                               SEQUENCE LISTING

<110> THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
 
<120> HIGH CONCENTRATION CELL PENETRATING CASPASE INHIBITOR CONJUGATES
      COMPOSITIONS AND METHODS THEREOF

<130> 070050.6433

<140> PCT/US2020/058683
<141> 2020-11-03

<150> 62/930,371
<151> 2019-11-04

<160> 61    

<170> PatentIn version 3.5

<210> 1
<211> 300
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase-6 sequence

<400> 1
Met Ala Ser Ser Ala Ser Gly Leu Arg Arg Gly His Pro Ala Gly Gly 
1               5                   10                  15      


Glu Glu Asn Met Thr Glu Thr Asp Ala Phe Tyr Lys Arg Glu Met Phe 
            20                  25                  30          


Asp Pro Ala Glu Lys Tyr Lys Met Asp His Arg Arg Arg Gly Ile Ala 
        35                  40                  45              


Leu Ile Phe Asn His Glu Arg Phe Phe Trp His Leu Thr Leu Pro Glu 
    50                  55                  60                  


Arg Arg Gly Thr Cys Ala Asp Arg Asp Asn Leu Thr Arg Arg Phe Ser 
65                  70                  75                  80  


Asp Leu Gly Phe Glu Val Lys Cys Phe Asn Asp Leu Lys Ala Glu Glu 
                85                  90                  95      


Leu Leu Leu Lys Ile His Glu Val Ser Thr Val Ser His Ala Asp Ala 
            100                 105                 110         


Asp Cys Phe Val Cys Val Phe Leu Ser His Gly Glu Gly Asn His Ile 
        115                 120                 125             


Tyr Ala Tyr Asp Ala Lys Ile Glu Ile Gln Thr Leu Thr Gly Leu Phe 
    130                 135                 140                 


Lys Gly Asp Lys Cys His Ser Leu Val Gly Lys Pro Lys Ile Phe Ile 
145                 150                 155                 160 


Ile Gln Ala Ala Arg Gly Asn Gln His Asp Val Pro Val Ile Pro Leu 
                165                 170                 175     


Asp Val Val Asp Asn Gln Thr Glu Lys Leu Asp Thr Asn Ile Thr Glu 
            180                 185                 190         


Val Asp Ala Ala Ser Val Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu 
        195                 200                 205             


Met Cys Tyr Ser Val Ala Glu Gly Tyr Tyr Ser His Arg Glu Thr Val 
    210                 215                 220                 


Asn Gly Ser Trp Tyr Ile Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr 
225                 230                 235                 240 


Gly Ser Ser Leu Glu Phe Thr Glu Leu Leu Thr Leu Val Asn Arg Lys 
                245                 250                 255     


Val Ser Gln Arg Arg Val Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly 
            260                 265                 270         


Lys Lys Gln Val Pro Cys Phe Ala Ser Met Leu Thr Lys Lys Leu His 
        275                 280                 285             


Phe Phe Pro Lys Ser Asn Leu Glu His His His His 
    290                 295                 300 


<210> 2
<211> 95
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      XBIR3 sequence

<400> 2
Ser Thr Asn Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg 
1               5                   10                  15      


Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu 
            20                  25                  30          


Ala Arg Ala Gly Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys 
        35                  40                  45              


Phe His Cys Gly Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro 
    50                  55                  60                  


Trp Glu Gln His Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu 
65                  70                  75                  80  


Gln Lys Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
                85                  90                  95  


<210> 3
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Thr Asn Thr Cys Leu Pro Arg Asn Pro Ser 
            20                  25                  30          


Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr 
        35                  40                  45              


Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp 
    50                  55                  60                  


Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly 
65                  70                  75                  80  


Leu Arg Pro Ser Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro 
                85                  90                  95      


Gly Cys Arg Tyr Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn 
            100                 105                 110         


Ile His Leu Thr His Ser 
        115             


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 4
His His His His His His 
1               5       


<210> 5
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Thr Asn Thr Leu Pro Arg Asn Pro Ser Met 
            20                  25                  30          


Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser 
        35                  40                  45              


Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Thr Asp Trp Ala 
    50                  55                  60                  


Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly Gly Gly Leu 
65                  70                  75                  80  


Arg Pro Ser Glu Asp Pro Trp Glu Gln His Ala Arg Trp Tyr Pro Gly 
                85                  90                  95      


Cys Arg Tyr Leu Leu Glu Gln Arg Gly Gln Glu Tyr Ile Asn Asn Ile 
            100                 105                 110         


His Leu Thr His Ser 
        115         


<210> 6
<211> 68
<212> PRT
<213> Homo sapiens

<400> 6
Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr Ala His 
1               5                   10                  15      


Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr Gly Ile 
            20                  25                  30          


Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys Asn Trp 
        35                  40                  45              


Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe Pro Asn 
    50                  55                  60                  


Cys Phe Phe Val 
65              


<210> 7
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 7
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Arg Arg Leu Arg Arg Leu Leu Arg Arg Leu Leu Arg Arg Leu Arg Arg 
1               5                   10                  15      


<210> 9
<211> 12
<212> PRT
<213> Rabies lyssavirus

<400> 9
Arg Val Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          


<210> 10
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210> 11
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      pIsl sequence

<400> 11
Pro Val Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys 
1               5                   10                  15      


<210> 12
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 12
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 13
<211> 16
<212> PRT
<213> Mus sp.

