                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       Tang, Yajun
       Shuldiner, Alan
       Van Hout, Cristopher 
 
<120>  A Rodent Model Of Increased Bone Mineral Density

<130>  189238.03002 (3277) (10651WO-01)

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  7199
<212>  DNA
<213>  mus musculus

<400>  1
agagacaagt gactgtgtgt gtcagcgtcc atctttcttc ttgctctgca ctggtcctgg       60

tcagaaatgt tgaacttgac tggcctccac ctgcttccct ttcctgggac cacagagcct      120

tgaccctgca tggggctatc tggctatatt ttctccaagt gctttcacca tgcttcctct      180

tgatcattgg tgactatggc tctcaaaatt ggtgcaaaat gaagattagc ttttctctag      240

tcatcacaat agctgtacca acctctcttt ccaatagctt cacagtgagc attttgacca      300

tagtatgatg cacccactag gcctatgtaa taacaatgac gaagaggact tgtatgaata      360

tggctgggta ggagtggtga agcttgaaca gccagaattg gaccccaaac catgtctcac      420

tgtcctgggc aaggccaaga gagcagttca gcggggagct actgcagtta tctttgatgt      480

atctgaaaat ccagaagcca tcgaccagct aaaccaaggc tcagaagacc ctcttaagag      540

gccagtggtg tatgtgaagg gtgcagatgc tatcaagctg atgaacattg tcaacaagca      600

gaaagtagct cgagcaagga tccagcacct ccctcctcga caacccaccg agtactttga      660

catgggaatt ttcctggcct tcttcgtcgt ggtctccttg gtctgcctca ttctccttgt      720

caaaatcaag ctgaagcaac gtcgtagtca gaattccatg aacaggctgg ctgtgcaggc      780

tctggagaag atggaaacca gaaagttcaa ctccaagagc aaggggcgcc gggaaggaag      840

ctgtggggcc ctggacacac tgagcagcgg ctccacatcc gactgtgcca tctgtctgga      900

gaagtacatt gacggagagg agcttcgggt catcccttgt actcatcggt tccacaggaa      960

gtgtgtggat ccatggctac tgcagcacca cacctgcccc cactgtcggc acaacatcat     1020

agaacaaaag ggaaatccag gtgctgtttg tgtggagaca agcaacctta cacgtggtcg     1080

gcagccaaga gtgaccctac cggtacatta cccaggccgt gtgcatagga ccaatgccat     1140

cccagcctac cctactagga caagtatgga ctcccatggc aaccctgtca cactgctaac     1200

catggaccgg catggggagc agaacctcta ttctccacaa acacccacct atgtccgtgg     1260

ctacccaccc ctgcacctgg accacactct ggcccctcat cgctgcagcc tggaacaccg     1320

ggcctactca ccagcccatc ccttccgcag gcccaagttc agcagccgca gcttctccaa     1380

ggcagcttgc ttctcccagt atgagaccat gtaccaacac tactacttcc agggtctcag     1440

ctacccagag caggagggcc agacaatacc cagcgtcaca cccaggggcc aatcccgtgc     1500

cttcccacca agtggtgcca gcagcctgct cttccccaca atggtacatg tggcccctcc     1560

aacccacgtg gagagtggca gcacatctag cttcagttgc tatcatgggc accgttctgt     1620

gtgtagcggc tacctggctg actgtcctgg cagcgatagc agcagcaaca gctctggcca     1680

gtgccgctgc tcttccagtg actccgtggt ggactgcaca gaagtcagca accaaggtgt     1740

gtatgggagc tgttccacct tccgaagctc cctcagcagc gactatgacc ccttcatcta     1800

ccgcagccgg gggcctgctg tgcaccttga gggctcccct ccaccagagg agctcccagc     1860

aggacacagt caaagtgctg ggaggggcga gccatggcta ggccctgcct ctccctcagg     1920

ggaccagctg tccacctgca gcctggagat gaactacagc agcaactcct cgctggaacc     1980

cagagggccc aacagctcta cctcagaagt ggggctcgag gtttctcctg gggctgccct     2040

ggacctcagg aggacctgga aagggggtcc agagggacca tcatgtgctt gctgcttcga     2100

gccccagccc ttcccgccgg gctctgggat agaaacaagt gcaggtggca gcagtttatt     2160

cctgggtcct cggctcctcg aggactgcaa ccctccaagt ggggagccac agctggggag     2220

ctcccagggc ctgtatggtc ttcactcaga ccattatcct aggacagatg gggtgaaata     2280

