                         SEQUENCE LISTING

<110>  Phio Pharmaceuticals Corp.
 
<120>  CHEMICALLY MODIFIED OLIGONUCLEOTIDES TARGETING BROMODOMAIN 
       CONTAINING PROTEIN 4 (BRD4) FOR IMMUNOTHERAPY

<130>  R0659.70055WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/932,813
<151>  2019-11-08

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  1
uacuggaaug cucaggaaug                                                   20


<210>  2
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  2
ggaaugcuca ggaauguauc                                                   20


<210>  3
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  3
aauguaucca ggacuucaac                                                   20


<210>  4
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  4
ucaugauagu ccaggcaaaa                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  5
ccacgguacc aaacacaacu                                                   20


<210>  6
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  6
cucaaggaga uguuugccaa                                                   20


<210>  7
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  7
aaggagaugu uugccaagaa                                                   20


<210>  8
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  8
cacgacuacu gugacaucau                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  9
auggacauga gcacaaucaa                                                   20


<210>  10
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  10
ggacaugagc acaaucaagu                                                   20


<210>  11
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  11
uccgauugau guucuccaac                                                   20


<210>  12
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  12
auugauguuc uccaacugcu                                                   20


<210>  13
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  13
accuccuguu ugcggaagaa                                                   20


<210>  14
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  14
cuguuugcgg aagaaaagga                                                   20


<210>  15
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  15
auaaagaagc gcuuggaaaa                                                   20


<210>  16
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  16
ucaagacacu auggaaacac                                                   20


<210>  17
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  17
cuccaacugc uauaaguaca                                                   20


<210>  18
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  18
acuacuguga caucaucaag                                                   20


<210>  19
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  19
aaaugcgcuu ugccaagaug                                                   20


<210>  20
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  20
uccaggaugu guucgaaaug                                                   20


<210>  21
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  21
ccuaaaaaga cgaagaaaaa                                                   20


<210>  22
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  22
agaaaguuga ugugauugcc                                                   20


<210>  23
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  23
uugaaaucga cuuugagacc                                                   20


<210>  24
<211>  20
<212>  RNA
<213>  Homo Sapiens

<400>  24
ugacagcgaa gacuccgaaa                                                   20


<210>  25
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  25
aaacaacuau uacuggaaug cucaggaaug uauccaggac u                           41


<210>  26
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  26
aacuauuacu ggaaugcuca ggaauguauc caggacuuca a                           41


<210>  27
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  27
aaugcucagg aauguaucca ggacuucaac acuauguuua c                           41


<210>  28
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  28
gaaaccgaga ucaugauagu ccaggcaaaa ggaagaggac g                           41


<210>  29
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  29
ccuggcguuu ccacgguacc aaacacaacu caagcaucga c                           41


<210>  30
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  30
cagcggcauc cucaaggaga uguuugccaa gaagcacgcc g                           41


<210>  31
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  31
cggcauccuc aaggagaugu uugccaagaa gcacgccgcc u                           41


<210>  32
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  32
acugggccua cacgacuacu gugacaucau caagcacccc a                           41


<210>  33
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  33
caagcacccc auggacauga gcacaaucaa gucuaaacug g                           41


<210>  34
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  34
agcaccccau ggacaugagc acaaucaagu cuaaacugga g                           41


<210>  35
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  35
ggugcugacg uccgauugau guucuccaac ugcuauaagu a                           41


<210>  36
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  36
cugacguccg auugauguuc uccaacugcu auaaguacaa c                           41


<210>  37
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  37
gcgcuauguc accuccuguu ugcggaagaa aaggaaaccu c                           41


<210>  38
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  38
augucaccuc cuguuugcgg aagaaaagga aaccucaagc u                           41


<210>  39
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  39
uaugggaaca auaaagaagc gcuuggaaaa caacuauuac u                           41


<210>  40
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  40
agaguggugc ucaagacacu auggaaacac caguuugcau g                           41


<210>  41
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  41
gauugauguu cuccaacugc uauaaguaca acccuccuga c                           41


<210>  42
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  42
ggccuacacg acuacuguga caucaucaag caccccaugg a                           41


<210>  43
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  43
gauguguucg aaaugcgcuu ugccaagaug ccggacgagc c                           41


