                         SEQUENCE LISTING

<110>  Kunjapur, Aditya
 
<120>  BIOSYNTHESIS OF PARA-NITRO-L-PHENYLALANINE

<130>  ADKU-100WO

<150>  62/930,720
<151>  2019-11-05

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  686
<212>  PRT
<213>  Streptomyces venezuelae

<400>  1

Met Arg Thr Leu Leu Ile Asp Asn Tyr Asp Ser Phe Thr His Asn Leu 
1               5                   10                  15      


Phe Gln Tyr Ile Gly Glu Ala Thr Gly Gln Pro Pro Val Val Val Pro 
            20                  25                  30          


Asn Asp Ala Asp Trp Ser Arg Leu Pro Leu Glu Asp Phe Asp Ala Ile 
        35                  40                  45              


Val Val Ser Pro Gly Pro Gly Ser Pro Asp Arg Glu Arg Asp Phe Gly 
    50                  55                  60                  


Ile Ser Arg Arg Ala Ile Thr Asp Ser Gly Leu Pro Val Leu Gly Val 
65                  70                  75                  80  


Cys Leu Gly His Gln Gly Ile Ala Gln Leu Phe Gly Gly Thr Val Gly 
                85                  90                  95      


Leu Ala Pro Glu Pro Met His Gly Arg Val Ser Glu Val Arg His Thr 
            100                 105                 110         


Gly Glu Asp Val Phe Arg Gly Leu Pro Ser Pro Phe Thr Ala Val Arg 
        115                 120                 125             


Tyr His Ser Leu Ala Ala Thr Asp Leu Pro Asp Glu Leu Glu Pro Leu 
    130                 135                 140                 


Ala Trp Ser Asp Asp Gly Val Val Met Gly Leu Arg His Arg Glu Lys 
145                 150                 155                 160 


Pro Leu Trp Gly Val Gln Phe His Pro Glu Ser Ile Gly Ser Asp Phe 
                165                 170                 175     


Gly Arg Glu Ile Met Ala Asn Phe Arg Asp Leu Ala Leu Ala His His 
            180                 185                 190         


Arg Ala Arg Arg Asp Ala Ala Asp Ser Pro Tyr Glu Leu His Val Arg 
        195                 200                 205             


Arg Val Asp Val Leu Pro Asp Ala Glu Glu Val Arg Arg Gly Cys Leu 
    210                 215                 220                 


Pro Gly Glu Gly Ala Thr Phe Trp Leu Asp Ser Ser Ser Val Leu Glu 
225                 230                 235                 240 


Gly Ala Ser Arg Phe Ser Phe Leu Gly Asp Asp Arg Gly Pro Leu Ala 
                245                 250                 255     


Glu Tyr Leu Thr Tyr Arg Val Ala Asp Gly Val Val Ser Val Arg Gly 
            260                 265                 270         


Ser Asp Gly Thr Thr Thr Arg Thr Arg Arg Pro Phe Phe Ser Tyr Leu 
        275                 280                 285             


Glu Glu Gln Leu Glu Arg Arg Arg Val Pro Val Ala Pro Asp Leu Pro 
    290                 295                 300                 


Phe Glu Phe Asn Leu Gly Tyr Val Gly Tyr Leu Gly Tyr Glu Leu Lys 
305                 310                 315                 320 


Ala Glu Thr Thr Gly Asp Pro Ala His Arg Ser Pro His Pro Asp Ala 
                325                 330                 335     


Ala Phe Leu Phe Ala Asp Arg Ala Ile Ala Leu Asp His Gln Glu Gly 
            340                 345                 350         


Cys Cys Tyr Leu Leu Ala Leu Asp Arg Arg Gly His Asp Asp Gly Ala 
        355                 360                 365             


Arg Ala Trp Leu Arg Glu Thr Ala Glu Thr Leu Thr Gly Leu Ala Val 
    370                 375                 380                 


Arg Val Pro Ala Glu Pro Thr Pro Ala Met Val Phe Gly Val Pro Glu 
385                 390                 395                 400 


Ala Ala Ala Gly Phe Gly Pro Leu Ala Arg Ala Arg His Asp Lys Asp 
                405                 410                 415     


Ala Tyr Leu Lys Arg Ile Asp Glu Cys Leu Lys Glu Ile Arg Asn Gly 
            420                 425                 430         


Glu Ser Tyr Glu Ile Cys Leu Thr Asn Met Val Thr Ala Pro Thr Glu 
        435                 440                 445             