tgagggcttg ccctgctgct tctatgaaga gaagcaggtg gcccacagtg ctggcagggg     2340

caatggctgc tacactgagg actattcagt gagtgtacag tacacactca ccgaggaacc     2400

cccacccagc tgttatgcag ggccccggga cctgagccag cgcatcccca ttattccaga     2460

ggatgtagac tgtgacttgg gcttgcccca agactgccac gggatgcaca accacagccc     2520

ctggggtggg gcactgagct tggacgttcc ccgactccac tggagtctag gcacaacccg     2580

ggaagaggaa caggctccat gttaccaagc tgaggtgcag cctggctgct ctccagagga     2640

ggcaggtgct tccagggcta gcctctccag tgccccccag gacactcagg agtctcatgc     2700

cctggctgct gaggcttcag gtgagaacag atgacagtag tatttgtata aggatccttg     2760

tctcagacct tttttgtttg gcttcctctg tgcctttggc ttctgtactt gatgactttc     2820

aaacattgct tttcagccct acccctcctc aaacgctata tccatgatgt tggcatctcc     2880

tcccatcaga tgcttcatat cccaaaagca catctcaatt ttattaacta ttctgcatct     2940

cctatggttc cccttagtcc atccctgtgt ctatcaaaga gcaaagtcct gacagaggtc     3000

actgcaattg tttgctctcc cacttgggag accttaatca cggtccttat actagaaatg     3060

ctatcgtgac ttttcagtta cctttataag atgtctgttt ttgtgtgttt tctgtttggt     3120

ttttgagaca gggtttcttt gtgtagacca ggctagtctt gaactcagat ctctctgctt     3180

ctgtctcctg agtactactg ggattaaagg catgcactaa cactgcccag cataagatat     3240

cttctaactg gagatgctcc ttttgatcca gcctgtgtct tgttcctgca gcatgtcagg     3300

ttcatttcca tctccatcga gatccttcga tctcagctcc acagccttcc tttccccatc     3360

agtgtcactc ccactgctat ctcctaatca cctcaagcca ggcacctcgt gggaagatct     3420

gtgatctgtg aggagtctcc cctggccccc tgggaactaa ttcacttaac ttcagttcta     3480

cctatgcttc tgtgatatct taggagattc agtataggca tcaagggaga cctgctcacc     3540

ctctgcccca acagctgttc tcagtgtaga cttgagctcc tcaggaaagg agccattgct     3600

gcccccttta tcacacagag ccaaatcacc attgtgaact atcacatcca agggccctat     3660

ggatgggcta gggatgctca aggaccttac ctgatacgta ctacccaaag cctgctgtgc     3720

tggctctctc cagacccttg atgactgttc tccctctttc tcccaggacc aggatctggc     3780

ccaggcatcg gtacgggagc ttgagctcaa aaggaactct tatgtagaaa tcgtgaactg     3840

tacggagact tcaaagtctg gcttccttca aaactactat acacacacac acacacacac     3900

acacacacac acacacacac acacacacac atatatatat tttagctttg acaaacacaa     3960

aagtggtaat aaagagagcc ctcctcaacc caaaatgtga gccacctgtg gcatcccttc     4020

ctctttaaca aaccaacaga caaaaatctc ttgagtcctt tgcctcttta ataatgtgtt     4080

gttctgtttt gtaatgtgtg cttgggtttc tgaggtgtgt gggattgagt tctctgcttt     4140

ttttctaaaa tattatatgt aaatgtaaaa agttatttaa atatatattt taaagaaccc     4200

taactaccaa cttctgttga aaaaaaaaat cactgctgca ttaaatgaac cacatcatgt     4260

gtcaatactg ttgtctccct ggagggacct caggcctttg aaaagctcag ggttacacct     4320

gccttattga aaatgaacca gaaacttgaa gtaaaaagct ccaaggaaca atacaaagct     4380

gcctcatcct ttttcccttt tttgaggcaa atctgaactt ctgggcttct gggaagccac     4440

acctctcctg cccacacctg taggcagcaa tggaacagga gggaagtggg ggcagtgtca     4500

agctattact gcctaggcca actttattgg agacagttct gcccattctc ttctgttcct     4560

ttggtaggtc tttatcccag cagaggctgt ggctgtgacc agccctgtta ctagggtctc     4620

tcctgcactc tgaccaccag tcaagggaag agacgctctc accctgtggc cttggagtct     4680

tttgtaaaat cattttgggc ttcatgccat caattgcagg ggtaatttaa atggggtgtg     4740

cagggtggac acccaggagg aatgttgatt tatggccttg gtgtcctgtg ggactagagg     4800

