                               SEQUENCE LISTING

<110> THERMO FISHER SCIENTIFIC BALTICS UAB
 
<120> DEOXYRIBONUCLEASE VARIANTS AND USES THEREOF

<130> LT01511PCT

<140>
<141>

<150> 62/936,977
<151> 2019-11-18

<150> 62/933,215
<151> 2019-11-08

<160> 47    

<170> PatentIn version 3.5

<210> 1
<211> 260
<212> PRT
<213> Bos sp.

<400> 1
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 2
<211> 290
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Met Ala Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Ser Gly Asp Asp Asp Asp Lys Leu Lys 
            20                  25                  30          


Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met Ser Asn 
        35                  40                  45              


Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr Asp Ile 
    50                  55                  60                  


Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val Gly Lys 
65                  70                  75                  80  


Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His Tyr Val 
                85                  90                  95      


Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr Leu Phe 
            100                 105                 110         


Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln Tyr Asp 
        115                 120                 125             


Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu Pro Ala 
    130                 135                 140                 


Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe Ala Ile 
145                 150                 155                 160 


Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile Asn Ser 
                165                 170                 175     


Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu Asn Asp 
            180                 185                 190         


Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val Thr Ser 
        195                 200                 205             


Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe Gln Trp 
    210                 215                 220                 


Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn Cys Ala 
225                 230                 235                 240 


Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser Val Val 
                245                 250                 255     


Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly Leu Ser 
            260                 265                 270         


Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu Val Thr 
        275                 280                 285             


Leu Thr 
    290 


<210> 3
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (14)..(14)
<223> /replace="Arg" or "Gln" or "Asn" or "His"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 3
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Lys Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 4
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Lys Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 5
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Arg Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 6
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (44)..(44)
<223> /replace="Arg" or "Gln" or "Asn"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 6
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser Lys Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 7
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser Arg Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 8
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser Lys Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 9
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (75)..(75)
<223> /replace="Arg" or "Gln" or "Asn" or "His"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 9
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 10
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 11
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Arg Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 12
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (105)..(105)
<223> /replace="Lys" or "Gln" or "Asn" or "His"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 12
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 13
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 14
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 15
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (130)..(130)
<223> /replace="Val" or "Leu"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 15
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Met Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 16
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 17
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (138)..(138)
<223> /replace="Arg" or "Gln" or "Asn" or "His"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 17
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 18
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 19
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Arg Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 20
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (174)..(174)
<223> /replace="Arg" or "Gln" or "Asn" or "His"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 20
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Lys Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 21
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Lys Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 22
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Arg Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 23
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (177)..(177)
<223> /replace="Lys" or "Gln" or "Asn" or "His"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 23
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Arg Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 24
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Arg Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 25
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Lys Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 26
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (197)..(197)
<223> /replace="Arg" or "Asn" or "Asp" or "Cys" or "Glu"
      or "Gln" or "Gly" or "His" or "Ile" or "Leu" or "Lys" 
      or "Met" or "Phe" or "Pro" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"
	
<400> 26
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 27
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 28
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (205)..(205)
<223> /replace="Lys" or "Gln" or "Asn" or "His"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 28
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Arg Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 29
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Arg Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 30
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Lys Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 31
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Arg" or "Asn" or "Asp" or "Cys" or "Glu"
      or "Gln" or "Gly" or "His" or "Ile" or "Leu" or "Lys" 
      or "Met" or "Phe" or "Pro" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221> SITE
<222> (1)..(260)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 31
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 32
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 33
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Gly Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Arg Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 34
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Ser Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Ser Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Ser Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 35
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Lys Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Lys Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 36
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser Arg Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Ile Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Lys Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 37
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Lys Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Lys Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Arg Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Pro Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 38
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Lys Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser His Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Lys Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 39
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser Arg Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Lys Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Arg Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 40
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser Arg Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Lys Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 41
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser Arg Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Arg Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr 
            260 


<210> 42
<211> 345
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Leu Lys Ile Ala Ala Phe Asn Ile Arg Thr Phe Gly Glu Thr Lys Met 
1               5                   10                  15      


Ser Asn Ala Thr Leu Ala Ser Tyr Ile Val Arg Ile Val Arg Arg Tyr 
            20                  25                  30          


Asp Ile Val Leu Ile Gln Glu Val Arg Asp Ser Arg Leu Val Ala Val 
        35                  40                  45              


Gly Lys Leu Leu Asp Tyr Leu Asn Gln Asp Asp Pro Asn Thr Tyr His 
    50                  55                  60                  


Tyr Val Val Ser Glu Pro Leu Gly Arg Asn Lys Tyr Lys Glu Arg Tyr 
65                  70                  75                  80  


Leu Phe Leu Phe Arg Pro Asn Lys Val Ser Val Leu Asp Thr Tyr Gln 
                85                  90                  95      


Tyr Asp Asp Gly Cys Glu Ser Cys Arg Asn Asp Ser Phe Ser Arg Glu 
            100                 105                 110         


Pro Ala Val Val Lys Phe Ser Ser His Ser Thr Lys Val Lys Glu Phe 
        115                 120                 125             


Ala Leu Val Ala Leu His Ser Ala Pro Lys Asp Ala Val Ala Glu Ile 
    130                 135                 140                 


Asn Ser Leu Tyr Asp Val Tyr Leu Asp Val Gln Gln Lys Trp His Leu 
145                 150                 155                 160 


Asn Asp Val Met Leu Met Gly Asp Phe Asn Ala Asp Cys Arg Tyr Val 
                165                 170                 175     


Thr Ser Ser Gln Trp Ser Ser Ile Arg Leu Arg Thr Ser Ser Thr Phe 
            180                 185                 190         


Gln Trp Leu Ile Ser Asp Ser Ala Asp Thr Thr Ala Thr Ser Thr Asn 
        195                 200                 205             


Cys Ala Tyr Asp Arg Ile Val Val Ala Gly Ser Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Val Ser Gly Ser Ala Ala Pro Phe Asp Phe Gln Ala Ala Tyr Gly 
225                 230                 235                 240 


Leu Ser Asn Glu Met Ala Leu Ala Ile Ser Asp His Tyr Pro Val Glu 
                245                 250                 255     


Val Thr Leu Thr Gly Glu Glu Thr Ala Val Gln Gln Gly Gly Gly Gly 
            260                 265                 270         


Ser Val Gln Ser Asp Gly Gly Lys Gly Ala Leu Val Asn Ile Asn Thr 
        275                 280                 285             


Ala Thr Leu Glu Glu Leu Gln Gly Ile Ser Gly Val Gly Pro Ser Lys 
    290                 295                 300                 


Ala Glu Ala Ile Ile Ala Tyr Arg Glu Glu Asn Gly Arg Phe Gln Thr 
305                 310                 315                 320 


Ile Glu Asp Ile Thr Lys Val Ser Gly Ile Gly Glu Lys Ser Phe Glu 
                325                 330                 335     


Lys Ile Lys Ser Ser Ile Thr Val Lys 
            340                 345 


<210> 43
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 43
gttggtgggt ttgggtgtgg gtttgtgttt                                        30


<210> 44
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 44
aaacacaaac ccacacccaa acccaccaac                                        30


<210> 45
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 45
tgatgacggt gaaaacctct ga                                                22


<210> 46
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 46
cggcatccgc ttacagaca                                                    19


<210> 47
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 47
His His His His His His 
1               5       



