                         SEQUENCE LISTING

<110>  Monash University
 
<120>  CYTOKINE OR GROWTH FACTOR FUSION PROTEINS

<130>  P112248.PCT

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  3
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  3

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  4
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210>  5
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
1               5                   10                  15      


Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
            20                  25                  30          


Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
        35                  40                  45              


Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
    50                  55                  60                  


Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
                85                  90                  95      


Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
            100                 105                 110         


Lys Glu Thr Thr Ala Ala Gly Asp Ser 
        115                 120     


<210>  6
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Phe Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp 
1               5                   10                  15      


Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu 
            20                  25                  30          


Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser 
        35                  40                  45              


Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys 
    50                  55                  60                  


Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly 
65                  70                  75                  80  


Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys 
                85                  90                  95      


Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His 
            100                 105                 110         


Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn 
        115                 120                 125             


Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val 
    130                 135                 140                 


Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser 
145                 150                 155                 160 


Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
                165                 170                 175     


<210>  7
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  7

Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln Leu Gln 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile Phe Ser 
            20                  25                  30          


Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg Phe His 
        35                  40                  45              


Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala Val Arg 
    50                  55                  60                  


Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu Thr Asp 
65                  70                  75                  80  


Tyr Gly Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr Ala Thr Met Ser 
                85                  90                  95      


Leu 
    


<210>  8
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Pro Val Val Arg Lys Gly Arg Cys Ser Cys Ile Ser Thr Asn Gln 
1               5                   10                  15      


Gly Thr Ile His Leu Gln Ser Leu Lys Asp Leu Lys Gln Phe Ala Pro 
            20                  25                  30          


Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile Ala Thr Leu Lys Asn Gly 
        35                  40                  45              


Val Gln Thr Cys Leu Asn Pro Asp Ser Ala Asp Val Lys Glu Leu Ile 
    50                  55                  60                  


Lys Lys Trp Glu Lys Gln Val Ser Gln Lys Lys Lys Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Lys His Gln Lys Lys Lys Val Leu Lys Val Arg Lys Ser Gln Arg 
                85                  90                  95      


Ser Arg Gln Lys Lys Thr Thr 
            100             


<210>  9
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys Ile Ser Ile Ser Asn 
1               5                   10                  15      


Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu Glu Ile Ile Pro Ala 
            20                  25                  30          


Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala Thr Met Lys Lys Lys 
        35                  40                  45              


Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys Ala Ile Lys Asn Leu 
    50                  55                  60                  


Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg Ser Pro 
65                  70                  75          


<210>  10
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys Arg Phe Lys Met 
65                  70          


<210>  11
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser Val Thr Gln Lys Pro 
1               5                   10                  15      


Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr Leu Leu Ile Lys Asp 
            20                  25                  30          


Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr Leu Arg Gly Arg Gln 
        35                  40                  45              


Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu Arg Ile Ile Gln Arg 
    50                  55                  60                  


Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg Ser Ser 
65                  70                  75          


<210>  12
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Ser Asn Phe Asp Cys Cys Leu Gly Tyr Thr Asp Arg Ile Leu His 
1               5                   10                  15      


Pro Lys Phe Ile Val Gly Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys 
            20                  25                  30          


Asp Ile Asn Ala Ile Ile Phe His Thr Lys Lys Lys Leu Ser Val Cys 
        35                  40                  45              


Ala Asn Pro Lys Gln Thr Trp Val Lys Tyr Ile Val Arg Leu Leu Ser 
    50                  55                  60                  


Lys Lys Val Lys Asn Met 
65                  70  


<210>  13
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Pro Tyr Gly Ala Asn Met Glu Asp Ser Val Cys Cys Arg Asp Tyr 
1               5                   10                  15      


Val Arg Tyr Arg Leu Pro Leu Arg Val Val Lys His Phe Tyr Trp Thr 
            20                  25                  30          


Ser Asp Ser Cys Pro Arg Pro Gly Val Val Leu Leu Thr Phe Arg Asp 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Arg Val Pro Trp Val Lys Met Ile Leu 
    50                  55                  60                  


Asn Lys Leu Ser Gln 
65                  


<210>  14
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
1               5                   10                  15      


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                  25                  30          


Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp 
        35                  40                  45              


Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser 
    50                  55                  60                  


Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu 
                85                  90                  95      


Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr 
            100                 105                 110         


Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
        115                 120                 125             


Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
    130                 135                 140                 


Lys Ser 
145     


<210>  15
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  15

Phe Ala Val Ser Gln Gly Ile Val Gly Ile Arg Gly Val Phe Ser Asn 
1               5                   10                  15      