aacaagctct cctctcagta gcagtgcacc gctccttgaa aggcatgctg aggcacactt     4860

gtgcccatgg gtctagggca gccacacccc tcagctgttg cccccttagg ttgccttctt     4920

gggggacata tgcttgaacc acaagagtgt actaagctcc aattggacca gtcccccatc     4980

cccagaaaca ggcctctgcc tggtggctgc agcggttcac cttgccagca gatgtctgct     5040

agcctgtctg cctgatgcac tattatgtac tgattctcca cgagacagac tatcagatag     5100

ttcagaccca aagggtaggc ttttgtatat tttttccagc ctcttttttt ttaaggggaa     5160

gagtttttta aacccaaacc acttttggtt gtttttgtta ttgtttttaa gatgttttgt     5220

ttatttttaa aagggagaga gaattattta aaatcacttc agggattgta atccttttta     5280

ttcaaaatag tccttgttct taaaagtatt ttcttttcct tagaggaaac taatcggctt     5340

ggccctgtgt ttgctaactc ttctggtcac ttttagtcat tcatttagca gatgtctttt     5400

tccatcagga agagtttggc cgagtgggtc tgaaaactcg gttacagaat ggggaccacc     5460

tgggttgcca gagacagaaa tgacccttct tcccagtcag gctcccagga agtcatccca     5520

gggtccagat tgcacatttg agatgatcag aatactttgt tctttaaaac ctcgtcctag     5580

gatgagggca tttgcttatt tctatccaga atctaacaaa agaagtccca cgtcagatgg     5640

cccagttatt tgccctttag gaagtggcca tagtgaaatt tgttcttctg ccggactctg     5700

gaggtcggtc ccttgaggct atgcccagtg cacctgttgc tgagggtgtg agaagggcct     5760

aaactgttga catgtaatcg gggctgcctt tctttctggg gccaggagta gcagctgcta     5820

agaacagcag ctttccttac tgtgcaaggg ggggggtgga ggcacagctt ttaacatgaa     5880

ctgcaaagca cagcttctca ttgttgagat gtttgttgtt tctggttttc cttttttttt     5940

tttttttttt tttttttttt tgtgtgtgtg tgtctgtatg tgcatatttc tccattggct     6000

gaaacaaacc ccagaaagat tttgcctttg tcctgcctgg ctagaaaacc atttctcagt     6060

actcatagat gagtagagaa tttgaatgcc actaggcaga gttaaaaaaa caagttcaac     6120

tctcctttga aaaaatgcta ctagtgggtg acaggcactt gtaattgttg tagttttgga     6180

ctagtagaaa caaaagattt agagacaatt atcatctttg tgttgccaca tcagaccaga     6240

ataaaaccta tcttatgcac catttaaatc agaagaaata gtgtctatga agttctgaga     6300

gccacagtgc tctcttctgt gccctcttct ggggagggga agtggaaagg gagtgtcagt     6360

agtgtgtggt gattgtatag ccatggacaa ggagcacccc actgtccact gggagcctgt     6420

gtgtggaata gcaagtgtgg gcttgatacc agccctgggt gtaagacagc catgccaacc     6480

caaaatctag aaccagatga aaatggaagt taagtcattg tgtaccttga ggtgcctctg     6540

tggtcgtagc tccagaagct gaccatccat cccctctccc ccaggcccag accgctgtat     6600

ccgtgtccct ctttagtccc gtggttcagg cctttcccta tgtgcttctg ctctcaaagt     6660

ccacacagga ctgatgcttt taaaatgtgg tctgtaaaag aatttgaaag tatcatcttt     6720

taaactgacc tgcatttttc tattccttac ataaactttt tgtatcgtgt tggtctaatg     6780

acactatttt aatttttttt ttatttctcc catagcactt aatattttgt aaagattttt     6840

ttgtgataaa atggtctaag ggctcttttt ccacattacc attttaaaaa cttttaaaag     6900

ctagaaaaca acttatgtat attctgtata tgtatagcag cacatttcat ttatggaaat     6960

atgttctcag aatatttatt tactaatata tttatcttaa gccatgtctt atgttgagag     7020

tgtgacattg ttgaaataat cattgaaaat gactaacaag gccctgtaaa tacatgataa     7080

ttgcacacag attttacata tttgcagacc aaaaatgatt taaagcaagt tgtagtcgtc     7140

tatgattttg taacaaattg tacaaatgac tgtaaaaaaa aatacaattt tatcaagta      7199


<210>  2
<211>  2465
<212>  DNA
<213>  rattus norvegicus

<400>  2
gtcatttctc cacccctata aaatatctat ttttaggggt tttattgtgt tctcttcagt       60