<210>  44
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  44
gcccgcaagc uccaggaugu guucgaaaug cgcuuugcca a                           41


<210>  45
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  45
ggaaccuccu ccuaaaaaga cgaagaaaaa uaauagcagc a                           41


<210>  46
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  46
ccucaagcug agaaaguuga ugugauugcc ggcuccucca a                           41


<210>  47
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  47
cccgacgaga uugaaaucga cuuugagacc cugaagccgu c                           41


<210>  48
<211>  41
<212>  RNA
<213>  Homo Sapiens

<400>  48
ccagcuccuc ugacagcgaa gacuccgaaa cagagauggc u                           41


<210>  49
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  49
gaaugcucag gaaua                                                        15


<210>  50
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  50
uauuccugag cauuccagua                                                   20


<210>  51
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  51
gcucaggaau guaua                                                        15


<210>  52
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  52
uauacauucc ugagcauucc                                                   20


<210>  53
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  53
auccaggacu ucaaa                                                        15


<210>  54
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  54
uuugaagucc uggauacauu                                                   20


<210>  55
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  55
auaguccagg caaaa                                                        15


<210>  56
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  56
uuuugccugg acuaucauga                                                   20


<210>  57
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  57
guaccaaaca caaca                                                        15


<210>  58
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  58
uguuguguuu gguaccgugg                                                   20


<210>  59
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  59
ggagauguuu gccaa                                                        15


<210>  60
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  60
uuggcaaaca ucuccuugag                                                   20


<210>  61
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  61
gauguuugcc aagaa                                                        15


<210>  62
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  62
uucuuggcaa acaucuccuu                                                   20


<210>  63
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  63
cuacugugac aucaa                                                        15


<210>  64
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  64
uugaugucac aguagucgug                                                   20


<210>  65
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  65
caugagcaca aucaa                                                        15


<210>  66
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  66
uugauugugc ucauguccau                                                   20


<210>  67
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  67
ugagcacaau caaga                                                        15


<210>  68
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  68
ucuugauugu gcucaugucc                                                   20


<210>  69
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  69
uugauguucu ccaaa                                                        15


<210>  70
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  70
uuuggagaac aucaaucgga                                                   20


<210>  71
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  71
uguucuccaa cugca                                                        15


<210>  72
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  72
ugcaguugga gaacaucaau                                                   20


<210>  73
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  73
cuguuugcgg aagaa                                                        15


<210>  74
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  74
uucuuccgca aacaggaggu                                                   20


<210>  75
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  75
ugcggaagaa aagga                                                        15


<210>  76
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  76
uccuuuucuu ccgcaaacag                                                   20


<210>  77
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  77
gaagcgcuug gaaaa                                                        15


<210>  78
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  78
uuuuccaagc gcuucuuuau                                                   20


<210>  79
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  79
acacuaugga aacaa                                                        15


<210>  80
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  80
uuguuuccau agugucuuga                                                   20


<210>  81
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  81
acugcuauaa guaca                                                        15


<210>  82
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  82
uguacuuaua gcaguuggag                                                   20


<210>  83
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  83
ugugacauca ucaaa                                                        15


<210>  84
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  84
uuugaugaug ucacaguagu                                                   20


<210>  85
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  85
cgcuuugcca agaua                                                        15


<210>  86
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  86
uaucuuggca aagcgcauuu                                                   20


<210>  87
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  87
gauguguucg aaaua                                                        15


<210>  88
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  88
uauuucgaac acauccugga                                                   20


<210>  89
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  89
aaagacgaag aaaaa                                                        15


<210>  90
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  90
uuuuucuucg ucuuuuuagg                                                   20


<210>  91
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  91
guugauguga uugca                                                        15


<210>  92
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  92
ugcaaucaca ucaacuuucu                                                   20


<210>  93
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  93
aucgacuuug agaca                                                        15


<210>  94
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  94
ugucucaaag ucgauuucaa                                                   20


<210>  95
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2' fluoro nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by cholesterol-TEG-Glyceryl

<400>  95
gcgaagacuc cgaaa                                                        15


<210>  96
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 5' inorganic Phosphate

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  phosphorothioate linkages

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2' fluoro nucleotide

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl nucleotide

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2' fluoro nucleotide

<400>  96
uuucggaguc uucgcuguca                                                   20