<400> 13
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


<210> 14
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MPS sequence

<400> 14
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 15
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Val Lys Arg Gly Leu Lys Leu Arg His Val Arg Pro Arg Val Thr Arg 
1               5                   10                  15      


Met Asp Val 
            


<210> 16
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      M918 sequence

<400> 16
Met Val Thr Val Leu Phe Arg Arg Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210> 17
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      M1073 sequence

<400> 17
Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210> 18
<211> 28
<212> PRT
<213> Bos sp.

<400> 18
Met Val Lys Ser Lys Ile Gly Ser Trp Ile Leu Val Leu Phe Val Ala 
1               5                   10                  15      


Met Trp Ser Asp Val Gly Leu Cys Lys Lys Arg Pro 
            20                  25              


<210> 19
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 20
<211> 6
<212> PRT
<213> Simian virus 40

<400> 20
Lys Lys Lys Arg Lys Val 
1               5       


<210> 21
<211> 17
<212> PRT
<213> Human immunodeficiency virus

<400> 21
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala 
    


<210> 22
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210> 23
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp 
1               5                   10          


<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 25
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Leu Lys Thr Leu Thr Glu Thr Leu Lys Glu Leu Thr Lys Thr Leu Thr 
1               5                   10                  15      


Glu Leu 
        


<210> 26
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Gln Leu Ala Leu Gln Leu Ala Leu Gln Ala Leu Gln Ala Ala Leu Gln 
1               5                   10                  15      


Leu Ala 
        


<210> 27
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Trp Glu Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu His 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala 
            20                  25                  30  


<210> 28
<211> 28
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      p28 sequence

<400> 28
Leu Ser Thr Ala Ala Asp Met Gln Gly Val Val Thr Asp Gly Met Ala 
1               5                   10                  15      


Ser Gly Leu Asp Lys Asp Tyr Leu Lys Pro Asp Asp 
            20                  25              


<210> 29
<211> 12
<212> PRT
<213> Hepatitis B virus

<400> 29
Pro Leu Ser Ser Ile Phe Ser Arg Ile Gly Asp Pro 
1               5                   10          


<210> 30
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Lys Pro Asp 
            20                  25      


<210> 31
<211> 24
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Bactenecin-7 sequence

<400> 31
Arg Arg Ile Arg Pro Arg Pro Pro Arg Leu Pro Arg Pro Arg Pro Arg 
1               5                   10                  15      


Pro Leu Pro Phe Pro Arg Pro Gly 
            20                  


<210> 32
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      SAP sequence

<400> 32
Val Arg Leu Pro Pro Pro Val Arg Leu Pro Pro Pro Val Arg Leu Pro 
1               5                   10                  15      


Pro Pro 
        


<210> 33
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Val Glu Leu Pro Pro Pro Val Glu Leu Pro Pro Pro Val Glu Leu Pro 
1               5                   10                  15      


Pro Pro 
        


<210> 34
<211> 10
<212> PRT
<213> Crotalus durissus

<400> 34
Cys Arg Trp Arg Trp Lys Cys Cys Lys Lys 
1               5                   10  


<210> 35
<211> 20
<212> PRT
<213> Herpes simplex virus 1

<400> 35
His Gly Leu Ala Ser Thr Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
1               5                   10                  15      


Ile Arg Ala Phe 
            20  


<210> 36
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      FGF12 sequence

<400> 36
Pro Ile Glu Val Cys Met Tyr Arg Glu Pro 
1               5                   10  


<210> 37
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Cys Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Tyr Leu 
1               5                   10                  15      


Ile 
    


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210> 39
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Arg Leu Ser Gly Met Asn Glu Val Leu Ser Phe Arg Trp 
1               5                   10              


<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Cys(NPys)

<400> 40
Cys Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys 
    


<210> 41

<400> 41
000


<210> 42

<400> 42
000


<210> 43

<400> 43
000


<210> 44

<400> 44
000


<210> 45
<211> 618
<212> PRT
<213> Homo sapiens

<400> 45
Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His 
            180                 185                 190         


Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg 
            260                 265                 270         


Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    610                 615             


<210> 46
<211> 604
<212> PRT
<213> Homo sapiens

<400> 46
Met Asn Ile Val Glu Asn Ser Ile Phe Leu Ser Asn Leu Met Lys Ser 
1               5                   10                  15      


Ala Asn Thr Phe Glu Leu Lys Tyr Asp Leu Ser Cys Glu Leu Tyr Arg 
            20                  25                  30          


Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
        35                  40                  45              


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys Val 
    50                  55                  60                  


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Thr Glu Lys His Lys Lys Leu Tyr Pro Ser Cys Arg Phe Val 
                85                  90                  95      


Gln Ser Leu Asn Ser Val Asn Asn Leu Glu Ala Thr Ser Gln Pro Thr 
            100                 105                 110         


Phe Pro Ser Ser Val Thr Asn Ser Thr His Ser Leu Leu Pro Gly Thr 
        115                 120                 125             


Glu Asn Ser Gly Tyr Phe Arg Gly Ser Tyr Ser Asn Ser Pro Ser Asn 
    130                 135                 140                 


Pro Val Asn Ser Arg Ala Asn Gln Asp Phe Ser Ala Leu Met Arg Ser 
145                 150                 155                 160 


Ser Tyr His Cys Ala Met Asn Asn Glu Asn Ala Arg Leu Leu Thr Phe 
                165                 170                 175     


Gln Thr Trp Pro Leu Thr Phe Leu Ser Pro Thr Asp Leu Ala Lys Ala 
            180                 185                 190         


Gly Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys 
        195                 200                 205             


Gly Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asn Ala Met Ser Glu 
    210                 215                 220                 