gctcacctct ctgtaatgaa ttgaaataac cattggattg aaaaactatt ctgtgccata      120

aagtctgaag ttttgaagtg gcttttgctt catatgtaat aagaaatgca tgaagtgggt      180

tagatcagtc tgtggctagc ctgttgatat tttcttgcca ttttgtcttt tagatgcacc      240

cactaggcct atgtaataac aatgacgaag aggacttgta cgaatatggc tgggtaggag      300

tggtgaagct cgaacagcca gaattggacc ccaaaccatg tctcactgtc ctgggcaagg      360

ccaagagagc agttcagcgg ggagctactg ccgttatctt tgacgtatct gaaaacccag      420

aagccatcga ccagctaaac caaggctctg aagaccccct taagaggcca gtggtgtatg      480

tgaagggtgc agatgctgtc aagctgatga acattgtcaa caagcagaaa gtagctcgag      540

caaggatcca gcacctccct cctcgacaac ccaccgagta ctttgacatg gggattttcc      600

tggcattctt cgtcgtggtc tccttggtct gcctcattct ccttgtcaaa atcaagctga      660

agcagcgtcg tagtcagaat tccatgaaca ggctggccgt gcaggctctg gagaagatgg      720

aaaccagaaa gttcaactcc aagagcaagg ggcgccggga aggaagctgt ggggccctgg      780

atacacttag cagcggctcc acatccgact gtgccatctg tctggagaag tacattgatg      840

gagaggagct tcgggtcatc ccgtgtaccc atcgattcca cagaaagtgt ggggatccat      900

ggctactgca gcatcatacc cgtccccatt gtcggcacaa catcataggt aactgctaca      960

ggcctcgtca caccctgacc tacaaagatg acaagtgcgt gctgcacgct aggtggagaa     1020

tcagaagata ttggtttacg cgtgcgcgcc cacctgccca cctgcgacca actcatgccc     1080

acactctggc ccctcatcgc tgcagcctgg aacaccgggc ctactcacca gcccatccct     1140

tccgcaggcc caagttcagc agccgcagct tctccaaggc agcttgcttc tcccagtatg     1200

agaccatgta ccaacactac tacttccagg gtctcagcta cccagagcag gagagccagc     1260

cggtacctag cgtcacaccc aggggccagt cccgtgcctt cccaccaagt ggtggcagca     1320

gcctgctctt ccccaccatg gtgcatatgg cccctccagc ccatgtggag agtggcagca     1380

cgtctagctt cagttgctac cacgggcacc gttctgtgtg tagtggctac ctggctgact     1440

gtcctggcag cgatagcagc agcaacagct ctggccagtg ccgctgctct tccagtgact     1500

ctgtggtgga ctgcacagaa gtcagcaacc aaggtgtgta tgggagctgc tccaccttcc     1560

gaagctccct cagcagcgac tatgacccct tcatctaccg cagccggggg cctgctgtgc     1620

accttgaggg ctccccgcca ccagaggagc ttccagcagc ccacaatcaa ggtgctgggc     1680

ggggtgagcc atggctaggc cctgcctctc cctcagggga ccagctgtcc acctgcagcc     1740

tggagatgaa ctacagcagc aactcctcgc tggaacccag agggcccaac agctctacct     1800

cagaagtggg gctcgaggtt tctcctgggg ccgccctgga cctcaggagg acctggaaag     1860

ggggcccaga gggaccatca tgtgcttgct gctttgagcc ccagcccgtc acgctgggct     1920

ctgggatagg aacaactgca ggtggtagca gcttattcct gggtccccga ctccttgagg     1980

actgcaaccc tgcaagtggg gagccacaac tagggagctc ccagggcctg tatggccttc     2040

actcagacca ttatcctagg acagatgggg tgaaatatga gggcctgccc tgctgcttct     2100

atgaagagaa gcaggtggcc cacagtgctg gcaggggcaa tggctgctac actgaggact     2160

attcagtgag tgtgcagtac acactcaccg aggaaccccc acccagctgt tatgcagggg     2220

cccgggactt gagccagcgc atccccatta ttccagagga tgtagactgt gacttgggct     2280

tgccccaaga ctgccaaggg aggcacagcc acagcccctg gggtggagca ctgggcttgg     2340

atactaaaaa atgctttgtg gacaacggaa aaagacggaa caggctccac ctgttaccag     2400

ctgacggtgc agctgctgtt ccctacttct gcctccggag tactgggatt aaaggcgtgc     2460

actaa                                                                 2465


<210>  3
<211>  809
<212>  PRT
<213>  mus musculus

<400>  3

Met Met His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu Glu Asp Leu 
1               5                   10                  15      

Tyr Glu Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln Pro Glu Leu 
            20                  25                  30          

Asp Pro Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys Arg Ala Val 
        35                  40                  45              

Gln Arg Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu Asn Pro Glu 
    50                  55                  60                  

Ala Ile Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu Lys Arg Pro 
65                  70                  75                  80  

Val Val Tyr Val Lys Gly Ala Asp Ala Ile Lys Leu Met Asn Ile Val 
                85                  90                  95      

Asn Lys Gln Lys Val Ala Arg Ala Arg Ile Gln His Leu Pro Pro Arg 
            100                 105                 110         

Gln Pro Thr Glu Tyr Phe Asp Met Gly Ile Phe Leu Ala Phe Phe Val 
        115                 120                 125             

Val Val Ser Leu Val Cys Leu Ile Leu Leu Val Lys Ile Lys Leu Lys 
    130                 135                 140                 

Gln Arg Arg Ser Gln Asn Ser Met Asn Arg Leu Ala Val Gln Ala Leu 
145                 150                 155                 160 

Glu Lys Met Glu Thr Arg Lys Phe Asn Ser Lys Ser Lys Gly Arg Arg 
                165                 170                 175     

Glu Gly Ser Cys Gly Ala Leu Asp Thr Leu Ser Ser Gly Ser Thr Ser 
            180                 185                 190         

Asp Cys Ala Ile Cys Leu Glu Lys Tyr Ile Asp Gly Glu Glu Leu Arg 
        195                 200                 205             