Ala Thr Ala Leu Pro Leu Tyr Ser Ala Leu Arg Ala Ile Ser Pro Val 
    450                 455                 460                 


Pro Tyr Gly Ala Leu Leu Glu Phe Pro Glu Leu Ser Val Leu Ser Ala 
465                 470                 475                 480 


Ser Pro Glu Arg Phe Leu Thr Ile Gly Ala Asp Gly Gly Val Glu Ser 
                485                 490                 495     


Lys Pro Ile Lys Gly Thr Arg Pro Arg Gly Gly Thr Ala Glu Glu Asp 
            500                 505                 510         


Glu Arg Leu Arg Ala Asp Leu Ala Gly Arg Glu Lys Asp Arg Ala Glu 
        515                 520                 525             


Asn Leu Met Ile Val Asp Leu Val Arg Asn Asp Leu Asn Ser Val Cys 
    530                 535                 540                 


Ala Ile Gly Ser Val His Val Pro Arg Leu Phe Glu Val Glu Thr Tyr 
545                 550                 555                 560 


Ala Pro Val His Gln Leu Val Ser Thr Ile Arg Gly Arg Leu Arg Pro 
                565                 570                 575     


Gly Thr Ser Thr Ala Ala Cys Val Arg Ala Ala Phe Pro Gly Gly Ser 
            580                 585                 590         


Met Thr Gly Ala Pro Lys Lys Arg Thr Met Glu Ile Ile Asp Arg Leu 
        595                 600                 605             


Glu Glu Gly Pro Arg Gly Val Tyr Ser Gly Ala Leu Gly Trp Phe Ala 
    610                 615                 620                 


Leu Ser Gly Ala Ala Asp Leu Ser Ile Val Ile Arg Thr Ile Val Leu 
625                 630                 635                 640 


Ala Asp Gly Arg Ala Glu Phe Gly Val Gly Gly Ala Ile Val Ser Leu 
                645                 650                 655     


Ser Asp Gln Glu Glu Glu Phe Thr Glu Thr Val Val Lys Ala Arg Ala 
            660                 665                 670         


Met Val Thr Ala Leu Asp Gly Ser Ala Val Ala Gly Ala Arg 
        675                 680                 685     


<210>  2
<211>  101
<212>  PRT
<213>  Streptomyces venezuelae

<400>  2

Met Thr Glu Gln Asn Glu Leu Gln Arg Leu Arg Ala Glu Leu Asp Ala 
1               5                   10                  15      


Leu Asp Gly Thr Leu Leu Asp Thr Val Arg Arg Arg Ile Asp Leu Gly 
            20                  25                  30          


Val Arg Ile Ala Arg Tyr Lys Ser Arg His Gly Val Pro Met Met Gln 
        35                  40                  45              


Pro Gly Arg Val Ser Leu Val Lys Asp Arg Ala Ala Arg Tyr Ala Ala 
    50                  55                  60                  


Asp His Gly Leu Asp Glu Ser Phe Leu Val Asn Leu Tyr Asp Val Ile 
65                  70                  75                  80  


Ile Thr Glu Met Cys Arg Val Glu Asp Leu Val Met Ser Pro Ser Cys 
                85                  90                  95      


Thr Lys Glu Val Val 
            100     


<210>  3
<211>  328
<212>  PRT
<213>  Streptomyces venezuelae

<400>  3

Met Ser Gly Phe Pro Arg Ser Val Val Val Gly Gly Ser Gly Ala Val 
1               5                   10                  15      


Gly Gly Met Phe Ala Gly Leu Leu Arg Glu Ala Gly Ser Arg Thr Leu 
            20                  25                  30          


Val Val Asp Leu Val Pro Pro Pro Gly Arg Pro Asp Ala Cys Leu Val 
        35                  40                  45              


Gly Asp Val Thr Ala Pro Gly Pro Glu Leu Ala Ala Ala Leu Arg Asp 
    50                  55                  60                  


Ala Asp Leu Val Leu Leu Ala Val His Glu Asp Val Ala Leu Lys Ala 
65                  70                  75                  80  


Val Ala Pro Val Thr Arg Leu Met Arg Pro Gly Ala Leu Leu Ala Asp 
                85                  90                  95      


Thr Leu Ser Val Arg Thr Gly Met Ala Ala Glu Leu Ala Ala His Ala 
            100                 105                 110         


Pro Gly Val Gln His Val Gly Leu Asn Pro Met Phe Ala Pro Ala Ala 
        115                 120                 125             