His Leu Arg His Phe Pro Lys Cys Pro Phe Ile Glu Asn Gln Leu Gln 
225                 230                 235                 240 


Asp Thr Ser Arg Tyr Thr Val Ser Asn Leu Ser Met Gln Thr His Ala 
                245                 250                 255     


Ala Arg Phe Lys Thr Phe Phe Asn Trp Pro Ser Ser Val Leu Val Asn 
            260                 265                 270         


Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Asn Ser Asp 
        275                 280                 285             


Asp Val Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser 
    290                 295                 300                 


Gly Asp Asp Pro Trp Val Gln His Ala Lys Trp Phe Pro Arg Cys Glu 
305                 310                 315                 320 


Tyr Leu Ile Arg Ile Lys Gly Gln Glu Phe Ile Arg Gln Val Gln Ala 
                325                 330                 335     


Ser Tyr Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Ser Pro 
            340                 345                 350         


Gly Asp Glu Asn Ala Glu Ser Ser Ile Ile His Phe Glu Pro Gly Glu 
        355                 360                 365             


Asp His Ser Glu Asp Ala Ile Met Met Asn Thr Pro Val Ile Asn Ala 
    370                 375                 380                 


Ala Val Glu Met Gly Phe Ser Arg Ser Leu Val Lys Gln Thr Val Gln 
385                 390                 395                 400 


Arg Lys Ile Leu Ala Thr Gly Glu Asn Tyr Arg Leu Val Asn Asp Leu 
                405                 410                 415     


Val Leu Asp Leu Leu Asn Ala Glu Asp Glu Ile Arg Glu Glu Glu Arg 
            420                 425                 430         


Glu Arg Ala Thr Glu Glu Lys Glu Ser Asn Asp Leu Leu Leu Ile Arg 
        435                 440                 445             


Lys Asn Arg Met Ala Leu Phe Gln His Leu Thr Cys Val Ile Pro Ile 
    450                 455                 460                 


Leu Asp Ser Leu Leu Thr Ala Gly Ile Ile Asn Glu Gln Glu His Asp 
465                 470                 475                 480 


Val Ile Lys Gln Lys Thr Gln Thr Ser Leu Gln Ala Arg Glu Leu Ile 
                485                 490                 495     


Asp Thr Ile Leu Val Lys Gly Asn Ile Ala Ala Thr Val Phe Arg Asn 
            500                 505                 510         


Ser Leu Gln Glu Ala Glu Ala Val Leu Tyr Glu His Leu Phe Val Gln 
        515                 520                 525             


Gln Asp Ile Lys Tyr Ile Pro Thr Glu Asp Val Ser Asp Leu Pro Val 
    530                 535                 540                 


Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys 
545                 550                 555                 560 


Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro Cys Gly His Leu Val 
                565                 570                 575     


Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg 
            580                 585                 590         


Ser Thr Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
        595                 600                 


<210> 47
<211> 497
<212> PRT
<213> Homo sapiens

<400> 47
Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210> 48
<211> 1403
<212> PRT
<213> Homo sapiens

<400> 48
Met Ala Thr Gln Gln Lys Ala Ser Asp Glu Arg Ile Ser Gln Phe Asp 
1               5                   10                  15      


His Asn Leu Leu Pro Glu Leu Ser Ala Leu Leu Gly Leu Asp Ala Val 
            20                  25                  30          


Gln Leu Ala Lys Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg Ala Lys 
        35                  40                  45              


Met Gln Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu Ala Lys Arg Leu 
    50                  55                  60                  


Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser Ser Trp Ile Pro Gln Glu 
65                  70                  75                  80  


Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly Ile Gln 
                85                  90                  95      


Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly Leu Thr Arg Leu 
            100                 105                 110         


Pro Ile Glu Asp His Lys Arg Phe His Pro Asp Cys Gly Phe Leu Leu 
        115                 120                 125             


Asn Lys Asp Val Gly Asn Ile Ala Lys Tyr Asp Ile Arg Val Lys Asn 
    130                 135                 140                 


Leu Lys Ser Arg Leu Arg Gly Gly Lys Met Arg Tyr Gln Glu Glu Glu 
145                 150                 155                 160 


Ala Arg Leu Ala Ser Phe Arg Asn Trp Pro Phe Tyr Val Gln Gly Ile 
                165                 170                 175     


Ser Pro Cys Val Leu Ser Glu Ala Gly Phe Val Phe Thr Gly Lys Gln 
            180                 185                 190         


Asp Thr Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Gly Asn Trp Glu 
        195                 200                 205             


Glu Gly Asp Asp Pro Trp Lys Glu His Ala Lys Trp Phe Pro Lys Cys 
    210                 215                 220                 


Glu Phe Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile 
225                 230                 235                 240 


Gln Ser Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn 
                245                 250                 255     


Ser Trp Val Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp 
            260                 265                 270         


Ser Ile Phe Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp 
        275                 280                 285             


Pro Arg Glu Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu 
    290                 295                 300                 


Phe Tyr Thr Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly 
305                 310                 315                 320 


Cys Leu Glu Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr 
                325                 330                 335     


Arg Cys Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala 
            340                 345                 350         


Glu Val Thr Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu 
        355                 360                 365             


Glu Thr Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro 
    370                 375                 380                 


Ile Val Pro Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala 
385                 390                 395                 400 


Lys Asn Leu Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe 
                405                 410                 415     


Arg His Met Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His 
            420                 425                 430         


Leu Leu Gly Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro 
        435                 440                 445             


Val Gln Glu Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser 
    450                 455                 460                 


Val Met Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu 
465                 470                 475                 480 