Val Ile Pro Cys Thr His Arg Phe His Arg Lys Cys Val Asp Pro Trp 
    210                 215                 220                 

Leu Leu Gln His His Thr Cys Pro His Cys Arg His Asn Ile Ile Glu 
225                 230                 235                 240 

Gln Lys Gly Asn Pro Gly Ala Val Cys Val Glu Thr Ser Asn Leu Thr 
                245                 250                 255     

Arg Gly Arg Gln Pro Arg Val Thr Leu Pro Val His Tyr Pro Gly Arg 
            260                 265                 270         

Val His Arg Thr Asn Ala Ile Pro Ala Tyr Pro Thr Arg Thr Ser Met 
        275                 280                 285             

Asp Ser His Gly Asn Pro Val Thr Leu Leu Thr Met Asp Arg His Gly 
    290                 295                 300                 

Glu Gln Asn Leu Tyr Ser Pro Gln Thr Pro Thr Tyr Val Arg Gly Tyr 
305                 310                 315                 320 

Pro Pro Leu His Leu Asp His Thr Leu Ala Pro His Arg Cys Ser Leu 
                325                 330                 335     

Glu His Arg Ala Tyr Ser Pro Ala His Pro Phe Arg Arg Pro Lys Phe 
            340                 345                 350         

Ser Ser Arg Ser Phe Ser Lys Ala Ala Cys Phe Ser Gln Tyr Glu Thr 
        355                 360                 365             

Met Tyr Gln His Tyr Tyr Phe Gln Gly Leu Ser Tyr Pro Glu Gln Glu 
    370                 375                 380                 

Gly Gln Thr Ile Pro Ser Val Thr Pro Arg Gly Gln Ser Arg Ala Phe 
385                 390                 395                 400 

Pro Pro Ser Gly Ala Ser Ser Leu Leu Phe Pro Thr Met Val His Val 
                405                 410                 415     

Ala Pro Pro Thr His Val Glu Ser Gly Ser Thr Ser Ser Phe Ser Cys 
            420                 425                 430         

Tyr His Gly His Arg Ser Val Cys Ser Gly Tyr Leu Ala Asp Cys Pro 
        435                 440                 445             

Gly Ser Asp Ser Ser Ser Asn Ser Ser Gly Gln Cys Arg Cys Ser Ser 
    450                 455                 460                 

Ser Asp Ser Val Val Asp Cys Thr Glu Val Ser Asn Gln Gly Val Tyr 
465                 470                 475                 480 

Gly Ser Cys Ser Thr Phe Arg Ser Ser Leu Ser Ser Asp Tyr Asp Pro 
                485                 490                 495     

Phe Ile Tyr Arg Ser Arg Gly Pro Ala Val His Leu Glu Gly Ser Pro 
            500                 505                 510         

Pro Pro Glu Glu Leu Pro Ala Gly His Ser Gln Ser Ala Gly Arg Gly 
        515                 520                 525             

Glu Pro Trp Leu Gly Pro Ala Ser Pro Ser Gly Asp Gln Leu Ser Thr 
    530                 535                 540                 

Cys Ser Leu Glu Met Asn Tyr Ser Ser Asn Ser Ser Leu Glu Pro Arg 
545                 550                 555                 560 

Gly Pro Asn Ser Ser Thr Ser Glu Val Gly Leu Glu Val Ser Pro Gly 
                565                 570                 575     

Ala Ala Leu Asp Leu Arg Arg Thr Trp Lys Gly Gly Pro Glu Gly Pro 
            580                 585                 590         

Ser Cys Ala Cys Cys Phe Glu Pro Gln Pro Phe Pro Pro Gly Ser Gly 
        595                 600                 605             

Ile Glu Thr Ser Ala Gly Gly Ser Ser Leu Phe Leu Gly Pro Arg Leu 
    610                 615                 620                 

Leu Glu Asp Cys Asn Pro Pro Ser Gly Glu Pro Gln Leu Gly Ser Ser 
625                 630                 635                 640 

Gln Gly Leu Tyr Gly Leu His Ser Asp His Tyr Pro Arg Thr Asp Gly 
                645                 650                 655     

Val Lys Tyr Glu Gly Leu Pro Cys Cys Phe Tyr Glu Glu Lys Gln Val 
            660                 665                 670         

Ala His Ser Ala Gly Arg Gly Asn Gly Cys Tyr Thr Glu Asp Tyr Ser 
        675                 680                 685             

Val Ser Val Gln Tyr Thr Leu Thr Glu Glu Pro Pro Pro Ser Cys Tyr 
    690                 695                 700                 

Ala Gly Pro Arg Asp Leu Ser Gln Arg Ile Pro Ile Ile Pro Glu Asp 
705                 710                 715                 720 

Val Asp Cys Asp Leu Gly Leu Pro Gln Asp Cys His Gly Met His Asn 
                725                 730                 735     

