                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado, a body corporate
 
<120>  PAPD5 INHIBITION AS A TREATMENT FOR DYSKERATOSIS CONGENITA, 
       APLASTIC ANEMIA AND MYELODYSPLASTIC SYNDROME CAUSED BY REDUCED 
       TELOMERASE RNA LEVELS

<130>  90245.00421

<150>  62/932,191
<151>  2019-11-07

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  572
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Tyr Arg Ser Gly Glu Arg Leu Leu Gly Ser His Ala Leu Pro Ala 
1               5                   10                  15      


Glu Gln Arg Asp Phe Leu Pro Leu Glu Thr Thr Asn Asn Asn Asn Asn 
            20                  25                  30          


His His Gln Pro Gly Ala Trp Ala Arg Arg Ala Gly Ser Ser Ala Ser 
        35                  40                  45              


Ser Pro Pro Ser Ala Ser Ser Ser Pro His Pro Ser Ala Ala Val Pro 
    50                  55                  60                  


Ala Ala Asp Pro Ala Asp Ser Ala Ser Gly Ser Ser Asn Lys Arg Lys 
65                  70                  75                  80  


Arg Asp Asn Lys Ala Ser Gly Gly Arg Ala Ala Gly Gly Gly Arg Ala 
                85                  90                  95      


Asp Gly Gly Gly Val Val Tyr Ser Gly Thr Pro Trp Lys Arg Arg Asn 
            100                 105                 110         


Tyr Asn Gln Gly Val Val Gly Leu His Glu Glu Ile Ser Asp Phe Tyr 
        115                 120                 125             


Glu Tyr Met Ser Pro Arg Pro Glu Glu Glu Lys Met Arg Met Glu Val 
    130                 135                 140                 


Val Asn Arg Ile Glu Ser Val Ile Lys Glu Leu Trp Pro Ser Ala Asp 
145                 150                 155                 160 


Val Gln Ile Phe Gly Ser Phe Lys Thr Gly Leu Tyr Leu Pro Thr Ser 
                165                 170                 175     


Asp Ile Asp Leu Val Val Phe Gly Lys Trp Glu Asn Leu Pro Leu Trp 
            180                 185                 190         


Thr Leu Glu Glu Ala Leu Arg Lys His Lys Val Ala Asp Glu Asp Ser 
        195                 200                 205             


Val Lys Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp 
    210                 215                 220                 


Ser Phe Thr Glu Val Lys Val Asp Ile Ser Phe Asn Val Gln Asn Gly 
225                 230                 235                 240 


Val Arg Ala Ala Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr Pro Val 
                245                 250                 255     


Leu Pro Tyr Leu Val Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp 
            260                 265                 270         


Leu Asn Glu Val Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu Phe Leu 
        275                 280                 285             


Met Ala Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile 
    290                 295                 300                 


Pro Asn Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr 
305                 310                 315                 320 


Gly Arg His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly 
                325                 330                 335     


Gly Ser Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly 
            340                 345                 350         


Tyr Arg Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn 
        355                 360                 365             


Asp Val Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe 
    370                 375                 380                 


Asp Tyr Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys 
385                 390                 395                 400 


Tyr Tyr Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg 
                405                 410                 415     


Val Thr Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp 
            420                 425                 430         


Gly Leu Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Pro Val Ser Ser 
        435                 440                 445             


Ser Ser Ala Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr 
    450                 455                 460                 


Pro Cys Lys Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn 
465                 470                 475                 480 


Arg Val Gly Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly 
                485                 490                 495     


Lys Met Gln Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys 
            500                 505                 510         


Ser Gln His Gly Ser Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly Phe 
        515                 520                 525             


Gln Gly Thr Thr Gln Thr Ser His Gly Ser Leu Met Thr Asn Lys Gln 
    530                 535                 540                 


His Gln Gly Lys Ser Asn Asn Gln Tyr Tyr His Gly Lys Lys Arg Lys 
545                 550                 555                 560 


His Lys Arg Asp Ala Pro Leu Ser Asp Leu Cys Arg 
                565                 570         


<210>  2
<211>  451
<212>  DNA
<213>  Homo Sapiens

<400>  2
gggttgcgga gggtgggcct gggaggggtg gtggccattt tttgtctaac cctaactgag       60

aagggcgtag gcgccgtgct tttgctcccc gcgcgctgtt tttctcgctg actttcagcg      120

ggcggaaaag cctcggcctg ccgccttcca ccgttcattc tagagcaaac aaaaaatgtc      180

agctgctggc ccgttcgccc ctcccgggga cctgcggcgg gtcgcctgcc cagcccccga      240

accccgcctg gaggccgcgg tcggcccggg gcttctccgg aggcacccac tgccaccgcg      300

aagagttggg ctctgtcagc cgcgggtctc tcgggggcga gggcgaggtt caggcctttc      360

aggccgcagg aagaggaacg gagcgagtcc ccgcgcgcgg cgcgattccc tgagctgtgg      420

gacgtgcacc caggactcgg ctcacacatg c                                     451