Lys Phe Leu Ala Met Ser Lys Lys Gly Lys Leu His Ala Ser Ala Lys 
            20                  25                  30          


Phe Thr Asp Asp Cys Lys Phe Arg Glu Arg Phe Gln Glu Asn Ser Tyr 
        35                  40                  45              


Asn Thr Tyr Ala Ser Ala Ile His Arg Thr Glu Lys Thr Gly Arg Glu 
    50                  55                  60                  


Trp Tyr Val Ala Leu Asn Lys Arg Gly Lys Ala Lys Arg Gly Cys Ser 
65                  70                  75                  80  


Pro Arg Val Lys Pro Gln His Ile Ser Thr His Phe Leu Pro Arg Phe 
                85                  90                  95      


Lys Gln Ser Glu Gln Pro Glu Leu Ser Phe Thr Val Thr Val Pro Glu 
            100                 105                 110         


Lys Lys Lys Pro Pro Ser Pro Ile Lys Pro Lys Ile Pro Leu Ser Ala 
        115                 120                 125             


Pro Arg Lys Asn Thr Asn Ser Val Lys Tyr Arg Leu Lys Phe Arg Phe 
    130                 135                 140                 


Gly 
145 


<210>  16
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Asn Asn Tyr Asn Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile 
1               5                   10                  15      


Val Ala Ile Lys Gly Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys 
            20                  25                  30          


Glu Gly Lys Leu Tyr Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe 
        35                  40                  45              


Lys Glu Leu Ile Leu Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys 
    50                  55                  60                  


Trp Thr His Asn Gly Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly 
65                  70                  75                  80  


Ile Pro Val Arg Gly Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His 
                85                  90                  95      


Phe Leu Pro Met Ala Ile Thr 
            100             


<210>  17
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu Ala Thr Asn Ser Ser 
1               5                   10                  15      


Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly Arg His Val Arg Ser 
            20                  25                  30          


Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg Lys Leu Phe Ser Phe 
        35                  40                  45              


Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly Lys Val Ser Gly Thr 
    50                  55                  60                  


Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu Ile Thr Ser Val Glu 
65                  70                  75                  80  


Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser Asn Tyr Tyr Leu Ala 
                85                  90                  95      


Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys Glu Phe Asn Asn Asp 
            100                 105                 110         


Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn Gly Tyr Asn Thr Tyr Ala 
        115                 120                 125             


Ser Phe Asn Trp Gln His Asn Gly Arg Gln Met Tyr Val Ala Leu Asn 
    130                 135                 140                 


Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys Thr Arg Arg Lys Asn Thr 
145                 150                 155                 160 


Ser Ala His Phe Leu Pro Met Val Val His Ser 
                165                 170     


<210>  18
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Glu Asn Val Asp Phe Arg Ile His Val Glu Asn Gln Thr Arg Ala 
1               5                   10                  15      


Arg Asp Asp Val Ser Arg Lys Gln Leu Arg Leu Tyr Gln Leu Tyr Ser 
            20                  25                  30          


Arg Thr Ser Gly Lys His Ile Gln Val Leu Gly Arg Arg Ile Ser Ala 
        35                  40                  45              


Arg Gly Glu Asp Gly Asp Lys Tyr Ala Gln Leu Leu Val Glu Thr Asp 
    50                  55                  60                  


Thr Phe Gly Ser Gln Val Arg Ile Lys Gly Lys Glu Thr Glu Phe Tyr 
65                  70                  75                  80  


Leu Cys Met Asn Arg Lys Gly Lys Leu Val Gly Lys Pro Asp Gly Thr 
                85                  90                  95      


Ser Lys Glu Cys Val Phe Ile Glu Lys Val Leu Glu Asn Asn Tyr Thr 
            100                 105                 110         


Ala Leu Met Ser Ala Lys Tyr Ser Gly Trp Tyr Val Gly Phe Thr Lys 
        115                 120                 125             


Lys Gly Arg Pro Arg Lys Gly Pro Lys Thr Arg Glu Asn Gln Gln Asp 
    130                 135                 140                 


Val His Phe Met Lys Arg Tyr Pro Lys Gly Gln Pro Glu Leu Gln Lys 
145                 150                 155                 160 


Pro Phe Lys Tyr Thr Thr Val Thr Lys Arg Ser Arg Arg Ile Arg Pro 
                165                 170                 175     


Thr His Pro Ala 
            180 


<210>  19
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys 
        115                 120                 125             