Lys Lys Ile Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn 
                485                 490                 495     


Arg Phe Gln Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp 
            500                 505                 510         


Glu Gly Leu Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly 
        515                 520                 525             


Ser Val Thr Glu Met Cys Val Arg Asn Ile Ile Gln Gln Leu Lys Asn 
    530                 535                 540                 


Gln Val Leu Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro 
545                 550                 555                 560 


Gln Val Ile Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys 
                565                 570                 575     


Leu Leu Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr 
            580                 585                 590         


Leu Glu Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val 
        595                 600                 605             


Cys Ile Leu Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys 
    610                 615                 620                 


Phe Met Val Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys 
625                 630                 635                 640 


Thr Pro Leu Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro 
                645                 650                 655     


Phe Asp Pro Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu 
            660                 665                 670         


Arg Leu Ser Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr 
        675                 680                 685             


Val Ser Ser Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys 
    690                 695                 700                 


Phe Glu Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp 
705                 710                 715                 720 


Glu Asp Leu Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu 
                725                 730                 735     


Arg Pro Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala 
            740                 745                 750         


Gly Met Arg Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln 
        755                 760                 765             


Asp Leu Gly Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met Thr 
    770                 775                 780                 


Val Ser Ala Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser 
785                 790                 795                 800 


Thr Lys Ala Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp 
                805                 810                 815     


Asn Lys Glu Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys 
            820                 825                 830         


His Gln Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp 
        835                 840                 845             


Gln Ile Cys Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu 
    850                 855                 860                 


Val Leu Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys 
865                 870                 875                 880 


Ser Pro Phe Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly 
                885                 890                 895     


Ala Leu Asn Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu 
            900                 905                 910         


Leu Arg Ser Ile His Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg 
        915                 920                 925             


Ala His Phe Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro 
    930                 935                 940                 


Thr Ile Asp Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp 
945                 950                 955                 960 


Glu Arg Asn Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp 
                965                 970                 975     


Met Gln Arg Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu 
            980                 985                 990         


Ser Pro Lys Gln Tyr Lys Ile Pro  Cys Leu Glu Val Asp  Val Asn Asp 
        995                 1000                 1005             


Ile Asp  Val Val Gly Gln Asp  Met Leu Glu Ile Leu  Met Thr Val 
    1010                 1015                 1020             


Phe Ser  Ala Ser Gln Arg Ile  Glu Leu His Leu Asn  His Ser Arg 
    1025                 1030                 1035             


Gly Phe  Ile Glu Ser Ile Arg  Pro Ala Leu Glu Leu  Ser Lys Ala 
    1040                 1045                 1050             


Ser Val  Thr Lys Cys Ser Ile  Ser Lys Leu Glu Leu  Ser Ala Ala 
    1055                 1060                 1065             


Glu Gln  Glu Leu Leu Leu Thr  Leu Pro Ser Leu Glu  Ser Leu Glu 
    1070                 1075                 1080             


Val Ser  Gly Thr Ile Gln Ser  Gln Asp Gln Ile Phe  Pro Asn Leu 
    1085                 1090                 1095             


Asp Lys  Phe Leu Cys Leu Lys  Glu Leu Ser Val Asp  Leu Glu Gly 
    1100                 1105                 1110             


Asn Ile  Asn Val Phe Ser Val  Ile Pro Glu Glu Phe  Pro Asn Phe 
    1115                 1120                 1125             


His His  Met Glu Lys Leu Leu  Ile Gln Ile Ser Ala  Glu Tyr Asp 
    1130                 1135                 1140             


Pro Ser  Lys Leu Val Lys Leu  Ile Gln Asn Ser Pro  Asn Leu His 
    1145                 1150                 1155             


Val Phe  His Leu Lys Cys Asn  Phe Phe Ser Asp Phe  Gly Ser Leu 
    1160                 1165                 1170             


Met Thr  Met Leu Val Ser Cys  Lys Lys Leu Thr Glu  Ile Lys Phe 
    1175                 1180                 1185             


Ser Asp  Ser Phe Phe Gln Ala  Val Pro Phe Val Ala  Ser Leu Pro 
    1190                 1195                 1200             


Asn Phe  Ile Ser Leu Lys Ile  Leu Asn Leu Glu Gly  Gln Gln Phe 
    1205                 1210                 1215             


Pro Asp  Glu Glu Thr Ser Glu  Lys Phe Ala Tyr Ile  Leu Gly Ser 
    1220                 1225                 1230             


Leu Ser  Asn Leu Glu Glu Leu  Ile Leu Pro Thr Gly  Asp Gly Ile 
    1235                 1240                 1245             


Tyr Arg  Val Ala Lys Leu Ile  Ile Gln Gln Cys Gln  Gln Leu His 
    1250                 1255                 1260             


Cys Leu  Arg Val Leu Ser Phe  Phe Lys Thr Leu Asn  Asp Asp Ser 
    1265                 1270                 1275             


Val Val  Glu Ile Ala Lys Val  Ala Ile Ser Gly Gly  Phe Gln Lys 
    1280                 1285                 1290             


Leu Glu  Asn Leu Lys Leu Ser  Ile Asn His Lys Ile  Thr Glu Glu 
    1295                 1300                 1305             


Gly Tyr  Arg Asn Phe Phe Gln  Ala Leu Asp Asn Met  Pro Asn Leu 
    1310                 1315                 1320             


Gln Glu  Leu Asp Ile Ser Arg  His Phe Thr Glu Cys  Ile Lys Ala 
    1325                 1330                 1335             