Gly Met Thr Gly Arg Pro Val Ala Ala Val Val Thr Arg Asp Gly Pro 
    130                 135                 140                 


Gly Val Thr Ala Leu Leu Arg Leu Val Glu Gly Gly Gly Gly Arg Pro 
145                 150                 155                 160 


Val Arg Leu Thr Ala Glu Glu His Asp Arg Thr Thr Ala Ala Thr Gln 
                165                 170                 175     


Ala Leu Thr His Ala Val Ile Leu Ser Phe Gly Leu Ala Leu Ala Arg 
            180                 185                 190         


Leu Gly Val Asp Val Arg Ala Leu Ala Ala Thr Ala Pro Pro Pro His 
        195                 200                 205             


Gln Val Leu Leu Ala Leu Leu Ala Arg Val Leu Gly Gly Ser Pro Glu 
    210                 215                 220                 


Val Tyr Gly Asp Ile Gln Arg Ser Asn Pro Arg Ala Ala Ser Ala Arg 
225                 230                 235                 240 


Arg Ala Leu Ala Glu Ala Leu Arg Ser Phe Ala Ala Leu Ile Gly Asp 
                245                 250                 255     


Asp Pro Asp Arg Ala Glu Asp Pro Asp Arg Ala Asp Asp Pro Asp Arg 
            260                 265                 270         


Thr Asp Asn Pro Gly His Pro Gly Gly Cys Asp Gly Ala Gly Asn Leu 
        275                 280                 285             


Asp Gly Val Phe Glu Glu Leu Arg Arg Leu Met Gly Pro Glu Leu Ala 
    290                 295                 300                 


Ala Gly Gln Asp His Cys Gln Glu Leu Phe Arg Thr Leu His Arg Thr 
305                 310                 315                 320 


Asp Asp Glu Gly Glu Lys Asp Arg 
                325             


<210>  4
<211>  199
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  4

Met Phe Lys Thr Leu Ile Ile Asp Asn Phe Asp Ser Phe Thr Tyr Asn 
1               5                   10                  15      


Leu Tyr Gln Tyr Met Gly Gln Val Thr Gly Glu Glu Pro Asp Val Phe 
            20                  25                  30          


Thr Asn Asp Ala Ser Pro His Asp Ile Asp Leu Gly Arg Tyr Asp Cys 
        35                  40                  45              


Ile Ile Val Ser Pro Gly Pro Gly Thr Pro Lys Arg Arg Gln Asp Val 
    50                  55                  60                  


Gly Ile Ser Glu Asp Met Ile Arg Asp Ala His Val Pro Leu Leu Gly 
65                  70                  75                  80  


Val Cys Leu Gly His Gln Cys Met Ala His Val His Gly Met Asp Val 
                85                  90                  95      


Asp His Ala Pro Glu Pro Met His Gly Arg Val Arg His Ile Arg His 
            100                 105                 110         


Asn Asn Glu Gly Val Phe Lys Gly Leu Pro Val Asp Met Pro Val Val 
        115                 120                 125             


Arg Tyr His Ser Leu Val Val Lys Ala Leu Lys Gly Pro Phe Glu Leu 
    130                 135                 140                 


Ser Ala Trp Asp Glu Asn Gly Met Ile His Gly Ile Arg His Thr Glu 
145                 150                 155                 160 


Arg Pro Leu Tyr Gly Ile Gln Phe His Pro Glu Ser Ile Cys Thr Asp 
                165                 170                 175     


Ser Gly Leu Asp Leu Leu Arg Asn Phe Arg Asp Ile Ala His Arg His 
            180                 185                 190         


Lys Leu Glu Arg Leu Pro Arg 
        195                 


<210>  5
<211>  486
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  5

Met Thr Thr Phe Asp Val Glu Val Arg Ala Leu Asp Tyr Asn Pro Asp 
1               5                   10                  15      


Pro Leu Arg Val Phe Arg Ser Glu Phe Leu Ala Ser Pro Arg His Phe 
            20                  25                  30          


Phe Leu Glu Ser Ser Val Val Lys Pro Gly Phe Ser Arg Phe Ser Phe 
        35                  40                  45              


Met Gly Asp Ser His Gly Arg Leu Ala Glu Thr Ile Thr Tyr Asp Thr 
    50                  55                  60                  


Ser Ser Arg Ser Val Arg Val Glu Arg Ser Asp Gly Val Thr Arg Glu 
65                  70                  75                  80  