Arg Lys Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg 
    130                 135                 140                 


Cys Cys Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro 
145                 150                 155                 160 


Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys 
                165                 170                 175     


Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu 
            180                 185                 190         


Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
        195                 200                 205     


<210>  20
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Cys Asp Lys 
    130                 135                 140                 


Pro Arg Arg 
145         


<210>  21
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  21

Pro Val Ser Gln Pro Asp Ala Pro Gly His Gln Arg Lys Val Val Ser 
1               5                   10                  15      


Trp Ile Asp Val Tyr Thr Arg Ala Thr Cys Gln Pro Arg Glu Val Val 
            20                  25                  30          


Val Pro Leu Thr Val Glu Leu Met Gly Thr Val Ala Lys Gln Leu Val 
        35                  40                  45              


Pro Ser Cys Val Thr Val Gln Arg Cys Gly Gly Cys Cys Pro Asp Asp 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Gly Gln His Gln Val Arg Met Gln Ile 
65                  70                  75                  80  


Leu Met Ile Arg Tyr Pro Ser Ser Gln Leu Gly Glu Met Ser Leu Glu 
                85                  90                  95      


Glu His Ser Gln Cys Glu Cys Arg Pro Lys Lys Lys Asp Ser Ala Val 
            100                 105                 110         


Lys Pro Asp Arg Ala Ala Thr Pro His His Arg Pro Gln Pro Arg Ser 
        115                 120                 125             


Val Pro Gly Trp Asp Ser Ala Pro Gly Ala Pro Ser Pro Ala Asp Ile 
    130                 135                 140                 


Thr His Pro Thr Pro Ala Pro Gly Pro Ser Ala His Ala Ala Pro Ser 
145                 150                 155                 160 


Thr Thr Ser Ala Leu Thr Pro Gly Pro Ala Ala Ala Ala Ala Asp Ala 
                165                 170                 175     


Ala Ala Ser Ser Val Ala Lys Gly Gly Ala 
            180                 185     


<210>  22
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala His Tyr Asn Thr Glu Ile Leu Lys Ser Ile Asp Asn Glu Trp Arg 
1               5                   10                  15      


Lys Thr Gln Cys Met Pro Arg Glu Val Cys Ile Asp Val Gly Lys Glu 
            20                  25                  30          


Phe Gly Val Ala Thr Asn Thr Phe Phe Lys Pro Pro Cys Val Ser Val 
        35                  40                  45              


Tyr Arg Cys Gly Gly Cys Cys Asn Ser Glu Gly Leu Gln Cys Met Asn 
    50                  55                  60                  


Thr Ser Thr Ser Tyr Leu Ser Lys Thr Leu Phe Glu Ile Thr Val Pro 
65                  70                  75                  80  


Leu Ser Gln Gly Pro Lys Pro Val Thr Ile Ser Phe Ala Asn His Thr 
                85                  90                  95      


Ser Cys Arg Cys Met Ser Lys Leu Asp Val Tyr Arg Gln Val His Ser 
            100                 105                 110         


Ile Ile Arg Arg 
        115     


<210>  23
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Cys Gly Asp 
    130                 135                 140                 


Ala Val Pro Arg Arg 
145                 


<210>  24
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Arg Arg Pro 
    130                 135                 140                 


Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro Thr Asp Cys 
145                 150                 155                 160 


His Leu Cys Gly Asp Ala Val Pro Arg Arg 
                165                 170 


<210>  25
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      


Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          


Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              


Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  


Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  


Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      


Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         


Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             


Glu Cys Arg His Ser Pro Gly Arg Gln Ser Pro Asp Met Pro Gly Asp 
    130                 135                 140                 


Phe Arg Ala Asp Ala Pro Ser Phe Leu Pro Pro Arg Arg Ser Leu Pro 
145                 150                 155                 160 


Met Leu Phe Arg Met Glu Trp Gly Cys Ala Leu Thr Gly Ser Gln Ser 
                165                 170                 175     


Ala Val Trp Pro Ser Ser Pro Val Pro Glu Glu Ile Pro Arg Met His 
            180                 185                 190         


Pro Gly Arg Asn Gly Lys Lys Gln Gln Arg Lys Pro Leu Arg Glu Lys 
        195                 200                 205             


Met Lys Pro Glu Arg Arg Arg Pro Lys Gly Arg Gly Lys Arg Arg Arg 
    210                 215                 220                 