Gln Ala  Thr Thr Val Lys Ser  Leu Ser Gln Cys Val  Leu Arg Leu 
    1340                 1345                 1350             


Pro Arg  Leu Ile Arg Leu Asn  Met Leu Ser Trp Leu  Leu Asp Ala 
    1355                 1360                 1365             


Asp Asp  Ile Ala Leu Leu Asn  Val Met Lys Glu Arg  His Pro Gln 
    1370                 1375                 1380             


Ser Lys  Tyr Leu Thr Ile Leu  Gln Lys Trp Ile Leu  Pro Phe Ser 
    1385                 1390                 1395             


Pro Ile  Ile Gln Lys 
    1400             


<210> 49
<211> 142
<212> PRT
<213> Homo sapiens

<400> 49
Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210> 50
<211> 1867
<212> PRT
<213> Homo sapiens

<400> 50
Met Ser Gln Ile Leu Ser Ala Leu Gly Leu Cys Asn Ser Ser Ala Met 
1               5                   10                  15      


Ala Met Ile Ile Gly Ala Ser Gly Leu His Leu Thr Lys His Glu Asn 
            20                  25                  30          


Phe His Gly Gly Leu Asp Ala Ile Ser Val Gly Asp Gly Leu Phe Thr 
        35                  40                  45              


Ile Leu Thr Thr Leu Ser Lys Lys Ala Ser Thr Val His Met Met Leu 
    50                  55                  60                  


Gln Pro Ile Leu Thr Tyr Met Ala Cys Gly Tyr Met Gly Arg Gln Gly 
65                  70                  75                  80  


Ser Leu Ala Thr Cys Gln Leu Ser Glu Pro Leu Leu Trp Phe Ile Leu 
                85                  90                  95      


Arg Val Leu Asp Thr Ser Asp Ala Leu Lys Ala Phe His Asp Met Gly 
            100                 105                 110         


Gly Val Gln Leu Ile Cys Asn Asn Met Val Thr Ser Thr Arg Ala Ile 
        115                 120                 125             


Val Asn Thr Ala Lys Ser Met Val Ser Thr Ile Met Lys Phe Leu Asp 
    130                 135                 140                 


Ser Gly Pro Asn Lys Ala Val Asp Ser Thr Leu Lys Thr Arg Ile Leu 
145                 150                 155                 160 


Ala Ser Glu Pro Asp Asn Ala Glu Gly Ile His Asn Phe Ala Pro Leu 
                165                 170                 175     


Gly Thr Ile Thr Ser Ser Ser Pro Thr Ala Gln Pro Ala Glu Val Leu 
            180                 185                 190         


Leu Gln Ala Thr Pro Pro His Arg Arg Ala Arg Ser Ala Ala Trp Ser 
        195                 200                 205             


Tyr Ile Phe Leu Pro Glu Glu Ala Trp Cys Asn Leu Thr Ile His Leu 
    210                 215                 220                 


Pro Ala Ala Val Leu Leu Lys Glu Ile His Ile Gln Pro His Leu Ala 
225                 230                 235                 240 


Ser Leu Ala Thr Cys Pro Ser Ser Val Ser Val Glu Val Ser Ala Asp 
                245                 250                 255     


Gly Val Asn Met Leu Pro Leu Ser Thr Pro Val Val Thr Ser Gly Leu 
            260                 265                 270         


Thr Tyr Ile Lys Ile Gln Leu Val Lys Ala Glu Val Ala Ser Ala Val 
        275                 280                 285             


Cys Leu Arg Leu His Arg Pro Arg Asp Ala Ser Thr Leu Gly Leu Ser 
    290                 295                 300                 


Gln Ile Lys Leu Leu Gly Leu Thr Ala Phe Gly Thr Thr Ser Ser Ala 
305                 310                 315                 320 


Thr Val Asn Asn Pro Phe Leu Pro Ser Glu Asp Gln Val Ser Lys Thr 
                325                 330                 335     


Ser Ile Gly Trp Leu Arg Leu Leu His His Cys Leu Thr His Ile Ser 
            340                 345                 350         


Asp Leu Glu Gly Met Met Ala Ser Ala Ala Ala Pro Thr Ala Asn Leu 
        355                 360                 365             


Leu Gln Thr Cys Ala Ala Leu Leu Met Ser Pro Tyr Cys Gly Met His 
    370                 375                 380                 


Ser Pro Asn Ile Glu Val Val Leu Val Lys Ile Gly Leu Gln Ser Thr 
385                 390                 395                 400 


Arg Ile Gly Leu Lys Leu Ile Asp Ile Leu Leu Arg Asn Cys Ala Ala 
                405                 410                 415     


Ser Gly Ser Asp Pro Thr Asp Leu Asn Ser Pro Leu Leu Phe Gly Arg 
            420                 425                 430         


Leu Asn Gly Leu Ser Ser Asp Ser Thr Ile Asp Ile Leu Tyr Gln Leu 
        435                 440                 445             


Gly Thr Ser Gln Asp Pro Gly Thr Lys Asp Arg Ile Gln Ala Leu Leu 
    450                 455                 460                 


Lys Trp Val Ser Asp Ser Ala Arg Val Ala Ala Met Lys Arg Ser Gly 
465                 470                 475                 480 


Arg Met Asn Tyr Met Cys Pro Asn Ser Ser Thr Val Glu Tyr Gly Leu 
                485                 490                 495     


Leu Met Pro Ser Pro Ser His Leu His Cys Val Ala Ala Ile Leu Trp 
            500                 505                 510         