Pro Thr Ser Asp Phe Leu Glu Leu Met Ala Ala Arg Leu Asn His Tyr 
                85                  90                  95      


His Cys Glu Gln Pro Gln Trp Leu Pro Phe Asp Phe Asn Leu Gly Tyr 
            100                 105                 110         


Val Gly Leu Leu Gly Tyr Glu Leu Lys Cys Glu Thr Leu Gly Ala Gln 
        115                 120                 125             


Ala Tyr Ala Ser His Ser His Asp Ala Ala Phe Ile Leu Ala Thr Arg 
    130                 135                 140                 


Met Ile Ala Phe Asp His Ala Glu Gln Arg Cys Tyr Leu Leu Tyr Leu 
145                 150                 155                 160 


Val Glu His Asp Glu Asp Arg Gln Asp Ala Ala Gln Trp Phe Asp Gln 
                165                 170                 175     


Val Gln Ala Arg Leu Arg Glu Gln Pro Gln Val Ala Glu Pro Val Ser 
            180                 185                 190         


Arg Gln Arg Lys Leu Ser Leu Pro Gln Val Glu Ala Trp Ile Gln Glu 
        195                 200                 205             


His Ala Cys Ile Arg His Ser Lys Gln Arg Tyr Ile Asp Lys Ile Asn 
    210                 215                 220                 


Glu Ala Gln Arg Glu Ile Ile Asp Gly Glu Thr Tyr Glu Val Cys Leu 
225                 230                 235                 240 


Thr Asn Leu Ile Glu Phe Ala Phe Ala Asp Ser Ser Phe Asp Leu Tyr 
                245                 250                 255     


Cys Val Met Arg Glu Leu Thr Pro Ala Pro His Ala Gly Tyr Phe Ser 
            260                 265                 270         


Ile Pro Asp Phe Gln Ile Ile Ser Ser Ser Pro Glu Arg Phe Leu Lys 
        275                 280                 285             


Ile Asp Arg His His Gln Val Glu Ala Lys Pro Ile Lys Gly Thr Arg 
    290                 295                 300                 


Pro Arg Gly Arg Cys Ala Glu Glu Asp Gln Glu Leu Ile Glu Gln Met 
305                 310                 315                 320 


Arg Gly Asp Glu Lys Asp Arg Ala Glu Asn Leu Met Ile Val Asp Leu 
                325                 330                 335     


Leu Arg Asn Asp Leu Gly Gln Val Cys Thr Ile Gly Ser Val Arg Val 
            340                 345                 350         


Pro Ala Leu Phe Ala Val Glu Thr Tyr Ser His Val His Gln Leu Val 
        355                 360                 365             


Ser Thr Ile Ser Gly Gln Leu Lys Pro Ser Leu Ser Ala Val Asp Cys 
    370                 375                 380                 


Val Arg Ala Thr Phe Pro Gly Gly Ser Met Thr Gly Ala Pro Lys Lys 
385                 390                 395                 400 


Arg Thr Met Glu Ile Ile Asp Arg Leu Glu Glu Gly Pro Arg Gly Ala 
                405                 410                 415     


Tyr Ser Gly Ser Leu Gly Trp Phe Gly Leu Gly Gly Ala Cys Asp Leu 
            420                 425                 430         


Asn Ile Met Ile Arg Ser Ile Thr Val Asp Ala Gln Val Ala Arg Phe 
        435                 440                 445             


Gly Val Gly Gly Ala Ile Thr Ser Leu Ser Asp Pro Leu Gly Glu Tyr 
    450                 455                 460                 


Ile Glu Thr Met Val Lys Ala Ser Gly Val Val Glu Ala Val Thr Gln 
465                 470                 475                 480 


Leu Arg Ser Thr Ser Val 
                485     


<210>  6
<211>  420
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  6

Met Ser Leu Ser Ser Pro His Arg His Ala Val Val Val Gly Ile Leu 
1               5                   10                  15      


Gly Ser Ile Gly Gln Leu Leu Ala Asn Gln Leu Ser Ile Ala Gly Tyr 
            20                  25                  30          


Ser Val Thr Gly Ile Asp Ile Ala Val Asp Asp Gln Ser Ala Gln Pro 
        35                  40                  45              


His Thr Val Ile Gln Gly Asp Val Leu Arg Pro Gly Asn Glu Ile Lys 
    50                  55                  60                  