Glu Lys Gln Arg Pro Thr Asp Cys His Leu Cys Gly Asp Ala Val Pro 
225                 230                 235                 240 


Arg Arg 
        


<210>  26
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Ile Glu Glu Ala Val Pro Ala Val Cys Lys Thr Arg Thr Val Ile 
1               5                   10                  15      


Tyr Glu Ile Pro Arg Ser Gln Val Asp Pro Thr Ser Ala Asn Phe Leu 
            20                  25                  30          


Ile Trp Pro Pro Cys Val Glu Val Lys Arg Cys Thr Gly Cys Cys Asn 
        35                  40                  45              


Thr Ser Ser Val Lys Cys Gln Pro Ser Arg Val His His Arg Ser Val 
    50                  55                  60                  


Lys Val Ala Lys Val Glu Tyr Val Arg Lys Lys Pro Lys Leu Lys Glu 
65                  70                  75                  80  


Val Gln Val Arg Leu Glu Glu His Leu Glu Cys Ala Cys Ala Thr Thr 
                85                  90                  95      


Ser Leu Asn Pro Asp Tyr Arg Glu Glu Asp Thr Gly Arg Pro Arg Glu 
            100                 105                 110         


Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu Lys Pro Thr 
        115                 120                 125 


<210>  27
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  27

Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu Cys 
1               5                   10                  15      


Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg 
            20                  25                  30          


Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg 
        35                  40                  45              


Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr Gln 
    50                  55                  60                  


Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys 
65                  70                  75                  80  


Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala 
                85                  90                  95      


Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr 
            100                 105                 


<210>  28
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe Ser Ser Asn Lys Glu Gln 
1               5                   10                  15      


Asn Gly Val Gln Asp Pro Gln His Glu Arg Ile Ile Thr Val Ser Thr 
            20                  25                  30          


Asn Gly Ser Ile His Ser Pro Arg Phe Pro His Thr Tyr Pro Arg Asn 
        35                  40                  45              


Thr Val Leu Val Trp Arg Leu Val Ala Val Glu Glu Asn Val Trp Ile 
    50                  55                  60                  


Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu Glu Asp Pro Glu Asp Asp 
65                  70                  75                  80  


Ile Cys Lys Tyr Asp Phe Val Glu Val Glu Glu Pro Ser Asp Gly Thr 
                85                  90                  95      


Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr Val Pro Gly Lys Gln Ile 
            100                 105                 110         


Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe Val Ser Asp Glu Tyr Phe 
        115                 120                 125             


Pro Ser Glu Pro Gly Phe Cys Ile His Tyr Asn Ile Val Met Pro Gln 
    130                 135                 140                 


Phe Thr Glu Ala Val Ser Pro Ser Val Leu Pro Pro Ser Ala Leu Pro 
145                 150                 155                 160 


Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala Phe Ser Thr Leu Glu Asp 
                165                 170                 175     


Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp Gln Leu Asp Leu Glu Asp 
            180                 185                 190         


Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly Lys Ala Phe Val Phe Gly 
        195                 200                 205             


Arg Lys Ser Arg Val Val Asp Leu Asn Leu Leu Thr Glu Glu Val Arg 
    210                 215                 220                 


Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser Val Ser Ile Arg Glu Glu 
225                 230                 235                 240 


Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro Gly Cys Leu Leu Val Lys 
                245                 250                 255     


Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu His Asn Cys Asn Glu Cys 
            260                 265                 270         


Gln Cys Val Pro Ser Lys Val Thr Lys Lys Tyr His Glu Val Leu Gln 
        275                 280                 285             


Leu Arg Pro Lys Thr Gly Val Arg Gly Leu His Lys Ser Leu Thr Asp 
    290                 295                 300                 


Val Ala Leu Glu His His Glu Glu Cys Asp Cys Val Cys Arg Gly Ser 
305                 310                 315                 320 


Thr Gly Gly 
            


<210>  29
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Asp Thr Ser Ala Thr Pro Gln Ser Ala Ser Ile Lys Ala Leu Arg 
1               5                   10                  15      


Asn Ala Asn Leu Arg Arg Asp Glu Ser Asn His Leu Thr Asp Leu Tyr 
            20                  25                  30          


Arg Arg Asp Glu Thr Ile Gln Val Lys Gly Asn Gly Tyr Val Gln Ser 
        35                  40                  45              


Pro Arg Phe Pro Asn Ser Tyr Pro Arg Asn Leu Leu Leu Thr Trp Arg 
    50                  55                  60                  