His Ser Pro Trp Gly Gly Ala Leu Ser Leu Asp Val Pro Arg Leu His 
            740                 745                 750         

Trp Ser Leu Gly Thr Thr Arg Glu Glu Glu Gln Ala Pro Cys Tyr Gln 
        755                 760                 765             

Ala Glu Val Gln Pro Gly Cys Ser Pro Glu Glu Ala Gly Ala Ser Arg 
    770                 775                 780                 

Ala Ser Leu Ser Ser Ala Pro Gln Asp Thr Gln Glu Ser His Ala Leu 
785                 790                 795                 800 

Ala Ala Glu Ala Ser Gly Glu Asn Arg 
                805                 


<210>  4
<211>  743
<212>  PRT
<213>  rattus norvegicus

<400>  4

Met His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu Glu Asp Leu Tyr 
1               5                   10                  15      

Glu Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln Pro Glu Leu Asp 
            20                  25                  30          

Pro Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys Arg Ala Val Gln 
        35                  40                  45              

Arg Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu Asn Pro Glu Ala 
    50                  55                  60                  

Ile Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu Lys Arg Pro Val 
65                  70                  75                  80  

Val Tyr Val Lys Gly Ala Asp Ala Val Lys Leu Met Asn Ile Val Asn 
                85                  90                  95      

Lys Gln Lys Val Ala Arg Ala Arg Ile Gln His Leu Pro Pro Arg Gln 
            100                 105                 110         

Pro Thr Glu Tyr Phe Asp Met Gly Ile Phe Leu Ala Phe Phe Val Val 
        115                 120                 125             

Val Ser Leu Val Cys Leu Ile Leu Leu Val Lys Ile Lys Leu Lys Gln 
    130                 135                 140                 

Arg Arg Ser Gln Asn Ser Met Asn Arg Leu Ala Val Gln Ala Leu Glu 
145                 150                 155                 160 

Lys Met Glu Thr Arg Lys Phe Asn Ser Lys Ser Lys Gly Arg Arg Glu 
                165                 170                 175     

Gly Ser Cys Gly Ala Leu Asp Thr Leu Ser Ser Gly Ser Thr Ser Asp 
            180                 185                 190         

Cys Ala Ile Cys Leu Glu Lys Tyr Ile Asp Gly Glu Glu Leu Arg Val 
        195                 200                 205             

Ile Pro Cys Thr His Arg Phe His Arg Lys Cys Gly Asp Pro Trp Leu 
    210                 215                 220                 

Leu Gln His His Thr Arg Pro His Cys Arg His Asn Ile Ile Gly Asn 
225                 230                 235                 240 

Cys Tyr Arg Pro Arg His Thr Leu Thr Tyr Lys Asp Asp Lys Cys Val 
                245                 250                 255     

Leu His Ala Arg Trp Arg Ile Arg Arg Tyr Trp Phe Thr Arg Ala Arg 
            260                 265                 270         

Pro Pro Ala His Leu Arg Pro Thr His Ala His Thr Leu Ala Pro His 
        275                 280                 285             

Arg Cys Ser Leu Glu His Arg Ala Tyr Ser Pro Ala His Pro Phe Arg 
    290                 295                 300                 

Arg Pro Lys Phe Ser Ser Arg Ser Phe Ser Lys Ala Ala Cys Phe Ser 
305                 310                 315                 320 

Gln Tyr Glu Thr Met Tyr Gln His Tyr Tyr Phe Gln Gly Leu Ser Tyr 
                325                 330                 335     

Pro Glu Gln Glu Ser Gln Pro Val Pro Ser Val Thr Pro Arg Gly Gln 
            340                 345                 350         

Ser Arg Ala Phe Pro Pro Ser Gly Gly Ser Ser Leu Leu Phe Pro Thr 
        355                 360                 365             

Met Val His Met Ala Pro Pro Ala His Val Glu Ser Gly Ser Thr Ser 
    370                 375                 380                 

Ser Phe Ser Cys Tyr His Gly His Arg Ser Val Cys Ser Gly Tyr Leu 
385                 390                 395                 400 

Ala Asp Cys Pro Gly Ser Asp Ser Ser Ser Asn Ser Ser Gly Gln Cys 
                405                 410                 415     

Arg Cys Ser Ser Ser Asp Ser Val Val Asp Cys Thr Glu Val Ser Asn 
            420                 425                 430         

Gln Gly Val Tyr Gly Ser Cys Ser Thr Phe Arg Ser Ser Leu Ser Ser 
        435                 440                 445             

Asp Tyr Asp Pro Phe Ile Tyr Arg Ser Arg Gly Pro Ala Val His Leu 
    450                 455                 460                 

Glu Gly Ser Pro Pro Pro Glu Glu Leu Pro Ala Ala His Asn Gln Gly 
465                 470                 475                 480 

Ala Gly Arg Gly Glu Pro Trp Leu Gly Pro Ala Ser Pro Ser Gly Asp 
                485                 490                 495     