Gln Arg Leu Gly Asp Ala Gln Ile Leu Val Leu Ala Leu Ala Gln Asn 
65                  70                  75                  80  


Val Leu Ser Glu Ala Leu Pro Gln Leu Leu Pro Ser Leu Arg Ser Asp 
                85                  90                  95      


Cys Leu Ile Val Asp Thr Leu Ser Ile Lys Ser Glu Phe Ala Asp Phe 
            100                 105                 110         


Val Ala Thr Leu Asp Val Ala Gln Pro Met Val Gly Ile Asn Pro Met 
        115                 120                 125             


Phe Ser Gly Asp Leu Asp Pro Ala Gly Arg Pro Val Ala Val Val Thr 
    130                 135                 140                 


Tyr Arg Asp Gly Asp Gly Asp Ala Val Ala Arg Leu Val Glu Trp Leu 
145                 150                 155                 160 


His Ser Trp Pro Ala Asn Val Phe Gln Met Thr Ala Ser Glu His Asp 
                165                 170                 175     


Arg Thr Met Ala Tyr Leu Gln Thr Leu Gly His Ala Leu Val Met Gly 
            180                 185                 190         


Met Gly Leu Thr Leu Ala Glu Ser Ala Ala Pro Leu Glu Asn Leu Phe 
        195                 200                 205             


Glu Leu Ala Pro Pro Pro Phe Lys Val Met Leu Ala Leu Leu Ala Arg 
    210                 215                 220                 


Met Thr Lys Asn His Pro Asp Val Tyr Trp Glu Ile Gln Ser Asn Asn 
225                 230                 235                 240 


Pro Tyr Ser Gln Glu Ile Arg Ser Arg Met Leu Ala Gln Leu Gly Lys 
                245                 250                 255     


Leu Asp Asp Arg Val Asn Ser Gly Ser Arg Leu Asp Tyr His Val Ser 
            260                 265                 270         


Met Ala Met Leu Arg Asn Ala Leu Lys Pro Leu Asn Pro Gly Leu Glu 
        275                 280                 285             


Asn Thr Ser Arg His Leu Phe Glu Gln Leu Asp Gln Ala Pro Lys Ala 
    290                 295                 300                 


Ile Glu Gly Ala Pro Glu Ser Leu Ala Asp Tyr Arg Gln Arg Ile Asp 
305                 310                 315                 320 


His Ile Asp Asp Gln Leu Val Asp Leu Leu Gly Gln Arg Leu Ser Leu 
                325                 330                 335     


Ile Arg Glu Val Ala Gln Ser Lys Lys Asp His Gln Thr Ala Val Met 
            340                 345                 350         


Gln Pro Asn Arg Val Val Gln Val Val Glu Arg Cys Lys Ala Arg Gly 
        355                 360                 365             


Arg Arg His His Ile Arg Glu Ser Leu Ile Glu Gln Leu Tyr Gly Leu 
    370                 375                 380                 


Ile Ile Asp Glu Ala Cys Gln Ile Glu Tyr Asp Val Ile Gly Gly Pro 
385                 390                 395                 400 


Arg Glu Ser Leu Tyr Glu Ala Ser Pro Ser Ala Phe Thr Ser Ser Ala 
                405                 410                 415     


Glu Lys Thr Gln 
            420 


<210>  7
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Thr Met Ile Thr Pro Ser Leu His Ala Cys Arg Ser Met Pro Glu 
1               5                   10                  15      


Ser Gln Leu Leu Asn Lys Ile Thr Asp Thr Trp Tyr Ala Lys Ala Thr 
            20                  25                  30          


Val Arg Ser Thr Pro Arg Ile Leu Val Pro Asp Tyr Ser Ser Glu Gln 
        35                  40                  45              


Leu Ile Tyr Pro Val Ala Arg Cys Ser Ile Cys Glu His Pro Leu Val 
    50                  55                  60                  


Leu Glu Leu Gly Pro Gln Val Arg Ser Tyr Ile Leu Thr Gln Ala Ala 
65                  70                  75                  80  


Tyr Gln Phe Leu Tyr Gly Val Gly Leu Leu Glu Thr Lys Phe Val Ile 
                85                  90                  95      


Gln Cys Cys Leu Asp Met Leu His Asn Asn Ile Lys Asp Ile Ser Asp 
            100                 105                 110         


Ala Ala Lys Leu Gln Ala Leu Thr Val Ile Val Asp Glu Gly Tyr His 
        115                 120                 125             