His Ser Tyr Glu Leu Leu Val Glu Tyr Asp Leu Pro Ala Leu Leu Asp 
        515                 520                 525             


Gln Glu Leu Phe Glu Leu Leu Phe Asn Trp Ser Met Ser Leu Pro Cys 
    530                 535                 540                 


Asn Met Val Leu Lys Lys Ala Val Asp Ser Leu Leu Cys Ser Met Cys 
545                 550                 555                 560 


His Val His Pro Asn Tyr Phe Ser Leu Leu Met Gly Trp Met Gly Ile 
                565                 570                 575     


Thr Pro Pro Pro Val Gln Cys His His Arg Leu Ser Met Thr Asp Asp 
            580                 585                 590         


Ser Lys Lys Gln Asp Leu Ser Ser Ser Leu Thr Asp Asp Ser Lys Asn 
        595                 600                 605             


Ala Gln Ala Pro Leu Ala Leu Thr Glu Ser His Leu Ala Thr Leu Ala 
    610                 615                 620                 


Ser Ser Ser Gln Ser Pro Glu Ala Ile Lys Gln Leu Leu Asp Ser Gly 
625                 630                 635                 640 


Leu Pro Ser Leu Leu Val Arg Ser Leu Ala Ser Phe Cys Phe Ser His 
                645                 650                 655     


Ile Ser Ser Ser Glu Ser Ile Ala Gln Ser Ile Asp Ile Ser Gln Asp 
            660                 665                 670         


Lys Leu Arg Arg His His Val Pro Gln Gln Cys Asn Lys Met Pro Ile 
        675                 680                 685             


Thr Ala Asp Leu Val Ala Pro Ile Leu Arg Phe Leu Thr Glu Val Gly 
    690                 695                 700                 


Asn Ser His Ile Met Lys Asp Trp Leu Gly Gly Ser Glu Val Asn Pro 
705                 710                 715                 720 


Leu Trp Thr Ala Leu Leu Phe Leu Leu Cys His Ser Gly Ser Thr Ser 
                725                 730                 735     


Gly Ser His Asn Leu Gly Ala Gln Gln Thr Ser Ala Arg Ser Ala Ser 
            740                 745                 750         


Leu Ser Ser Ala Ala Thr Thr Gly Leu Thr Thr Gln Gln Arg Thr Ala 
        755                 760                 765             


Ile Glu Asn Ala Thr Val Ala Phe Phe Leu Gln Cys Ile Ser Cys His 
    770                 775                 780                 


Pro Asn Asn Gln Lys Leu Met Ala Gln Val Leu Cys Glu Leu Phe Gln 
785                 790                 795                 800 


Thr Ser Pro Gln Arg Gly Asn Leu Pro Thr Ser Gly Asn Ile Ser Gly 
                805                 810                 815     


Phe Ile Arg Arg Leu Phe Leu Gln Leu Met Leu Glu Asp Glu Lys Val 
            820                 825                 830         


Thr Met Phe Leu Gln Ser Pro Cys Pro Leu Tyr Lys Gly Arg Ile Asn 
        835                 840                 845             


Ala Thr Ser His Val Ile Gln His Pro Met Tyr Gly Ala Gly His Lys 
    850                 855                 860                 


Phe Arg Thr Leu His Leu Pro Val Ser Thr Thr Leu Ser Asp Val Leu 
865                 870                 875                 880 


Asp Arg Val Ser Asp Thr Pro Ser Ile Thr Ala Lys Leu Ile Ser Glu 
                885                 890                 895     


Gln Lys Asp Asp Lys Glu Lys Lys Asn His Glu Glu Lys Glu Lys Val 
            900                 905                 910         


Lys Ala Glu Asn Gly Phe Gln Asp Asn Tyr Ser Val Val Val Ala Ser 
        915                 920                 925             


Gly Leu Lys Ser Gln Ser Lys Arg Ala Val Ser Ala Thr Pro Pro Arg 
    930                 935                 940                 


Pro Pro Ser Arg Arg Gly Arg Thr Ile Pro Asp Lys Ile Gly Ser Thr 
945                 950                 955                 960 


Ser Gly Ala Glu Ala Ala Asn Lys Ile Ile Thr Val Pro Val Phe His 
                965                 970                 975     


Leu Phe His Lys Leu Leu Ala Gly Gln Pro Leu Pro Ala Glu Met Thr 
            980                 985                 990         


Leu Ala Gln Leu Leu Thr Leu Leu  Tyr Asp Arg Lys Leu  Pro Gln Gly 
        995                 1000                 1005             


Tyr Arg  Ser Ile Asp Leu Thr  Val Lys Leu Gly Ser  Arg Val Ile 
    1010                 1015                 1020             


Thr Asp  Pro Ser Leu Ser Lys  Thr Asp Ser Tyr Lys  Arg Leu His 
    1025                 1030                 1035             


Pro Glu  Lys Asp His Gly Asp  Leu Leu Ala Ser Cys  Pro Glu Asp 
    1040                 1045                 1050             


Glu Ala  Leu Thr Pro Gly Asp  Glu Cys Met Asp Gly  Ile Leu Asp 
    1055                 1060                 1065             


Glu Ser  Leu Leu Glu Thr Cys  Pro Ile Gln Ser Pro  Leu Gln Val 
    1070                 1075                 1080             


Phe Ala  Gly Met Gly Gly Leu  Ala Leu Ile Ala Glu  Arg Leu Ser 
    1085                 1090                 1095             


Met Leu  Tyr Pro Glu Val Ile  Gln Gln Val Ser Ala  Pro Val Val 
    1100                 1105                 1110             


