20
gtctttacaa atgctggttt tcatcctcaa tctcactttc tcttcccaca gactatccag       60

atcttgtgtg gcatga                                                       76


<210>  21
<211>  89
<212>  DNA
<213>  Homo sapiens

<400>  21
ttacccattc ataggaccct tttttgtgag tagagtttct gaggagggca ggatggggca       60

aagaggggag gaagatgcca atagcttag                                         89


<210>  22
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  22
tctggatagt ctgtgggaag agaaa                                             25


<210>  23
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  23
tcaatctcac tttctcttcc cacagactat ccagatcttg tgtggcatga                  50


<210>  24
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  24
gccctcctca gaaactctac tcaca                                             25


<210>  25
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  25
ttacccattc ataggaccct tttttgtgag tagagtttct gaggagggca                  50


<210>  26
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  26
atagatatat actcacaaat atggctcc                                          28