Gln Leu Ser Thr Cys Ser Leu Glu Met Asn Tyr Ser Ser Asn Ser Ser 
            500                 505                 510         

Leu Glu Pro Arg Gly Pro Asn Ser Ser Thr Ser Glu Val Gly Leu Glu 
        515                 520                 525             

Val Ser Pro Gly Ala Ala Leu Asp Leu Arg Arg Thr Trp Lys Gly Gly 
    530                 535                 540                 

Pro Glu Gly Pro Ser Cys Ala Cys Cys Phe Glu Pro Gln Pro Val Thr 
545                 550                 555                 560 

Leu Gly Ser Gly Ile Gly Thr Thr Ala Gly Gly Ser Ser Leu Phe Leu 
                565                 570                 575     

Gly Pro Arg Leu Leu Glu Asp Cys Asn Pro Ala Ser Gly Glu Pro Gln 
            580                 585                 590         

Leu Gly Ser Ser Gln Gly Leu Tyr Gly Leu His Ser Asp His Tyr Pro 
        595                 600                 605             

Arg Thr Asp Gly Val Lys Tyr Glu Gly Leu Pro Cys Cys Phe Tyr Glu 
    610                 615                 620                 

Glu Lys Gln Val Ala His Ser Ala Gly Arg Gly Asn Gly Cys Tyr Thr 
625                 630                 635                 640 

Glu Asp Tyr Ser Val Ser Val Gln Tyr Thr Leu Thr Glu Glu Pro Pro 
                645                 650                 655     

Pro Ser Cys Tyr Ala Gly Ala Arg Asp Leu Ser Gln Arg Ile Pro Ile 
            660                 665                 670         

Ile Pro Glu Asp Val Asp Cys Asp Leu Gly Leu Pro Gln Asp Cys Gln 
        675                 680                 685             

Gly Arg His Ser His Ser Pro Trp Gly Gly Ala Leu Gly Leu Asp Thr 
    690                 695                 700                 

Lys Lys Cys Phe Val Asp Asn Gly Lys Arg Arg Asn Arg Leu His Leu 
705                 710                 715                 720 

Leu Pro Ala Asp Gly Ala Ala Ala Val Pro Tyr Phe Cys Leu Arg Ser 
                725                 730                 735     

Thr Gly Ile Lys Gly Val His 
            740             


<210>  5
<211>  4134
<212>  DNA
<213>  mus musculus

<400>  5
accgagtact ttgacatggg aattttcctg gccttcttcg tcgtggtctc cttggtctgc       60