Leu His Ser Gln Glu Asn Thr Arg Ile Gln Leu Val Phe Asp Asn Gln 
65                  70                  75                  80  


Phe Gly Leu Glu Glu Ala Glu Asn Asp Ile Cys Arg Tyr Asp Phe Val 
                85                  90                  95      


Glu Val Glu Asp Ile Ser Glu Thr Ser Thr Ile Ile Arg Gly Arg Trp 
            100                 105                 110         


Cys Gly His Lys Glu Val Pro Pro Arg Ile Lys Ser Arg Thr Asn Gln 
        115                 120                 125             


Ile Lys Ile Thr Phe Lys Ser Asp Asp Tyr Phe Val Ala Lys Pro Gly 
    130                 135                 140                 


Phe Lys Ile Tyr Tyr Ser Leu Leu Glu Asp Phe Gln Pro Ala Ala Ala 
145                 150                 155                 160 


Ser Glu Thr Asn Trp Glu Ser Val Thr Ser Ser Ile Ser Gly Val Ser 
                165                 170                 175     


Tyr Asn Ser Pro Ser Val Thr Asp Pro Thr Leu Ile Ala Asp Ala Leu 
            180                 185                 190         


Asp Lys Lys Ile Ala Glu Phe Asp Thr Val Glu Asp Leu Leu Lys Tyr 
        195                 200                 205             


Phe Asn Pro Glu Ser Trp Gln Glu Asp Leu Glu Asn Met Tyr Leu Asp 
    210                 215                 220                 


Thr Pro Arg Tyr Arg Gly Arg Ser Tyr His Asp Arg Lys Ser Lys Val 
225                 230                 235                 240 


Asp Leu Asp Arg Leu Asn Asp Asp Ala Lys Arg Tyr Ser Cys Thr Pro 
                245                 250                 255     


Arg Asn Tyr Ser Val Asn Ile Arg Glu Glu Leu Lys Leu Ala Asn Val 
            260                 265                 270         


Val Phe Phe Pro Arg Cys Leu Leu Val Gln Arg Cys Gly Gly Asn Cys 
        275                 280                 285             


Gly Cys Gly Thr Val Asn Trp Arg Ser Cys Thr Cys Asn Ser Gly Lys 
    290                 295                 300                 


Thr Val Lys Lys Tyr His Glu Val Leu Gln Phe Glu Pro Gly His Ile 
305                 310                 315                 320 


Lys Arg Arg Gly Arg Ala Lys Thr Met Ala Leu Val Asp Ile Gln Leu 
                325                 330                 335     


Asp His His Glu Arg Cys Asp Cys Ile Cys Ser Ser Arg Pro Pro Arg 
            340                 345                 350         


<210>  30
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  30

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  31
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Leu Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser 
1               5                   10                  15      


Lys Pro Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg 
            20                  25                  30          


Lys Lys Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg 
        35                  40                  45              


Lys Tyr Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu 
    50                  55                  60                  


Leu Arg Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg 
65                  70                  75                  80  


Cys His Gly Leu Ser Leu 
                85      


<210>  32
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln Asn Lys Thr Glu 
1               5                   10                  15      


Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys Lys Gly Gly Lys 
            20                  25                  30          


Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn Pro Cys Asn Ala 
        35                  40                  45              


Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys Tyr Ile Glu His 
    50                  55                  60                  


Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr Phe Gly Glu Arg 
65                  70                  75                  80  


Cys Gly Glu Lys Ser Met Lys 
                85          


<210>  33
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  33

Val Ser Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His 
1               5                   10                  15      


Gly Gln Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys 
            20                  25                  30          


Glu Val Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu 
        35                  40                  45      


<210>  34
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  34

Cys Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala 
1               5                   10                  15      


Pro Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly 
            20                  25                  30          


Ser Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala 
        35                  40                  45              


Leu Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln 
    50                  55                  60                  


Arg Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn 
65                  70                  75                  80  


Gln Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe 
                85                  90                  95      


Lys Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys 
            100                 105                 110         


Glu Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu 
        115                 120                 125             


Lys Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu 
    130                 135                 140                 


Lys Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe 
145                 150                 155                 160 


Lys Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr 
                165                 170                 175     


Gly Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val 
            180                 185                 190         


Glu Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys 
        195                 200                 205             


Asp Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu 
    210                 215                 220                 


Ser Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser 
225                 230                 235                 240 


Tyr Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln 
                245                 250                 255     


Leu Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu 
            260                 265                 270         


Lys Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys Ala Glu 
        275                 280                 285             