Ala His Val Ala Leu Asp Tyr Ile Ile Gln Met Lys Lys Lys Ser Ala 
    130                 135                 140                 


Ile Glu Pro Leu Glu Val Pro Gln Thr Asn Arg Lys Leu Asp Ala Thr 
145                 150                 155                 160 


Ala Arg Ala Tyr Ala Ser Leu Pro Glu Ser Met Arg Met Asp Phe Gln 
                165                 170                 175     


Leu Leu Ala Val Thr Leu Ala Glu Asn Val Leu Thr Asp Glu Val Ala 
            180                 185                 190         


Asn Leu Gly Arg Glu Arg Glu Leu Ala Gln Ser Phe Thr Thr Leu Met 
        195                 200                 205             


Met Asp His Val Arg Asp Glu Gly Arg His Ser Arg Phe Phe Ala Asp 
    210                 215                 220                 


Leu Met Lys Glu Arg Trp Pro Gln Leu Pro Arg Ala Thr Gln Glu His 
225                 230                 235                 240 


Phe Gly Leu Met Leu Pro Ala Tyr Leu Asp Asp Phe Leu Gly Ala Asp 
                245                 250                 255     


Leu Ser Arg Gly Phe Glu Arg Lys Ile Leu Ala His Cys Gly Leu Thr 
            260                 265                 270         


Glu Ala Gln Ala Glu Gln Val Ile His Glu Ser Asp Pro His Phe Ser 
        275                 280                 285             


Thr Asp Gln Ala Arg Met Lys Lys Ser Ile Leu Gln Arg Ile Tyr Arg 
    290                 295                 300                 


Leu Leu Asn Gln Ile Gly Val Leu Glu Leu Asp Ser Val Lys Asp Ala 
305                 310                 315                 320 


Phe Ser Asp Arg Asn Tyr Val Thr Thr Gly Gly Gly Ser His His His 
                325                 330                 335     


His His His 
            


<210>  8
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Ser Ser Asp Thr Ile Asp Asn Val Lys Ser Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Leu Phe Val Gln 
65                  70                  75                  80  


Glu Leu Ala Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
                85                  90                  95      


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg 
            100                 105                 110         


Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe 
        115                 120                 125             


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    130                 135                 140                 


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
145                 150                 155                 160 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                165                 170                 175     


Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala 
            180                 185                 190         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        195                 200                 205             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
    210                 215                 220                 


Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys 
225                 230                 235                 240 


Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly 
                245                 250                 255     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            260                 265                 270         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val 
        275                 280                 285             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
    290                 295                 300                 


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
305                 310                 315                 320 


Leu Glu His His His His His His 
                325             


<210>  9
<211>  397
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Phe Gln Lys Val Asp Ala Tyr Ala Gly Asp Pro Ile Leu Thr Leu 
1               5                   10                  15      


Met Glu Arg Phe Lys Glu Asp Pro Arg Ser Asp Lys Val Asn Leu Ser 
            20                  25                  30          


Ile Gly Leu Tyr Tyr Asn Glu Asp Gly Ile Ile Pro Gln Leu Gln Ala 
        35                  40                  45              


Val Ala Glu Ala Glu Ala Arg Leu Asn Ala Gln Pro His Gly Ala Ser 
    50                  55                  60                  


Leu Tyr Leu Pro Met Glu Gly Leu Asn Cys Tyr Arg His Ala Ile Ala 
65                  70                  75                  80  


Pro Leu Leu Phe Gly Ala Asp His Pro Val Leu Lys Gln Gln Arg Val 
                85                  90                  95      


Ala Thr Ile Gln Thr Leu Gly Gly Ser Gly Ala Leu Lys Val Gly Ala 
            100                 105                 110         


Asp Phe Leu Lys Arg Tyr Phe Pro Glu Ser Gly Val Trp Val Ser Asp 
        115                 120                 125             


Pro Thr Trp Glu Asn His Val Ala Ile Phe Ala Gly Ala Gly Phe Glu 
    130                 135                 140                 


Val Ser Thr Tyr Pro Trp Tyr Asp Glu Ala Thr Asn Gly Val Arg Phe 
145                 150                 155                 160 


Asn Asp Leu Leu Ala Thr Leu Lys Thr Leu Pro Ala Arg Ser Ile Val 
                165                 170                 175     


Leu Leu His Pro Cys Cys His Asn Pro Thr Gly Ala Asp Leu Thr Asn 
            180                 185                 190         


