                         SEQUENCE LISTING

<110>  MEDIMMUNE, LLC
 
<120>  ENDOTHELIAL LIPASE ANTIBODIES FOR THE TREATMENT OF CARDIOVASCULAR
       DISEASES

<130>  2943.134PC03

<150>  US 63/104,410
<151>  2020-10-22

<150>  US 62/940,164
<151>  2019-11-25

<150>  US 62/932,257
<151>  2019-11-07

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Heavy Chain CDR1

<400>  1

Asn Tyr Ala Leu Asn 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Heavy Chain CDR2

<400>  2

Trp Ile Asn Thr Tyr Ser Gly Val Gly Thr Tyr Ala Gly Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Heavy Chain CDR3

<400>  3

Arg Gly Phe Tyr Gly Arg Arg Phe Phe Asp Val 
1               5                   10      


<210>  4
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Light Chain CDR1

<400>  4

Lys Ala Ser Gln Ser Val Asp Tyr Asp Val Asp Ser Tyr Met His 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Light Chain CDR2

<400>  5

Ala Ala Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Light Chain CDR3

<400>  6

Gln Gln Thr Ile Glu Asp Pro Pro Thr 
1               5                   


<210>  7
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Variable Heavy  Chain

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Gly Thr Tyr Ala Gly Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Phe Tyr Gly Arg Arg Phe Phe Asp Val Trp Gly Lys 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Variable Light Chain

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Val Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Ala Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Thr Ile 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  447
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Heavy Chain

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Gly Thr Tyr Ala Gly Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Phe Tyr Gly Arg Arg Phe Phe Asp Val Trp Gly Lys 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  10
<211>  218
<212>  PRT
<213>  artificial sequence

<220>
<223>  MEDI5884 Light Chain

<400>  10

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Val Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Ala Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Thr Ile 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  11
<211>  480
<212>  PRT
<213>  Homo Sapiens

<400>  11

Ser Pro Val Pro Phe Gly Pro Glu Gly Arg Leu Glu Asp Lys Leu His 
1               5                   10                  15      


Lys Pro Lys Ala Thr Gln Thr Glu Val Lys Pro Ser Val Arg Phe Asn 
            20                  25                  30          


Leu Arg Thr Ser Lys Asp Pro Glu His Glu Gly Cys Tyr Leu Ser Val 
        35                  40                  45              


Gly His Ser Gln Pro Leu Glu Asp Cys Ser Phe Asn Met Thr Ala Lys 
    50                  55                  60                  


Thr Phe Phe Ile Ile His Gly Trp Thr Met Ser Gly Ile Phe Glu Asn 
65                  70                  75                  80  


Trp Leu His Lys Leu Val Ser Ala Leu His Thr Arg Glu Lys Asp Ala 
                85                  90                  95      


Asn Val Val Val Val Asp Trp Leu Pro Leu Ala His Gln Leu Tyr Thr 
            100                 105                 110         


Asp Ala Val Asn Asn Thr Arg Val Val Gly His Ser Ile Ala Arg Met 
        115                 120                 125             


Leu Asp Trp Leu Gln Glu Lys Asp Asp Phe Ser Leu Gly Asn Val His 
    130                 135                 140                 


Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ala Gly Tyr Ala Gly Asn 
145                 150                 155                 160 


Phe Val Lys Gly Thr Val Gly Arg Ile Thr Gly Leu Asp Pro Ala Gly 
                165                 170                 175     


Pro Met Phe Glu Gly Ala Asp Ile His Lys Arg Leu Ser Pro Asp Asp 
            180                 185                 190         


Ala Asp Phe Val Asp Val Leu His Thr Tyr Thr Arg Ser Phe Gly Leu 
        195                 200                 205             


Ser Ile Gly Ile Gln Met Pro Val Gly His Ile Asp Ile Tyr Pro Asn 
    210                 215                 220                 


Gly Gly Asp Phe Gln Pro Gly Cys Gly Leu Asn Asp Val Leu Gly Ser 
225                 230                 235                 240 


Ile Ala Tyr Gly Thr Ile Thr Glu Val Val Lys Cys Glu His Glu Arg 
                245                 250                 255     


Ala Val His Leu Phe Val Asp Ser Leu Val Asn Gln Asp Lys Pro Ser 
            260                 265                 270         


Phe Ala Phe Gln Cys Thr Asp Ser Asn Arg Phe Lys Lys Gly Ile Cys 
        275                 280                 285             


Leu Ser Cys Arg Lys Asn Arg Cys Asn Ser Ile Gly Tyr Asn Ala Lys 
    290                 295                 300                 


Lys Met Arg Asn Lys Arg Asn Ser Lys Met Tyr Leu Lys Thr Arg Ala 
305                 310                 315                 320 


Gly Met Pro Phe Arg Val Tyr His Tyr Gln Met Lys Ile His Val Phe 
                325                 330                 335     


Ser Tyr Lys Asn Met Gly Glu Ile Glu Pro Thr Phe Tyr Val Thr Leu 
            340                 345                 350         


Tyr Gly Thr Asn Ala Asp Ser Gln Thr Leu Pro Leu Glu Ile Val Glu 
        355                 360                 365             


Arg Ile Glu Gln Asn Ala Thr Asn Thr Phe Leu Val Tyr Thr Glu Glu 
    370                 375                 380                 


Asp Leu Gly Asp Leu Leu Lys Ile Gln Leu Thr Trp Glu Gly Ala Ser 
385                 390                 395                 400 


Gln Ser Trp Tyr Asn Leu Trp Lys Glu Phe Arg Ser Tyr Leu Ser Gln 
                405                 410                 415     


Pro Arg Asn Pro Gly Arg Glu Leu Asn Ile Arg Arg Ile Arg Val Lys 
            420                 425                 430         


Ser Gly Glu Thr Gln Arg Lys Leu Thr Phe Cys Thr Glu Asp Pro Glu 
        435                 440                 445             


Asn Thr Ser Ile Ser Pro Gly Arg Glu Leu Trp Phe Arg Lys Cys Arg 
    450                 455                 460                 


Asp Gly Trp Arg Met Lys Asn Glu Thr Ser Pro Thr Val Glu Leu Pro 
465                 470                 475                 480 


<210>  12
<211>  327
<212>  PRT
<213>  artificial sequence

<220>
<223>  Constant Region of a Human IgG4P heavy chain

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  13
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Constant Region of a Human C Kappa Light Chain

<400>  13

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  14
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  HS9 variable heavy chain sequence

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Ser Pro Ser Gly Gly Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Pro Leu Tyr Ala Ser Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  15
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  HS9 variable light chain sequence

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Lys Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Arg Tyr Ser Leu Trp Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