Glu Leu Tyr Gln Lys 
    290             


<210>  35
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  36
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  37
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  38
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  39
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  40
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
1               5                   10                  15      


His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
            20                  25                  30          


Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  


Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
65                  70                  75                  80  


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
                85                  90                  95      


Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
            100                 105                 110         


Cys Arg 
        


<210>  41
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  41

Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      


Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser 
            20                  25                  30          


Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              


Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro 
                85                  90                  95      


Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile 
            100                 105                 110         


Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             


Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 


<210>  42
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys 
            20                  25                  30          


Gly Lys Glu Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val 
        35                  40                  45              


Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val 
    50                  55                  60                  


Asp Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
65                  70                  75                  80  


Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln 
                85                  90                  95      


Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val Leu 
            100                 105                 110         


Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120 


<210>  43
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  43

Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Asp Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Arg Lys Ile Gly Arg Thr 
        115                 


<210>  44
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  44

His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210>  45
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr Ser Ser 
1               5                   10                  15      


Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu Val Pro 
            20                  25                  30          


Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro Ser Val 
        35                  40                  45              


Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln Phe Arg 
    50                  55                  60                  


Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala Ile Phe 
65                  70                  75                  80  


Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val His Ala 
                85                  90                  95      


Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys Ala Glu 
            100                 105                 110         


Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly Ser Pro 
        115                 120                 125             


Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu Phe Gly 
    130                 135                 140                 


Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg Pro Asp 
145                 150                 155                 160 


Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg Gln Ala 
                165                 170                 175     


Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu Ser Gly 
            180                 185                 190         


Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe Arg Ala 
        195                 200                 205             


Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu Met Val 
    210                 215                 220                 


Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu Arg Pro 
225                 230                 235                 240 


Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val Tyr Tyr 
                245                 250                 255     


Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly Ser Phe 
            260                 265                 270         


Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile Asp Gly 
        275                 280                 285             


Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala Glu Arg 
    290                 295                 300                 


Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr Val Ser 
305                 310                 315                 320 


Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
                325                 330                 


<210>  46
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  46

Arg Lys Arg Leu Gln Val Gln Leu Ser Ile Arg Thr 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Rattus rattus

<400>  47

Arg Lys Arg Leu Gln Val Gln Leu Asn Ile Arg Thr 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Equus caballus

<400>  48

Arg Lys Arg Leu Ser Val Gln Leu Ser Leu Arg Thr 
1               5                   10          


<210>  49
<211>  11
<212>  PRT
<213>  Felis catus

<400>  49

Lys Arg Leu Gln Val Gln Leu Asn Ile Arg Thr 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Canus lupus

<400>  50

Lys Arg Leu Ser Val Gln Leu Ser Ile Arg Thr 
1               5                   10      


<210>  51
<211>  12
<212>  PRT
<213>  Sus scrofa

<400>  51

Arg Arg Arg Leu Ser Val Gln Leu Ser Ile Arg Thr 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Macaca fascicularis

<400>  52

Arg Lys Arg Leu Ser Val Glu Leu Ser Ile Arg Thr 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  53

Arg Lys Lys Leu Ser Val Glu Leu Ser Ile Arg Thr 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (5)..(7)
<223>  Y, C, Q, T, N, or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Y, C, Q, T, N, or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  K or R

<400>  54

Xaa Xaa Xaa Leu Xaa Xaa Xaa Leu Xaa Ile Xaa Thr 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  55

Thr Leu Phe Leu Ala His Gly Arg Leu Val Tyr Met 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  G, Y, C, Q, T, N, or S

<400>  56

Thr Leu Phe Leu Ala His Gly Xaa Leu Val Xaa Met 
1               5                   10          


<210>  57
<211>  19
<212>  PRT
<213>  Homo sapiens or Mus musculus

<400>  57

Lys Asn Ser Phe Met Ala Leu Tyr Leu Ser Lys Gly Arg Leu Val Phe 
1               5                   10                  15      


Ala Leu Gly 
            


<210>  58
<211>  12
<212>  PRT
<213>  Homo sapiens or Mus musculus

<400>  58

Lys Asn Ser Phe Met Ala Leu Tyr Leu Ser Lys Gly 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  K or R

<400>  59

Xaa Asn Ser Phe Met Ala Leu Tyr Leu Ser Xaa Gly 
1               5                   10          


<210>  60
<211>  19
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<400>  60

Xaa Asn Ser Phe Met Ala Leu Tyr Leu Ser Xaa Gly Xaa Leu Val Phe 
1               5                   10                  15      