Asp Gln Trp Asp Ala Val Ile Glu Ile Leu Lys Ala Arg Glu Leu Ile 
        195                 200                 205             


Pro Phe Leu Asp Ile Ala Tyr Gln Gly Phe Gly Ala Gly Met Glu Glu 
    210                 215                 220                 


Asp Ala Tyr Ala Ile Arg Ala Ile Ala Ser Ala Gly Leu Pro Ala Leu 
225                 230                 235                 240 


Val Ser Asn Ser Phe Ser Lys Ile Phe Ser Leu Tyr Gly Glu Arg Val 
                245                 250                 255     


Gly Gly Leu Ser Val Met Cys Glu Asp Ala Glu Ala Ala Gly Arg Val 
            260                 265                 270         


Leu Gly Gln Leu Lys Ala Thr Val Arg Arg Asn Tyr Ser Ser Pro Pro 
        275                 280                 285             


Asn Phe Gly Ala Gln Val Val Ala Ala Val Leu Asn Asp Glu Ala Leu 
    290                 295                 300                 


Lys Ala Ser Trp Leu Ala Glu Val Glu Glu Met Arg Thr Arg Ile Leu 
305                 310                 315                 320 


Ala Met Arg Gln Glu Leu Val Lys Val Leu Ser Thr Glu Met Pro Glu 
                325                 330                 335     


Arg Asn Phe Asp Tyr Leu Leu Asn Gln Arg Gly Met Phe Ser Tyr Thr 
            340                 345                 350         


Gly Leu Ser Ala Ala Gln Val Asp Arg Leu Arg Glu Glu Phe Gly Val 
        355                 360                 365             


Tyr Leu Ile Ala Ser Gly Arg Met Cys Val Ala Gly Leu Asn Thr Ala 
    370                 375                 380                 


Asn Val Gln Arg Val Ala Lys Ala Phe Ala Ala Val Met 
385                 390                 395         


<210>  10
<211>  396
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Phe Glu Asn Ile Thr Ala Ala Pro Ala Asp Pro Ile Leu Gly Leu 
1               5                   10                  15      


Ala Asp Leu Phe Arg Ala Asp Glu Arg Pro Gly Lys Ile Asn Leu Gly 
            20                  25                  30          


Ile Gly Val Tyr Lys Asp Glu Thr Gly Lys Thr Pro Val Leu Thr Ser 
        35                  40                  45              


Val Lys Lys Ala Glu Gln Tyr Leu Leu Glu Asn Glu Thr Thr Lys Asn 
    50                  55                  60                  


Tyr Leu Gly Ile Asp Gly Ile Pro Glu Phe Gly Arg Cys Thr Gln Glu 
65                  70                  75                  80  


Leu Leu Phe Gly Lys Gly Ser Ala Leu Ile Asn Asp Lys Arg Ala Arg 
                85                  90                  95      


Thr Ala Gln Thr Pro Gly Gly Thr Gly Ala Leu Arg Val Ala Ala Asp 
            100                 105                 110         


Phe Leu Ala Lys Asn Thr Ser Val Lys Arg Val Trp Val Ser Asn Pro 
        115                 120                 125             


Ser Trp Pro Asn His Lys Ser Val Phe Asn Ser Ala Gly Leu Glu Val 
    130                 135                 140                 


Arg Glu Tyr Ala Tyr Tyr Asp Ala Glu Asn His Thr Leu Asp Phe Asp 
145                 150                 155                 160 


Ala Leu Ile Asn Ser Leu Asn Glu Ala Gln Ala Gly Asp Val Val Leu 
                165                 170                 175     


Phe His Gly Cys Cys His Asn Pro Thr Gly Ile Asp Pro Thr Leu Glu 
            180                 185                 190         


Gln Trp Gln Thr Leu Ala Gln Leu Ser Val Glu Lys Gly Trp Leu Pro 
        195                 200                 205             


Leu Phe Asp Phe Ala Tyr Gln Gly Phe Ala Arg Gly Leu Glu Glu Asp 
    210                 215                 220                 


Ala Glu Gly Leu Arg Ala Phe Ala Ala Met His Lys Glu Leu Ile Val 
225                 230                 235                 240 


Ala Ser Ser Tyr Ser Lys Asn Phe Gly Leu Tyr Asn Glu Arg Val Gly 
                245                 250                 255     


Ala Cys Thr Leu Val Ala Ala Asp Ser Glu Thr Val Asp Arg Ala Phe 
            260                 265                 270         