Thr Ser  Thr Thr Leu Glu Lys  Pro Lys Asp Ser Asp  Gln Phe Glu 
    1115                 1120                 1125             


Trp Val  Thr Ile Glu Gln Ser  Gly Glu Leu Val Tyr  Glu Ala Pro 
    1130                 1135                 1140             


Glu Thr  Val Ala Ala Glu Pro  Pro Pro Ile Lys Ser  Ala Val Gln 
    1145                 1150                 1155             


Thr Met  Ser Pro Ile Pro Ala  His Ser Leu Ala Ala  Phe Gly Leu 
    1160                 1165                 1170             


Phe Leu  Arg Leu Pro Gly Tyr  Ala Glu Val Leu Leu  Lys Glu Arg 
    1175                 1180                 1185             


Lys His  Ala Gln Cys Leu Leu  Arg Leu Val Leu Gly  Val Thr Asp 
    1190                 1195                 1200             


Asp Gly  Glu Gly Ser His Ile  Leu Gln Ser Pro Ser  Ala Asn Val 
    1205                 1210                 1215             


Leu Pro  Thr Leu Pro Phe His  Val Leu Arg Ser Leu  Phe Ser Thr 
    1220                 1225                 1230             


Thr Pro  Leu Thr Thr Asp Asp  Gly Val Leu Leu Arg  Arg Met Ala 
    1235                 1240                 1245             


Leu Glu  Ile Gly Ala Leu His  Leu Ile Leu Val Cys  Leu Ser Ala 
    1250                 1255                 1260             


Leu Ser  His His Ser Pro Arg  Val Pro Asn Ser Ser  Val Asn Gln 
    1265                 1270                 1275             


Thr Glu  Pro Gln Val Ser Ser  Ser His Asn Pro Thr  Ser Thr Glu 
    1280                 1285                 1290             


Glu Gln  Gln Leu Tyr Trp Ala  Lys Gly Thr Gly Phe  Gly Thr Gly 
    1295                 1300                 1305             


Ser Thr  Ala Ser Gly Trp Asp  Val Glu Gln Ala Leu  Thr Lys Gln 
    1310                 1315                 1320             


Arg Leu  Glu Glu Glu His Val  Thr Cys Leu Leu Gln  Val Leu Ala 
    1325                 1330                 1335             


Ser Tyr  Ile Asn Pro Val Ser  Ser Ala Val Asn Gly  Glu Ala Gln 
    1340                 1345                 1350             


Ser Ser  His Glu Thr Arg Gly  Gln Asn Ser Asn Ala  Leu Pro Ser 
    1355                 1360                 1365             


Val Leu  Leu Glu Leu Leu Ser  Gln Ser Cys Leu Ile  Pro Ala Met 
    1370                 1375                 1380             


Ser Ser  Tyr Leu Arg Asn Asp  Ser Val Leu Asp Met  Ala Arg His 
    1385                 1390                 1395             


Val Pro  Leu Tyr Arg Ala Leu  Leu Glu Leu Leu Arg  Ala Ile Ala 
    1400                 1405                 1410             


Ser Cys  Ala Ala Met Val Pro  Leu Leu Leu Pro Leu  Ser Thr Glu 
    1415                 1420                 1425             


Asn Gly  Glu Glu Glu Glu Glu  Gln Ser Glu Cys Gln  Thr Ser Val 
    1430                 1435                 1440             


Gly Thr  Leu Leu Ala Lys Met  Lys Thr Cys Val Asp  Thr Tyr Thr 
    1445                 1450                 1455             


Asn Arg  Leu Arg Ser Lys Arg  Glu Asn Val Lys Thr  Gly Val Lys 
    1460                 1465                 1470             


Pro Asp  Ala Ser Asp Gln Glu  Pro Glu Gly Leu Thr  Leu Leu Val 
    1475                 1480                 1485             


Pro Asp  Ile Gln Lys Thr Ala  Glu Ile Val Tyr Ala  Ala Thr Thr 
    1490                 1495                 1500             


Ser Leu  Arg Gln Ala Asn Gln  Glu Lys Lys Leu Gly  Glu Tyr Ser 
    1505                 1510                 1515             


Lys Lys  Ala Ala Met Lys Pro  Lys Pro Leu Ser Val  Leu Lys Ser 
    1520                 1525                 1530             


Leu Glu  Glu Lys Tyr Val Ala  Val Met Lys Lys Leu  Gln Phe Asp 
    1535                 1540                 1545             


Thr Phe  Glu Met Val Ser Glu  Asp Glu Asp Gly Lys  Leu Gly Phe 
    1550                 1555                 1560             


Lys Val  Asn Tyr His Tyr Met  Ser Gln Val Lys Asn  Ala Asn Asp 
    1565                 1570                 1575             


Ala Asn  Ser Ala Ala Arg Ala  Arg Arg Leu Ala Gln  Glu Ala Val 
    1580                 1585                 1590             


Thr Leu  Ser Thr Ser Leu Pro  Leu Ser Ser Ser Ser  Ser Val Phe 
    1595                 1600                 1605             


Val Arg  Cys Asp Glu Glu Arg  Leu Asp Ile Met Lys  Val Leu Ile 
    1610                 1615                 1620             


Thr Gly  Pro Ala Asp Thr Pro  Tyr Ala Asn Gly Cys  Phe Glu Phe 
    1625                 1630                 1635             


Asp Val  Tyr Phe Pro Gln Asp  Tyr Pro Ser Ser Pro  Pro Leu Val 
    1640                 1645                 1650             