Ala Leu Gly 
            


<210>  61
<211>  12
<212>  PRT
<213>  Homo sapiens or Mus musculus

<400>  61

Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  K or R

<400>  62

Leu Ala Ile Xaa Asn Asp Asn Leu Val Tyr Val Tyr 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Homo sapiens or Mus musculus

<400>  63

Asp Val Ile Ser Leu Tyr Asn Phe Lys His Ile Tyr 
1               5                   10          


<210>  64
<211>  12
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  K or R

<400>  64

Asp Val Ile Ser Leu Tyr Asn Phe Xaa His Ile Tyr 
1               5                   10          


<210>  65
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  65

Gly Leu Ile Tyr Tyr Val Ala His Gln Asn Gln Met 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  A, V, L, I, P, F, M, W, or G

<400>  66

Gly Leu Ile Tyr Tyr Xaa Ala His Gln Asn Gln Met 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  67

Lys Ala Phe Asp Ile Thr Tyr Val Arg Leu Lys Phe 
1               5                   10          


<210>  68
<211>  12
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  K or R

<400>  68

Xaa Ala Phe Asp Ile Thr Tyr Val Xaa Leu Xaa Phe 
1               5                   10          


<210>  69
<211>  19
<212>  PRT
<213>  Homo sapiens or Mus musculus

<400>  69

Asp Phe Leu Ala Val Glu Met Arg Arg Gly Lys Val Ala Phe Leu Trp 
1               5                   10                  15      


Asp Leu Gly 
            


<210>  70
<211>  19
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  A, V, L, I, P, F, M, W, or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Y, C, Q, T, N, S, A, V, L, I, P, F, M, W, or G

<400>  70

Asp Phe Leu Ala Xaa Glu Met Xaa Xaa Gly Xaa Val Xaa Phe Leu Trp 
1               5                   10                  15      


Asp Leu Gly 
            


<210>  71
<211>  20
<212>  PRT
<213>  Homo sapiens or Mus musculus

<400>  71

Lys Glu Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val 
1               5                   10                  15      


Tyr Asn Leu Gly 
            20  


<210>  72
<211>  20
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  K or R

<400>  72

Xaa Glu Tyr Met Gly Leu Ala Ile Xaa Asn Asp Asn Leu Val Tyr Val 
1               5                   10                  15      


Tyr Asn Leu Gly 
            20  


<210>  73
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  73

Asp Phe Leu Ser Ile Glu Leu Phe Arg Gly Arg Val Lys Val Met Thr 
1               5                   10                  15      


Asp Leu Gly 
            


<210>  74
<211>  19
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  K or R

<400>  74

Asp Phe Leu Ser Ile Glu Leu Phe Xaa Gly Xaa Val Xaa Val Met Thr 
1               5                   10                  15      


Asp Leu Gly 
            


<210>  75
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  75

Ala Tyr Tyr Ala Ile Phe Leu Asn Lys Gly Arg Leu Glu Val His Leu 
1               5                   10                  15      


Ser Ser Gly 
            


<210>  76
<211>  19
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  K or R

<400>  76

Ala Tyr Tyr Ala Ile Phe Leu Asn Xaa Gly Xaa Leu Glu Val His Leu 
1               5                   10                  15      


Ser Ser Gly 
            


<210>  77
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  77

Asp Phe Met Thr Leu Phe Leu Ala His Gly Arg Leu Val Phe Met Phe 
1               5                   10                  15      


Asn Val Gly 
            


<210>  78
<211>  19
<212>  PRT
<213>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  K or R

<400>  78

Asp Phe Met Thr Leu Phe Leu Ala His Gly Xaa Leu Val Phe Met Phe 
1               5                   10                  15      


Asn Val Gly 
            


<210>  79
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  79

Asn Gln Glu Gln Val Ser Pro Leu Gly Pro Gln Gly Ile Trp Gly Gln 
1               5                   10                  15      


Ser Leu Gly Ser Leu Ala Ala Ala Glu Pro Ala Val Ile Ala Glu Cys 
            20                  25                  30          


Lys Thr Arg Thr Glu Val Phe Gln Ile Ser Arg Asn Leu Ile Asp Arg 
        35                  40                  45              


Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg 
    50                  55                  60                  


Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Ala Ser Gln 
65                  70                  75                  80  


Val Gln Met Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys 
                85                  90                  95      


Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala 
            100                 105                 110         


Cys Lys Cys Glu Thr Ile Val Thr Pro Arg Pro Val Thr Ala Gly Ser 
        115                 120                 125             