Ser Gln Met Lys Ala Ala Ile Arg Ala Asn Tyr Ser Asn Pro Pro Ala 
        275                 280                 285             


His Gly Ala Ser Val Val Ala Thr Ile Leu Ser Asn Asp Ala Leu Arg 
    290                 295                 300                 


Ala Ile Trp Glu Gln Glu Leu Thr Asp Met Arg Gln Arg Ile Gln Arg 
305                 310                 315                 320 


Met Arg Gln Leu Phe Val Asn Thr Leu Gln Glu Lys Gly Ala Asn Arg 
                325                 330                 335     


Asp Phe Ser Phe Ile Ile Lys Gln Asn Gly Met Phe Ser Phe Ser Gly 
            340                 345                 350         


Leu Thr Lys Glu Gln Val Leu Arg Leu Arg Glu Glu Phe Gly Val Tyr 
        355                 360                 365             


Ala Val Ala Ser Gly Arg Val Asn Val Ala Gly Met Thr Pro Asp Asn 
    370                 375                 380                 


Met Ala Pro Leu Cys Glu Ala Ile Val Ala Val Leu 
385                 390                 395     


<210>  11
<211>  309
<212>  PRT
<213>  Escherichia coli

<400>  11

Met Thr Thr Lys Lys Ala Asp Tyr Ile Trp Phe Asn Gly Glu Met Val 
1               5                   10                  15      


Arg Trp Glu Asp Ala Lys Val His Val Met Ser His Ala Leu His Tyr 
            20                  25                  30          


Gly Thr Ser Val Phe Glu Gly Ile Arg Cys Tyr Asp Ser His Lys Gly 
        35                  40                  45              


Pro Val Val Phe Arg His Arg Glu His Met Gln Arg Leu His Asp Ser 
    50                  55                  60                  


Ala Lys Ile Tyr Arg Phe Pro Val Ser Gln Ser Ile Asp Glu Leu Met 
65                  70                  75                  80  


Glu Ala Cys Arg Asp Val Ile Arg Lys Asn Asn Leu Thr Ser Ala Tyr 
                85                  90                  95      


Ile Arg Pro Leu Ile Phe Val Gly Asp Val Gly Met Gly Val Asn Pro 
            100                 105                 110         


Pro Ala Gly Tyr Ser Thr Asp Val Ile Ile Ala Ala Phe Pro Trp Gly 
        115                 120                 125             


Ala Tyr Leu Gly Ala Glu Ala Leu Glu Gln Gly Ile Asp Ala Met Val 
    130                 135                 140                 


Ser Ser Trp Asn Arg Ala Ala Pro Asn Thr Ile Pro Thr Ala Ala Lys 
145                 150                 155                 160 


Ala Gly Gly Asn Tyr Leu Ser Ser Leu Leu Val Gly Ser Glu Ala Arg 
                165                 170                 175     


Arg His Gly Tyr Gln Glu Gly Ile Ala Leu Asp Val Asn Gly Tyr Ile 
            180                 185                 190         


Ser Glu Gly Ala Gly Glu Asn Leu Phe Glu Val Lys Asp Gly Val Leu 
        195                 200                 205             


Phe Thr Pro Pro Phe Thr Ser Ser Ala Leu Pro Gly Ile Thr Arg Asp 
    210                 215                 220                 


Ala Ile Ile Lys Leu Ala Lys Glu Leu Gly Ile Glu Val Arg Glu Gln 
225                 230                 235                 240 


Val Leu Ser Arg Glu Ser Leu Tyr Leu Ala Asp Glu Val Phe Met Ser 
                245                 250                 255     


Gly Thr Ala Ala Glu Ile Thr Pro Val Arg Ser Val Asp Gly Ile Gln 
            260                 265                 270         


Val Gly Glu Gly Arg Cys Gly Pro Val Thr Lys Arg Ile Gln Gln Ala 
        275                 280                 285             


Phe Phe Gly Leu Phe Thr Gly Glu Thr Glu Asp Lys Trp Gly Trp Leu 
    290                 295                 300                 


Asp Gln Val Asn Gln 
305                 


<210>  12
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Tyr 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Asp Ile His 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  13
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Ser Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Leu Asn 
145                 150                 155                 160 


Tyr Glu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  14
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Thr 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Thr Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Leu His 
145                 150                 155                 160 


Tyr Ala Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  15
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Ala His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Val Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  16
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Val Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Asp His Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Ile His 
145                 150                 155                 160 


Tyr Ser Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  17
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Val Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Trp Met Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Ala His 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