Asn Leu  Glu Thr Thr Gly Gly  His Ser Val Arg Phe  Asn Pro Asn 
    1655                 1660                 1665             


Leu Tyr  Asn Asp Gly Lys Val  Cys Leu Ser Ile Leu  Asn Thr Trp 
    1670                 1675                 1680             


His Gly  Arg Pro Glu Glu Lys  Trp Asn Pro Gln Thr  Ser Ser Phe 
    1685                 1690                 1695             


Leu Gln  Val Leu Val Ser Val  Gln Ser Leu Ile Leu  Val Ala Glu 
    1700                 1705                 1710             


Pro Tyr  Phe Asn Glu Pro Gly  Tyr Glu Arg Ser Arg  Gly Thr Pro 
    1715                 1720                 1725             


Ser Gly  Thr Gln Ser Ser Arg  Glu Tyr Asp Gly Asn  Ile Arg Gln 
    1730                 1735                 1740             


Ala Thr  Val Lys Trp Ala Met  Leu Glu Gln Ile Arg  Asn Pro Ser 
    1745                 1750                 1755             


Pro Cys  Phe Lys Glu Val Ile  His Lys His Phe Tyr  Leu Lys Arg 
    1760                 1765                 1770             


Val Glu  Ile Met Ala Gln Cys  Glu Glu Trp Ile Ala  Asp Ile Gln 
    1775                 1780                 1785             


Gln Tyr  Ser Ser Asp Lys Arg  Val Gly Arg Thr Met  Ser His His 
    1790                 1795                 1800             


Ala Ala  Ala Leu Lys Arg His  Thr Ala Gln Leu Arg  Glu Glu Leu 
    1805                 1810                 1815             


Leu Lys  Leu Pro Cys Pro Glu  Asp Leu Asp Pro Asp  Thr Asp Asp 
    1820                 1825                 1830             


Ala Pro  Glu Val Cys Arg Ala  Thr Thr Gly Ala Glu  Glu Thr Leu 
    1835                 1840                 1845             


Met His  Asp Gln Val Lys Pro  Ser Ser Ser Lys Glu  Leu Pro Ser 
    1850                 1855                 1860             


Asp Phe  Gln Leu 
    1865         


<210> 51
<211> 117
<212> PRT
<213> Homo sapiens

<400> 51
Arg Asp His Phe Ala Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr 
1               5                   10                  15      


Leu Leu Arg Thr Gly Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro 
            20                  25                  30          


Arg Asn Pro Ala Met Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln 
        35                  40                  45              


Asn Trp Pro Asp Tyr Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala 
    50                  55                  60                  


Gly Leu Tyr Tyr Thr Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys 
65                  70                  75                  80  


Gly Gly Lys Leu Lys Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu 
                85                  90                  95      


His Arg Arg His Phe Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu 
            100                 105                 110         


Asn Ile Arg Ser Glu 
        115         


<210> 52

<400> 52
000


<210> 53
<211> 96
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      XBIR3 sequence

<400> 53
Met Ser Thr Asn Leu Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala 
1               5                   10                  15      


Arg Ile Phe Thr Phe Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln 
            20                  25                  30          


Leu Ala Arg Ala Gly Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys 
        35                  40                  45              


Cys Phe His Cys Gly Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp 
    50                  55                  60                  


Pro Trp Glu Gln His Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu 
65                  70                  75                  80  


Glu Gln Lys Gly Gln Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser 
                85                  90                  95      


<210> 54
<211> 69
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      XBIR2 sequence

<400> 54
Met Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr Ala 
1               5                   10                  15      


His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr Gly 
            20                  25                  30          


Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys Asn 
        35                  40                  45              


Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe Pro 
    50                  55                  60                  


Asn Cys Phe Phe Val 
65                  


<210> 55
<211> 118
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      BIR2 sequence

<400> 55
Met Arg Asp His Phe Ala Leu Asp Arg Pro Ser Glu Thr His Ala Asp 
1               5                   10                  15      


Tyr Leu Leu Arg Thr Gly Gln Val Val Asp Ile Ser Asp Thr Ile Tyr 
            20                  25                  30          


Pro Arg Asn Pro Ala Met Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe 
        35                  40                  45              


Gln Asn Trp Pro Asp Tyr Ala His Leu Thr Pro Arg Glu Leu Ala Ser 
    50                  55                  60                  


Ala Gly Leu Tyr Tyr Thr Gly Ile Gly Asp Gln Val Gln Cys Phe Cys 
65                  70                  75                  80  


Cys Gly Gly Lys Leu Lys Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser 
                85                  90                  95      


Glu His Arg Arg His Phe Pro Asn Cys Phe Phe Val Leu Gly Arg Asn 
            100                 105                 110         


Leu Asn Ile Arg Ser Glu 
        115             


<210> 56
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(12) 
<223> This sequence may encompass 3-12 residues

<400> 56
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          


<210> 57
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(18) 
<223> This sequence may encompass 3-6 "Pro Pro Arg"
      repeating units

<400> 57
Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro 
1               5                   10                  15      


Pro Arg 
        


<210> 58
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(18) 
<223> This sequence may encompass 3-6 "Pro Arg Arg"
      repeating units

<400> 58
Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro 
1               5                   10                  15      


Arg Arg 
        


<210> 59
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Leu Glu His Asp 
1               


<210> 60
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Leu Glu His Asp 
1               


<210> 61
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RING finger domain sequence

<400> 61
Cys Cys Cys His Cys Cys Cys Cys 
1               5               


