                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  Antibody formulation

<130>  PAT058730

<150>  US 62/931,292
<151>  2019-11-06

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Ser Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Tyr Asp Trp Val Pro Lys Ile Gly Val Phe Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Leu Tyr Ser Ser Pro 
                85                  90                  95      


Met Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Gly 
1               5                   10          


<210>  4
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Ser Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Asp Trp Val Pro Lys Ile Gly Val Phe Asp Ser 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Ala Ser Gln Phe Ile Ser Ser Ser Tyr Leu Ser 
1               5                   10          


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ser Ser Ser Arg Ala Thr 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Gln Leu Tyr Ser Ser Pro Met Thr 
1               5                   


<210>  9
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Gly Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Ser Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Tyr Asp Trp Val Pro Lys Ile Gly Val Phe Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  10
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Leu Tyr Ser Ser Pro 
                85                  90                  95      


Met Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  11
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  11
caggtgcagc tgcagcagag cggcccaggc ctggtcaagc cctctcagac cctgtcactg       60

acctgcgcca tttcaggcga cagcgtgagc agcaacagcg ccgcctgggg ctggatcagg      120

cagagccccg gtaggggcct ggaatggctg ggcaggatct actacaggtc caagtggtac      180

aacagctacg ccgtgagcgt gaagagcagg atcaccatca accctgacac cagcaagaac      240

cagttctcac tgcagctcaa cagcgtgacc cccgaggaca ccgccgtgta ctactgcgcc      300

agatacgact gggtgcccaa gatcggcgtg ttcgacagct ggggccaggg caccctggtg      360

accgtgtcaa gc                                                          372


<210>  12
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  12
gatatcgtgc tgacacagag ccccgccacc ctgagcctga gcccaggcga gagggccacc       60

ctgtcctgca gggccagcca gtttatcagc agcagctacc tgtcctggta tcagcagaag      120

cccggccagg cccctagact gctgatctac ggcagctcct ctcgggccac cggcgtgccc      180

gccaggttca gcggcagcgg ctccggcacc gacttcaccc tgacaatcag cagcctggag      240

cccgaggact tcgccgtgta ctactgccag cagctgtaca gctcacccat gaccttcggc      300

cagggcacca aggtggagat caag                                             324


<210>  13
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe Gly 
65                  70                  75                  80  


Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu Val 
                85                  90                  95      


Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser 
            100                 105                 110         


Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp 
        115                 120                 125             


Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala 
    130                 135                 140                 


Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser 
145                 150                 155                 160 


Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr 
                165                 170                 175     


Lys Thr Ala Gly Pro Glu Gln Gln 
            180                 


<210>  14
<211>  1419
<212>  DNA
<213>  Homo sapiens

<400>  14
atggcctggg tgtggaccct gcccttcctg atggccgctg cccagtcagt gcaggcccag       60

gtgcagctgc agcagagcgg cccaggcctg gtcaagccct ctcagaccct gtcactgacc      120

tgcgccattt caggcgacag cgtgagcagc aacagcgccg cctggggctg gatcaggcag      180

agccccggta ggggcctgga atggctgggc aggatctact acaggtccaa gtggtacaac      240

agctacgccg tgagcgtgaa gagcaggatc accatcaacc ctgacaccag caagaaccag      300

ttctcactgc agctcaacag cgtgaccccc gaggacaccg ccgtgtacta ctgcgccaga      360

tacgactggg tgcccaagat cggcgtgttc gacagctggg gccagggcac cctggtgacc      420

gtgtcaagcg ccagcaccaa gggccccagc gtgttccccc tggcccccag cagcaagagc      480

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg agccctgacc tccggcgtgc acaccttccc cgccgtgctg      600

cagagcagcg gcctgtacag cctgtccagc gtggtgacag tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaga      720

gtggagccca agagctgcga caagacccac acctgccccc cctgcccagc cccagagctg      780

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      840

aggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc agaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc cagagaggag      960

cagtacaaca gcacctacag ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgccagcccc catcgaaaag     1080

accatcagca aggccaaggg ccagccacgg gagccccagg tgtacaccct gcccccctcc     1140

cgggaggaga tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc     1200

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1260

cccccagtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tccaggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgtcc cccggcaag                            1419


<210>  15
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  15
atgagcgtgc tgacccaggt gctggctctg ctgctgctgt ggctgaccgg caccagatgc       60

gatatcgtgc tgacacagag ccccgccacc ctgagcctga gcccaggcga gagggccacc      120

ctgtcctgca gggccagcca gtttatcagc agcagctacc tgtcctggta tcagcagaag      180

cccggccagg cccctagact gctgatctac ggcagctcct ctcgggccac cggcgtgccc      240

gccaggttca gcggcagcgg ctccggcacc gacttcaccc tgacaatcag cagcctggag      300

cccgaggact tcgccgtgta ctactgccag cagctgtaca gctcacccat gaccttcggc      360

cagggcacca aggtggagat caagcgtacg gtggccgctc ccagcgtgtt catcttcccc      420

cccagcgacg agcagctgaa gagcggcacc gccagcgtgg tgtgcctgct gaacaacttc      480

tacccccggg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagagcg tcaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcat aaggtgtacg cctgcgaggt gacccaccag      660

ggcctgtcca gccccgtgac caagagcttc aacaggggcg agtgc                      705