ctcattctcc ttgtcaaaat caagctgaag caacgtcgta gtcaggtaac cctaggagtg      120

acctgtgaac cccattaccc tgttcctgat gacagctggg gaaccaggtg tagtggcaca      180

ctcttttaat cccagtactt gggaggcaga ggcaggtggg tctccgagtt caaggccagc      240

ttagtctaca tagtgagttc cagtagagtc agggctgcta cgcagagaaa ccctgtctct      300

caaaacttaa aaacaaaaaa aagaaaagaa agttagggat ctgaccagcc tgttgtctat      360

ggcacccaaa ctacctcagt ggcttggagg gtaccagacc tcaagtactg agcccccatg      420

tggagaagag caggcttgtc cacaaaggcc tcagcattga gggtgttcca aactagtatt      480

ttgagggaac tgtttaaata aatgctgctt tggagcatga gaccttgctc ctttagtaga      540

tctgaggttg gtagaaataa agacggtcag gctcctaggt cttatgatga aatttgcctc      600

tgccaggtcc atctgttaaa tgttgatgaa caggtagcta tagctagtac tctagcaatc      660

ccatcactgt ggcttacaag agagaagtac ctataggcag aggatggtga gagggaaagc      720

aggagactag actttgagat atgtggcggt gtgacatctt gggagaaagg gcaccttaga      780

tagtgactgt caaaaggagg ttacagttgt caggagggtt gaggggccac caccagcaag      840

acaggactag gggttagtat ttgtgcactc acaccgcatg tcgggtgctg agcactcacg      900

tctcatttcc ctggcttcct tcaacaagga gggacatttg acctagagcc ttctaaaacc      960

caatgttgca cagaattaag tatcagagac agggaattgc ctttcctctt gaaggcaaga     1020

ctttgtagta gagtcagtgt cgtgggcact gttggtctag gaaatacagt gcaatatgaa     1080

tttggaacag ctcctcaggg atctgtttga cctaagtgag attagttttg tctgtcacag     1140

tgtcatgagt gccatggcct ggggtatgcc taccactgat aatgtgtccc aacactgacc     1200

atgctctgcc atgcagaatt ccatgaacag gctggctgtg caggctctgg agaagatgga     1260

aaccagaaag ttcaactcca agagcaaggg gcgccgggaa ggaagctgtg gggccctgga     1320

cacactgagc agcggctcca catccgactg tgccatctgt ctggagaagt acattgacgg     1380

agaggtagct gcaggatcag ggcctgcctt gggtgggaag ggatgtacag aggccccagg     1440

aggtgctggg gactaccatg accatgacta gagttctcca caacctagat tcagtgcgta     1500

agcttctaaa ggcatttctt cctggggctg ggaaaacaca atactctata gatggtctag     1560

ctaataagta catggttggc cagggtagta gcacatgcca gtagttttag tgcttgagag     1620

actactcaaa agaagtgtga gtttaagatc ccggctttgc caaaatgcac atggttgaac     1680

agaaaatata tagatgtaag atcaagttgc ttactttgct ttgaagaact ggttaagtaa     1740

tgagtttact tggagaaagt ctagaaatgt gatgcctttt gttttttcct gtagctcttt     1800

attaagagtt gcaagtatca ggaacagcac agaaccacca ttcacatatt ttgctacctt     1860

tatgtctgtc ttcagatgga caggtacata catagtggag aggaaactgc ctgagagtcc     1920

aggccttgaa cagcccctgg ataagatcga cctcccccct gatgtgtagg ttgctgggtg     1980

gaagtatgtt tgtacacagg cccttggatg atacgcttgt gtagactgta cgtacagact     2040

cctgggctct aacctagccc aggcagattc ttggtttgtg aacttgacga gtgacttcat     2100

tctgtgtctg cgcttgtgac accaaccagc atactagatt ctcacaaaca ctatttaggt     2160

gagaagatac aagcagtctt tttatttttc ttttaagatt tatgtatgta tatgagcact     2220

ctaatttgcg tgtacacctg cgtgccagga tcccattaca gatagttgtg agtcaccatg     2280

tggttgctgg aaattgaact cgggacctct gaaagagcag ccactaagcc atctctccaa     2340

ccctgataca ggcattctaa agcaccatat tggctattta ttttaatatc actgtatcag     2400

actggtggga aaaggggaaa aaaaagaaaa gaaaaggaat aagaacaagt cagtaggata     2460

cttcggtttt ctttcaaatt ggctgctttc cttagaaaca atgtggccct atcaagtgtt     2520

ccttttctac ttgacctcat tcaatggtac ttagaggcaa ccatccagta gttctcaacc     2580

ttcctaatgc tgtgaccctt taatacagtt tctcatattg tggtgacccc caaccgtaag     2640

ataattttca tgactactaa ataactgtaa ttttgttatt gttatgaaac gtaatataca     2700

aagctgtatt ttccgataat tttttgaggt cttgacccat aggttgggaa ccacagatct     2760

atacctatat agatagcctc gggtatttgt tactctccct gcaaaccctt tgttccctgg     2820

cctgtggctt tggacttaga tgtgccccca gttcctggaa aggaatctgc ttccttatgc     2880

tccttgtctt ttagccctga tagctgtggt taggacagat gaattggcca gtttccttct     2940

ccttgtgggc catacttcaa gggatgagac tggcctttag agttagggaa gagagtggga     3000

agtaccctga ctttccattt ctgtaacaaa cacttgcagt aataaacagg taaagagcaa     3060

aggtttgttt aaacacatag ttttagactt ttgttttatt tttaatgatt ttatttggtt     3120

tatgtatatg agtgctctat ctacatgtac acctgcgtgc cagaagaggg catcagatcc     3180

cattacagat ggttgtgagt caccatgtgg tagctgggag ttgaactctg gacctctgga     3240

agagcagcca atgctcttat cttatgaacg gtctctccag cctagttttg gacttttaac     3300

ccacacactt accacaatcc tttattaggc ttatagaaag gcagcatatc atggcaagaa     3360

tatgtgatgg ctaggactgg aaaggtgcct cagtggttat gagcacatgc ctatcttgga     3420

gaggatctga cttcagttcc cagtaccctc ttctattctc ctcaggtaac tacacacaca     3480

tgcacagata tcaagcatgc atacacataa ttcaaagtaa aaattaaggc agccatgcag     3540

ccttgtaagt cttgtaatat accgccatga atttctcaga acagtggacc ttcttctttt     3600

cttctatctc ttttctaagc atgctttctc tcatgctgta gacttccttg ctctttgtcc     3660

aattatctga ctctaggcca gcttaactta acttaactta agtggcatga ctctcttccc     3720

tcatccattg tccttggagc aactgatgag gcatactgct tgcctggcct ggaagttttc     3780

tctttatcac taataaaatt atccaggagg acacaagaag aggaagaaag gaaaccaggc     3840

ccacttggca cccttccctt gtactgccga gctaggaaca cttaggatcc atcttacagc     3900

agggggacac cagcacagtg cacaggctgc ctgttccccg ttggctccat tgaaagaagc     3960

acgtgggtga ggctgaaggc agaagtaccc tctctccagt tcacccttcg gtctgtgttc     4020

tttatctctc tctgcaggag cttcgggtca tcccttgtac tcatcggttc cacaggaagt     4080

gtgtggatcc atggctactg cagcaccaca cctgccccca ctgtcggcac aaca           4134