Gly Gly Ser Arg Lys Arg Leu Gln Val Gln Leu Ser Ile Arg Thr 
    130                 135                 140             


<210>  80
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  80

Asn Gln Glu Gln Val Ser Pro Leu Gly Pro Gln Gly Ile Trp Gly Gln 
1               5                   10                  15      


Ala Ser Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val 
            20                  25                  30          


Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu 
        35                  40                  45              


Thr Leu Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile 
    50                  55                  60                  


Phe Lys Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
65                  70                  75                  80  


Asp Glu Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met 
                85                  90                  95      


Gln Ile Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met 
            100                 105                 110         


Ser Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg 
        115                 120                 125             


Ala Arg Gln Glu Asn Cys Asp Lys Pro Arg Arg Ala Gly Ser Gly Gly 
    130                 135                 140                 


Ser Arg Lys Arg Leu Gln Val Gln Leu Ser Ile Arg Thr 
145                 150                 155         


<210>  81
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Ser Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val 
1               5                   10                  15      


Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu 
            20                  25                  30          


Thr Leu Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile 
        35                  40                  45              


Phe Lys Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
    50                  55                  60                  


Asp Glu Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met 
65                  70                  75                  80  


Gln Ile Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met 
                85                  90                  95      


Ser Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg 
            100                 105                 110         


Ala Arg Gln Glu Asn Cys Asp Lys Pro Arg Arg Ala Gly Ser Gly Gly 
        115                 120                 125             


Ser Arg Lys Arg Leu Gln Val Gln Leu Ser Ile Arg Thr 
    130                 135                 140     


<210>  82
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  82

Asn Gln Glu Gln Val Ser Pro Leu Gly Pro Gln Gly Ile Trp Gly Gln 
1               5                   10                  15      


Ser Leu Gly Ser Leu Ala Ala Ala Glu Pro Ala Val Ile Ala Glu Cys 
            20                  25                  30          


Lys Thr Arg Thr Glu Val Phe Gln Ile Ser Arg Asn Leu Ile Asp Arg 
        35                  40                  45              


Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg 
    50                  55                  60                  


Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Ala Ser Gln 
65                  70                  75                  80  


Val Gln Met Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys 
                85                  90                  95      


Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala 
            100                 105                 110         


Cys Lys Cys Glu Thr Ile Val Thr Pro Arg Pro Val Thr 
        115                 120                 125 


<210>  83
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  83

Asn Gln Glu Gln Val Ser Pro Leu Gly Pro Gln Gly Ile Trp Gly Gln 
1               5                   10                  15      


Ala Ser Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val 
            20                  25                  30          


Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu 
        35                  40                  45              


Thr Leu Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile 
    50                  55                  60                  


Phe Lys Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
65                  70                  75                  80  


Asp Glu Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met 
                85                  90                  95      


Gln Ile Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met 
            100                 105                 110         


Ser Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg 
        115                 120                 125             


Ala Arg Gln Glu Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His 
    130                 135                 140                 


Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr 
145                 150                 155                 160 


Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys 
                165                 170                 175     


Arg Cys Asp Lys Pro Arg Arg 
            180             


<210>  84
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  84

Asn Gln Glu Gln Val Ser Pro Leu Gly Pro Gln Gly Ile Trp Gly Gln 
1               5                   10                  15      


Ala Ser Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val 
            20                  25                  30          


Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu 
        35                  40                  45              


Thr Leu Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile 
    50                  55                  60                  


Phe Lys Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn 
65                  70                  75                  80  


Asp Glu Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met 
                85                  90                  95      


Gln Ile Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met 
            100                 105                 110         


Ser Phe Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg 
        115                 120                 125             


Ala Arg Gln Glu Asn Cys Asp Lys Pro Arg Arg 
    130                 135                 


<210>  85
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  85

Ser Leu Gly Ser Leu Ala Ala Ala Glu Pro Ala Val Ile Ala Glu Cys 
1               5                   10                  15      


Lys Thr Arg Thr Glu Val Phe Gln Ile Ser Arg Asn Leu Ile Asp Arg 
            20                  25                  30          


Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg 
        35                  40                  45              


Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Ala Ser Gln 
    50                  55                  60                  


Val Gln Met Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys 
65                  70                  75                  80  


Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala 
                85                  90                  95      


Cys Lys Cys Glu Thr Ile Val Thr Pro Arg Pro Val Thr Ala Gly Ser 
            100                 105                 110         


Gly Gly Ser Arg Lys Arg Leu Gln Val Gln Leu Ser Ile Arg Thr 
        115                 120                 125         


